subject:(virus de l hepatitis C VHC virus de la immunodefici ncia humana VIH coinfecci VHC VIH model lineal generalitzat GLM dany hep tic fibrosi hep tica ndexs indirectes fibrosi hep tica APRI IF FIB 4 polimorfismes hostes haplogrups mitocondrials LDLr CTLA4 IL28b HFE)

1. Matas Crespí, Marina. Interacció VHC-hoste: Estudi genètic i clínic en pacients coinfectats amb VHC-VIH.

Degree: Departament de Biologia, 2013, Universitat de les Illes Balears

► L’Organització Mundial de la Salut (OMS) estima que fins a un 3% de la població mundial ha estat infectada pel virus de l’hepatitis C i… (more)

Subjects/Keywords: virus de l’hepatitis C, VHC, virus de la immunodeficiència humana, VIH, coinfecció VHC-VIH, model lineal generalitzat, GLM, dany hepàtic, fibrosi hepàtica, índexs indirectes fibrosi hepàtica, APRI, IF, FIB-4, polimorfismes hostes, haplogrups mitocondrials, LDLr, CTLA4, IL28b, HFE; virus de la hepatitis C, VHC, virus de la inmunodeficiencia humana, VIH, coinfección VHC-VIH, modelo lineal generalizado, GLM, daño hepàtico, fibrosis hepàtica, índices indirectos de fibrosis hepática, APRI, IF, FIB-4, polimorfismos huéspedes, haplogrupos mitocondriales, LDLr, CTLA4, IL28b, HFE; hepatitis C virus, HCV, human immunodeficiency virus, HIV, HCV-HIV coinfection, Generalized linear models, GLM, liver damage, liver fibrosis, fibrosis indirect indexes, APRI, IF, FIB-4, host polymorphisms, mtDNA haplogroups, LDLr, CTLA4, IL28b, HFE; Ciències de la salut; 57; 576

…Mentre la prevalença de coinfecció VHC i el virus de la immunodeficiència humana-1 (VIH-1… …19 A. B. 4. VIH COM A MODIFICADOR DE LA INFECCIÓ PEL VHC… …PATOLOGIA DEL VHC A. Història natural de la infecció La transmissió del virus de l’hepatitis C es… …virus de la immunodeficiència humana (HIV) o amb el virus de la hepatitis B (… …5 1. EL VIRUS DE L’HEPATITIS C (VHC)…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Matas Crespí, M. (2013). Interacció VHC-hoste: Estudi genètic i clínic en pacients coinfectats amb VHC-VIH. (Thesis). Universitat de les Illes Balears. Retrieved from http://hdl.handle.net/10803/111335

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Matas Crespí, Marina. “Interacció VHC-hoste: Estudi genètic i clínic en pacients coinfectats amb VHC-VIH.” 2013. Thesis, Universitat de les Illes Balears. Accessed January 15, 2021. http://hdl.handle.net/10803/111335.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Matas Crespí, Marina. “Interacció VHC-hoste: Estudi genètic i clínic en pacients coinfectats amb VHC-VIH.” 2013. Web. 15 Jan 2021.

Vancouver:

Matas Crespí M. Interacció VHC-hoste: Estudi genètic i clínic en pacients coinfectats amb VHC-VIH. [Internet] [Thesis]. Universitat de les Illes Balears; 2013. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10803/111335.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Matas Crespí M. Interacció VHC-hoste: Estudi genètic i clínic en pacients coinfectats amb VHC-VIH. [Thesis]. Universitat de les Illes Balears; 2013. Available from: http://hdl.handle.net/10803/111335

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Ahmed El Sayed, Neveen. Study of RNA synthesis of hepatitis C virus in vitro and in cells of hepatocarcinoma : Etude de la synthèse de l'ARN du virus de l'hépatite C in vitro et dans des cellules d’hépatocarcinomes.

Degree: Docteur es, Sciences, technologie, santé. Microbiologie, 2011, Université de Bordeaux Segalen

URL: http://www.theses.fr/2011BOR21868

►

La polymérase NS5B du virus de l’hépatite C (VHC) porte une activité ARN polymérase ARN-dépendante essentielle pour la réplication de l'ARN génomique viral. Cette réplication… (more)

▼

La polymérase NS5B du virus de l’hépatite C (VHC) porte une activité ARN polymérase ARN-dépendante essentielle pour la réplication de l'ARN génomique viral. Cette réplication implique la synthèse d'un intermédiaire de réplication de polarité négative. In vitro et probablement in vivo, la NS5B initie la synthèse d'ARN par un mécanisme de novo qui nécessite des interactions spécifiques entre la polymérase virale et des éléments des ARN viraux. Dans une première partie nous avons étudié le rôle du GTP et d’un domaine C-terminal nommé linker de la polymérase. Nos résultats démontrent que des concentrations élevées de GTP sont nécessaires pour la transition de l'initiation à l'élongation de la synthèse de l'ARN. Des mutations dans le linker à la position 556 ne modifient pas la concentration de GTP nécessaire pour la transition. Toutefois, l'initiation de la synthèse d'ARN est augmentée par la mutation S556K. Une analyse structurale menée en parallèle suggère une implication directe du linker dans l'initiation de novo de la synthèse de l'ARN. Dans les deuxièmes et troisièmes parties, nous avons étudié le rôle de motifs ARN dans la traduction et la synthèse de l’'ARN du VHC. Nous avons démontré que la tige boucle SL-E1 formée par la région entre les nt 177 et 222 de l'extrémité 3' de l’ARN (-) est importante pour la synthèse d'ARN in vitro par la NS5B recombinante et dans les cellules Huh7 exprimant le complexe de réplication (RC) du VHC. SL-E1 est impliquée dans l’initiation de la synthèse d’ARN, au moins in vitro. Nous avons également étudié le rôle des tiges boucles SLV et SLVI du gène core. Nos données n'ont pas montré de rôle évident de ces séquences ou de leur complément dans la synthèse de l'ARN in vitro par la NS5B recombinante et en culture cellulaire par le RC du VHC. Nous avons confirmé leur effet négatif sur la traduction IRES dépendante par interaction ARN-ARN longue distance entre SL-VI et le 5'UTR et démontré que le miR122 ne peut pas empêcher cet interaction. Par contre, la présence de SL-VI prévient l’inhibition de la traduction induite par l’interaction entre le domaine III de l’IRES et la tige boucle 5BSL3.2 en 3’ du génome. Ces résultats démontrent la complexité des interactions ARN/ARN et ARN/protéines dans la régulation de la réplication virale.

The hepatitis C virus (HCV) NS5B protein displays a RNA-dependent RNA polymerase activity essential for replication of the viral RNA genome. This replication involves the synthesis of a replication intermediate of negative polarity. In vitro and likely in vivo, the NS5B initiates RNA synthesis by a de novo mechanism which requires specific interactions between the polymerase and viral RNA elements. In the first part of results, we described a combined structural and functional analysis of HCV-NS5B to study the role of a C-terminal segment (termed linker) and of GTP in RNA synthesis. Our results demonstrated that high GTP concentrations are necessary for the transition from the initiation to the elongation of RNA synthesis, and that linker mutations at…

Advisors/Committee Members: Astier Gin, Thérèse (thesis director).

Subjects/Keywords: Virus de l'hépatite C; Synthèse de l'ARN; Polymérase du VHC; GTP; Hepatitis C virus; RNA synthesis; Polymerase of HCV; GTP

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ahmed El Sayed, N. (2011). Study of RNA synthesis of hepatitis C virus in vitro and in cells of hepatocarcinoma : Etude de la synthèse de l'ARN du virus de l'hépatite C in vitro et dans des cellules d’hépatocarcinomes. (Doctoral Dissertation). Université de Bordeaux Segalen. Retrieved from http://www.theses.fr/2011BOR21868

Chicago Manual of Style (16^th Edition):

Ahmed El Sayed, Neveen. “Study of RNA synthesis of hepatitis C virus in vitro and in cells of hepatocarcinoma : Etude de la synthèse de l'ARN du virus de l'hépatite C in vitro et dans des cellules d’hépatocarcinomes.” 2011. Doctoral Dissertation, Université de Bordeaux Segalen. Accessed January 15, 2021. http://www.theses.fr/2011BOR21868.

MLA Handbook (7^th Edition):

Ahmed El Sayed, Neveen. “Study of RNA synthesis of hepatitis C virus in vitro and in cells of hepatocarcinoma : Etude de la synthèse de l'ARN du virus de l'hépatite C in vitro et dans des cellules d’hépatocarcinomes.” 2011. Web. 15 Jan 2021.

Vancouver:

Ahmed El Sayed N. Study of RNA synthesis of hepatitis C virus in vitro and in cells of hepatocarcinoma : Etude de la synthèse de l'ARN du virus de l'hépatite C in vitro et dans des cellules d’hépatocarcinomes. [Internet] [Doctoral dissertation]. Université de Bordeaux Segalen; 2011. [cited 2021 Jan 15]. Available from: http://www.theses.fr/2011BOR21868.

Council of Science Editors:

Ahmed El Sayed N. Study of RNA synthesis of hepatitis C virus in vitro and in cells of hepatocarcinoma : Etude de la synthèse de l'ARN du virus de l'hépatite C in vitro et dans des cellules d’hépatocarcinomes. [Doctoral Dissertation]. Université de Bordeaux Segalen; 2011. Available from: http://www.theses.fr/2011BOR21868

Australian National University

3. Saulo, Dina Raus. Infectious Diseases Among Marginalised Populations .

Degree: 2015, Australian National University

URL: http://hdl.handle.net/1885/107141

► From February 2013 to November 2014 I undertook a field placement at the Kirby Institute for Infection and Immunity in Society (the Kirby Institute), as… (more)

▼ From February 2013 to November 2014 I undertook a field placement at the Kirby Institute for Infection and Immunity in Society (the Kirby Institute), as a part of a Master of Philosophy in Applied Epidemiology (MAE). This bound volume is the product of projects undertaken while at the Kirby Institute in the Justice Health Research Program and the Public Health Interventions Research Group. Within are six chapters which demonstrate work undertaken, lessons learnt, knowledge gained and MAE requirements met. Due to my placement predominantly in the justice health research program, three out of four major projects have a focus on blood borne viruses and associated risk factors among offender populations. I evaluated the national prison entrant’s blood borne virus and risk behaviour survey (NPEBBVS), the only multi-jurisdictional prison BBV monitoring mechanism nationally. As a data analysis project I explored hepatitis B core antibody and hepatitis C antibody prevalence and associated risk factors among Indigenous and non-Indigenous prison entrants from the NPEBBVS. Findings from this chapter were presented at a number of conferences and events. As an acute public health problem, I had the opportunity to investigate hepatitis C (HCV) incidence cases in a prison facility. We developed a case series study using mixed methods to collect data on the unusual cluster of HCV cases. I conducted both quantitative and qualitative interviews with participating inmates to gather prisoner’s perspective of HCV incidence, understanding routes of transmission in the prison setting and possible strategies in decreasing exposure and risk. From the start of 2013 I was involved in the ‘vaccine impact in the Indigenous population’ (VIP- I) study with a large group of investigators. The aim of VIP-I was to evaluate the effectiveness of the HPV vaccine among Indigenous women in Australia. My role in the study was as a field coordinator, chapter 5 demonstrates my involvement from the development stage onwards. This chapter is largely methodological, only preliminary results are presented as recruitment is still ongoing. Teaching experience during the MAE included; lessons from the field and a group teaching session with MAE peers. I worked individually on a project management module for the lesson from the field exercise, my fellow MAE cohort completed this module which touched on interdisciplinary collaboration in research. The group teaching experience was created and conducted with two fellow MAE scholars, we built a framework to distinguish real or artificial rate change when interpreting time series data. The projects within this thesis contribute to the Kirby Institutes area of work with marginalised at risk populations. I have been fortunate to be a part of a number of projects that have potential to…

Subjects/Keywords: Aboriginal; Indigenous; Prison; Prisoners; BBV; Blood Borne Viruses; Hep C; HCV; Hepatitis C; Hepatitis B; HBV; Hep B; HPV; Human Papiloma Virus; HPV vaccine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Saulo, D. R. (2015). Infectious Diseases Among Marginalised Populations . (Thesis). Australian National University. Retrieved from http://hdl.handle.net/1885/107141

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Saulo, Dina Raus. “Infectious Diseases Among Marginalised Populations .” 2015. Thesis, Australian National University. Accessed January 15, 2021. http://hdl.handle.net/1885/107141.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Saulo, Dina Raus. “Infectious Diseases Among Marginalised Populations .” 2015. Web. 15 Jan 2021.

Vancouver:

Saulo DR. Infectious Diseases Among Marginalised Populations . [Internet] [Thesis]. Australian National University; 2015. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/1885/107141.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Saulo DR. Infectious Diseases Among Marginalised Populations . [Thesis]. Australian National University; 2015. Available from: http://hdl.handle.net/1885/107141

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

4. Valls Pla, Xavier. Multi-level Parallelization in ROOT: New Patterns, Libraries and Utilities.

Degree: Departament d'Enginyeria i Ciència dels Computadors, 2018, Universitat Jaume I

URL: http://hdl.handle.net/10803/663536

► El Gran Col·lisionador d'Hadrons (LHC) genera dades a un ritme sense precedents, que es preveu que continue augmentant en un futur. Aquesta situació es tradueix… (more)

Subjects/Keywords: Parallelism; ROOT; Software; Vectorization; HEP analysis; C++; Tecnologies de la informació i les comunicacions (TIC); 004

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Valls Pla, X. (2018). Multi-level Parallelization in ROOT: New Patterns, Libraries and Utilities. (Thesis). Universitat Jaume I. Retrieved from http://hdl.handle.net/10803/663536

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Valls Pla, Xavier. “Multi-level Parallelization in ROOT: New Patterns, Libraries and Utilities.” 2018. Thesis, Universitat Jaume I. Accessed January 15, 2021. http://hdl.handle.net/10803/663536.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Valls Pla, Xavier. “Multi-level Parallelization in ROOT: New Patterns, Libraries and Utilities.” 2018. Web. 15 Jan 2021.

Vancouver:

Valls Pla X. Multi-level Parallelization in ROOT: New Patterns, Libraries and Utilities. [Internet] [Thesis]. Universitat Jaume I; 2018. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10803/663536.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Valls Pla X. Multi-level Parallelization in ROOT: New Patterns, Libraries and Utilities. [Thesis]. Universitat Jaume I; 2018. Available from: http://hdl.handle.net/10803/663536

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universitat de Barcelona

5. Larrousse Morellón, Maria. Avances en el diagnóstico de la fibrosis hepática, manejo y tratamiento de la hepatitis crónica por el virus de la hepatitis C en pacientes infectados por el virus de la inmunodeficiencia humana.

Degree: Departament de Medicina, 2009, Universitat de Barcelona

URL: http://hdl.handle.net/10803/2330

► DE LA TESIS: En los países desarrollados, la introducción del tratamiento antirretroviral de gran actividad (TARGA) ha revolucionado la perspectiva del paciente infectado por el… (more)

Subjects/Keywords: Virus de l'Hepatitis C (VHC); Síndrome d'Immunodeficiència Adquirida (SIDA); Tractament antiretroviral de gran activitat (TARGA; Virus de l'Immunodeficiència Humana tipus 1 (VIH); Ciències de la Salut; 578; 616

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Larrousse Morellón, M. (2009). Avances en el diagnóstico de la fibrosis hepática, manejo y tratamiento de la hepatitis crónica por el virus de la hepatitis C en pacientes infectados por el virus de la inmunodeficiencia humana. (Thesis). Universitat de Barcelona. Retrieved from http://hdl.handle.net/10803/2330

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Larrousse Morellón, Maria. “Avances en el diagnóstico de la fibrosis hepática, manejo y tratamiento de la hepatitis crónica por el virus de la hepatitis C en pacientes infectados por el virus de la inmunodeficiencia humana.” 2009. Thesis, Universitat de Barcelona. Accessed January 15, 2021. http://hdl.handle.net/10803/2330.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Larrousse Morellón, Maria. “Avances en el diagnóstico de la fibrosis hepática, manejo y tratamiento de la hepatitis crónica por el virus de la hepatitis C en pacientes infectados por el virus de la inmunodeficiencia humana.” 2009. Web. 15 Jan 2021.

Vancouver:

Larrousse Morellón M. Avances en el diagnóstico de la fibrosis hepática, manejo y tratamiento de la hepatitis crónica por el virus de la hepatitis C en pacientes infectados por el virus de la inmunodeficiencia humana. [Internet] [Thesis]. Universitat de Barcelona; 2009. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10803/2330.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Larrousse Morellón M. Avances en el diagnóstico de la fibrosis hepática, manejo y tratamiento de la hepatitis crónica por el virus de la hepatitis C en pacientes infectados por el virus de la inmunodeficiencia humana. [Thesis]. Universitat de Barcelona; 2009. Available from: http://hdl.handle.net/10803/2330

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universitat Autònoma de Barcelona

6. Bejarano Redondo, Guillermina. Evaluación de la fibrosis hepática en la hepatitis crónica por virus C mediante la aplicación de un índice indirecto no invasivo. Evaluación prospectiva de la utilidad de los índices indirectos no invasivos para la predicción de la evolución a cirrosis hepática.

Degree: Departament de Medicina, 2015, Universitat Autònoma de Barcelona

URL: http://hdl.handle.net/10803/378375

► Hepatitis C is an infection of the liver caused by HCV. Approximately 170 million people are infected worldwide. The prognosis of chronic HCV liver disease… (more)

▼ Hepatitis C is an infection of the liver caused by HCV. Approximately 170 million people are infected worldwide. The prognosis of chronic HCV liver disease depends largely on the progression of liver fibrosis. Several authors have developed noninvasive indices for the diagnosis of significant fibrosis or cirrhosis ignoring performing liver biopsy, but despite the existence of multiple predictive scores or FibroScan®, none of them has managed to replace biopsy as ideal system yet. In recent consensus documents of the American Association for the Study of Liver Diseases and the European Association for the Study of Liver Disease accept non-invasive methods for assessing fibrosis in patients with chronic hepatitis C, leaving the biopsy as a method in case of diagnostic uncertainty. However, the capacity of non-invasive methods to predict progression to cirrhosis has not been established. Our group has developed and validated a predictive noninvasive Sabadell's NIHCED score to discriminate between patients who have already developed cirrhosis, and uses the parameters that are used in everyday clinical practice to assess the monitoring of patients with chronic hepatitis C, making it economically possible in practice. This thesis develops two studies. The first is to determine the ability of discrimination NIHCED index in patients with chronic hepatitis C between the presence or absence of significant fibrosis. The results show that the ability to distinguish between NIHCED significant fibrosis and fibrosis absent or expansion site (cutoff of 6) decreases sensitivity 72%, specificity 76.3%, PPV 81%, NPV of 63.7% and a diagnostic accuracy of 72.5% and an area under the ROC curve was 0.787 (confidence interval 0.73 to 0.83). These results are equivalent to those obtained with other non-invasive methods. On the other hand, we try to validate noninvasive scores APRI, NIHCED and Forns as predictors of progression to cirrhosis. A cohort of patients with HCV infection with a baseline biopsy was recruited to assess the progression to liver cirrhosis based on the values of baseline noninvasive methods follow-up period of 10 years, using non-invasive methods and liver biopsy control if the first didn’t match. 290 patients were recruited. An area under the ROC curve for the prediction of cirrhosis 0.83 for Forns, 0.79 for APRI and 0.76 for NIHCED was obtained. The sensitivity and specificity for predicting cirrhosis, respectively, were 75% and 71% for Forns (cutoff 4.7), 86% and 42% for APRI (cutoff 0.48), and 41% and 82% for NIHCED (cutoff 0). The area under the ROC curve to predict mortality based on baseline noninvasive methods was 0.86 for Forns,0.79 for APRI 0.79 and 0.84 for NIHCED Advisors/Committee Members: [email protected] (authoremail), true (authoremailshow), Calvet Calvo, Xavier (director), Vergara Gómez, Mercedes (director), true (authorsendemail).

Subjects/Keywords: Hepatitis crònica per virus C; Hepatitis crónica por virus C; Chronic hepatitis C; Fibrosi hepàtica; Fibrosis hepática; Liver fibrosis; Mètodes no invasius; Métodos no invasivos; Non-invasive methods; Ciències de la Salut; 616.9

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bejarano Redondo, G. (2015). Evaluación de la fibrosis hepática en la hepatitis crónica por virus C mediante la aplicación de un índice indirecto no invasivo. Evaluación prospectiva de la utilidad de los índices indirectos no invasivos para la predicción de la evolución a cirrosis hepática. (Thesis). Universitat Autònoma de Barcelona. Retrieved from http://hdl.handle.net/10803/378375

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bejarano Redondo, Guillermina. “Evaluación de la fibrosis hepática en la hepatitis crónica por virus C mediante la aplicación de un índice indirecto no invasivo. Evaluación prospectiva de la utilidad de los índices indirectos no invasivos para la predicción de la evolución a cirrosis hepática.” 2015. Thesis, Universitat Autònoma de Barcelona. Accessed January 15, 2021. http://hdl.handle.net/10803/378375.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bejarano Redondo, Guillermina. “Evaluación de la fibrosis hepática en la hepatitis crónica por virus C mediante la aplicación de un índice indirecto no invasivo. Evaluación prospectiva de la utilidad de los índices indirectos no invasivos para la predicción de la evolución a cirrosis hepática.” 2015. Web. 15 Jan 2021.

Vancouver:

Bejarano Redondo G. Evaluación de la fibrosis hepática en la hepatitis crónica por virus C mediante la aplicación de un índice indirecto no invasivo. Evaluación prospectiva de la utilidad de los índices indirectos no invasivos para la predicción de la evolución a cirrosis hepática. [Internet] [Thesis]. Universitat Autònoma de Barcelona; 2015. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10803/378375.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bejarano Redondo G. Evaluación de la fibrosis hepática en la hepatitis crónica por virus C mediante la aplicación de un índice indirecto no invasivo. Evaluación prospectiva de la utilidad de los índices indirectos no invasivos para la predicción de la evolución a cirrosis hepática. [Thesis]. Universitat Autònoma de Barcelona; 2015. Available from: http://hdl.handle.net/10803/378375

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

7. Murillas Angoiti, Javier. Tratamiento e historia natural de la Hepatitis crónica C en pacientes coinfectados por VIH-1.

Degree: Departament de Medicina, 2009, Universitat de Barcelona

URL: http://hdl.handle.net/10803/2331

► En la segunda mitad del siglo XX se produjo probablemente la diseminación inicial del virus de la hepatitis C (VHC) a través de inyecciones parenterales… (more)

Subjects/Keywords: Síndrome d'Immunodeficiència Adquirida (SIDA); Virus de l'Immunodeficiència Humana tipus 1 (VIH); Virus de l'Hepatitis C (VHC); Ciències de la Salut; 578; 616

…virus de la hepatitis C (VHC) a través de inyecciones parenterales poco seguras… …9 2. INTERACCIÓN ENTRE EL VIH Y EL VHC �� ….10 3. TRATAMIENTO DE LA… …HEPATITIS CRÓNICA C 1. 1. ¿ES PREFERIBLE LA UTILIZACIÓN DE PEGIFN ALFA 2-A FRENTE A PEGIFN ALFA 2… …52 1.3. ¿AFECTA NEGATIVAMENTE A LA EFICACIA DEL TRATAMIENTO DE LA HEPATITIS CRÓNICA C LA… …línea de investigación: el cuidado de los enfermos de hepatitis crónica C e infección VIH-1…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Murillas Angoiti, J. (2009). Tratamiento e historia natural de la Hepatitis crónica C en pacientes coinfectados por VIH-1. (Thesis). Universitat de Barcelona. Retrieved from http://hdl.handle.net/10803/2331

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Murillas Angoiti, Javier. “Tratamiento e historia natural de la Hepatitis crónica C en pacientes coinfectados por VIH-1.” 2009. Thesis, Universitat de Barcelona. Accessed January 15, 2021. http://hdl.handle.net/10803/2331.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Murillas Angoiti, Javier. “Tratamiento e historia natural de la Hepatitis crónica C en pacientes coinfectados por VIH-1.” 2009. Web. 15 Jan 2021.

Vancouver:

Murillas Angoiti J. Tratamiento e historia natural de la Hepatitis crónica C en pacientes coinfectados por VIH-1. [Internet] [Thesis]. Universitat de Barcelona; 2009. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10803/2331.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Murillas Angoiti J. Tratamiento e historia natural de la Hepatitis crónica C en pacientes coinfectados por VIH-1. [Thesis]. Universitat de Barcelona; 2009. Available from: http://hdl.handle.net/10803/2331

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Indian Institute of Science

8. Ray, Upasana. Unravelling The Regulators Of Translation And Replication Of Hepatitis C Virus.

Degree: PhD, Faculty of Science, 2013, Indian Institute of Science

URL: http://etd.iisc.ac.in/handle/2005/2032

► Unravelling the regulators of translation and replication of Hepatitis C virus Hepatitis C virus (HCV) is a positive sense, single stranded RNA virus belonging to… (more)

▼ Unravelling the regulators of translation and replication of Hepatitis C virus Hepatitis C virus (HCV) is a positive sense, single stranded RNA virus belonging to the genus Hepacivirus and the family Flaviviridae. It infects human liver cells predominantly. Although, the treatment with α interferon and ribavirin can control HCV in some cases, they fail to achieve sustained virological response in others, thus emphasizing the need of novel therapeutic targets. The viral genome is 9.6 kb long consisting of a 5’ untranslated region (5’UTR), a long open reading frame (ORF) that encodes the viral proteins and the 3’ untranslated region (3’UTR). The 5’UTR contains a cis acting element, the internal ribosome entry site (IRES) that mediates the internal initiation of translation. The HCV 5’UTR is highly structured and consists of four major stem-loops (SL) and a pseudoknot structure. HCV proteins are synthesized by the IRES mediated translation of the viral RNA, which is the initial obligatory step after infection. The viral proteins are synthesized in the form of a long continuous chain of proteins, the polyprotein, which is then processed by the host cell and the viral proteases. Once viral proteins are synthesized sufficiently, the viral RNA is replicated. However the mechanism of switch from translation to viral RNA replication is not well understood. Several host proteins as well as the viral proteins help in the completion of various steps in the HCV life cycle. In this thesis, the role of two such factors in HCV RNA translation and replication has been characterized and exploited to develop anti-HCV peptides. The HCV proteins are categorized into two major classes based on the functions broadly: the non structural and the structural proteins. HCV NS3 protein (one of the viral non structural proteins) plays a central role in viral polyprotein processing and RNA replication. In the first part of the thesis, it has been demonstrated that the NS3 protease (NS3pro) domain alone can specifically bind to HCV-IRES RNA, predominantly in the SLIV region. The cleavage activity of the NS3 protease domain is reduced upon HCV-RNA binding owing to the participation of the catalytic triad residue (Ser 139) in this RNA protein interaction. More importantly, NS3pro binding to the SLIV region hinders the interaction of La protein, a cellular IRES-trans acting factor required for HCV IRES-mediated translation, thus resulting in the inhibition of HCV-IRES activity. Moreover excess La protein could rescue the inhibition caused by the NS3 protease. Additionally it was observed that the NS3 protease and human La protein could out-compete each other for binding to the HCV SL IV region indicating that these two proteins share the binding region near the initiator AUG which was further confirmed using RNase T1 foot printing assay. Although an over expression of NS3pro as well as the full length NS3 protein decreased the level of HCV IRES mediated translation in the cells, replication of HCV RNA was enhanced significantly. These observations… Advisors/Committee Members: Das, Saumitra (advisor).

Subjects/Keywords: Hepatitis C Virus (HCV); Hepatitis C Virus - Replication; HCV-NS3 Protein; Non-structural Protein 3; Human La Protein; HCV IRES; NS3 Protease; Hep C Viral Switch; Hepatitis C Viral RNA; NS3 Protein; Virology

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APA (6^th Edition):

Ray, U. (2013). Unravelling The Regulators Of Translation And Replication Of Hepatitis C Virus. (Doctoral Dissertation). Indian Institute of Science. Retrieved from http://etd.iisc.ac.in/handle/2005/2032

Chicago Manual of Style (16^th Edition):

Ray, Upasana. “Unravelling The Regulators Of Translation And Replication Of Hepatitis C Virus.” 2013. Doctoral Dissertation, Indian Institute of Science. Accessed January 15, 2021. http://etd.iisc.ac.in/handle/2005/2032.

MLA Handbook (7^th Edition):

Ray, Upasana. “Unravelling The Regulators Of Translation And Replication Of Hepatitis C Virus.” 2013. Web. 15 Jan 2021.

Vancouver:

Ray U. Unravelling The Regulators Of Translation And Replication Of Hepatitis C Virus. [Internet] [Doctoral dissertation]. Indian Institute of Science; 2013. [cited 2021 Jan 15]. Available from: http://etd.iisc.ac.in/handle/2005/2032.

Council of Science Editors:

Ray U. Unravelling The Regulators Of Translation And Replication Of Hepatitis C Virus. [Doctoral Dissertation]. Indian Institute of Science; 2013. Available from: http://etd.iisc.ac.in/handle/2005/2032

9. Shen, Hong. Hepatitis C infection models : Modèles d'infection de l'hépatite C.

Degree: Docteur es, Virologie, 2012, Université Paris Descartes – Paris V

URL: http://www.theses.fr/2012PA05T016

► L'hépatite C (VHC) est l'une des causes principales de maladies du foie dans le monde, qui représentent un risque élevé d'évoluer vers la cirrhose et… (more)

Subjects/Keywords: Virus de l’Hépatite C (VHC); Modèle animal; Tupaia; CD81; Culture de tissus; Propagation du virus; Physiologie hépatocellulaire; Essai des drogues antivirales; Hepatitis C virus (HCV); Animal model; Tupaia; CD81; Tissue culture; Virus spreading; Hepatocellular physiology; Antiviral drugs assay

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shen, H. (2012). Hepatitis C infection models : Modèles d'infection de l'hépatite C. (Doctoral Dissertation). Université Paris Descartes – Paris V. Retrieved from http://www.theses.fr/2012PA05T016

Chicago Manual of Style (16^th Edition):

Shen, Hong. “Hepatitis C infection models : Modèles d'infection de l'hépatite C.” 2012. Doctoral Dissertation, Université Paris Descartes – Paris V. Accessed January 15, 2021. http://www.theses.fr/2012PA05T016.

MLA Handbook (7^th Edition):

Shen, Hong. “Hepatitis C infection models : Modèles d'infection de l'hépatite C.” 2012. Web. 15 Jan 2021.

Vancouver:

Shen H. Hepatitis C infection models : Modèles d'infection de l'hépatite C. [Internet] [Doctoral dissertation]. Université Paris Descartes – Paris V; 2012. [cited 2021 Jan 15]. Available from: http://www.theses.fr/2012PA05T016.

Council of Science Editors:

Shen H. Hepatitis C infection models : Modèles d'infection de l'hépatite C. [Doctoral Dissertation]. Université Paris Descartes – Paris V; 2012. Available from: http://www.theses.fr/2012PA05T016

Universitat Autònoma de Barcelona

10. Cañete Hidalgo, Nuria. Evolución a largo plazo de pacientes con hepatitis C y fibrosis leve-moderada después del tratamiento antivírico. Importancia de su evaluación mediante biopsia hepática o elastografía.

Degree: Departament de Medicina, 2017, Universitat Autònoma de Barcelona

URL: http://hdl.handle.net/10803/457518

► Hepatitis C infection affects between 130-150 million people, being one of most prevalent viral infections and leading cause of liver disease in developed countries. Majority… (more)

▼ Hepatitis C infection affects between 130-150 million people, being one of most prevalent viral infections and leading cause of liver disease in developed countries. Majority of detected cases are in chronic phase that causes a variable degree of inflammation and fibrosis, which can evolve to hepatic cirrhosis and / or hepatocellular carcinoma, and may be modified by antiviral treatment. Objectives of this Thesis are to analyze progression of fibrosis in patients with mild-moderate fibrosis by previous LB and subsequent LB or ET, in addition to assessing the influence of antiviral treatment in this progression as well as in the evolution of liver disease. A total of 291 patients who had been treated were included. Group 1 included 107 patients with paired LB and in group 2, 184 patients with TE. Progression of fibrosis was defined as increase in the stage of fibrosis, as well as the progression to liver disease and its possibles complications. Fibrosis in initial LB was grade 0 in 87 patients (29.9%), grade 1 in 134 patients (46%) and grade 2 in 70 patients (24.1%), with no difference between two study groups. Significant differences were observed between 3 stages of fibrosis in the value of platelets, prothrombin, cholesterol, GOT, GPT and GGT, which may translate into a higher degree of hepatic involvement. All patients started antiviral treatment after LB. At the end of follow-up, fibrosis progressed in 79 patients (27.1%), 120 patients (41.2%) remained the same and in 92 patients (31.6%) there was improvement. Rate of progression quantified by variation of METAVIR score per year was 0.091 + -0.11 in NR and -0.083 + -0.08 in RVS (P <0.0001). Patients with F0 presented lower fibrosis progression than F1 and F2 (P <0.0001). Overall probability of advanced fibrosis (F3 / 4) was 1.9% at 10 years and 27.6% at 20 years. In patients with and without SVR, was 0 and 10.2% (SVR) and 7.2 and 55.7% (NR), respectively (P <0.0001). Probability of cirrhosis was 1.5% and 22.6% at 10 and 20 years. There were also marked differences between patients who achieved SVR (0 and 5.8% at 10 and 20 years) and who not (9,8 y 50,5% in same periods) (P<0,0001). Probability of CHC during the global follow up was 1 and 9.8% at 10 and 20 years. Survival probability was 1 and 13.8% at 10 and 20 years, respectively. This Thesis has shown that patients without fibrosis in the initial BH have a smaller progression of fibrosis, and is almost null in those that reach RVS. TE allows an evaluation of the progression of fibrosis with an efficacy similar to LB. It has been observed that the retreatment of NR patients avoids the progression in those who reach SVR, whereas the probability of cirrhosis in patients NR to treatment and retreatment is 50% at 20 years. Current Thesis shows value of antiviral treatment and importance to achieve SVR. Advisors/Committee Members: [email protected] (authoremail), true (authoremailshow), Solà Lamoglia, Ricard (director), Cirera Lorenzo, Isabel (director), true (authorsendemail).

Subjects/Keywords: Hepatitis C; Fibrosi; Fibrosis; Evolució; Evolución; Evolution; Ciències de la Salut; 616.3

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cañete Hidalgo, N. (2017). Evolución a largo plazo de pacientes con hepatitis C y fibrosis leve-moderada después del tratamiento antivírico. Importancia de su evaluación mediante biopsia hepática o elastografía. (Thesis). Universitat Autònoma de Barcelona. Retrieved from http://hdl.handle.net/10803/457518

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cañete Hidalgo, Nuria. “Evolución a largo plazo de pacientes con hepatitis C y fibrosis leve-moderada después del tratamiento antivírico. Importancia de su evaluación mediante biopsia hepática o elastografía.” 2017. Thesis, Universitat Autònoma de Barcelona. Accessed January 15, 2021. http://hdl.handle.net/10803/457518.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cañete Hidalgo, Nuria. “Evolución a largo plazo de pacientes con hepatitis C y fibrosis leve-moderada después del tratamiento antivírico. Importancia de su evaluación mediante biopsia hepática o elastografía.” 2017. Web. 15 Jan 2021.

Vancouver:

Cañete Hidalgo N. Evolución a largo plazo de pacientes con hepatitis C y fibrosis leve-moderada después del tratamiento antivírico. Importancia de su evaluación mediante biopsia hepática o elastografía. [Internet] [Thesis]. Universitat Autònoma de Barcelona; 2017. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10803/457518.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cañete Hidalgo N. Evolución a largo plazo de pacientes con hepatitis C y fibrosis leve-moderada después del tratamiento antivírico. Importancia de su evaluación mediante biopsia hepática o elastografía. [Thesis]. Universitat Autònoma de Barcelona; 2017. Available from: http://hdl.handle.net/10803/457518

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

11. Tenesa Bordas, Montserrat. Asociación entre el acúmulo de grasa intraabdominal medido por tomografía computarizada y la gravedad de la fibrosis hepática en pacientes infectados por el virus de la inmunodeficiencia humana y el virus de la hepatitis C.

Degree: Departament de Medicina, 2017, Universitat Autònoma de Barcelona

URL: http://hdl.handle.net/10803/458689

► Since the emergence of highly active antiretroviral therapy (HAART) against HIV, there has been a substantial decline in mortality related to complications of HIV infection… (more)

▼ Since the emergence of highly active antiretroviral therapy (HAART) against HIV, there has been a substantial decline in mortality related to complications of HIV infection and acquired immunodeficiency syndrome (AIDS), however, little impact on reducing deaths related to liver disease. Currently, liver disease in HIV patients is due to a combination of causes such as coinfection with hepatitis C virus, HAART-related hepatotoxicity, microbial translocation and metabolic disorders, such as insulin resistance (IR) and metabolic syndrome (MS). In HIV/HCV co-infected patients, the association of IR with liver fibrosis is especially relevant, since both HCV and HIV infection per se, as well as antiretroviral therapy and persistent chronic inflammation, cause dyslipidemia and IR, as well as intra-abdominal fat accumulation (IFA) and in the hepatocytes, that will evolve to hepatic steatosis and fibrosis and subsequent progression to cirrhosis and hepatocellular carcinoma. The hypothesis of this thesis is that quantification of IFA by abdominal CT is a radiological marker of the severity of hepatic fibrosis in patients with HIV/HCV coinfection. The following objectives are proposed: a) Primary objective: To demonstrate an independent association between CT-measured IFA and the severity of hepatic fibrosis in patients with HIV/HCV coinfection. b) Secondary objectives: 1. To determine the diagnostic accuracy of the radiological variables studied: IFA and quantification of hepatic steatosis in segments III and VI, in order to predict the severity of liver fibrosis. 2. To obtain the optimal cut-off point of the IFA value in detecting the severity of liver fibrosis. 3. To demonstrate the reproducibility of the IFA measurement by CT. 120 consecutive HIV infected and HCV coinfected patients with active viral replication were selected and assessed at the HIV Clinical Unit of the Germans Trias i Pujol University Hospital in Badalona. Anthropometric variables were collected, a blood test was performed, the stage of liver fibrosis was determined by transient elastography and patients were referred to the Radiology Service where they performed the same day an abdominal CT to determine IFA and hepatic steatosis. Quantification of intra-abdominal and subcutaneous fat was carried out with the help of a specific post-processing program. Hepatic steatosis was assessed by obtaining the attenuation coefficient of the liver and spleen. After a first phase of reading and validation of the database, different statistical analyzes were carried out. As for the results, we could confirm that the only independent factor associated with stage F2 fibrosis was IFA. Albumin and body mass index (BMI) were associated with F3. The independent predictors of hepatic cirrhosis were albumin concentration and IFA. Regarding the diagnostic accuracy of IFA and hepatic steatosis, IFA may be considered useful in the prediction of liver fibrosis, in patients with fibrosis. In the diagnosis of cirrhosis, an optimum cutoff point (cm2) for IFA was obtained.… Advisors/Committee Members: [email protected] (authoremail), true (authoremailshow), Pérez Andrés, Ricard (director), Tural i Llacher, C. (director), Tor Aguilera, J. (tutor), true (authorsendemail).

Subjects/Keywords: Fibrosi hepàtica; Fibrosis hepática; Hepatic fibrosis; Coinfecció VIH/VHC; Coinfección VIH/VHC; HIV/HCV coinfection; Acumulació de greix intraabdominal; Acúmulo de grasa intraabdominal; Intraabdominal fat deposition; Ciències de la Salut; 61

…18 LA COINFECCION POR EL VIH Y POR EL VIRUS DE LA HEPATITIS C (VHC)… …virus de la hepatitis C (VHC) o B (VHB), el hígado graso no alcohólico, la… …1 1.1. LA INFECCIÓN POR EL VIRUS DE LA INMUNODEFICIENCIA HUMANA (VIH)… …19 1.2.1. El Virus de la Hepatitis C… …en pacientes infectados por el Virus de la Inmunodeficiencia Humana y el Virus de la…

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APA (6^th Edition):

Tenesa Bordas, M. (2017). Asociación entre el acúmulo de grasa intraabdominal medido por tomografía computarizada y la gravedad de la fibrosis hepática en pacientes infectados por el virus de la inmunodeficiencia humana y el virus de la hepatitis C. (Thesis). Universitat Autònoma de Barcelona. Retrieved from http://hdl.handle.net/10803/458689

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tenesa Bordas, Montserrat. “Asociación entre el acúmulo de grasa intraabdominal medido por tomografía computarizada y la gravedad de la fibrosis hepática en pacientes infectados por el virus de la inmunodeficiencia humana y el virus de la hepatitis C.” 2017. Thesis, Universitat Autònoma de Barcelona. Accessed January 15, 2021. http://hdl.handle.net/10803/458689.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tenesa Bordas, Montserrat. “Asociación entre el acúmulo de grasa intraabdominal medido por tomografía computarizada y la gravedad de la fibrosis hepática en pacientes infectados por el virus de la inmunodeficiencia humana y el virus de la hepatitis C.” 2017. Web. 15 Jan 2021.

Vancouver:

Tenesa Bordas M. Asociación entre el acúmulo de grasa intraabdominal medido por tomografía computarizada y la gravedad de la fibrosis hepática en pacientes infectados por el virus de la inmunodeficiencia humana y el virus de la hepatitis C. [Internet] [Thesis]. Universitat Autònoma de Barcelona; 2017. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10803/458689.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tenesa Bordas M. Asociación entre el acúmulo de grasa intraabdominal medido por tomografía computarizada y la gravedad de la fibrosis hepática en pacientes infectados por el virus de la inmunodeficiencia humana y el virus de la hepatitis C. [Thesis]. Universitat Autònoma de Barcelona; 2017. Available from: http://hdl.handle.net/10803/458689

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidad Autónoma de Madrid

12. Navarro San Francisco, Carolina. Evolución de las características clínicas y epidemiológicas de la coinfección por el virus de la inmunodeficiencia humana y el virus de la hepatitis C en la población española 2010 .

Degree: 2013, Universidad Autónoma de Madrid

URL: http://hdl.handle.net/10486/13597

Subjects/Keywords: VIH (Virus) - Tesis doctorales; Virus de la hepatitis C - Tesis doctorales

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APA (6^th Edition):

Navarro San Francisco, C. (2013). Evolución de las características clínicas y epidemiológicas de la coinfección por el virus de la inmunodeficiencia humana y el virus de la hepatitis C en la población española 2010 . (Doctoral Dissertation). Universidad Autónoma de Madrid. Retrieved from http://hdl.handle.net/10486/13597

Chicago Manual of Style (16^th Edition):

Navarro San Francisco, Carolina. “Evolución de las características clínicas y epidemiológicas de la coinfección por el virus de la inmunodeficiencia humana y el virus de la hepatitis C en la población española 2010 .” 2013. Doctoral Dissertation, Universidad Autónoma de Madrid. Accessed January 15, 2021. http://hdl.handle.net/10486/13597.

MLA Handbook (7^th Edition):

Navarro San Francisco, Carolina. “Evolución de las características clínicas y epidemiológicas de la coinfección por el virus de la inmunodeficiencia humana y el virus de la hepatitis C en la población española 2010 .” 2013. Web. 15 Jan 2021.

Vancouver:

Navarro San Francisco C. Evolución de las características clínicas y epidemiológicas de la coinfección por el virus de la inmunodeficiencia humana y el virus de la hepatitis C en la población española 2010 . [Internet] [Doctoral dissertation]. Universidad Autónoma de Madrid; 2013. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10486/13597.

Council of Science Editors:

Navarro San Francisco C. Evolución de las características clínicas y epidemiológicas de la coinfección por el virus de la inmunodeficiencia humana y el virus de la hepatitis C en la población española 2010 . [Doctoral Dissertation]. Universidad Autónoma de Madrid; 2013. Available from: http://hdl.handle.net/10486/13597

Université de Sherbrooke

13. Picard-Jean, Frédéric. Caractérisation de nouveaux mécanismes d'action chez un antiviral et un immunosuppresseur pléiotropiques: Characterization of novel mechanisms of action from a pleiotropic antiviral and an immunosupressive drug.

Degree: 2013, Université de Sherbrooke

URL: http://hdl.handle.net/11143/16251

► Mes travaux de thèse se sont principalement concentrés sur l'étude de nouveaux mécanismes d'action chez des drogues reconnues et sécuritaires. L'étude de cette pléiotropie mécanistique… (more)

Subjects/Keywords: Virus de l'hépatite C (VHC); Lactoférrine (LF); Antivirale; NS3; Virus du Nil occidental (VNO); ARN; Structure coiffe; Enzyme humaine de synthèse de la structure coiffe (HCE); Mizoribine monophosphate (MZP); Hepatitis C virus (HCV); Lactoferrin (LF); Antiviral; NS3; West Nile virus (WNV); RNA; Cap; Human caping enzyme (HCE); Mizoribine monophosphate (MZP)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Picard-Jean, F. (2013). Caractérisation de nouveaux mécanismes d'action chez un antiviral et un immunosuppresseur pléiotropiques: Characterization of novel mechanisms of action from a pleiotropic antiviral and an immunosupressive drug. (Doctoral Dissertation). Université de Sherbrooke. Retrieved from http://hdl.handle.net/11143/16251

Chicago Manual of Style (16^th Edition):

Picard-Jean, Frédéric. “Caractérisation de nouveaux mécanismes d'action chez un antiviral et un immunosuppresseur pléiotropiques: Characterization of novel mechanisms of action from a pleiotropic antiviral and an immunosupressive drug.” 2013. Doctoral Dissertation, Université de Sherbrooke. Accessed January 15, 2021. http://hdl.handle.net/11143/16251.

MLA Handbook (7^th Edition):

Picard-Jean, Frédéric. “Caractérisation de nouveaux mécanismes d'action chez un antiviral et un immunosuppresseur pléiotropiques: Characterization of novel mechanisms of action from a pleiotropic antiviral and an immunosupressive drug.” 2013. Web. 15 Jan 2021.

Vancouver:

Picard-Jean F. Caractérisation de nouveaux mécanismes d'action chez un antiviral et un immunosuppresseur pléiotropiques: Characterization of novel mechanisms of action from a pleiotropic antiviral and an immunosupressive drug. [Internet] [Doctoral dissertation]. Université de Sherbrooke; 2013. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/11143/16251.

Council of Science Editors:

Picard-Jean F. Caractérisation de nouveaux mécanismes d'action chez un antiviral et un immunosuppresseur pléiotropiques: Characterization of novel mechanisms of action from a pleiotropic antiviral and an immunosupressive drug. [Doctoral Dissertation]. Université de Sherbrooke; 2013. Available from: http://hdl.handle.net/11143/16251

Universitat de Barcelona

14. Sánchez Martín, Ma. Jesús. Estudios biofísicos de péptidos sintéticos de la proteína de envoltura E1 del GBV-C/HGV y su relación con el VIH.

Degree: Departament de Físicoquímica, 2011, Universitat de Barcelona

URL: http://hdl.handle.net/10803/32123

► "BIOPHYSICAL STUDIES OF SYNTHETIC PEPTIDES OF THE ENVELOPE PROTEIN E1 OF GBV-C/HGV AND ITS RELATIONSHIP WITH HIV" The virus C (GBV-C) or hepatitis G virus… (more)

▼ "BIOPHYSICAL STUDIES OF SYNTHETIC PEPTIDES OF THE ENVELOPE PROTEIN E1 OF GBV-C/HGV AND ITS RELATIONSHIP WITH HIV" The virus C (GBV-C) or hepatitis G virus (HGV) is related to hepatitis C virus (HCV) because it has similar genome organization and sequence homology; however, it does not seem to cause hepatitis or any other pathology. In recent years, there have been several studies in which the GBV-C/HGV and human immunodeficiency virus (HIV) co-infection is associated with less progression of the disease caused by HIV as well as improved survival of patients after AIDS has developed. Based on a model of co-infection, there are several theories of how the hepatitis G virus can affect HIV disease: it could induce chemokines, negatively regulate the HIV co-receptors and cause other undefined effects in the host cell. But the mechanism responsible for the beneficial effect that GBV-C/HGV has over the course of infection by HIV is not yet defined. Taking into account the possible use of synthetic peptides, the aim of the present thesis is to carry out the selection of peptides from the envelope protein E1 of GBV-C/HGV with potential ability to inhibit the HIV-1fusion peptide. The aim is to better understand the effect of the presence of antibodies anti-GBV-C/HGV in the progression of AIDS and to study the interaction between these two viruses. The solid phase synthesis of 58 peptides corresponding to the envelope protein E1 of GBV-C/HGV was made and 5 peptides capable of inhibiting the ability of the fusion peptide (FP) of HIV-1 to form pores in membranes were selected by means of the leakage of vesicular contents assay. Detailed studies of the E1 peptides and their ability to inhibit the fusion process induced by the fusion peptide of HIV-1 were done. Monolayers and liposomes were used as model membranes. The different tests show an interaction of the E1 peptides with the HIV-1fusion peptide, resulting in an inhibition of the activity that the fusion peptide has on lipid membranes. This suggests that these peptides could be good candidates for future antiviral therapies. Advisors/Committee Members: [email protected] (authoremail), false (authoremailshow), Alsina Esteller, Ma. Asunción (director), Haro Villar, Isabel (codirector), true (authorsendemail).

Subjects/Keywords: VIH (Virus); HIV (Viruses); Hepatitis C; Liposomes; Liposomas; Monocapa Langmuir-Blodgett; Langmuir-Blodgett monolayer; Pèptids; Péptidos; Peptides; GBV-C; Sida; AIDS (Disease); SIDA; Ciències de la Salut; 615

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APA (6^th Edition):

Sánchez Martín, M. J. (2011). Estudios biofísicos de péptidos sintéticos de la proteína de envoltura E1 del GBV-C/HGV y su relación con el VIH. (Thesis). Universitat de Barcelona. Retrieved from http://hdl.handle.net/10803/32123

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sánchez Martín, Ma Jesús. “Estudios biofísicos de péptidos sintéticos de la proteína de envoltura E1 del GBV-C/HGV y su relación con el VIH.” 2011. Thesis, Universitat de Barcelona. Accessed January 15, 2021. http://hdl.handle.net/10803/32123.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sánchez Martín, Ma Jesús. “Estudios biofísicos de péptidos sintéticos de la proteína de envoltura E1 del GBV-C/HGV y su relación con el VIH.” 2011. Web. 15 Jan 2021.

Vancouver:

Sánchez Martín MJ. Estudios biofísicos de péptidos sintéticos de la proteína de envoltura E1 del GBV-C/HGV y su relación con el VIH. [Internet] [Thesis]. Universitat de Barcelona; 2011. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10803/32123.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sánchez Martín MJ. Estudios biofísicos de péptidos sintéticos de la proteína de envoltura E1 del GBV-C/HGV y su relación con el VIH. [Thesis]. Universitat de Barcelona; 2011. Available from: http://hdl.handle.net/10803/32123

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universitat Autònoma de Barcelona

15. Crespo Casal, Manuel. Tratamiento de la hepatitis crónica C en pacientes coinfectados por VIH.

Degree: Departament de Medicina, 2007, Universitat Autònoma de Barcelona

URL: http://hdl.handle.net/10803/4513

► En esta tesis, se recogen los resultados de un estudio aleatorizado y comparativo llevado a cabo en nuestro centro, en el que se demuestra que… (more)

Subjects/Keywords: Tratamiento; VHC; VIH; Ciències de la Salut; 61

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APA (6^th Edition):

Crespo Casal, M. (2007). Tratamiento de la hepatitis crónica C en pacientes coinfectados por VIH. (Thesis). Universitat Autònoma de Barcelona. Retrieved from http://hdl.handle.net/10803/4513

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Crespo Casal, Manuel. “Tratamiento de la hepatitis crónica C en pacientes coinfectados por VIH.” 2007. Thesis, Universitat Autònoma de Barcelona. Accessed January 15, 2021. http://hdl.handle.net/10803/4513.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Crespo Casal, Manuel. “Tratamiento de la hepatitis crónica C en pacientes coinfectados por VIH.” 2007. Web. 15 Jan 2021.

Vancouver:

Crespo Casal M. Tratamiento de la hepatitis crónica C en pacientes coinfectados por VIH. [Internet] [Thesis]. Universitat Autònoma de Barcelona; 2007. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10803/4513.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Crespo Casal M. Tratamiento de la hepatitis crónica C en pacientes coinfectados por VIH. [Thesis]. Universitat Autònoma de Barcelona; 2007. Available from: http://hdl.handle.net/10803/4513

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

16. Loko, Marc-Arthur. Epidémiologie clinique de la prise en charge des patients co-infectés par le VIH et le virus de l’hépatite C à partir des cohortes ANRS CO 03 Aquitaine et ANRS CO 13 HEPAVIH : Environnement logiciel pour l’assistance à l’autonomie à domicile : gestion de la dynamique et de l’incertitude pour la fourniture sémantique en temps réel de services d’assistance.

Degree: Docteur es, Sciences, technologie, santé. Epidémiologie et santé publique, 2009, Université de Bordeaux Segalen

URL: http://www.theses.fr/2009BOR21693

►

L’infection par le virus de l’hépatite C est fréquente chez les patients infectés par le VIH. Chez les patients co-infectés VIH-VHC, les lésions hépatiques sont… (more)

Subjects/Keywords: Co-infection VIH-VHC; Stéatose hépatique; Scores non invasifs de fibrose hépatique

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Loko, M. (2009). Epidémiologie clinique de la prise en charge des patients co-infectés par le VIH et le virus de l’hépatite C à partir des cohortes ANRS CO 03 Aquitaine et ANRS CO 13 HEPAVIH : Environnement logiciel pour l’assistance à l’autonomie à domicile : gestion de la dynamique et de l’incertitude pour la fourniture sémantique en temps réel de services d’assistance. (Doctoral Dissertation). Université de Bordeaux Segalen. Retrieved from http://www.theses.fr/2009BOR21693

Chicago Manual of Style (16^th Edition):

Loko, Marc-Arthur. “Epidémiologie clinique de la prise en charge des patients co-infectés par le VIH et le virus de l’hépatite C à partir des cohortes ANRS CO 03 Aquitaine et ANRS CO 13 HEPAVIH : Environnement logiciel pour l’assistance à l’autonomie à domicile : gestion de la dynamique et de l’incertitude pour la fourniture sémantique en temps réel de services d’assistance.” 2009. Doctoral Dissertation, Université de Bordeaux Segalen. Accessed January 15, 2021. http://www.theses.fr/2009BOR21693.

MLA Handbook (7^th Edition):

Loko, Marc-Arthur. “Epidémiologie clinique de la prise en charge des patients co-infectés par le VIH et le virus de l’hépatite C à partir des cohortes ANRS CO 03 Aquitaine et ANRS CO 13 HEPAVIH : Environnement logiciel pour l’assistance à l’autonomie à domicile : gestion de la dynamique et de l’incertitude pour la fourniture sémantique en temps réel de services d’assistance.” 2009. Web. 15 Jan 2021.

Vancouver:

Loko M. Epidémiologie clinique de la prise en charge des patients co-infectés par le VIH et le virus de l’hépatite C à partir des cohortes ANRS CO 03 Aquitaine et ANRS CO 13 HEPAVIH : Environnement logiciel pour l’assistance à l’autonomie à domicile : gestion de la dynamique et de l’incertitude pour la fourniture sémantique en temps réel de services d’assistance. [Internet] [Doctoral dissertation]. Université de Bordeaux Segalen; 2009. [cited 2021 Jan 15]. Available from: http://www.theses.fr/2009BOR21693.

Council of Science Editors:

Loko M. Epidémiologie clinique de la prise en charge des patients co-infectés par le VIH et le virus de l’hépatite C à partir des cohortes ANRS CO 03 Aquitaine et ANRS CO 13 HEPAVIH : Environnement logiciel pour l’assistance à l’autonomie à domicile : gestion de la dynamique et de l’incertitude pour la fourniture sémantique en temps réel de services d’assistance. [Doctoral Dissertation]. Université de Bordeaux Segalen; 2009. Available from: http://www.theses.fr/2009BOR21693

Universitat de Barcelona

17. Galatola, Ramona. Péptidos derivados del GB virus C como potenciales inhibidores del virus de la inmunodeficiencia humana tipo 1.

Degree: Departament de Físicoquímica, 2014, Universitat de Barcelona

URL: http://hdl.handle.net/10803/130895

► Interest in the use of synthetic peptides as inhibitors of HIV-1 fusión and entry is growing significantly, given that they are applicable in combined therapies… (more)

▼ Interest in the use of synthetic peptides as inhibitors of HIV-1 fusión and entry is growing significantly, given that they are applicable in combined therapies or when resistance to other antiretroviral drugs is seen and that they act before the virus enters the cell. Recently it has been shown that the coinfection with GBV-C virus and HIV-1 has been associated with slower progression of the illness. Several studies have been published to propose different models of interaction between GBV-C and HIV-1. One of the proposed mechanisms by which GBV-C modulates HIV-1 infection involves inhibiting HIV-1 replication in vitro by GBV-C proteins. In our hands, certain peptide sequences of the E1 envelope protein of the GBV-C virus, as E1P8, inhibit HIV-1 entry, and appear to interact with HIV-1 fusion peptide (FP-HIV-1). Based on these findings, the aim of present thesis is to carry out the design and synthesis of peptides, derivatives of the P8 region of the envelope protein E1 GBV-C, as HIV-1 inhibitors. In order to perform a systematic trial on the structure-activity relationship of these sequences, E1P8 peptide analogues were analyzed in which each of the amino acid residues was replaced by L-Ala. The influence of the total net load of the peptides on the activity through the replacement of residues loaded with neutral amino acids was also studied. Then, the design and synthesis of new strategies of peptide presentation as lipopeptides and cyclic peptide also was performed. The study of interaction between peptide derivatives E1P8 GBV-C and FP-HIV-1 is carried out through biophysical assays with membrane models, cellular assays and finally testing with HIV-1 infection. The results indicate that the primary structure and the net charge of E1P8 influence the activity of the peptide. Lipopeptides interact with FP-HIV-1 and inhibit HIV-1 infectivity better than the native sequence. Although the cyclic E1P8 presents higher inhibitory activity of HIV-1, suggesting that this peptide could be best candidate for use in future antiviral therapies. Advisors/Committee Members: [email protected] (authoremail), false (authoremailshow), Haro Villar, Isabel (director), Gómara Elena, María José (director), García López, María Luisa (tutor), true (authorsendemail).

Subjects/Keywords: VIH (Virus); VIH (Viruses); Pèptids; Péptidos; Peptides; Fluorescència; Fluorescencia; Fluorescence; Ciències de la Salut; 615

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Galatola, R. (2014). Péptidos derivados del GB virus C como potenciales inhibidores del virus de la inmunodeficiencia humana tipo 1. (Thesis). Universitat de Barcelona. Retrieved from http://hdl.handle.net/10803/130895

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Galatola, Ramona. “Péptidos derivados del GB virus C como potenciales inhibidores del virus de la inmunodeficiencia humana tipo 1.” 2014. Thesis, Universitat de Barcelona. Accessed January 15, 2021. http://hdl.handle.net/10803/130895.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Galatola, Ramona. “Péptidos derivados del GB virus C como potenciales inhibidores del virus de la inmunodeficiencia humana tipo 1.” 2014. Web. 15 Jan 2021.

Vancouver:

Galatola R. Péptidos derivados del GB virus C como potenciales inhibidores del virus de la inmunodeficiencia humana tipo 1. [Internet] [Thesis]. Universitat de Barcelona; 2014. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10803/130895.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Galatola R. Péptidos derivados del GB virus C como potenciales inhibidores del virus de la inmunodeficiencia humana tipo 1. [Thesis]. Universitat de Barcelona; 2014. Available from: http://hdl.handle.net/10803/130895

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université de Montréal

18. Milot, David-Martin. Évaluation du besoin et de la pertinence de l'implantation d'un service d'injection supervisée en Montérégie.

Degree: 2015, Université de Montréal

URL: http://hdl.handle.net/1866/11821

Subjects/Keywords: Service d’injection supervisée (SIS); Montérégie; Usagers de drogues par injection (UDI); Substances psychoactives; Drogue; Injection; Seringue; Virus de l’immunodéficience humaine (VIH); Virus de l’hépatite C (VHC); Sans domicile fixe; Supervised injection facility (SIF); Injection drug users (IDU); Substance use; Drug; Syringe; Human immunodeficiency virus (HIV); Hepatitis C virus (HCV); Homeless; Health Sciences - Public Health / Sciences de la santé - Santé publique (UMI : 0573)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Milot, D. (2015). Évaluation du besoin et de la pertinence de l'implantation d'un service d'injection supervisée en Montérégie. (Thesis). Université de Montréal. Retrieved from http://hdl.handle.net/1866/11821

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Milot, David-Martin. “Évaluation du besoin et de la pertinence de l'implantation d'un service d'injection supervisée en Montérégie.” 2015. Thesis, Université de Montréal. Accessed January 15, 2021. http://hdl.handle.net/1866/11821.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Milot, David-Martin. “Évaluation du besoin et de la pertinence de l'implantation d'un service d'injection supervisée en Montérégie.” 2015. Web. 15 Jan 2021.

Vancouver:

Milot D. Évaluation du besoin et de la pertinence de l'implantation d'un service d'injection supervisée en Montérégie. [Internet] [Thesis]. Université de Montréal; 2015. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/1866/11821.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Milot D. Évaluation du besoin et de la pertinence de l'implantation d'un service d'injection supervisée en Montérégie. [Thesis]. Université de Montréal; 2015. Available from: http://hdl.handle.net/1866/11821

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universitat de Barcelona

19. Fernández Carrillo, Carlos. Nuevos factores del hospedador en la fisiopatología y la respuesta al tratamiento antiviral de la infección por el virus de la hepatitis C.

Degree: 2017, Universitat de Barcelona

URL: http://hdl.handle.net/10803/586384

► Using Translational Medicine, in this work we studied 2 key host elements in HCV infection: P-bodies and IFNL4/IFNL3 SNPs. CONCLUSIONS: 1. HCV infection impairs P-bodies… (more)

Subjects/Keywords: Virus de l'hepatitis C; Virus de la hepatitis C; Hepatitis C virus; Interferó; Interferón; Interferon; Ciències de la Salut; 616.9

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fernández Carrillo, C. (2017). Nuevos factores del hospedador en la fisiopatología y la respuesta al tratamiento antiviral de la infección por el virus de la hepatitis C. (Thesis). Universitat de Barcelona. Retrieved from http://hdl.handle.net/10803/586384

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fernández Carrillo, Carlos. “Nuevos factores del hospedador en la fisiopatología y la respuesta al tratamiento antiviral de la infección por el virus de la hepatitis C.” 2017. Thesis, Universitat de Barcelona. Accessed January 15, 2021. http://hdl.handle.net/10803/586384.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fernández Carrillo, Carlos. “Nuevos factores del hospedador en la fisiopatología y la respuesta al tratamiento antiviral de la infección por el virus de la hepatitis C.” 2017. Web. 15 Jan 2021.

Vancouver:

Fernández Carrillo C. Nuevos factores del hospedador en la fisiopatología y la respuesta al tratamiento antiviral de la infección por el virus de la hepatitis C. [Internet] [Thesis]. Universitat de Barcelona; 2017. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10803/586384.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fernández Carrillo C. Nuevos factores del hospedador en la fisiopatología y la respuesta al tratamiento antiviral de la infección por el virus de la hepatitis C. [Thesis]. Universitat de Barcelona; 2017. Available from: http://hdl.handle.net/10803/586384

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université de Grenoble

20. Sturm, Nathalie. Etude phénotypique et fonctionnelle des lymphocytes intra-hépatiques dans l'hépatite chronique virale C et le carcinome hépatocellulaire : Phenotypic and functional study of intrahepatic lymphocytic infiltrate in chronic viral C hepatitis and hepatocellular carcinoma.

Degree: Docteur es, Virologie microbiologie immunologie, 2011, Université de Grenoble

URL: http://www.theses.fr/2011GRENV056

►

L'hépatite chronique virale C est associée à une défaillance du système immunitaire. Nous nous sommes intéressés aux cellules NK et aux lymphocytes Treg, partenaires de… (more)

▼

L'hépatite chronique virale C est associée à une défaillance du système immunitaire. Nous nous sommes intéressés aux cellules NK et aux lymphocytes Treg, partenaires de la réponse immunitaire innée. Le nombre des NK, particulièrement les CD56dim, est significativement diminué chez les patients infectés, dans le foie plus que dans le sang, et s'accentue avec la fibrogenèse. Le nombre de CD3-CD56+brightNKG2A+ circulantes est corrélé à la sévérité de l'inflammation et de la fibrose et celui des CD3-CD56+dimNKG2A+ inversement corrélé à la charge virale. Les NK sont fonctionnelles, en capacité de produire de l'IFN-γ et d'engager un processus de cytolyse. L'expression de CD158 est significativement diminuée à la surface des NK hépatiques mais conservée dans les NK circulantes. L'expression de NKG2A,C,D dans les NK circulantes et hépatiques est identique à celles de patients non infectés. Les Treg intrahépatiques FoxP3+ sont quasi-exclusivement de phénotype CD4+. En analyse multivariée, le nombre de FoxP3+ est indépendamment associé à celui de CD8+, surtout dans les lésions nécrotico-inflammatoires et une corrélation forte est observée entre les transcrits CD8, FoxP3, IL-10 et TGF-β, suggérant que les Treg bloquent l'expansion et la cytotoxicité des TCD8 par contact cellulaire ou par le biais de cytokines immunosuppressives. L'équilibre entre FoxP3 et CD8 est rompu dans les grades et stades Métavir A>2 et F>3, avec un effondrement du rapport FoxP3/CD8. L'inflammation hépatique chronique s'accompagne de fibrose, aboutissant à la cirrhose, principale cause de CHC. Dans les cirrhoses virales C avec ou sans CHC, les lymphocytes CD3+, CD4+, CD8+, CD20+, CD56+, TCRγδ +, FoxP3+ sont plus nombreux dans la fibrose que dans le parenchyme. Le nombre de CD20+, CD3+, CD4+, CD8+ et l'expression d'IFN-γ et RANTES sont plus élevés dans les cirrhoses qui développent un CHC. En analyse multivariée, CD8 est le seul facteur indépendament associé à la récidive tumorale et à une diminution de la survie sans récidive à 5 ans. Les CD20+, CD3+, CD4+, CD8+, CD56+, TCRγδ+, FoxP3+ sont significativement moins nombreux dans le CHC que dans la cirrhose. Mais les FoxP3+ sont significativement plus nombreux et les CD56+ moins nombreux dans le CHC que dans le nodule parenchymateux, sans modification des LT, conduisant à une augmentation du rapport FoxP3/CD8 dans la tumeur. Les CD56+ diminuent de la cirrhose au CHC. Aucune corrélation n'est observée entre la densité intra-tumorale des lymphocytes étudiés et la récidive carcinomateuse. Conclusion. Un infiltrat inflammatoire dense au sein de la cirrhose C, particulièrement riche en CD8, favorise le développement et/ou la récidive du CHC.

Chronic hepatitis C is associated with the failure of the immune system. We were interested to NK cells and Treg cells, partners in the innate immune response. The number of NK, particularly the CD56+dim, is significantly reduced in infected patients, in the liver more than in the blood, and increases during the process of fibrogenesis. The number of circulating CD3-…

Advisors/Committee Members: Zarski, Jean-Pierre (thesis director), Marche, Patrice (thesis director).

Subjects/Keywords: Virus de l’hépatite C (VHC); Fibrose hépatique; Inflammation; Lymphocytes (T,Natural Killer,T régulateur); Immunohistochimie. Protéomie tissulaire; Hepatitis C virus; Liver fibrosis; Inflammation; Lymphocytes (T,Natural killer,T regulatory); Immunohistochemistry. Tissular proteomic analysis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sturm, N. (2011). Etude phénotypique et fonctionnelle des lymphocytes intra-hépatiques dans l'hépatite chronique virale C et le carcinome hépatocellulaire : Phenotypic and functional study of intrahepatic lymphocytic infiltrate in chronic viral C hepatitis and hepatocellular carcinoma. (Doctoral Dissertation). Université de Grenoble. Retrieved from http://www.theses.fr/2011GRENV056

Chicago Manual of Style (16^th Edition):

Sturm, Nathalie. “Etude phénotypique et fonctionnelle des lymphocytes intra-hépatiques dans l'hépatite chronique virale C et le carcinome hépatocellulaire : Phenotypic and functional study of intrahepatic lymphocytic infiltrate in chronic viral C hepatitis and hepatocellular carcinoma.” 2011. Doctoral Dissertation, Université de Grenoble. Accessed January 15, 2021. http://www.theses.fr/2011GRENV056.

MLA Handbook (7^th Edition):

Sturm, Nathalie. “Etude phénotypique et fonctionnelle des lymphocytes intra-hépatiques dans l'hépatite chronique virale C et le carcinome hépatocellulaire : Phenotypic and functional study of intrahepatic lymphocytic infiltrate in chronic viral C hepatitis and hepatocellular carcinoma.” 2011. Web. 15 Jan 2021.

Vancouver:

Sturm N. Etude phénotypique et fonctionnelle des lymphocytes intra-hépatiques dans l'hépatite chronique virale C et le carcinome hépatocellulaire : Phenotypic and functional study of intrahepatic lymphocytic infiltrate in chronic viral C hepatitis and hepatocellular carcinoma. [Internet] [Doctoral dissertation]. Université de Grenoble; 2011. [cited 2021 Jan 15]. Available from: http://www.theses.fr/2011GRENV056.

Council of Science Editors:

Sturm N. Etude phénotypique et fonctionnelle des lymphocytes intra-hépatiques dans l'hépatite chronique virale C et le carcinome hépatocellulaire : Phenotypic and functional study of intrahepatic lymphocytic infiltrate in chronic viral C hepatitis and hepatocellular carcinoma. [Doctoral Dissertation]. Université de Grenoble; 2011. Available from: http://www.theses.fr/2011GRENV056

21. Grandal Fustes, Marta. Caracterización epidemiológica y virológica en pacientes con infección crónica por el Virus de la Hepatitis C: impacto en el tratamiento con antivirales de acción directa .

Degree: 2019, Universidad da Coruña

URL: http://hdl.handle.net/2183/24358

► [Resumen] La infección por el Virus de la Hepatitis C (VHC) es un problema grave de salud pública mundial, que actualmente afecta a más de… (more)

Subjects/Keywords: Virus de la hepatitis C; Hepatitis C-Tratamiento; Antivirales-Investigación

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APA (6^th Edition):

Grandal Fustes, M. (2019). Caracterización epidemiológica y virológica en pacientes con infección crónica por el Virus de la Hepatitis C: impacto en el tratamiento con antivirales de acción directa . (Doctoral Dissertation). Universidad da Coruña. Retrieved from http://hdl.handle.net/2183/24358

Chicago Manual of Style (16^th Edition):

Grandal Fustes, Marta. “Caracterización epidemiológica y virológica en pacientes con infección crónica por el Virus de la Hepatitis C: impacto en el tratamiento con antivirales de acción directa .” 2019. Doctoral Dissertation, Universidad da Coruña. Accessed January 15, 2021. http://hdl.handle.net/2183/24358.

MLA Handbook (7^th Edition):

Grandal Fustes, Marta. “Caracterización epidemiológica y virológica en pacientes con infección crónica por el Virus de la Hepatitis C: impacto en el tratamiento con antivirales de acción directa .” 2019. Web. 15 Jan 2021.

Vancouver:

Grandal Fustes M. Caracterización epidemiológica y virológica en pacientes con infección crónica por el Virus de la Hepatitis C: impacto en el tratamiento con antivirales de acción directa . [Internet] [Doctoral dissertation]. Universidad da Coruña; 2019. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2183/24358.

Council of Science Editors:

Grandal Fustes M. Caracterización epidemiológica y virológica en pacientes con infección crónica por el Virus de la Hepatitis C: impacto en el tratamiento con antivirales de acción directa . [Doctoral Dissertation]. Universidad da Coruña; 2019. Available from: http://hdl.handle.net/2183/24358

22. Margusino Framiñán, Luis. Efectividad y seguridad de los antivirales de acción directa frente al virus de la hepatitis C: foco en subpoblaciones especiales .

Degree: 2020, Universidad da Coruña

URL: http://hdl.handle.net/2183/26574

► [Resumen] El virus de la hepatitis C (VHC) es un virus ácido ribonucleico (ARN) monocatenario identificado como el agente etiológico de la hepatitis C. El… (more)

Subjects/Keywords: Antivirales-Investigación; Hepatitis C-Tratamiento; Virus de la hepatitis C

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APA (6^th Edition):

Margusino Framiñán, L. (2020). Efectividad y seguridad de los antivirales de acción directa frente al virus de la hepatitis C: foco en subpoblaciones especiales . (Doctoral Dissertation). Universidad da Coruña. Retrieved from http://hdl.handle.net/2183/26574

Chicago Manual of Style (16^th Edition):

Margusino Framiñán, Luis. “Efectividad y seguridad de los antivirales de acción directa frente al virus de la hepatitis C: foco en subpoblaciones especiales .” 2020. Doctoral Dissertation, Universidad da Coruña. Accessed January 15, 2021. http://hdl.handle.net/2183/26574.

MLA Handbook (7^th Edition):

Margusino Framiñán, Luis. “Efectividad y seguridad de los antivirales de acción directa frente al virus de la hepatitis C: foco en subpoblaciones especiales .” 2020. Web. 15 Jan 2021.

Vancouver:

Margusino Framiñán L. Efectividad y seguridad de los antivirales de acción directa frente al virus de la hepatitis C: foco en subpoblaciones especiales . [Internet] [Doctoral dissertation]. Universidad da Coruña; 2020. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2183/26574.

Council of Science Editors:

Margusino Framiñán L. Efectividad y seguridad de los antivirales de acción directa frente al virus de la hepatitis C: foco en subpoblaciones especiales . [Doctoral Dissertation]. Universidad da Coruña; 2020. Available from: http://hdl.handle.net/2183/26574

23. Villegas Chiroque, Miguel. Factores predictivos de respuesta al tratamiento contra la hepatitis C crónica en pacientes atendidos en el Hospital Militar Central Lima Perú, 2006-2011.

Degree: 2013, National University of San Marcos

URL: http://hdl.handle.net/20.500.12672/3409

► – We performed a retrospective study of cases and controls to assess predictors of efficacy of combination therapy with pegylated interferon alpha (Peg IFN-) and… (more)

Subjects/Keywords: Hepatitis C - Tratamiento; Virus de la hepatitis C

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APA (6^th Edition):

Villegas Chiroque, M. (2013). Factores predictivos de respuesta al tratamiento contra la hepatitis C crónica en pacientes atendidos en el Hospital Militar Central Lima Perú, 2006-2011. (Thesis). National University of San Marcos. Retrieved from http://hdl.handle.net/20.500.12672/3409

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Villegas Chiroque, Miguel. “Factores predictivos de respuesta al tratamiento contra la hepatitis C crónica en pacientes atendidos en el Hospital Militar Central Lima Perú, 2006-2011.” 2013. Thesis, National University of San Marcos. Accessed January 15, 2021. http://hdl.handle.net/20.500.12672/3409.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Villegas Chiroque, Miguel. “Factores predictivos de respuesta al tratamiento contra la hepatitis C crónica en pacientes atendidos en el Hospital Militar Central Lima Perú, 2006-2011.” 2013. Web. 15 Jan 2021.

Vancouver:

Villegas Chiroque M. Factores predictivos de respuesta al tratamiento contra la hepatitis C crónica en pacientes atendidos en el Hospital Militar Central Lima Perú, 2006-2011. [Internet] [Thesis]. National University of San Marcos; 2013. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/20.500.12672/3409.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Villegas Chiroque M. Factores predictivos de respuesta al tratamiento contra la hepatitis C crónica en pacientes atendidos en el Hospital Militar Central Lima Perú, 2006-2011. [Thesis]. National University of San Marcos; 2013. Available from: http://hdl.handle.net/20.500.12672/3409

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

24. BRITO, Rodrigo José Videres Cordeiro de. Perfil epidemiológico e genotípico dos pacientes com infecção crônica pelo vírus hepatite C do norte do Estado da Bahia .

Degree: 2009, Universidade Federal de Pernambuco

URL: http://repositorio.ufpe.br/handle/123456789/17107

► Esta dissertação de mestrado é composta por uma revisão bibliográfica sobre as formas de transmissão do HCV e um artigo original, a ser submetido a… (more)

Subjects/Keywords: Hepatite C; VHC; Gluconergan®; Fatores de risco; Hepatitis C; HCV; Gluconergan®; Risck fator

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

BRITO, R. J. V. C. d. (2009). Perfil epidemiológico e genotípico dos pacientes com infecção crônica pelo vírus hepatite C do norte do Estado da Bahia . (Thesis). Universidade Federal de Pernambuco. Retrieved from http://repositorio.ufpe.br/handle/123456789/17107

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

BRITO, Rodrigo José Videres Cordeiro de. “Perfil epidemiológico e genotípico dos pacientes com infecção crônica pelo vírus hepatite C do norte do Estado da Bahia .” 2009. Thesis, Universidade Federal de Pernambuco. Accessed January 15, 2021. http://repositorio.ufpe.br/handle/123456789/17107.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

BRITO, Rodrigo José Videres Cordeiro de. “Perfil epidemiológico e genotípico dos pacientes com infecção crônica pelo vírus hepatite C do norte do Estado da Bahia .” 2009. Web. 15 Jan 2021.

Vancouver:

BRITO RJVCd. Perfil epidemiológico e genotípico dos pacientes com infecção crônica pelo vírus hepatite C do norte do Estado da Bahia . [Internet] [Thesis]. Universidade Federal de Pernambuco; 2009. [cited 2021 Jan 15]. Available from: http://repositorio.ufpe.br/handle/123456789/17107.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

BRITO RJVCd. Perfil epidemiológico e genotípico dos pacientes com infecção crônica pelo vírus hepatite C do norte do Estado da Bahia . [Thesis]. Universidade Federal de Pernambuco; 2009. Available from: http://repositorio.ufpe.br/handle/123456789/17107

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

25. Head, Timothy. Top quark spin correlations and leptonic forward-backward asymmetries at D0.

Degree: 2013, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:187750

► The top quark is the heaviest fundamental particle. Its correspondingly short lifetime implies that it will decay before top flavoured hadrons can form. This provides… (more)

Subjects/Keywords: HEP

…top quark decays. The most recent measurement by D0 finds 0.90 < Vtb < 0.99 at 95% C. L… …them into the impossible. — Arthur C. Clarke 8 Chapter 1 Introduction The field of… …the application of particle physics’ model to systems with few constituent particles… …model which successfully describes why the sun shines and what happened in the earliest… …moments of the history of the universe. It is referred to as the standard model. With a mass…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Head, T. (2013). Top quark spin correlations and leptonic forward-backward asymmetries at D0. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:187750

Chicago Manual of Style (16^th Edition):

Head, Timothy. “Top quark spin correlations and leptonic forward-backward asymmetries at D0.” 2013. Doctoral Dissertation, University of Manchester. Accessed January 15, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:187750.

MLA Handbook (7^th Edition):

Head, Timothy. “Top quark spin correlations and leptonic forward-backward asymmetries at D0.” 2013. Web. 15 Jan 2021.

Vancouver:

Head T. Top quark spin correlations and leptonic forward-backward asymmetries at D0. [Internet] [Doctoral dissertation]. University of Manchester; 2013. [cited 2021 Jan 15]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:187750.

Council of Science Editors:

Head T. Top quark spin correlations and leptonic forward-backward asymmetries at D0. [Doctoral Dissertation]. University of Manchester; 2013. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:187750

Université Catholique de Louvain

26. François, Brieuc. Search for resonant di-Higgs production in CMS and development of a model independent approach to look for new physics at the LHC.

Degree: 2017, Université Catholique de Louvain

URL: http://hdl.handle.net/2078.1/191754

►

Despite the numerous experimental confirmations of the Standard Model (SM), this framework is believed not to be the complete theory of fundamental interactions. Many scenarios… (more)

Subjects/Keywords: HEP; CMS

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APA (6^th Edition):

François, B. (2017). Search for resonant di-Higgs production in CMS and development of a model independent approach to look for new physics at the LHC. (Thesis). Université Catholique de Louvain. Retrieved from http://hdl.handle.net/2078.1/191754

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

François, Brieuc. “Search for resonant di-Higgs production in CMS and development of a model independent approach to look for new physics at the LHC.” 2017. Thesis, Université Catholique de Louvain. Accessed January 15, 2021. http://hdl.handle.net/2078.1/191754.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

François, Brieuc. “Search for resonant di-Higgs production in CMS and development of a model independent approach to look for new physics at the LHC.” 2017. Web. 15 Jan 2021.

Vancouver:

François B. Search for resonant di-Higgs production in CMS and development of a model independent approach to look for new physics at the LHC. [Internet] [Thesis]. Université Catholique de Louvain; 2017. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2078.1/191754.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

François B. Search for resonant di-Higgs production in CMS and development of a model independent approach to look for new physics at the LHC. [Thesis]. Université Catholique de Louvain; 2017. Available from: http://hdl.handle.net/2078.1/191754

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manchester

27. Head, Timothy. Top quark spin correlations and leptonic forward-backward asymmetries at D0.

Degree: PhD, 2013, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/top-quark-spin-correlations-and-leptonic-forwardbackward-asymmetries-at-d0(a07247a9-4eac-4bc4-8c1f-48c9316e90aa).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.574354

► The top quark is the heaviest fundamental particle. Its correspondingly short lifetime implies that it will decay before top flavoured hadrons can form. This provides… (more)

Subjects/Keywords: 539.7216; HEP

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Head, T. (2013). Top quark spin correlations and leptonic forward-backward asymmetries at D0. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/top-quark-spin-correlations-and-leptonic-forwardbackward-asymmetries-at-d0(a07247a9-4eac-4bc4-8c1f-48c9316e90aa).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.574354

Chicago Manual of Style (16^th Edition):

Head, Timothy. “Top quark spin correlations and leptonic forward-backward asymmetries at D0.” 2013. Doctoral Dissertation, University of Manchester. Accessed January 15, 2021. https://www.research.manchester.ac.uk/portal/en/theses/top-quark-spin-correlations-and-leptonic-forwardbackward-asymmetries-at-d0(a07247a9-4eac-4bc4-8c1f-48c9316e90aa).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.574354.

MLA Handbook (7^th Edition):

Head, Timothy. “Top quark spin correlations and leptonic forward-backward asymmetries at D0.” 2013. Web. 15 Jan 2021.

Vancouver:

Head T. Top quark spin correlations and leptonic forward-backward asymmetries at D0. [Internet] [Doctoral dissertation]. University of Manchester; 2013. [cited 2021 Jan 15]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/top-quark-spin-correlations-and-leptonic-forwardbackward-asymmetries-at-d0(a07247a9-4eac-4bc4-8c1f-48c9316e90aa).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.574354.

Council of Science Editors:

Head T. Top quark spin correlations and leptonic forward-backward asymmetries at D0. [Doctoral Dissertation]. University of Manchester; 2013. Available from: https://www.research.manchester.ac.uk/portal/en/theses/top-quark-spin-correlations-and-leptonic-forwardbackward-asymmetries-at-d0(a07247a9-4eac-4bc4-8c1f-48c9316e90aa).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.574354

28. Verga-Gerard, Amandine. Perturbation de la voie de signalisation du TGF-β par les protéines du virus de l'hépatite C , impact sur la carcinogenèse : Disruption of TGFβ signaling pathway by hepatitis C virus proteins, impact on carcinogenesis.

Degree: Docteur es, Sciences de la vie, 2012, Lyon, École normale supérieure

URL: http://www.theses.fr/2012ENSL0785

►

L’infection chronique par le virus de l’hépatite C (VHC) conduit au développement de pathologies hépatiques, telles que la fibrose dont le terme évolutif est la… (more)

▼

L’infection chronique par le virus de l’hépatite C (VHC) conduit au développement de pathologies hépatiques, telles que la fibrose dont le terme évolutif est la cirrhose sur laquelle peut se développer un carcinome hépatocellulaire. Les observations cliniques indiquent que le VHC interfère avec la voie de signalisation du Transforming Growth Factor β (TGFβ). Entre autres fonctions, cette cytokine induit la transition épithélio-mésenchymateuse (EMT), ce qui favorise la migration cellulaire et l'invasion tumorale. Le but de cette thèse est d'analyser l'impact des protéines non structurales du VHC sur la voie de signalisation du TGFβ.Nous avons montré que le réplicon subgénomique du VHC induit une augmentation de la signalisation du TGFβ résultant en une plus forte expression de gènes associés à l’EMT et induisant un phénotype d’EMT. L’expression de la protéase virale NS3-4A seule, augmente et prolonge la phosphorylation de Smad2/3 en aval du récepteur du TGFβ et renforce l’expression de certains gènes cibles du TGFβ. L’analyse des interactions entre les protéines du VHC et les protéines de la voie du TGFβ a permis d’identifier l’interaction entre NS3-4A et la protéine Smurf2. Le réplicon subgénomique ou la protéase NS3-4A ont des rôles antagonistes à la protéine Smurf2 sur la voie de signalisation du TGFβ. L’analyse globale des gènes régulés par le TGFβ dans les cellules exprimant le réplicon subgénomique a permis d’identifier, que dans ces cellules, le TGFβ induit une réponse pro-tumorale.Ces résultats montrent que NS3-4A induit une plus forte réponse des cellules au TGFβ, en inhibant la fonction de Smurf2 dans le rétrocontrôle négatif de la voie du TGFβ. Ce nouveau mécanisme d’interférence du VHC avec la voie du TGFβ pourrait contribuer à l’EMT des cellules hépatocytaires infectées favorisant ainsi la cancérisation. Ce travail apporte de nouvelles pistes dans la compréhension des mécanismes associés à la cancérisation chez les patients chroniquement infectés par le VHC.

Chronic infection by hepatitis C virus (HCV) leads to the development of hepatic diseases like fibrosis which evolves into cirrhosis on which can develop hepatocellular carcinoma. Clinical observations indicate that HCV interferes with the TGFβ signaling pathway. Among other functions this cytokine induces epithelial-to-mesenchymal transition (EMT) promoting cell migration and tumor invasion. The aim of this study is to analyze the impact of HCV non structural proteins on TGFβ signaling pathway. We have demonstrated that the HCV subgenomic replicon induces an enhancement of the TGFβ signaling pathway resulting in a strong expression of EMT associated genes and inducing EMT phenotype. The expression of the NS3-4A viral protein alone enhances and stabilizes Smad2/3 phosphorylation downstream TGFβ receptor and increases the expression of some TGFβ target genes. The analysis of interactions between HCV proteins and proteins of the TGFβ signaling pathway has shown the interaction of NS3-4A with Smurf2 protein. HCV subgenomic replicon and NS3-4A have…

Advisors/Committee Members: Lotteau, Vincent (thesis director).

Subjects/Keywords: Virus de l'hépatite C (VHC); Voie de signalisation du TGFβ; Smurf2; Carcinome hépato-cellulaire; Hepatits C virus (HCV); TGFβ signaling pathway; Smurf2; Hepatocellular carcinoma

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Verga-Gerard, A. (2012). Perturbation de la voie de signalisation du TGF-β par les protéines du virus de l'hépatite C , impact sur la carcinogenèse : Disruption of TGFβ signaling pathway by hepatitis C virus proteins, impact on carcinogenesis. (Doctoral Dissertation). Lyon, École normale supérieure. Retrieved from http://www.theses.fr/2012ENSL0785

Chicago Manual of Style (16^th Edition):

Verga-Gerard, Amandine. “Perturbation de la voie de signalisation du TGF-β par les protéines du virus de l'hépatite C , impact sur la carcinogenèse : Disruption of TGFβ signaling pathway by hepatitis C virus proteins, impact on carcinogenesis.” 2012. Doctoral Dissertation, Lyon, École normale supérieure. Accessed January 15, 2021. http://www.theses.fr/2012ENSL0785.

MLA Handbook (7^th Edition):

Verga-Gerard, Amandine. “Perturbation de la voie de signalisation du TGF-β par les protéines du virus de l'hépatite C , impact sur la carcinogenèse : Disruption of TGFβ signaling pathway by hepatitis C virus proteins, impact on carcinogenesis.” 2012. Web. 15 Jan 2021.

Vancouver:

Verga-Gerard A. Perturbation de la voie de signalisation du TGF-β par les protéines du virus de l'hépatite C , impact sur la carcinogenèse : Disruption of TGFβ signaling pathway by hepatitis C virus proteins, impact on carcinogenesis. [Internet] [Doctoral dissertation]. Lyon, École normale supérieure; 2012. [cited 2021 Jan 15]. Available from: http://www.theses.fr/2012ENSL0785.

Council of Science Editors:

Verga-Gerard A. Perturbation de la voie de signalisation du TGF-β par les protéines du virus de l'hépatite C , impact sur la carcinogenèse : Disruption of TGFβ signaling pathway by hepatitis C virus proteins, impact on carcinogenesis. [Doctoral Dissertation]. Lyon, École normale supérieure; 2012. Available from: http://www.theses.fr/2012ENSL0785

29. Silva, Ana Lúcia Bernardes da. O papel das mutações do gene HFE e da sobrecarga de ferro na evolução da hepatite crônica pelo VHC.

Degree: Mestrado, Gastroenterologia Clínica, 2009, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5147/tde-08122009-181724/ ;

► Introdução: A infecção pelo VHC é uma epidemia de proporções globais, que se torna crônica em cerca de 85% dos indivíduos. Sobrecarga de ferro secundária… (more)

Subjects/Keywords: Fibrose; Fibrosis; HCV; Hemocromatose hereditária; Hereditary hemochromatosis; HFE; HFE; Iron overload; Sobrecarga de ferro; VHC

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Silva, A. L. B. d. (2009). O papel das mutações do gene HFE e da sobrecarga de ferro na evolução da hepatite crônica pelo VHC. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5147/tde-08122009-181724/ ;

Chicago Manual of Style (16^th Edition):

Silva, Ana Lúcia Bernardes da. “O papel das mutações do gene HFE e da sobrecarga de ferro na evolução da hepatite crônica pelo VHC.” 2009. Masters Thesis, University of São Paulo. Accessed January 15, 2021. http://www.teses.usp.br/teses/disponiveis/5/5147/tde-08122009-181724/ ;.

MLA Handbook (7^th Edition):

Silva, Ana Lúcia Bernardes da. “O papel das mutações do gene HFE e da sobrecarga de ferro na evolução da hepatite crônica pelo VHC.” 2009. Web. 15 Jan 2021.

Vancouver:

Silva ALBd. O papel das mutações do gene HFE e da sobrecarga de ferro na evolução da hepatite crônica pelo VHC. [Internet] [Masters thesis]. University of São Paulo; 2009. [cited 2021 Jan 15]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5147/tde-08122009-181724/ ;.

Council of Science Editors:

Silva ALBd. O papel das mutações do gene HFE e da sobrecarga de ferro na evolução da hepatite crônica pelo VHC. [Masters Thesis]. University of São Paulo; 2009. Available from: http://www.teses.usp.br/teses/disponiveis/5/5147/tde-08122009-181724/ ;

Université Laval

30. Tremblay, Myriam. Caractérisation de l'expression des isoformes du DCIR dans l'infection par le VIH-1.

Degree: 2019, Université Laval

URL: http://hdl.handle.net/20.500.11794/37545

►

Le DCIR, une lectine de type C, a été identifié comme un facteur facilitant le transfert des virus des cellules dendritiques vers les lymphocytes TCD4… (more)

▼

Le DCIR, une lectine de type C, a été identifié comme un facteur facilitant le transfert des virus des cellules dendritiques vers les lymphocytes TCD4 lors de l’infection au VIH-1. Cinq isoformes différentes du DCIR existent. L’expression de certaines isoformes peut être modulée de façon indépendante dans certaines pathologies. L’hypothèse qui a été posée est que les isoformes du DCIR sont modulées au cours de l’infection au VIH-1 et qu’il est possible de générer des cellules déficientes en DCIR par la technique de CRISPR/Cas9. Les objectifs étaient de développer une PCR quantitative spécifique pour chaque isoforme du DCIR, de quantifier l’expression des isoformes du DCIR dans des cellules immunitaires de patients infectés par le VIH-1, de déterminer s’il existe des corrélations entre le patron d’expression de chaque isoforme et les données cliniques des patients VIH-1 et, finalement, de développer un outil CRISPR/Cas9 permettant le knock-out du gène du DCIR dans des cellules souches hématopoïétiques. Les résultats montrent que l’expression des isoformes 1 à 4 n’est pas modulée par l’infection au VIH-1. Cependant, une corrélation existe entre le ratio CD4/CD8 des patients traités et l’expression de l’isoforme 1 du DCIR dans les cellules polynucléées. De plus, dans les cellules mononucléées sanguines périphériques, les isoformes 1 et 3 du DCIR sont les plus exprimées et, dans les cellules sanguines polynucléées, l’isoforme 1 du DCIR est la plus exprimée. Finalement, un outil CRISPR/Cas9, permettant d’inactiver le gène du DCIR dans des cellules souches hématopoïétiques par infection lentivirale, a été développé. Ces données permettront de mieux caractériser les rôles des isoformes du DCIR, contribuant ainsi au développement de stratégies thérapeutiques ciblant cette lectine.

The C type lectin DCIR was identified as viral transfer factor from dendritic cells to CD4 T cells during HIV-1 infection. There are five known isoforms of the DCIR protein. The expression of some of these isoforms can be modulated independently in some pathologies. The hypothesis of this project is that DCIR isoforms can be modulated during HIV-1 infection and that it is possible to generate DCIR deficient cells with CRISPR/Cas9 technology. Our objectives were: to develop a specific quantitative PCR for each isoforms of DCIR; to quantify the expression of DCIR isoforms in immune cells of HIV-1 infected patients; to determine if there are correlations between the expression pattern of each isoform and the patients’ clinical data and; to develop a CRISPR/Cas9 tool allowing the knock out of the DCIR gene in hematopoietic stem cells. The results show that the expression of DCIR isoforms 1 to 4 is not modulated by HIV-1 infection. However, a positive correlation exists between the CD4/CD8 T cell ratio of treated HIV-1 patients and the expression of DCIR isoform 1 in polymorphonuclear cells. Furthermore, the DCIR isoforms 1 and 3 are the most expressed isoforms in the patients’ peripheral blood mononuclear cells, while the DCIR isoform 1 is the most…

Advisors/Committee Members: Gilbert, Caroline.

Subjects/Keywords: Lectines de type C; Isoformes; Virus de l'immunodéficience humaine de type 1; Infections à VIH

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tremblay, M. (2019). Caractérisation de l'expression des isoformes du DCIR dans l'infection par le VIH-1. (Thesis). Université Laval. Retrieved from http://hdl.handle.net/20.500.11794/37545

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tremblay, Myriam. “Caractérisation de l'expression des isoformes du DCIR dans l'infection par le VIH-1.” 2019. Thesis, Université Laval. Accessed January 15, 2021. http://hdl.handle.net/20.500.11794/37545.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tremblay, Myriam. “Caractérisation de l'expression des isoformes du DCIR dans l'infection par le VIH-1.” 2019. Web. 15 Jan 2021.

Vancouver:

Tremblay M. Caractérisation de l'expression des isoformes du DCIR dans l'infection par le VIH-1. [Internet] [Thesis]. Université Laval; 2019. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/20.500.11794/37545.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tremblay M. Caractérisation de l'expression des isoformes du DCIR dans l'infection par le VIH-1. [Thesis]. Université Laval; 2019. Available from: http://hdl.handle.net/20.500.11794/37545

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Open Access Theses and Dissertations