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Univerzitet u Beogradu
1.
Ćetković-Milisavljević, Mila V., 1970-.
Analiza mikrovaskularizacije i imunohistohemijskih
karakteristika ganglijskih i ektopičnih ganglijskih ćelija
trigeminalnog nerva.
Degree: Medicinski fakultet, 2015, Univerzitet u Beogradu
URL: https://fedorabg.bg.ac.rs/fedora/get/o:7882/bdef:Content/get 
► Histologija i embriologija / Histology and Embryology
Posebne mikromorfološke karakteristike vaskularizacije trigeminalnog nerva i gangliona i bliski neurovaskularni odnosi sa okolnim sudovima, kao i njihov…
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▼ Histologija i embriologija / Histology and
Embryology
Posebne mikromorfološke karakteristike
vaskularizacije trigeminalnog nerva i gangliona i bliski
neurovaskularni odnosi sa okolnim sudovima, kao i njihov mogući
klinički značaj bili su prvi razlozi ove studije. Drugi cilj
studije bio je da se prouče morfološke i imunohistohemijske
karakteristike ektopičnih i ganglijskih neurona u trigeminalnom
nervu i ganglionu. Krvni sudovi 25 trigeminalnih nerava odraslih
osoba, posle injiciranja mešavine tuša i želatina u arterijski
sistem, mikrodisekovani su i proučavani pod stereomikroskopom.
Četrdeset humanih trigeminalnih nerava i gangliona poreklom od 20
osoba, dobijenih rutinskom obdukcijom, proučavani su posle
histološkog bojenja metodom Klüver-Barrera, trihromnih bojenja Azan
i Masson tehnikom i imunohistohemijskih reakcija na neke od
neuronskih markera, neuropeptida i neurotransmitera. Trigeminalne
grančice namenjene nervu, od dve do pet, polazile su od dve ili tri
od sledećih arterija: superolateralna pontinska (92%), a. cerebelli
inferior anterior (ACIA) (88%), inferolateralna pontinska (72%) i
a. cerebelli superior (ACS) (12%). Trigeminalne arterijice su bile
prosečnog prečnika od 0,220 mm. Jedan sud je vaskularizovao bilo
motorni deo trigeminalnog stabla, ili senzorni deo ili oba.
Trigeminalni sudovi su formirali proksimalni i distalni arterijski
prsten oko nerva. Proksimalni prsten se nalazio u nivou spoja
korenog dela nerva i ponsa. Njegove centralne grane su pratile
trigeminalni nerv na putu ka glavnom senzornom i motornom jedru,
dok su periferne longitudinalne grančice pratile snopove nerva ka
ganglionu. Distalni arterijski prsten, često nekompletan, obuhvatao
je središnji deo nerva, neposredno pre njegovog ulaska u arahnoidni
omotač. Najčešće uočen neurovaskularni kontakt trigeminalnog nerva
bio je sa ACS (20%), sa petroznom ili Dendijevom venom (24%) i sa
ACIA (12%). Inferolateralno stablo i meningohipofizialno stablo,
koja polaze od unutrašnje karotidne arterije, kao i grane srednje
moždanične arterije su bili glavni sudovi koji su vaskularizovali
trigeminalni ganglion. Trigeminalne arterijice koje su od njih
polazile su bile prosečnog prečnika od 0,220 mm...
Advisors/Committee Members: Antunović, Vaso, 1949-.
Subjects/Keywords: trigeminal nerve; trigeminal ganglion; trigeminal
arteries; petrosal vein; trigeminal neuralgia; displaced neurons;
ganglion cell; satellite cell; immunohistochemistry
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APA (6th Edition):
Ćetković-Milisavljević, Mila V., 1. (2015). Analiza mikrovaskularizacije i imunohistohemijskih
karakteristika ganglijskih i ektopičnih ganglijskih ćelija
trigeminalnog nerva. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:7882/bdef:Content/get
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Ćetković-Milisavljević, Mila V., 1970-. “Analiza mikrovaskularizacije i imunohistohemijskih
karakteristika ganglijskih i ektopičnih ganglijskih ćelija
trigeminalnog nerva.” 2015. Thesis, Univerzitet u Beogradu. Accessed January 19, 2021.
https://fedorabg.bg.ac.rs/fedora/get/o:7882/bdef:Content/get.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Ćetković-Milisavljević, Mila V., 1970-. “Analiza mikrovaskularizacije i imunohistohemijskih
karakteristika ganglijskih i ektopičnih ganglijskih ćelija
trigeminalnog nerva.” 2015. Web. 19 Jan 2021.
Vancouver:
Ćetković-Milisavljević, Mila V. 1. Analiza mikrovaskularizacije i imunohistohemijskih
karakteristika ganglijskih i ektopičnih ganglijskih ćelija
trigeminalnog nerva. [Internet] [Thesis]. Univerzitet u Beogradu; 2015. [cited 2021 Jan 19].
Available from: https://fedorabg.bg.ac.rs/fedora/get/o:7882/bdef:Content/get.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Ćetković-Milisavljević, Mila V. 1. Analiza mikrovaskularizacije i imunohistohemijskih
karakteristika ganglijskih i ektopičnih ganglijskih ćelija
trigeminalnog nerva. [Thesis]. Univerzitet u Beogradu; 2015. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:7882/bdef:Content/get
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
2.
Sneh, Gabriel.
Older Patients Have Better Pain Outcomes Following Microvascular Decompression for Trigeminal Neuralgia.
Degree: Doctor of Medicine, 2018, Harvard University
URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:41973532
► Introduction: Trigeminal neuralgia (TN) is a debilitating facial pain syndrome characterized by paroxysmal attacks of pain in the distribution of the trigeminal nerve. Microvascular decompression…
(more)
▼ Introduction: Trigeminal neuralgia (TN) is a debilitating facial pain syndrome characterized by paroxysmal attacks of pain in the distribution of the trigeminal nerve. Microvascular decompression (MVD) is a neurosurgical intervention that can be used to treat trigeminal neuralgia in patients whose symptoms remain refractory to medical management, or in whom the side effects of medication outweigh its benefits. While the safety of MVD for TN has been demonstrated in patients of all age groups, there is relative less research that demonstrates the efficacy of MVD for TN in older patients. In this study, we sought to evaluate the relationship between age and efficacy of MVD for TN in patients with a history of typical trigeminal neuralgia and who had demonstrated neurovascular compression on preoperative imaging.
Methods: A retrospective case series was performed. 124 subjects with a history of typical trigeminal neuralgia were recruited who underwent microvascular decompression at MGH between January 2004 and December 2013. Patients were divided into two groups based upon age—those 60 years of age or older, and those less than 60 years of age—and their TN-related pain both pre- and post-MVD was quantified using the Barrow Neurologic Institute pain score.
Results: Older patients were found to have a significantly lower pain score following MVD relative to patients in the younger group, as well as a significantly greater decrease in their TN-related pain score from pre- to post-MVD compared to patients in the younger age group.
Conclusion: Microvascular decompression for trigeminal neuralgia appears to be more effective in older patients, relative to those that are less than 60 years of age. MVD should be considered for older patients with TN who are appropriate surgical candidates.
Scholarly Project
Subjects/Keywords: Trigeminal Neuralgia; Microvascular decompression; Age
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APA (6th Edition):
Sneh, G. (2018). Older Patients Have Better Pain Outcomes Following Microvascular Decompression for Trigeminal Neuralgia. (Doctoral Dissertation). Harvard University. Retrieved from http://nrs.harvard.edu/urn-3:HUL.InstRepos:41973532
Chicago Manual of Style (16th Edition):
Sneh, Gabriel. “Older Patients Have Better Pain Outcomes Following Microvascular Decompression for Trigeminal Neuralgia.” 2018. Doctoral Dissertation, Harvard University. Accessed January 19, 2021.
http://nrs.harvard.edu/urn-3:HUL.InstRepos:41973532.
MLA Handbook (7th Edition):
Sneh, Gabriel. “Older Patients Have Better Pain Outcomes Following Microvascular Decompression for Trigeminal Neuralgia.” 2018. Web. 19 Jan 2021.
Vancouver:
Sneh G. Older Patients Have Better Pain Outcomes Following Microvascular Decompression for Trigeminal Neuralgia. [Internet] [Doctoral dissertation]. Harvard University; 2018. [cited 2021 Jan 19].
Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:41973532.
Council of Science Editors:
Sneh G. Older Patients Have Better Pain Outcomes Following Microvascular Decompression for Trigeminal Neuralgia. [Doctoral Dissertation]. Harvard University; 2018. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:41973532
University of Toronto
3.
DeSouza, Danielle D.
Structural Abnormalities and Treatment-related Plasticity in Classical Trigeminal Neuralgia.
Degree: PhD, 2015, University of Toronto
URL: http://hdl.handle.net/1807/69282
► Classical trigeminal neuralgia (TN) is a unique neuropathic pain disorder characterized by highly intense electric shock-like attacks of unilateral facial pain. While TN is commonly…
(more)
▼ Classical
trigeminal neuralgia (TN) is a unique neuropathic pain disorder characterized by highly intense electric shock-like attacks of unilateral facial pain. While TN is commonly associated with neurovascular compression of the
trigeminal nerve at the root entry zone (REZ) its pathophysiology is not well understood. In conjunction with
trigeminal nerve abnormalities, central gray matter and white matter (GM, WM) structure may be affected and/or contribute to the maintenance of TN. Surgical treatment for TN may produce analgesia by effectively normalizing these structural abnormalities. The main aim of this thesis is to determine if there are structural neural abnormalities in patients with TN and whether effective neurosurgical treatment can reverse these abnormalities. The specific aims were to determine: 1) if patients with TN have brain GM abnormalities; 2) if patients with TN have
trigeminal nerve and/or brain WM abnormalities based on multiple DTI-derived metrics; 3) if effective neurosurgical treatment for TN is associated with a reversal of the
trigeminal REZ and cortical and subcortical GM abnormalities that we report in studies 1 and 2 of this thesis. In groups of TN patients with right-sided pain and healthy age- and sex-matched controls, magnetic resonance imaging revealed that patients had: 1) increased GM in the sensory thalamus, amygdala, periaqueductal gray, basal ganglia, contralateral primary somatosensory cortex, and frontal pole and less GM in the pregenual anterior cingulate cortex, insula, and orbitofrontal cortex; 2) abnormalities in the
trigeminal REZ and cerebral WM tracts including the corpus callosum, cingulum, corona radiata, and superior longitudinal fasciculus; and 3) a reversal ventral anterior insula and
trigeminal REZ abnormalities following effective treatment, with the degree of REZ normalization correlating with pain relief. Taken together, this thesis demonstrates for the first time both
trigeminal nerve and brain abnormalities in patients with TN, and the impact of effective treatment on these abnormalities.
Advisors/Committee Members: Davis, Karen D., Hodaie, Mojgan, Medical Science.
Subjects/Keywords: brain plasticity; MRI; neuroimaging; pain; trigeminal nerve; trigeminal neuralgia; 0566
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APA (6th Edition):
DeSouza, D. D. (2015). Structural Abnormalities and Treatment-related Plasticity in Classical Trigeminal Neuralgia. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/69282
Chicago Manual of Style (16th Edition):
DeSouza, Danielle D. “Structural Abnormalities and Treatment-related Plasticity in Classical Trigeminal Neuralgia.” 2015. Doctoral Dissertation, University of Toronto. Accessed January 19, 2021.
http://hdl.handle.net/1807/69282.
MLA Handbook (7th Edition):
DeSouza, Danielle D. “Structural Abnormalities and Treatment-related Plasticity in Classical Trigeminal Neuralgia.” 2015. Web. 19 Jan 2021.
Vancouver:
DeSouza DD. Structural Abnormalities and Treatment-related Plasticity in Classical Trigeminal Neuralgia. [Internet] [Doctoral dissertation]. University of Toronto; 2015. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/1807/69282.
Council of Science Editors:
DeSouza DD. Structural Abnormalities and Treatment-related Plasticity in Classical Trigeminal Neuralgia. [Doctoral Dissertation]. University of Toronto; 2015. Available from: http://hdl.handle.net/1807/69282
4.
酒井, 翔悟.
Modulation of excitability of trigeminal neurons during electrical stimulation of the superior laryngeal nerve in anesthetized rabbits : 麻酔下ウサギにおける上喉頭神経刺激時三叉神経ニューロンの興奮性変調.
Degree: 博士（歯学）, 2016, Niigata University / 新潟大学
URL: http://hdl.handle.net/10191/42120
► 学位の種類: 博士（歯学）. 報告番号: 甲第4153号. 学位記番号: 新大院博（歯）甲第351号. 学位授与年月日: 平成28年3月23日
The present study investigated the effect of electrical stimulation of the superior laryngeal nerve (SLN) on evoked…
(more)
▼ 学位の種類: 博士（歯学）. 報告番号: 甲第4153号. 学位記番号: 新大院博（歯）甲第351号. 学位授与年月日: 平成28年3月23日
The present study investigated the effect of electrical stimulation of the superior laryngeal nerve (SLN) on evoked potentials from trigeminal interneurons. Experiments were carried out on 19 rabbits anesthetized with urethane. Single-unit responses evoked by electrical stimulation of the inferior alveolar nerve were recorded in the trigeminal nucleus. To evoke swallowing reflex, the SLN was electrically stimulated (train pulses; 0.2 ms, 30 Hz). Current intensity of SLN stimulation was set at 2, 4, or 8 times the threshold for evoking swallowing reflex at least once for 10 s. Initiation and change in latency were compared among the periods (before, during, and after SLN stimulation) or among stimulus intensities. Inhibition of evoked responses and delay in latency was observed in 15 of 27 identified neurons (55.6%) and 26/27 (96.3%) neurons, respectively, either during or after SLN stimulation. The rate of inhibition of evoked responses was significantly different among SLN stimulus intensities. Modulated neurons were divided into two groups based on latency, short (< 3 ms) or long (>= 3 ms). Longer latencies resulted in longer delays. Eighteen neurons (66.7%) were found to project to the digastric motor nucleus. Most neurons were distributed in the main sensory trigeminal nucleus or subnucleus-γ of the oral nucleus of the spinal trigeminal tract. These results suggest that sensory information originating from the orofacial region, possibly related to the jaw reflex, was inhibited during or after SLN stimulation possibly by input from the swallowing central pattern generator.
Subjects/Keywords: trigeminal interneuron; swallow; superior laryngeal nerve
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APA (6th Edition):
酒井, . (2016). Modulation of excitability of trigeminal neurons during electrical stimulation of the superior laryngeal nerve in anesthetized rabbits : 麻酔下ウサギにおける上喉頭神経刺激時三叉神経ニューロンの興奮性変調. (Thesis). Niigata University / 新潟大学. Retrieved from http://hdl.handle.net/10191/42120
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
酒井, 翔悟. “Modulation of excitability of trigeminal neurons during electrical stimulation of the superior laryngeal nerve in anesthetized rabbits : 麻酔下ウサギにおける上喉頭神経刺激時三叉神経ニューロンの興奮性変調.” 2016. Thesis, Niigata University / 新潟大学. Accessed January 19, 2021.
http://hdl.handle.net/10191/42120.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
酒井, 翔悟. “Modulation of excitability of trigeminal neurons during electrical stimulation of the superior laryngeal nerve in anesthetized rabbits : 麻酔下ウサギにおける上喉頭神経刺激時三叉神経ニューロンの興奮性変調.” 2016. Web. 19 Jan 2021.
Vancouver:
酒井 . Modulation of excitability of trigeminal neurons during electrical stimulation of the superior laryngeal nerve in anesthetized rabbits : 麻酔下ウサギにおける上喉頭神経刺激時三叉神経ニューロンの興奮性変調. [Internet] [Thesis]. Niigata University / 新潟大学; 2016. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/10191/42120.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
酒井 . Modulation of excitability of trigeminal neurons during electrical stimulation of the superior laryngeal nerve in anesthetized rabbits : 麻酔下ウサギにおける上喉頭神経刺激時三叉神経ニューロンの興奮性変調. [Thesis]. Niigata University / 新潟大学; 2016. Available from: http://hdl.handle.net/10191/42120
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Vanderbilt University
5.
Sawyer, Eva Kille.
Comparative Neuroanatomy of the Mammalian Trigeminal Somatosensory System.
Degree: PhD, Neuroscience, 2016, Vanderbilt University
URL: http://hdl.handle.net/1803/12716
► The trigeminal somatosensory system conveys the sense of touch to the face. Most mammals have specialized tactile hairs, or whiskers, on their cheeks and chin…
(more)
▼ The
trigeminal somatosensory system conveys the sense of touch to the face. Most mammals have specialized tactile hairs, or whiskers, on their cheeks and chin that mediate tactile exploration of their environment. These whiskers are innervated by the
trigeminal nerve, and the mechanosensory signals that nerve conveys are sent first to the
trigeminal somatosensory nuclei in the brainstem (the principal sensory nucleus and the spinal
trigeminal nucleus), relayed to the ventroposterior medial nucleus of the thalamus, and from there sent to the face region of the primary somatosensory cortex. This pathway is best studied in laboratory rodents, where the facial whiskers are represented in each of the stations in the brainstem, thalamus and cortex in an anatomically visible array of circular modules that represent each whisker in a one-to-one fashion. However, knowledge of this pathway in other mammals is lacking. Information on this pathway in other species is crucial to understanding whether the knowledge gained in the rodent system is applicable somatosensory organization in other mammals. Here, I investigate the
trigeminal somatosensory specializations in three non-traditional research animals that, together, cover a broad array of phenotypes for facial touch. These are the California sea lion (Zalophus californianus), the star-nosed mole (Condylura cristata), and the northern greater galago (Otolemur garnetti). In each case, I compare what I learn to what is known in the laboratory rodents. I find the anatomically distinct segments are represented in various stations in all these mammals. This suggests that at the level of forming somatosensory maps of the periphery, particularly in the brainstem and thalamus, mammals share many of the same basic rules for brain organization.
Advisors/Committee Members: Douglas Abbot (committee member), Kenneth Catania (committee member), Jon Kaas (committee member), Vivien Casagrande (Committee Chair).
Subjects/Keywords: barrelettes; whiskers; comparative anatomy; trigeminal; touch; barrels
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APA (6th Edition):
Sawyer, E. K. (2016). Comparative Neuroanatomy of the Mammalian Trigeminal Somatosensory System. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/12716
Chicago Manual of Style (16th Edition):
Sawyer, Eva Kille. “Comparative Neuroanatomy of the Mammalian Trigeminal Somatosensory System.” 2016. Doctoral Dissertation, Vanderbilt University. Accessed January 19, 2021.
http://hdl.handle.net/1803/12716.
MLA Handbook (7th Edition):
Sawyer, Eva Kille. “Comparative Neuroanatomy of the Mammalian Trigeminal Somatosensory System.” 2016. Web. 19 Jan 2021.
Vancouver:
Sawyer EK. Comparative Neuroanatomy of the Mammalian Trigeminal Somatosensory System. [Internet] [Doctoral dissertation]. Vanderbilt University; 2016. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/1803/12716.
Council of Science Editors:
Sawyer EK. Comparative Neuroanatomy of the Mammalian Trigeminal Somatosensory System. [Doctoral Dissertation]. Vanderbilt University; 2016. Available from: http://hdl.handle.net/1803/12716
University of Illinois – Chicago
6.
LaVinka, Pamela C.
Trigeminal Nociception in the African Naked Mole-Rat: The Acid Test.
Degree: 2012, University of Illinois – Chicago
URL: http://hdl.handle.net/10027/9248
► Acidosis in the skin triggers activation of pain pathways, and behaviors indicative of pain in vertebrates. The exception is the naked mole-rat, the only known…
(more)
▼ Acidosis in the skin triggers activation of pain pathways, and behaviors indicative of pain in vertebrates. The exception is the naked mole-rat, the only known vertebrate to show physiological and behavioral insensitivity to acid pain in the skin. The goal of the present study was to determine behavioral and physiological responses of this species to airborne acidic fumes, which would be expected to affect the
trigeminal pain pathway in other species. Behaviorally, naked mole-rats did not avoid fumes from moderately high concentrations of acetic acid (10 and 20%), and c Fos labeling showed no increase in activity in the
trigeminal and vagal nuclei. In contrast, these concentrations triggered behavioral aversion and increased Fos activity in other laboratory rodents. For a very high concentration of acetic acid (50%), naked mole-rats showed significant avoidance behavior and increased Fos labeling in the vagus nucleus. However, there was no increase in
trigeminal labeling, and in fact, activity significantly decreased. This pattern is opposite of that associated with another irritant, ammonia fumes, which elicited an increase in
trigeminal but not vagal Fos labeling, and no behavioral avoidance. Behavioral avoidance of acidic fumes, but no increased labeling in the
trigeminal pain nucleus is consistent with the notion of adaptations to blunt acid pain, which would be advantageous for naked mole-rats as they normally live under chronically high levels of acidosis-inducing CO2.
Advisors/Committee Members: Murphy, Don (advisor), Park, Thomas J. (committee member), Malchow, Robert (committee member), Wirtshafter, Dave (committee member), Ragazzino, Michael (committee member).
Subjects/Keywords: naked mole-rat; pain; trigeminal; c Fos
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APA (6th Edition):
LaVinka, P. C. (2012). Trigeminal Nociception in the African Naked Mole-Rat: The Acid Test. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/9248
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
LaVinka, Pamela C. “Trigeminal Nociception in the African Naked Mole-Rat: The Acid Test.” 2012. Thesis, University of Illinois – Chicago. Accessed January 19, 2021.
http://hdl.handle.net/10027/9248.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
LaVinka, Pamela C. “Trigeminal Nociception in the African Naked Mole-Rat: The Acid Test.” 2012. Web. 19 Jan 2021.
Vancouver:
LaVinka PC. Trigeminal Nociception in the African Naked Mole-Rat: The Acid Test. [Internet] [Thesis]. University of Illinois – Chicago; 2012. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/10027/9248.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
LaVinka PC. Trigeminal Nociception in the African Naked Mole-Rat: The Acid Test. [Thesis]. University of Illinois – Chicago; 2012. Available from: http://hdl.handle.net/10027/9248
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Duke University
7.
Rodriguez, Erica Janet.
Uncovering a Monosynaptic Trigemino-parabrachial Circuit Facilitating Heightened Craniofacial Pain Perception
.
Degree: 2018, Duke University
URL: http://hdl.handle.net/10161/16790
► Humans often rank craniofacial pain as more severe than body pain. Evidence suggests that a stimulus of the same intensity induces stronger pain in…
(more)
▼ Humans often rank craniofacial pain as more severe than body pain. Evidence suggests that a stimulus of the same intensity induces stronger pain in the face than in the body. However, the underlying neural circuitry for the differential processing of facial versus bodily pain remains unknown. Interestingly, the lateral parabrachial nucleus (PBL), a critical node in the affective pain circuit, is activated more strongly by noxious stimulation of the face than of the hindpaw. Using a novel activity-dependent technology called CANE developed in our laboratory, we identified and selectively labeled noxious-stimulus-activated PBL neurons and performed comprehensive anatomical input–output mapping. Surprisingly, we uncovered a hitherto uncharacterized monosynaptic connection between cranial sensory neurons and the PBL-nociceptive neurons. Optogenetic activation of this monosynaptic craniofacial-to-PBL projection induced robust escape and avoidance behaviors and stress calls, whereas optogenetic silencing specifically reduced facial nociception. The monosynaptic circuit revealed here provides a neural substrate for heightened craniofacial affective pain.
Advisors/Committee Members: Wang, Fan (advisor).
Subjects/Keywords: Neurosciences;
Affective;
Circuits;
Craniofacial;
Pain;
Trigeminal
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APA (6th Edition):
Rodriguez, E. J. (2018). Uncovering a Monosynaptic Trigemino-parabrachial Circuit Facilitating Heightened Craniofacial Pain Perception
. (Thesis). Duke University. Retrieved from http://hdl.handle.net/10161/16790
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Rodriguez, Erica Janet. “Uncovering a Monosynaptic Trigemino-parabrachial Circuit Facilitating Heightened Craniofacial Pain Perception
.” 2018. Thesis, Duke University. Accessed January 19, 2021.
http://hdl.handle.net/10161/16790.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Rodriguez, Erica Janet. “Uncovering a Monosynaptic Trigemino-parabrachial Circuit Facilitating Heightened Craniofacial Pain Perception
.” 2018. Web. 19 Jan 2021.
Vancouver:
Rodriguez EJ. Uncovering a Monosynaptic Trigemino-parabrachial Circuit Facilitating Heightened Craniofacial Pain Perception
. [Internet] [Thesis]. Duke University; 2018. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/10161/16790.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Rodriguez EJ. Uncovering a Monosynaptic Trigemino-parabrachial Circuit Facilitating Heightened Craniofacial Pain Perception
. [Thesis]. Duke University; 2018. Available from: http://hdl.handle.net/10161/16790
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
8.
Stiles, Shannon Nicole.
Evaluation of Anti-Migraine Drugs in an in Vivo Rat Model of Chronic Migraine.
Degree: MSin Biology, Biology, 2015, Missouri State University
URL: https://bearworks.missouristate.edu/theses/1349
► Approximately 2% of the US population is affected by chronic migraine (CM). CM is a recurring, neurological disorder characterized by painful headache, along with autonomic,…
(more)
▼ Approximately 2% of the US population is affected by chronic migraine (CM). CM is a recurring, neurological disorder characterized by painful headache, along with autonomic, gastrointestinal, and other somatic symptoms. Prolonged sensitization of the
trigeminal system, which is implicated in CM, is comprised of peripheral primary
trigeminal ganglion neurons that provide sensory innervation of the head and face and second order neurons in the spinal
trigeminal nucleus (STN). The goal of my study was to evaluate anti-migraine drugs for their ability to inhibit ongoing peripheral and central sensitization of
trigeminal nociceptors. An in vivo animal model was used to determine if two novel drugs in development and Topiramate, a common drug used to treat frequent migraine, could inhibit nocifensive responses to mechanical stimulation of
trigeminal neurons. In addition, the
trigeminal ganglion and STN were evaluated on a molecular level to determine if the drugs could inhibit expression of a signaling protein implicated in peripheral and central sensitization. My results provide evidence that the two novel drugs significantly inhibited nocifensive responses and decreased expression of Protein Kinase A (PKA) in the
trigeminal ganglion and STN. In contrast, Topiramate did not decrease PKA expression and had no effect on nocifensive responses. Based on my findings, I conclude that these novel drugs may be beneficial in the treatment of CM.
Advisors/Committee Members: Paul Durham.
Subjects/Keywords: kinase; migraine; nociception; sensitization; trigeminal; Biology
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APA (6th Edition):
Stiles, S. N. (2015). Evaluation of Anti-Migraine Drugs in an in Vivo Rat Model of Chronic Migraine. (Masters Thesis). Missouri State University. Retrieved from https://bearworks.missouristate.edu/theses/1349
Chicago Manual of Style (16th Edition):
Stiles, Shannon Nicole. “Evaluation of Anti-Migraine Drugs in an in Vivo Rat Model of Chronic Migraine.” 2015. Masters Thesis, Missouri State University. Accessed January 19, 2021.
https://bearworks.missouristate.edu/theses/1349.
MLA Handbook (7th Edition):
Stiles, Shannon Nicole. “Evaluation of Anti-Migraine Drugs in an in Vivo Rat Model of Chronic Migraine.” 2015. Web. 19 Jan 2021.
Vancouver:
Stiles SN. Evaluation of Anti-Migraine Drugs in an in Vivo Rat Model of Chronic Migraine. [Internet] [Masters thesis]. Missouri State University; 2015. [cited 2021 Jan 19].
Available from: https://bearworks.missouristate.edu/theses/1349.
Council of Science Editors:
Stiles SN. Evaluation of Anti-Migraine Drugs in an in Vivo Rat Model of Chronic Migraine. [Masters Thesis]. Missouri State University; 2015. Available from: https://bearworks.missouristate.edu/theses/1349
9.
Denson, Jennifer Elise.
Investigation of Nocifensive and Cellular Effects of Dihydroergotamine in a Model of Chronic Migraine.
Degree: MSin Biology, Biology, 2015, Missouri State University
URL: https://bearworks.missouristate.edu/theses/1350
► The goal of my study was to investigate the nocifensive behavioral and cellular effects of dihydroergotamine (DHE) and sumatriptan in a model of sustained trigeminal…
(more)
▼ The goal of my study was to investigate the nocifensive behavioral and cellular effects of dihydroergotamine (DHE) and sumatriptan in a model of sustained
trigeminal activation.
Trigeminal nerves provide sensory innervation to the head and face and their activation has been implicated in migraine pathology. The most commonly prescribed medications for migraine treatment are the triptan class of drugs. However, triptans are not an effective therapy for all migraine patients and some develop triptan resistance. Ergot-derivatives, including DHE, could be a potential alternative for this subpopulation of patients. To cause activation of the
trigeminal system, adult male Sprague Dawley rats were given an inflammatory injection of complete Freund's adjuvant (CFA) or saline as a vehicle control in the temporomandibular joint capsule. Three and four days post-CFA-injection, intraperitoneal injections of DHE, sumatriptan, or vehicle control were delivered. I found that DHE, but not sumatriptan, was able to transiently inhibit CFA-mediated increases in nocifensive withdrawal behavior. Within the spinal cord, DHE was shown to inhibit CFA stimulated levels of the signaling protein PKA, which is known to promote central sensitization, and Iba1, a marker of activated microglial cells. However, both DHE and sumatriptan were able to inhibit stimulated levels of GFAP, a protein used as a marker of activated astrocytes. Results from my study provide evidence that DHE, but not sumatriptan, can inhibit nociception caused by prolonged activation of
trigeminal neurons and the inhibitory effect is likely to involve suppressing development of central sensitization. I propose that DHE may be therapeutically beneficial by blocking ongoing peripheral and central sensitization as characteristic of frequent episodic and chronic migraine.
Advisors/Committee Members: Paul Durham.
Subjects/Keywords: migraine; trigeminal; central sensitization; inflammation; nociception; Biology
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APA (6th Edition):
Denson, J. E. (2015). Investigation of Nocifensive and Cellular Effects of Dihydroergotamine in a Model of Chronic Migraine. (Masters Thesis). Missouri State University. Retrieved from https://bearworks.missouristate.edu/theses/1350
Chicago Manual of Style (16th Edition):
Denson, Jennifer Elise. “Investigation of Nocifensive and Cellular Effects of Dihydroergotamine in a Model of Chronic Migraine.” 2015. Masters Thesis, Missouri State University. Accessed January 19, 2021.
https://bearworks.missouristate.edu/theses/1350.
MLA Handbook (7th Edition):
Denson, Jennifer Elise. “Investigation of Nocifensive and Cellular Effects of Dihydroergotamine in a Model of Chronic Migraine.” 2015. Web. 19 Jan 2021.
Vancouver:
Denson JE. Investigation of Nocifensive and Cellular Effects of Dihydroergotamine in a Model of Chronic Migraine. [Internet] [Masters thesis]. Missouri State University; 2015. [cited 2021 Jan 19].
Available from: https://bearworks.missouristate.edu/theses/1350.
Council of Science Editors:
Denson JE. Investigation of Nocifensive and Cellular Effects of Dihydroergotamine in a Model of Chronic Migraine. [Masters Thesis]. Missouri State University; 2015. Available from: https://bearworks.missouristate.edu/theses/1350
10.
Tibano, Adriana Tanaka.
Alterações hemodinâmicas sistêmicas durante a compressão do gânglio trigeminal; com balão com ou sem bloqueio anestésico local.
Degree: PhD, Neurologia, 2011, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/5/5138/tde-27072011-173727/
;
► Foram avaliados os resultados, as alterações hemodinâmicas sistêmicas e as alterações da sensibilidade geral superficial de 31 doentes com neuralgia idiopática do trigêmeo tratados com…
(more)
▼ Foram avaliados os resultados, as alterações hemodinâmicas sistêmicas e as alterações da sensibilidade geral superficial de 31 doentes com neuralgia idiopática do trigêmeo tratados com a técnica de compressão percutânea do gânglio
trigeminal com balão sob anestesia geral associadamente ou não ao bloqueio anestésico do gânglio
trigeminal com lidocaína. As características biométricas, demográficas e clínicas foram similares nos doentes tratados (CBA) ou não (SBA) com bloqueio anestésico. As médias das pressões arteriais sistólicas (PASs), médias (PAMs) e diastólicas (PADs) e das frequências cardíacas foram analisadas nos momentos preoperatório imediato, anestesia geral e sem manipulação operatória, punção ganglionar, insuflação do balão e despertar e as sensibilidades faciais nos momentos pré-operatório e de 30 e 210 dias posoperatórios. As médias das PASs, das PAMs e das PADs foram inferiores nos doentes do grupo CBA em relação às dos doentes do grupo SBA nos momentos punção ganglionar e insuflação do balão do balão e as médias das PAMs e PADs foram inferiores nos doentes do grupo CBA em relação às do grupo SBA no momento despertar. Ocorreu elevação da PAS, PAM e PAD em todos os doentes hipertensos ou não do grupo SBA. Ocorreu elevação da PAM em 16,7% dos normotensos e em 33,3% dos hipertensos e em 33,3% dos normotensos e em 11,1% dos hipertensos do grupo CBA, respectivamente, nos momentos, punção ganglionar e insuflação do balão. Ocorreu hipertensão arterial em 50 a 75% dos doentes do grupo SBA e em zero a 7% dos doentes do grupo CBA nos momentos punção ganglionar e insuflação do balão. Todos os doentes normotensos do grupo CBA apresentaram redução da PAS e da PAM e, 83,3%, também da PAD no momento punção do gânglio
trigeminal. Ocorreu redução da PAS e da PAM em 83,3% dos doentes normotensos do grupo CBA e, em 66,7%, da PAD no momento insuflação do balão. Em 55,6% dos hipertensos do grupo CBA ocorreu redução das PAS e da PAM e, em 66,7%, da PAD no momento punção ganglionar. Observou-se redução da PAS em 66,7% dos doentes hipertensos do grupo CBA e da PAM e da PAS em 88,9%. Ocorreu redução da PAS e da PAM em 83,3% dos doentes normotensos do grupo CBA e da PAD em 66,7%. Ocorreu hipotensão arterial em 27% a 33% dos doentes do grupo CBA e em nenhum dos do grupo SBA. As frequências cardíacas dos doentes do grupo SBA elevaram-se e mantiveram-se mais elevadas que as dos do grupo CBA nos momentos anestesia geral sem manipulação operatória, punção ganglionar, insuflação do balão e despertar. Todos os doentes do grupo SBA e 90% dos do grupo CBA não apresentavam dor sete meses após a operação. Ocorreu recidiva da dor em 26,7% dos doentes; ocorreu em uma a 128 (71,13 ± 55,23) semanas após a cirurgia ou seja em 121,07 ± 23,05 semanas em média; não houve diferença estatisticamente significativa entre os doentes dos grupos SBA e CBA quanto à recidiva ou não da dor. Na avaliação de 30 e 210 dias, os valores da algiometria na região do segundo ramo (V2) do nervo trigêmeo nos doentes do grupo CBA foram mais elevados em ambos os lados…
Advisors/Committee Members: Siqueira, Silvia Regina Dowgan Tesseroli de, Teixeira, Manoel Jacobsen.
Subjects/Keywords: Gânglio trigêmeo; Hemodinâmica; Hemodynamic; Lidocaína; Lidocaine; Neuralgia do trigêmeo; Rizotomia; Rizotomy; Trigeminal ganglion; Trigeminal neuralgia
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APA (6th Edition):
Tibano, A. T. (2011). Alterações hemodinâmicas sistêmicas durante a compressão do gânglio trigeminal; com balão com ou sem bloqueio anestésico local. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5138/tde-27072011-173727/ ;
Chicago Manual of Style (16th Edition):
Tibano, Adriana Tanaka. “Alterações hemodinâmicas sistêmicas durante a compressão do gânglio trigeminal; com balão com ou sem bloqueio anestésico local.” 2011. Doctoral Dissertation, University of São Paulo. Accessed January 19, 2021.
http://www.teses.usp.br/teses/disponiveis/5/5138/tde-27072011-173727/ ;.
MLA Handbook (7th Edition):
Tibano, Adriana Tanaka. “Alterações hemodinâmicas sistêmicas durante a compressão do gânglio trigeminal; com balão com ou sem bloqueio anestésico local.” 2011. Web. 19 Jan 2021.
Vancouver:
Tibano AT. Alterações hemodinâmicas sistêmicas durante a compressão do gânglio trigeminal; com balão com ou sem bloqueio anestésico local. [Internet] [Doctoral dissertation]. University of São Paulo; 2011. [cited 2021 Jan 19].
Available from: http://www.teses.usp.br/teses/disponiveis/5/5138/tde-27072011-173727/ ;.
Council of Science Editors:
Tibano AT. Alterações hemodinâmicas sistêmicas durante a compressão do gânglio trigeminal; com balão com ou sem bloqueio anestésico local. [Doctoral Dissertation]. University of São Paulo; 2011. Available from: http://www.teses.usp.br/teses/disponiveis/5/5138/tde-27072011-173727/ ;
11.
Igawa, Kaori; Funahashi, Hideki; Miyahara, Yu; Naono-Nakayama, Rumi; Matsuo, Hisae; Yamashita, Yoshihiro; Sakoda, Sumio; Nishimori, Toshikazu.
Distribution of hemokinin-1 in the rat trigeminal ganglion and trigeminal sensory nuclear complex.
Degree: 博士(医学), 2017, University of Miyazaki / 宮崎大学
URL: http://hdl.handle.net/10458/6029
► 学位論文の一部を構成しているため、http://hdl.handle.net/10458/6028に本文を掲載。
Objective: A new mammalian tachykinin peptide encoded in a TAC4 gene was identified and designated as hemokinin-1 (HK-1). A representative of the tachykinin peptide…
(more)
▼ 学位論文の一部を構成しているため、http://hdl.handle.net/10458/6028に本文を掲載。
Objective: A new mammalian tachykinin peptide encoded in a TAC4 gene was identified and designated as hemokinin-1 (HK-1). A representative of the tachykinin peptide family is substance P (SP), and the function of SP has been well characterized as a pain transmitter or modulator, while it is possible that HK-1 is involved in pruriceptive processing, but, as yet, the distribution of HK-1 peptide in the trigeminal sensory system is still unknown. Thus, the aim of the present study was to elucidate the distribution of HK-1, while comparing the expression of SP, in the trigeminal ganglion and trigeminal sensory nuclear complex.## Design: The trigeminal ganglion and the brain stem of male SD rats were used in the immunohistochemical study. Since the amino acid sequence in the carboxyl-terminal regions of HK-1 and SP is common, polyclonal antibodies of HK-1 and SP derived from 6 amino acids consisting of amino-terminal regions of these peptides were produced in guinea pig and rabbit, respectively. The immunohistochemical staining of HK-1 and SP was conducted using frozen sections of the trigeminal ganglion and brain stem in rats.Results: Immunohistochemical studies revealed the expression of HK-1 in small- and medium-sized trigeminal ganglion neurons, in the paratrigeminal nucleus, and in lamina I of the trigeminal nucleus caudalis, while there was no immunoreactivity of HK-1 in the trigeminal nucleus principalis, trigeminal nucleus oralis, and trigeminal nucleus interpolaris. ### Conclusion: These findings indicate that HK-1 is a target molecule for treatment of itch in the orofaicial regions.
Subjects/Keywords: Hemokinin-1; Immunohistochemistry; Trigeminal sensory nuclear complex; Trigeminal ganglion; Pruritus; Substance P
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APA (6th Edition):
Igawa, Kaori; Funahashi, Hideki; Miyahara, Yu; Naono-Nakayama, Rumi; Matsuo, Hisae; Yamashita, Yoshihiro; Sakoda, Sumio; Nishimori, T. (2017). Distribution of hemokinin-1 in the rat trigeminal ganglion and trigeminal sensory nuclear complex. (Thesis). University of Miyazaki / 宮崎大学. Retrieved from http://hdl.handle.net/10458/6029
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Igawa, Kaori; Funahashi, Hideki; Miyahara, Yu; Naono-Nakayama, Rumi; Matsuo, Hisae; Yamashita, Yoshihiro; Sakoda, Sumio; Nishimori, Toshikazu. “Distribution of hemokinin-1 in the rat trigeminal ganglion and trigeminal sensory nuclear complex.” 2017. Thesis, University of Miyazaki / 宮崎大学. Accessed January 19, 2021.
http://hdl.handle.net/10458/6029.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Igawa, Kaori; Funahashi, Hideki; Miyahara, Yu; Naono-Nakayama, Rumi; Matsuo, Hisae; Yamashita, Yoshihiro; Sakoda, Sumio; Nishimori, Toshikazu. “Distribution of hemokinin-1 in the rat trigeminal ganglion and trigeminal sensory nuclear complex.” 2017. Web. 19 Jan 2021.
Vancouver:
Igawa, Kaori; Funahashi, Hideki; Miyahara, Yu; Naono-Nakayama, Rumi; Matsuo, Hisae; Yamashita, Yoshihiro; Sakoda, Sumio; Nishimori T. Distribution of hemokinin-1 in the rat trigeminal ganglion and trigeminal sensory nuclear complex. [Internet] [Thesis]. University of Miyazaki / 宮崎大学; 2017. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/10458/6029.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Igawa, Kaori; Funahashi, Hideki; Miyahara, Yu; Naono-Nakayama, Rumi; Matsuo, Hisae; Yamashita, Yoshihiro; Sakoda, Sumio; Nishimori T. Distribution of hemokinin-1 in the rat trigeminal ganglion and trigeminal sensory nuclear complex. [Thesis]. University of Miyazaki / 宮崎大学; 2017. Available from: http://hdl.handle.net/10458/6029
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
12.
Silva, Ricardo Eustáquio da.
Avaliação estrutural e quantitativa dos efeitos do envelhecimento sobre o gânglio trigeminal de ratos Wistar.
Degree: Mestrado, Anatomia dos Animais Domésticos e Silvestres, 2010, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/10/10132/tde-04022011-111947/
;
► O envelhecimento é uma falha progressiva nos processos fisiológicos celulares, produzindo alterações morfológicas nas células e nos tecidos. No sistema nervoso, produz uma redução no…
(more)
▼ O envelhecimento é uma falha progressiva nos processos fisiológicos celulares, produzindo alterações morfológicas nas células e nos tecidos. No sistema nervoso, produz uma redução no número de neurônios, nas fibras nervosas, principalmente nas arborizações dendríticas e nas espinhas sinápticas, e nas células da glia que, de acordo com sua localização e tipo celular, podem diminuir, permanecer constantes ou mesmo aumentar numericamente. Na presente pesquisa, avaliou-se os efeitos do envelhecimento sobre o gânglio trigeminal (GT) de ratos Wistar em animais jovens (2 meses de vida), adultos (12 meses de vida) e idosos (24 meses de vida). Os GT foram submetidos às técnicas histológicas da hematoxilina e eosina e Picro-sírius, onde avaliou-se, respectivamente, a densidade das células satélites glias (CGS) e o componente colágeno ganglionar. Através da técnica histoquímica da NADH-d, avaliou-se a área do perfil do GT, a área do perfil dos corpos celulares dos neurônios ganglionares e a densidade neuronal. Uma avaliação qualitativa foi também realizada relativamente à imunorreatividade dos neurônios ganglionares à substância P (SP) e ao peptídeo intestinal vasoativo (VIP). A densidade das CGS foi maior nos animais jovens do que nos animais adultos e idosos. Verificou-se, qualitativamente, que à medida que o animal envelhece há uma diminuição das fibras colágenas do tipo III, passando a predominar, nos animais idosos, as fibras do tipo I. A área do perfil celular dos corpos neuronais foi maior nos animais adultos sendo que em todos os grupos predominaram neurônios de tamanho médio, com a área do perfil celular entre 490 e 1100 μm2. A densidade neuronal apresentou-se maior nos animais jovens, e sem variações estatísticas entre os animais adultos e idosos. Em todos os grupos estudados, os neurônios pequenos foram os que apresentaram maior imunorreatividade à SP e ao VIP.
Aging is a progressive failure in cellular physiological processes. It determines morphological changes in cells of different tissues. In the nervous system, a reduction in neuron number and in neuron fibers, mainly in dendritic tree and synaptic, are described. With aging the glial cells may increase or decrease in number or also remain constant. In the present work the effects of aging were evaluated on the trigeminal ganglion (TG) comparing young (2 months age), adult (12 months age) and old rats (24 months age). Histological sections of TG were stained with hematoxilin-eosin technique to determine the density of satellite glial cells and Picro-sirius under polarized light to evaluate the Types I and III of collagen fibers. The NADH-diaphorase technique allowed determining the perycarion area. The immunoreactivity of ganglionar neurons to Substance P (SP) and vasoactive intestinal peptide (VIP) were also qualitatively evaluated. The glial cells density was higher in young and adult animals than in old animals. The type I collagen fibers predominates in ganglia of old animals whereas in the young animals is characteristic the presence of the type III…
Advisors/Committee Members: Liberti, Edson Aparecido.
Subjects/Keywords: Aging; Células satélites gliais; Collagen fibers; Envelhecimento; Fibras colágenas; Gânglio trigeminal; Immunohistochemistry; Imunohistoquímica; Satellite glial cells; Trigeminal ganglion
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APA ·
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Manager
APA (6th Edition):
Silva, R. E. d. (2010). Avaliação estrutural e quantitativa dos efeitos do envelhecimento sobre o gânglio trigeminal de ratos Wistar. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/10/10132/tde-04022011-111947/ ;
Chicago Manual of Style (16th Edition):
Silva, Ricardo Eustáquio da. “Avaliação estrutural e quantitativa dos efeitos do envelhecimento sobre o gânglio trigeminal de ratos Wistar.” 2010. Masters Thesis, University of São Paulo. Accessed January 19, 2021.
http://www.teses.usp.br/teses/disponiveis/10/10132/tde-04022011-111947/ ;.
MLA Handbook (7th Edition):
Silva, Ricardo Eustáquio da. “Avaliação estrutural e quantitativa dos efeitos do envelhecimento sobre o gânglio trigeminal de ratos Wistar.” 2010. Web. 19 Jan 2021.
Vancouver:
Silva REd. Avaliação estrutural e quantitativa dos efeitos do envelhecimento sobre o gânglio trigeminal de ratos Wistar. [Internet] [Masters thesis]. University of São Paulo; 2010. [cited 2021 Jan 19].
Available from: http://www.teses.usp.br/teses/disponiveis/10/10132/tde-04022011-111947/ ;.
Council of Science Editors:
Silva REd. Avaliação estrutural e quantitativa dos efeitos do envelhecimento sobre o gânglio trigeminal de ratos Wistar. [Masters Thesis]. University of São Paulo; 2010. Available from: http://www.teses.usp.br/teses/disponiveis/10/10132/tde-04022011-111947/ ;
UCLA
13.
Mulpuri, Yatendra.
Orofacial Pain Operant Analysis with Concomitant Investigation of Peripherally Restricted Cannabinoids and Nav1.8 Axonal Accumulation for the Potential Treatment of Neuropathic Pain.
Degree: Oral Biology, 2015, UCLA
URL: http://www.escholarship.org/uc/item/589470r8
► The primary emphasis of this dissertation project was to study the pathogenesis of neuropathic pain, and to develop new treatment strategies targeting primary sensory neurons…
(more)
▼ The primary emphasis of this dissertation project was to study the pathogenesis of neuropathic pain, and to develop new treatment strategies targeting primary sensory neurons of the pain pathway. Chronic neuropathic pain is debilitating and is maladaptive. Current treatment options are moderately effective with serious side-effects. Translational progress of novel drugs is impeded by side-effects, which is partly due to reliance on inaccurate methods of pain evaluation in animals. Our first step was to develop a novel behavioral assay for quantitation of spontaneous pain in an animal model. Results from this study showed that rats with trigeminal neuropathic pain had reduced drinking efficiency in an orofacial operant assay, whereas control rats maintained normal levels throughout testing. The second step of this project was to investigate novel peripherally restricted cannabinoids (PRCBs) for the effective treatment of neuropathic pain. Our initial testing in a rat model of sciatic nerve entrapment (SNE) revealed that, systemic administration of a PRCB (0.3 mg/kg) completely suppressed signs of mechanical allodynia between two and three hours. Based on this information, we conducted a preliminary pharmacokinetic study that showed peak plasma drug levels at 2 hrs after administration with negligible traces of drug in the brain and cerebro-spinal fluid (CSF). Subsequently, we tested these novel PRCBs for CNS side-effects due to central activation of cannabinoid receptor subtype 1 (CB1R). Systemic and oral administrations at therapeutic and higher doses showed complete lack of CNS side-effects. These side-effects prevailed after systemic administration of centrally acting cannabinoid, HU-210 in the same group of animals. Site specific administrations and further evaluation in orofacial operant assay confirmed that anti-allodynic actions of PRCB are mainly mediated at the periphery. Our in vitro data showed that PRCBs are full agonists at CB1R and partial agonists at CB2R. Co-administration of PRCB (1 mg/kg i.g.) with receptor specific antagonists revealed that anti-allodynic actions are largely mediated by CB1R. Since tolerance is of main concern with repeated use of chronic pain medications, we tested the anti-allodynic efficacy of PRCB during repeated oral administrations (1 mg/kg, i.g.) and found no appreciable tolerance after two weeks of testing. Western blot analysis showed stable levels of CB1R in the L4-L5 dorsal root ganglia (DRG) of these animals after repeated testing. The last research aim of this project was to investigate the axonal translocation of Nav1.8 mRNA after peripheral nerve injury. The hyperexcitability of afferent nociceptors is induced by axonal accumulation of certain ion channels and the role of Nav1.8 sodium channel is highly implicated. Therefore, we investigated the axonal translocation of Nav1.8 mRNA. Our qPCR data showed abnormal accumulation of Nav1.8 mRNA along with Nav1.6 and Nav1.9 mRNAs inthe injured infraorbital nerve. Since the 3’ untranslated region (UTR) is essential…
Subjects/Keywords: Dentistry; Neurosciences; Cannabinoids; Nav1.8; Neuropathic pain; Operant assay; Trigeminal
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APA (6th Edition):
Mulpuri, Y. (2015). Orofacial Pain Operant Analysis with Concomitant Investigation of Peripherally Restricted Cannabinoids and Nav1.8 Axonal Accumulation for the Potential Treatment of Neuropathic Pain. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/589470r8
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mulpuri, Yatendra. “Orofacial Pain Operant Analysis with Concomitant Investigation of Peripherally Restricted Cannabinoids and Nav1.8 Axonal Accumulation for the Potential Treatment of Neuropathic Pain.” 2015. Thesis, UCLA. Accessed January 19, 2021.
http://www.escholarship.org/uc/item/589470r8.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mulpuri, Yatendra. “Orofacial Pain Operant Analysis with Concomitant Investigation of Peripherally Restricted Cannabinoids and Nav1.8 Axonal Accumulation for the Potential Treatment of Neuropathic Pain.” 2015. Web. 19 Jan 2021.
Vancouver:
Mulpuri Y. Orofacial Pain Operant Analysis with Concomitant Investigation of Peripherally Restricted Cannabinoids and Nav1.8 Axonal Accumulation for the Potential Treatment of Neuropathic Pain. [Internet] [Thesis]. UCLA; 2015. [cited 2021 Jan 19].
Available from: http://www.escholarship.org/uc/item/589470r8.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mulpuri Y. Orofacial Pain Operant Analysis with Concomitant Investigation of Peripherally Restricted Cannabinoids and Nav1.8 Axonal Accumulation for the Potential Treatment of Neuropathic Pain. [Thesis]. UCLA; 2015. Available from: http://www.escholarship.org/uc/item/589470r8
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Mississippi State University
14.
Fizzano, Kristen Michelle.
Evaluation of a modified infraorbital approach for a maxillary nerve block for rhinoscopy with nasal biopsy of dogs.
Degree: MS, Veterinary Medicine, College of, 2017, Mississippi State University
URL: http://sun.library.msstate.edu/ETD-db/theses/available/etd-06222017-095553/
;
► A maxillary nerve block via a modified infraorbital approach, applied before rhinoscopy and nasal biopsy, would decrease nociception, minimize cardiorespiratory anesthetic effects, and improve…
(more)
▼ A maxillary nerve block via a modified infraorbital approach, applied before rhinoscopy and nasal biopsy, would decrease nociception, minimize cardiorespiratory anesthetic effects, and improve recoveries. In a crossover study, bupivacaine or equivalent volume of saline was administered to 8 healthy dogs via a modified infraorbital approach into each pterygopalatine region. Rhinoscopy and nasal biopsy were performed. Heart rate, blood pressure, plasma cortisol and norepinephrine concentrations, purposeful movement, and pain scores were monitored. Following a 14-day washout, dogs received the alternate treatment on the contralateral side. Blood pressures were significantly higher for the saline treatment than bupivacaine treatment. Plasma cortisol concentrations in the saline treatment were significantly higher 5 minutes after biopsy than at biopsy. No other parameters were significant. Using a maxillary nerve block via a modified infraorbital approach prior to rhinoscopy and nasal biopsy reduced procedural nociception. These findings warrant further evaluation in dogs with nasal disease.
Advisors/Committee Members: Todd Archer (chair), Robert Meyer (committee member), Robert Linford (committee member), Michaela Beasley (committee member), Brittany Thames (committee member).
Subjects/Keywords: trigeminal nerve; maxillary nerve; infraorbital; nerve block; rhinoscopy
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APA (6th Edition):
Fizzano, K. M. (2017). Evaluation of a modified infraorbital approach for a maxillary nerve block for rhinoscopy with nasal biopsy of dogs. (Masters Thesis). Mississippi State University. Retrieved from http://sun.library.msstate.edu/ETD-db/theses/available/etd-06222017-095553/ ;
Chicago Manual of Style (16th Edition):
Fizzano, Kristen Michelle. “Evaluation of a modified infraorbital approach for a maxillary nerve block for rhinoscopy with nasal biopsy of dogs.” 2017. Masters Thesis, Mississippi State University. Accessed January 19, 2021.
http://sun.library.msstate.edu/ETD-db/theses/available/etd-06222017-095553/ ;.
MLA Handbook (7th Edition):
Fizzano, Kristen Michelle. “Evaluation of a modified infraorbital approach for a maxillary nerve block for rhinoscopy with nasal biopsy of dogs.” 2017. Web. 19 Jan 2021.
Vancouver:
Fizzano KM. Evaluation of a modified infraorbital approach for a maxillary nerve block for rhinoscopy with nasal biopsy of dogs. [Internet] [Masters thesis]. Mississippi State University; 2017. [cited 2021 Jan 19].
Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-06222017-095553/ ;.
Council of Science Editors:
Fizzano KM. Evaluation of a modified infraorbital approach for a maxillary nerve block for rhinoscopy with nasal biopsy of dogs. [Masters Thesis]. Mississippi State University; 2017. Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-06222017-095553/ ;
Temple University
15.
Yang, Fan.
Amylin mediates brainstem control of heart rate in the diving reflex.
Degree: PhD, 2012, Temple University
URL: http://digital.library.temple.edu/u?/p245801coll10,193415
► Pharmacology
Amylin, or islet amyloid polypeptide is a 37-amino acid member of the calcitonin peptide family. Amylin role in the brainstem and its function in…
(more)
▼ Pharmacology
Amylin, or islet amyloid polypeptide is a 37-amino acid member of the calcitonin peptide family. Amylin role in the brainstem and its function in regulating heart rates is unknown. The diving reflex is a powerful autonomic reflex, however no neuropeptides have been described to modulate its function. In this thesis study, amylin expression in the brainstem involving pathways between the trigeminal ganglion and the nucleus ambiguus was visualized and characterized using immunohistochemistry. Its functional role in slowing heart rate and also its involvement in the diving reflex were elucidated using stereotaxic microinjection, whole-cel patch-clamp, and a rat diving model. Immunohistochemical and tract tracing studies in rats revealed amylin expression in trigeminal ganglion cells, which also contained vesicular glutamate transporter 2 positive. With respect to the brainstem, amylin containing fibers were discovered in spinal trigeminal tracts. These fibers curved dorsally toward choline acetyltransferase immunoreactive neurons of the nucleus ambiguus, suggesting that amylin may synapse to parasympathetic preganglionic neurons in the nucleus ambiguus. Microinjection of fluorogold to the nucleus ambiguus retrogradely labeled a population of trigeminal ganglion neurons; some of which also contained amylin. In urethane-anesthetized rats, stereotaxic microinjections of amylin to the nucleus ambiguus caused a dose-dependent bradycardia that was reversibly attenuated by microinjections of the selective amylin receptor antagonist, salmon calcitonin (8-32) (sCT (8-32)) or AC187, and abolished by bilateral vagotomy. In an anesthetized rat diving model, diving bradycardia was attenuated by glutamate receptor antagonists CNQX and AP5, and was further suppressed by AC187. Whole-cel patch-clamp recordings from cardiac preganglionic vagal neurons revealed that amylin depolarizes neurons while decreasing conductance. Amylin also resulted in a reduction in whole cell currents, consistent with the decrease in conductance. Amylin is also found to increase excitability of neurons. In the presence of TTX, spontaneous currents in cardiac preganglionic vagal neurons were observed to decrease in frequency in response to amylin while amplitude remained constant, signifying that amylin reduces presynaptic activity at cardiac preganglionic vagal neurons. Finally, evoked synaptic currents revealed that amylin decreases evoked currents, further demonstrating that amylin depolarization and increase in excitability of cardiac preganglionic vagal neurons is also associated with simultaneous inhibition of presynaptic transmission. Our study has demonstrated for the first time that the bradycardia elicited by the diving reflex is mediated by amylin from trigeminal ganglion cells projecting to cardiac preganglionic neurons in the nucleus ambiguus. Additionally, amylin results in the depolarization and increased excitability of cardiac preganglionic vagal neurons while inhibiting presynaptic transmission.
Temple University – Theses
Advisors/Committee Members: Dun, Nae J., Cowan, Alan, Liu-Chen, Lee-Yuan, Brailoiu, Gabriela C., Chong, Parkson Lee-Gau, Sapru, Hreday N..
Subjects/Keywords: Pharmacology; Neurosciences; amylin; bradycardia; diving reflex; neuropeptide; nucleus ambiguus; trigeminal ganglion
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APA (6th Edition):
Yang, F. (2012). Amylin mediates brainstem control of heart rate in the diving reflex. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,193415
Chicago Manual of Style (16th Edition):
Yang, Fan. “Amylin mediates brainstem control of heart rate in the diving reflex.” 2012. Doctoral Dissertation, Temple University. Accessed January 19, 2021.
http://digital.library.temple.edu/u?/p245801coll10,193415.
MLA Handbook (7th Edition):
Yang, Fan. “Amylin mediates brainstem control of heart rate in the diving reflex.” 2012. Web. 19 Jan 2021.
Vancouver:
Yang F. Amylin mediates brainstem control of heart rate in the diving reflex. [Internet] [Doctoral dissertation]. Temple University; 2012. [cited 2021 Jan 19].
Available from: http://digital.library.temple.edu/u?/p245801coll10,193415.
Council of Science Editors:
Yang F. Amylin mediates brainstem control of heart rate in the diving reflex. [Doctoral Dissertation]. Temple University; 2012. Available from: http://digital.library.temple.edu/u?/p245801coll10,193415
Universiteit Utrecht
16.
Koijck, L.A.
Multisensory Interactions between Olfaction and Touch: The Influence of the Trigeminal and Olfactory Sensation of an Odourant on Roughness Perception.
Degree: 2015, Universiteit Utrecht
URL: http://dspace.library.uu.nl:8080/handle/1874/311952
► In this study we investigated the influence of the olfactory and trigeminal sensation of an odourant on roughness perception. We expected that people would judge…
(more)
▼ In this study we investigated the influence of the olfactory and
trigeminal sensation of an odourant on roughness perception. We expected that people would judge the tactile surface roughness of four sandpapers as higher when they were exposed to a substance with a
trigeminal component (alcohol), and lower when they were exposed to Phenylethylalcohol (PEA, rose odour), compared to a no-odour (clean air) condition. Our results indicated that the participants could discriminate all four sandpapers on basis of their perceived roughness. However, there was no significant main effect of chemosensory and no significant interaction between chemosensory and sandpaper roughness. Despite the lack of significance, the results revealed that the mean rating responses on roughness were higher in the alcohol condition, and lower in the PEA-condition, compared to the no-odour condition. We also found a significant effect of gender for the roughness ratings in the PEA condition. Alternative explanations for the found results and suggestions for further research are discussed.
Advisors/Committee Members: Smeets, M., Donker, S..
Subjects/Keywords: multisensory interactions; olfaction; trigeminal; tactile perceptions; roughness; touch
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APA (6th Edition):
Koijck, L. A. (2015). Multisensory Interactions between Olfaction and Touch: The Influence of the Trigeminal and Olfactory Sensation of an Odourant on Roughness Perception. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/311952
Chicago Manual of Style (16th Edition):
Koijck, L A. “Multisensory Interactions between Olfaction and Touch: The Influence of the Trigeminal and Olfactory Sensation of an Odourant on Roughness Perception.” 2015. Masters Thesis, Universiteit Utrecht. Accessed January 19, 2021.
http://dspace.library.uu.nl:8080/handle/1874/311952.
MLA Handbook (7th Edition):
Koijck, L A. “Multisensory Interactions between Olfaction and Touch: The Influence of the Trigeminal and Olfactory Sensation of an Odourant on Roughness Perception.” 2015. Web. 19 Jan 2021.
Vancouver:
Koijck LA. Multisensory Interactions between Olfaction and Touch: The Influence of the Trigeminal and Olfactory Sensation of an Odourant on Roughness Perception. [Internet] [Masters thesis]. Universiteit Utrecht; 2015. [cited 2021 Jan 19].
Available from: http://dspace.library.uu.nl:8080/handle/1874/311952.
Council of Science Editors:
Koijck LA. Multisensory Interactions between Olfaction and Touch: The Influence of the Trigeminal and Olfactory Sensation of an Odourant on Roughness Perception. [Masters Thesis]. Universiteit Utrecht; 2015. Available from: http://dspace.library.uu.nl:8080/handle/1874/311952
Boston University
17.
Doheny, Jason.
Trigeminal neuropathic pain in rats: a role for thalamic hyperpolarization-activated cyclic nucleotide-gated channel activity.
Degree: MS, Medical Sciences, 2020, Boston University
URL: http://hdl.handle.net/2144/41212
► Trigeminal neuropathic pain (TNP) is a condition that occurs when one or more branches of the trigeminal nerve are insulted. Trigeminal neuropathic pain has been…
(more)
▼ Trigeminal neuropathic pain (TNP) is a condition that occurs when one or more branches of the
trigeminal nerve are insulted.
Trigeminal neuropathic pain has been shown to be refractory to treatment. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels regulate neuronal excitability in both the peripheral and central nerve systems. Emerging evidence indicates that HCN channels are involved in the development and maintenance of chronic pain, however, the impact of thalamic HCN channel activity on TNP has yet to be elucidated. In this report, we used a chronic constriction of the distal infraorbital nerve (dIoN-CCI) to induce TNP in rats. By infusing HCN channel blockers into the ventral posteromedial (VPM) nucleus of the thalamus in dIoN-CCI rats, we demonstrated that inhibition of HCN channel activity ameliorated TNP. We found that the HCN blocker ZD7288 and the clinical drug ivabradine dose-dependently attenuated both evoked and none-evoked nociceptive behaviors in dIoN-CCI rats. Electrophysiological measurements showed the expression of HCN current (Ih) in the thalamocortical neurons in the VPM was sensitive to the HCN channel modulator cyclic adenosine monophosphate (cAMP), suggesting a contribution of the HCN2 subunit in thalamic HCN current. In the thalamus, surface expression of the HCN2 subunit was increased in dIoN-CCI rats. Taken together, we propose that an increase in HCN channel activity in the thalamus in the ascending nociceptive pathway contributed to
trigeminal neuropathic pain.
Advisors/Committee Members: Franzblau, Carl (advisor), Mao, Jianren (advisor).
Subjects/Keywords: Medicine; dIoN-CCI; HCN channel; Neuropathic pain; Rats; Thalamus; Trigeminal neuralgia
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APA (6th Edition):
Doheny, J. (2020). Trigeminal neuropathic pain in rats: a role for thalamic hyperpolarization-activated cyclic nucleotide-gated channel activity. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/41212
Chicago Manual of Style (16th Edition):
Doheny, Jason. “Trigeminal neuropathic pain in rats: a role for thalamic hyperpolarization-activated cyclic nucleotide-gated channel activity.” 2020. Masters Thesis, Boston University. Accessed January 19, 2021.
http://hdl.handle.net/2144/41212.
MLA Handbook (7th Edition):
Doheny, Jason. “Trigeminal neuropathic pain in rats: a role for thalamic hyperpolarization-activated cyclic nucleotide-gated channel activity.” 2020. Web. 19 Jan 2021.
Vancouver:
Doheny J. Trigeminal neuropathic pain in rats: a role for thalamic hyperpolarization-activated cyclic nucleotide-gated channel activity. [Internet] [Masters thesis]. Boston University; 2020. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/2144/41212.
Council of Science Editors:
Doheny J. Trigeminal neuropathic pain in rats: a role for thalamic hyperpolarization-activated cyclic nucleotide-gated channel activity. [Masters Thesis]. Boston University; 2020. Available from: http://hdl.handle.net/2144/41212
Université Catholique de Louvain
18.
Huart, Caroline.
Novel psychophysical and electrophysiological tools to assess human olfactory function and evaluation of their potential for an early diagnosis of Alzheimer’s disease.
Degree: 2014, Université Catholique de Louvain
URL: http://hdl.handle.net/2078.1/142202
► The main aims of this thesis were (1) to develop new electrophysiological signal-processing methods to improve the signal-to-noise ratio of CSERPs and (2) to evaluate…
(more)
▼ The main aims of this thesis were (1) to develop new electrophysiological signal-processing methods to improve the signal-to-noise ratio of CSERPs and (2) to evaluate whether psychophysical and electrophysiological olfactory testing can be useful for the early diagnosis of AD. First, because of the poor signal-to-noise ratio of CSERPs, we developed new electrophysiological signal-processing methods to characterize the EEG responses elicited by chemosensory stimulation in humans, based on (1) spatio-temporal signal-denoising using an independent component analysis and (2) time-frequency analysis of non phase-locked EEG responses using a continuous wavelet transform. We then validated this technique in a group of healthy controls and evaluated its feasibility and clinical usefulness to assess olfactory function in patients suffering from smell disorders (postinfectious and posttraumatic). We then investigated whether psychophysical and electrophysiological olfactory testing can be useful for the early differential diagnosis of MCI. Olfactory dysfunction in AD patients has been widely investigated. However, as reported before, studies investigating olfaction in AD present several drawbacks, which we have attempted to overcome. First, in contrast with several studies, we did not only investigate odor identification performance but also odor detection threshold and odor discrimination, using the validated Sniffin’ Sticks test. Second, we aimed to improve our understanding of the relationship between olfaction and AD, and disentangle the contribution of pure perceptual impairment and semantic memory impairment. For this purpose, we developed a specific psychophysical test relying on picture-based olfactory identification test and a control picture-based auditory identification test. Third, data was acquired in homogenous and well-characterized populations. Only MCI patients with a positive Amyloid-β PET were included in the MCI group. This group was compared to an age-matched group of healthy controls. Both groups were characterized using detailed neuropsychological testing, Amyloid-β PET ([F18]-Flutemetamol PET), [F18]-FDG-PET, apolipoprotein E genotyping and volumetric brain MRI. Fourth, we performed a unirhinal psychophysical and electrophysiological assessment of olfactory function in order to evaluate if an asymmetry in olfactory function could be predictive of MCI. Another point that deserved to be raised was that olfactory dysfunction is frequent among the general population but only a minority of these patients will evolve towards AD. It is generally admitted that patients at risk for developing neurodegenerative disease are those with idiopathic olfactory loss. In contrast, it is assumed that patients suffering from postinfectious or posttraumatic olfactory loss do not have an increased risk of developing AD. Thus, we included patients suffering from postinfectious olfactory loss as a supplementary control group, in order to evaluate and compare the olfactory dysfunction observed in MCI and idiopathic olfactory…
Advisors/Committee Members: UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, UCL - Faculté de médecine et médecine dentaire, Olivier, Etienne, Hummel, Thomas, Schaal, Benoist, Jorissen, Mark, Ivanoiu, Adrian, Rossion, Bruno, Mouraux, André, Rombaux, Philippe.
Subjects/Keywords: Olfaction; Trigeminal; Chemosensory event-related potentials; Neurodegenerative; Alzheimer; Electroencephalography; Psychophysics; Cognition
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APA ·
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APA (6th Edition):
Huart, C. (2014). Novel psychophysical and electrophysiological tools to assess human olfactory function and evaluation of their potential for an early diagnosis of Alzheimer’s disease. (Thesis). Université Catholique de Louvain. Retrieved from http://hdl.handle.net/2078.1/142202
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Huart, Caroline. “Novel psychophysical and electrophysiological tools to assess human olfactory function and evaluation of their potential for an early diagnosis of Alzheimer’s disease.” 2014. Thesis, Université Catholique de Louvain. Accessed January 19, 2021.
http://hdl.handle.net/2078.1/142202.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Huart, Caroline. “Novel psychophysical and electrophysiological tools to assess human olfactory function and evaluation of their potential for an early diagnosis of Alzheimer’s disease.” 2014. Web. 19 Jan 2021.
Vancouver:
Huart C. Novel psychophysical and electrophysiological tools to assess human olfactory function and evaluation of their potential for an early diagnosis of Alzheimer’s disease. [Internet] [Thesis]. Université Catholique de Louvain; 2014. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/2078.1/142202.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Huart C. Novel psychophysical and electrophysiological tools to assess human olfactory function and evaluation of their potential for an early diagnosis of Alzheimer’s disease. [Thesis]. Université Catholique de Louvain; 2014. Available from: http://hdl.handle.net/2078.1/142202
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Toronto
19.
Chen, Qixiang David.
Neuroimaging of Trigeminal Neuralgia: Application of Population Diffusion Magnetic Resonance Tractography and Machine Learning.
Degree: PhD, 2018, University of Toronto
URL: http://hdl.handle.net/1807/91803
► Idiopathic (Classic) Trigeminal Neuralgia (TN) is a facial neuropathic pain syndrome characterized by paroxysmal, shock-like pain condition affecting one or more of the three trigeminal…
(more)
▼ Idiopathic (Classic)
Trigeminal Neuralgia (TN) is a facial neuropathic pain syndrome characterized by paroxysmal, shock-like pain condition affecting one or more of the three
trigeminal nerve (CNV) branches. TN is believed to be associated with nerve-vascular
compression in the CNV root-entry-zone, but its pathophysiology is still unclear. Singletensor diffusion tensor neuroimaging (DTI) studies of CNV revealed diffusivity changes in the cistern segment. However, the portion of the nerve within the brainstem remained elusive due to DTI limits. Diffusion imaging of TN is also error-prone due to manual data processing and analysis.
This thesis aims to: 1) develop a fully-automated software framework to analyze diffusion tractography to reduce error and increase speed of experiments. 2) to apply the method developed to the analysis of the
trigeminal system in a more substantial patient group, and apply state-of-the-art methods to advance the study of TN further. The specific aims are: a) establish the feasibility of multi-tensor tractography of brainstem CNV; b) establish the best way to minimize DWI to T1 co-registration error across multiple subjects; c) Create the software framework to generate and quantify tractography at the group level; d) apply the methodology to the reconstruction and quantification of the
trigeminal sensory pathway. Towards these goals, in Study I, we establish the feasibility of applying multi-tensor tractography to delineate the full course of CNV and demonstrate that TN is uniquely identified by disruptions in the cistern/REZ, while MS-TN by disruptions in the brainstem course of the nerve. In Study II, we determine that the best T1-DWI co-registration scalar is the Mean DWI image. In Study III, we present the Selective Automated Group Integrated Tractography (SAGIT) processing pipeline framework. Finally, in Study IV, we deploy end-to-end machine-learning TN classification to automatically discover diffusivity disruptions in the cistern/REZ CNV, the trigeminopontothalamic decussaion, and thalamocortico S1 pathway.
In sum, this thesis presents a detailed road-map of the development and application of end-to-end diffusion tractography machine learning classification. The application to TN revealed specific diffusivity changes in
trigeminal CN V, pontine, and S1 white matter pathways, and pin-points the locations of the diffusivity disruptions at millimetre level.
Advisors/Committee Members: Hodaie, Mojgan, Medical Science.
Subjects/Keywords: diffusion imaging; machine learning; neuroimaging; pain; tractography; trigeminal neuralgia; 0317
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APA (6th Edition):
Chen, Q. D. (2018). Neuroimaging of Trigeminal Neuralgia: Application of Population Diffusion Magnetic Resonance Tractography and Machine Learning. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/91803
Chicago Manual of Style (16th Edition):
Chen, Qixiang David. “Neuroimaging of Trigeminal Neuralgia: Application of Population Diffusion Magnetic Resonance Tractography and Machine Learning.” 2018. Doctoral Dissertation, University of Toronto. Accessed January 19, 2021.
http://hdl.handle.net/1807/91803.
MLA Handbook (7th Edition):
Chen, Qixiang David. “Neuroimaging of Trigeminal Neuralgia: Application of Population Diffusion Magnetic Resonance Tractography and Machine Learning.” 2018. Web. 19 Jan 2021.
Vancouver:
Chen QD. Neuroimaging of Trigeminal Neuralgia: Application of Population Diffusion Magnetic Resonance Tractography and Machine Learning. [Internet] [Doctoral dissertation]. University of Toronto; 2018. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/1807/91803.
Council of Science Editors:
Chen QD. Neuroimaging of Trigeminal Neuralgia: Application of Population Diffusion Magnetic Resonance Tractography and Machine Learning. [Doctoral Dissertation]. University of Toronto; 2018. Available from: http://hdl.handle.net/1807/91803
University of Iowa
20.
Kaiser, Eric Alan.
Effects of CGRP and light in mice: implications for photophobia and migraine.
Degree: PhD, Molecular Physiology and Biophysics, 2014, University of Iowa
URL: https://ir.uiowa.edu/etd/3114
► Calcitonin gene-related peptide (CGRP) has been strongly implicated in the pathophysiology of migraine. CGRP levels are elevated during a migraine attack. Injection of CGRP…
(more)
▼ Calcitonin gene-related peptide (CGRP) has been strongly implicated in the pathophysiology of migraine. CGRP levels are elevated during a migraine attack. Injection of CGRP can trigger a delayed migraine-like headache in migraineurs. Finally, CGRP receptor antagonists are effective antimigraine therapeutics. Consequently, a CGRP-sensitized mouse,
nestin/hRAMP1 was genetically engineered to conditionally express a subunit of the CGRP receptor, hRAMP1, in neurons and glia. In response to CGRP,
nestin/hRAMP1 mice demonstrated a significant decrease in time in the light zone of a dim light-dark box compared to vehicle-treated
nestin/hRAMP1 mice and CGRP-treated control mice. This reflects photophobia-like behavior. Photophobia is a common symptom of migraine, where light exacerbates the headache pain. Furthermore, CGRP decreased motility in the dark zone, which may reflect exacerbation of pain by movement that is often experienced during a migraine. Wildtype mice have also demonstrated this CGRP-induced behavior, but required bright light and habituation to the chamber. While there is a difference in sensitivity in this assay between wildtype and
nestin/hRAMP1 mice, it demonstrates that endogenous CGRP receptors are sufficient to convey this behavior. A common antimigraine drug, rizatriptan, attenuated the CGRP-induced behaviors in wildtype mice validating the assay as a migraine model. To explore the relative contributions of CGRP receptors on neurons versus glia,
synapsin/hRAMP1 transgenic mice were genetically engineered to express hRAMP1 in neurons only. In contrast to the
nestin/hRAMP1 mice, the
synapsin/hRAMP1 mice did not show CGRP-induced light aversion upon naïve exposure to a dim chamber. This suggests that neuronal overexpression of hRAMP1 is insufficient to convey a heighted sensitivity to CGRP in the light aversion assay. As a first step to understanding the mechanism underlying CGRP-induced light aversion, a non-behavioral assay was developed to measure photic blink reflexes by measuring orbicularis oculi EMG responses in mice. Bright light increased orbicularis oculi activity, and an air puff induced a blink response. Interestingly. CGRP and bright light increased the duration of squinting following the air puff-induced blink. This pilot suggests that the
trigeminal system plays a key role in mediating CGRP-induced light sensitivity. Overall, these studies propose a potential model for the mechanisms involved in migraine and photophobia in which CGRP likely acts through endogenous CGRP receptors on neurons and glia in the
trigeminal system to trigger light sensitivity.
Advisors/Committee Members: Russo, Andrew F. (supervisor).
Subjects/Keywords: Behavior; CGRP; Migraine; Mouse model; Photophobia; Trigeminal; Biophysics
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APA (6th Edition):
Kaiser, E. A. (2014). Effects of CGRP and light in mice: implications for photophobia and migraine. (Doctoral Dissertation). University of Iowa. Retrieved from https://ir.uiowa.edu/etd/3114
Chicago Manual of Style (16th Edition):
Kaiser, Eric Alan. “Effects of CGRP and light in mice: implications for photophobia and migraine.” 2014. Doctoral Dissertation, University of Iowa. Accessed January 19, 2021.
https://ir.uiowa.edu/etd/3114.
MLA Handbook (7th Edition):
Kaiser, Eric Alan. “Effects of CGRP and light in mice: implications for photophobia and migraine.” 2014. Web. 19 Jan 2021.
Vancouver:
Kaiser EA. Effects of CGRP and light in mice: implications for photophobia and migraine. [Internet] [Doctoral dissertation]. University of Iowa; 2014. [cited 2021 Jan 19].
Available from: https://ir.uiowa.edu/etd/3114.
Council of Science Editors:
Kaiser EA. Effects of CGRP and light in mice: implications for photophobia and migraine. [Doctoral Dissertation]. University of Iowa; 2014. Available from: https://ir.uiowa.edu/etd/3114
21.
Alper, Judy.
Ultrahigh Field Magnetic Resonance Imaging – Technical Development and Translational Applications.
Degree: MS(M.S.), Biomedical Engineering, 2016, City University of New York
URL: https://academicworks.cuny.edu/cc_etds_theses/636
► Magnetic resonance imaging (MRI) may be used to provide detailed images of the human body with excellent soft tissue contrast. Alongside its current widespread…
(more)
▼ Magnetic resonance imaging (MRI) may be used to provide detailed images of the human body with excellent soft tissue contrast. Alongside its current widespread clinical applications for diagnosis and treatment, MRI allows researchers to measure structure and function of different tissue types in order to advance our understanding of human biology and enable new medical applications of MRI. In particular, diseases affecting nerves and vessels, such as trigeminal neuralgia, with uncertain etiology can be studied using multiple MRI modalities so that treatment planning can we more effective and patient outcomes can be improved. Ultrahigh field MRI scanners, such as those operating at 7-‐tesla (7T), provide increased signal-‐to-‐noise ratio, which can be translated to higher spatial resolution. Additional advantages of high magnetic field MRI include enhanced vascular contrast as well as improved spectral separation and quantification for MR spectroscopy. These benefits over MRI at lower field strengths make ultrahigh field MRI a powerful new tool for performing quantitative image analysis with increased accuracy. One quantitative application of MRI is the detection and visualization of cells labeled with magnetic nanoparticles. This unconventional use of the imaging modality enables very effective imaging of cells or lesions tagged with these particles. The projects explored herein consist of such quantitative image analysis using advanced imaging techniques, including ultrahigh field MRI.
Subjects/Keywords: Magnetic resonance imaging (MRI); Trigeminal neuralgia; Nanoparticles; Biomedical Engineering and Bioengineering
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APA (6th Edition):
Alper, J. (2016). Ultrahigh Field Magnetic Resonance Imaging – Technical Development and Translational Applications. (Thesis). City University of New York. Retrieved from https://academicworks.cuny.edu/cc_etds_theses/636
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Alper, Judy. “Ultrahigh Field Magnetic Resonance Imaging – Technical Development and Translational Applications.” 2016. Thesis, City University of New York. Accessed January 19, 2021.
https://academicworks.cuny.edu/cc_etds_theses/636.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Alper, Judy. “Ultrahigh Field Magnetic Resonance Imaging – Technical Development and Translational Applications.” 2016. Web. 19 Jan 2021.
Vancouver:
Alper J. Ultrahigh Field Magnetic Resonance Imaging – Technical Development and Translational Applications. [Internet] [Thesis]. City University of New York; 2016. [cited 2021 Jan 19].
Available from: https://academicworks.cuny.edu/cc_etds_theses/636.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Alper J. Ultrahigh Field Magnetic Resonance Imaging – Technical Development and Translational Applications. [Thesis]. City University of New York; 2016. Available from: https://academicworks.cuny.edu/cc_etds_theses/636
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Southern California
22.
Wang, Yuanyuan.
Transient receptor potential A1 channel in nociceptive
sensation of weak acids and carbon dioxide and its
regulation.
Degree: PhD, Neuroscience, 2011, University of Southern California
URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/445135/rec/7587
► Pain sensation is critical to animal survival as it serves as an early warning system. Noxious stimuli are detected by the primary sensory neurons (nociceptors)…
(more)
▼ Pain sensation is critical to animal survival as it
serves as an early warning system. Noxious stimuli are detected by
the primary sensory neurons (nociceptors) whose cell bodies reside
in the
trigeminal and dorsal root ganglia. In order to better
understand the sensory transduction pathway, the primary step would
be to identify the specific molecular sensor for specific
pain-evoking stimuli and uncover its gating mechanism. One
nociceptive sensor is the transient receptor potential A1 (TRPA1)
channel, which is the principle detector for a variety of
environmental irritants and pungent compounds, such as mustard oil
and cinnamladehyde. Responses of TRPA1 to pungent compounds are
further regulated by extracellular Ca2+. However, the underlying
mechanism is not clearly understood. Here we identified a TRPA1
pore mutant that has greatly reduced Ca2+ permeability. By studying
the function of this mutant, we have discovered that the Ca2+
regulatory effect requires Ca2+ entry into the cell and the
resulting increase of its intracellular concentration.; High
concentrations of CO2, as in carbonated beverages, are known to
cause pungent or painful sensation which is thought to originate
with the activation of
trigeminal nociceptors that innervate the
nasal and oral cavity. The molecular targets remain however
obscure. Here we showed that TRPA1 is both necessary and sufficient
to mediate
trigeminal responses to CO2. CO2 causes both
extracellular and intracellular acidification and we identified the
proximate stimulus that gates TRPA1 in response to CO2 is
intracellular protons. Weak organic acids, such as acetic acid in
vinegar, are also irritation or pain-evoking stimuli and they can
acidify the cell cytosol. Similar to CO2, We demonstrated that the
molecular sensor for various weak acids in the
trigeminal system is
TRPA1, and it does so by sensing intracellular acidification. Our
findings suggest a role of TRPA1 as a potential therapeutic target
to relieve acidotic pain.
Advisors/Committee Members: Liman, Emily R. (Committee Chair), Arnold, Donald B. (Committee Member), McKemy, David D. (Committee Member), Farley, Robert A. (Committee Member).
Subjects/Keywords: TRPA1; trigeminal neurons; nociception; calcium; weak acids; carbon dioxide
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APA (6th Edition):
Wang, Y. (2011). Transient receptor potential A1 channel in nociceptive
sensation of weak acids and carbon dioxide and its
regulation. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/445135/rec/7587
Chicago Manual of Style (16th Edition):
Wang, Yuanyuan. “Transient receptor potential A1 channel in nociceptive
sensation of weak acids and carbon dioxide and its
regulation.” 2011. Doctoral Dissertation, University of Southern California. Accessed January 19, 2021.
http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/445135/rec/7587.
MLA Handbook (7th Edition):
Wang, Yuanyuan. “Transient receptor potential A1 channel in nociceptive
sensation of weak acids and carbon dioxide and its
regulation.” 2011. Web. 19 Jan 2021.
Vancouver:
Wang Y. Transient receptor potential A1 channel in nociceptive
sensation of weak acids and carbon dioxide and its
regulation. [Internet] [Doctoral dissertation]. University of Southern California; 2011. [cited 2021 Jan 19].
Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/445135/rec/7587.
Council of Science Editors:
Wang Y. Transient receptor potential A1 channel in nociceptive
sensation of weak acids and carbon dioxide and its
regulation. [Doctoral Dissertation]. University of Southern California; 2011. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/445135/rec/7587
23.
Cornelison, Lauren Elise.
Calcitonin Gene-Related Peptide Promotes Peripheral and Central Trigeminal Sensitization.
Degree: MSin Biology, Biology, 2015, Missouri State University
URL: https://bearworks.missouristate.edu/theses/971
► Temporomandibular joint disorder is characterized by peripheral and central sensitization of trigeminal nociceptive neurons. Although CGRP is implicated in the development of central sensitization…
(more)
▼ Temporomandibular joint disorder is characterized by peripheral and central sensitization of
trigeminal nociceptive neurons. Although CGRP is implicated in the development of central sensitization by stimulating glial activation via its receptor, the mechanism by which CGRP promotes and maintains sensitization of
trigeminal nociceptive neurons is not well understood. The goal of my study was to investigate the role of calcitonin gene-related peptide (CGRP) on the initiation and maintenance of a nocifensive withdrawal response to mechanical stimulation following activation of primary
trigeminal sensory neurons. For my studies, I used adult male Sprague Dawley rats that were injected with CGRP alone or co-injected with inhibitors and determined changes in nocifensive behavior and inflammatory proteins. Intrathecal injection of CGRP increased nocifensive responses to mechanical stimulation up to 48 hours and this stimulatory effect was blocked by the antagonist peptide CGRP8-37 and a protein kinase A inhibitor. Results from my cellular studies provide evidence that elevated levels of CGRP in the spinal cord can promote bidirectional signaling within the
trigeminal system, a novel finding that helps to explain how central sensitization can lower the activation threshold of primary nociceptors in TMD patients.
Advisors/Committee Members: Paul Durham.
Subjects/Keywords: TMJ; calcitonin gene-related peptide; trigeminal ganglion; nociception; neuronal sensitization; Biology
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APA (6th Edition):
Cornelison, L. E. (2015). Calcitonin Gene-Related Peptide Promotes Peripheral and Central Trigeminal Sensitization. (Masters Thesis). Missouri State University. Retrieved from https://bearworks.missouristate.edu/theses/971
Chicago Manual of Style (16th Edition):
Cornelison, Lauren Elise. “Calcitonin Gene-Related Peptide Promotes Peripheral and Central Trigeminal Sensitization.” 2015. Masters Thesis, Missouri State University. Accessed January 19, 2021.
https://bearworks.missouristate.edu/theses/971.
MLA Handbook (7th Edition):
Cornelison, Lauren Elise. “Calcitonin Gene-Related Peptide Promotes Peripheral and Central Trigeminal Sensitization.” 2015. Web. 19 Jan 2021.
Vancouver:
Cornelison LE. Calcitonin Gene-Related Peptide Promotes Peripheral and Central Trigeminal Sensitization. [Internet] [Masters thesis]. Missouri State University; 2015. [cited 2021 Jan 19].
Available from: https://bearworks.missouristate.edu/theses/971.
Council of Science Editors:
Cornelison LE. Calcitonin Gene-Related Peptide Promotes Peripheral and Central Trigeminal Sensitization. [Masters Thesis]. Missouri State University; 2015. Available from: https://bearworks.missouristate.edu/theses/971
The Ohio State University
24.
Hamos, James E.
The synaptic organization of the motor nucleus of the
trigeminal nerve in the opossum.
Degree: PhD, Graduate School, 1979, The Ohio State University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1487085168785666
Subjects/Keywords: Biology; Opossums; Trigeminal nerve; Synapses
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APA (6th Edition):
Hamos, J. E. (1979). The synaptic organization of the motor nucleus of the
trigeminal nerve in the opossum. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1487085168785666
Chicago Manual of Style (16th Edition):
Hamos, James E. “The synaptic organization of the motor nucleus of the
trigeminal nerve in the opossum.” 1979. Doctoral Dissertation, The Ohio State University. Accessed January 19, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=osu1487085168785666.
MLA Handbook (7th Edition):
Hamos, James E. “The synaptic organization of the motor nucleus of the
trigeminal nerve in the opossum.” 1979. Web. 19 Jan 2021.
Vancouver:
Hamos JE. The synaptic organization of the motor nucleus of the
trigeminal nerve in the opossum. [Internet] [Doctoral dissertation]. The Ohio State University; 1979. [cited 2021 Jan 19].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1487085168785666.
Council of Science Editors:
Hamos JE. The synaptic organization of the motor nucleus of the
trigeminal nerve in the opossum. [Doctoral Dissertation]. The Ohio State University; 1979. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1487085168785666
Arizona State University
25.
Orthlieb, Gerrit Chi Luk.
Effects of Trigeminal Nerve Stimulation on the ANS and
Proprioception: High Frequency TNS Reduces Proprioceptive End-point
Error.
Degree: Biomedical Engineering, 2019, Arizona State University
URL: http://repository.asu.edu/items/54944
► Previously accomplished research examined sensory integration between upper limb proprioception and tactile sensation. The active proprioceptive-tactile relationship points towards an opportunity to examine neuromodulation effects…
(more)
▼ Previously accomplished research examined sensory
integration between upper limb proprioception and tactile
sensation. The active proprioceptive-tactile relationship points
towards an opportunity to examine neuromodulation effects on
sensory integration with respect to proprioceptive error magnitude
and direction. Efforts to improve focus and attention during upper
limb proprioceptive tasks results in a decrease of proprioceptive
error magnitudes and greater endpoint accuracy. Increased focus and
attention can also be correlated to neurophysiological activity in
the Locus Coeruleus (LC) during a variety of mental tasks. Through
non-invasive trigeminal nerve stimulation, it may be possible to
affect the activity of the LC and induce improvements in arousal
and attention that would assist in proprioceptive estimation. The
trigeminal nerve projects to the LC through the mesencephalic
nucleus of the trigeminal complex, providing a pathway similar to
the effects seen from vagus nerve stimulation. In this experiment,
the effect of trigeminal nerve stimulation (TNS) on proprioceptive
ability is evaluated by the proprioceptive estimation error
magnitude and direction, while LC activation via autonomic pathways
is indirectly measured using pupil diameter, pupil recovery time,
and pupil velocity. TNS decreases proprioceptive error magnitude in
59% of subjects, while having no measurable impact on
proprioceptive strategy. Autonomic nervous system changes were
observed in 88% of subjects, with mostly parasympathetic activation
and a mixed sympathetic effect.
Subjects/Keywords: Biomedical engineering; Neurosciences; Physiology; Autonomic; Neuromodulation; Proprioception; Pupil; Stimulation; Trigeminal
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APA (6th Edition):
Orthlieb, G. C. L. (2019). Effects of Trigeminal Nerve Stimulation on the ANS and
Proprioception: High Frequency TNS Reduces Proprioceptive End-point
Error. (Masters Thesis). Arizona State University. Retrieved from http://repository.asu.edu/items/54944
Chicago Manual of Style (16th Edition):
Orthlieb, Gerrit Chi Luk. “Effects of Trigeminal Nerve Stimulation on the ANS and
Proprioception: High Frequency TNS Reduces Proprioceptive End-point
Error.” 2019. Masters Thesis, Arizona State University. Accessed January 19, 2021.
http://repository.asu.edu/items/54944.
MLA Handbook (7th Edition):
Orthlieb, Gerrit Chi Luk. “Effects of Trigeminal Nerve Stimulation on the ANS and
Proprioception: High Frequency TNS Reduces Proprioceptive End-point
Error.” 2019. Web. 19 Jan 2021.
Vancouver:
Orthlieb GCL. Effects of Trigeminal Nerve Stimulation on the ANS and
Proprioception: High Frequency TNS Reduces Proprioceptive End-point
Error. [Internet] [Masters thesis]. Arizona State University; 2019. [cited 2021 Jan 19].
Available from: http://repository.asu.edu/items/54944.
Council of Science Editors:
Orthlieb GCL. Effects of Trigeminal Nerve Stimulation on the ANS and
Proprioception: High Frequency TNS Reduces Proprioceptive End-point
Error. [Masters Thesis]. Arizona State University; 2019. Available from: http://repository.asu.edu/items/54944
26.
Mascaro, Marcelo Betti.
Conexões e caracterização neuroquímica de vias neurais envolvidas com o controle dos movimentos mandibulares.
Degree: PhD, Ciências Morfofuncionais, 2007, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/42/42131/tde-16102007-134818/
;
► O núcleo motor do trigêmeo (Mo5) está cercado por um anel de neurônios pré-motores localizados na região h. Estudos demonstram que neurônios que inervam o…
(more)
▼ O núcleo motor do trigêmeo (Mo5) está cercado por um anel de neurônios pré-motores localizados na região h. Estudos demonstram que neurônios que inervam o Mo5 estão distribuídos no tronco encefálico e no prosencéfalo. Após implante de traçador retrógrado no Mo5, verificamos células retrogradamente marcadas no núcleo mesencefálico do trigêmeo (Me5), na região h e em núcleos prosencefálicos como o central da amígdala (CeA), a área hipotalâmica lateral (LH) e o parasubtalâmico (PSTh). Para confirmação, realizamos injeção de traçador anterógrado e investigamos, também, a neuroquímica das projeções. Neurônios do CeA que se projetam para o Mo5 recebem inervação de fibras imunorreativas ao fator liberador de corticotrofina (CFR-ir) e/ou à tirosina hidroxilase (TH-ir); alguns neurônios da LH que se projetam para o Mo5 são imunorreativos à orexina (ORX) e alguns neurônios do PSTh que se projetam para o Mo5 são innervados por fibras TH-ir. O Me5 recebe grande inervação do CeA e moderada da LH e do PSTh, possuindo grande aferência de fibras imunorreativas ao CRF, ORX e TH
The trigeminal motor nucleus (Mo5) is surrounded by a ring of premotor neurons defined as the h region. Studies have shown that neurons innervating the Mo5 are located in brainstem and in forebrain nuclei. Through the injection of the retrograde tracer cholera toxin b subunit/CTb in the Mo5, we found retrograde labeled neurons in the brainstem including the h region and the mesencephalic trigeminal nucleus (Me5), and in forebrain nuclei such as the central nucleus of amygdala (CeA), the lateral hypothalamic area (LH) and the parasubthalamic nucleus (PSTh). As control, we injected the anterograde tracer biotin dextran amine and found that these areas project direct or indirectly via the h region or the Me5 to the Mo5. Some CeA neurons that project to the Mo5 receive corticotrophin releasing factor (CRF) and tyrosine hydroxylase (TH) innervation, some LH neurons that project to Mo5 express orexin, and PSTh neurons that project to the Mo5 receive TH innervation. The Me5 is also innervated by CeA, LH and PSTh neurons and by CRF, orexin and TH immunoreactive fibers
Advisors/Committee Members: Elias, Carol Fuzeti.
Subjects/Keywords: Bruxism; Bruxismo; CRF; Fator liberador de corticotrofina; Mesencephalic trigeminal nucleus; Motor trigeminal nucleus; Núcleo mesencefálico do trigêmeo; Núcleo motor do trigêmeo; Orexin; Orexina; Tirosina hidroxilase; Tyrosine hydroxylase
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APA (6th Edition):
Mascaro, M. B. (2007). Conexões e caracterização neuroquímica de vias neurais envolvidas com o controle dos movimentos mandibulares. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/42/42131/tde-16102007-134818/ ;
Chicago Manual of Style (16th Edition):
Mascaro, Marcelo Betti. “Conexões e caracterização neuroquímica de vias neurais envolvidas com o controle dos movimentos mandibulares.” 2007. Doctoral Dissertation, University of São Paulo. Accessed January 19, 2021.
http://www.teses.usp.br/teses/disponiveis/42/42131/tde-16102007-134818/ ;.
MLA Handbook (7th Edition):
Mascaro, Marcelo Betti. “Conexões e caracterização neuroquímica de vias neurais envolvidas com o controle dos movimentos mandibulares.” 2007. Web. 19 Jan 2021.
Vancouver:
Mascaro MB. Conexões e caracterização neuroquímica de vias neurais envolvidas com o controle dos movimentos mandibulares. [Internet] [Doctoral dissertation]. University of São Paulo; 2007. [cited 2021 Jan 19].
Available from: http://www.teses.usp.br/teses/disponiveis/42/42131/tde-16102007-134818/ ;.
Council of Science Editors:
Mascaro MB. Conexões e caracterização neuroquímica de vias neurais envolvidas com o controle dos movimentos mandibulares. [Doctoral Dissertation]. University of São Paulo; 2007. Available from: http://www.teses.usp.br/teses/disponiveis/42/42131/tde-16102007-134818/ ;
27.
井川, 加織.
Distribution of hemokinin-1 in the rat trigeminal ganglion and trigeminal sensory nuclear complex.
Degree: 博士(医学), 2017, University of Miyazaki / 宮崎大学
URL: http://hdl.handle.net/10458/6028
以下に掲載:Archives of Oral Biology .2017,Volume 79.pages 62-69
Subjects/Keywords: hemokinin-1; immunohistochemistry; trigeminal sensory nuclear complex; trigeminal ganglion; pruritus; substance P
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APA (6th Edition):
井川, . (2017). Distribution of hemokinin-1 in the rat trigeminal ganglion and trigeminal sensory nuclear complex. (Thesis). University of Miyazaki / 宮崎大学. Retrieved from http://hdl.handle.net/10458/6028
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
井川, 加織. “Distribution of hemokinin-1 in the rat trigeminal ganglion and trigeminal sensory nuclear complex.” 2017. Thesis, University of Miyazaki / 宮崎大学. Accessed January 19, 2021.
http://hdl.handle.net/10458/6028.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
井川, 加織. “Distribution of hemokinin-1 in the rat trigeminal ganglion and trigeminal sensory nuclear complex.” 2017. Web. 19 Jan 2021.
Vancouver:
井川 . Distribution of hemokinin-1 in the rat trigeminal ganglion and trigeminal sensory nuclear complex. [Internet] [Thesis]. University of Miyazaki / 宮崎大学; 2017. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/10458/6028.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
井川 . Distribution of hemokinin-1 in the rat trigeminal ganglion and trigeminal sensory nuclear complex. [Thesis]. University of Miyazaki / 宮崎大学; 2017. Available from: http://hdl.handle.net/10458/6028
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
28.
Foguem, Clovis.
L’olfaction chez le patient gériatrique : constantes et spécificités pathologiques des interactions olfacto-trigéminales dans une population porteuse de synucléopathies : Olfaction in elderly : constants and pathological characteristics of the olfactory and trigeminal interactions in a population carrying synucleopathies.
Degree: Docteur es, Neurosciences, 2017, Bourgogne Franche-Comté
URL: http://www.theses.fr/2017UBFCI015
► CONTEXTE: La maladie de Parkinson idiopathique (MPI), la démence à corps de Lewy (DCL) et la démence parkinsonienne (DP) sont des synucléinopathies. La dysfonction olfactive…
(more)
▼ CONTEXTE: La maladie de Parkinson idiopathique (MPI), la démence à corps de Lewy (DCL) et la démence parkinsonienne (DP) sont des synucléinopathies. La dysfonction olfactive est reconnue comme étant une caractéristique principale de ces maladies. L'objectif de ce travail était d'évaluer et de comparer les seuils de détection olfactifs dans ces trois synucléinopathies (MPI, DP, DCL) chez des sujets âgés de plus de 65ans. Dans cette optique, trois études ont été menées utilisant des substances odorantes stimulant variablement les systèmes trigéminal et olfactif.MÉTHODES: les tests de détection des seuils olfactifs ont été réalisés chez (1) 89 patients ayant une MPI versus témoins sains, (2) 17 PD versus MPI et (3) 20 DCL versus PD versus témoins sains appariés, en utilisant l'alcool phényléthylique, le n-butanol et la pyridine comme stimuli. Les seuils de détection de ces 3 odorants ont été évalués à l'aide d'une série de dilution de facteur 2 et une procédure ascendante de choix forcé.Les données ont été analysées en utilisant des tests de Mann-Whitney-Wilcoxon ou Kruskal-Wallis, la corrélation de Spearman et des analyses de covariance. Des analyses discriminantes ont également été réalisées.RÉSULTATS: (1) Les seuils de détection olfactifs sont capables de discriminer les patients MPI des témoins sains et les patients ayant une MPI bénigne de ceux avec autonomie déficiente. De plus, nous avons trouvé une subtile interaction entre les systèmes olfacto-trigeminal.(2) Nos résultats mettent en évidence, une absence de différence significative des seuils de détection des odorants entre MPI et PD appariés.(3) Nous avons constaté des différences significatives des seuils olfactifs entre patients ayant une DCL, une DP et témoins sains (p <0,001), avec une altération majeure de la sensibilité olfactive chez les patients atteints de DCL par rapport à ceux ayant une DP.Au travers des 3 études, une corrélation significative a été trouvée entre les seuils de détection des trois odorants.CONCLUSION: Ce travail souligne que la DCL peut être distinguée de la DP, la DP des sujets sains et la MPI des sujets sains en évaluant les seuils de détection des trois odorants. Cependant, l’absence de différence significative entre les seuils de détection olfactifs entre les MPI et DP soulève des doutes sur l'importance des tests de seuils de détection olfactive dans le suivi cognitif dans la MPI. D'autres recherches sur le dysfonctionnement olfactif dans les synucléinopathies sont nécessaires pour conforter nos résultats.MOTS CLÉS: Principales synucléinopathies (maladie Parkinson idiopathique, Démence parkinsonienne, Démence à corps de Lewy); seuils de détection des odorants; interactions des systèmes olfacto-trigéminal ; diagnostics positif et différentiel.
Idiopathic Parkinson disease (IPD), Dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD) are synucleinopathies. Olfactory impairment is recognized as a characteristic feature of some synucleinopathies. The aim of this study was to assess and compare olfactory detection…
Advisors/Committee Members: Schaal, Benoist (thesis director).
Subjects/Keywords: Olfaction; Peronnes âgées; Interactions olfacto-Trigéminales; Synucléinopathies; Trijumeau; Maladie de Parkinson; Olfaction; Elderly; Olfactory and trigeminal interactions; Synucleopathies; Trigeminal system; Parkinson disease; 616.8
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APA (6th Edition):
Foguem, C. (2017). L’olfaction chez le patient gériatrique : constantes et spécificités pathologiques des interactions olfacto-trigéminales dans une population porteuse de synucléopathies : Olfaction in elderly : constants and pathological characteristics of the olfactory and trigeminal interactions in a population carrying synucleopathies. (Doctoral Dissertation). Bourgogne Franche-Comté. Retrieved from http://www.theses.fr/2017UBFCI015
Chicago Manual of Style (16th Edition):
Foguem, Clovis. “L’olfaction chez le patient gériatrique : constantes et spécificités pathologiques des interactions olfacto-trigéminales dans une population porteuse de synucléopathies : Olfaction in elderly : constants and pathological characteristics of the olfactory and trigeminal interactions in a population carrying synucleopathies.” 2017. Doctoral Dissertation, Bourgogne Franche-Comté. Accessed January 19, 2021.
http://www.theses.fr/2017UBFCI015.
MLA Handbook (7th Edition):
Foguem, Clovis. “L’olfaction chez le patient gériatrique : constantes et spécificités pathologiques des interactions olfacto-trigéminales dans une population porteuse de synucléopathies : Olfaction in elderly : constants and pathological characteristics of the olfactory and trigeminal interactions in a population carrying synucleopathies.” 2017. Web. 19 Jan 2021.
Vancouver:
Foguem C. L’olfaction chez le patient gériatrique : constantes et spécificités pathologiques des interactions olfacto-trigéminales dans une population porteuse de synucléopathies : Olfaction in elderly : constants and pathological characteristics of the olfactory and trigeminal interactions in a population carrying synucleopathies. [Internet] [Doctoral dissertation]. Bourgogne Franche-Comté; 2017. [cited 2021 Jan 19].
Available from: http://www.theses.fr/2017UBFCI015.
Council of Science Editors:
Foguem C. L’olfaction chez le patient gériatrique : constantes et spécificités pathologiques des interactions olfacto-trigéminales dans une population porteuse de synucléopathies : Olfaction in elderly : constants and pathological characteristics of the olfactory and trigeminal interactions in a population carrying synucleopathies. [Doctoral Dissertation]. Bourgogne Franche-Comté; 2017. Available from: http://www.theses.fr/2017UBFCI015
University of Michigan
29.
Al-Hadlaq, Solaiman Mohammad.
Neurotrophins and functional differentiation of the geniculate and trigeminal ganglia.
Degree: PhD, Neurosciences, 2002, University of Michigan
URL: http://hdl.handle.net/2027.42/123116
► Neurotrophins are essential for the development of sensory neurons. The trigeminal ganglion provides most of the orofacial somatosensory innervation (touch, pain, and temperature) while the…
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▼ Neurotrophins are essential for the development of sensory neurons. The
trigeminal ganglion provides most of the orofacial somatosensory innervation (touch, pain, and temperature) while the geniculate ganglion is a major source of innervation to mammalian taste organs, the taste buds, including those in the soft palate and in fungiform papillae on the anterior two thirds of the tongue. Neurites from these two ganglia join outside of the skull and course together to innervate adjacent but distinct regions of taste papillae on the anterior tongue. In and around the papilla, neurotrophins are expressed in a distinct spatial pattern with brain-derived neurotrophic factor (BDNF) mRNA located in the area of future taste bud development, while neurotrophin 3 (NT3) mRNA is located in adjacent non-taste epithelium and in the papilla core. Geniculate neurons will innervate the BDNF-containing area where taste buds will develop, while
trigeminal neurons will innervate the NT3-containing non-taste epithelium of the papillae. This unique arrangement, where neurons from two anatomically distinct ganglia innervate adjacent but distinct targets with different neurotrophin expression patterns, provides a model to study the effects of neurotrophins on developmental biology of sensory neurons. To study the role of neurotrophins in development of geniculate and
trigeminal neurons, ganglia were explanted from embryonic rats and maintained in culture with added BDNF, neurotrophin 4 (NT4), nerve growth factor (NGF), or NT3. Survival (cell counts), morphological (density of neurite outgrowth), and functional (electrophysiological properties) differentiation of neurons were evaluated at two embryonically distinct stages, before and after papilla innervation. Results indicate that geniculate ganglion neurons have highly neurotrophin-specific survival, morphological, and functional characteristics, so that neurons supported under different neurotrophin conditions are very different from each other. On the other hand,
trigeminal neurons have similar neurite outgrowth density under different neurotrophins, suggesting a less specific response to neurotrophins that perhaps reflects the more heterogeneous neuronal population compared to the geniculate ganglion. The results indicate that geniculate neurons have neurotrophin-specific responses at early embryonic stages and suggest that neurotrophins encountered by geniculate neurons in and on their way to target organs can play a vital role in determining survival, morphological, and functional differentiation. In turn, differentiation of these properties will be essential to the formation of a properly functioning taste system.
Advisors/Committee Members: Mistretta, Charlotte M. (advisor).
Subjects/Keywords: Functional Differentiation; Geniculate; Neurotrophins; Trigeminal Ganglia
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APA ·
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APA (6th Edition):
Al-Hadlaq, S. M. (2002). Neurotrophins and functional differentiation of the geniculate and trigeminal ganglia. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/123116
Chicago Manual of Style (16th Edition):
Al-Hadlaq, Solaiman Mohammad. “Neurotrophins and functional differentiation of the geniculate and trigeminal ganglia.” 2002. Doctoral Dissertation, University of Michigan. Accessed January 19, 2021.
http://hdl.handle.net/2027.42/123116.
MLA Handbook (7th Edition):
Al-Hadlaq, Solaiman Mohammad. “Neurotrophins and functional differentiation of the geniculate and trigeminal ganglia.” 2002. Web. 19 Jan 2021.
Vancouver:
Al-Hadlaq SM. Neurotrophins and functional differentiation of the geniculate and trigeminal ganglia. [Internet] [Doctoral dissertation]. University of Michigan; 2002. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/2027.42/123116.
Council of Science Editors:
Al-Hadlaq SM. Neurotrophins and functional differentiation of the geniculate and trigeminal ganglia. [Doctoral Dissertation]. University of Michigan; 2002. Available from: http://hdl.handle.net/2027.42/123116
Penn State University
30.
Parkar, Anjum.
Perturbation of rapid eye movement (REM) sleep for seizure control in rodent model of temporal
lobe epilepsy
.
Degree: 2015, Penn State University
URL: https://submit-etda.libraries.psu.edu/catalog/26433
► Seizures are detrimental to the quality of life. Approximately, 1-2% of the US population suff�ers from epileptic disorders characterized by spontaneous recurrent seizures. Of these,…
(more)
▼ Seizures are detrimental to the quality of life. Approximately, 1-2% of the US population suff�ers from epileptic disorders characterized by spontaneous recurrent seizures. Of these, 25% are uncontrolled by pharmacological treatments. For such patients, alternative therapeutic approaches rely on using stimulation of certain brain regions that can assist in seizure control. Currently used open loop stimulation techniques, such as vagal nerve stimulation (VNS) and deep brain stimulation (DBS) have been tested in rodents and humans with some success. Continuous stimulation at regular intervals, such as VNS and DBS can lead to cognitive impairment, brain tissue damage as well as seizure induced epileptogenesis. Hence predicting and preventing seizures seems to be a more favorable approach. Decades of studies have shown that sleep or state of vigilance (SOV) can have an e�ffect on seizures. It has been demonstrated that there is a strong correlation between rapid eye movement (REM) sleep and seizure occurrence. It's also been shown that be-
sides REM state, theta (4-8Hz) associated with Wake state is also epileptic. We use the chronic tetanus toxin (TeTx) rodent model of Temporal Lobe Epilepsy (TLE) to investigate if REM state can be perturbed through sensory stimulation of the
Trigeminal Ganglion to control seizures. Our results indicate that REM state can be perturbed to control seizures. Fraction of seizures emerging out of stimulated REM state are far lower than REMs that were not stimulated. Since REM state
was perturbed and not interrupted, we led to the conclusion that some other dynamic that co-occurs with REM state, makes REM state seizure permissive. Our results also indicated that upon stimulation of the animal during Wake state, when
high theta is present, the fraction of seizures emerging from stimulated wake state
are also lower compared to un-stimulated Wake state. Hence, stimulation of Wake state during high theta, can also assist in seizure control. Taking these fi�ndings together, from a clinical standpoint, this novel approach of closed-loop stimulation
based on SOV detection, can be used to design neuro-modulatory systems to help design better treatment approaches for patients refractory to AEDs for seizure control.
Advisors/Committee Members: Bruce Gluckman, Dissertation Advisor/Co-Advisor, Bruce Gluckman, Committee Chair/Co-Chair, Steven Schiff, Committee Member, Thomas Neuberger, Committee Member, Kevin Douglas Alloway, Committee Member.
Subjects/Keywords: seizure control; seizure prediction; epilepsy; closed loop stimulation; sleep/wake behaviour; trigeminal nerve stimulation
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APA ·
Chicago ·
MLA ·
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CSE |
Export
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Manager
APA (6th Edition):
Parkar, A. (2015). Perturbation of rapid eye movement (REM) sleep for seizure control in rodent model of temporal
lobe epilepsy
. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/26433
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Parkar, Anjum. “Perturbation of rapid eye movement (REM) sleep for seizure control in rodent model of temporal
lobe epilepsy
.” 2015. Thesis, Penn State University. Accessed January 19, 2021.
https://submit-etda.libraries.psu.edu/catalog/26433.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Parkar, Anjum. “Perturbation of rapid eye movement (REM) sleep for seizure control in rodent model of temporal
lobe epilepsy
.” 2015. Web. 19 Jan 2021.
Vancouver:
Parkar A. Perturbation of rapid eye movement (REM) sleep for seizure control in rodent model of temporal
lobe epilepsy
. [Internet] [Thesis]. Penn State University; 2015. [cited 2021 Jan 19].
Available from: https://submit-etda.libraries.psu.edu/catalog/26433.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Parkar A. Perturbation of rapid eye movement (REM) sleep for seizure control in rodent model of temporal
lobe epilepsy
. [Thesis]. Penn State University; 2015. Available from: https://submit-etda.libraries.psu.edu/catalog/26433
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
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Open Access Theses and Dissertations
