subject:(transdermal fentanyl)

1. Svensson, Rebecka. Smärtlindring med opioider. En jämförelse mellan olika beredningsformer av fentanyl och morfin.

Degree: Chemistry and Biomedical Sciences, 2017, Linnaeus University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-67290

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Smärta definieras enligt IASP (International Association of the Study of Pain) som ”An unpleasant sensory and emotional experience associated with actual or potential tissue… (more)

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Smärta definieras enligt IASP (International Association of the Study of Pain) som ”An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage”, vilket betyder att en potentiell eller faktisk vävnadsskada kan orsaka en känslomässig eller sensorisk obehaglig upplevelse. Smärtupplevelsen hos individer varierar och är därmed personlig. För behandling av smärta finns flertalet olika alternativa läkemedel, däribland ingår opioider. Till kategorin opioider hör bland annat morfin och fentanyl. Bortsett från den smärtlindrande effekten som morfin respektive fentanyl genererar, kan negativa biverkningar även uppstå. Biverkningar kan, som för andra opioider, involvera eufori, illamående, kräkningar, klåda, förstoppning och sedering till mer allvarliga biverkningar som respiratorisk depression. Det finns olika behandlingsalternativ med dessa preparat, däribland oral och intravenös administrering av morfin. Fentanyl kan bland annat administreras buckalt, nebuliserat, intranasalt och transdermalt. Fentanyl är 100 gånger mer potent än morfin och därmed är transdermal behandling möjlig. Syftet med detta litteraturarbete var att kontrollera hur fentanyl jämför sig i olika beredningsformer med morfins effekt på smärta, samt att se vilka förgiftningsproblem som finns med fentanyl. För att hitta relevanta studier som behandlade detta område gjordes sökningar via databasen PubMed. De flesta granskade studier i arbetet tyder på att fentanyl i olika beredningsformer fungerar bra som ett alternativ vid antingen oral eller intravenös behandling med morfin, vid smärta. Fentanyl ses även som ett säkert och effektivt alternativ för behandling av smärta. Det är inte särskilt vanligt att barn drabbas av förgiftning som är orsakade av läkemedel, men fall förekommer. Opioider är en av de läkemedel som orsakar flest dödsfall relaterat till förgiftning hos barn under 5 år. Förgiftning som orsakats av fentanyl kan effektivt behandlas med antagonisten naloxon. Typiska symtom vid förgiftning av fentanyl var enligt litteraturarbetets fallrapporter kontraherade pupiller (1mm), kräkningar, illamående, respiratorisk acidos och hög hjärtfrekvens. Deltagarantalet i de flesta studier var ganska låga, och för att litteraturstudiens frågeställning ska besvaras med säkerhet bör mer forskning genomföras inom området.

According to IASP (International Association of the Study of Pain), pain is defined as “An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage”. The pain experience is individual and is therefore personal. For the treatment of pain, there are several different drug alternatives, including opioids. Fentanyl and morphine belong to the category “opioids”. Apart from the analgesic effect, morphine and fentanyl can also cause adverse side effects. Side effects, like for other opioids, can be euphoria, nausea, vomiting, itching, constipation and sedation but also more serious side effects…

Subjects/Keywords: Buckal; Fentanyl; Intranasal; Intravenös; Morfin; Nebuliserad; Oral; Smärta; Toxicitet; Transdermal.; Medical and Health Sciences; Medicin och hälsovetenskap

…smärtlindring behandlades kvinnan med transdermal fentanyl (Durogesic 100 µg/timmen) och mot… …transdermal fentanyl versus morphine” med samma avgränsningar som ovanstående sökning hade. Denna… …och enkelheten mellan transdermal fentanyl (ITS) och intravenös (IV)… …eller transdermal fentanyl. Under de första tre timmarna kunde patienterna få ytterligare… …syntetiska opioider, där fentanyl bland annat ingår (4). 2 Verkningsmekanism Det finns…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Svensson, R. (2017). Smärtlindring med opioider. En jämförelse mellan olika beredningsformer av fentanyl och morfin. (Thesis). Linnaeus University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-67290

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Svensson, Rebecka. “Smärtlindring med opioider. En jämförelse mellan olika beredningsformer av fentanyl och morfin.” 2017. Thesis, Linnaeus University. Accessed January 23, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-67290.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Svensson, Rebecka. “Smärtlindring med opioider. En jämförelse mellan olika beredningsformer av fentanyl och morfin.” 2017. Web. 23 Jan 2021.

Vancouver:

Svensson R. Smärtlindring med opioider. En jämförelse mellan olika beredningsformer av fentanyl och morfin. [Internet] [Thesis]. Linnaeus University; 2017. [cited 2021 Jan 23]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-67290.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Svensson R. Smärtlindring med opioider. En jämförelse mellan olika beredningsformer av fentanyl och morfin. [Thesis]. Linnaeus University; 2017. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-67290

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Ρέλλια, Παναγιώτα. Αξιολόγηση του διαδερμικού συστήματος φεντανύλης στη μετεγχειρητική αναλγησία ασθενών με κακοήθεια.

Degree: 2000, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/20365

Subjects/Keywords: Αναλγητικά; Οπιοειδή; Φεντανύλη; Αναισθητική τεχνική; Διαδερμική χορήγηση; Φαρμακοκινητική; Συστηματική απορρόφηση; Επιπλοκές; Analgesics; Opioids; Fentanyl; Anaesthetic techniques; Transdermal delivery; Pharmacokinetics; Systemic absorption; Complications

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ρέλλια, . �. (2000). Αξιολόγηση του διαδερμικού συστήματος φεντανύλης στη μετεγχειρητική αναλγησία ασθενών με κακοήθεια. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/20365

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ρέλλια, Παναγιώτα. “Αξιολόγηση του διαδερμικού συστήματος φεντανύλης στη μετεγχειρητική αναλγησία ασθενών με κακοήθεια.” 2000. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed January 23, 2021. http://hdl.handle.net/10442/hedi/20365.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ρέλλια, Παναγιώτα. “Αξιολόγηση του διαδερμικού συστήματος φεντανύλης στη μετεγχειρητική αναλγησία ασθενών με κακοήθεια.” 2000. Web. 23 Jan 2021.

Vancouver:

Ρέλλια �. Αξιολόγηση του διαδερμικού συστήματος φεντανύλης στη μετεγχειρητική αναλγησία ασθενών με κακοήθεια. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2000. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10442/hedi/20365.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ρέλλια �. Αξιολόγηση του διαδερμικού συστήματος φεντανύλης στη μετεγχειρητική αναλγησία ασθενών με κακοήθεια. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2000. Available from: http://hdl.handle.net/10442/hedi/20365

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Swedish University of Agricultural Sciences

3. Malavasi, Laís de Matos. Physiological and behavioral effects of opioids in pigs subjected to abdominal surgery.

Degree: 2005, Swedish University of Agricultural Sciences

URL: http://pub.epsilon.slu.se/939/

► Pigs are commonly used in biomedical research, often subjected to complicated and invasive surgical procedures. The knowledge of appropriate analgesia and anaesthesia in pigs however… (more)

▼ Pigs are commonly used in biomedical research, often subjected to complicated and invasive surgical procedures. The knowledge of appropriate analgesia and anaesthesia in pigs however is limited. Therefore, the general aim of the present thesis was to establish and evaluate opioid analgesia suitable for abdominal surgery in growing pigs. Isoflurane minimal alveolar concentration (MAC) was determined in growing pigs using claw pinching. Thereafter, each pig was randomly studied thrice to determine the MAC values in the following treatments: induction of anaesthesia with medetomidine and tiletamine/zolazepam given intramuscularly (MTZ); MTZ followed by epidural morphine (MTZ/M); and MTZ followed by intramuscular buprenorphine (MTZ/B). Pigs were subjected to abdominal surgery during isoflurane anaesthesia and physiological and behavioural effects of MTZ/M and MTZ/B compared to MTZ were evaluated. Transdermal fentanyl was applied and the effects were evaluated for 60 h in conscious pigs and in pigs treated with MTZ/M. Opioid serum concentrations were monitored up to 72 h after drug administration. Behaviour was analysed utilizing videotape recordings of pigs’ activity level before and after surgery. Induction of anaesthesia with MTZ reduced the isoflurane MAC in pigs by 68%. Additional epidural morphine and systemic buprenorphine decreased MTZ isoflurane MAC by 33% and 50%, respectively. Pigs treated with epidural morphine or systemic buprenorphine prior to abdominal surgery attained surgical anaesthetic depth with reduced isoflurane requirement. Induction of anaesthesia with MTZ improved arterial blood pressure and oxygenation compared to isoflurane induction. Epidural morphine did not influence the cardiorespiratory functions during anaesthesia but systemic buprenorphine affected the respiratory response in spontaneously breathing pigs. The postoperative activity level after epidural morphine was lower but the pigs gained weight and the feed intake was similar compared to before surgery. Combining epidural morphine and transdermal fentanyl resulted in initial return to regular activity levels and weight gain after surgery. Twelve hours after surgery these pigs showed decreased activity but still gained weight. Transdermal fentanyl alone in conscious pigs did not cause inactivity or sedation but resulted in inter-individual variations in fentanyl serum concentrations. Systemic buprenorphine caused unpredictable activity levels with postoperative decrease in weight and feed consumption. The analgesic properties of MTZ contributed to a substantial reduction in concentration of isoflurane required for maintenance of inhalation anaesthesia. Additional preoperative opioid analgesia further reduced the requirements of isoflurane needed to maintain an adequate anaesthetic depth. The opioids evaluated resulted in different behaviour postoperatively. Pigs treated with epidural morphine with or without transdermal fentanyl had good appetite and gained weight after abdominal surgery indicating improved postoperative recovery.

Subjects/Keywords: swine; anaesthesia; analgesics; morphine; pain; behaviour; surgical operations; laboratory diagnosis; swine; anaesthesia; analgesia; epidural morphine; buprenorphine; transdermal fentanyl; minimal alveolar concentration; isoflurane; pain assessment; behaviour

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Malavasi, L. d. M. (2005). Physiological and behavioral effects of opioids in pigs subjected to abdominal surgery. (Doctoral Dissertation). Swedish University of Agricultural Sciences. Retrieved from http://pub.epsilon.slu.se/939/

Chicago Manual of Style (16^th Edition):

Malavasi, Laís de Matos. “Physiological and behavioral effects of opioids in pigs subjected to abdominal surgery.” 2005. Doctoral Dissertation, Swedish University of Agricultural Sciences. Accessed January 23, 2021. http://pub.epsilon.slu.se/939/.

MLA Handbook (7^th Edition):

Malavasi, Laís de Matos. “Physiological and behavioral effects of opioids in pigs subjected to abdominal surgery.” 2005. Web. 23 Jan 2021.

Vancouver:

Malavasi LdM. Physiological and behavioral effects of opioids in pigs subjected to abdominal surgery. [Internet] [Doctoral dissertation]. Swedish University of Agricultural Sciences; 2005. [cited 2021 Jan 23]. Available from: http://pub.epsilon.slu.se/939/.

Council of Science Editors:

Malavasi LdM. Physiological and behavioral effects of opioids in pigs subjected to abdominal surgery. [Doctoral Dissertation]. Swedish University of Agricultural Sciences; 2005. Available from: http://pub.epsilon.slu.se/939/

Texas A&M University

4. Padgett, Ashley Loren. Comparison of Transdermal Fentanyl and Intramuscularly Administered Buprenorphine for Postoperative Pain in Pregnant Sheep.

Degree: MS, Biomedical Sciences, 2018, Texas A&M University

URL: http://hdl.handle.net/1969.1/174041

► Designing perioperative analgesic regimen for ruminants is problematic as pain assessment is difficult and pregnancy adds additional considerations. The aim of this study was to… (more)

▼ Designing perioperative analgesic regimen for ruminants is problematic as pain assessment is difficult and pregnancy adds additional considerations. The aim of this study was to assess the nociceptive properties of intramuscularly administered buprenorphine and transdermally administered fentanyl utilizing a composite pain score system. To better confirm that the observed abnormal behavior was related to pain, the current study attempted to characterize the nociceptive properties of the analgesic agents at a given plasma drug concentration, which has not previously been done. Additionally, the study characterized transplacental movement of analgesic agents via fetal plasma drug concentrations. In this study, we compared intramuscularly administered buprenorphine at a dose of 0.01 mg/kg every 8 hours for 48 hours starting at induction for surgery (n=6) to transdermal fentanyl patches (n=6) applied in the dorsal thorax region 24 hours before surgery at a dose of 2μg/kg/hr for postoperative pain. Ewe blood samples were collected and signs of pain and sedation were measured 24 hours before surgery (time -24), induction to surgery (time 0), and 2, 4, 6, 8, 12, 24, 36, 48 hours after. Using an indwelling fetal arterial catheter that was placed during the surgery, fetal blood pressure was recorded and blood samples were collected. Drug concentrations were measured in maternal and fetal plasma and amniotic fluid. The buprenorphine treated ewes exhibited more pain consistent behaviors than those treated with fentanyl, and their postoperative pain scores were significantly higher than the preoperative value. There were also significant differences in cardiovascular variables from the anesthesia records between the two groups. Overall, transdermal administration of fentanyl provided adequate analgesia with little adverse effects, making it a candidate for optimal postoperative pain management in sheep. Advisors/Committee Members: Washburn, Shannon E (advisor), Lepiz, Mauricio L (committee member), Fajt, Virginia R (committee member), Patterson, Carly (committee member).

Subjects/Keywords: transdermal fentanyl; opioids; pregnant sheep; buprenorphine; analgesia; anesthesia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Padgett, A. L. (2018). Comparison of Transdermal Fentanyl and Intramuscularly Administered Buprenorphine for Postoperative Pain in Pregnant Sheep. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/174041

Chicago Manual of Style (16^th Edition):

Padgett, Ashley Loren. “Comparison of Transdermal Fentanyl and Intramuscularly Administered Buprenorphine for Postoperative Pain in Pregnant Sheep.” 2018. Masters Thesis, Texas A&M University. Accessed January 23, 2021. http://hdl.handle.net/1969.1/174041.

MLA Handbook (7^th Edition):

Padgett, Ashley Loren. “Comparison of Transdermal Fentanyl and Intramuscularly Administered Buprenorphine for Postoperative Pain in Pregnant Sheep.” 2018. Web. 23 Jan 2021.

Vancouver:

Padgett AL. Comparison of Transdermal Fentanyl and Intramuscularly Administered Buprenorphine for Postoperative Pain in Pregnant Sheep. [Internet] [Masters thesis]. Texas A&M University; 2018. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1969.1/174041.

Council of Science Editors:

Padgett AL. Comparison of Transdermal Fentanyl and Intramuscularly Administered Buprenorphine for Postoperative Pain in Pregnant Sheep. [Masters Thesis]. Texas A&M University; 2018. Available from: http://hdl.handle.net/1969.1/174041

The Ohio State University

5. Lovasz, Michael F. Pharmacokinetics and Pharmacodynamics of Fentanyl in Alpacas after Intravenous and Transdermal Administration.

Degree: MS, Veterinary Clinical Sciences, 2016, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1461173885

► The objective of the study reported here was to determine pharmacokinetics and pharmacodynamics of fentanyl in alpacas after intravenous (IV) and transdermal (TD) administration.Fentanyl was… (more)

Subjects/Keywords: Veterinary Services; Pharmacokinetics and Pharmacodynamics of Fentanyl in Alpacas after Intravenous and Transdermal Administration

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lovasz, M. F. (2016). Pharmacokinetics and Pharmacodynamics of Fentanyl in Alpacas after Intravenous and Transdermal Administration. (Masters Thesis). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1461173885

Chicago Manual of Style (16^th Edition):

Lovasz, Michael F. “Pharmacokinetics and Pharmacodynamics of Fentanyl in Alpacas after Intravenous and Transdermal Administration.” 2016. Masters Thesis, The Ohio State University. Accessed January 23, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1461173885.

MLA Handbook (7^th Edition):

Lovasz, Michael F. “Pharmacokinetics and Pharmacodynamics of Fentanyl in Alpacas after Intravenous and Transdermal Administration.” 2016. Web. 23 Jan 2021.

Vancouver:

Lovasz MF. Pharmacokinetics and Pharmacodynamics of Fentanyl in Alpacas after Intravenous and Transdermal Administration. [Internet] [Masters thesis]. The Ohio State University; 2016. [cited 2021 Jan 23]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1461173885.

Council of Science Editors:

Lovasz MF. Pharmacokinetics and Pharmacodynamics of Fentanyl in Alpacas after Intravenous and Transdermal Administration. [Masters Thesis]. The Ohio State University; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1461173885

6. Maurya, Abhijeet. Effect of Solvent Interaction & Soluble Microneedles on Skin Permeability to Drug Molecules.

Degree: PhD, Pharmaceutics and Drug Delivery, 2019, University of Mississippi

URL: https://egrove.olemiss.edu/etd/1635

► Skin forms a formidable barrier protecting the human body from external environmental rigors and excessive loss of water; maintaining equilibrium. The barrier properties of the… (more)

▼ Skin forms a formidable barrier protecting the human body from external environmental rigors and excessive loss of water; maintaining equilibrium. The barrier properties of the skin can be attributed to its unique macromolecular organization and morphology. As a route for drug administration, skin presents a large surface area and can be used for both systemic and localized targeted drug delivery applications offering several advantages over conventional drug therapy; avoidance of first pass metabolism, patient compliance, sustained or controlled delivery for an extended period, to name a few. However, the organized structure of the skin, since intended to prevent entry of adverse chemicals, poses a formidable challenge to molecular transport. From a drug delivery perspective, skin is different from GIT in anatomy and functionality, the former being more permeable to drug molecules. Through various peer reviewed research on the drug transport kinetics through skin, it has been realized that the primary barrier to cutaneous drug transport resides in the Stratum Corneum (SC), the uppermost layer of the skin. The 15-20 μm thick lipophilic, torturous morphology of the SC resembles a brick and mortar structure and imposes a limitation on percutaneous drug transport with only a few molecules having the prerequisite physicochemical characteristics to permeate the intact SC. Thus, drug penetration and subsequent diffusion across the SC is a passive process leading to constraints on the amount of drug that is deliverable to achieve the desired therapeutic effect. To increase the number of candidates for cutaneous delivery and to attain appropriate dose levels requires application of certain enhancement strategies. These approaches employ different mechanisms; (i) an external driving force by iontophoresis (ii) reversible modulation of the SC barrier function by chemical penetration enhancers (iii) creating “easy access” transport channels by microneedles. Nevertheless, a thorough understanding of the molecular transport process across the skin is requisite before formulation strategies could be employed to deliver drugs across the skin in a therapeutically pertinent time-frame. The research presented in this dissertation addresses the knowledge gap that pertains to percutaneous drug absorption by investigating the transport of drug molecules into the skin after a short-term exposure (5 minutes) to aqueous and ethanolic drug solution. Further, the research demonstrates the effect of chemical & physical enhancement approaches: chemical penetration enhancers and microneedles on skin permeability to drug molecules. Advisors/Committee Members: S. Narasimha Murthy, Seongbong Jo, N. P. Dhammika Nanayakkara.

Subjects/Keywords: Convective Transport; Fentanyl; Microneedles; Penetration enhancer; Topical; Transdermal; Pharmacy and Pharmaceutical Sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Maurya, A. (2019). Effect of Solvent Interaction & Soluble Microneedles on Skin Permeability to Drug Molecules. (Doctoral Dissertation). University of Mississippi. Retrieved from https://egrove.olemiss.edu/etd/1635

Chicago Manual of Style (16^th Edition):

Maurya, Abhijeet. “Effect of Solvent Interaction & Soluble Microneedles on Skin Permeability to Drug Molecules.” 2019. Doctoral Dissertation, University of Mississippi. Accessed January 23, 2021. https://egrove.olemiss.edu/etd/1635.

MLA Handbook (7^th Edition):

Maurya, Abhijeet. “Effect of Solvent Interaction & Soluble Microneedles on Skin Permeability to Drug Molecules.” 2019. Web. 23 Jan 2021.

Vancouver:

Maurya A. Effect of Solvent Interaction & Soluble Microneedles on Skin Permeability to Drug Molecules. [Internet] [Doctoral dissertation]. University of Mississippi; 2019. [cited 2021 Jan 23]. Available from: https://egrove.olemiss.edu/etd/1635.

Council of Science Editors:

Maurya A. Effect of Solvent Interaction & Soluble Microneedles on Skin Permeability to Drug Molecules. [Doctoral Dissertation]. University of Mississippi; 2019. Available from: https://egrove.olemiss.edu/etd/1635

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