You searched for subject:(tolerance).
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1.
Greyvenstein, Ockert Frederick.
Phenotyping of High Temperature Susceptibility in Garden Roses (Rosa xhybrida).
Degree: 2013, Texas Digital Library
URL: http://hdl.handle.net/1969; 
http://hdl.handle.net/2249.1/66712
► Roses (Rosa ??hybrida) have delighted man for nearly 5000 years as ornamentals, food, and medicine. A decline in garden roses in the U.S. has been…
(more)
▼ Roses (Rosa ??hybrida) have delighted man for nearly 5000 years as ornamentals, food, and medicine. A decline in garden roses in the U.S. has been observed in the past 30 years, which can be attributed in part to the lack of widely adapted cultivars. Adaptation to high temperature stress is viewed as high priority in breeding programs of all major crops. High temperature stress negatively affects garden rose performance and the quality of flowers produced. The work described in this dissertation is focused on quantifying high temperature susceptibility in garden roses to enable breeders selecting for high temperature performance to make better selections. Seasonal change in flower size and plant architecture was investigated on 14 field grown cultivars. Controlled environment experiments were used to establish the developmental stage where flowers were most sensitive to high temperatures. The effectiveness of detached leaf assays as indicators of thermotolerance by way of cell membrane thermostablity (MTS) and chlorophyll fluorescence is reported on. Flower abscission and leaf necrosis of whole plants shocked in a heat chamber were correlated to summer flower productivity. The mean daily maximum temperature for days 8 - 14 (2WkMax??C) before a flower opens best described the fluctuation in flower dry weight during the growing season. Differences in the rate of change were found among cultivars. Subjecting plants at different stages of development to two week high temperature (36/28 ??C) treatments revealed flowers were most sensitive to high temperatures at the visible bud stage of development. Two week high temperature treatments and high temperature shock (44 ??C, 3 h) both resulted in decreased flower dry weight and increased flower abscission. Initial results favored MTS over chlorophyll fluorescence as indicator of high temperature susceptibility. Further investigation showed no correlation between MTS and summer flower intensity recorded for 18 cultivars. Propensity towards flower abscission and leaf necrosis after a three hour heat shock was negatively correlated (r = - 0.55* and r = -0.64**) with field ratings of summer flower intensity. Selecting against the propensity towards flower abscission and leaf necrosis under heat stress is suggested as phenotyping tools to select against high temperature susceptibility prior to field establishment of roses.
Advisors/Committee Members: Byrne, David H (advisor).
Subjects/Keywords: heat tolerance
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APA (6th Edition):
Greyvenstein, O. F. (2013). Phenotyping of High Temperature Susceptibility in Garden Roses (Rosa xhybrida). (Thesis). Texas Digital Library. Retrieved from http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66712
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Greyvenstein, Ockert Frederick. “Phenotyping of High Temperature Susceptibility in Garden Roses (Rosa xhybrida).” 2013. Thesis, Texas Digital Library. Accessed March 08, 2021.
http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66712.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Greyvenstein, Ockert Frederick. “Phenotyping of High Temperature Susceptibility in Garden Roses (Rosa xhybrida).” 2013. Web. 08 Mar 2021.
Vancouver:
Greyvenstein OF. Phenotyping of High Temperature Susceptibility in Garden Roses (Rosa xhybrida). [Internet] [Thesis]. Texas Digital Library; 2013. [cited 2021 Mar 08].
Available from: http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66712.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Greyvenstein OF. Phenotyping of High Temperature Susceptibility in Garden Roses (Rosa xhybrida). [Thesis]. Texas Digital Library; 2013. Available from: http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66712
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Université de Neuchâtel
2.
Röder, Grégory.
Ecological interactions between two species of leaf beetle,
a rust fungus, and their host plant.
Degree: 2007, Université de Neuchâtel
URL: http://doc.rero.ch/record/8069
► Les champignons parasites et les insectes herbivores sont connus pour leur influence négative sur les populations de plantes, affectant leur reproduction, leur croissance, leur survie,…
(more)
▼ Les champignons parasites et les insectes herbivores
sont connus pour leur influence négative sur les populations de
plantes, affectant leur reproduction, leur croissance, leur survie,
et interférant dans leurs relations avec d’autres espèces. En
fournissant un logement, une protection et une source de nourriture
pour de nombreux organismes, les végétaux représentent un élément
essentiel des écosystèmes terrestres dans lesquels ils permettent
la rencontre d’organismes aussi différents que des champignons
pathogènes et des insectes phytophages. Les relations triangulaires
qui naissent de cette proximité peuvent être directes ou indirectes
lorsque la plante hôte joue le rôle de médiateur. Les insectes
peuvent se nourrir du champignon ou de l’une de ses parties, comme
le mycélium ou les structures reproductrices, et de ce fait réduire
l’ampleur de l’infection ou de la transmission de la maladie. En
revanche, d’autres espèces sont susceptibles de véhiculer des
spores infectieuses et d’inoculer de nouvelles plantes. Ici, les
champignons et les insectes s’influencent directement, positivement
ou négativement, mais leurs relations deviennent indirectes
lorsqu’ils engendrent des perturbations chez leur hôte. Une attaque
fongique est susceptible de produire des changements dans la
qualité de la plante hôte, mais aussi d’y activer des résistances
qui peuvent également agir sur les insectes, grâce à des mécanismes
de défenses croisés. Ainsi, les plantes participent activement à
ces relations en mettant en oeuvre des défenses permanentes ou
activables, impliquant des structures morphologiques, des
substances chimiques internes ou externes, leur phénologie, ou des
stratégies de tolérance. Ce travail est centré sur l’étude des
relations directes et indirectes entre la plante Adenostyles
alliariae, la rouille Uromyces cacaliae, et deux chrysomèles
alpines Oreina elongata et Oreina cacaliae. Dans leur environnement
naturel, régit par des conditions difficiles, leur relation prend
une importance particulière, principalement due à une période
d’activité très courte, mais aussi à cause de la stratégie de
défense des chrysomèles alpines, impliquant des composés
secondaires (pyrrolizidine alcaloïdes) produits par la plante et
séquestrés par ces insectes pour leur propre défense. Dans ce
contexte, le nombre de conséquences possibles est accru.
L’influence de chacun des protagonistes sur les deux autres fut
observée à l’aide d’expériences combinées entre le terrain, le
laboratoire, et l’analyse de composés chimiques. Quatre sites
différents furent choisis au sein les Alpes suisses et italiennes.
Les résultats montrent que des interactions triangulaires
influencent nos rotagonistes, avec des effets sur leur
comportement, leur phénologie, leur cycle de vie, leurs
performances, leur distribution et la dynamique de leurs
populations. Ces conséquences sont majoritairement négatives et les
rares effets positifs ne fournissent pas d’explication valable à
l’apparente continuité de ce système. Néanmoins, un mélange de
défenses, d’évitement et de…
Advisors/Committee Members: Martine (Dir.).
Subjects/Keywords: tolerance
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APA ·
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MLA ·
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APA (6th Edition):
Röder, G. (2007). Ecological interactions between two species of leaf beetle,
a rust fungus, and their host plant. (Thesis). Université de Neuchâtel. Retrieved from http://doc.rero.ch/record/8069
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Röder, Grégory. “Ecological interactions between two species of leaf beetle,
a rust fungus, and their host plant.” 2007. Thesis, Université de Neuchâtel. Accessed March 08, 2021.
http://doc.rero.ch/record/8069.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Röder, Grégory. “Ecological interactions between two species of leaf beetle,
a rust fungus, and their host plant.” 2007. Web. 08 Mar 2021.
Vancouver:
Röder G. Ecological interactions between two species of leaf beetle,
a rust fungus, and their host plant. [Internet] [Thesis]. Université de Neuchâtel; 2007. [cited 2021 Mar 08].
Available from: http://doc.rero.ch/record/8069.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Röder G. Ecological interactions between two species of leaf beetle,
a rust fungus, and their host plant. [Thesis]. Université de Neuchâtel; 2007. Available from: http://doc.rero.ch/record/8069
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Southern California
3.
Hsiung, Hsunwei.
Defect-tolerance framework for general purpose
processors.
Degree: PhD, Electrical Engineering, 2014, University of Southern California
URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/474092/rec/1812
► As CMOS fabrication technology continues to move deeper into nano-scale, circuit’s susceptibility to manufacturing imperfections increases, and the improvements in yield, power and delay, provided…
(more)
▼ As CMOS fabrication technology continues to move
deeper into nano-scale, circuit’s susceptibility to manufacturing
imperfections increases, and the improvements in yield, power and
delay, provided by each major scaling generation have started to
slow down or even reverse. This is especially true for
microprocessors, which use aggressive design and leading-edge
technology. It is increasingly difficult to guarantee their
correctness and conformance to performance specifications, which
leads to reduction in microprocessor yield. Ensuring continuous
benefits from scaling for microprocessors has been a challenge due
to this adverse trend. Classic defect-
tolerance approaches have
been used to mitigate this trend by adding explicit redundancy and
using it to ensure correctness of the circuit layer specifications.
These approaches impose unnecessarily stringent requirements and
incur overheads that increasingly compromise the economics. ❧ In
this dissertation, we introduce a new defect-
tolerance concept by
taking a global view of the role of a microarchitecture module in
the overall system. This view allows the relaxation of the overly
stringent correctness requirements imposed by classic approaches
and opens up opportunities for new defect-
tolerance approaches that
rely on implicit redundancy and hence are uniquely efficient. We
also introduce a framework to systematically explore the space of
possible defect-
tolerance approaches that target microarchitecture
modules under this global view. In addition to approaches that can
be implemented during a microprocessor’s design phase, our
framework also identified post-fabrication approaches which can
salvage microprocessors beyond hardware repair. We demonstrate that
the approaches significantly improve microprocessors’ economics at
wafer-level.
Advisors/Committee Members: Gupta, Sandeep K. (Committee Chair), Annavaram, Murali (Committee Member), Nakano, Aiichiro (Committee Member).
Subjects/Keywords: defect tolerance
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APA ·
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APA (6th Edition):
Hsiung, H. (2014). Defect-tolerance framework for general purpose
processors. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/474092/rec/1812
Chicago Manual of Style (16th Edition):
Hsiung, Hsunwei. “Defect-tolerance framework for general purpose
processors.” 2014. Doctoral Dissertation, University of Southern California. Accessed March 08, 2021.
http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/474092/rec/1812.
MLA Handbook (7th Edition):
Hsiung, Hsunwei. “Defect-tolerance framework for general purpose
processors.” 2014. Web. 08 Mar 2021.
Vancouver:
Hsiung H. Defect-tolerance framework for general purpose
processors. [Internet] [Doctoral dissertation]. University of Southern California; 2014. [cited 2021 Mar 08].
Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/474092/rec/1812.
Council of Science Editors:
Hsiung H. Defect-tolerance framework for general purpose
processors. [Doctoral Dissertation]. University of Southern California; 2014. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/474092/rec/1812
University of Illinois – Chicago
4.
Banerjee, Soumya.
Cookie-Cutter: Achieving Defect/Fault Tolerance For Large-Scale Systems with Highly Unreliable Components.
Degree: 2017, University of Illinois – Chicago
URL: http://hdl.handle.net/10027/22138
► The work proposes generalized “cookie-cutter” defect and fault tolerance approaches for nano-scale systems. The systems under considerations include Parallel Prefix Adders (PPA’s) and Large-scale Many-processor…
(more)
▼ The work proposes generalized “cookie-cutter” defect and fault
tolerance approaches for nano-scale systems. The systems under considerations include Parallel Prefix Adders (PPA’s) and Large-scale Many-processor Systems.
First, we show a systematic approach for designing defect tolerant PPA’s. It does not only allow the designers to select which adder to use in the design, but also gives the designers freedom to select the proper reliability-hardware trade-off point for the design. In addition, using the same systematic approach, we show how highly customizable Sparse PPA’s can be designed.
For design of fault tolerant Many-Processor systems, we propose a novel 2-layered Router-Processing Element (Router-PE) model, which supports repairs of PE faults through a “chain of replacements”: the faulty PE is replaced by a PE in the neighborhood, which is in turn replaced by another PE nearby. This reconfiguration goes on until a spare is reached. We show that such a repair methodology, combined with the model, provides a systematic design approach for Many-Processor Systems facilitating simple lightweight repairs on-the-fly. Physical implementation of such system does not require significantly long interconnect overhead to deliver reasonable reliability.
Advisors/Committee Members: Rao, Wenjing (advisor), Zefran, Milos (committee member), Zhu, Zhichun (committee member), Trivedi, Amit (committee member), Lillis, John (committee member), Rao, Wenjing (chair).
Subjects/Keywords: Defect tolerance; Fault tolerance; Reliability; Reconfigurable Computing
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APA ·
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APA (6th Edition):
Banerjee, S. (2017). Cookie-Cutter: Achieving Defect/Fault Tolerance For Large-Scale Systems with Highly Unreliable Components. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/22138
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Banerjee, Soumya. “Cookie-Cutter: Achieving Defect/Fault Tolerance For Large-Scale Systems with Highly Unreliable Components.” 2017. Thesis, University of Illinois – Chicago. Accessed March 08, 2021.
http://hdl.handle.net/10027/22138.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Banerjee, Soumya. “Cookie-Cutter: Achieving Defect/Fault Tolerance For Large-Scale Systems with Highly Unreliable Components.” 2017. Web. 08 Mar 2021.
Vancouver:
Banerjee S. Cookie-Cutter: Achieving Defect/Fault Tolerance For Large-Scale Systems with Highly Unreliable Components. [Internet] [Thesis]. University of Illinois – Chicago; 2017. [cited 2021 Mar 08].
Available from: http://hdl.handle.net/10027/22138.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Banerjee S. Cookie-Cutter: Achieving Defect/Fault Tolerance For Large-Scale Systems with Highly Unreliable Components. [Thesis]. University of Illinois – Chicago; 2017. Available from: http://hdl.handle.net/10027/22138
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Zambia
5.
Mooya, Dennis.
Evaluation of water use for drought tolerance in Maize (Zea Mays L) Genotypes under deficit irrigation
.
Degree: 2015, University of Zambia
URL: http://hdl.handle.net/123456789/3690
► The problem of drought and erratic rainfall, coupled with crop genotypes (both local and improved varieties) with low water utilisation efficiencies, are major contributors to…
(more)
▼ The problem of drought and erratic rainfall, coupled with crop genotypes (both local and improved varieties) with low water utilisation efficiencies, are major contributors to low productivity of most crops. The poor agricultural productivity among the farming community results in poverty and food insecurity at national level and in low household incomes.
Selection of drought adapted genotypes in breeding programmes and efficient use of water are among the most important approaches in combating climate change effects like droughts and erratic rainfall. This study was conducted to characterise drought tolerance of twelve maize genotypes. An experiment was set up at the National Irrigation Research Station in Mazabuka, to determine the response of these genotypes to three water regimes at 30 %, 60 % and 100 % of crop water requirement (ETc). The twelve maize genotypes were planted at each water regime in a split – plot design arranged in a randomized layout. To evaluate the water utilisation of each maize genotype, water use efficiency, crop water productivity, crop yield response factor and harvest index were determined from the grain yield, above ground biomass and data collected during the experiment.
Deficit irrigation (30 % and 60 % ETc) resulted in crop yield reduction and significant effects on most of the measured parameters. Anthesis – silking interval was shortened, plant girth and height equally decreased with increased water stress at 30 % of ETc. The results showed variations in maize yield and this was attributed to genotype and water regime. The genotypes and water regimes contributed to yield by 30 % and 50.2 %, respectively. The grain yield in genotypes L512, L353, L857 and L07 had a yield advantage of 36.8 %, 34.6 %, 27.6 % and 18.0 %, respectively above the overall mean. Water Use Efficiency (WUE) at 30 % water regime was high in maize genotypes L512, L60, L713 and L857 with 2.412, 1.818, 1.900 and 2.265 kg/mm/ha, respectively. The Crop Yield Response Factor of genotypes L353, L512, L07 and L857 at 60 % water regime were below 1.0 indicating an efficient water use by most genotypes at 60 % water regime which resulted in a seasonal accumulative value of 505.3 mm for the season under study.
Based on the results, genotypes L512, L857, L07 and L353, were selected as drought tolerant genotypes.
Subjects/Keywords: Corn-Drought tolerance
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APA ·
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APA (6th Edition):
Mooya, D. (2015). Evaluation of water use for drought tolerance in Maize (Zea Mays L) Genotypes under deficit irrigation
. (Thesis). University of Zambia. Retrieved from http://hdl.handle.net/123456789/3690
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mooya, Dennis. “Evaluation of water use for drought tolerance in Maize (Zea Mays L) Genotypes under deficit irrigation
.” 2015. Thesis, University of Zambia. Accessed March 08, 2021.
http://hdl.handle.net/123456789/3690.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mooya, Dennis. “Evaluation of water use for drought tolerance in Maize (Zea Mays L) Genotypes under deficit irrigation
.” 2015. Web. 08 Mar 2021.
Vancouver:
Mooya D. Evaluation of water use for drought tolerance in Maize (Zea Mays L) Genotypes under deficit irrigation
. [Internet] [Thesis]. University of Zambia; 2015. [cited 2021 Mar 08].
Available from: http://hdl.handle.net/123456789/3690.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mooya D. Evaluation of water use for drought tolerance in Maize (Zea Mays L) Genotypes under deficit irrigation
. [Thesis]. University of Zambia; 2015. Available from: http://hdl.handle.net/123456789/3690
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
6.
Kumar, Sunil.
Studies on metal tolerance in plants.
Degree: 2011, University of Pune
URL: http://shodhganga.inflibnet.ac.in/handle/10603/2464
► Some metals at lower concentration are essential for cells but all metals are toxic at higher concentrations. Heavy metal pollution of soil and water caused…
(more)
▼ Some metals at lower concentration are essential
for cells but all metals are toxic at higher concentrations. Heavy
metal pollution of soil and water caused by mining, burning of
fossils fuels, smelting of metalliferous ores, and agriculture
waste, is a major environment problem and exposure to these metals
can be toxic to living cells. Use of plants for
decontamination/minimization of heavy metal pollutants has
attracted attention because of the problems associated with
pollutant removal using conventional methods such as soil
replacement, solidification, electro-kinetic extraction and washing
strategies. Phytoremediation is a cost effective emerging
technology based on the use of green plants to clean up the
polluted sites and is accepted publicly. Research efforts made
towards understanding the mechanism of metal tolerance has
generated a great deal of information but it remains ill
understood. Thus, there is scope for research to understand the
mechanism of metal tolerance by various plant species and to
identify the site and form of metal accumulation within plant
system. This thesis entitled “Studies on Metal Tolerance in Plants”
was designed to study the metal stress on different plant species
including a herb (Peanut), a shrub (Jojoba) and a tree (Pongamia).
Peanut (Arachis hypogaea L.) is a unique leguminous plant for its
characteristic behavior to produce the pods underground in direct
contact with soil. It has the double advantage for absorption of Cd
from soil through roots and directly through the shells. Jojoba
(Simmondsia chinensis) is an industrial crop – its seed wax is used
in the cosmetic industry, as a lubricant, etc. The crop has
considerable potential for cultivation in arid and semi-arid
regions. In vitro nodal segments of jojoba respond to salinity in a
similar way as the whole plant, so plant tissue culture technique
could be used for preselection and evaluation of metal tolerance in
this species.
Bibliography p.116-139
Advisors/Committee Members: Hazra, Sulekha.
Subjects/Keywords: Metal tolerance,; Plants
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APA (6th Edition):
Kumar, S. (2011). Studies on metal tolerance in plants. (Thesis). University of Pune. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/2464
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kumar, Sunil. “Studies on metal tolerance in plants.” 2011. Thesis, University of Pune. Accessed March 08, 2021.
http://shodhganga.inflibnet.ac.in/handle/10603/2464.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kumar, Sunil. “Studies on metal tolerance in plants.” 2011. Web. 08 Mar 2021.
Vancouver:
Kumar S. Studies on metal tolerance in plants. [Internet] [Thesis]. University of Pune; 2011. [cited 2021 Mar 08].
Available from: http://shodhganga.inflibnet.ac.in/handle/10603/2464.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kumar S. Studies on metal tolerance in plants. [Thesis]. University of Pune; 2011. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/2464
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
7.
Geetha D Devanagavi.
Fault tolerance and security mechanisms in wireless
sensor networks;.
Degree: Electrical Engineering, 2015, Jain University
URL: http://shodhganga.inflibnet.ac.in/handle/10603/49296
► Fault tolerance and security are two prominent issues in WSNs that involve fault newlinedetection and fault tolerance in WSNs detecting noncompromised nodes and securely newlinetransmitting…
(more)
▼ Fault tolerance and security are two prominent
issues in WSNs that involve fault newlinedetection and fault
tolerance in WSNs detecting noncompromised nodes and securely
newlinetransmitting the data from source to sink through these
faultfree non compromised nodes newlineWSNs composed of large
number of tiny sensor nodes equipped with limited computing and
newlinecommunication capabilities Since low cost sensor nodes are
often deployed in an uncontrolled or even harsh environment they
are prone to have faults It is essential to detect locate the
faulty sensor nodes and exclude them from the network for
transmitting the data Security is becoming a major concern for WSN
protocol designers because of wide security critical application
evesdropping because of wireless communication nature deployed in
harsh environment and limited resources newline
newline
Bibliography 146 - 155 p.
Advisors/Committee Members: Nalini N.
Subjects/Keywords: Fault Tolerance; WSNs
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APA (6th Edition):
Devanagavi, G. D. (2015). Fault tolerance and security mechanisms in wireless
sensor networks;. (Thesis). Jain University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/49296
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Devanagavi, Geetha D. “Fault tolerance and security mechanisms in wireless
sensor networks;.” 2015. Thesis, Jain University. Accessed March 08, 2021.
http://shodhganga.inflibnet.ac.in/handle/10603/49296.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Devanagavi, Geetha D. “Fault tolerance and security mechanisms in wireless
sensor networks;.” 2015. Web. 08 Mar 2021.
Vancouver:
Devanagavi GD. Fault tolerance and security mechanisms in wireless
sensor networks;. [Internet] [Thesis]. Jain University; 2015. [cited 2021 Mar 08].
Available from: http://shodhganga.inflibnet.ac.in/handle/10603/49296.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Devanagavi GD. Fault tolerance and security mechanisms in wireless
sensor networks;. [Thesis]. Jain University; 2015. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/49296
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Penn State University
8.
Nealon, Caitlin Marie.
AGONIST-SPECIFIC MECHANISMS OF CANNABINOID TOLERANCE IN PRECLINICAL MODELS OF ACUTE AND CHRONIC PAIN.
Degree: 2018, Penn State University
URL: https://submit-etda.libraries.psu.edu/catalog/15260cmn181
► Cannabinoids demonstrate substantial potential as pain therapeutics, particularly for treatment of types of chronic pain that do not currently have effective therapies. One barrier to…
(more)
▼ Cannabinoids demonstrate substantial potential as pain therapeutics, particularly for treatment of types of chronic pain that do not currently have effective therapies. One barrier to their use is that
tolerance develops after prolonged treatment, where more drug is required to achieve previous effects.
Tolerance develops as a result of changes in receptor signaling, including receptor desensitization. Desensitization is caused by phosphorylation of cannabinoid receptor 1 (CB1) by a G protein-coupled receptor kinase (GRK), and subsequent association of the receptor with arrestin. We have previously found that
tolerance to delta-9-tetrahydrocannabinol (∆9-THC) is mediated by two distinct signaling mechanisms. Mice expressing a mutant form of CB1, in which the serine residues at two putative phosphorylation sites necessary for desensitization are replaced by non-phosphorylatable alanine (S426A/S430A), display reduced
tolerance to the antinociceptive and hypothermic effects of ∆9-THC. However, we have found that
tolerance to the effects of ∆9-THC on nociceptive pain is only prevented by subsequent inhibition of activation of c-Jun N-terminal kinase (JNK) in desensitization-resistant S426A/S430A mice. The objective of this study is to understand the mechanisms of
tolerance to WIN55,212-2 and CP55,940, both synthetic, high potency cannabinoid agonists. We found that
tolerance to CP55,940 was not significantly altered in S426A/S430A mice in either thermal (tail flick) or inflammatory (formalin test) antinociceptive pain assays or in a model of chronic cisplatin-induced neuropathic pain. In contrast,
tolerance to WIN55,212-2 was significantly delayed (although not abolished) in these tests in desensitization-resistant mice. Interestingly, we observed contrasting effects of inhibiting JNK signaling using the JNK antagonist SP600125 on cannabinoid
tolerance. Disruption of JNK signaling, which consistently delays development of antinociceptive
tolerance to ∆9-THC, actually accelerated
tolerance to the antinociceptive effects of CP55,940.
Tolerance to the antinociceptive effects of WIN55,212-2 was unaffected by SP600125. Collectively, these findings show that
tolerance to cannabinoid agonists develops through different mechanisms, where GRK- and βarrestin2-mediated desensitization of CB1 may be the predominant mechanism responsible for
tolerance to the antinociceptive effects of WIN55,212-2 while JNK signaling contributes to
tolerance to CP55,940, and raises the possibility of complex agonist-specific mechanisms of
tolerance for different cannabinoid agonists. A greater understanding of the mechanisms responsible for these effects is important for the development of better cannabinoid-based therapies, particularly for more effective pain management therapies.
Advisors/Committee Members: Daniel James Morgan, Dissertation Advisor/Co-Advisor, Daniel James Morgan, Committee Chair/Co-Chair, John Ellis, Committee Member, Patricia Sue Grigson-Kennedy, Committee Member, Ira Joseph Ropson, Outside Member.
Subjects/Keywords: pain; tolerance; cannabinoid
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APA (6th Edition):
Nealon, C. M. (2018). AGONIST-SPECIFIC MECHANISMS OF CANNABINOID TOLERANCE IN PRECLINICAL MODELS OF ACUTE AND CHRONIC PAIN. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/15260cmn181
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Nealon, Caitlin Marie. “AGONIST-SPECIFIC MECHANISMS OF CANNABINOID TOLERANCE IN PRECLINICAL MODELS OF ACUTE AND CHRONIC PAIN.” 2018. Thesis, Penn State University. Accessed March 08, 2021.
https://submit-etda.libraries.psu.edu/catalog/15260cmn181.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Nealon, Caitlin Marie. “AGONIST-SPECIFIC MECHANISMS OF CANNABINOID TOLERANCE IN PRECLINICAL MODELS OF ACUTE AND CHRONIC PAIN.” 2018. Web. 08 Mar 2021.
Vancouver:
Nealon CM. AGONIST-SPECIFIC MECHANISMS OF CANNABINOID TOLERANCE IN PRECLINICAL MODELS OF ACUTE AND CHRONIC PAIN. [Internet] [Thesis]. Penn State University; 2018. [cited 2021 Mar 08].
Available from: https://submit-etda.libraries.psu.edu/catalog/15260cmn181.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Nealon CM. AGONIST-SPECIFIC MECHANISMS OF CANNABINOID TOLERANCE IN PRECLINICAL MODELS OF ACUTE AND CHRONIC PAIN. [Thesis]. Penn State University; 2018. Available from: https://submit-etda.libraries.psu.edu/catalog/15260cmn181
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Waterloo
9.
Kazhamiaka, Mikhail.
Sift: Achieving Resource-Efficient Consensus with RDMA.
Degree: 2019, University of Waterloo
URL: http://hdl.handle.net/10012/14596
► Sift is a new consensus protocol for replicating state machines. It disaggregates CPU and memory consumption by creating a novel system architecture enabled by one-sided…
(more)
▼ Sift is a new consensus protocol for replicating state machines. It disaggregates CPU and memory consumption by creating a novel system architecture enabled by one-sided RDMA operations. We show that this system architecture allows us to develop a consensus protocol which centralizes the replication logic. The result is a simplified protocol design with less complex interactions between the participants of the consensus group compared to traditional protocols. The dissaggregated design also enables Sift to reduce deployment costs by sharing backup computational nodes across consensus groups deployed within the same cloud environment. The required storage resources can be further reduced by integrating erasure codes without making significant changes to our protocol. Evaluation results show that in a cloud environment with 100 groups where each group can support up to 2 simultaneous failures, Sift can reduce the cost by 56% compared to an RDMA-based Raft deployment.
Subjects/Keywords: consensus; fault tolerance
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APA (6th Edition):
Kazhamiaka, M. (2019). Sift: Achieving Resource-Efficient Consensus with RDMA. (Thesis). University of Waterloo. Retrieved from http://hdl.handle.net/10012/14596
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kazhamiaka, Mikhail. “Sift: Achieving Resource-Efficient Consensus with RDMA.” 2019. Thesis, University of Waterloo. Accessed March 08, 2021.
http://hdl.handle.net/10012/14596.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kazhamiaka, Mikhail. “Sift: Achieving Resource-Efficient Consensus with RDMA.” 2019. Web. 08 Mar 2021.
Vancouver:
Kazhamiaka M. Sift: Achieving Resource-Efficient Consensus with RDMA. [Internet] [Thesis]. University of Waterloo; 2019. [cited 2021 Mar 08].
Available from: http://hdl.handle.net/10012/14596.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kazhamiaka M. Sift: Achieving Resource-Efficient Consensus with RDMA. [Thesis]. University of Waterloo; 2019. Available from: http://hdl.handle.net/10012/14596
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
10.
Cordova, Adrian.
The Role of Aldehyde Dehydrogrenase 2 In Nitrate Tolerance: Investigation of Low Potency Nitrates and Cross Tolerance
.
Degree: Pharmacology and Toxicology, 2011, Queens University
URL: http://hdl.handle.net/1974/6536
► Organic nitrates such as glyceryl trinitrate (GTN) are commonly used to treat cardiovascular disease. They are prodrugs that require bioactivation for pharmacological activity. Currently, there…
(more)
▼ Organic nitrates such as glyceryl trinitrate (GTN) are commonly used to treat cardiovascular disease. They are prodrugs that require bioactivation for pharmacological activity. Currently, there are two proposed pathways of organic nitrate activation: a high-affinity pathway for high-potency nitrates (GTN and pentaerythrityl tetranitate) and a low-affinity pathway for low-potency nitrates (isosorbide dinitrate (ISDN) and isosorbide mononitrate). A major limitation in the utility of organic nitrates is the rapid onset of tolerance during chronic treatment. Inhibition of the enzymes responsible for bioactivation has been put forward as the major cause of tolerance, and aldehyde dehydrogenase 2 (ALDH2) has been proposed as the primary enzyme responsible for bioactivation in the high-affinity pathway. ALDH2 activity is decreased in GTN-tolerant tissues and it has been suggested that ALDH2 inactivation is the underlying cause of GTN tolerance. However, several aspects of this hypothesis are problematic. My objective was to develop an in vivo model of ISDN tolerance and to use this model to examine the effects of chronic ISDN treatment on ALDH2 activity and on organic nitrate-induced vasodilation. The hypothesis of my research is that the reduced potency of GTN caused by ISDN tolerance is mediated by a mechanism independent of ALDH2 inactivation. ISDN tolerance was induced in rats using an in vivo model in which animals were exposed to 0.8 mg/hr ISDN for 24-96 hr. ALDH2 activity was measured in liver mitochondrial fractions and tolerance was assessed in isolated aortic preparations. There was no inhibition of mitochondrial ALDH2 activity in ISDN-treated animals. However, chronic treatment with ISDN resulted in parallel rightward shifts of both the ISDN and GTN concentration-response curves, which increased with increased duration of exposure
iii
to ISDN. Concentration-response curves for acetylcholine (ACh), sodium nitroprusside (SNP), and diethylamine NONOate were unchanged in ISDN-treated animals. The model of chronic ISDN treatment results in cross tolerance to GTN but does not affect ALDH activity. The data presented in this study indicate no role for ALDH2 in the development of nitrate tolerance.
Subjects/Keywords: Nitrate Tolerance
;
ALDH2
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APA (6th Edition):
Cordova, A. (2011). The Role of Aldehyde Dehydrogrenase 2 In Nitrate Tolerance: Investigation of Low Potency Nitrates and Cross Tolerance
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/6536
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Cordova, Adrian. “The Role of Aldehyde Dehydrogrenase 2 In Nitrate Tolerance: Investigation of Low Potency Nitrates and Cross Tolerance
.” 2011. Thesis, Queens University. Accessed March 08, 2021.
http://hdl.handle.net/1974/6536.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Cordova, Adrian. “The Role of Aldehyde Dehydrogrenase 2 In Nitrate Tolerance: Investigation of Low Potency Nitrates and Cross Tolerance
.” 2011. Web. 08 Mar 2021.
Vancouver:
Cordova A. The Role of Aldehyde Dehydrogrenase 2 In Nitrate Tolerance: Investigation of Low Potency Nitrates and Cross Tolerance
. [Internet] [Thesis]. Queens University; 2011. [cited 2021 Mar 08].
Available from: http://hdl.handle.net/1974/6536.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Cordova A. The Role of Aldehyde Dehydrogrenase 2 In Nitrate Tolerance: Investigation of Low Potency Nitrates and Cross Tolerance
. [Thesis]. Queens University; 2011. Available from: http://hdl.handle.net/1974/6536
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Toronto
11.
Shyu, Wendy Huei-Ping.
Induction of Tolerance: Mechanisms and Implications for Clinical Transplantation.
Degree: 2013, University of Toronto
URL: http://hdl.handle.net/1807/42931
► Therapies that promote tolerance will improve outcomes in solid organ transplantation by eliminating the need for long-term immunosuppression. This thesis investigates two possible tolerance induction…
(more)
▼ Therapies that promote tolerance will improve outcomes in solid organ transplantation by eliminating the need for long-term immunosuppression. This thesis investigates two possible tolerance induction mechanisms: rapamycin induced expression of regulatory T cells and re-education of the immune system using syngeneic hematopoietic stem cell transplantation. Fibrinogen-like protein 2, a effector molecule of regulatory T cells, was also determined as a key mediator in the tolerance induction pathway as depletion of fibrinogen-like protein 2 lead to allograft rejection. The feasibility of using syngeneic hematopoietic stem cells for inducing allograft tolerance was studied by setting up a murine heart and bone marrow transplant model. Syngeneic T-depleted bone marrow transplantation resulted in a slight prolongation of the graft survival time compared to the animals reconstituted with total bone marrow cells. We provide compelling evidence to suggest that fibrinogen-like protein 2 and syngeneic hematopoietic stem cells can possibly be used to induce transplantation tolerance.
MAST
Advisors/Committee Members: Levy, Gary A., Immunology.
Subjects/Keywords: Transplantation; Tolerance; 0982
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APA (6th Edition):
Shyu, W. H. (2013). Induction of Tolerance: Mechanisms and Implications for Clinical Transplantation. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/42931
Chicago Manual of Style (16th Edition):
Shyu, Wendy Huei-Ping. “Induction of Tolerance: Mechanisms and Implications for Clinical Transplantation.” 2013. Masters Thesis, University of Toronto. Accessed March 08, 2021.
http://hdl.handle.net/1807/42931.
MLA Handbook (7th Edition):
Shyu, Wendy Huei-Ping. “Induction of Tolerance: Mechanisms and Implications for Clinical Transplantation.” 2013. Web. 08 Mar 2021.
Vancouver:
Shyu WH. Induction of Tolerance: Mechanisms and Implications for Clinical Transplantation. [Internet] [Masters thesis]. University of Toronto; 2013. [cited 2021 Mar 08].
Available from: http://hdl.handle.net/1807/42931.
Council of Science Editors:
Shyu WH. Induction of Tolerance: Mechanisms and Implications for Clinical Transplantation. [Masters Thesis]. University of Toronto; 2013. Available from: http://hdl.handle.net/1807/42931
University of Florida
12.
Nelson, Andrew S.
Mucosal Tolerance Strategies for Treating Type 1 Diabetes in Non-Obese Diabetic Mice.
Degree: PhD, Veterinary Medical Sciences - Veterinary Medicine, 2018, University of Florida
URL: https://ufdc.ufl.edu/UFE0053997
► Oral tolerance has proven effective for treating animal models of type 1 diabetes (T1D) suggesting it may function to treat human disease. Yet, these strategies…
(more)
▼ Oral
tolerance has proven effective for treating animal models of type 1 diabetes (T1D) suggesting it may function to treat human disease. Yet, these strategies have not translated well to the clinic. One possible reason is the large amount of antigen required for tolerization in humans. Another possibility is the heterologous nature of T1D limits effectiveness of antigen specific monotherapies. To overcome these obstacles we have implemented two complimentary approaches. The first approach utilizes colonization factor antigen I (CFA/I) fimbriae from Escherichia coli. Previously, we have found CFA/I fimbriae to inhibit animal models of multiple sclerosis and arthritis. CFA/I fimbriae initially promotes bystander
tolerance in an antigen independent manner, but ultimately protection is dependent upon antigen specific regulatory T cells (Tregs). Initial studies with CFA/I treatment to prevent T1D showed a 45% reduction in disease incidence and an 8 fold increase in Tregs producing IL-10 and IFN-gamma. CFA/I therapy was optimized and dosing with 5x107 CFUs of LL-CFA/I every 2 weeks was shown to provide superior reduction of insulitis scores and insulin specific cluster of differentiation (CD) 4 and CD8+ T cells. Additionally, optimized therapy suppressed TH1 inflammatory mediators Tbet and IFN-gamma in T cells of the spleen and pancreas. This suppressive phenotype was found to be stable out to 17 weeks of age. We examined the role DCs played in mediated protection and found significant reductions in expression of costimulatory molecules CD86, CD40, and OX40L. Direct infection of BMDCs by LL-CFA/I revealed increased production of TGF-beta, IL-10, and IDO. IDO production was confirmed by fluorescence-activated cell sorting (FACS) analysis of DCs in the spleen and PaLN 3 days after oral treatment. Additionally, co-culture of infected BMDCs was shown to suppress inflammatory mediators without increasing Foxp3 expression. Our complimentary approach utilizes reovirus protein sigma-1 to target microfold cells. Antigen fused to protein sigma-1 have been shown to induce
tolerance using 1000x less protein than conventional methods. Mucosal administration of insulin and GAD protein sigma-1 fusion proteins significantly reduced incidence of T1D in NOD mice and induced IL-10 producing Tregs in the spleen. ( en )
Advisors/Committee Members: PASCUAL,DAVID WAYNE (committee chair), NGUYEN,CUONG (committee member), ZHOU,LIANG (committee member), BRUSKO,TODD MICHAEL (committee member).
Subjects/Keywords: autoimmunity – diabetes – tolerance
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APA (6th Edition):
Nelson, A. S. (2018). Mucosal Tolerance Strategies for Treating Type 1 Diabetes in Non-Obese Diabetic Mice. (Doctoral Dissertation). University of Florida. Retrieved from https://ufdc.ufl.edu/UFE0053997
Chicago Manual of Style (16th Edition):
Nelson, Andrew S. “Mucosal Tolerance Strategies for Treating Type 1 Diabetes in Non-Obese Diabetic Mice.” 2018. Doctoral Dissertation, University of Florida. Accessed March 08, 2021.
https://ufdc.ufl.edu/UFE0053997.
MLA Handbook (7th Edition):
Nelson, Andrew S. “Mucosal Tolerance Strategies for Treating Type 1 Diabetes in Non-Obese Diabetic Mice.” 2018. Web. 08 Mar 2021.
Vancouver:
Nelson AS. Mucosal Tolerance Strategies for Treating Type 1 Diabetes in Non-Obese Diabetic Mice. [Internet] [Doctoral dissertation]. University of Florida; 2018. [cited 2021 Mar 08].
Available from: https://ufdc.ufl.edu/UFE0053997.
Council of Science Editors:
Nelson AS. Mucosal Tolerance Strategies for Treating Type 1 Diabetes in Non-Obese Diabetic Mice. [Doctoral Dissertation]. University of Florida; 2018. Available from: https://ufdc.ufl.edu/UFE0053997
University of Illinois – Urbana-Champaign
13.
Deka, Biplab.
On fault tolerance of hardware samplers.
Degree: MS, 1200, 2014, University of Illinois – Urbana-Champaign
URL: http://hdl.handle.net/2142/50701
► In this research, we evaluate the robustness of hardware samplers to hardware faults. This study was motivated by our observation that several applications use sampling…
(more)
▼ In this research, we evaluate the robustness of hardware samplers to hardware faults. This study was motivated by our observation that several applications use sampling as a primitive and that sampling itself is an approximate method for computation. As such, it might be possible to lower energy consumption of hardware implementations of applications by implementing the samplers using more energy efficient, but fault prone, devices. We implemented a sampler in hardware and characterized its output quality in the presence of stuck-at faults and transient faults using an FPGA based gate level fault injection methodology. To understand the application level implications of such errors made by the sampler, we studied its impact on two applications: particle filtering and clustering using a Dirichlet Process Mixture Model (DPMM). Our results indicate that hardware samplers are indeed robust to hardware faults and that their robustness improves in the context of application level metrics. Specifically, we observed that (a) the two applications can tolerate multiple stuck-at faults in the sampler ( > 5 faults at the same time), (b) the applications can tolerate gate level transient fault rates as high as 2.4 × 10^−4, and (c) only faults in a small number of gates (< 5.2%) affect the output quality of the applications. The results show that there may be significant promise to leveraging this robustness to implement sampling based applications with much higher energy efficiency than what was previously thought possible.
Advisors/Committee Members: Kumar, Rakesh (advisor).
Subjects/Keywords: Sampling; Fault tolerance
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APA (6th Edition):
Deka, B. (2014). On fault tolerance of hardware samplers. (Thesis). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/50701
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Deka, Biplab. “On fault tolerance of hardware samplers.” 2014. Thesis, University of Illinois – Urbana-Champaign. Accessed March 08, 2021.
http://hdl.handle.net/2142/50701.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Deka, Biplab. “On fault tolerance of hardware samplers.” 2014. Web. 08 Mar 2021.
Vancouver:
Deka B. On fault tolerance of hardware samplers. [Internet] [Thesis]. University of Illinois – Urbana-Champaign; 2014. [cited 2021 Mar 08].
Available from: http://hdl.handle.net/2142/50701.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Deka B. On fault tolerance of hardware samplers. [Thesis]. University of Illinois – Urbana-Champaign; 2014. Available from: http://hdl.handle.net/2142/50701
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of New Mexico
14.
Sharp, Pamela.
Constantine's Policy of Religious Tolerance: Was It Tolerant Or Not?.
Degree: Department of Foreign Languages and Literatures, 2011, University of New Mexico
URL: http://hdl.handle.net/1928/12061
► Focusing on Late Antiquity and in particular the fourth century AD, the question of Emperor Constantines policy of religious tolerance is examined. Constantine and his…
(more)
▼ Focusing on Late Antiquity and in particular the fourth century AD, the question of Emperor Constantines policy of religious
tolerance is examined. Constantine and his times and issues introduce the theme. The sincerity of Constantine's Christian belief and his relationship to the Church set the background of the debate, along with a look at three influences upon him, Eusebius of Caesarea, Ossius of Cordova, and Lactantius. Examining the atmosphere or climate gives added criteria for determining Constantine's religious policy. Lactantian views are investigated more fully for his influence on Constantine. Other problems looked at are the controversy over the Edict of Milan, the question of Eusebius' reliability and whether or not Constantine issued a ban on sacrifice. After exploring these issues, it is concluded that Constantine did maintain a policy of religious
tolerance.
Advisors/Committee Members: Graham, Timothy, Graham, Timothy, Paine, Charles, Smith, Warren.
Subjects/Keywords: Constantine; Religious Tolerance
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APA (6th Edition):
Sharp, P. (2011). Constantine's Policy of Religious Tolerance: Was It Tolerant Or Not?. (Masters Thesis). University of New Mexico. Retrieved from http://hdl.handle.net/1928/12061
Chicago Manual of Style (16th Edition):
Sharp, Pamela. “Constantine's Policy of Religious Tolerance: Was It Tolerant Or Not?.” 2011. Masters Thesis, University of New Mexico. Accessed March 08, 2021.
http://hdl.handle.net/1928/12061.
MLA Handbook (7th Edition):
Sharp, Pamela. “Constantine's Policy of Religious Tolerance: Was It Tolerant Or Not?.” 2011. Web. 08 Mar 2021.
Vancouver:
Sharp P. Constantine's Policy of Religious Tolerance: Was It Tolerant Or Not?. [Internet] [Masters thesis]. University of New Mexico; 2011. [cited 2021 Mar 08].
Available from: http://hdl.handle.net/1928/12061.
Council of Science Editors:
Sharp P. Constantine's Policy of Religious Tolerance: Was It Tolerant Or Not?. [Masters Thesis]. University of New Mexico; 2011. Available from: http://hdl.handle.net/1928/12061
15.
Doxaki, Christina.
Regulation of microRNAs during activation of macrophages.
Degree: 2016, University of Crete (UOC); Πανεπιστήμιο Κρήτης
URL: http://hdl.handle.net/10442/hedi/37158
► Endotoxin tolerance occurs to protect the organism from hyperactivation of innate immune responses, primarily mediated by macrophages. Regulation of endotoxin tolerance occurs at multiple levels…
(more)
▼ Endotoxin tolerance occurs to protect the organism from hyperactivation of innate immune responses, primarily mediated by macrophages. Regulation of endotoxin tolerance occurs at multiple levels of cell responses and requires significant changes in gene expression. During macrophage activation, induced expression of miR-155 and miR-146a contributes to the regulation of the inflammatory response and endotoxin tolerance. Herein, we demonstrate that expression of both miRNAs is co-ordinately regulated during endotoxin tolerance by a complex mechanism involving mono-allelic inter-chromosomal association, alterations in histone methyl marks and transcription factor binding. Upon activation of naïve macrophages, Histone3 was tri-methylated at lysine4 (H3K4me3) and NFBp65 was bound on both miR-155 and miR-146a gene loci. However, at the stage of endotoxin tolerance both miR gene loci were occupied by C/EBPβ, NFBp50 and the repressive Histone3 marks H3K9me3. DNA fluorescence in situ hybridization (DNA-FISH) experiments revealed mono-allelic inter-chromosomal co-localization of miR-155 and miR-146a gene loci at the stage of endotoxin tolerance, while RNA-DNA-FISH experiments showed that the co-localized alleles were silenced, suggesting a common repressive mechanism. Genetic ablation of Akt1, which is known to abrogate endotoxin tolerance, abolished induction of loci co-localization and C/EBPβ binding, further supporting that this mechanism occurs specifically in endotoxin tolerance. This thesis demonstrates that two miRNAs are co-ordinately regulated via gene co-localization at the three dimensional chromatin space, similar transcriptional machinery and Histone3 methylation profile, contributing to the development of endotoxin tolerance. Further insight into the role of AKT in regulation of M1/M2 polarization, revealed the essential role of these microRNAs in macrophage phenotype. Akt1 ablation promotes miR-155 expression in LPS-stimulated macrophage. Measuring miR-155 in Akt2-depleted macrophages revealed that Akt2 ablation had the opposite effect, reducing miR-155 expression in both resting and LPS-activated macrophages. Therefore, down-regulation of miR-155 in Akt2-defiecient macrophages results in up-regulation of its target C/EBPβ and, consequently, in the induction of Arg1, a hallmark of M2 macrophage polarization. Akt2 deficiency resulted, however, in a significant upregulation of miR-146a, which mediates M1 phenotype suppression and assure endotoxin tolerance. miR-146a transfection in WT macrophages was able to inhibit iNOS induction while miR-146a suppression in Akt2-depleted mice resulted in upregulation of iNOS expression. The physiological and clinical significance of these miRs in sepsis was supported by further data in humans. Critically ill patients with impaired immune responses (CARS syndrome) are associated with increased miR-155 and miR-146 expression. In vivo transferring of these miRs by using amphoteric liposomes seems to be highly promising, underlining miR-155 and miR-146 as potential novel molecular…
Subjects/Keywords: Μακροφάγα; endotoxin tolerance
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APA (6th Edition):
Doxaki, C. (2016). Regulation of microRNAs during activation of macrophages. (Thesis). University of Crete (UOC); Πανεπιστήμιο Κρήτης. Retrieved from http://hdl.handle.net/10442/hedi/37158
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Doxaki, Christina. “Regulation of microRNAs during activation of macrophages.” 2016. Thesis, University of Crete (UOC); Πανεπιστήμιο Κρήτης. Accessed March 08, 2021.
http://hdl.handle.net/10442/hedi/37158.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Doxaki, Christina. “Regulation of microRNAs during activation of macrophages.” 2016. Web. 08 Mar 2021.
Vancouver:
Doxaki C. Regulation of microRNAs during activation of macrophages. [Internet] [Thesis]. University of Crete (UOC); Πανεπιστήμιο Κρήτης; 2016. [cited 2021 Mar 08].
Available from: http://hdl.handle.net/10442/hedi/37158.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Doxaki C. Regulation of microRNAs during activation of macrophages. [Thesis]. University of Crete (UOC); Πανεπιστήμιο Κρήτης; 2016. Available from: http://hdl.handle.net/10442/hedi/37158
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Otago
16.
van Loon, Fiona Maria.
Assessing Gastrointestinal Tolerance and Palatability of Fibre-enriched Bread: a Randomised Control Trial.
Degree: 2014, University of Otago
URL: http://hdl.handle.net/10523/4735
► Objective: The aim was to produce a fibre-enriched bread that contained 10g of fibre per serve (two slices), an amount approximately equivalent to the deficit…
(more)
▼ Objective: The aim was to produce a fibre-enriched bread that contained 10g of fibre per serve (two slices), an amount approximately equivalent to the deficit in fibre intake between the average intake of adult New Zealanders and the nutrient reference value. This was incorporated in a convenient and widely consumed food vehicle (bread) and tested for palatability and gastrointestinal
tolerance.
Design: Randomised double-blind crossover control trial.
Method: A total of 79 healthy University of Otago students enrolled in the undergraduate Human Nutrition course participated in the study. They were randomised to either a Fruit fibre enriched bread (and control) or a FibreMaxTM enriched bread (and control). Participants consumed approximately ten grams of the test fibre in two slices of bread. The palatability rating of the bread was assessed using a questionnaire composed of six visual analogue scales; visual appeal, smell, taste, texture, aftertaste and overall pleasantness. Gastrointestinal symptoms experienced including bloating, abdominal rumbling, flatulence, abdominal pain, nausea and vomiting were then rated using gastrointestinal questionnaires at baseline and one, two, three, eight and 24 hours post bread consumption.
Results: Both the FibreMaxTM and Fruit fibre-enriched breads were well tolerated. More people reported feeling nauseous after eating the Fruit fibre bread compared with it’s control (p=0.02). There were no other differences between the Fruit fibre bread and it’s control, or between the FibreMaxTM bread and it’s control.
The FibreMaxTM bread was visually less appealing than it’s control (P=0.0039), although the overall palatability scores were not statistically different between the bread types (P=0.87). The Fruit fibre bread was less acceptable and had a lower median score for taste (P=0.0005), smell (P=0.0003), rating of aftertaste (P=0.0000) and overall palatability rating (P=0.0003) compared with it’s control.
Conclusion: Both fibre-enriched breads were digestively tolerated in a single serve. Apart from the Fruit fibre having a poor taste and aftertaste that will require reformulation, the two fibre products created moist and palatable bread. There is place in the market and considerable potential for affordable and palatable bread with 10g fibre in a single serve (two slices), which does not induce gastrointestinal discomfort, such as those used in this study. If developed commercially it has the potential to reduce the gap between a low-fibre consumer’s actual and recommended fibre intake.
Advisors/Committee Members: Venn, Bernard (advisor).
Subjects/Keywords: Dietary Fibre;
Tolerance;
Digestive Tolerance;
Gastrointestinal Symptoms;
Fibre;
Palatability;
Sensory Characteristics;
Gastrointestinal Tolerance
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APA (6th Edition):
van Loon, F. M. (2014). Assessing Gastrointestinal Tolerance and Palatability of Fibre-enriched Bread: a Randomised Control Trial.
(Masters Thesis). University of Otago. Retrieved from http://hdl.handle.net/10523/4735
Chicago Manual of Style (16th Edition):
van Loon, Fiona Maria. “Assessing Gastrointestinal Tolerance and Palatability of Fibre-enriched Bread: a Randomised Control Trial.
” 2014. Masters Thesis, University of Otago. Accessed March 08, 2021.
http://hdl.handle.net/10523/4735.
MLA Handbook (7th Edition):
van Loon, Fiona Maria. “Assessing Gastrointestinal Tolerance and Palatability of Fibre-enriched Bread: a Randomised Control Trial.
” 2014. Web. 08 Mar 2021.
Vancouver:
van Loon FM. Assessing Gastrointestinal Tolerance and Palatability of Fibre-enriched Bread: a Randomised Control Trial.
[Internet] [Masters thesis]. University of Otago; 2014. [cited 2021 Mar 08].
Available from: http://hdl.handle.net/10523/4735.
Council of Science Editors:
van Loon FM. Assessing Gastrointestinal Tolerance and Palatability of Fibre-enriched Bread: a Randomised Control Trial.
[Masters Thesis]. University of Otago; 2014. Available from: http://hdl.handle.net/10523/4735
17.
Schwab, Philip Everett.
Customer Tolerance In Community Pharmacy.
Degree: PhD, Pharmacy Administration, 2014, University of Mississippi
URL: https://egrove.olemiss.edu/etd/1103
► Customers can have an existing relationship with a service provider where they are not satisfied with the services they receive, yet they continue to patronize…
(more)
▼ Customers can have an existing relationship with a service provider where they are not satisfied with the services they receive, yet they continue to patronize the service provider. Why does this happen? Why do these customers remain as patrons of service providers that do not meet expectations and that leave these customers with low satisfaction. This dissertation presents the concept of
tolerance to explain the retention of customers who are not satisfied with a service provider. Specifically, this dissertation examined the concept of customer
tolerance in community pharmacy.
Tolerance is an important concept for consideration because regardless of good intentions and efforts to provide quality service, customers will be disappointed, mistakes will be made by service providers, and service failures will occur. With a dearth of marketing literature focused on the concept of customer
tolerance, other streams of literature were examined to inform this dissertation. Based on theoretical reasoning and evidence identified in the literature, hypotheses were generated to evaluate the concept of customer
tolerance in community pharmacy. Hypothesis 1: service quality is positively associated with customer
tolerance hypothesis 2: customer
tolerance is negatively associated with switching intentions hypothesis 3: psychological switching costs (commitment) are positively associated with customer
tolerance hypothesis 4: economic switching costs are positively associated with customer
tolerance before hypotheses about factors related to customer
tolerance could be tested, a measurement of
tolerance needed to be created because existing measures were not available. Two measures of
tolerance were created for this dissertation; an indirect measure of
tolerance that measured action-based
tolerance and a direct measure of
tolerance that measured trait-based
tolerance. Action-based
tolerance was operationalized as satisfaction and switching intentions, evaluated simultaneously. Trait-based
tolerance was operationalized by a 4-item scale that was developed as part of this dissertation using methods introduced by Churchill (1979) which included interviews with customers to develop items, face validity evaluation to edit the list of items, a national consumer survey to analyze data and finalize the list of items before applying the items within a final survey where data could be analyzed to validate the 4-item scale. Using the final survey data, analytical models were evaluated to test the study hypotheses. The model results indicated support for hypotheses 1 and 2 suggesting that perceptions of service quality are positively related to action-based customer
tolerance and that trait-based customer
tolerance is negatively related to switching intentions. The results also indicated partial support for hypothesis 4, but only that a farther distance to the nearest pharmacy was positively related to action-based
tolerance. The model results did not indicate support for the other economic switching costs that were included for…
Advisors/Committee Members: John P. Bentley, Victoria Bush, Donna West-Strum.
Subjects/Keywords: Customer Relationships; Customer Tolerance; Multivariate; Service Failures; Tolerance; Tolerance Measure; Pharmacy and Pharmaceutical Sciences
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APA (6th Edition):
Schwab, P. E. (2014). Customer Tolerance In Community Pharmacy. (Doctoral Dissertation). University of Mississippi. Retrieved from https://egrove.olemiss.edu/etd/1103
Chicago Manual of Style (16th Edition):
Schwab, Philip Everett. “Customer Tolerance In Community Pharmacy.” 2014. Doctoral Dissertation, University of Mississippi. Accessed March 08, 2021.
https://egrove.olemiss.edu/etd/1103.
MLA Handbook (7th Edition):
Schwab, Philip Everett. “Customer Tolerance In Community Pharmacy.” 2014. Web. 08 Mar 2021.
Vancouver:
Schwab PE. Customer Tolerance In Community Pharmacy. [Internet] [Doctoral dissertation]. University of Mississippi; 2014. [cited 2021 Mar 08].
Available from: https://egrove.olemiss.edu/etd/1103.
Council of Science Editors:
Schwab PE. Customer Tolerance In Community Pharmacy. [Doctoral Dissertation]. University of Mississippi; 2014. Available from: https://egrove.olemiss.edu/etd/1103
University of Zambia
18.
Neshamba, Mubaiwa Saul.
Variability for Drought Tolerance in finger millet[eleusine coracana(L.)]accessions from Zambia
.
Degree: 2011, University of Zambia
URL: http://hdl.handle.net/123456789/244
► Finger millet \Eleusine coracana (L.) Gaertn.] is an important traditional food security crop in 2 remote and dry areas of northern Zambia. Its several major…
(more)
▼ Finger millet \Eleusine coracana (L.) Gaertn.] is an important traditional food security crop
in 2 remote and dry areas of northern Zambia. Its several major uses include porridge, bread,
malt, beverages, fodder and popped products. Yields in these areas are severely limited by
drought. Drought is expected to occur with increased frequency and intensity in future with
climate change. Development of tolerant varieties is a more sustainable way to cope with
recurrent drought for small scale growers. Limited research on tolerance to drought in finger
millet in Zambia has been done. As a result only a few varieties adapted to the high rainfall
region have been developed and promoted. Two hundred and fifteen accessions in the
national collection have not been evaluated for the trait. As a result very little is known about
their variability in the trait. Assessment of variability is important for effective selection.
Variation in 12 putative morphological and agronomic traits of drought tolerance in 203
accessions was studied in a wooden box Randomized Complete Block Design off-season in 2
environments, one with and the other without stress, on an Acrisol in northern Zambia. One
sample T-test of differences in attributes of traits showed no significant difference between
test environments in grain weight (GW, p = 0.744). The test, however, showed significant
differences in spike length (SL,/? = 0.027); highly significant differences in biomass (BW, p
< 0.001) and chaff weight (CW,p < 0.001), days to 50 % flowering (DTP,/? < 0.001), pest
and disease susceptibility (PDS, p < 0.007), plant height (PH, p < 0.001), number of
productive tillers (NPT, p < 0.001), spike weight per plot (SY, p < 0.001) and stay-green
characteristic (SGC, p < 0.001). Withholding water for 5 days during flowering reduced SL
by 3.4 %, BW by 3.1 %, SGC by , CW by, PDS by 10.5 %, NPT by 40.0 %), and SY by 48.5
% and increased PH and DTP by 3.1 and 4.3 %, respectively. One-way analysis of variance
detected significant differences among accessions in SY (p = 0.032) under optimal
conditions. The same analysis detected significant differences in number of spikes per panicle
(SN,/p = 0.014) and SGC; and highly significant differences in PDS (p = 0.001) under stress.
Eighty-three accessions outweighed the best check (FMM 165 = 2.500 + 1.000 kg/plot) in SY
under optimal conditions. Accession ZM 3813 had the highest SY (6.450+1.000 kg/plot) and
ZM 203 (0.200 + 1.000 kg/plot) the lowest in the environment. Under stress 92 accessions
exceeded the best check (Nyika = 5.923 + 1.3825 - same and 1.5457 - different block) in SN.
ZM 3825 had the largest attribute (8.706 ± 1.3825, 1.5457) and ZM 193 the smallest (2.631).
In SGC 77 accessions were scored better than the best check, FMM 165. ZM 225 (5.222 +
0.7643, 0.8545), ZM 245 (5.222 + 0.7643, 0.8545), and ZM 112 (4.972 ± 0.7643, 0.8545)
were scored the best and 37 others the poorest in the trait. And in PDS 31 accessions had
better scores than the best check (Senga = 3.000 +0.0151,…
Subjects/Keywords: Finger Millet – drought tolerance – Zambia
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APA (6th Edition):
Neshamba, M. S. (2011). Variability for Drought Tolerance in finger millet[eleusine coracana(L.)]accessions from Zambia
. (Thesis). University of Zambia. Retrieved from http://hdl.handle.net/123456789/244
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Neshamba, Mubaiwa Saul. “Variability for Drought Tolerance in finger millet[eleusine coracana(L.)]accessions from Zambia
.” 2011. Thesis, University of Zambia. Accessed March 08, 2021.
http://hdl.handle.net/123456789/244.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Neshamba, Mubaiwa Saul. “Variability for Drought Tolerance in finger millet[eleusine coracana(L.)]accessions from Zambia
.” 2011. Web. 08 Mar 2021.
Vancouver:
Neshamba MS. Variability for Drought Tolerance in finger millet[eleusine coracana(L.)]accessions from Zambia
. [Internet] [Thesis]. University of Zambia; 2011. [cited 2021 Mar 08].
Available from: http://hdl.handle.net/123456789/244.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Neshamba MS. Variability for Drought Tolerance in finger millet[eleusine coracana(L.)]accessions from Zambia
. [Thesis]. University of Zambia; 2011. Available from: http://hdl.handle.net/123456789/244
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Pretoria
19.
Karzis, Joanne.
Intramammary antibiotics in dairy goats : withdrawal
periods and tissue tolerance
.
Degree: 2008, University of Pretoria
URL: http://upetd.up.ac.za/thesis/available/etd-07242008-084703/
► The aim of this study was to determine withdrawal periods and tissue tolerance of intramammary antibiotics (Curaclox LC, Spectrazol Milking Cow and Rilexine 200 LC)…
(more)
▼ The aim of this study was to determine withdrawal
periods and tissue
tolerance of intramammary antibiotics (Curaclox
LC, Spectrazol Milking Cow and Rilexine 200 LC) in goats, measured
in different ways, and to evaluate the effects of related factors.
Method: Three experimental trials were conducted. Trial 1 and Trial
2 were conducted at the Faculty of Veterinary Science,
Onderstepoort using the goat herd of the Onderstepoort Teaching
Animal Unit (OTAU) (Herd A), while Trial 3 was conducted on a
commercial goat dairy in the Limpopo Province of South Africa (Herd
B). In addition, four goats with clinical mastitis from a
smallholding close to the Faculty of Veterinary Science at
Onderstepoort were studied (Herd C). This herd consisted of 13
lactating Saanen and Saanen/Toggenburg crossbred dairy goats. In
all trials foremilk was stripped, teats were disinfected and a milk
sample was taken from each udder half of each goat (half-milk
samples). In all three trials the following milk samples were
taken: two sets of half samples and a composite sample (before,
during and after treatment). The California Milk Cell Test (CMCT)
and conductivity measurements were performed. In Trial 3 the
conductivity meter became non-functional on the second day, and
thus the conductivity test was eliminated from then on. Each udder
half was milked separately and milk volume was recorded. The
temperature of goats was taken and recorded to identify sick
animals. All goats in the treatment group were treated. In all
three trials after treatment, sampling continued until SCC returned
to baseline and until there were at least two consecutive negative
TRIS tests for each goat, approximately 10 days. Milk production
was based on the following milk production groups: low (less than
1.3L), medium (1.3L to 1.5L) and high (greater than 1.5L) daily
milk production. The antibiotics used in these trials were selected
for being commonly used, broad-spectrum preparations. Trial 1, a
semi-synthetic penicillin based intramammary preparation (Curaclox
LC, which contains 75mg sodium ampicillin and 200mg sodium
cloxacillin per dose plus blue dye). Curaclox LC G2615, (Norbrook
(Pharmacia AH) P.O. Box 10698 Centurion, 0046), cloxacillin 200mg,
ampicillin 75mg, blue dye/ 4.5g syringe. Trial 2, a cefuroxime
250mg based intramammary product (Spectrazol Milking Cow,
Schering-Plough). Spectrazol milking cow, cefuroxime, 250mg, S4
Intramammary Injection 83/594, (Schering-Plough Animal Health, P.O.
BOX 46, Isando, 1600). Trial 3, a cephalexin 100mg, neomycin
sulphate 100mg and prednisolone based intramammary product,
Rilexine (SA) 200LC injection 83/638, (Logos Agvet (Virbac),
Private bag X115, Halfway House, 1685). Curaclox LC G2615, Norbrook
(Pharmacia AH), cloxacillin 200mg, ampicillin 75mg, blue dye/ 4.5g
syringes. In the clinical mastitis cases (Herd C); Goat 1 was
treated with Spectrazol milking cow (as above), Goat 2 was treated
with Curaclox LC (as above), Goat 3 was treated with Curaclox LC in
the left udder half and Goat 4 was treated with Curaclox LC in the…
Advisors/Committee Members: Prof E F Donkin (advisor), Dr I M Petzer (advisor).
Subjects/Keywords: Intramammary antibiotics;
Tissue tolerance;
UCTD
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Manager
APA (6th Edition):
Karzis, J. (2008). Intramammary antibiotics in dairy goats : withdrawal
periods and tissue tolerance
. (Masters Thesis). University of Pretoria. Retrieved from http://upetd.up.ac.za/thesis/available/etd-07242008-084703/
Chicago Manual of Style (16th Edition):
Karzis, Joanne. “Intramammary antibiotics in dairy goats : withdrawal
periods and tissue tolerance
.” 2008. Masters Thesis, University of Pretoria. Accessed March 08, 2021.
http://upetd.up.ac.za/thesis/available/etd-07242008-084703/.
MLA Handbook (7th Edition):
Karzis, Joanne. “Intramammary antibiotics in dairy goats : withdrawal
periods and tissue tolerance
.” 2008. Web. 08 Mar 2021.
Vancouver:
Karzis J. Intramammary antibiotics in dairy goats : withdrawal
periods and tissue tolerance
. [Internet] [Masters thesis]. University of Pretoria; 2008. [cited 2021 Mar 08].
Available from: http://upetd.up.ac.za/thesis/available/etd-07242008-084703/.
Council of Science Editors:
Karzis J. Intramammary antibiotics in dairy goats : withdrawal
periods and tissue tolerance
. [Masters Thesis]. University of Pretoria; 2008. Available from: http://upetd.up.ac.za/thesis/available/etd-07242008-084703/
University of Pretoria
20.
[No author].
Evaluation and selection of 20 sorghum [Sorghum bicolor
(L.) Moench] genotypes for drought tolerance
.
Degree: 2010, University of Pretoria
URL: http://upetd.up.ac.za/thesis/available/etd-10222010-125350/
► A field study was conducted at ARC - Grain Crops Institute, Potchefstroom Experimental Farm and at Taung Crop Production Center during 2006/07 summer growing season.…
(more)
▼ A field study was conducted at ARC - Grain Crops
Institute, Potchefstroom Experimental Farm and at Taung Crop
Production Center during 2006/07 summer growing season. Twenty
sorghum genotypes were planted in two separate blocks, under full
irrigation and rain fed conditions with plot size of 4 rows x 5 m x
0.9 m giving a density of 55 555 plants ha-1. The experiment was
laid out in a randomised complete block design replicated three
times. The irrigated block received scheduled irrigation from
planting until maturity, while the rain fed block received
irrigation prior to germination only. Agronomic traits measured
were plant height, stem diameter, biomass, flowering date, panicle
exertion, panicle length, leaf area, grain yield, and thousand seed
mass at Potchefstroom and Taung experiments. Drought susceptibility
index (DSI) was quantified using the formula: DSI = [1 - (Ydi/
Ypi)]/ [1 - (YD/YP)] and %yield reduction (%YR) was calculated
using the formula: %YR = (Ypi –Ydi)/ Ypi x 100. Significant
variations among genotypes with regard to grain yield (GYLD), plant
height (PH), panicle length (PL), biomass (BM), stem diameter (SD),
panicle exertion (PEx), and 1000 seed mass (TSM) were observed at
Potchefstroom under rain fed conditions, while under irrigated
conditions significant variations were only observed for GYLD, PH,
PL, BM, days to 50% flowering (DF), SD, leaf area (LA), PEx and
TSM. At Potchefstroom genotypes varied significantly with regard to
PH, PL, BM, DF, SD, LA, PEx and TSM under rain fed conditions,
while under irrigated conditions genotypes varied with all traits
measured with exception of harvest index (HI) and relative water
content (RWC). At Potchefstroom, soil water deficits significantly
affected GYLD, PH, HI, PEx and RWC, while at Potchefstroom soil
water deficits significantly affected GYLD, PH, SD, LA, PEx, TSM
and RWC. Genotypes varied with their level of resistance/
susceptibility to soil water deficits at both Potchefstroom and
Taung. Some remarkable correlations among traits measured were
observed under rain fed and irrigated conditions and across the
treatments at both Potchefstroom and Taung. At Potchefstroom,
significant correlation was only observed between drought
susceptibility index (DSI) and PH under rain fed conditions, while
at Potchefstroom negative and significant correlation was only
observed between DSI and GYLD under rain fed conditions. At
Potchefstroom, GYLD under rain fed significantly related to GYLD
under irrigated conditions and across the treatments. However, GYLD
under irrigated conditions significantly related to GYLD across the
treatments. At Potchefstroom, GYLD under rain fed conditions
significantly correlated with GYLD across soil water regimes, while
GYLD under irrigated conditions significantly correlated with GYLD
across the treatments. Genotypes that exhibited the combination of
high yield potential and resistant traits were recommended.
Genotypes that exhibited high resistant traits with low yield
potential were recommended for breeders to incorporate those…
Advisors/Committee Members: Prof P Soundy (advisor).
Subjects/Keywords: Drought tolerance;
Sorghum;
UCTD
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APA (6th Edition):
author], [. (2010). Evaluation and selection of 20 sorghum [Sorghum bicolor
(L.) Moench] genotypes for drought tolerance
. (Masters Thesis). University of Pretoria. Retrieved from http://upetd.up.ac.za/thesis/available/etd-10222010-125350/
Chicago Manual of Style (16th Edition):
author], [No. “Evaluation and selection of 20 sorghum [Sorghum bicolor
(L.) Moench] genotypes for drought tolerance
.” 2010. Masters Thesis, University of Pretoria. Accessed March 08, 2021.
http://upetd.up.ac.za/thesis/available/etd-10222010-125350/.
MLA Handbook (7th Edition):
author], [No. “Evaluation and selection of 20 sorghum [Sorghum bicolor
(L.) Moench] genotypes for drought tolerance
.” 2010. Web. 08 Mar 2021.
Vancouver:
author] [. Evaluation and selection of 20 sorghum [Sorghum bicolor
(L.) Moench] genotypes for drought tolerance
. [Internet] [Masters thesis]. University of Pretoria; 2010. [cited 2021 Mar 08].
Available from: http://upetd.up.ac.za/thesis/available/etd-10222010-125350/.
Council of Science Editors:
author] [. Evaluation and selection of 20 sorghum [Sorghum bicolor
(L.) Moench] genotypes for drought tolerance
. [Masters Thesis]. University of Pretoria; 2010. Available from: http://upetd.up.ac.za/thesis/available/etd-10222010-125350/
Universiteit Utrecht
21.
André, B.J.
Improving cold tolerance in tomato plants using natural variation.
Degree: 2012, Universiteit Utrecht
URL: http://dspace.library.uu.nl:8080/handle/1874/250525
► The demand for food and fuel is increasing due to the rising human population. Therefore are their new strategies needed to increase crop yield. Plants…
(more)
▼ The demand for food and fuel is increasing due to the rising human population. Therefore are their new strategies needed to increase crop yield. Plants suffer from low temperatures which leads to damage to fruit and plant growth. Even non freezing temperatures can have a dramatic effect on plant development. Better insight into cold acclimation responses of plants will lead to better protection to low temperatures. One well examined process that is active during cold acclimation is the c-repeat-binding factor (CBF) regulon. This CBF regulon regulates multiple genes that in turn are responsible for a cold acclimation response. However, not all reactions of the plant are explained by the CBF regulon, therefore more pathways need to be involved.
This proposal will search for other pathways that are involved in cold acclimation. This will be done by analyzing tomato varieties that grow on high altitudes with 1) micro array studies and 2) QTL mapping. Identified candidate genes will be studied in function by transforming Arabidopsis plants. It will also be tested if these candidate genes are connected to the CBF regulon or if they regulated the CBF regulon. Heretofore CBF knockout mutants of Arabidopsis will be used and candidate genes will be introduced. The newly identified related genes can be used to improve crop performance even further and keep up with human demand.
Advisors/Committee Members: Pierik, Dr. R..
Subjects/Keywords: Cold tolerance; tomato; natural variation
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APA (6th Edition):
André, B. J. (2012). Improving cold tolerance in tomato plants using natural variation. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/250525
Chicago Manual of Style (16th Edition):
André, B J. “Improving cold tolerance in tomato plants using natural variation.” 2012. Masters Thesis, Universiteit Utrecht. Accessed March 08, 2021.
http://dspace.library.uu.nl:8080/handle/1874/250525.
MLA Handbook (7th Edition):
André, B J. “Improving cold tolerance in tomato plants using natural variation.” 2012. Web. 08 Mar 2021.
Vancouver:
André BJ. Improving cold tolerance in tomato plants using natural variation. [Internet] [Masters thesis]. Universiteit Utrecht; 2012. [cited 2021 Mar 08].
Available from: http://dspace.library.uu.nl:8080/handle/1874/250525.
Council of Science Editors:
André BJ. Improving cold tolerance in tomato plants using natural variation. [Masters Thesis]. Universiteit Utrecht; 2012. Available from: http://dspace.library.uu.nl:8080/handle/1874/250525
22.
Ahmed Tanvir.
Techniques to Reduce the Overhead and to Improve the Robustness in a Fault Tolerable Reconfigurable Architecture : 再構成可能アーキテクチャのための低オーバーヘッド高信頼化手法; サイコウセイ カノウ アーキテクチャ ノ タメ ノ テイオーバーヘッド コウシンライカ シュホウ.
Degree: 博士(工学), Nara Institute of Science and Technology / 奈良先端科学技術大学院大学
URL: http://hdl.handle.net/10061/9305
Subjects/Keywords: Fault-tolerance
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APA ·
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APA (6th Edition):
Tanvir, A. (n.d.). Techniques to Reduce the Overhead and to Improve the Robustness in a Fault Tolerable Reconfigurable Architecture : 再構成可能アーキテクチャのための低オーバーヘッド高信頼化手法; サイコウセイ カノウ アーキテクチャ ノ タメ ノ テイオーバーヘッド コウシンライカ シュホウ. (Thesis). Nara Institute of Science and Technology / 奈良先端科学技術大学院大学. Retrieved from http://hdl.handle.net/10061/9305
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Tanvir, Ahmed. “Techniques to Reduce the Overhead and to Improve the Robustness in a Fault Tolerable Reconfigurable Architecture : 再構成可能アーキテクチャのための低オーバーヘッド高信頼化手法; サイコウセイ カノウ アーキテクチャ ノ タメ ノ テイオーバーヘッド コウシンライカ シュホウ.” Thesis, Nara Institute of Science and Technology / 奈良先端科学技術大学院大学. Accessed March 08, 2021.
http://hdl.handle.net/10061/9305.
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Tanvir, Ahmed. “Techniques to Reduce the Overhead and to Improve the Robustness in a Fault Tolerable Reconfigurable Architecture : 再構成可能アーキテクチャのための低オーバーヘッド高信頼化手法; サイコウセイ カノウ アーキテクチャ ノ タメ ノ テイオーバーヘッド コウシンライカ シュホウ.” Web. 08 Mar 2021.
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Vancouver:
Tanvir A. Techniques to Reduce the Overhead and to Improve the Robustness in a Fault Tolerable Reconfigurable Architecture : 再構成可能アーキテクチャのための低オーバーヘッド高信頼化手法; サイコウセイ カノウ アーキテクチャ ノ タメ ノ テイオーバーヘッド コウシンライカ シュホウ. [Internet] [Thesis]. Nara Institute of Science and Technology / 奈良先端科学技術大学院大学; [cited 2021 Mar 08].
Available from: http://hdl.handle.net/10061/9305.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.
Council of Science Editors:
Tanvir A. Techniques to Reduce the Overhead and to Improve the Robustness in a Fault Tolerable Reconfigurable Architecture : 再構成可能アーキテクチャのための低オーバーヘッド高信頼化手法; サイコウセイ カノウ アーキテクチャ ノ タメ ノ テイオーバーヘッド コウシンライカ シュホウ. [Thesis]. Nara Institute of Science and Technology / 奈良先端科学技術大学院大学; Available from: http://hdl.handle.net/10061/9305
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.
Nelson Mandela Metropolitan University
23.
Venter, Teneille.
The effects of three carbohydrate supplementation protocols on the blood glucose levels in type I diabetic subjects during a 60 minute bout on the treadmill.
Degree: Faculty of Health Sciences, 2014, Nelson Mandela Metropolitan University
URL: http://hdl.handle.net/10948/4157
► Diabetes associated complications make management during exercise complex (Brugnara, Vinaixa, Murillo, Samino, Rodriguez, Beltran, Lerin, Davison, Correig & Novials, 2012). Research on the prevention of…
(more)
▼ Diabetes associated complications make management during exercise complex (Brugnara, Vinaixa, Murillo, Samino, Rodriguez, Beltran, Lerin, Davison, Correig & Novials, 2012). Research on the prevention of such challenges is of paramount importance. The aim of this study was to determine the effects of three different carbohydrate supplementation protocols on blood glucose levels after every 10 minutes of a 60 minute exercise bout at 65 to 75 % HRR on the treadmill as well as every half hour during a two hour post exercise recovery period. The three protocols implemented after a standardized pre-exercise meal were: control protocol (no carbohydrate supplementation), protocol 1 (one carbohydrate supplementation of 15 grams given at 30 minutes) and protocol 2 (two carbohydrate supplementation of 15 grams given at 30 minutes and 45 minutes). A total of 32 participants took part in the study (Mean age: 32.84 ±12.12). All participants were submitted to all three protocols. Statistical and practical significant differences were found between blood glucose levels of protocol 0 and protocol 1 (MDIF = 2.62 ± 3.99 mmol.L – ‐1) at 20 minutes of the exercise duration (p=.024;d=0.42). Statistical and practical significant differences in blood glucose levels with protocol 0 rendering the higher glucose values were also found between protocols 0 and 2 at 10 minutes (MDIF = 3.44 ± 5.54 mmol.L – ‐1; p=.001;d=0.62), 20 minutes (MDIF = 3.32 ± 5.23 mmol.L – ‐1; p=.001;d=0.63) and 30 minutes of exercise (MDIF = 2.81 ± 5.40 mmol.L – ‐1; p=.006;d=0.52) as well as between the mean minimum (M0 = 9.49 ± 4.51 mmol.L – ‐1 and M2 = 7.28 ± 4.07 mmol.L – ‐1; p=.013;d=0.46), mean maximum (M0 = 12.73 ± 5.51 mmol.L – ‐1 and M2 = 10.07 ± 4.63 mmol.L – ‐1; p=.015;d=0.46) and overall mean (M0 = 9.07 ± 4.88 mmol.L – ‐1 and M2 = 8.53 ± 4.25 mmol.L – ‐1; p=.011;d=0.48) with protocol 0 rendering the higher glucose values in all these comparisons. It was concluded that carbohydrate supplementation during exercise affects blood glucose levels positively particularly considering the significant difference found between protocol 0 and 2. Whilst protocol 2 also resulted in less fluctuations in the blood glucose levels during exercise and minimum, overall mean and maximum blood glucose values were closer to “normal/safe” range, there was no conclusive evidence that protocol 2 was better than protocol 1.
Subjects/Keywords: Glucose tolerance tests; Diabetes
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APA ·
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CSE |
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APA (6th Edition):
Venter, T. (2014). The effects of three carbohydrate supplementation protocols on the blood glucose levels in type I diabetic subjects during a 60 minute bout on the treadmill. (Thesis). Nelson Mandela Metropolitan University. Retrieved from http://hdl.handle.net/10948/4157
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Venter, Teneille. “The effects of three carbohydrate supplementation protocols on the blood glucose levels in type I diabetic subjects during a 60 minute bout on the treadmill.” 2014. Thesis, Nelson Mandela Metropolitan University. Accessed March 08, 2021.
http://hdl.handle.net/10948/4157.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Venter, Teneille. “The effects of three carbohydrate supplementation protocols on the blood glucose levels in type I diabetic subjects during a 60 minute bout on the treadmill.” 2014. Web. 08 Mar 2021.
Vancouver:
Venter T. The effects of three carbohydrate supplementation protocols on the blood glucose levels in type I diabetic subjects during a 60 minute bout on the treadmill. [Internet] [Thesis]. Nelson Mandela Metropolitan University; 2014. [cited 2021 Mar 08].
Available from: http://hdl.handle.net/10948/4157.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Venter T. The effects of three carbohydrate supplementation protocols on the blood glucose levels in type I diabetic subjects during a 60 minute bout on the treadmill. [Thesis]. Nelson Mandela Metropolitan University; 2014. Available from: http://hdl.handle.net/10948/4157
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
24.
Takagi, Takehiro.
Inhibition of Allergic Bronchial Asthma by Thrombomodulin Is Mediated by Dendritic Cells.
Degree: 博士(医学), 2017, Mie University / 三重大学
URL: http://hdl.handle.net/10076/14732
► Rationale: Bronchial asthma is caused by inappropriate acquired immune responses to environmental allergens. It is a major health problem, with a prevalence that is rapidly…
(more)
▼ Rationale: Bronchial asthma is caused by inappropriate acquired immune responses to environmental allergens. It is a major health problem, with a prevalence that is rapidly increasing. Curative therapy is not currently available.Objectives: To test the hypothesis that thrombomodulin (TM) inhibits allergic bronchial asthma by inducing tolerogenic dendritic cells (DCs).Methods: The protective effect of TM was evaluated using a murine asthma model. Asthma was induced in mice by exposure to chicken egg ovalbumin, and the effects of inhaled TM or TM-treated DCs were assessed by administering before ovalbumin exposure.Measurements and Main Results: Treatment with TM protects against bronchial asthma measured as improved lung function and reduced IgE and cells in alveolar lavage fluid by inducing tolerogenic dendritic dells. These are characterized by high expression of surface TM (CD141/TM+) and low expression of maturation markers and possess reduced T-cell costimulatory activity. The CD141/TM+ DCs migrate less toward chemokines, and after TM treatment there are fewer DCs in the draining lymph node and more in the lungs. The TM effect is independent of its role in coagulation. Rather, it is mediated via the TM lectin domain directly interacting with the DCs.Conclusions: The results of this study show that TM is a modulator of DC immunostimulatory properties and a novel candidate drug for the prevention of bronchial asthma in atopic patients.Rationale: Bronchial asthma is caused by inappropriate acquired immune responses to environmental allergens. It is a major health problem, with a prevalence that is rapidly increasing. Curative therapy is not currently available.Objectives: To test the hypothesis that thrombomodulin (TM) inhibits allergic bronchial asthma by inducing tolerogenic dendritic cells (DCs).Methods: The protective effect of TM was evaluated using a murine asthma model. Asthma was induced in mice by exposure to chicken egg ovalbumin, and the effects of inhaled TM or TM-treated DCs were assessed by administering before ovalbumin exposure.Measurements and Main Results: Treatment with TM protects against bronchial asthma measured as improved lung function and reduced IgE and cells in alveolar lavage fluid by inducing tolerogenic dendritic dells. These are characterized by high expression of surface TM (CD141/TM+) and low expression of maturation markers and possess reduced T-cell costimulatory activity. The CD141/TM+ DCs migrate less toward chemokines, and after TM treatment there are fewer DCs in the draining lymph node and more in the lungs. The TM effect is independent of its role in coagulation. Rather, it is mediated via the TM lectin domain directly interacting with the DCs.Conclusions: The results of this study show that TM is a modulator of DC immunostimulatory properties and a novel candidate drug for the prevention of bronchial asthma in atopic patients.
本文 / Department of Immunology, Mie University School of Medicine
52
Subjects/Keywords: asthma; coagulation; dendritic cells; tolerance
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APA ·
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APA (6th Edition):
Takagi, T. (2017). Inhibition of Allergic Bronchial Asthma by Thrombomodulin Is Mediated by Dendritic Cells. (Thesis). Mie University / 三重大学. Retrieved from http://hdl.handle.net/10076/14732
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Takagi, Takehiro. “Inhibition of Allergic Bronchial Asthma by Thrombomodulin Is Mediated by Dendritic Cells.” 2017. Thesis, Mie University / 三重大学. Accessed March 08, 2021.
http://hdl.handle.net/10076/14732.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Takagi, Takehiro. “Inhibition of Allergic Bronchial Asthma by Thrombomodulin Is Mediated by Dendritic Cells.” 2017. Web. 08 Mar 2021.
Vancouver:
Takagi T. Inhibition of Allergic Bronchial Asthma by Thrombomodulin Is Mediated by Dendritic Cells. [Internet] [Thesis]. Mie University / 三重大学; 2017. [cited 2021 Mar 08].
Available from: http://hdl.handle.net/10076/14732.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Takagi T. Inhibition of Allergic Bronchial Asthma by Thrombomodulin Is Mediated by Dendritic Cells. [Thesis]. Mie University / 三重大学; 2017. Available from: http://hdl.handle.net/10076/14732
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Mississippi State University
25.
Jenkins, Katie Marie.
EVALUATING THE MECHANISM OF OXALATE SYNTHESIS OF FIBROPORIA RADICULOSA ISOLATES ADAPTING TO COPPER-TOLERANCE.
Degree: MS, Forest Products, 2012, Mississippi State University
URL: http://sun.library.msstate.edu/ETD-db/theses/available/etd-04022012-100258/
;
► Four <i>Fibroporia radiculosa</i> isolates undergoing decay of untreated and 1.2% ammoniacal copper citrate treated wood were evaluated for differential expression of citrate synthase (CS),…
(more)
▼ Four <i>Fibroporia radiculosa</i> isolates undergoing decay of untreated and 1.2% ammoniacal copper citrate treated wood were evaluated for differential expression of citrate synthase (CS), isocitrate lyase (ICL), glyoxylate dehydrogenase (GLOXDH), succinate/fumarate antiporter (ANTI), and a copper resistance-associated ATPase pump (ATPase). Samples were analyzed at 2, 4, 6, and 8 weeks for oxalate and protein production, enzyme activities, and gene expression. ATPase pump expression was increased in the presence of copper when initial oxalate concentrations were low, suggesting it functions in helping the fungus adapt to the copper-rich environment by pumping toxic copper ions out of the cell. A connection in expression levels between CS, ANTI, ICL, and GLOXDH for the four isolates was found suggesting the production of oxalate originates in the mictochondrial TCA cycle (CS), shunts to the glyoxysomal glyoxylate cycle (ANTI), moves through a portion of the glyoxylate cycle (ICL), and ultimately is made in the cytoplasm (GLOXDH).
Advisors/Committee Members: Susan V. Diehl (chair), M. Lynn Prewitt (committee member), Kenneth O. Willeford (committee member), Carol A. Clausen (committee member), Fredrick Green III (committee member).
Subjects/Keywords: oxlate; copper-tolerance; Fibroporia radiculosa
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Jenkins, K. M. (2012). EVALUATING THE MECHANISM OF OXALATE SYNTHESIS OF FIBROPORIA RADICULOSA ISOLATES ADAPTING TO COPPER-TOLERANCE. (Masters Thesis). Mississippi State University. Retrieved from http://sun.library.msstate.edu/ETD-db/theses/available/etd-04022012-100258/ ;
Chicago Manual of Style (16th Edition):
Jenkins, Katie Marie. “EVALUATING THE MECHANISM OF OXALATE SYNTHESIS OF FIBROPORIA RADICULOSA ISOLATES ADAPTING TO COPPER-TOLERANCE.” 2012. Masters Thesis, Mississippi State University. Accessed March 08, 2021.
http://sun.library.msstate.edu/ETD-db/theses/available/etd-04022012-100258/ ;.
MLA Handbook (7th Edition):
Jenkins, Katie Marie. “EVALUATING THE MECHANISM OF OXALATE SYNTHESIS OF FIBROPORIA RADICULOSA ISOLATES ADAPTING TO COPPER-TOLERANCE.” 2012. Web. 08 Mar 2021.
Vancouver:
Jenkins KM. EVALUATING THE MECHANISM OF OXALATE SYNTHESIS OF FIBROPORIA RADICULOSA ISOLATES ADAPTING TO COPPER-TOLERANCE. [Internet] [Masters thesis]. Mississippi State University; 2012. [cited 2021 Mar 08].
Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-04022012-100258/ ;.
Council of Science Editors:
Jenkins KM. EVALUATING THE MECHANISM OF OXALATE SYNTHESIS OF FIBROPORIA RADICULOSA ISOLATES ADAPTING TO COPPER-TOLERANCE. [Masters Thesis]. Mississippi State University; 2012. Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-04022012-100258/ ;
University of Alberta
26.
Thangavelu, Govindarajan.
Pivotal role of co-inhibitory molecules in immune
tolerance.
Degree: PhD, Department of Surgery, 2011, University of Alberta
URL: https://era.library.ualberta.ca/files/bv73c0666
► The main function of co-inhibitory molecules is to regulate T cell immune responses by providing negative signals to those cells. Homeostatic activation of T cells…
(more)
▼ The main function of co-inhibitory molecules is to
regulate T cell immune responses by providing negative signals to
those cells. Homeostatic activation of T cells occurs in both
natural and artificially induced states of lymphopenia. Although
lymphopenia leads to homeostatic proliferation of T cells, it does
not always lead to autoimmunity, suggesting that control mechanisms
may exist. Controlling these mechanisms may be particularly
important during the period when the first T cells are exported
from the thymus, as many recent thymic emigrants (RTE) have not yet
had the opportunity to undergo peripheral tolerance. In chapters 2
and 3, I tested whether the major function of the co-inhibitory
receptors such as programmed death-1 (PD-1) and B and T cell
attenuator (BTLA) is to control autoimmunity induced by homeostatic
activation, and also to assess their importance in RTE vs.
established peripheral T cells. Interestingly, I found that their
function is more critical only in newly generated T cells but not
in mature T cells as PD-1-/- or BTLA -/- RTE induced a lethal
multi-organ inflammatory disease in lymphopenic recipients. The
disease induced by lymphopenia induced proliferation (LIP) was
inhibited by reducing lymphoid space and also by providing
polyclonal T cells as competitors for the pathogenic T cells. In
chapter 4, I examined whether co-inhibitory molecules play a
critical role in the "spontaneous" allograft tolerance of male
islets. Among those tested, only PD-1 has a role in spontaneous
acceptance of male islet allografts. While T cells have been
observed to induce bystander killing of uninfected cells at the
vicinity of the infected cells during viral infections in vitro,
very little is known about the existence of bystander killing in
vivo and also the mechanisms that limit this type of killing. In
chapter 5, I investigated the capacity for bystander killing of
islet cells in vivo and observed that PD-1, but not BTLA, can limit
bystander killing. Overall, my studies have divulged the critical
roles of co-inhibitory molecules in the maintenance of
self-tolerance and these research findings will provide critical
insights in the development of novel therapies to combat
autoimmunity and rejection of transplants.
Subjects/Keywords: Tolerance; Programmed Death-1; Autoimmunity
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Thangavelu, G. (2011). Pivotal role of co-inhibitory molecules in immune
tolerance. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/bv73c0666
Chicago Manual of Style (16th Edition):
Thangavelu, Govindarajan. “Pivotal role of co-inhibitory molecules in immune
tolerance.” 2011. Doctoral Dissertation, University of Alberta. Accessed March 08, 2021.
https://era.library.ualberta.ca/files/bv73c0666.
MLA Handbook (7th Edition):
Thangavelu, Govindarajan. “Pivotal role of co-inhibitory molecules in immune
tolerance.” 2011. Web. 08 Mar 2021.
Vancouver:
Thangavelu G. Pivotal role of co-inhibitory molecules in immune
tolerance. [Internet] [Doctoral dissertation]. University of Alberta; 2011. [cited 2021 Mar 08].
Available from: https://era.library.ualberta.ca/files/bv73c0666.
Council of Science Editors:
Thangavelu G. Pivotal role of co-inhibitory molecules in immune
tolerance. [Doctoral Dissertation]. University of Alberta; 2011. Available from: https://era.library.ualberta.ca/files/bv73c0666
University of Alberta
27.
Chen, Xue.
Molecular and functional characterization of
sn-glycerol-3-phosphate acyltransferase of plants.
Degree: PhD, Department of Agricultural, Food and Nutritional
Science, 2011, University of Alberta
URL: https://era.library.ualberta.ca/files/1c18dh23g
► sn-Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the acylation of sn-1 position of sn-glycerol-3-phosphate to produce lysophosphatidic acid and Coenzyme A. GPATs are involved in several lipid synthetic…
(more)
▼ sn-Glycerol-3-phosphate acyltransferase (GPAT)
catalyzes the acylation of sn-1 position of sn-glycerol-3-phosphate
to produce lysophosphatidic acid and Coenzyme A. GPATs are involved
in several lipid synthetic pathways and play important
physiological roles in plant development. The present doctoral
thesis includes three related studies, which aim to molecularly and
functionally characterize several plant GPAT genes and the encoded
enzymes. The first study characterized three endoplasmic
reticulum-bound GPAT4s encoded by three homologous GPAT4 genes of
Brassica napus (oilseed rape), focusing primarily on their
functional divergence and physiological roles in plant development
and lipid biosynthesis. The three homologous GPAT4 genes exhibited
different expression patterns and altered epigenetic features.
Phenotypic rescue of a gpat4 gpat8 Arabidopsis double mutant and
analysis of the gpat4 RNAi B. napus lines suggested physiological
roles for the GPAT4s in cuticle formation of the rosette leaves,
early flower development, pollen development and storage lipid
biosynthesis. The second study investigated stable internal
reference genes for gene expression studies in B. napus. This
project identified four reliable reference genes to be used in gene
expression analysis of BnGPAT4 homologues in both vegetative
tissues and developing seeds. The third study focused on molecular
cloning and biochemical characterization of a soluble plastidial
GPAT isolated from a chilling-tolerant plant, western wallflower
(Erysimum asperum). A truncated form of recombinant EaGPAT, with
the putative transit peptide deleted, was functionally expressed in
yeast. A series of enzymatic assays were performed in order to
determine the optimum in vitro reaction conditions for the
recombinant EaGPAT. The recombinant EaGPAT was further assayed with
different acyl-CoAs and exhibited a substrate preference for 18
carbon unsaturated acyl-CoAs. With this substrate preference, the
EaGPAT could potentially be used as a biotechnological tool for
improving plant chilling-tolerance or increasing unsaturated fatty
acid content of seed oil. Overall, the present doctoral studies
revealed the functional divergence and important physiological
roles of the GPAT4s in B. napus, and biochemically characterized a
plastidial GPAT from E. asperum. The knowledge obtained from these
studies provides new insights into the role of GPAT in plants and
will be useful for further development of biotechnological
approaches to modify seed oil biosynthesis in oleaginous
crops.
Subjects/Keywords: Brassica napus; chilling-tolerance; GPAT
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Chen, X. (2011). Molecular and functional characterization of
sn-glycerol-3-phosphate acyltransferase of plants. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/1c18dh23g
Chicago Manual of Style (16th Edition):
Chen, Xue. “Molecular and functional characterization of
sn-glycerol-3-phosphate acyltransferase of plants.” 2011. Doctoral Dissertation, University of Alberta. Accessed March 08, 2021.
https://era.library.ualberta.ca/files/1c18dh23g.
MLA Handbook (7th Edition):
Chen, Xue. “Molecular and functional characterization of
sn-glycerol-3-phosphate acyltransferase of plants.” 2011. Web. 08 Mar 2021.
Vancouver:
Chen X. Molecular and functional characterization of
sn-glycerol-3-phosphate acyltransferase of plants. [Internet] [Doctoral dissertation]. University of Alberta; 2011. [cited 2021 Mar 08].
Available from: https://era.library.ualberta.ca/files/1c18dh23g.
Council of Science Editors:
Chen X. Molecular and functional characterization of
sn-glycerol-3-phosphate acyltransferase of plants. [Doctoral Dissertation]. University of Alberta; 2011. Available from: https://era.library.ualberta.ca/files/1c18dh23g
28.
佐伯, 晃一.
THEORETICAL STUDIES OF SELF-TOLERANCE : REGULATORY T CELLS AND ANERGY : 自己寛容に関する理論的研究 : 制御性Ｔ細胞とアナジーについて.
Degree: 博士（理学）, 2013, Kyushu University / 九州大学
URL: http://hdl.handle.net/2324/21712
;
http://dx.doi.org/10.15017/21712
自己寛容とは免疫システムが自分の体に対して反応を示さない状態のことである。これは生物が生まれながらに持っている性質ではなく、成立にはその為のメカニズムが必要である。例えば、獲得免疫系を担うリンパ球はランダムに生成された受容体を用いて抗原の認識を行うため、自分の体由来の抗原を認識するリンパ球も作られる。そのため成熟前に受容体をチェックし、自己抗原を認識するものは排除する(負の選択)機構が存在する。しかしながら、このチェック機構だけでは不十分であり、リンパ球の成熟後に末梢において自己寛容を保証するメカニズムがあることが知られている。自己寛容の破綻は自己免疫疾患につながるため、メカニズムの理解は医学的な観点からも注目を集めている。本論文では、自己寛容の成立に関わっている二つの機構、制御性T細胞とアナジーに着目しそれらの意義ついて数理モデルを用いて議論した。二つの機構は常に有益となるわけではなく、幾つかの条件下で有利に働くことが分かった。
Advisors/Committee Members: 巌佐, 庸.Subjects/Keywords: self-tolerance; regulatory T cells
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APA (6th Edition):
佐伯, . (2013). THEORETICAL STUDIES OF SELF-TOLERANCE : REGULATORY T CELLS AND ANERGY : 自己寛容に関する理論的研究 : 制御性Ｔ細胞とアナジーについて. (Thesis). Kyushu University / 九州大学. Retrieved from http://hdl.handle.net/2324/21712 ; http://dx.doi.org/10.15017/21712
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
佐伯, 晃一. “THEORETICAL STUDIES OF SELF-TOLERANCE : REGULATORY T CELLS AND ANERGY : 自己寛容に関する理論的研究 : 制御性Ｔ細胞とアナジーについて.” 2013. Thesis, Kyushu University / 九州大学. Accessed March 08, 2021.
http://hdl.handle.net/2324/21712 ; http://dx.doi.org/10.15017/21712.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
佐伯, 晃一. “THEORETICAL STUDIES OF SELF-TOLERANCE : REGULATORY T CELLS AND ANERGY : 自己寛容に関する理論的研究 : 制御性Ｔ細胞とアナジーについて.” 2013. Web. 08 Mar 2021.
Vancouver:
佐伯 . THEORETICAL STUDIES OF SELF-TOLERANCE : REGULATORY T CELLS AND ANERGY : 自己寛容に関する理論的研究 : 制御性Ｔ細胞とアナジーについて. [Internet] [Thesis]. Kyushu University / 九州大学; 2013. [cited 2021 Mar 08].
Available from: http://hdl.handle.net/2324/21712 ; http://dx.doi.org/10.15017/21712.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
佐伯 . THEORETICAL STUDIES OF SELF-TOLERANCE : REGULATORY T CELLS AND ANERGY : 自己寛容に関する理論的研究 : 制御性Ｔ細胞とアナジーについて. [Thesis]. Kyushu University / 九州大学; 2013. Available from: http://hdl.handle.net/2324/21712 ; http://dx.doi.org/10.15017/21712
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Cornell University
29.
Arbelaez Velez, Juan.
Exploring And Dissecting The Genetic Basis Of Al Tolerance In Rice (Oryza Sativa L.).
Degree: PhD, Plant Breeding, 2015, Cornell University
URL: http://hdl.handle.net/1813/40645
► Aluminum (Al) toxicity is a major stress factor limiting agricultural production on highly acidic soils. These types of soils, with pH values [LESS-THAN OR EQUAL…
(more)
▼ Aluminum (Al) toxicity is a major stress factor limiting agricultural production on highly acidic soils. These types of soils, with pH values [LESS-THAN OR EQUAL TO] 5.0, are distributed over 70% of the world's potentially arable land. Rice (O. sativa L.) is one of the most Al tolerant species among smallgrain cereals, and within rice, cultivars from the varietal group Japonica are more tolerant than the Indica cultivar types. The genetic architecture of Al tolerance in rice is complex involving several genes and physiological mechanisms. To explore the natural genetic variation of Al tolerance in rice we developed 4 sets of reciprocal near isogenic lines (NILs), each targeting one of four loci associated with Al tolerance on chromosomes 1, 2, 9, and 12 from a cross between the Al susceptible indica cultivar, IR64, and the Al tolerant tropical japonica cultivar, Azucena. Phenotypic evaluation for Al tolerance in the NILs validated the effects of the QTLs on chromosomes 1, 9, and 12. We further explored the genetic basis of Al tolerance at the QTL on chromosome 12 by implementing a recombinant fine-mapping approach and narrowed down the target region to a ~44 Kb locus that contained 6 predicted genes, including ART1, a transcription factor known to regulate the expression of 31 genes in an Al-dependent manner, many of them involved in different Al tolerance mechanisms. These newly developed NILs, and two sets of interspecific introgression lines (ILs), constructed using two wild accessions as donors, O. rufipogon Griff., and O. meridionalis Ng., and a common recurrent parent, cv. Curinga (O. sativa ssp. tropical japonica), represent valuable germplasm resources for understanding the genetic basis of Al tolerance in rice. They can be used as parental materials for fine mapping and positional cloning efforts and as the basis for detailed molecular physiology studies. This work is also the first effort to confirm whether ART1, our strongest candidate gene in the 44 Kb region, is responsible for the Al tolerance effect of the QTL on chromosome 12.
Subjects/Keywords: Rice; Oryza sativa; Al tolerance
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APA (6th Edition):
Arbelaez Velez, J. (2015). Exploring And Dissecting The Genetic Basis Of Al Tolerance In Rice (Oryza Sativa L.). (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/40645
Chicago Manual of Style (16th Edition):
Arbelaez Velez, Juan. “Exploring And Dissecting The Genetic Basis Of Al Tolerance In Rice (Oryza Sativa L.).” 2015. Doctoral Dissertation, Cornell University. Accessed March 08, 2021.
http://hdl.handle.net/1813/40645.
MLA Handbook (7th Edition):
Arbelaez Velez, Juan. “Exploring And Dissecting The Genetic Basis Of Al Tolerance In Rice (Oryza Sativa L.).” 2015. Web. 08 Mar 2021.
Vancouver:
Arbelaez Velez J. Exploring And Dissecting The Genetic Basis Of Al Tolerance In Rice (Oryza Sativa L.). [Internet] [Doctoral dissertation]. Cornell University; 2015. [cited 2021 Mar 08].
Available from: http://hdl.handle.net/1813/40645.
Council of Science Editors:
Arbelaez Velez J. Exploring And Dissecting The Genetic Basis Of Al Tolerance In Rice (Oryza Sativa L.). [Doctoral Dissertation]. Cornell University; 2015. Available from: http://hdl.handle.net/1813/40645
Cornell University
30.
Song, Yeejiun.
Toward Robust High Performance Distributed Services.
Degree: PhD, Computer Science, 2011, Cornell University
URL: http://hdl.handle.net/1813/30741
► This thesis presents steps towards simplifying the implementation of robust high performance distributed services. First, we investigate consensus algorithms in the context of fault tolerant…
(more)
▼ This thesis presents steps towards simplifying the implementation of robust high performance distributed services. First, we investigate consensus algorithms in the context of fault tolerant systems. Consensus algorithms, often a critical part of fault tolerant systems, are notoriously difficult to implement. We present a skeleton consensus algorithm that can be instantiated into several well-known consensus protocols, providing insight into the structure of consensus algorithms as well as the differences and performance tradeoffs between different algorithms. We investigate onestep Byzantine agreement algorithms which exploit contention-free situations to provide low latency performance. We present definitions of one-step algorithms and prove a lower bound on the number of processors required for such algorithms, thereby showing that our algorithm is optimal. We then generalize our investigation to k-set agreement. Second, we present RPC chains, a communication primitive that improves the performance of geodistributed enterprise applications. Distributed enterprise applications are often built as a composition of more basic services. Currently, such compositions are built using remote procedure calls (RPCs). This results in a rigid and inefficient communication pattern. RPC chains is a new ion that applies two well-known ideas, function shipping and continuations, to allow an improvement in the latency performance and reduction in the overall bandwidth usage of such geodistributed systems.
Advisors/Committee Members: Van Renesse, Robbert (chair), Huttenlocher, Daniel Peter (committee member), Halpern, Joseph Yehuda (committee member).
Subjects/Keywords: Distributed systems; Consensus; Fault tolerance
Record Details
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Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Song, Y. (2011). Toward Robust High Performance Distributed Services. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/30741
Chicago Manual of Style (16th Edition):
Song, Yeejiun. “Toward Robust High Performance Distributed Services.” 2011. Doctoral Dissertation, Cornell University. Accessed March 08, 2021.
http://hdl.handle.net/1813/30741.
MLA Handbook (7th Edition):
Song, Yeejiun. “Toward Robust High Performance Distributed Services.” 2011. Web. 08 Mar 2021.
Vancouver:
Song Y. Toward Robust High Performance Distributed Services. [Internet] [Doctoral dissertation]. Cornell University; 2011. [cited 2021 Mar 08].
Available from: http://hdl.handle.net/1813/30741.
Council of Science Editors:
Song Y. Toward Robust High Performance Distributed Services. [Doctoral Dissertation]. Cornell University; 2011. Available from: http://hdl.handle.net/1813/30741
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