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Boston University
1.
Vrolyk, Michael.
Testosterone replacement therapy.
Degree: MS, Medical Sciences, 2015, Boston University
URL: http://hdl.handle.net/2144/16024
► Physicians and scientists have suspected that the testes secrete a substance into the body that causes male secondary sexual characteristics for hundreds of years. However,…
(more)
▼ Physicians and scientists have suspected that the testes secrete a substance into the body that causes male secondary sexual characteristics for hundreds of years. However, testosterone was not synthesized until 1935 and it was not until the 1940's when scientists could accurately measure the amount of this hormone in the blood. Since then, scientists have been able to make correlations between the levels of testosterone in the body and men's health
Scientists have long observed higher levels of testosterone to be associated with an increase in levels of Hematocrit (Hct). As a result, Testosterone Replacement Therapy (TRT) has been used to treat anemia associated with chronic diseases. In recent years, prescription sales for testosterone have sky rocketed due to new clinical uses such as androgen deficiency in older men. In fact, the rate of prescription for testosterone products has increased by over 170% in the previous five years.
Long-term data shows that the level of testosterone in the male body begins to decrease at about the age of 30. As the life expectancy of the general population continues to increase, TRT may be a viable option for older men with low testosterone to increase the quality and duration of life. However, an increase in Hct continues to be a major side effect of TRT. New research is beginning to make clear the mechanism by which testosterone affects erythropoeisis.
New research suggests TRT suppresses hepcidin and leads to an increase in the rate of iron (Fe) retention in red blood cells (RBCs). Inter-individual differences in the pharmacogenetic effects of TRT have been observed. In the future TRT could be genetically tailored based on the individuals DNA. In this case, the optimal dose of testosterone can be given to maximize benefits and reduce side effects.
Here, the risks and benefits associated with TRT and a review of the updated Clinical Guidelines for its use will be presented. The effects of TRT on erythropoeisis will be investigated via a review of the literature. The main objective of this review is to provide a general understanding of TRT and a major side effect of its use, excessive erythropoeisis.
Subjects/Keywords: Endocrinology; Testosterone
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APA (6th Edition):
Vrolyk, M. (2015). Testosterone replacement therapy. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/16024
Chicago Manual of Style (16th Edition):
Vrolyk, Michael. “Testosterone replacement therapy.” 2015. Masters Thesis, Boston University. Accessed February 27, 2021.
http://hdl.handle.net/2144/16024.
MLA Handbook (7th Edition):
Vrolyk, Michael. “Testosterone replacement therapy.” 2015. Web. 27 Feb 2021.
Vancouver:
Vrolyk M. Testosterone replacement therapy. [Internet] [Masters thesis]. Boston University; 2015. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/2144/16024.
Council of Science Editors:
Vrolyk M. Testosterone replacement therapy. [Masters Thesis]. Boston University; 2015. Available from: http://hdl.handle.net/2144/16024

Oregon State University
2.
Heitz, David Carl.
Some effects of testosterone on cichlid fish, Cichlosoma bimaculatum (Linnaeus).
Degree: MS, Pharmacology, 1967, Oregon State University
URL: http://hdl.handle.net/1957/6742
► The effects of testosterone were studied on the tropical fish, Cichlasoma bimaculatum. Growth experiments were designed to determine how testosterone influenced the food consumption and…
(more)
▼ The effects of testosterone were studied on the tropical fish, Cichlasoma bimaculatum. Growth experiments were designed to determine how testosterone influenced the food consumption and growth of fish. Starvation experiments were designed to show the effects of testosterone on the basal rate of utilization of body energy stores and to establish what effect the anabolic steroid has when anabolism is reduced by the absence of metabolites from food. During the course of the experiments data were collected on
wet weight, dry weight, fat, ash, protein and water content and on heat of combustion for control and testosterone treated fish. Four experiments were conducted where cichlids were starved, some as controls and some continuously exposed to testosterone 1:1,000,000. Wet weight, dry weight, weight of crude fat, weight of ash and the water content per cichlid usually decreased during
starvation in controls and in the cichlids exposed to testosterone. Water content varied irregularly with reference to protein. Protein usually dropped where as water content dropped clearly in only one control experiment, did not alter markedly in two and increased in one. The testosterone treated fish tended to accumulate more water than did controls. Considerable variability was noted in the data. Much was due to an uneven distribution of cichlids with respect to weight among various groups and subgroups. Despite precautionary measures it was very difficult to maintain true starvation conditions. Some nonfilterable organic materials in the water as well as algae and minute insects may have been a source of food to the starving fish. More evident however, was the food made available as the result of the death of fish. On several occasions there was evidence of cannibalism, both in control and testosterone treated groups. The death
of a fish, besides affording food to starving cichlids, introduced an error in the direction of increasing the average if a small fish died, and of decreasing the average if a Larger fish died. On the basis of calories disappearing during starvation, it was shown that starvation and starvation plus testosterone altered the composition of cichlids and decreased the heat of combustion per gram of cichlid. The testosterone treated fish were usually altered to a greater extent. Two growth studies were conducted where some cichlids were fed essentially ad libitum and utilized as controls, and others fed and continuously exposed to testosterone 1: 1, 000, 000. Dry weight in four out of six available comparisons was lower in testosterone treated fish than in controls; in one case the dry weights were similar and in one case the control cichlids had the higher dry weight. Protein was lower in five out of six available comparisons in the testosterone treated fish and were similar in one comparison. The control cichlids fed tubificids accumulated higher amounts of fat
than cichlids fed and exposed to testosterone. The amount of food consumed per testosterone treated fish at each sample period was less than for the…
Subjects/Keywords: Testosterone
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Heitz, D. C. (1967). Some effects of testosterone on cichlid fish, Cichlosoma bimaculatum (Linnaeus). (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/6742
Chicago Manual of Style (16th Edition):
Heitz, David Carl. “Some effects of testosterone on cichlid fish, Cichlosoma bimaculatum (Linnaeus).” 1967. Masters Thesis, Oregon State University. Accessed February 27, 2021.
http://hdl.handle.net/1957/6742.
MLA Handbook (7th Edition):
Heitz, David Carl. “Some effects of testosterone on cichlid fish, Cichlosoma bimaculatum (Linnaeus).” 1967. Web. 27 Feb 2021.
Vancouver:
Heitz DC. Some effects of testosterone on cichlid fish, Cichlosoma bimaculatum (Linnaeus). [Internet] [Masters thesis]. Oregon State University; 1967. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/1957/6742.
Council of Science Editors:
Heitz DC. Some effects of testosterone on cichlid fish, Cichlosoma bimaculatum (Linnaeus). [Masters Thesis]. Oregon State University; 1967. Available from: http://hdl.handle.net/1957/6742

University of Manchester
3.
O'Connell, Matthew.
Frailty and Anabolic Hormones in Ageing Men.
Degree: 2011, University of Manchester
URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:138103
► Frailty can be broadly defined as the vulnerable health status that occurs in older adults. With the ageing population understanding frailty is becoming an increasingly…
(more)
▼ Frailty can be broadly defined as the vulnerable
health status that occurs in older adults. With the ageing
population understanding frailty is becoming an increasingly
important issue. While no consensus exists on the exact definition
of frailty, two models have become prominent in geriatric research.
These are the frailty phenotype, a model that measures frailty
according to the syndromic aggregation of 5 physical criteria and
the frailty index (FI), a broad index of age related health
deficits. While recent years have seen a substantial increase in
research into frailty, there remains a relative paucity of data
from European studies and studies in men. Of the many mechanisms
suggested to contribute to frailty there has been particular
interest in the role of declining levels of anabolic hormones,
partly because replacement of these hormones represents a potential
strategy for managing this condition. The broad aim of this thesis
was to explore the condition of frailty and its relationship to
anabolic hormones, particularly
testosterone (T) in ageing European
Men. This project involved analysis of data from 2 studies: The
European Male Ageing Study (EMAS), a longitudinal cohort study of
3369 men from 8 European centres and a trial of T treatment in 262
men with low
testosterone and symptoms of frailty. A set of
phenotypic frailty criteria were developed for use in the EMAS,
using this model the prevalence of frailty was 2.6%. This increased
with age from 0.1% in men aged 40-49 up to 6.7% in men aged 70-79.
This model was compared against an FI, the correlation between the
two models was moderate, r=0.41, and both models were related to
incident falling at 2 year follow up; Ordinal OR (95% CI), 3.15
(1.75 to 5.66) for the frailty phenotype and 5.28 (3.35 to 8.32)
for the FI in adjusted analyses. In the hormone analyses frailty
was related to lower free T according to both models, Ordinal OR
(95% CI); 1.19 (1.02 to 1.39) for the phenotype and β-coefficient
(95% CI); 0.006 (0.003 to 0.009) for the FI (FI values range from
0-0.7). Free T was particularly related to the sarcopenia criteria
OR (95% CI); 1.40 (1.09 to 1.80). Frailty was also related to LH,
FSH and SHBG. Deficiency in multiple anabolic hormones was related
to frailty, in adjusted analyses each additional deficiency was
associated with an RRR (95% CI); 1.71 (1.38 to 2.13) increased risk
of phenotypic frailty and a β-coefficient (95% CI); 0.016 (0.012 to
0.02) increase in FI score. The trial analyses focussed on a 6
month post treatment follow up phase. It was found that gains in
lean mass and muscle strength were not maintained at 6 months post
treatment. The adjusted difference between groups at 6 months post
treatment for knee extensor strength was 4.0 (-3.9 to 11.9) Nm
compared to 8.1 (-0.2 to 16.5) Nm at the end of treatment,
similarly the difference in lean mass declined from 1.2 (0.8 to
1.7) kg at end of treatment to 0.3 (-0.1 to 0.8) kg at 6 months
post treatment. In summary, the frailty phenotype was adapted and
validated for use in the EMAS study.…
Advisors/Committee Members: ROBERTS, STEPHEN SA, TAJAR, ABDELOUAHID A, Wu, Frederick, Roberts, Stephen, Tajar, Abdelouahid.
Subjects/Keywords: Ageing; Frailty; Testosterone
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
O'Connell, M. (2011). Frailty and Anabolic Hormones in Ageing Men. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:138103
Chicago Manual of Style (16th Edition):
O'Connell, Matthew. “Frailty and Anabolic Hormones in Ageing Men.” 2011. Doctoral Dissertation, University of Manchester. Accessed February 27, 2021.
http://www.manchester.ac.uk/escholar/uk-ac-man-scw:138103.
MLA Handbook (7th Edition):
O'Connell, Matthew. “Frailty and Anabolic Hormones in Ageing Men.” 2011. Web. 27 Feb 2021.
Vancouver:
O'Connell M. Frailty and Anabolic Hormones in Ageing Men. [Internet] [Doctoral dissertation]. University of Manchester; 2011. [cited 2021 Feb 27].
Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:138103.
Council of Science Editors:
O'Connell M. Frailty and Anabolic Hormones in Ageing Men. [Doctoral Dissertation]. University of Manchester; 2011. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:138103

AUT University
4.
Beaven, Christopher Martyn.
Hormone-mediated strategies to enhance training and performance
.
Degree: 2011, AUT University
URL: http://hdl.handle.net/10292/1221
► Rugby union is a highly competitive and physically demanding contact sport in which successful outcomes rely, inherently, on strength, power, speed, and endurance. Resistance training…
(more)
▼ Rugby union is a highly competitive and physically demanding contact sport in which successful outcomes rely, inherently, on strength, power, speed, and endurance. Resistance training is a potent stimulus for skeletal muscle strength and power adaptation, and training stimuli and loads modulate adaptation. Adaptive responses are mediated by cellular and molecular events, and actualised by alterations in gene expression. The steroid hormones
testosterone and cortisol play a role in the adaptive process and subsequent training outcomes. This thesis investigates strategies intended to modify salivary hormone responses and affect resistance training outcomes. A literature review examined the cellular response of skeletal muscle tissue to resistance exercise with attention focussed on how
testosterone and cortisol mediate adaptive outcomes. The acute
testosterone and cortisol responses to complex training were investigated in Chapter Three. Sixteen rugby players performed four exercise protocols in a cross-over manner: power-power; power-strength; strength-power; or strength-strength. The most noteworthy responses were a small
testosterone elevation and a trivial elevation in cortisol following the strength-power protocol, suggesting that this exercise sequence elicited an enhanced anabolic state compared to the other exercise protocols. An interaction between hormonal circadian rhythms and exercise stimulus was investigated in Chapter Four. Eight rugby players performed identical squat training over four weeks either in the morning or in the afternoon. Clear differences were observed between pre- and post-exercise hormone concentrations, and the ratio of
testosterone to cortisol was elevated in the afternoon. Training resulted in similar increases in box squat strength regardless of time performed; however peak power increased to a greater extent when training was performed in the afternoon. This observation suggested that circadian rhythmicity has the potential to modulate specific adaptations to resistance exercise. The effect of the ultradian pulsatility of
testosterone and cortisol, and their interaction with the hormonal responses to physiological and psychological stimuli, were investigated in Chapter Five.
Testosterone and cortisol concentrations of seven males were measured every 10 min between 0800 and 1600 h on three consecutive days. Analysis was consistent with episodic
testosterone pulses on non-intervention days. A sprint intervention elicited a small elevation in
testosterone and this response correlated with the change in
testosterone concentration in the 10 min prior to exercise. Thus, the
testosterone response to exercise may be related to the ultradian biorhythm. This interaction could have important implications for adaptation to exercise. The ability of caffeine to modify the hormonal response to exercise was investigated in Chapter Six. A double-blinded, placebo controlled study with 24 athletes ingesting 0, 200, 400, or 800 mg doses of caffeine, assessed
testosterone and cortisol responses to…
Advisors/Committee Members: Gill, Nicholas (advisor), Ingram, John (advisor), Hopkins, Will (advisor).
Subjects/Keywords: Testosterone;
Cortisol;
Rugby
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Beaven, C. M. (2011). Hormone-mediated strategies to enhance training and performance
. (Thesis). AUT University. Retrieved from http://hdl.handle.net/10292/1221
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Beaven, Christopher Martyn. “Hormone-mediated strategies to enhance training and performance
.” 2011. Thesis, AUT University. Accessed February 27, 2021.
http://hdl.handle.net/10292/1221.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Beaven, Christopher Martyn. “Hormone-mediated strategies to enhance training and performance
.” 2011. Web. 27 Feb 2021.
Vancouver:
Beaven CM. Hormone-mediated strategies to enhance training and performance
. [Internet] [Thesis]. AUT University; 2011. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/10292/1221.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Beaven CM. Hormone-mediated strategies to enhance training and performance
. [Thesis]. AUT University; 2011. Available from: http://hdl.handle.net/10292/1221
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University
5.
Pollock, Nicholas, 1984-.
Androgens and ectoparasites as proximate factors influencing growth in the sexually dimorphic lizard, Sceloporus undulatus.
Degree: PhD, Ecology and Evolution, 2016, Rutgers University
URL: https://rucore.libraries.rutgers.edu/rutgers-lib/51432/
► A growing body of evidence indicates that testosterone (T) plays an important role in regulating patterns of growth in lizards. Testosterone has also been found…
(more)
▼ A growing body of evidence indicates that testosterone (T) plays an important role in regulating patterns of growth in lizards. Testosterone has also been found to facilitate the development of male-typical coloration and a suite of male behaviors that increase reproductive success. However, while T promotes male fitness through these characteristics, it appears to hinder fitness through direct molecular inhibition of growth and through indirect potential costs associated with increased parasitism. The relationship between T and ectoparasitism is complicated by seasonal variation in host circulating T levels and ectoparasite life cycles. It is unclear whether sex differences in ectoparasite loads are present year-round, are present only when circulating T is high in males, or are present only when ectoparasite abundances are high. Furthermore, it is often assumed that because ectoparasites feed by taking nutrients and energy from their hosts, then ectoparasites likely impact host growth. Effects of ectoparasitism on host growth may be particularly high in males if they have greater ectoparasite loads than females. This could indirectly lead to slower male growth and smaller overall male body size. To address the lack of information regarding direct and indirect effects of T on growth, seasonal variation in sex- biased ectoparasite loads, and of the relationship between ectoparasitism and growth, I investigated (1) whether growth inhibition in eastern fence lizards (Sceloporus undulatus) is regulated through androgen or estrogen receptors, (2) seasonal correlations of mite loads with environmental mite abundances, and (3) whether sex differences in growth are correlated with sex differences in mite loads. I found that DHT inhibits male growth in S. undulatus, suggesting that T inhibits growth through direct androgenic molecular regulation. Furthermore, as indicated by the negative correlation between male growth and mite load, I found that T may also inhibit growth in males indirectly through costs associated with increased mite parasitism. Mite loads on S. undulatus varied seasonally, with peak mite loads occurring during months of high environmental mite abundance, coincident with seasonally high circulating T in yearling males and negatively correlated with male growth. This suggests that mites may impose a cost to growth in S. undulatus and contribute to male growth-inhibition, sex-specific growth rates, and the development of sexual size dimorphism (SSD).
Advisors/Committee Members: John-Alder, Henry B (chair), Lockwood, Julie (internal member), Ostfeld, Richard (internal member), Cox, Robert M (outside member).
Subjects/Keywords: Testosterone; Sceloporus undulatus
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Pollock, Nicholas, 1. (2016). Androgens and ectoparasites as proximate factors influencing growth in the sexually dimorphic lizard, Sceloporus undulatus. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/51432/
Chicago Manual of Style (16th Edition):
Pollock, Nicholas, 1984-. “Androgens and ectoparasites as proximate factors influencing growth in the sexually dimorphic lizard, Sceloporus undulatus.” 2016. Doctoral Dissertation, Rutgers University. Accessed February 27, 2021.
https://rucore.libraries.rutgers.edu/rutgers-lib/51432/.
MLA Handbook (7th Edition):
Pollock, Nicholas, 1984-. “Androgens and ectoparasites as proximate factors influencing growth in the sexually dimorphic lizard, Sceloporus undulatus.” 2016. Web. 27 Feb 2021.
Vancouver:
Pollock, Nicholas 1. Androgens and ectoparasites as proximate factors influencing growth in the sexually dimorphic lizard, Sceloporus undulatus. [Internet] [Doctoral dissertation]. Rutgers University; 2016. [cited 2021 Feb 27].
Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/51432/.
Council of Science Editors:
Pollock, Nicholas 1. Androgens and ectoparasites as proximate factors influencing growth in the sexually dimorphic lizard, Sceloporus undulatus. [Doctoral Dissertation]. Rutgers University; 2016. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/51432/

Universiteit Utrecht
6.
Son, V. van.
Sex steroid hormones and Cognition.
Degree: 2012, Universiteit Utrecht
URL: http://dspace.library.uu.nl:8080/handle/1874/237074
► Apart from their obvious role in the regulation of reproductive functions, sex steroid hormones also appear to influence cognition. Estrogen, testosterone and progesterone affect spatial…
(more)
▼ Apart from their obvious role in the regulation of reproductive functions, sex steroid hormones also appear to influence cognition. Estrogen,
testosterone and progesterone affect spatial cognition and non-spatial working memory.
Testosterone supplementation seems to have a beneficial effect on spatial cognition. A curvilinear relationship between
testosterone and performance on spatial tasks has been proposed. The
testosterone to estrogen ratio might also play a role. Estrogen seems to have a detrimental effect on spatial abilities in humans as well as in animals. The effects of progesterone are less clear. Progesterone could modulate the effects of estrogen, but more research is needed to drawn final conclusions. There is not much evidence on sex steroid hormones influencing non-spatial working memory. Effects of sex steroid hormones on spatial cognition were found in many different circumstances. They arise when hormone levels are exogenously elevated and during the endogenous hormonal fluctuations of the menstrual and estrous cycles. Sex steroids affect spatial cognition in both humans and animals. Many of the effects mentioned could arise by adult neurogenesis in the dentate gyrus of the hippocampus. Steroid hormones can enhance the survival of newly formed neurons, thereby affecting spatial cognition. Evolutionary benefits of
testosterone enhancing and estrogen impairing spatial cognition have been proposed. However, correlations between hormone levels and performance are often weak and it remains to be determined how significant they are. Whether results are found, depends on type and duration of hormone treatment, dosage, task, and other nonmnemonic variables. Sex steroid hormone levels can also influence the strategy chosen to solve a task. To conclude: sex steroids have a small effect, but they are just one of many factors that influence cognition.
Advisors/Committee Members: Oosting, R. S..
Subjects/Keywords: Estrogen; progesterone; testosterone; spatial cognition
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Son, V. v. (2012). Sex steroid hormones and Cognition. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/237074
Chicago Manual of Style (16th Edition):
Son, V van. “Sex steroid hormones and Cognition.” 2012. Masters Thesis, Universiteit Utrecht. Accessed February 27, 2021.
http://dspace.library.uu.nl:8080/handle/1874/237074.
MLA Handbook (7th Edition):
Son, V van. “Sex steroid hormones and Cognition.” 2012. Web. 27 Feb 2021.
Vancouver:
Son Vv. Sex steroid hormones and Cognition. [Internet] [Masters thesis]. Universiteit Utrecht; 2012. [cited 2021 Feb 27].
Available from: http://dspace.library.uu.nl:8080/handle/1874/237074.
Council of Science Editors:
Son Vv. Sex steroid hormones and Cognition. [Masters Thesis]. Universiteit Utrecht; 2012. Available from: http://dspace.library.uu.nl:8080/handle/1874/237074

Universidade Estadual de Campinas
7.
Hopp, Renato Nicolás, 1984-.
Correlação entre a proporção 2D:4De o desempenho acadêmico em alunos de odontologia: Correlation between 2D:4D and academic performance in dentistry students.
Degree: 2012, Universidade Estadual de Campinas
URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/289240
► Abstract: It has been suggested that prenatal testosterone (PT) is positively related to intelligence or learning-ability skills. Digit ratio (2D:4D) is a negative correlate of…
(more)
▼ Abstract: It has been suggested that prenatal
testosterone (PT) is positively related to intelligence or learning-ability skills. Digit ratio (2D:4D) is a negative correlate of PT. This study considered the correlations between 2D:4D and academic success in practical and theoretical disciplines in the Dental School curriculum of the Piracicaba Dental School, State University of Campinas, Brazil. Overall, 80 subjects (40 males and 40 females) aged between 18 and 22 years (means 19.5 ± 1.1 and 19.7 ± 1.2, respectively) had their right hand palm photographed by a digital camera attached to a standardising device, perpendicular to the surface. The images were transferred to a computer and the index and ring fingers were measured from the ventralmost crease up to the tip of the finger using Adobe Photoshop. Data were analyzed using Microsoft Excel and SPSS 16. Mean digit ratio was 0.980 ± 0.038 for males and 0.991 ± 0.025 for females. Digit ratio was correlated to the grades obtained by the students through their first four semesters. Theoretical and practical grades were significantly negatively correlated to digit ratio in males (and this was particularly so after the influence of age and hours of study were removed, p = 0.02 and 0.004, respectively), but not in females (p = 0.89 and 0.77, respectively). This finding supports a link between high PT and intelligence in males. The lack of relationship between 2D:4D and examination marks in female students, suggests that intelligence in females may be influenced by factors other than prenatal
testosterone
Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Jorge Junior, Jacks, 1962- (advisor), Universidade Estadual de Campinas. Faculdade de Odontologia de Piracicaba (institution), Programa de Pós-Graduação em Estomatopatologia (nameofprogram), Zecchin, Karina Gottardello (committee member), Brandini, Daniela Atili (committee member), Shcaira, Vanessa Rocha Lima (committee member), Carvalho, Marco Antonio (committee member).
Subjects/Keywords: Educação; Testosterona; Education; Testosterone
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Hopp, Renato Nicolás, 1. (2012). Correlação entre a proporção 2D:4De o desempenho acadêmico em alunos de odontologia: Correlation between 2D:4D and academic performance in dentistry students. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/289240
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hopp, Renato Nicolás, 1984-. “Correlação entre a proporção 2D:4De o desempenho acadêmico em alunos de odontologia: Correlation between 2D:4D and academic performance in dentistry students.” 2012. Thesis, Universidade Estadual de Campinas. Accessed February 27, 2021.
http://repositorio.unicamp.br/jspui/handle/REPOSIP/289240.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hopp, Renato Nicolás, 1984-. “Correlação entre a proporção 2D:4De o desempenho acadêmico em alunos de odontologia: Correlation between 2D:4D and academic performance in dentistry students.” 2012. Web. 27 Feb 2021.
Vancouver:
Hopp, Renato Nicolás 1. Correlação entre a proporção 2D:4De o desempenho acadêmico em alunos de odontologia: Correlation between 2D:4D and academic performance in dentistry students. [Internet] [Thesis]. Universidade Estadual de Campinas; 2012. [cited 2021 Feb 27].
Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/289240.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hopp, Renato Nicolás 1. Correlação entre a proporção 2D:4De o desempenho acadêmico em alunos de odontologia: Correlation between 2D:4D and academic performance in dentistry students. [Thesis]. Universidade Estadual de Campinas; 2012. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/289240
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Georgia
8.
Stevens, Brittany McKinnon.
Reproductive assessment of two genetic strains of broiler breeder males reared on four different feed intake regimens.
Degree: 2014, University of Georgia
URL: http://hdl.handle.net/10724/26798
► The reproductive development of 2 meat strains (Cobb 500 and Cobb MX) of broiler breeder males provided different levels of total feed intake during rearing…
(more)
▼ The reproductive development of 2 meat strains (Cobb 500 and Cobb MX) of broiler breeder males provided different levels of total feed intake during rearing was evaluated. Six hundred day old cockerels from each strain were divided among 4
feeding treatments (full fed; and concave, standard, and convex restricted feed levels) with each treatment and strain housed separately. The concave and convex feeding treatments were 5-10% above and below standard strain guidelines. All cockerels were
full fed to 3 weeks of age, with the 3 feed restricted treatments implemented at 22 days and continued to 20 weeks of age. At 21 weeks of age 44 cockerels from each restricted feeding treatment and strain were moved to individual cages, photostimulated
and fed to maintain target body weight. Total testes weight relative to total body weight was greater in the full fed cockerels than the restricted fed birds after 8 weeks of age. There were no differences in relative testes weight between any of the
feed restricted birds. For the entire rearing period, the overall relative testes size was greater for the MX males. Regardless of the feeding regimen total testosterone concentrations reached detectable levels 2 to 4 weeks earlier in the MX males than
the Cobb 500 males. The ontogeny of detectable plasma testosterone levels was also negatively correlated with total feed intake. The results suggest that sexual maturation in the MX strain may occur at a faster rate than in the Cobb 500
strain.
Subjects/Keywords: Testosterone; testes development; inhibin
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APA ·
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MLA ·
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CSE |
Export
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APA (6th Edition):
Stevens, B. M. (2014). Reproductive assessment of two genetic strains of broiler breeder males reared on four different feed intake regimens. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/26798
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Stevens, Brittany McKinnon. “Reproductive assessment of two genetic strains of broiler breeder males reared on four different feed intake regimens.” 2014. Thesis, University of Georgia. Accessed February 27, 2021.
http://hdl.handle.net/10724/26798.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Stevens, Brittany McKinnon. “Reproductive assessment of two genetic strains of broiler breeder males reared on four different feed intake regimens.” 2014. Web. 27 Feb 2021.
Vancouver:
Stevens BM. Reproductive assessment of two genetic strains of broiler breeder males reared on four different feed intake regimens. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/10724/26798.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Stevens BM. Reproductive assessment of two genetic strains of broiler breeder males reared on four different feed intake regimens. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/26798
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Boston University
9.
Vance, Jay.
Overselling hysteria, dangerously: the media coverage of testosterone therapy in men.
Degree: MS, Medical Sciences, 2015, Boston University
URL: http://hdl.handle.net/2144/16342
► Testosterone has been used therapeutically for over 70 years in men suffering from the symptoms of testosterone deficiency (TD, hypogonadism), and a strong body of…
(more)
▼ Testosterone has been used therapeutically for over 70 years in men
suffering from the symptoms of testosterone deficiency (TD, hypogonadism), and
a strong body of evidence suggests testosterone treatment is safe and
efficacious in patients for whom it is indicated. Additionally, there exists sufficient
data to recognize male hypogonadism as a risk factor for cardiovascular disease.
Four recently published studies suggested that testosterone therapy is
associated with myocardial infarction, stroke, and death. Although these studies
are afflicted with poor study design, flawed data analysis and misinterpretations,
and received nearly unanimous rejection by experts in the field, the mainstream
media has catapulted the studies into the public spotlight with sensationalist
headlines, creating a hysteria that has had far-reaching and dangerous
implications for patients and physicians. The media-driven hysteria has created
an environment in which pharmaceutical companies are being sued, physicians
are withholding treatment from men suffering from testosterone deficiency, and
the United States Food and Drug Administration has been petitioned to place a
black box warning on testosterone products. The imbalanced media coverage
has crossed a grave ethical line by interfering in the patient-physician relationship
to the extent that patients are being harmed.
Subjects/Keywords: Endocrinology; Hypogonadism; Media; Testosterone
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Vance, J. (2015). Overselling hysteria, dangerously: the media coverage of testosterone therapy in men. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/16342
Chicago Manual of Style (16th Edition):
Vance, Jay. “Overselling hysteria, dangerously: the media coverage of testosterone therapy in men.” 2015. Masters Thesis, Boston University. Accessed February 27, 2021.
http://hdl.handle.net/2144/16342.
MLA Handbook (7th Edition):
Vance, Jay. “Overselling hysteria, dangerously: the media coverage of testosterone therapy in men.” 2015. Web. 27 Feb 2021.
Vancouver:
Vance J. Overselling hysteria, dangerously: the media coverage of testosterone therapy in men. [Internet] [Masters thesis]. Boston University; 2015. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/2144/16342.
Council of Science Editors:
Vance J. Overselling hysteria, dangerously: the media coverage of testosterone therapy in men. [Masters Thesis]. Boston University; 2015. Available from: http://hdl.handle.net/2144/16342
10.
최, 정우.
Testosterone might be influenced by co-morbidities, not by aging.
Degree: 2014, Ajou University
URL: http://repository.ajou.ac.kr/handle/201003/10905
;
http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000016039
► BACKGROUND: Total testosterone in men decreasing with age is well-established. However, observations on aging-related decrease in total testosterone (TT) are not consistent. The aim of…
(more)
▼ BACKGROUND: Total testosterone in men decreasing with age is well-established. However, observations on aging-related decrease in total testosterone (TT) are not consistent. The aim of this study is to seek the relationship between testosterone and health status and investigate the influence of the chronic disease to testosterone level.
METHODS: A total of 4,284 aged ≥ 40 year old men were included between 2008 and 2013. The subjects divided to two groups (chronic disease group versus normal group). Blood tests results and clinical data, including serum total testosterone, were checked and compared between the groups.
RESULTS: Our data showed that 2,041 subjects had chronic diseases (47.6%), and 2,243 were normal (52.4%). Total testosterone and age(r=0.032, P=0.034), HDL(r=0.133, P<0.001) had positive correlation, respectively. On the other hand, BMI(r=-0.198, P<0.001), waist circumference(r=-0.184, P<0.001), blood pressure, ALT(r=-0.132, P<0.001), fasting sugar(r=-0.105, P<0.001), Triglyceride(r=-0.119, P<0.001) and albumin(r=-0.108, P<0.001) showed negative correlation with total testosterone, respectively. Total testosterone level did not decrease with age. People who had metabolic syndrome, hypertension and diabetes were had lower total testosterone than normal population. Odds ratio of the hypogonadism in chronic disease group compared to normal group was 1.595(95% CI, 1.355-1.876, P<0.001).
CONCLUSION: The total testosterone level was lower in chronic disease group compared to healthy subjects. Total testosterone level influenced by disease status, not by aging.
1) 연구배경: 일반적으로 테스토스테론은 나이가 들수록 감소한다고 알려져 있다. 하지만 최근의 연구에 따르면 테스토스테론의 감소 및 남성갱년기는 노화와의 연관성 보다는 만성질환을 포함한 다른 조건에 의할 것이라고 조심스럽게 언급되고 있다. 그러므로 본 연구는 남성호르몬에 영향을 주는 주요 인자 중 질환에 의한 영향을 알아보고자 한다.
2) 방법: 2008년부터 2013년까지 40세 이상의 남성 4,283명을 대상으로 질병군 및 정상군으로 나누어 총 테스토스테론을 포함한 혈액검사 및 임상자료를 두군간에 비교하였다.
3) 결과: 금번 연구에서 2,041명이 질병군(47.6%), 2,243명이 정상군(52.4%)이며 총 테스토스테론과 나이(r=0.032, P=0.034), HDL(r=0.133, P<0.001) 은 각각 양의 상관관계를 보이며, BMI(r=-0.198, P<0.001), 복부둘레(r=-0.184, P<0.001), 혈압, ALT(r=-0.132, P<0.001), 공복혈당(r=-0.105, P<0.001), TG(r=-0.119, P<0.001) 및 알부민(r=-0.108, P<0.001)은 각각 총 테스토스테론과 음의 상관관계를 보였다. 총 테스토스테론은 나이에 따라 증가하지 않았으며, 대사증후군, 고혈압, 및 당뇨병이 있는 사람들은 정상군에 비해 총 테스토스테론이 낮았다. 질병군이 남성갱년기에 이환될 확률이 정상군이 남성갱년기에 이환될 확률보다 1.595(95%CI, 1.355-1.876)배 높았다.
4) 결론: 정상군에서보다 질병군에서 총테스토스테론이 낮았다. 총테스토스테론은 나이가 아니라 질병에 의해 영향을 받는다.
ABSTRACT ⅰ
TABLE OF CONTENTS ⅱ
LIST OF FIGURES ⅲ
LIST OF TABLES ⅳ
Ⅰ. INTRODUCTION 1
Ⅱ. MATERIALS AND METHODS 3
Ⅲ. RESULTS 5
Ⅳ. DISCUSSION 11
Ⅴ. CONCLUSION 13
REFEENCES 14
국문요약 16
Master
Advisors/Committee Members: 대학원 의학과, 201224122, 최, 정우.
Subjects/Keywords: Testosterone; Chronic disease; Hypogonadism; Aging
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
최, . (2014). Testosterone might be influenced by co-morbidities, not by aging. (Thesis). Ajou University. Retrieved from http://repository.ajou.ac.kr/handle/201003/10905 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000016039
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
최, 정우. “Testosterone might be influenced by co-morbidities, not by aging.” 2014. Thesis, Ajou University. Accessed February 27, 2021.
http://repository.ajou.ac.kr/handle/201003/10905 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000016039.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
최, 정우. “Testosterone might be influenced by co-morbidities, not by aging.” 2014. Web. 27 Feb 2021.
Vancouver:
최 . Testosterone might be influenced by co-morbidities, not by aging. [Internet] [Thesis]. Ajou University; 2014. [cited 2021 Feb 27].
Available from: http://repository.ajou.ac.kr/handle/201003/10905 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000016039.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
최 . Testosterone might be influenced by co-morbidities, not by aging. [Thesis]. Ajou University; 2014. Available from: http://repository.ajou.ac.kr/handle/201003/10905 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000016039
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Houston
11.
-7536-267X.
The Effects of VO2max on Levels of Testosterone as Males Age.
Degree: MS, Kinesiology, University of Houston
URL: http://hdl.handle.net/10657/2761
► Purpose: The reduction of Testosterone secretion by the gonads is “hypogonadism” and development of age-related hypogonadism is known as “late-onset hypogonadism”. Late-onset hypogonadism is characterized…
(more)
▼ Purpose: The reduction of
Testosterone secretion by the gonads is “hypogonadism” and development of age-related hypogonadism is known as “late-onset hypogonadism”. Late-onset hypogonadism is characterized by issues such as osteoporosis, Alzheimer’s disease, frailty, obesity, cardiac failure and ischemic heart disease. The purpose of this investigation was to determine the impact of ⩒O2max on age-related declines in free and bound plasma
testosterone levels in healthy men. Methods: A total of 45 male subjects of various ethnicities aged 20-62 years participated in this study. Resting blood samples were collected, after which subjects were on cycle ergometer. Subjects started the trail and complete four three-minute heart rate adjusted incremental stages. The ⩒O2max of each
subject was estimated using a sub-maximal cycling exercise protocol. Free and Bound
testosterone was then removed from blood serum samples and measured. Results: High levels of aerobic fitness did not offset age-related declines in circulating levels of free
testosterone. While significant differences were found amongst the Young population (Low aerobic fitness versus High aerobic fitness) (p=0.045, F=2.912), this was not relevant to the investigation. Conclusion: After controlling for age, aerobic fitness did not prevent the age-associated decline in
Testosterone. Taking the results of this study into consideration when creating countermeasures for older adult males with symptoms of hypogonadism, it is suggested that an exercise countermeasure have a combination of endurance and strength training to help mediate levels of
testosterone with age.
Advisors/Committee Members: Simpson, Richard J. (advisor), Markofski, Melissa M. (advisor), Park, Yoonjung (committee member), Jennings, Kristofer (committee member).
Subjects/Keywords: Testosterone; Vo2max
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
-7536-267X. (n.d.). The Effects of VO2max on Levels of Testosterone as Males Age. (Masters Thesis). University of Houston. Retrieved from http://hdl.handle.net/10657/2761
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
No year of publication.
Chicago Manual of Style (16th Edition):
-7536-267X. “The Effects of VO2max on Levels of Testosterone as Males Age.” Masters Thesis, University of Houston. Accessed February 27, 2021.
http://hdl.handle.net/10657/2761.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
No year of publication.
MLA Handbook (7th Edition):
-7536-267X. “The Effects of VO2max on Levels of Testosterone as Males Age.” Web. 27 Feb 2021.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
No year of publication.
Vancouver:
-7536-267X. The Effects of VO2max on Levels of Testosterone as Males Age. [Internet] [Masters thesis]. University of Houston; [cited 2021 Feb 27].
Available from: http://hdl.handle.net/10657/2761.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
No year of publication.
Council of Science Editors:
-7536-267X. The Effects of VO2max on Levels of Testosterone as Males Age. [Masters Thesis]. University of Houston; Available from: http://hdl.handle.net/10657/2761
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
No year of publication.

University of Adelaide
12.
Haren, Matthew Timothy.
Endogenous serum testosterone in man: ageing, the metabolic syndrome, functional decline and the role of supplementation.
Degree: 2005, University of Adelaide
URL: http://hdl.handle.net/2440/37754
► This thesis investigates the age - related decline in the various available measures and estimates of serum testosterone levels in men. Testosterone circulates predominantly bound…
(more)
▼ This thesis investigates the age - related decline in the various available measures and estimates of serum
testosterone levels in men.
Testosterone circulates predominantly bound with high affinity to sex - hormone binging globulin ( SHBG ) in plasma ( ~ 60 % ) and with lower affinity to albumin ( < 40 % ) ; approximately 1 - 2 % circulates unbound in plasma. It is the albumin - bound and free fractions ( termed " bioavailable
testosterone " ) that are most likely to have biological effects on target tissues. This thesis reports the establishment,
validation and derivation of normal ranges for an ammonium sulphate precipitation method for the
measurement of bioavailable
testosterone in serum. This method is in use by a number of laboratories at present including the laboratory of Professor John Morley at St Louis University with whom we collaborated.
Testosterone has been shown, both cross - sectionally and longitudinally, to decline progressively beginning around the age of thirty. Total
testosterone declines at approximately 0.4 % per year while bioavailable and free
testosterone decline at approximately 1.2 % per year. The mechanisms that may be responsible for this include age - related changes to the hypothalamic - pituitary - testicular axis, increased SHBG levels, environmental factors, medication and chronic illness. This decline may contribute to a multitude of physiological, psychosexual and cognitive changes associated with ageing in men. This thesis crosssectionally
examines the possible determinants of the various fractions of serum
testosterone and the associations with various physical, psychosexual and lifestyle variables and with chronic disease and medication use. These cross - sectional data were generated from the Florey Adelaide Male Ageing study, which randomly recruited 568 men from the north and west suburbs of Adelaide, between August 2001 and August 2002.
Moreover, this thesis includes a randomised controlled trial of
testosterone replacement therapy in men aged 60 years and over with low - normal
testosterone levels at baseline, recruited by newspaper advertisement. The goals of
testosterone replacement therapy might be to prevent osteoporosis, age related frailty and falls, and to maintain optimal physical, sexual, emotional and cognitive health during the
ageing process. This intervention study focused on the effect of treatment on body composition and muscle strength, symptoms of
testosterone deficiency, visuospatial cognition, mood, wellbeing and quality of life.
Finally, preliminary work was initiated to develop an in vitro bioassay for the measurement of serum
testosterone bio - action. This was done using a transient transfection protocol in cultured cells, where androgen receptor and androgen response elements were introduced into the cells, subsequently treated with
testosterone containing media and the amplitude of response quantified using a dual - luciferasereporter
assay.
In summary, this thesis discusses the issues with the measurement of
testosterone in plasma and…
Advisors/Committee Members: Wittert, Gary Allen (advisor), Medical School (school).
Subjects/Keywords: hormones; testosterone
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Haren, M. T. (2005). Endogenous serum testosterone in man: ageing, the metabolic syndrome, functional decline and the role of supplementation. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/37754
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Haren, Matthew Timothy. “Endogenous serum testosterone in man: ageing, the metabolic syndrome, functional decline and the role of supplementation.” 2005. Thesis, University of Adelaide. Accessed February 27, 2021.
http://hdl.handle.net/2440/37754.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Haren, Matthew Timothy. “Endogenous serum testosterone in man: ageing, the metabolic syndrome, functional decline and the role of supplementation.” 2005. Web. 27 Feb 2021.
Vancouver:
Haren MT. Endogenous serum testosterone in man: ageing, the metabolic syndrome, functional decline and the role of supplementation. [Internet] [Thesis]. University of Adelaide; 2005. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/2440/37754.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Haren MT. Endogenous serum testosterone in man: ageing, the metabolic syndrome, functional decline and the role of supplementation. [Thesis]. University of Adelaide; 2005. Available from: http://hdl.handle.net/2440/37754
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Edinburgh
13.
Gibb, Fraser Wilson.
Metabolic effects of aromatase inhibition.
Degree: PhD, 2015, University of Edinburgh
URL: http://hdl.handle.net/1842/15838
► Aromatase, a member of the cytochrome P450 superfamily, catalyses the conversion of androgens to estrogens; specifically, testosterone to estradiol and androstenedione to estrone. Aromatase is…
(more)
▼ Aromatase, a member of the cytochrome P450 superfamily, catalyses the conversion of androgens to estrogens; specifically, testosterone to estradiol and androstenedione to estrone. Aromatase is widely expressed across a range of tissues and deleterious metabolic effects are observed in both murine aromatase knock-out models and in rare human cases of aromatase deficiency. The effects of pharmacological inhibition of aromatase, as employed in the treatment of breast cancer, are not well characterised. This thesis addresses the hypothesis that aromatase inhibition, and consequent changes in sex steroid hormone action (higher androgen:estrogen ratio), results in disadvantageous changes in body composition and reduced insulin sensitivity. In a cohort study of 197 community-dwelling men, lower testosterone and SHBG concentrations were observed in those fulfilling criteria for metabolic syndrome, although no relationship with estrogens was observed. The strongest determinant of circulating estrogens was substrate androgen concentration. A case-control study of aromatase inhibitor treated breast cancer patients and age-matched controls (n=40) demonstrated decreased insulin sensitivity and increased body fat in those treated with aromatase inhibitors; serum leptin concentration and leptin mRNA transcript levels (in subcutaneous adipose tissue) were elevated in this group. In healthy male volunteers (n=17), 6 weeks of aromatase inhibition (1 mg anastrozole daily) resulted in reduced glucose disposal during a hyperinsulinaemic euglycaemic clamp study, with d2-glucose and d5-glycerol tracers. No effects upon hepatic insulin sensitivity, lipolysis or body composition were noted, although serum leptin concentration was reduced following aromatase inhibitor administration. In conclusion, aromatase inhibition is associated with increased insulin resistance and, in women, increased body fat. This may be relevant for patients receiving aromatase inhibitor therapy, where more careful monitoring of glucose tolerance may be warranted.
Subjects/Keywords: 616.99; aromatase; testosterone; estradiol
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Gibb, F. W. (2015). Metabolic effects of aromatase inhibition. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/15838
Chicago Manual of Style (16th Edition):
Gibb, Fraser Wilson. “Metabolic effects of aromatase inhibition.” 2015. Doctoral Dissertation, University of Edinburgh. Accessed February 27, 2021.
http://hdl.handle.net/1842/15838.
MLA Handbook (7th Edition):
Gibb, Fraser Wilson. “Metabolic effects of aromatase inhibition.” 2015. Web. 27 Feb 2021.
Vancouver:
Gibb FW. Metabolic effects of aromatase inhibition. [Internet] [Doctoral dissertation]. University of Edinburgh; 2015. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/1842/15838.
Council of Science Editors:
Gibb FW. Metabolic effects of aromatase inhibition. [Doctoral Dissertation]. University of Edinburgh; 2015. Available from: http://hdl.handle.net/1842/15838

Grand Valley State University
14.
Madanu, Sampath.
The Acute Responses of Different-sized Coronary Arteries to Testosterone.
Degree: 2012, Grand Valley State University
URL: https://scholarworks.gvsu.edu/theses/30
► Coronary arteries supply blood to the myocardium. The blood flow within the coronary arteries is altered by various compounds produced within the body. Sex hormones…
(more)
▼ Coronary arteries supply blood to the myocardium. The blood flow within the coronary arteries is altered by various compounds produced within the body. Sex hormones such as testosterone are known to cause the relaxation of large coronary arteries. But the response to testosterone is greater in in vivo conditions compared to in vitro conditions. We hypothesize that the responses of LADs (left anterior descending arteries) and its side branches to testosterone are heterogeneous and testosterone-induced vasodilation is greater in its side branches. Therefore, our study was designed to determine the effect of testosterone in different-sized coronary arteries. LADs and one of its side branches were isolated from porcine hearts and mounted in organ baths to mimic in vivo conditions. The coronary arteries were then preconstricted with potassium chloride (KCl) and administered increasing concentrations of testosterone to determine if the responses to testosterone vary within different regions of the coronary circulation. The testosterone caused significant relaxation in both LADs and its side branches. However the side branches showed similar responses to testosterone as compared to the larger, upstream LADs. Further studies on androgen receptor expression using real time PCR indicated that androgen receptor expression was higher in LADs than its side branches. A third group of small coronary arteries exhibited greater androgen receptor expression than the LADs and its side branches. The enhanced testosterone-induced vascular reactivity exhibited in vivo may be at the level of the small coronary arteries, not the LAD and its side branches.
Subjects/Keywords: response; coronary arteries; testosterone
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Madanu, S. (2012). The Acute Responses of Different-sized Coronary Arteries to Testosterone. (Thesis). Grand Valley State University. Retrieved from https://scholarworks.gvsu.edu/theses/30
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Madanu, Sampath. “The Acute Responses of Different-sized Coronary Arteries to Testosterone.” 2012. Thesis, Grand Valley State University. Accessed February 27, 2021.
https://scholarworks.gvsu.edu/theses/30.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Madanu, Sampath. “The Acute Responses of Different-sized Coronary Arteries to Testosterone.” 2012. Web. 27 Feb 2021.
Vancouver:
Madanu S. The Acute Responses of Different-sized Coronary Arteries to Testosterone. [Internet] [Thesis]. Grand Valley State University; 2012. [cited 2021 Feb 27].
Available from: https://scholarworks.gvsu.edu/theses/30.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Madanu S. The Acute Responses of Different-sized Coronary Arteries to Testosterone. [Thesis]. Grand Valley State University; 2012. Available from: https://scholarworks.gvsu.edu/theses/30
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Windsor
15.
Vandenborn, Elizabeth Theresa.
What makes girls participate in sport? An analysis of biological correlates of sport participation.
Degree: M.H.K., Kinesiology, 2017, University of Windsor
URL: https://scholar.uwindsor.ca/etd/6021
► Introduction: Females are currently participating in sport at a lower rate than males. It has been determined that girls who participate in sport gain many…
(more)
▼ Introduction: Females are currently participating in sport at a lower rate than males. It has been determined that girls who participate in sport gain many advantages (i.e. better bone health, greater cardio-respiratory fitness, a better quality of life). Therefore, it’s important to determine why some females choose to continue sport participation, while others do not. Objective: To determine if 2DR and salivary
testosterone (sT) are correlates of sport participation. Methods: A cross-sectional analysis of resting and indirect prenatal androgen concentrations (i.e. second to fourth digit ratios) were obtained from a sample of 18-30y females. Participant demographic (via questionnaire), anthropometric, behavioural (via questionnaire), and retrospective sport participation (via questionnaire) information were collected on one occasion and saliva was collected on two occasions. Results: 2DR ratio (r = -0.650, p = 0.538) was not significantly correlated with total sport participation, nor was sT (r = 0.094, p = 0.387). Secondary analysis revealed significant correlations between sport participation and max hand grip (r=.406, p = 0.000), sport competitiveness (Sport Orientation Questionnaire) (r = 0.475, p = 0.000) and Sport Aggression (Scale of Children’s Action Tendencies in Sport) (r = 0.240, p = 0.021). Conclusion: It does not appear that androgens (whether prenatally or current) have an impact on female sport participation. Given that females participate in sport at lower rates than males, and that sport provides multiple social and health advantages, continuing to determine what factors influence sport participation is necessary.
Advisors/Committee Members: Milne, Kevin.
Subjects/Keywords: females; participation; sport; testosterone
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Chicago ·
MLA ·
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CSE |
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to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Vandenborn, E. T. (2017). What makes girls participate in sport? An analysis of biological correlates of sport participation. (Masters Thesis). University of Windsor. Retrieved from https://scholar.uwindsor.ca/etd/6021
Chicago Manual of Style (16th Edition):
Vandenborn, Elizabeth Theresa. “What makes girls participate in sport? An analysis of biological correlates of sport participation.” 2017. Masters Thesis, University of Windsor. Accessed February 27, 2021.
https://scholar.uwindsor.ca/etd/6021.
MLA Handbook (7th Edition):
Vandenborn, Elizabeth Theresa. “What makes girls participate in sport? An analysis of biological correlates of sport participation.” 2017. Web. 27 Feb 2021.
Vancouver:
Vandenborn ET. What makes girls participate in sport? An analysis of biological correlates of sport participation. [Internet] [Masters thesis]. University of Windsor; 2017. [cited 2021 Feb 27].
Available from: https://scholar.uwindsor.ca/etd/6021.
Council of Science Editors:
Vandenborn ET. What makes girls participate in sport? An analysis of biological correlates of sport participation. [Masters Thesis]. University of Windsor; 2017. Available from: https://scholar.uwindsor.ca/etd/6021

University of Southern California
16.
Wang, Chien-Hua.
Wired on hormones: sexual dimorphism of leptin-sensitive
projections.
Degree: PhD, Neuroscience, 2013, University of Southern California
URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/292699/rec/7953
► The adipocyte-derived hormone leptin plays a key role in regulating energy homeostasis and reproduction in adults. A compelling body of evidence indicates that the efficacy…
(more)
▼ The adipocyte-derived hormone leptin plays a key role
in regulating energy homeostasis and reproduction in adults. A
compelling body of evidence indicates that the efficacy of leptin
to suppress food intake and increase energy expenditure is
dependent on the neuroarchitecture of the feeding circuitry
programmed by leptin during development. This neurotrophic action
of leptin shares many aspects of developmental functions of sex
steroid hormones. Moreover, overlapping central targets of these
two hormones raises the possibility that leptin and sex steroids
may interact to direct key neurodevelopmental events. The ventral
premammillary nucleus (PMv) contains a high density of neurons
expressing leptin receptors (LRb) and androgen receptors (AR),
making the PMv an excellent model system to study the developmental
effect of the interactions between these two hormones. To this end,
this thesis focuses on examining how developmental interactions
between leptin and
testosterone specify the development of PMv
connectivity and the mechanisms underlying this interaction. ❧ In
the first half of this thesis we characterize the ontogeny of PMv
projections and determine how leptin or
testosterone specifies PMv
connectivity in male and female mice. Using both in vivo
loss-of-function and in vitro gain-of-function assays, in
conjunction with immunohistological staining, in a leptin deficient
mouse model, we show that the PMv connectivity is sexually
dimorphic due to a
testosterone-dependent trophic action of leptin.
❧ In the second half of the thesis we investigate the cellular
mechanisms that underlie the neurodevelopmental effects of leptin
and
testosterone. Taking advantage of transgenic mouse models
lacking AR or impaired in specific LRb signaling, we show that the
testosterone-dependent trophic action of leptin is mediated through
AR. In addition, our data demonstrate that during development LRb
and AR signaling converges on the ERK pathway and to a lesser
extent, on the STAT3 pathway, to synergistically promote neurite
outgrowth from PMv neurons. In adults, AR signaling potentiates
STAT3 activation in PMv neurons in response to leptin injection,
which corresponds to a greater sensitivity to leptin-induced
bodyweight loss in adult male mice. ❧ In summary, we demonstrate
that metabolic hormone leptin can affect the wiring of reproductive
circuitry in a sexually dimorphic manner. This dissertation
highlights the biological importance of hormonal interactions
during brain development and provides insight into the mechanisms
responsible for sex linked aberrations in neural connectivity that
contributes a variety of hormone-sensitive neurological
disorders.
Advisors/Committee Members: Watts, Alan G. (Committee Chair), Simerly, Richard B. (Committee Member), Swanson, Larry W. (Committee Member), Peti-Peterdi, Janos (Committee Member).
Subjects/Keywords: ventral premammillary nucleus; testosterone; development
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Wang, C. (2013). Wired on hormones: sexual dimorphism of leptin-sensitive
projections. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/292699/rec/7953
Chicago Manual of Style (16th Edition):
Wang, Chien-Hua. “Wired on hormones: sexual dimorphism of leptin-sensitive
projections.” 2013. Doctoral Dissertation, University of Southern California. Accessed February 27, 2021.
http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/292699/rec/7953.
MLA Handbook (7th Edition):
Wang, Chien-Hua. “Wired on hormones: sexual dimorphism of leptin-sensitive
projections.” 2013. Web. 27 Feb 2021.
Vancouver:
Wang C. Wired on hormones: sexual dimorphism of leptin-sensitive
projections. [Internet] [Doctoral dissertation]. University of Southern California; 2013. [cited 2021 Feb 27].
Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/292699/rec/7953.
Council of Science Editors:
Wang C. Wired on hormones: sexual dimorphism of leptin-sensitive
projections. [Doctoral Dissertation]. University of Southern California; 2013. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/292699/rec/7953

California State University – Chico
17.
Cook, Carolyn.
Getting the Word Out: Sharing the Benefits of Vaginally Applied Testosterone Cream in the Perimenopausal Years
.
Degree: 2010, California State University – Chico
URL: http://hdl.handle.net/10211.4/193
► ABSTRACT GETTING THE WORD OUT: SHARING THE BENEFITS OF VAGINALLY APPLIED TESTOSTERONE CREAM IN THE PERIMENOPAUSAL YEARS by Carolyn Cook Master of Science in Nursing…
(more)
▼ ABSTRACT
GETTING THE WORD OUT: SHARING THE BENEFITS OF
VAGINALLY APPLIED
TESTOSTERONE CREAM IN
THE PERIMENOPAUSAL YEARS
by
Carolyn Cook
Master of Science in Nursing
California State University, Chico
Spring 2010
Testosterone has been used for over 40 years to treat symptoms of decreased
libido in menopausal women. This thesis describes a qualitative study in which six
women of perimenopausal age were interviewed about their experiences with
testosterone
replacement therapy using a vaginally applied
testosterone cream. In-depth interviews
were conducted and four themes emerged: seeking to combat the consequences of
aging, gaining benefits of
testosterone, balancing the side effects, and appreciating the
male perspective. While the benefits and side effects of
testosterone use in women are
well-documented in the literature, little has been written about women???s overall perceptions
of their experiences with
testosterone. This information may be useful to nursing
educators, students, and nurses practicing in the field of Women???s Health, all of whom
vii
should be aware of the potential benefits of
testosterone therapy in women, as hormone
replacement therapy becomes more widespread.
Advisors/Committee Members: Gardner, Janelle D (advisor).
Subjects/Keywords: Testosterone Cream
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Cook, C. (2010). Getting the Word Out: Sharing the Benefits of Vaginally Applied Testosterone Cream in the Perimenopausal Years
. (Thesis). California State University – Chico. Retrieved from http://hdl.handle.net/10211.4/193
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Cook, Carolyn. “Getting the Word Out: Sharing the Benefits of Vaginally Applied Testosterone Cream in the Perimenopausal Years
.” 2010. Thesis, California State University – Chico. Accessed February 27, 2021.
http://hdl.handle.net/10211.4/193.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Cook, Carolyn. “Getting the Word Out: Sharing the Benefits of Vaginally Applied Testosterone Cream in the Perimenopausal Years
.” 2010. Web. 27 Feb 2021.
Vancouver:
Cook C. Getting the Word Out: Sharing the Benefits of Vaginally Applied Testosterone Cream in the Perimenopausal Years
. [Internet] [Thesis]. California State University – Chico; 2010. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/10211.4/193.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Cook C. Getting the Word Out: Sharing the Benefits of Vaginally Applied Testosterone Cream in the Perimenopausal Years
. [Thesis]. California State University – Chico; 2010. Available from: http://hdl.handle.net/10211.4/193
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universiteit Utrecht
18.
Montoya, E.R.
Shaped and Balanced by Hormones : cortisol, testosterone and the psychoneuroendocrinology of human socio-emotional behavior.
Degree: 2015, Universiteit Utrecht
URL: http://dspace.library.uu.nl:8080/handle/1874/313285
► The steroid hormones testosterone and cortisol can be considered hormones for environmental challenges; they are involved in adaptive neural and behavioral responses towards emotional stimuli.…
(more)
▼ The steroid hormones
testosterone and cortisol can be considered hormones for environmental challenges; they are involved in adaptive neural and behavioral responses towards emotional stimuli. A key challenge of human psychoneuroendocrinology is to unravel the neural mechanisms by which
testosterone and cortisol act on the brain to give rise to their effects on socio-emotional behaviors. Therefore, one of the main goals of the research reported in this thesis is to investigate neural mechanisms underlying the effects of cortisol on fear, reward and parenting behaviors. Another important challenge for human psychoneuroendocrinology is to investigate if the effects of hormones extend to behaviors that can be considered uniquely human. Hence, a second main goal is to investigate if
testosterone influences higher order social functions, such as social cooperation and morality. Finally, hormones do not work in isolation: they interact with early life factors such as the prenatal hormonal milieu and early life stress such as childhood trauma. Another goal of this thesis is therefore to gather more insights in how theses early life factors interact with the effects of steroid hormones.
To these ends, this thesis includes a literature review and empirical studies employing single administration of cortisol and
testosterone together with neuroimaging and behavioral paradigms. A marker of prenatal
testosterone is used in the
testosterone studies, based on animal studies showing that prenatal
testosterone programs the effects of the hormone in adult life. Childhood trauma is taken into account in the cortisol studies, as previous animal and human studies have demonstrated that this is an important factor in shaping the cortisol system.
This thesis starts with a literature review that discusses evidence for the notion that
testosterone and cortisol, together with serotonin, regulates reactive aggression. The evidence suggests that high
testosterone and low cortisol levels together increases the occurrence of social aggression, and that low serotonin on top of this imbalance might specifically predispose towards impulsive aggression instead of instrumental aggression. This literature overview proposes this hypothesis as a guide for future research and provided the theoretical framework for the following studies.
The findings of the first empirical part of this thesis show that cortisol modulates the brain systems important for reward, fear and parenting. It is also observed that early life factors such as childhood trauma shape the effects of cortisol on neural processing of stimuli important for parenting.
The findings of the second empirical part of this thesis show that
testosterone, in addition to affecting basal emotional processes such as fear and reward processing, also affects higher order social functions such as social cooperation and moral judgement. By using a proxy for prenatal
testosterone exposure, it is shown that the effects of…
Advisors/Committee Members: Honk, E.J. van, Terburg, D., Bos, P.A..
Subjects/Keywords: testosterone; cortisol; social behavior; emotion; prenatal testosterone; childhood trauma; neuroimaging
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Montoya, E. R. (2015). Shaped and Balanced by Hormones : cortisol, testosterone and the psychoneuroendocrinology of human socio-emotional behavior. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/313285
Chicago Manual of Style (16th Edition):
Montoya, E R. “Shaped and Balanced by Hormones : cortisol, testosterone and the psychoneuroendocrinology of human socio-emotional behavior.” 2015. Doctoral Dissertation, Universiteit Utrecht. Accessed February 27, 2021.
http://dspace.library.uu.nl:8080/handle/1874/313285.
MLA Handbook (7th Edition):
Montoya, E R. “Shaped and Balanced by Hormones : cortisol, testosterone and the psychoneuroendocrinology of human socio-emotional behavior.” 2015. Web. 27 Feb 2021.
Vancouver:
Montoya ER. Shaped and Balanced by Hormones : cortisol, testosterone and the psychoneuroendocrinology of human socio-emotional behavior. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2015. [cited 2021 Feb 27].
Available from: http://dspace.library.uu.nl:8080/handle/1874/313285.
Council of Science Editors:
Montoya ER. Shaped and Balanced by Hormones : cortisol, testosterone and the psychoneuroendocrinology of human socio-emotional behavior. [Doctoral Dissertation]. Universiteit Utrecht; 2015. Available from: http://dspace.library.uu.nl:8080/handle/1874/313285

Boston University
19.
Clausen, Jonathan.
The long-term effects of testosterone replacement therapy in aging males with late-onset hypogonadism.
Degree: MS, Medical Sciences, 2020, Boston University
URL: http://hdl.handle.net/2144/41193
► Late-onset hypogonadism (LOH) is a pathological disorder that develops in males over the age of 40 and is diagnosed upon strict criteria that requires that…
(more)
▼ Late-onset hypogonadism (LOH) is a pathological disorder that develops in males over the age of 40 and is diagnosed upon strict criteria that requires that the individual have total serum
testosterone (T) below the normal limits as well as three symptoms of sexual dysfunction. Recommended therapy for young males with hypogonadism is
testosterone replacement therapy (TRT). Treatment of LOH with TRT has increased significantly in the past several years, but studies showing adverse risks associated with TRT have led to a growing concern about the safety of such a treatment. This systematic review will give an overview of the pathology of LOH, clinical diagnosis of LOH, and comorbidities associated with this dysfunction. Benefits of TRT in elderly hypogonadal men have included improvement in cardiovascular function, reduced all-cause mortality, increased sexual function, increased bone mineral density, improved body composition, increased muscle strength, improved quality of life, and improvement in metabolic parameters. However, risks associated with TRT have included infertility, worsening lipid panel parameters, polycythemia, increased risk of prostate cancer, and in some cases, increased risk of adverse cardiovascular events.
Advisors/Committee Members: Moussavi, Mina (advisor), Stearns-Kurosawa, Deborah J. (advisor).
Subjects/Keywords: Medicine; Aging; Hypogonadism; Late-onset hypogonadism; Male; Testosterone; Testosterone replacement therapy
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Clausen, J. (2020). The long-term effects of testosterone replacement therapy in aging males with late-onset hypogonadism. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/41193
Chicago Manual of Style (16th Edition):
Clausen, Jonathan. “The long-term effects of testosterone replacement therapy in aging males with late-onset hypogonadism.” 2020. Masters Thesis, Boston University. Accessed February 27, 2021.
http://hdl.handle.net/2144/41193.
MLA Handbook (7th Edition):
Clausen, Jonathan. “The long-term effects of testosterone replacement therapy in aging males with late-onset hypogonadism.” 2020. Web. 27 Feb 2021.
Vancouver:
Clausen J. The long-term effects of testosterone replacement therapy in aging males with late-onset hypogonadism. [Internet] [Masters thesis]. Boston University; 2020. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/2144/41193.
Council of Science Editors:
Clausen J. The long-term effects of testosterone replacement therapy in aging males with late-onset hypogonadism. [Masters Thesis]. Boston University; 2020. Available from: http://hdl.handle.net/2144/41193

University of KwaZulu-Natal
20.
Paruk, Imran Mahomed.
Prevalence of low serum testosterone levels among men with type 2 diabetes mellitus attending two outpatient diabetes clinics in Durban, South Africa.
Degree: 2017, University of KwaZulu-Natal
URL: https://researchspace.ukzn.ac.za/handle/10413/17479
► Background: Studies showing a high prevalence of low serum testosterone in men with type 2 diabetes mellitus (T2DM) are well documented but evidence from sub-Saharan…
(more)
▼ Background: Studies showing a high prevalence of low serum
testosterone in men with type 2 diabetes mellitus (T2DM) are well documented but evidence from sub-Saharan Africa is scanty.
Aim: To determine the prevalence and associated risk factors of low serum
testosterone and the prevalence of androgen deficiency symptoms in South African men with T2DM.
Methods: A cross-sectional observational study was performed among men with T2DM attending two outpatient adult diabetes clinics in KwaZulu-Natal. Androgen deficiency symptoms were assessed using the Ageing Male’s Symptom Scale (AMS) questionnaire and direct enquiry. Serum total
testosterone (TT), sex-hormone binding globulin (SHBG), luteinising hormone (LH), HbA1c, fructosamine, serum lipids were measured and free-
testosterone (FT) was calculated. TT, SHBG and FT levels were measured in control subjects with no history of diabetes.
Results: The study included 148 men with T2DM (Study Group) and 50 control subjects (Control Group). The mean age of the control group was 43.9 ± 10.7 years and the mean BMI was 27.11 ± 4.2 kg/m2. In the study group, the majority were African (Black) (58.7%); Indians (39.2%) and Whites (2.1%) constituted the remainder. Mean age was 57.5 ± 11.2 years; mean duration of diabetes 11.4 ± 8.9 years; mean HbA1c was 8.6 ± 1.9%. Metabolic syndrome was found in 86.4% (n:127) of the Study group. Mean TT, SHBG, FT and median LH (IQR) in the Study group were within normal range (14.5 ± 5.8 nmol/l, 40.7 ± 20.3 nmol/l, 265.9 ± 90.4 pmol/l and 5.3 [3.8-7.3] IU/l, respectively). However, mean serum TT and FT was lower in the Study group than Control subjects (14.5 ± 5.8 vs. 18.8 ± 7.2 nmol/l, p <0.001 and 265.9 ± 90.4 vs. 351.7 ± 127.3 pmol/l, p<0.001).
The prevalence of LSTT and LSFT was 35.8% and 16.2%, respectively. Prevalence of LSFT increased with age and higher body mass index (BMI) categories with the highest rate noted in >40 kg/m2 BMI category (50%).
In multivariate analysis, LSFT was significantly associated with age [OR 1.05 (95% CI 1.02-1.218), p=0.043] and waist circumference (WC) [OR 1.033 (95% CI 0.999- 1.068), p=0.059]. LSTT was associated with BMI only [OR 1.138 (95%CI 1.063- 1.218), p<0.0001]. TT correlated inversely with BMI, WC and the number of metabolic syndrome criteria. FT correlated inversely with BMI, WC and WHR. For both FT and TT, no significant correlation was observed with HbA1c.
The prevalence of androgen deficiency symptoms using AMS score was 74.5%. The prevalence of any androgen deficiency symptom on direct enquiry was 68.9%. The AMS score correlated poorly with LSTT or LSFT and was not superior to direct enquiry.
Conclusion: In this group of predominantly African and Indian men with T2DM from KwaZulu-Natal, there was a high prevalence of LSTT and LSFT. Serum TT and FT was lower in men with T2DM compared to control subjects. Waist circumference was a significant risk factor associated with LSFT while LSTT was associated with higher BMI and older age. There was a high prevalence of androgen deficiency symptoms using…
Advisors/Committee Members: Motala, Ayesha Ahmed. (advisor), Pirie, Fraser James. (advisor).
Subjects/Keywords: Testosterone.; Type 2 diabetes.; Androgen deficiency symptoms.; Low serum testosterone.; Men.
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Paruk, I. M. (2017). Prevalence of low serum testosterone levels among men with type 2 diabetes mellitus attending two outpatient diabetes clinics in Durban, South Africa. (Thesis). University of KwaZulu-Natal. Retrieved from https://researchspace.ukzn.ac.za/handle/10413/17479
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Paruk, Imran Mahomed. “Prevalence of low serum testosterone levels among men with type 2 diabetes mellitus attending two outpatient diabetes clinics in Durban, South Africa.” 2017. Thesis, University of KwaZulu-Natal. Accessed February 27, 2021.
https://researchspace.ukzn.ac.za/handle/10413/17479.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Paruk, Imran Mahomed. “Prevalence of low serum testosterone levels among men with type 2 diabetes mellitus attending two outpatient diabetes clinics in Durban, South Africa.” 2017. Web. 27 Feb 2021.
Vancouver:
Paruk IM. Prevalence of low serum testosterone levels among men with type 2 diabetes mellitus attending two outpatient diabetes clinics in Durban, South Africa. [Internet] [Thesis]. University of KwaZulu-Natal; 2017. [cited 2021 Feb 27].
Available from: https://researchspace.ukzn.ac.za/handle/10413/17479.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Paruk IM. Prevalence of low serum testosterone levels among men with type 2 diabetes mellitus attending two outpatient diabetes clinics in Durban, South Africa. [Thesis]. University of KwaZulu-Natal; 2017. Available from: https://researchspace.ukzn.ac.za/handle/10413/17479
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University
21.
De Lorme, Kayla.
The organizational effects of pubertal testosterone on the maturation of adult social cognition and social proficiency.
Degree: 2013, Michigan State University
URL: http://etd.lib.msu.edu/islandora/object/etd:2076
► Thesis Ph. D. Michigan State University. Psychology 2013.
Maturation of social cognition and a gain in social proficiency are universal aspects of adolescent development that…
(more)
▼ Thesis Ph. D. Michigan State University. Psychology 2013.
Maturation of social cognition and a gain in social proficiency are universal aspects of adolescent development that prepare an individual for adulthood. Social cognition involves the perception and interpretation of social cues, followed by the generation of a behavioral response. Social proficiency is acquired through the ability to make behavioral adaptations as one learns from social experience. The pubertal rise in testosterone secretion results in both activation and organization of the neural circuits underlying adult male social behaviors, including sexual behavior, which may contribute to the developmental changes in social cognition and gain in sexual proficiency. To assess the contribution of pubertal testosterone to the maturation of adult social behavior, we utilize the [email protected]/[email protected] experimental animal model. In this model, male Syrian hamsters are deprived of testosterone during puberty (defined as [email protected]) or for an equivalent amount of time during adulthood (defined as [email protected]) and then given testosterone replacement in adulthood for two weeks before behavior testing. If [email protected] and [email protected] males differ in behavior, we infer that the difference is due to organizational effects of pubertal testosterone. If [email protected] and [email protected] males show similar behavior, then we infer that the adolescent maturation of that behavior is due to hormone-independent or activational actions. We first tested the hypothesis that the adolescent acquisition of social reward does not depend on organizational effects of pubertal testosterone. We found that both [email protected] and [email protected] males show a CPP for vaginal secretions and a receptive female, indicating that the adolescent maturation of social reward is independent of pubertal testosterone. Second, we tested the hypothesis the adolescent gain in sexual proficiency does depend on organizational effects of testosterone. When sexual experience is equated for both [email protected] and [email protected] males, [email protected] males do not inhibit maladaptive behaviors with sexual experience, whereas [email protected] males do. These data suggest that testosterone during puberty programs the ability to adapt behaviors (via inhibition) in a social context-dependent manner. Third, we tested whether pubertal testosterone organizes the adolescent gain in sexual proficiency through the regulation of the transcription factor ΔFosB in the infralimbic medial prefrontal cortex (IL). We found that ∆FosB was induced in the IL after sexual experience in [email protected], but not [email protected], males. Furthermore, over-expression of ∆FosB in the IL of [email protected] males prior to sexual behavior testing was sufficient to reverse the deficits in behavioral inhibition found in [email protected] males. Taken together, these data provide evidence that social reward develops independently of pubertal testosterone, whereas the ability to inhibit inappropriate behavior is organized by pubertal testosterone through the regulation of ∆FosB in the IL.
Description based on online resource; title from PDF t.p. (ProQuest, viewed on…
Advisors/Committee Members: Sisk, Cheryl L., Burt, S. Alexandra, Conrad, Susan E., Lonstein, Joseph S., Robison, Alfred J..
Subjects/Keywords: Adolescence; Social perception; Testosterone; Sex; Psychology; Neurosciences; Pubertal testosterone
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
De Lorme, K. (2013). The organizational effects of pubertal testosterone on the maturation of adult social cognition and social proficiency. (Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:2076
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
De Lorme, Kayla. “The organizational effects of pubertal testosterone on the maturation of adult social cognition and social proficiency.” 2013. Thesis, Michigan State University. Accessed February 27, 2021.
http://etd.lib.msu.edu/islandora/object/etd:2076.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
De Lorme, Kayla. “The organizational effects of pubertal testosterone on the maturation of adult social cognition and social proficiency.” 2013. Web. 27 Feb 2021.
Vancouver:
De Lorme K. The organizational effects of pubertal testosterone on the maturation of adult social cognition and social proficiency. [Internet] [Thesis]. Michigan State University; 2013. [cited 2021 Feb 27].
Available from: http://etd.lib.msu.edu/islandora/object/etd:2076.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
De Lorme K. The organizational effects of pubertal testosterone on the maturation of adult social cognition and social proficiency. [Thesis]. Michigan State University; 2013. Available from: http://etd.lib.msu.edu/islandora/object/etd:2076
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Youngstown State University
22.
Alcorn, John F., Jr.
The effects of castration on relaxation of Rat Corpus
Cavernosum Smooth Muscle in vitro.
Degree: MSin Biological Sciences, Department of Biological Sciences and
Chemistry, 1998, Youngstown State University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=ysu997194448
► Purpose: This study was conducted to investigate the role of testosterone in regulating the relaxation of isolated rat corpus cavernosum strips in vitro. Materials and…
(more)
▼ Purpose: This study was conducted to investigate the
role of
testosterone in regulating the relaxation of isolated rat
corpus cavernosum strips in vitro. Materials and Methods: Male rats
were divided into treatment groups of intact, castrate, and
castrate with
testosterone replacement. Norepinephrine was added to
contract each of the tissue strips. Next, sodium nitroprusside,
experiment I, or 8-bromo-cGMP, experiment II, was added to relax
the cavernosum tissue. Percent relaxations were recorded for each
treatment group at each dose level. Results: Sodium nitroprusside
was added to the norepinephrine contracted tissues in doses of 10
-4 and 10
-3 M. In
this experiment, castration significantly reduced tissue
responsiveness to sodium nitroprusside and
testosterone replacement
restored the response to intact levels. In the second experiment
8-bromo-cGMP was added to the norepinephrine contracted tissues in
doses of 10
-5 and 10
-4 M 8-bromo-cGMP 10
-4 M was significantly less effective in
relaxing tissue from castrate animals as compared to intact
controls. Again,
testosterone treatment restored the response to
intact levels. Conclusions: Our results show a clear role of
testosterone in regulating the ability of corpus cavernosum tissue
to relax when treated with sodium nitroprusside or 8-bromo-cGMP in
vitro. In addition, the data suggests that
testosterone regulates
sites distal to the formation of cGMP in this smooth muscle
relaxation pathway.
Advisors/Committee Members: Leipheimer, Robert (Advisor).
Subjects/Keywords: testosterone effects; testosterone replacement
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Alcorn, John F., J. (1998). The effects of castration on relaxation of Rat Corpus
Cavernosum Smooth Muscle in vitro. (Masters Thesis). Youngstown State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ysu997194448
Chicago Manual of Style (16th Edition):
Alcorn, John F., Jr. “The effects of castration on relaxation of Rat Corpus
Cavernosum Smooth Muscle in vitro.” 1998. Masters Thesis, Youngstown State University. Accessed February 27, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=ysu997194448.
MLA Handbook (7th Edition):
Alcorn, John F., Jr. “The effects of castration on relaxation of Rat Corpus
Cavernosum Smooth Muscle in vitro.” 1998. Web. 27 Feb 2021.
Vancouver:
Alcorn, John F. J. The effects of castration on relaxation of Rat Corpus
Cavernosum Smooth Muscle in vitro. [Internet] [Masters thesis]. Youngstown State University; 1998. [cited 2021 Feb 27].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ysu997194448.
Council of Science Editors:
Alcorn, John F. J. The effects of castration on relaxation of Rat Corpus
Cavernosum Smooth Muscle in vitro. [Masters Thesis]. Youngstown State University; 1998. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ysu997194448

Universiteit Utrecht
23.
Brand, J.S.M.
Testosterone, SHBG and cardiovascular health in postmenopausal women.
Degree: 2010, Universiteit Utrecht
URL: http://dspace.library.uu.nl:8080/handle/1874/39518
► Cardiovascular disease (CVD) affects men and women differently with women having a lower incidence and later onset of disease. Research has recently refocused interest into…
(more)
▼ Cardiovascular disease (CVD) affects men and women differently with women having a lower incidence and later onset of disease. Research has recently refocused interest into the cardiovascular role of androgens. The purpose of this review is to summarize the evidence available on the association between
testosterone and cardiovascular health in postmenopausal women. Published studies relating
testosterone and sex-hormone binding globulin (SHBG) levels to cardiovascular disease and its risk factors were reviewed. Studies included in this review suggest that increased androgenicity, characterized by high
testosterone and low SHBG levels, has a neutral to adverse effect on cardiovascular health in postmenopausal women. However, long-term data on cardiovascular effects of endogenous and exogenous
testosterone are scarce and many studies are limited by the use of insensitive and inaccurate
testosterone assays. Large-scale, longitudinal studies relating
testosterone and SHBG levels to cardiovascular risk factors and endpoints are needed to determine the temporal relationship between androgenicity and cardiovascular risk and to ascertain the efficacy and safety of
testosterone therapy in postmenopausal women.
Advisors/Committee Members: van der Schouw, Y.T..
Subjects/Keywords: Geneeskunde; testosterone, SHBG, cardiovascular disease, postmenopausal women
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Brand, J. S. M. (2010). Testosterone, SHBG and cardiovascular health in postmenopausal women. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/39518
Chicago Manual of Style (16th Edition):
Brand, J S M. “Testosterone, SHBG and cardiovascular health in postmenopausal women.” 2010. Masters Thesis, Universiteit Utrecht. Accessed February 27, 2021.
http://dspace.library.uu.nl:8080/handle/1874/39518.
MLA Handbook (7th Edition):
Brand, J S M. “Testosterone, SHBG and cardiovascular health in postmenopausal women.” 2010. Web. 27 Feb 2021.
Vancouver:
Brand JSM. Testosterone, SHBG and cardiovascular health in postmenopausal women. [Internet] [Masters thesis]. Universiteit Utrecht; 2010. [cited 2021 Feb 27].
Available from: http://dspace.library.uu.nl:8080/handle/1874/39518.
Council of Science Editors:
Brand JSM. Testosterone, SHBG and cardiovascular health in postmenopausal women. [Masters Thesis]. Universiteit Utrecht; 2010. Available from: http://dspace.library.uu.nl:8080/handle/1874/39518
24.
Cavalheiro, Ana Sofia Silva.
Efeito da violação de expectativas no comportamento e na resposta de testosterona à competição.
Degree: 2014, ISPA
URL: http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ispa.pt:10400.12/3601
► Dissertação de Mestrado apresentada ao ISPA - Instituto Universitário
Tem sido proposto na literatura que, em humanos, a resposta da testosterona à competição possa ser…
(more)
▼ Dissertação de Mestrado apresentada ao ISPA - Instituto Universitário
Tem sido proposto na literatura que, em humanos, a resposta da testosterona à competição possa ser modulada por variáveis cognitivas. Neste estudo, testamos a hipótese de que as variações dos níveis de testosterona, verificadas após uma competição, não estejam tão relacionadas com o resultado em si mas antes com a forma como o sujeito avalia o evento em questão, em particular com as suas expectativas acerca da competição. Para isso, foram manipuladas as expectativas que um grupo de participantes, do sexo feminino, criou acerca de uma competição e do seu resultado. Foi construída uma tarefa, em contexto laboratorial, que nos possibilitou a manipulação das suas expectativas. Assim, as participantes foram distribuídas por dois grupos artificiais e foi-lhes fornecido um falso feedback, que lhes direcionava as expectativas. Desta forma, os dados recolhidos apresentam informação acerca de participantes que perderam ou ganharam, em situações de confirmação de expectativas ou de violação de expectativas. Posto isto, colocou-se a hipótese de que se obteria maior resposta de testosterona nas participantes vencedoras, comparativamente com as derrotadas, de acordo com o modelo biossocial e avançou-se com a possibilidade de uma maior amplificação desta resposta de testosterona, quando as expectativas eram violadas. De facto, a última predição, confirmou-se, houve uma diferença significativa na variação de T, entre vencedoras e derrotadas, apenas nas sessões em que as expectativas das participantes foram violadas. Contudo, ao contrário do esperado, encontrou-se evidência de um resultado inverso ao modelo biossocial, as participantes que venceram a competição apresentaram valores inferiores de T.
It has been proposed in the literature that, in humans, the response of testosterone to the competition can be modulated by cognitive variables. In this study, we tested the hypothesis that variations in testosterone levels observed after a competition are not so related to its outcome in itself but rather with the way the subject evaluates the event in question, particularly with expectations about the competition. To study this, we manipulated the expectations that a group of female participants, created about the competition and its result. We developed a task in laboratory context, which enabled us the manipulation of their expectations. Thus, the participants were distributed into two artificial groups and were instructed with a false feedback that shifted the expectations. In this way, the data collected feature information about participants that have lost or won, in situations of confirmation of expectations or violation of expectations. Therefore, we placed the hypothesis that the testosterone response would be more expressive in participants that won compared with the defeated participants, according to the biosocial model, and we expected a greater amplification of this response when expectations were violated. In fact, the last prediction was confirmed,…
Advisors/Committee Members: Oliveira, Rui Filipe.
Subjects/Keywords: Appraisal; Testosterona; Expectativas; Competição; Testosterone; Expectations; Competition
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Cavalheiro, . A. S. S. (2014). Efeito da violação de expectativas no comportamento e na resposta de testosterona à competição. (Thesis). ISPA. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ispa.pt:10400.12/3601
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Cavalheiro, Ana Sofia Silva. “Efeito da violação de expectativas no comportamento e na resposta de testosterona à competição.” 2014. Thesis, ISPA. Accessed February 27, 2021.
http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ispa.pt:10400.12/3601.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Cavalheiro, Ana Sofia Silva. “Efeito da violação de expectativas no comportamento e na resposta de testosterona à competição.” 2014. Web. 27 Feb 2021.
Vancouver:
Cavalheiro ASS. Efeito da violação de expectativas no comportamento e na resposta de testosterona à competição. [Internet] [Thesis]. ISPA; 2014. [cited 2021 Feb 27].
Available from: http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ispa.pt:10400.12/3601.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Cavalheiro ASS. Efeito da violação de expectativas no comportamento e na resposta de testosterona à competição. [Thesis]. ISPA; 2014. Available from: http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ispa.pt:10400.12/3601
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Rochester
25.
Chen, Zhuoxun.
Identification of Molecular Determinants of
Testosterone-associated Angiogenesis and Neuronal Survival in Adult
Songbird Forebrain.
Degree: PhD, 2012, University of Rochester
URL: http://hdl.handle.net/1802/21371
► The HVC of the adult songbird forebrain undergoes gonadal steroid-mediated survival of new neurons throughout life. Angiogenesis and neuronal recruitment are serially and causally linked…
(more)
▼ The HVC of the adult songbird forebrain undergoes
gonadal steroid-mediated survival of new neurons throughout life.
Angiogenesis and neuronal recruitment are serially and causally
linked in this process, such that testosterone-induced angiogenesis
is necessary for neuronal recruitment. To better understand the
contribution of testosterone-induced transcriptional programs to
this adult neuronal recruitment, we assessed the effects of
androgen exposure on gene expression in the adult canary HVC. We
first generated and sequenced a library of cDNAs derived from
testosterone-treated adult female and male canary HVCs. We then
used these sequences to establish two microarray platforms – a
spotted cDNA array and a high-density oligonucleotide microarray.
Using the higher quality high-density oligonucleotide array, we
profiled the mRNAs of laser capture microdissected HVC sections,
derived from testosterone-treated female canaries killed at varying
time-points after androgen treatment. This analysis revealed
>1000 probe sets that were regulated by testosterone; gene
ontology analysis indicated strong differential regulation of genes
associated with neuronal survival, while pathway analysis revealed
strong differential expression of genes involved in nitric oxide
signaling. In situ hybridization (ISH) confirmed that NRGN, RGS4,
PPP3CA and CAMK2B mRNA were highly differentially expressed in HVC,
whereas PLCB1 mRNA was diminished. Real-time quantitative PCR
analysis confirmed that testosterone induced HVC RGS4 mRNA
expression, but suppressed HVC NRGN, calcineurin/PPP3CA and CAMK2B.
This pattern of regulation suggests that the nitric oxide
regulatory pathways are critically involved in the androgenic
modulation of cellular plasticity in the adult HVC, since this set
of transcripts is highly associated with NO synthesis and
signaling. In addition, we noted that the angiogenic modulators
CRHBP and ADD3 were selectively enriched in the HVC; ISH then
revealed that CRHBP mRNA expression was stimulated by testosterone
specifically in HVC interneurons, while RGS4 was expressed in a
complementary fashion in HVC excitatory projection neurons.
Together, our transcriptional data suggest that HVC interneurons
may subserve a regulatory role in testosterone-dependent
angiogenesis, which may in turn govern HVC neuronal recruitment
through NO-modulatory pathways.
Subjects/Keywords: Neurogenesis; Angiogenesis; Songbird; Testosterone; Neuronal Survival
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Chen, Z. (2012). Identification of Molecular Determinants of
Testosterone-associated Angiogenesis and Neuronal Survival in Adult
Songbird Forebrain. (Doctoral Dissertation). University of Rochester. Retrieved from http://hdl.handle.net/1802/21371
Chicago Manual of Style (16th Edition):
Chen, Zhuoxun. “Identification of Molecular Determinants of
Testosterone-associated Angiogenesis and Neuronal Survival in Adult
Songbird Forebrain.” 2012. Doctoral Dissertation, University of Rochester. Accessed February 27, 2021.
http://hdl.handle.net/1802/21371.
MLA Handbook (7th Edition):
Chen, Zhuoxun. “Identification of Molecular Determinants of
Testosterone-associated Angiogenesis and Neuronal Survival in Adult
Songbird Forebrain.” 2012. Web. 27 Feb 2021.
Vancouver:
Chen Z. Identification of Molecular Determinants of
Testosterone-associated Angiogenesis and Neuronal Survival in Adult
Songbird Forebrain. [Internet] [Doctoral dissertation]. University of Rochester; 2012. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/1802/21371.
Council of Science Editors:
Chen Z. Identification of Molecular Determinants of
Testosterone-associated Angiogenesis and Neuronal Survival in Adult
Songbird Forebrain. [Doctoral Dissertation]. University of Rochester; 2012. Available from: http://hdl.handle.net/1802/21371
26.
Arruda, Ademir Felipe Schultz de.
Territorialidade e nível do adversário: efeitos nas respostas hormonais e comportamentais em jogadores de basquetebol.
Degree: Mestrado, Estudos do Esporte, 2014, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/39/39134/tde-25062014-074945/
;
► O objetivo da presente dissertação foi investigar o efeito da territorialidade e do nível do adversário nas respostas hormonais e comportamentais de jogadores de basquetebol.…
(more)
▼ O objetivo da presente dissertação foi investigar o efeito da territorialidade e do nível do adversário nas respostas hormonais e comportamentais de jogadores de basquetebol. Para tanto, foram realizados dois estudos. No primeiro, investigou-se o efeito da territorialidade nas respostas hormonais e comportamentais decorrentes de jogos oficiais de basquetebol. Dezoito jogadores, do sexo masculino, de duas equipes da categoria sub-19 (ranqueadas em primeiro e segundo lugar na competição) foram avaliados. As equipes jogaram entre si e, portanto, cada equipe realizou um jogo ëm casaë um jogo \"fora de casa\". Amostras de saliva foram coletadas antes e após as duas partidas, para análise dos hormônios testosterona (T) e cortisol (C). Antes do aquecimento, os atletas responderam um questionário de ansiedade pré-competitiva, (Competitive State Anxiety Inventory-2; CSAI-2), e 30 minutos após a partida, classificaram a magnitude do esforço através do método da percepção subjetiva de esforço da sessão (PSE da sessão). A concentração de T PRÉ-jogo foi maior na condição \"casa(̈versus \"fora de casa\"); verificou-se um aumento da concentração de T e C do momento PRÉ- para o PÓS-jogo, independentemente do local do jogo; correlações significantes foram apresentadas entre as respostas hormonais e comportamentais. Esses resultados sugerem a ocorrência do fenômeno da territorialidade, e confirmam que a competição é um evento estressor capaz de alterar a concentração hormonal. No segundo estudo, a influência do nível do adversário nas respostas hormonais e comportamentais de jogadores de basquetebol foi investigada. Dez atletas de uma equipe sub-19 foram avaliados em três jogos oficiais distintos e em uma sessão de treinamento (ST). Em cada um dos jogos oficiais, a equipe enfrentou adversários de diferentes níveis de qualificação, a saber: jogo fácil (JF), jogo médio (JM) e jogo difícil (JD). A classificação do nível do adversário foi realizada por um membro da comissão técnica no início da temporada e monitorada de acordo com a posição de cada uma das equipes durante o campeonato. Foram realizadas coletas de saliva antes e após as quatro condições (três jogos e uma sessão de treinamento) para análise da concentração de T e C. Antes do aquecimento, em todas as condições, os jogadores responderam o questionário CSAI-2 e, aproximadamente 30 minutos após o jogo, responderam a PSE da sessão. A concentração de T aumentou de PRÉ para PÓS no ST e JD; a concentração de T PRÉ-JD foi maior em relação a situação PRÉ-ST. A concentração de C aumentou de PRÉ para PÓS em ST, JM e JD, e a concentração C PRÉ- e PÓS-JD foi maior quando comparada aos mesmos momentos na ST. As ansiedades somática e cognitiva se mostraram maiores no JM e JD em relação ao JF. A autoconfiança foi maior na ST quando comparado com o JM e JD. A PSE da sessão foi maior nos JM e JD em relação à ST. Os resultados do presente estudo indicam que jogos oficiais contra adversários de diferentes níveis podem promover diferentes respostas hormonais e perceptuais
The aim of…
Advisors/Committee Members: Moreira, Alexandre.
Subjects/Keywords: Ansiedade; Anxiety; Estresse; Stress; Testosterona; Testosterone
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Arruda, A. F. S. d. (2014). Territorialidade e nível do adversário: efeitos nas respostas hormonais e comportamentais em jogadores de basquetebol. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/39/39134/tde-25062014-074945/ ;
Chicago Manual of Style (16th Edition):
Arruda, Ademir Felipe Schultz de. “Territorialidade e nível do adversário: efeitos nas respostas hormonais e comportamentais em jogadores de basquetebol.” 2014. Masters Thesis, University of São Paulo. Accessed February 27, 2021.
http://www.teses.usp.br/teses/disponiveis/39/39134/tde-25062014-074945/ ;.
MLA Handbook (7th Edition):
Arruda, Ademir Felipe Schultz de. “Territorialidade e nível do adversário: efeitos nas respostas hormonais e comportamentais em jogadores de basquetebol.” 2014. Web. 27 Feb 2021.
Vancouver:
Arruda AFSd. Territorialidade e nível do adversário: efeitos nas respostas hormonais e comportamentais em jogadores de basquetebol. [Internet] [Masters thesis]. University of São Paulo; 2014. [cited 2021 Feb 27].
Available from: http://www.teses.usp.br/teses/disponiveis/39/39134/tde-25062014-074945/ ;.
Council of Science Editors:
Arruda AFSd. Territorialidade e nível do adversário: efeitos nas respostas hormonais e comportamentais em jogadores de basquetebol. [Masters Thesis]. University of São Paulo; 2014. Available from: http://www.teses.usp.br/teses/disponiveis/39/39134/tde-25062014-074945/ ;

Universidade Estadual de Campinas
27.
Silva, Elcio Dias, 1951-.
Goserelina versus leuprolide na castração química de pacientes com câncer prostático = Goserelin versus leuprolide in the chemical castration of patients with prostate cancer: Goserelin versus leuprolide in the chemical castration of patients with prostate cancer.
Degree: 2012, Universidade Estadual de Campinas
URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/312273
► Abstract: Purpose: to evaluate the relative efficiency of leuprolide 3.75 mg, leuprolide 7.5 mg, and goserelin 3.6 mg in relation to the reduction of serum…
(more)
▼ Abstract: Purpose: to evaluate the relative efficiency of leuprolide 3.75 mg, leuprolide 7.5 mg, and goserelin 3.6 mg in relation to the reduction of serum
testosterone, regarding the levels of castration. Methods: we evaluated prospectively 60 randomized patients with advanced prostate carcinoma, with indication for hormone blockade. The patients were divided into 3 groups of 20: Group 1) received leuprolide 3.75 mg; Group 2) received leuprolide 7.5 mg; group 3) received goserelin 3.6 mg. All groups were treated with monthly application of the respective drugs. Results: the patients' ages were similar within the three groups, with a median of 72, 70, and 70 in groups 1, 2, and 3, respectively. Of the patients that received leuprolide 3.75 mg, leuprolide 7.5 mg, and goserelin 3.6 mg, 26.3%, 25%, and 35%, respectively, did not reach castration levels, considering a
testosterone cut of ?50 ng/dl. 68.4%, 30%, and 45%, respectively, did not reach castration levels, considering a
testosterone cut of ?20 ng/dl. Conclusions: There were no statiscally significant differences in the levels of castration when comparing with leuprolide 3.75 mg, leuprolide 7.5 mg, and goserelin 3.6 mg, when comparing the three substances altogether. When compared in groups of two, there was a statiscally significant difference between leuprolide 3.75 mg and leuprolide 7.5 mg, in which the latter presented better results in reaching castration levels, when considered equal or less than 20ng/dl. The importance of this difference, however, must be measured with caution, since the comparison of the three groups simultaneously did not reach the established significance level, even though it came close
Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Matheus, Wagner Eduardo (advisor), Ferreira, Ubirajara, 1956- (coadvisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), Programa de Pós-Graduação em Cirurgia (nameofprogram), Fregonesi, Adriano (committee member), Denardi, Fernando (committee member), Mitre, Anuar Ibrahim (committee member), Castilho, Lísias Nogueira (committee member).
Subjects/Keywords: Próstata - Câncer; Testosterona; Prostate - Cancer; Testosterone
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Silva, Elcio Dias, 1. (2012). Goserelina versus leuprolide na castração química de pacientes com câncer prostático = Goserelin versus leuprolide in the chemical castration of patients with prostate cancer: Goserelin versus leuprolide in the chemical castration of patients with prostate cancer. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/312273
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Silva, Elcio Dias, 1951-. “Goserelina versus leuprolide na castração química de pacientes com câncer prostático = Goserelin versus leuprolide in the chemical castration of patients with prostate cancer: Goserelin versus leuprolide in the chemical castration of patients with prostate cancer.” 2012. Thesis, Universidade Estadual de Campinas. Accessed February 27, 2021.
http://repositorio.unicamp.br/jspui/handle/REPOSIP/312273.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Silva, Elcio Dias, 1951-. “Goserelina versus leuprolide na castração química de pacientes com câncer prostático = Goserelin versus leuprolide in the chemical castration of patients with prostate cancer: Goserelin versus leuprolide in the chemical castration of patients with prostate cancer.” 2012. Web. 27 Feb 2021.
Vancouver:
Silva, Elcio Dias 1. Goserelina versus leuprolide na castração química de pacientes com câncer prostático = Goserelin versus leuprolide in the chemical castration of patients with prostate cancer: Goserelin versus leuprolide in the chemical castration of patients with prostate cancer. [Internet] [Thesis]. Universidade Estadual de Campinas; 2012. [cited 2021 Feb 27].
Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/312273.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Silva, Elcio Dias 1. Goserelina versus leuprolide na castração química de pacientes com câncer prostático = Goserelin versus leuprolide in the chemical castration of patients with prostate cancer: Goserelin versus leuprolide in the chemical castration of patients with prostate cancer. [Thesis]. Universidade Estadual de Campinas; 2012. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/312273
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

McMaster University
28.
Morton, Robert William.
Resistance exercise-induced muscle hypertrophy.
Degree: PhD, 2019, McMaster University
URL: http://hdl.handle.net/11375/24767
► Resistance exercise training (RET) can lead to muscle hypertrophy; however, the relative contribution that exogenous (protein supplementation and specific training variables) versus endogenous (biology inherent…
(more)
▼ Resistance exercise training (RET) can lead to muscle hypertrophy; however, the relative contribution that exogenous (protein supplementation and specific training variables) versus endogenous (biology inherent to the individual) factors have on RET-induced muscle hypertrophy is controversial. In Study 1, we provided an evidence-based conclusion that protein supplementation during periods of RET results in a small but statistically significant increase in RET-induced muscle hypertrophy. In Study 2, we corroborate previous research and observed that the amount of mass lifted per repetition (load) did not determine RET-induced muscle hypertrophy in resistance-trained men when RET was performed to volitional fatigue. In Study 4, we observed similar muscle fibre activation following resistance exercise with lighter versus heavier loads when both were lifted until volitional fatigue. In Studies 2 and 3, we observed no relationship between circulating anabolic hormones (e.g., testosterone) and RET-induced muscle hypertrophy. Nonetheless, in Study 3, we found significantly greater muscle androgen receptor content in the top versus the bottom quintile of respondents for muscle hypertrophy following 12 weeks of RET indicating that androgen receptor content, and not circulating androgen concentration, may be an important determinant of hypertrophy. Finally, in Study 5, we observed that RET-induced muscle hypertrophy was an consistent within an individual (independent of load and limb) but considerably different between participants. Together, these data suggest that the exogenous factors we studied – protein supplementation and load (when RET was performed to volitional fatigue) – had a relatively small influence on RET-induced muscle hypertrophy. In contrast, we found that endogenous variables, such as intramuscular androgen receptor content and likely other genetic influences, appear to contribute more to the significant heterogeneity seen in RET-induced muscle hypertrophy. Future research in this area should prioritize understanding the biology that underpins the individual variability in RET-induced muscle hypertrophy.
Thesis
Doctor of Philosophy (PhD)
Resistance exercise training (RET) increases muscle size (hypertrophy); however, the relative influence that protein supplementation, specific training variables, and individual (genetic) variation have on the RET-induced hypertrophy is controversial and largely unknown. Broadly, data in this thesis show that protein supplementation slightly augments RET-induced hypertrophy, and that the magnitude of RET-induced hypertrophy may be related to the number of androgen (e.g., testosterone) receptors inside an individual’s muscle. In contrast, we found that neither load nor hormones affect RET-induced hypertrophy. Interestingly, data in this thesis also show that RET-induced hypertrophy is consistent within an individual but varies considerably between people, which illustrates the greater influence that individual variation has on RET-induced hypertrophy. We conclude…
Advisors/Committee Members: Phillips, Stuart, Kinesiology.
Subjects/Keywords: resistance exercise; skeletal muscle; hypertrophy; strength; testosterone
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APA ·
Chicago ·
MLA ·
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APA (6th Edition):
Morton, R. W. (2019). Resistance exercise-induced muscle hypertrophy. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/24767
Chicago Manual of Style (16th Edition):
Morton, Robert William. “Resistance exercise-induced muscle hypertrophy.” 2019. Doctoral Dissertation, McMaster University. Accessed February 27, 2021.
http://hdl.handle.net/11375/24767.
MLA Handbook (7th Edition):
Morton, Robert William. “Resistance exercise-induced muscle hypertrophy.” 2019. Web. 27 Feb 2021.
Vancouver:
Morton RW. Resistance exercise-induced muscle hypertrophy. [Internet] [Doctoral dissertation]. McMaster University; 2019. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/11375/24767.
Council of Science Editors:
Morton RW. Resistance exercise-induced muscle hypertrophy. [Doctoral Dissertation]. McMaster University; 2019. Available from: http://hdl.handle.net/11375/24767

Leiden University
29.
Selten, Ellen.
Hormonen en gedrag bij jongens met hoogfunctionerend autisme.
Degree: 2013, Leiden University
URL: http://hdl.handle.net/1887/25813
► Abstract Background. This study examines the relationship between hormonal parameters of puberty development and fetal testosterone levels with the presence of autistic symptoms, especially the…
(more)
▼ Abstract
Background. This study examines the relationship between hormonal parameters of puberty development and fetal
testosterone levels with the presence of autistic symptoms, especially the deficits in cognitive empathy in boys with high functioning autism (HFA) between nine and nineteen years old. According to several theories, hormones are involved in the etiology and behavioral characteristics of ASD in later life, such as problems with cognitive empathy. Method. In 45 HFA boys and 41 non-clinical boys, the degree of autistic symptoms is defined by the ADI-R and the SRS, and cognitive empathy is determined by the SCVT. Saliva samples are taken to determine
testosterone, DHEA and estradiol levels. The fetal
testosterone level was determined using the 2D:4D ratio. Results. Levels of fetal
testosterone were significantly higher in HFA boys compared to non- clinical controls. Also, there is a connection between the fetal
testosterone levels and cognitive deficits in cognitive empathy on the scale ‘discriminating perspectives’ in HFA boys. Higher scores are associated with higher fetal
testosterone levels. Further research should incorporate the influence of mediating genes and neural structures, and should investigate the influence of hormones over a longer period, to assess the influence of hormones during social development.
Advisors/Committee Members: Rijn, Sophie van (advisor).
Subjects/Keywords: HFA; puberty hormones; prenatal testosterone; cognitive empathy
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Selten, E. (2013). Hormonen en gedrag bij jongens met hoogfunctionerend autisme. (Masters Thesis). Leiden University. Retrieved from http://hdl.handle.net/1887/25813
Chicago Manual of Style (16th Edition):
Selten, Ellen. “Hormonen en gedrag bij jongens met hoogfunctionerend autisme.” 2013. Masters Thesis, Leiden University. Accessed February 27, 2021.
http://hdl.handle.net/1887/25813.
MLA Handbook (7th Edition):
Selten, Ellen. “Hormonen en gedrag bij jongens met hoogfunctionerend autisme.” 2013. Web. 27 Feb 2021.
Vancouver:
Selten E. Hormonen en gedrag bij jongens met hoogfunctionerend autisme. [Internet] [Masters thesis]. Leiden University; 2013. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/1887/25813.
Council of Science Editors:
Selten E. Hormonen en gedrag bij jongens met hoogfunctionerend autisme. [Masters Thesis]. Leiden University; 2013. Available from: http://hdl.handle.net/1887/25813

North Carolina State University
30.
Sisk, Dana Stanley.
Reproductive Gene Expression in Male Sus scrofa: An examination of the differential gene expression of Divergent Testosterone selection and development of a Ribonucleic Acid extraction protocol from whole Porcine Spermatozoa.
Degree: MS, Animal Science, 2009, North Carolina State University
URL: http://www.lib.ncsu.edu/resolver/1840.16/41
► The ability to characterize and enhance market traits in livestock has facilitated a greater interest in determining the genetic tool kit available for manipulation. In…
(more)
▼ The ability to characterize and enhance market traits in livestock has facilitated a greater interest in determining the genetic tool kit available for manipulation. In swine, using new approaches in genomics, such as microarray analysis and biological pathway analysis, we can show genes up and down regulated in a variety of processes and conditions. To this end, we identify the genes, pathways, and disease biomarkers affected by divergent selection of
testosterone in boars. Testicular samples were taken from boars at 0, 30, 120, 150, and 180 days of age for lines of high (HT) and low
testosterone (LT). Evidence that many of the differences in gene expression were at the pubertal period of 150 days led to a subsequent microarray study of the 150 day HT and LT animals. Microarray studies were followed by validation with real-time RT-PCR of 11 genes and extensive GeneGo pathway analysis (Metacore) of differentially expressed genes. While increased
testosterone has long been associated with increased growth rates, we now have supporting genomic evidence of the genes and pathways up-regulated and down-regulated in these lines. To this end, this study has identified several disease biomarkers that may require further investigation and biological pathways associated with growth and metabolism that allow the recommendation of selective breeding for high
testosterone to increase lean growth traits.
The genetic blueprint contained in the spermatozoan transcriptome can also illuminate key issues in swine reproduction. By developing a procedure for effective RNA extraction of boar spermatozoa we are one step closer to elucidating the porcine sperm transcriptome and the genes implicated in growth and fertility. A viable protocol was developed to handle the complexities of large scale extraction of RNA from porcine semen utilizing an RNA carrier and Dnase treatment. This protocol was validated with PCR amplification of Sus scrofa prm1 in order to provide evidence of a successful RNA extraction from sperm.
Advisors/Committee Members: Melissa S. Ashwell, Committee Chair (advisor), William L. Flowers, Committee Member (advisor), Alison A. Motsinger-Reif, Committee Member (advisor).
Subjects/Keywords: sperm; semen; testosterone; testis; growth; swine; RNA
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Sisk, D. S. (2009). Reproductive Gene Expression in Male Sus scrofa: An examination of the differential gene expression of Divergent Testosterone selection and development of a Ribonucleic Acid extraction protocol from whole Porcine Spermatozoa. (Thesis). North Carolina State University. Retrieved from http://www.lib.ncsu.edu/resolver/1840.16/41
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Sisk, Dana Stanley. “Reproductive Gene Expression in Male Sus scrofa: An examination of the differential gene expression of Divergent Testosterone selection and development of a Ribonucleic Acid extraction protocol from whole Porcine Spermatozoa.” 2009. Thesis, North Carolina State University. Accessed February 27, 2021.
http://www.lib.ncsu.edu/resolver/1840.16/41.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Sisk, Dana Stanley. “Reproductive Gene Expression in Male Sus scrofa: An examination of the differential gene expression of Divergent Testosterone selection and development of a Ribonucleic Acid extraction protocol from whole Porcine Spermatozoa.” 2009. Web. 27 Feb 2021.
Vancouver:
Sisk DS. Reproductive Gene Expression in Male Sus scrofa: An examination of the differential gene expression of Divergent Testosterone selection and development of a Ribonucleic Acid extraction protocol from whole Porcine Spermatozoa. [Internet] [Thesis]. North Carolina State University; 2009. [cited 2021 Feb 27].
Available from: http://www.lib.ncsu.edu/resolver/1840.16/41.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Sisk DS. Reproductive Gene Expression in Male Sus scrofa: An examination of the differential gene expression of Divergent Testosterone selection and development of a Ribonucleic Acid extraction protocol from whole Porcine Spermatozoa. [Thesis]. North Carolina State University; 2009. Available from: http://www.lib.ncsu.edu/resolver/1840.16/41
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
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