subject:(tandem)

1. Kotowich, Steven. Tandem cyclization/ sigmatropic rearrangement of a-3-nitropropyl-1-cyclohexene-1-methanol derivatives.

Degree: 2012, Drexel University

URL: http://hdl.handle.net/1860/3794

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In this investigation the focus is on the formation of nitro compounds via sigmatropic rearrangement of 0-allyl nitronic esters. a-[3-Nitropropyl]-1-cyclohexene-1-methanol and two derivatives were prepared… (more)

Subjects/Keywords: Chemistry; Sigmatropic rearrangement; Tandem cyclization

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APA (6^th Edition):

Kotowich, S. (2012). Tandem cyclization/ sigmatropic rearrangement of a-3-nitropropyl-1-cyclohexene-1-methanol derivatives. (Thesis). Drexel University. Retrieved from http://hdl.handle.net/1860/3794

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kotowich, Steven. “Tandem cyclization/ sigmatropic rearrangement of a-3-nitropropyl-1-cyclohexene-1-methanol derivatives.” 2012. Thesis, Drexel University. Accessed April 20, 2021. http://hdl.handle.net/1860/3794.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kotowich, Steven. “Tandem cyclization/ sigmatropic rearrangement of a-3-nitropropyl-1-cyclohexene-1-methanol derivatives.” 2012. Web. 20 Apr 2021.

Vancouver:

Kotowich S. Tandem cyclization/ sigmatropic rearrangement of a-3-nitropropyl-1-cyclohexene-1-methanol derivatives. [Internet] [Thesis]. Drexel University; 2012. [cited 2021 Apr 20]. Available from: http://hdl.handle.net/1860/3794.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kotowich S. Tandem cyclization/ sigmatropic rearrangement of a-3-nitropropyl-1-cyclohexene-1-methanol derivatives. [Thesis]. Drexel University; 2012. Available from: http://hdl.handle.net/1860/3794

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Penn State University

2. Kren, Nancy Porterfield. Characterization of Functional Regions of OGFr.

Degree: 2015, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/26247

► The Opioid Growth Factor (OGF)-OGF receptor (OGFr) axis is present and tonically active in animal and human cancer cell lines, as well as human tumors.… (more)

▼ The Opioid Growth Factor (OGF)-OGF receptor (OGFr) axis is present and tonically active in animal and human cancer cell lines, as well as human tumors. The OGF-OGFr pathway tonically mediates cell replication in cancer, with OGF serving as an autocrine-produced inhibitory pentapeptide. The inhibitory action of OGF on cell replication requires that OGF bind to OGFr, traffic into the nucleus to upregulate inhibitory kinases, p16 and p21 that act to stall the progression from G1-S phase of the cell cycle. Little is currently known about the functional regions required for this function. To begin to characterize the functional regions of OGFr, mutations in OGFr identified in cancer samples were characterized. Two mutations identified in cancer samples, S378I and R444H, were characterized with respect to their effects on localization of the receptor, as well as their ability to alter DNA synthesis. R444H demonstrated a significant decrease in the nuclear/cytoplasmic ratio while S378I showed no change. Both mutations demonstrated a loss of response to OGF and the long-acting opioid receptor antagonist naltrexone (NTX) in growth assays. R444H also demonstrated a loss of inhibition in DNA synthesis, while S378I showed no significant change compared to OGFr in the BrdU assay. These data demonstrate that cancer mutations such as R444H are capable of altering the inhibitory function of OGFr, while other mutations such as S378I may be capable of altering the response to the ligand OGF or the antagonist NTX. These data contribute to the understanding of the functionally required regions of OGFr and warrant further characterization of mutations identified in cancer samples.OGFr has three nuclear localization signals (NLS) that have previously been characterized. OGFr requires at least two of the three NLSs for entry into the nucleus and for inhibition of cell proliferation. When NLSs were mutated, OGFr was excluded from the nucleus and proliferation inhibition was lost. The nuclear export of OGFr is currently unknown. In this study, endogenous OGFr, as well as exogenously expressed OGFr-EGFP, demonstrated significant nuclear accumulation in response to leptomycin B (LMB), an inhibitor of CRM1 dependent nuclear export, suggesting OGFr is exported in a CRM1 dependent manner. One leucine rich sequence fitting the consensus sequence for nuclear export signals (NES) was identified. To better characterize this sequence, the associated leucines, L217 L220 L223 and L225, were mutated to alanine in isolation as well as in combinations. All of the mutations resulted in decreased nuclear accumulation. In support of decreased nuclear localization, subNES demonstrated a loss of inhibition. When the proposed NES was fused to EGFP, NES-EGFP, it responded to LMB, indicating this sequence is capable of functioning as an export signal in isolation. To investigate why the sequence functions differently in isolation than in the context of the full-length protein, the localization of subNES was evaluated in the presence of MG132, a potent inhibitor of… Advisors/Committee Members: Patricia McLaughlin, Dissertation Advisor/Co-Advisor, Michael Verderame, Committee Member, Ira Joseph Ropson, Committee Member, Lisa M Shantz, Committee Member, Samuel Shaomin Zhang, Committee Member.

Subjects/Keywords: OGFr; NES; Tandem Repeats

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APA (6^th Edition):

Kren, N. P. (2015). Characterization of Functional Regions of OGFr. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/26247

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kren, Nancy Porterfield. “Characterization of Functional Regions of OGFr.” 2015. Thesis, Penn State University. Accessed April 20, 2021. https://submit-etda.libraries.psu.edu/catalog/26247.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kren, Nancy Porterfield. “Characterization of Functional Regions of OGFr.” 2015. Web. 20 Apr 2021.

Vancouver:

Kren NP. Characterization of Functional Regions of OGFr. [Internet] [Thesis]. Penn State University; 2015. [cited 2021 Apr 20]. Available from: https://submit-etda.libraries.psu.edu/catalog/26247.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kren NP. Characterization of Functional Regions of OGFr. [Thesis]. Penn State University; 2015. Available from: https://submit-etda.libraries.psu.edu/catalog/26247

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Thorwaldsson, Henrik. Development of asphalt removing tool for a tandem roller.

Degree: 2014, , Department of Mechanical Engineering

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:bth-2601

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This master thesis have been done to come up with different concepts that could solve problems that is connected to vibrations in tandem rollers.… (more)

Subjects/Keywords: Scraper; asphalt; tandem roller

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APA (6^th Edition):

Thorwaldsson, H. (2014). Development of asphalt removing tool for a tandem roller. (Thesis). , Department of Mechanical Engineering. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:bth-2601

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Thorwaldsson, Henrik. “Development of asphalt removing tool for a tandem roller.” 2014. Thesis, , Department of Mechanical Engineering. Accessed April 20, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-2601.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Thorwaldsson, Henrik. “Development of asphalt removing tool for a tandem roller.” 2014. Web. 20 Apr 2021.

Vancouver:

Thorwaldsson H. Development of asphalt removing tool for a tandem roller. [Internet] [Thesis]. , Department of Mechanical Engineering; 2014. [cited 2021 Apr 20]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:bth-2601.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Thorwaldsson H. Development of asphalt removing tool for a tandem roller. [Thesis]. , Department of Mechanical Engineering; 2014. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:bth-2601

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Minnesota

4. Bigert, Matthew. Selectivity Optimization in Tandem Column Liquid Chromatography Using the Eluent Composition as the Tuning Variable.

Degree: MS, Chemistry, 2018, University of Minnesota

URL: http://hdl.handle.net/11299/201018

► Clearly, in typical separations in HPLC, selectivity is the most important variable for improving resolution and the optimization of selectivity is the primary focus of… (more)

▼ Clearly, in typical separations in HPLC, selectivity is the most important variable for improving resolution and the optimization of selectivity is the primary focus of most method development effort in reversed-phase liquid chromatography (RPLC). We have developed a family of novel techniques in which two columns with markedly different chromatographic selectivities are combined in tandem. One then uses another chromatographic variable (e.g. temperature, flow rate, eluent composition) which has different values for the two columns to continuously “tune” the selectivity. We call this family of techniques XT2C, meaning that the variable X (temperature, etc.) is used to continuously tune the combined selectivity of the tandem columns. By serially coupling the columns, our approach eliminates the common “selectivity discontinuity” problem encountered by analysts when the type of column used is changed. Previously, we utilized the thermally tuned tandem column (T3C) concept in which selectivity was adjusted by independently tuning the two column temperatures. The primary difference between the experimental setup for T3C and XT2C is that a second pump and static micro-mixer are placed between the two columns. In this study, we describe the eluent tuned tandem column concept in which selectivity is continuously tuned by independently controlling the eluent composition of each column. When the percent organic modifier in the eluent (%B) is adjusted, the concept is denoted “solvent tuned tandem column (ST2C)”. Likewise, when the ionic strength (buffer concentration) is tuned, the concept is referred to as ionic strength tuned tandem column (IT2C). The objective of the present study is to evaluate the applicability of IT2C and ST2C to mixtures of ionic and non-ionic analytes, respectively. We also describe the use of a simple computer assisted optimization strategy based on the window diagram method. This strategy allows for XT2C optimization based on only four to six initial data acquisition runs. ST2C and IT2C are comparable in terms of chromatographic performance to T3C and provide flexibility in optimizing selectivity but do not require thermally stable columns.

Subjects/Keywords: Eluent; HPLC; Selectivity; Tandem

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APA (6^th Edition):

Bigert, M. (2018). Selectivity Optimization in Tandem Column Liquid Chromatography Using the Eluent Composition as the Tuning Variable. (Masters Thesis). University of Minnesota. Retrieved from http://hdl.handle.net/11299/201018

Chicago Manual of Style (16^th Edition):

Bigert, Matthew. “Selectivity Optimization in Tandem Column Liquid Chromatography Using the Eluent Composition as the Tuning Variable.” 2018. Masters Thesis, University of Minnesota. Accessed April 20, 2021. http://hdl.handle.net/11299/201018.

MLA Handbook (7^th Edition):

Bigert, Matthew. “Selectivity Optimization in Tandem Column Liquid Chromatography Using the Eluent Composition as the Tuning Variable.” 2018. Web. 20 Apr 2021.

Vancouver:

Bigert M. Selectivity Optimization in Tandem Column Liquid Chromatography Using the Eluent Composition as the Tuning Variable. [Internet] [Masters thesis]. University of Minnesota; 2018. [cited 2021 Apr 20]. Available from: http://hdl.handle.net/11299/201018.

Council of Science Editors:

Bigert M. Selectivity Optimization in Tandem Column Liquid Chromatography Using the Eluent Composition as the Tuning Variable. [Masters Thesis]. University of Minnesota; 2018. Available from: http://hdl.handle.net/11299/201018

University of New South Wales

5. Timerbulatova, Marina Gazinurovna. Bimetallic complexes as catalysts for tandem reactions.

Degree: Chemistry, 2013, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/52722 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11395/SOURCE01?view=true

► This thesis consists of two parts. The first part describes the investigation of bimetallic cooperativity for known Rh(I) and Ir(I) homobimetallic complexes containing bis(1-pyrazolyl)methane (bpm)… (more)

▼ This thesis consists of two parts. The first part describes the investigation of bimetallic cooperativity for known Rh(I) and Ir(I) homobimetallic complexes containing bis(1-pyrazolyl)methane (bpm) motifs and weakly coordinating tetrakis[3,5-bis (trifluoromethyl)phenyl]borate (BArF4-) anions using DFT methods. The second part describes synthesis of novel Ir(III) and Rh(III) monometallic complexes with N-heterocyclic carbenes-nitrogen (NHC-N) donor ligands, 1,2,3,4,5-pentamethylcyclopentadienyl (Cp*) co-ligands, and weakly coordinating tetraphenylborate (BPh4-) anions. It also describes the development of a strategy for the synthesis of novel heterobimetallic Rh(III) and Ir(I) complexes with a stable heterobimetallic structure based on monometallic complexes synthesized during the course of this work; the synthesis of the heterobimetallic complexes; and the investigation of their catalytic activity for sequential C-C and C-N bond formation.Based on DFT calculations, which have been conducted on a number of structures containing the bpm fragment, the best functional and basis set for the description of Rh(I) and Ir(I) homobimetallic complexes was established to be bp86 with a SDD basis set for metals and 6-31G(d, p) for other atoms.It was established that bimetallic structures with bpm motifs can accommodate a significant number of possible conformations and each of these conformations was found to be accessible at the temperature of the catalytic dihydroalkoxylation reaction. The distance between the two metal centers varied significantly from one conformation to another. The Boltzmann distribution of the particles between different conformations was not even and, therefore, the contribution by some conformations to the catalytic process was expected to be more significant than others. This allowed us to calculate the average metal-metal distances based on the statistical population of the energy levels corresponding to the different conformations of the bimetallic complexes held on a series of scaffolds. The average metal-metal distance was found to vary according to the nature of the linking scaffold in the order m-benzene > p-benzene > anthracene >xanthene. The catalytic activity of those complexes in the dihydroalkoxylation reaction was greatest for anthracene linked complex which corresponded to an average metal-metal distance of 5.95 Å. Based on this, two catalytic intermediates were proposed.IIINo significant impact on the structure of the complexes was observed when Rh(I) was substituted with Ir(I). Therefore, the difference in catalytic activity observed for Ir(I) and Rh(I) complexes was found to be the result of the unique properties of these metals, rather than the structure of the bimetallic complexes.A series of chelating N-heterocyclic carbene-triazole (CaT) donor ligands 4.1 - 4.4 containing various substituents on both the carbene and triazole donor groups were synthesized. Seven novel Ir(III) and Rh(III) complexes 4.5 - 4.11 with these ligands, 1,2,3,4,5-pentamethylcyclopentadienyl (Cp*) as a… Advisors/Committee Members: Messerle, Barbara, Chemistry, Faculty of Science, UNSW, Edwards , Gavin, Chemistry, Faculty of Science, UNSW.

Subjects/Keywords: Tandem Reactions; Bimetallic Complexes; Catalyst

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APA (6^th Edition):

Timerbulatova, M. G. (2013). Bimetallic complexes as catalysts for tandem reactions. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/52722 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11395/SOURCE01?view=true

Chicago Manual of Style (16^th Edition):

Timerbulatova, Marina Gazinurovna. “Bimetallic complexes as catalysts for tandem reactions.” 2013. Doctoral Dissertation, University of New South Wales. Accessed April 20, 2021. http://handle.unsw.edu.au/1959.4/52722 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11395/SOURCE01?view=true.

MLA Handbook (7^th Edition):

Timerbulatova, Marina Gazinurovna. “Bimetallic complexes as catalysts for tandem reactions.” 2013. Web. 20 Apr 2021.

Vancouver:

Timerbulatova MG. Bimetallic complexes as catalysts for tandem reactions. [Internet] [Doctoral dissertation]. University of New South Wales; 2013. [cited 2021 Apr 20]. Available from: http://handle.unsw.edu.au/1959.4/52722 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11395/SOURCE01?view=true.

Council of Science Editors:

Timerbulatova MG. Bimetallic complexes as catalysts for tandem reactions. [Doctoral Dissertation]. University of New South Wales; 2013. Available from: http://handle.unsw.edu.au/1959.4/52722 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11395/SOURCE01?view=true

University of New South Wales

6. Zhang, Bo. Germanium nanocrystals towards tandem solar cell applications: physics and technology.

Degree: Photovoltaics & Renewable Energy Engineering, 2011, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/51265 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:9946/SOURCE02?view=true

► Germanium nanocrystals (Ge-ncs) embedded in amorphous SiO2 matrix have attracted much attention as a promising material for optoelectronic applications, such as thin film tandem solar… (more)

▼ Germanium nanocrystals (Ge-ncs) embedded in amorphous SiO2 matrix have attracted much attention as a promising material for optoelectronic applications, such as thin film tandem solar cells. The successful implementation of this nanostructure requires the development of fabrication techniques and the understanding of structural, optical and electrical properties of the produced nanocrystals.A comprehensive study of Ge-ncs grown in a superlattice structure is presented to demonstrate the feasibility of the superlattice for controlling nanocrystal size and engineering the electronic band gap of thin films. The structural properties of Ge-ncs were extensively studied by a series of characterization techniques including Raman spectroscopy, X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS). A kinetic model for the crystallization process in a superlattice has been proposed to explain the size control effect. Band gap engineering by tuning the superlattice structure was studied using optical absorption and photoluminescence measurements, and the experimental results were further compared with the results from theoretical calculation. Although a clear shift towards higher energies was observed in the absorption edge and luminescence peak, it remains ambiguous whether this could be attributed to the quantum confinement effect in Ge-ncs.A simple and silicon process-compatible technique is reported for the synthesis of Ge-ncs at temperatures below 400 °C, which is much lower than the typical growth temperatures. The Ge-ncs were found to form only within a temperature window between 350 °C and 420 °C. The underlying growth mechanism can be explained by a competitive process between Volmer-Weber growth and oxidation reaction. This technique has also been shown to be suitable for the fabrication of superlattice structure. Case studies on the stress development and optical absorption properties of the low temperature grown Ge-ncs are presented as well.Thin films composed of Ge-ncs in SiO2 matrix were prepared using the low temperature growth technique and their electrical properties were comprehensively studied. P-type behaviour was observed in the undoped thin films, which is attributed to the hole accumulation in Ge-ncs caused by the acceptor-like surface states. The charge transport is a thermally activated process involving charge hopping from one nanocrystal to its nearest neighbors. The p-type conductivity was further improved by the post-growth rapid thermal annealing and this can be explained by the modification of Ge-ncs’ surface structure and the reduction of defects in SiO2 matrix. The effects of impurities on the electrical conduction properties of Ge-nc thin films were studied as a starting point of future work on making n-type thin films and thereby the homojunction devices. Moreover, the electrical and photovoltaic properties of the heterojunction diodes employing the p-type Ge-nc thin films were… Advisors/Committee Members: Conibeer, Gavin, Photovoltaics & Renewable Energy Engineering, Faculty of Engineering, UNSW, Green, Martin, Photovoltaics & Renewable Energy Engineering, Faculty of Engineering, UNSW, Shrestha, Santosh, Photovoltaics & Renewable Energy Engineering, Faculty of Engineering, UNSW.

Subjects/Keywords: Tandem cell; Nanocrytals; Solar cell

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APA (6^th Edition):

Zhang, B. (2011). Germanium nanocrystals towards tandem solar cell applications: physics and technology. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/51265 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:9946/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Zhang, Bo. “Germanium nanocrystals towards tandem solar cell applications: physics and technology.” 2011. Doctoral Dissertation, University of New South Wales. Accessed April 20, 2021. http://handle.unsw.edu.au/1959.4/51265 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:9946/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Zhang, Bo. “Germanium nanocrystals towards tandem solar cell applications: physics and technology.” 2011. Web. 20 Apr 2021.

Vancouver:

Zhang B. Germanium nanocrystals towards tandem solar cell applications: physics and technology. [Internet] [Doctoral dissertation]. University of New South Wales; 2011. [cited 2021 Apr 20]. Available from: http://handle.unsw.edu.au/1959.4/51265 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:9946/SOURCE02?view=true.

Council of Science Editors:

Zhang B. Germanium nanocrystals towards tandem solar cell applications: physics and technology. [Doctoral Dissertation]. University of New South Wales; 2011. Available from: http://handle.unsw.edu.au/1959.4/51265 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:9946/SOURCE02?view=true

7. Carmichael, Rachael A. One-pot Tandem Diels-Alder/Nazarov Reactions to Generate Advanced Tricyclic Intermediates.

Degree: 2017, University of Nevada – Reno

URL: http://hdl.handle.net/11714/2088

► One-pot multi-component reactions represent efficacious strategies to rapidly obtain complex intermediates applicable in the synthesis of therapeutically germane compounds. Nazarov reactions of aryl vinyl ketones… (more)

▼ One-pot multi-component reactions represent efficacious strategies to rapidly obtain complex intermediates applicable in the synthesis of therapeutically germane compounds. Nazarov reactions of aryl vinyl ketones are viewed as important steps in total synthesis and contribute to expanding the chemist’s synthetic toolbox. Currently, activated substrates or photochemical means are necessary to effect this transformation because the energy barrier is predicted to be relatively high. The stabilizing effect of silyl substituents beta to a carbocation intermediate has been well documented. a) We hypothesized that incorporation of a silyl group into the ynone starting materials may stabilize the reactive intermediates, enabling the aryl Nazarov reaction to proceed even with unactivated substrates. The use of aryl silyl ynones proved successful and as a consequence our group developed a tandem process utilizing the Diels-Alder and Nazarov reactions of aryl ynones to generate carbo- and heterocyclic fused ring systems in good yields. The tandem reactions proceed under Lewis acidic conditions to generate three new carbon-carbon bonds, a quaternary carbon and two stereogenic centers. In order to access a wider range of pharmaceutically important compounds through concise routes, a more versatile technology is needed. The use of diynones as relatively high energy starting materials facilitates multiple carbon-carbon bond formations in a one-pot reaction. With respect to unsymmetrical diynones, regiocontrol of the double bond is accomplished through silane elimination rather than loss of hydrogen, ensuring the formation of one major product. Furthermore, the Diels-Alder cycloaddition occurs preferentially on the silyl substituted alkyne at low temperatures, allowing for a “timed” double Diels-Alder reaction in which two different dienes can be added, generating a highly asymmetric product. Such molecular control permits a significant amount of versatility within the method. b) Our lab has designed and successfully executed a highly modifiable multicomponent reaction, initiating from a double Diels-Alder cycloaddition followed by a Nazarov reaction to furnish the [6-5-6] backbone. This method produces three fused rings evolving from the construction of five new carbon-carbon bonds, quaternary or vicinal quaternary carbons, and stereogenic centers in a one-pot reaction. A diverse array of drug-like scaffolds can be rapidly synthesized through these tandem processes providing a high level of stereo- and regiocontrol in the products. Advisors/Committee Members: Chalifoux, Wesley A. (advisor), Bell, Thomas (committee member), Catalano, Vincent (committee member), Smilanich, Angela (committee member), Cremo, Christine (committee member).

Subjects/Keywords: cascade; Diels-Alder; Nazarov; tandem

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APA (6^th Edition):

Carmichael, R. A. (2017). One-pot Tandem Diels-Alder/Nazarov Reactions to Generate Advanced Tricyclic Intermediates. (Thesis). University of Nevada – Reno. Retrieved from http://hdl.handle.net/11714/2088

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Carmichael, Rachael A. “One-pot Tandem Diels-Alder/Nazarov Reactions to Generate Advanced Tricyclic Intermediates.” 2017. Thesis, University of Nevada – Reno. Accessed April 20, 2021. http://hdl.handle.net/11714/2088.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Carmichael, Rachael A. “One-pot Tandem Diels-Alder/Nazarov Reactions to Generate Advanced Tricyclic Intermediates.” 2017. Web. 20 Apr 2021.

Vancouver:

Carmichael RA. One-pot Tandem Diels-Alder/Nazarov Reactions to Generate Advanced Tricyclic Intermediates. [Internet] [Thesis]. University of Nevada – Reno; 2017. [cited 2021 Apr 20]. Available from: http://hdl.handle.net/11714/2088.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Carmichael RA. One-pot Tandem Diels-Alder/Nazarov Reactions to Generate Advanced Tricyclic Intermediates. [Thesis]. University of Nevada – Reno; 2017. Available from: http://hdl.handle.net/11714/2088

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

8. Schuchardt, Guillaume. Performance et durée de vie des architectures photovoltaïques organiques tandems : Performance and stability of tandem organic photovoltaic.

Degree: Docteur es, Doctorat Sciences Pour l'Ingénieur, 2017, Université Grenoble Alpes (ComUE)

URL: http://www.theses.fr/2017GREAA004

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Le photovoltaïque organique est une technologie pleine de promesses tant ses avantages sont nombreux : flexibilité, légèreté, conformabilité, faible coût de fabrication, etc. Seulement, les… (more)

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Le photovoltaïque organique est une technologie pleine de promesses tant ses avantages sont nombreux : flexibilité, légèreté, conformabilité, faible coût de fabrication, etc. Seulement, les rendements modérés et la durée de vie limitée des dispositifs ralentissent encore son déploiement. L’une des stratégies envisagée à l’augmentation des rendements est l’utilisation d’une architecture tandem qui consiste en la superposition de deux sous-cellules ayant des spectres d’absorption complémentaires. Seulement, aucune étude n’a été faite sur la stabilité de ces dispositifs dans le temps. Ce travail de thèse a donc pour objectif de concevoir des cellules tandems à haut rendement et d’étudier leur durée de vie sous une illumination AM1.5G 1000 W/m².Dans un premier temps, un travail d’optimisation en cellule simple a permis d’atteindre des rendements compris entre 2,7% et 5,6% en moyenne. Ces dispositifs ont été ensuite intégrés en cellule tandem avec l’appui d’un outil de simulation optique permettant d’atteindre des rendements proches des 7% et affichant un gain de 1% en moyenne par rapport aux meilleures dispositifs simple jonction.L’étude de la stabilité a été ensuite faite suivant une approche systémique des propriétés optiques (UV-Visible), optoélectroniques (EQE et J(V)) et électroniques (Spectroscopie d’impédance et SKP) des dispositifs simple et double jonction et des matériaux seuls. Les diminutions de performances observées sont liées à une dégradation principalement causées par les molécules acceptrices utilisées. Une amélioration de la durée de vie des sous-cellules en architecture tandems a également été observée probablement due à un effet filtre.Enfin, une première étude de la spectroscopie d’impédance appliquée aux cellules tandems est présentée ; technique permettant potentiellement de suivre l’évolution de chaque sous-cellule indépendamment dans le temps.Mots-clés : cellule solaire photovoltaïque organique tandem, simulation optique, vieillissement, spectroscopie d’impédance, dimérisation, dégradation, PC71BM.

Organic photovoltaics is a promising technology with many advantages: flexibility, lightness, conformability, and low manufacturing costs. The only limiting factors to its commercialization are the moderate efficiency and the limited lifetime of the devices. One strategy that can increase its efficiency is the use of a tandem architecture which consists of a stack of two subcells with complementary absorption spectra. However, no study has been done on the stability of these devices. The objective of this thesis is to design high-performance tandem cells and study their stability under illumination AM1.5 1000 W/m². As a first step, the optimization of single cells allowed us to achieve efficiencies from 2.7% to 5.6% on average. These devices were then combined to form a tandem cell with the support of an optical simulation tool. This resulted in efficiency close to 7% and a gain of 1% on average compared to the best simple junction devices. A stability study was then carried out using a systemic…

Advisors/Committee Members: Perrier, Gérard (thesis director), Berson, Solenn (thesis director).

Subjects/Keywords: Photovoltaïque; Organique; Tandem; Polymère; Photovoltaic; Organic; Tandem; Polymer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schuchardt, G. (2017). Performance et durée de vie des architectures photovoltaïques organiques tandems : Performance and stability of tandem organic photovoltaic. (Doctoral Dissertation). Université Grenoble Alpes (ComUE). Retrieved from http://www.theses.fr/2017GREAA004

Chicago Manual of Style (16^th Edition):

Schuchardt, Guillaume. “Performance et durée de vie des architectures photovoltaïques organiques tandems : Performance and stability of tandem organic photovoltaic.” 2017. Doctoral Dissertation, Université Grenoble Alpes (ComUE). Accessed April 20, 2021. http://www.theses.fr/2017GREAA004.

MLA Handbook (7^th Edition):

Schuchardt, Guillaume. “Performance et durée de vie des architectures photovoltaïques organiques tandems : Performance and stability of tandem organic photovoltaic.” 2017. Web. 20 Apr 2021.

Vancouver:

Schuchardt G. Performance et durée de vie des architectures photovoltaïques organiques tandems : Performance and stability of tandem organic photovoltaic. [Internet] [Doctoral dissertation]. Université Grenoble Alpes (ComUE); 2017. [cited 2021 Apr 20]. Available from: http://www.theses.fr/2017GREAA004.

Council of Science Editors:

Schuchardt G. Performance et durée de vie des architectures photovoltaïques organiques tandems : Performance and stability of tandem organic photovoltaic. [Doctoral Dissertation]. Université Grenoble Alpes (ComUE); 2017. Available from: http://www.theses.fr/2017GREAA004

9. Richard, François D. Développement et application de méthodes bioinformatiques pour l'analyse des protéines contenant des répétitions en tandem : Development and application of bioinformatics methods for the identification and characterisation of tandem repeat in protein sequences.

Degree: Docteur es, Biologie Santé, 2016, Montpellier

URL: http://www.theses.fr/2016MONTT084

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De nos jours, l’augmentation du volume des données de séquençage est bien plus forte que celle de notre capacité à analyser ces données. En lien… (more)

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De nos jours, l’augmentation du volume des données de séquençage est bien plus forte que celle de notre capacité à analyser ces données. En lien avec ce déluge de données et le besoin urgent de nouveaux outils bioinformatiques pour les analyser, notre travail consiste à développer de nouveaux algorithmes pour mieux comprendre les relations entre séquence, structure, et fonction des protéines. Les protéines contiennent de larges portions de séquences périodiques, qui forment des motifs d’acides aminés répétés les uns à la suite des autres que l’on appelle des répétitions en tandem. Elles se retrouvent dans 14% des protéines. De nombreuses études ont montré leur importance fonctionnelle ainsi que leur implication dans de nombreuses maladies humaines, notamment le cancer. Ici, nous montrons l’importance d’adopter une approche incluant plusieurs outils de détection de répétition en tandem afin de s’assurer d’obtenir le jeu de données le plus complet. Nous avons ainsi réalisé un pipeline approprié, et développé deux outils spécifiques : un filtre, pour gagner en rapidité, et un score, pour sélectionner les répétitions les plus pertinentes dans les régions structurées des protéines. Enfin, nous avons utilisé ce pipeline sur une sélection de 94 protéomes. Cette analyse a permis de mettre à jour le précédent recensement des répétitions, montrant que 64% des protéines contenaient des répétitions en tandem. Elle a également permis de mieux comprendre les répétions en tandem dans leurs caractéristiques, leurs compositions et leurs implications dans les maladies humaines.

Today, the growth of protein sequencing data significantly exceeds the growth of capacities to analyze these data. In line with this data deluge and urgent needs in new bioinformatics tools our work deals with the development of new algorithms to better understand the sequence-structure-function relationship. Proteins contain a large portion of periodic sequences representing arrays of repeats that are directly adjacent to each other, so called tandem repeats (TRs). TRs occur at least in 14% of all proteins. Highly divergent, they range from a single amino acid repetition to domains of 100 or more repeated residues. Numerous studies demonstrated the fundamental functional importance of such TRs and their involvement in human diseases, especially cancers. Here we show the importance of integrating several TR detectors to get the most complete set of TRs in proteomes. We designed an appropriate pipeline and developed a filter to speed the process as well as a new scoring module to select relevant structured TRs. In addition, we undertook a large scale analysis of TRs in 94 proteomes. This large scale analysis allowed us to update previous census of TR showing that TRs occurs in 64% of all proteins and leads to a better understanding of TR in terms of their characteristics, composition and implication in human disease.

Advisors/Committee Members: Kajava, Andrey (thesis director).

Subjects/Keywords: Bioinformatique; Répétitions en tandem; Séquences; Protéomes; Bioinformatics; Tandem repeats; Sequences; Proteomes

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Richard, F. D. (2016). Développement et application de méthodes bioinformatiques pour l'analyse des protéines contenant des répétitions en tandem : Development and application of bioinformatics methods for the identification and characterisation of tandem repeat in protein sequences. (Doctoral Dissertation). Montpellier. Retrieved from http://www.theses.fr/2016MONTT084

Chicago Manual of Style (16^th Edition):

Richard, François D. “Développement et application de méthodes bioinformatiques pour l'analyse des protéines contenant des répétitions en tandem : Development and application of bioinformatics methods for the identification and characterisation of tandem repeat in protein sequences.” 2016. Doctoral Dissertation, Montpellier. Accessed April 20, 2021. http://www.theses.fr/2016MONTT084.

MLA Handbook (7^th Edition):

Richard, François D. “Développement et application de méthodes bioinformatiques pour l'analyse des protéines contenant des répétitions en tandem : Development and application of bioinformatics methods for the identification and characterisation of tandem repeat in protein sequences.” 2016. Web. 20 Apr 2021.

Vancouver:

Richard FD. Développement et application de méthodes bioinformatiques pour l'analyse des protéines contenant des répétitions en tandem : Development and application of bioinformatics methods for the identification and characterisation of tandem repeat in protein sequences. [Internet] [Doctoral dissertation]. Montpellier; 2016. [cited 2021 Apr 20]. Available from: http://www.theses.fr/2016MONTT084.

Council of Science Editors:

Richard FD. Développement et application de méthodes bioinformatiques pour l'analyse des protéines contenant des répétitions en tandem : Development and application of bioinformatics methods for the identification and characterisation of tandem repeat in protein sequences. [Doctoral Dissertation]. Montpellier; 2016. Available from: http://www.theses.fr/2016MONTT084

NSYSU

10. Lien, Kuan-Yi. The Study of Highly Efficient Single Emitting Layer White Light Organic Light-Emitting Diodes on Tandem Structure.

Degree: Master, Electro-Optical Engineering, 2009, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0727109-162851

► We report that the tandem OLEDs made of two electroluminescent (EL) units connected by the interconnecting layer. If It is compared wih the traditional OLEDs.… (more)

▼ We report that the tandem OLEDs made of two electroluminescent (EL) units connected by the interconnecting layer. If It is compared wih the traditional OLEDs. The tandem OLEDs have higher efficiency and well lifetime. We not only used the single emitting layer WOLEDs as EL unit but also studied the effect of the interconnecting layer for whole device. First, we designed the interconnecting layer with Alq3ï¼Li (1%) (n-doping layer)/MoO3 (p-doping layer), and we optimized the thickness of the interconnecting layer by using green unit cell (Alq3 for EML), ITO/NPB(65 nm)/Alq3(30 nm)/Alq3(30 nm)/Alq3(x nm)ï¼Li (1%)/MoO3(y nm)/NPB(65 nm)/Alq3(30 nm)/Alq3(30 nm)/LiF(0.8 nm)/Al(200 nm) x=10ï¼20ï¼30ï¼40ï¼y=1ï¼3ï¼5ï¼7ï¼10 We found that the best thickness of Alq3ï¼Li (1%) and MoO3 are 20 nm and 5 nm. In our study, we concluded that there are the best thickness to each interconnecting layer, and it keeps the charge balance between two units. Finally, we used our single emitting layer WOLEDs as unit cell, which used 1,3,5-Tri(1-pyrenyl)benzene (TPB3) as the host, and 4-(dicyanomethylene)-2-tert-butyl-6(1,1,7,7-tetramethyljulolidyl-9-enyl)-4H-pyran (DCJTB) as the guest, unit cell was ITO(130 nm)/NPB(65 nm)/ TPB3(30 nm)ï¼DCJTB(0.05%)/ Alq3(30 nm)/LiF(8 nm)/Al(200 nm) Whole device was ITO(130 nm)/NPB(65 nm)/ TPB3(30 nm)ï¼DCJTB(0.05%)/ Alq3(30 nm)/Alq3(20 nm)ï¼Li(1%)/MoO3(5 nm)/NPB(65 nm)/TPB3(30 nm)ï¼DCJTB(0.05%)/Alq3(30 nm)/ LiF(0.8 nm)/Al(200 nm) We got almost three times luminance from the tandem one at the same current density (670 cd/m2 for 2360 cd/m2 at 20 mA/cm2) and efficiency as high as 9.7 cd/A ( at 24 mA/cm2). Itâs a excellent contribution for device lifetime. But the operation voltage and the power efficiency didnât reach to our expectancy. In order to improve the disadvantage, we changed the concentration of n-doping layer Alq3ï¼Li (z %)ï¼z=1%ï¼2%ï¼3%. It was actually improved the turn-on voltage from 10 V to 7 V. But the luminescent characteristics also degenerated. Although we enhanced the charge mobility of the n-doping layer, it also caused the degeneration of luminescent characteristics because of the unbalance of the charge transference.We got the efficiency 8.1 cd/A ( at 14 V) and almost two times luminance from the tandem one at the same current density (670 cd/m2 for 1760 cd/m2 at 20 mA/cm2), most close to the white area of CIE coordinates was (0.30 , 0.37) at 15 V. Its range of CIE coordinates was (0.35 , 0.46)~(0.28 , 0.33) at 8 V~20 V. We have already developed the tandem WOLEDs using single white emitting layer as EL units that have never be reported. It not only maintained the advantages of the tandem structure, but also had excellent stability of luminescent characteristics at wide range operation voltage. We reached our goal to improve the WOLEDs and make it more suitable for commercial applications, especially for the development of light sources. Advisors/Committee Members: Mei-Ying Chang (committee member), Chih-Chien Lee (chair), Jui-Ming Yeh (chair), Yu-Kai Han (chair), Ping-Tsung Huang (chair).

Subjects/Keywords: white light; tandem; Organic Light-Emitting Diodes

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lien, K. (2009). The Study of Highly Efficient Single Emitting Layer White Light Organic Light-Emitting Diodes on Tandem Structure. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0727109-162851

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lien, Kuan-Yi. “The Study of Highly Efficient Single Emitting Layer White Light Organic Light-Emitting Diodes on Tandem Structure.” 2009. Thesis, NSYSU. Accessed April 20, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0727109-162851.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lien, Kuan-Yi. “The Study of Highly Efficient Single Emitting Layer White Light Organic Light-Emitting Diodes on Tandem Structure.” 2009. Web. 20 Apr 2021.

Vancouver:

Lien K. The Study of Highly Efficient Single Emitting Layer White Light Organic Light-Emitting Diodes on Tandem Structure. [Internet] [Thesis]. NSYSU; 2009. [cited 2021 Apr 20]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0727109-162851.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lien K. The Study of Highly Efficient Single Emitting Layer White Light Organic Light-Emitting Diodes on Tandem Structure. [Thesis]. NSYSU; 2009. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0727109-162851

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

11. Chen, Chien-Heng. The Study of Optoelectronic Characteristics in Single Connecting Layer White Organic Light-Emitting Diode with Tandem Structure and the Mechanism of Connecting Layer.

Degree: Master, Electro-Optical Engineering, 2012, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0813112-152809

► Tandem structure for OLED application with HAT-CN:Alq3 interlayer is studied. It has been found that tandem cell with such interlayer structure has a low turn-on… (more)

Subjects/Keywords: generation; mechanism; white light; tandem; OLED

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chen, C. (2012). The Study of Optoelectronic Characteristics in Single Connecting Layer White Organic Light-Emitting Diode with Tandem Structure and the Mechanism of Connecting Layer. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0813112-152809

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chen, Chien-Heng. “The Study of Optoelectronic Characteristics in Single Connecting Layer White Organic Light-Emitting Diode with Tandem Structure and the Mechanism of Connecting Layer.” 2012. Thesis, NSYSU. Accessed April 20, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0813112-152809.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chen, Chien-Heng. “The Study of Optoelectronic Characteristics in Single Connecting Layer White Organic Light-Emitting Diode with Tandem Structure and the Mechanism of Connecting Layer.” 2012. Web. 20 Apr 2021.

Vancouver:

Chen C. The Study of Optoelectronic Characteristics in Single Connecting Layer White Organic Light-Emitting Diode with Tandem Structure and the Mechanism of Connecting Layer. [Internet] [Thesis]. NSYSU; 2012. [cited 2021 Apr 20]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0813112-152809.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chen C. The Study of Optoelectronic Characteristics in Single Connecting Layer White Organic Light-Emitting Diode with Tandem Structure and the Mechanism of Connecting Layer. [Thesis]. NSYSU; 2012. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0813112-152809

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Ruhr Universität Bochum

12. Will, Joanna. Massenspektrometrische Ermittlung der Proteintargets von zytotoxischen Metallkomplexen in Blutserum und E. coli-Zellen.

Degree: 2008, Ruhr Universität Bochum

URL: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-23342

► Mittels kombinierter flüssigchromatographischer und ESI-MS/MS Methoden wurden die folgenden Verbindungen [(η6-p- Cymol)RuCl2(DMSO)], [Pt(dien)(H2O)](NO3)2, Hexacarbonyl[2-propyn-1-yl-acetylsalicylat]dicobalt (Co-ASS) und Cisplatin (cis- [(NH3)2PtCl2]) auf mögliche Bindungsstellen in den Proteinen… (more)

Subjects/Keywords: Tandem-Massenspektrometrie; Cisplatin; Serumproteine; Escherichia coli; Blutserum

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APA (6^th Edition):

Will, J. (2008). Massenspektrometrische Ermittlung der Proteintargets von zytotoxischen Metallkomplexen in Blutserum und E. coli-Zellen. (Thesis). Ruhr Universität Bochum. Retrieved from http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-23342

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Will, Joanna. “Massenspektrometrische Ermittlung der Proteintargets von zytotoxischen Metallkomplexen in Blutserum und E. coli-Zellen.” 2008. Thesis, Ruhr Universität Bochum. Accessed April 20, 2021. http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-23342.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Will, Joanna. “Massenspektrometrische Ermittlung der Proteintargets von zytotoxischen Metallkomplexen in Blutserum und E. coli-Zellen.” 2008. Web. 20 Apr 2021.

Vancouver:

Will J. Massenspektrometrische Ermittlung der Proteintargets von zytotoxischen Metallkomplexen in Blutserum und E. coli-Zellen. [Internet] [Thesis]. Ruhr Universität Bochum; 2008. [cited 2021 Apr 20]. Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-23342.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Will J. Massenspektrometrische Ermittlung der Proteintargets von zytotoxischen Metallkomplexen in Blutserum und E. coli-Zellen. [Thesis]. Ruhr Universität Bochum; 2008. Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-23342

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

UCLA

13. Fan, Yi Chiao. Tandem Phosphine–Palladium Catalysis and Total Syntheses of Natural Products.

Degree: Chemistry, 2015, UCLA

URL: http://www.escholarship.org/uc/item/5wf238tv

► In Chapter 1, tertiary phosphines undergo conjugate additions to activated carbon–carbon multiple bonds to form β-phosphonium enolates, β-phosphonium dienolates, β-phosphonium enoates, and vinyl phosphonium ylides… (more)

▼ In Chapter 1, tertiary phosphines undergo conjugate additions to activated carbon–carbon multiple bonds to form β-phosphonium enolates, β-phosphonium dienolates, β-phosphonium enoates, and vinyl phosphonium ylides as intermediates. When these reactive zwitterionic species react with nucleophiles and electrophiles, they may generate carbo- and heterocycles with multifarious molecular architectures. This article describes the reactivities of these phosphonium zwitterions, the applications of phosphine catalysis in the syntheses of biologically active compounds and natural products, and recent developments in the enantioselective phosphine catalysis.In Chapter 2, we prepared oxazolidines through 1,3-bis(diphenylphosphino)-propane (DPPP)–catalyzed mixed double-Michael reactions of β-amino alcohols with electron-deficient acetylenes. These reactions are very suitable for the diversity-oriented parallel syntheses of oxazolidines because: (i) they are performed under mild metal-free conditions and (ii) the products are isolated without complicated work-up. To demonstrate the applicability of mixed double-Michael reactions for the preparation of five-membered-ring heterocycles, we prepared 60 distinct oxazolidines from five β-amino alcohols and 12 electron-deficient acetylenes. We synthesized 36 of these 60 oxazolidines in enantiomerically pure form from proteinogenic amino acid–derived β-amino alcohols.In Chapter 3, we used sequential catalysis—PPh3-catalyzed nucleophilic addition followed by Pd(0)-catalyzed Heck cyclization—to construct complex functionalized alkylidene phthalans rapidly, in high yields, and with good stereoselectivities (E/Z ratios of up to 1:22). The scope of this Michael–Heck reaction includes substrates bearing various substituents around the alkylidene phthalan backbone. Applying this efficient sequential catalysis, we accomplished concise total syntheses of 3-deoxyisoochacinic acid, isoochracinic acid, and isoochracinol.In Chapter 4, densely functionalized alkylidene indanes and indanones can be prepared efficiently in one pot, in high yields with good stereoselectivities (in some cases exclusively the Z-isomer), through a route involving phosphine-catalyzed Michael addition followed by palladium-catalyzed Heck cyclization. These transformations tolerate substrates bearing various substituents around the indane/indanone motif. Employing this technology, a concise formal synthesis of sulindac, a non-steroidal anti-inflammatory drug, has been established.

Subjects/Keywords: Chemistry; Michael–Heck; Palladium; Phosphine; Tandem Catalysis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fan, Y. C. (2015). Tandem Phosphine–Palladium Catalysis and Total Syntheses of Natural Products. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/5wf238tv

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fan, Yi Chiao. “Tandem Phosphine–Palladium Catalysis and Total Syntheses of Natural Products.” 2015. Thesis, UCLA. Accessed April 20, 2021. http://www.escholarship.org/uc/item/5wf238tv.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fan, Yi Chiao. “Tandem Phosphine–Palladium Catalysis and Total Syntheses of Natural Products.” 2015. Web. 20 Apr 2021.

Vancouver:

Fan YC. Tandem Phosphine–Palladium Catalysis and Total Syntheses of Natural Products. [Internet] [Thesis]. UCLA; 2015. [cited 2021 Apr 20]. Available from: http://www.escholarship.org/uc/item/5wf238tv.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fan YC. Tandem Phosphine–Palladium Catalysis and Total Syntheses of Natural Products. [Thesis]. UCLA; 2015. Available from: http://www.escholarship.org/uc/item/5wf238tv

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

14. Cichowicz, Nathan R. Development of Tandem Chemical Processes for the Synthesis of Bioactive Natural Products.

Degree: PhD, Chemistry, 2015, University of Michigan

URL: http://hdl.handle.net/2027.42/113527

► The discovery of new reagents and the development of new tandem chemical processes, which permit access to bioactive natural products and therapeutic agents, is an… (more)

▼ The discovery of new reagents and the development of new tandem chemical processes, which permit access to bioactive natural products and therapeutic agents, is an area of great interest. Described herein is the development of two new tandem chemical processes: the synthesis of conjugated polyenes utilizing designed sulfonylphosphonate reagents and the stereoselective rapid assembly of steroid skeletons via a Michael-aldol-aldol cascade. Chapter 1 provides an overview of polyenes including their importance in medicine and materials science and synthetic advancements. Discussed is synthetic methods and strategies employed in polyene synthesis including the historically employed linear installation approach and recent advancements using iterative cross-coupling. Chapter 2 describes the development of sulfonylphosphonate reagents for the synthesis of unsymmetrical all trans-polyenes. Selective metalation of sulfonylphosphonate results in sufficiently stable carbanions that undergo chemoselective Julia-Kocienski condensation with aldehydes to provide (E)-allylic phosphonates in good yields and selectivities (16 examples, up to 85% yield, and up to >95:5 E:Z). The subsequent Horner-Wadsworth-Emmons condensation with aldehydes is used to synthesize various unsymmetrical trans-dienes, trienes, and tetraenes. This methodology was utilized in the concise synthesis (5 linear steps, 6 total steps) of a naturally occurring fluorescent probe, β-parinaric acid. Chapter 3 provides an overview of cardiotonic steroids including their structure, biologi-cal activity, and historical importance. The chapter focuses on synthetic strategies including semi-synthetic and synthetic methods and highlights the inherent challenges that prevent appre-ciable quantities of cardiotonic steroids to be synthesized. Chapter 4 describes a rapid conceptually new asymmetric approach to functionalized oxygenated steroid cores. Developed is the unprecedented chiral bis(oxazoline) copper(II) complex-catalyzed enantioselective and diastereoselective Michael reaction of cyclic ketoesters and enones to install challenging vicinal quaternary and tertiary stereocenters (8 examples, up to 95% yield, up to >20:1 dr, and up to 96% ee). These products subsequently undergo base-promoted diastereoselective aldol cascade reactions resulting in the natural (3 examples, up to 59% yield, up to >20:1 dr, and up to 92% ee) or unnatural (6 examples, up to 86% yield, >20:1 dr, and up to 99% ee) steroid skeletons. Advisors/Committee Members: Nagorny, Pavel (committee member), Soellner, Matthew Bryan (committee member), Wolfe, John P. (committee member), Matzger, Adam J. (committee member).

Subjects/Keywords: polyenes; steroids; tandem chemical processes; Chemistry; Science

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APA (6^th Edition):

Cichowicz, N. R. (2015). Development of Tandem Chemical Processes for the Synthesis of Bioactive Natural Products. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/113527

Chicago Manual of Style (16^th Edition):

Cichowicz, Nathan R. “Development of Tandem Chemical Processes for the Synthesis of Bioactive Natural Products.” 2015. Doctoral Dissertation, University of Michigan. Accessed April 20, 2021. http://hdl.handle.net/2027.42/113527.

MLA Handbook (7^th Edition):

Cichowicz, Nathan R. “Development of Tandem Chemical Processes for the Synthesis of Bioactive Natural Products.” 2015. Web. 20 Apr 2021.

Vancouver:

Cichowicz NR. Development of Tandem Chemical Processes for the Synthesis of Bioactive Natural Products. [Internet] [Doctoral dissertation]. University of Michigan; 2015. [cited 2021 Apr 20]. Available from: http://hdl.handle.net/2027.42/113527.

Council of Science Editors:

Cichowicz NR. Development of Tandem Chemical Processes for the Synthesis of Bioactive Natural Products. [Doctoral Dissertation]. University of Michigan; 2015. Available from: http://hdl.handle.net/2027.42/113527

University of Ghana

15. Berchie, E. Ion Beam Energy Calibration of the 1.7 MV Tandem Accelerator At GAEC .

Degree: 2018, University of Ghana

URL: http://ugspace.ug.edu.gh/handle/123456789/30400

► Particle accelerators are often used for both ion implantation and ion beam analysis, therefore the accurate and precise knowledge of the energies of the accelerated… (more)

Subjects/Keywords: Ion Beam; Energy; 1.7 MV Tandem; GAEC

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APA (6^th Edition):

Berchie, E. (2018). Ion Beam Energy Calibration of the 1.7 MV Tandem Accelerator At GAEC . (Masters Thesis). University of Ghana. Retrieved from http://ugspace.ug.edu.gh/handle/123456789/30400

Chicago Manual of Style (16^th Edition):

Berchie, E. “Ion Beam Energy Calibration of the 1.7 MV Tandem Accelerator At GAEC .” 2018. Masters Thesis, University of Ghana. Accessed April 20, 2021. http://ugspace.ug.edu.gh/handle/123456789/30400.

MLA Handbook (7^th Edition):

Berchie, E. “Ion Beam Energy Calibration of the 1.7 MV Tandem Accelerator At GAEC .” 2018. Web. 20 Apr 2021.

Vancouver:

Berchie E. Ion Beam Energy Calibration of the 1.7 MV Tandem Accelerator At GAEC . [Internet] [Masters thesis]. University of Ghana; 2018. [cited 2021 Apr 20]. Available from: http://ugspace.ug.edu.gh/handle/123456789/30400.

Council of Science Editors:

Berchie E. Ion Beam Energy Calibration of the 1.7 MV Tandem Accelerator At GAEC . [Masters Thesis]. University of Ghana; 2018. Available from: http://ugspace.ug.edu.gh/handle/123456789/30400

Oregon State University

16. Skinner, Amy M. Factors contributing to the formation of CC – >TT tandem mutations.

Degree: PhD, Toxicology, 2006, Oregon State University

URL: http://hdl.handle.net/1957/3636

► The multistage model of carcinogenesis states that an accumulation of mutations in genes that are important for maintaining cellular homeostasis may lead to cancer. A… (more)

Subjects/Keywords: tandem mutation; Mutagenesis

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APA (6^th Edition):

Skinner, A. M. (2006). Factors contributing to the formation of CC – >TT tandem mutations. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/3636

Chicago Manual of Style (16^th Edition):

Skinner, Amy M. “Factors contributing to the formation of CC – >TT tandem mutations.” 2006. Doctoral Dissertation, Oregon State University. Accessed April 20, 2021. http://hdl.handle.net/1957/3636.

MLA Handbook (7^th Edition):

Skinner, Amy M. “Factors contributing to the formation of CC – >TT tandem mutations.” 2006. Web. 20 Apr 2021.

Vancouver:

Skinner AM. Factors contributing to the formation of CC – >TT tandem mutations. [Internet] [Doctoral dissertation]. Oregon State University; 2006. [cited 2021 Apr 20]. Available from: http://hdl.handle.net/1957/3636.

Council of Science Editors:

Skinner AM. Factors contributing to the formation of CC – >TT tandem mutations. [Doctoral Dissertation]. Oregon State University; 2006. Available from: http://hdl.handle.net/1957/3636

17. Matos, Sara Mulenas Sá de. Identificação genética humana: estudos de novos marcadores genéticos do tipo STR e InDel.

Degree: 2013, Escola Superior de Saúde Egas Moniz

URL: https://www.rcaap.pt/detail.jsp?id=oai:comum.rcaap.pt:10400.26/5125

►

Dissertação para a obtenção do grau de Mestre em Biologia Molecular em Saúde

Os marcadores genéticos do tipo Short Tandem Repeats (STR), são os atualmente… (more)

▼

Dissertação para a obtenção do grau de Mestre em Biologia Molecular em Saúde

Os marcadores genéticos do tipo Short Tandem Repeats (STR), são os atualmente recomendados para a obtenção de perfis genéticos, sendo que, muito recentemente foi apresentado como obrigatório para uso forense, um novo conjunto destes marcadores. Não obstante, existem também outros tipos de marcadores genéticos passíveis de utilização para definir perfis genéticos, designadamente marcadores do tipo Inserção/Deleção, ou InDel. Os novos marcadores STR e a grande maioria dos marcadores InDel ainda não estão suficientemente estudados e implementados nos laboratórios forenses, pelo que é necessário validar a reação, calcular frequências alélicas, parâmetros estatísticos populacionais e forenses. Estudámos os novos marcadores STR e um conjunto de marcadores do tipo InDel numa amostra com cerca de 120 indivíduos do sul de Portugal, intervenientes em perícias médico-legais a decorrer no Instituto Nacional de Medicina Legal e Ciências Forenses. No que concerne aos marcadores STR incluídos no kit PowerPlex®ESI17 (promega), os ensaios de validação demonstraram a sua elevada sensibilidade, precisão e capacidade de detetar misturas de DNA. No entanto, relativamente aos limiares analíticos não está de acordo com o descrito anteriormente. Os parâmetros estatísticos populacionais e forenses estão de acordo com o esperado e o cálculo das distâncias genéticas demonstrou existir diferenças genéticas entre as populações em estudo. Relativamente aos marcadores do tipo InDel incluídos no kit Investigator DIPPlex® (Qiagen), os ensaios de validação demonstraram que o kit tem uma elevada sensibilidade, limiares analíticos relativamente baixos, boa capacidade de detetar misturas e boa precisão. As frequências alélicas estão em equilíbrio Hardy-Weinberg, no entanto os valores de heterozigotia não são os esperados. Os parâmetros estatísticos forenses estão de acordo com o esperado e o cálculo das 4 distâncias genéticas demonstrou que existem diferenças genéticas significativas relativamente a outras populações. Concluímos que ambos os kits poderão ser utilizados para a prática forense apesar de, aparentemente, não preencherem todos os requisitos habitualmente avançados para os marcadores genéticos a utilizar na rotina forense. Deverão ser realizados mais estudos com maior número de indivíduos e de diferentes populações.

Advisors/Committee Members: Amorim, António, Silva, Claúdia.

Subjects/Keywords: Marcadores genéticos; Short Tandem Repeats; InDel

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APA (6^th Edition):

Matos, S. M. S. d. (2013). Identificação genética humana: estudos de novos marcadores genéticos do tipo STR e InDel. (Thesis). Escola Superior de Saúde Egas Moniz. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:comum.rcaap.pt:10400.26/5125

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Matos, Sara Mulenas Sá de. “Identificação genética humana: estudos de novos marcadores genéticos do tipo STR e InDel.” 2013. Thesis, Escola Superior de Saúde Egas Moniz. Accessed April 20, 2021. https://www.rcaap.pt/detail.jsp?id=oai:comum.rcaap.pt:10400.26/5125.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Matos, Sara Mulenas Sá de. “Identificação genética humana: estudos de novos marcadores genéticos do tipo STR e InDel.” 2013. Web. 20 Apr 2021.

Vancouver:

Matos SMSd. Identificação genética humana: estudos de novos marcadores genéticos do tipo STR e InDel. [Internet] [Thesis]. Escola Superior de Saúde Egas Moniz; 2013. [cited 2021 Apr 20]. Available from: https://www.rcaap.pt/detail.jsp?id=oai:comum.rcaap.pt:10400.26/5125.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Matos SMSd. Identificação genética humana: estudos de novos marcadores genéticos do tipo STR e InDel. [Thesis]. Escola Superior de Saúde Egas Moniz; 2013. Available from: https://www.rcaap.pt/detail.jsp?id=oai:comum.rcaap.pt:10400.26/5125

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Australian National University

18. Wu, Yiliang. Towards Highly Efficient Perovskite/c-Si Monolithic Tandem Solar Cells .

Degree: 2018, Australian National University

URL: http://hdl.handle.net/1885/162745

► Solar photovoltaic technology based on crystalline silicon (c-Si) has dramatically reduced in cost in the last several years, to the point where the cost of… (more)

▼ Solar photovoltaic technology based on crystalline silicon (c-Si) has dramatically reduced in cost in the last several years, to the point where the cost of solar electricity now rivals that from coal power plants in many locations around the world. Increasing the power conversion efficiency is the most promising method to further reduce the cost. Since the efficiency of c-Si cells is approaching its theoretical limit, alternative approaches are required to enable step changes in efficiency. The rapid development of perovskite cells provides an opportunity to fabricate highly efficient perovskite/c-Si tandem cells, with an efficiency substantially greater than that possible with c-Si. One potential difficulty to achieve a highly efficient perovskite top cell for such a tandem device is the hysteresis behaviour usually displayed by these cells. It is necessary to understand the root causes of hysteresis in order to assess whether and to what extent the underlying mechanisms responsible will limit the efficiency or stability of the cells. We show for the first time, that the transient changes in terminal voltage and luminescent intensity do not follow the relationship that would be predicted by the generalised Planck radiation law. Using numerical simulation, we demonstrate that due to the accumulation of mobile ions at interfaces and together with significant defect related interface recombination, a resistive barrier to majority carrier flow at the interfaces between the perovskite film and the electron or hole transport layer can result in decoupling of the internal quasi-Fermi level separation and the externally measured voltage. Additional to the perovskite work, we report a specially designed homojunction c-Si solar cell architecture which provides a wide window for the perovskite top cell processing temperature of up to 400 °C, and which features passivation on both sides of the c-Si substrate using conventional, industry standard homojunction (diffused junction) technology. With a modified vacuum flash assisted perovskite deposition method, we demonstrate a 1 cm2 monolithic perovskite/c-Si tandem cell with 22.5% stabilized efficiency, which is the highest efficiency reported to date with a homojunction c-Si substrate. The unique design presented in this work opens up a new approach for achieving highly efficient monolithic perovskite/c-Si tandem devices. In the final work, we carefully investigate the monolithic tandems based on HJT (heterojunction technology) and PERT (passivated emitter rear totally diffused) structures recently published. Based on the simulation results, for both structures, we show that a significant increase in efficiency can be achieved by simply reducing the resistivity of the c-Si wafer and changing the wafer from n-type to p-type without changing…

Subjects/Keywords: perovskite; silicon; tandem; hysteresis; solar cell

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APA (6^th Edition):

Wu, Y. (2018). Towards Highly Efficient Perovskite/c-Si Monolithic Tandem Solar Cells . (Thesis). Australian National University. Retrieved from http://hdl.handle.net/1885/162745

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wu, Yiliang. “Towards Highly Efficient Perovskite/c-Si Monolithic Tandem Solar Cells .” 2018. Thesis, Australian National University. Accessed April 20, 2021. http://hdl.handle.net/1885/162745.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wu, Yiliang. “Towards Highly Efficient Perovskite/c-Si Monolithic Tandem Solar Cells .” 2018. Web. 20 Apr 2021.

Vancouver:

Wu Y. Towards Highly Efficient Perovskite/c-Si Monolithic Tandem Solar Cells . [Internet] [Thesis]. Australian National University; 2018. [cited 2021 Apr 20]. Available from: http://hdl.handle.net/1885/162745.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wu Y. Towards Highly Efficient Perovskite/c-Si Monolithic Tandem Solar Cells . [Thesis]. Australian National University; 2018. Available from: http://hdl.handle.net/1885/162745

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Kwame Nkrumah University of Science and Technology

19. Opoku, Ernest; Tia, Richard. Quantum chemical studies on the mechanistic aspects of tandemsequential cycloaddition reactions of cyclooctatetraene with ester andnitrones.

Degree: 2019, Kwame Nkrumah University of Science and Technology

URL: E. Opoku et al. / Journal of Molecular Graphics and Modelling 92 (2019) 17e31. https://doi.org/10.1016/j.jmgm.2019.06.019 ; http://dspace.knust.edu.gh:8080/jspui/handle/123456789/12653

►

The mechanisms of the tandem sequential [4þ2]/[3þ2] and [3þ2]/[4þ2] cycloaddition sequencesinvolving an ester, cyclooctatetraene (COTE), and cyclic and acyclic nitrones for the formation of a… (more)

Subjects/Keywords: Isoxazolidines; Mechanistic stud; Tandem addition; Cyclooctatetraene; Nitrones

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APA (6^th Edition):

Opoku, Ernest; Tia, R. (2019). Quantum chemical studies on the mechanistic aspects of tandemsequential cycloaddition reactions of cyclooctatetraene with ester andnitrones. (Thesis). Kwame Nkrumah University of Science and Technology. Retrieved from E. Opoku et al. / Journal of Molecular Graphics and Modelling 92 (2019) 17e31. https://doi.org/10.1016/j.jmgm.2019.06.019 ; http://dspace.knust.edu.gh:8080/jspui/handle/123456789/12653

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Opoku, Ernest; Tia, Richard. “Quantum chemical studies on the mechanistic aspects of tandemsequential cycloaddition reactions of cyclooctatetraene with ester andnitrones.” 2019. Thesis, Kwame Nkrumah University of Science and Technology. Accessed April 20, 2021. E. Opoku et al. / Journal of Molecular Graphics and Modelling 92 (2019) 17e31. https://doi.org/10.1016/j.jmgm.2019.06.019 ; http://dspace.knust.edu.gh:8080/jspui/handle/123456789/12653.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Opoku, Ernest; Tia, Richard. “Quantum chemical studies on the mechanistic aspects of tandemsequential cycloaddition reactions of cyclooctatetraene with ester andnitrones.” 2019. Web. 20 Apr 2021.

Vancouver:

Opoku, Ernest; Tia R. Quantum chemical studies on the mechanistic aspects of tandemsequential cycloaddition reactions of cyclooctatetraene with ester andnitrones. [Internet] [Thesis]. Kwame Nkrumah University of Science and Technology; 2019. [cited 2021 Apr 20]. Available from: E. Opoku et al. / Journal of Molecular Graphics and Modelling 92 (2019) 17e31. https://doi.org/10.1016/j.jmgm.2019.06.019 ; http://dspace.knust.edu.gh:8080/jspui/handle/123456789/12653.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Opoku, Ernest; Tia R. Quantum chemical studies on the mechanistic aspects of tandemsequential cycloaddition reactions of cyclooctatetraene with ester andnitrones. [Thesis]. Kwame Nkrumah University of Science and Technology; 2019. Available from: E. Opoku et al. / Journal of Molecular Graphics and Modelling 92 (2019) 17e31. https://doi.org/10.1016/j.jmgm.2019.06.019 ; http://dspace.knust.edu.gh:8080/jspui/handle/123456789/12653

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Delft University of Technology

20. Wang, Zidan (author). Improvements and Experimental Validation of the PVMD Toolbox: An Energy Yield Prediction Model for PV Systems.

Degree: 2019, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:5cc83e7e-e18e-4c80-9ab0-91616af83978

► Photovoltaic (PV) system yield prediction models are an important topic in the field of PV solar energy. An accurate prediction model could not only be… (more)

▼ Photovoltaic (PV) system yield prediction models are an important topic in the field of PV solar energy. An accurate prediction model could not only be used for optimising the PV system design, but is also expected to realise the yield potential of innovative PV technologies. In the next generation of PV technologies, one of the most promising concepts is the tandem solar cells. In recent years, these cells have impressed the solar industry by their rapid growth of the maximum power conversion efficiency (PCE). Since tandem solar cells are still at the lab phase, their yield potential under realistic conditions are an interesting field of study as well. However, the existing yield prediction models are not yet available for these tandem cells. In order to fill this gap, a prediction model developed in the Photovoltaic Materials and Devices (PVMD) group of TU Delft, called the PVMD Toolbox, has been adapted to be compatible with the tandem solar cells. In this thesis project, the version 3 of the Toolbox was developed. First the PVMD Toolbox was improved. Except monofacial c-Si cells and bifacial c-Si cell, it is now also available for tandem cells. One of the most promising tandem concepts, the perovskite/c-Si tandem, was taken as a reference tandem configuration integrated in the Toolbox. The Toolbox was also modified to take the influence of solar spectra into consideration and analyses cell performances individually. Secondly, the accuracy of the Toolbox was validated. A new figure of merit called 'relative total deviation' is put forward in this report, which calculates the ratio between the sum of deviations that each simulation introduces, and the total measured energy yield. When the electrical parameters were taken from the own measurements, the relative total deviation of simulation results was only 8.6%. Finally, the Toolbox was applied to two case studies. In the first study, it was found that the annual energy yield (AEY) of perovskite tandems can be increased up to 0.4% by optimising perovskite thickness for a certain location. The second case study compared the AEY of the tandem module and conventional c-Si module. Perovskite tandem module showed a high AEY, around 36% higher than that of the c-Si module. However, perovskite tandem had a lower specific yield as they are more sensitive to the spectral variation Advisors/Committee Members: Isabella, Olindo (mentor), Santbergen, Rudi (mentor), van Swaaij, Rene (graduation committee), Qin, Zian (graduation committee), Delft University of Technology (degree granting institution).

Subjects/Keywords: PV systems; Tandem solar cells; System modelling

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wang, Z. (. (2019). Improvements and Experimental Validation of the PVMD Toolbox: An Energy Yield Prediction Model for PV Systems. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:5cc83e7e-e18e-4c80-9ab0-91616af83978

Chicago Manual of Style (16^th Edition):

Wang, Zidan (author). “Improvements and Experimental Validation of the PVMD Toolbox: An Energy Yield Prediction Model for PV Systems.” 2019. Masters Thesis, Delft University of Technology. Accessed April 20, 2021. http://resolver.tudelft.nl/uuid:5cc83e7e-e18e-4c80-9ab0-91616af83978.

MLA Handbook (7^th Edition):

Wang, Zidan (author). “Improvements and Experimental Validation of the PVMD Toolbox: An Energy Yield Prediction Model for PV Systems.” 2019. Web. 20 Apr 2021.

Vancouver:

Wang Z(. Improvements and Experimental Validation of the PVMD Toolbox: An Energy Yield Prediction Model for PV Systems. [Internet] [Masters thesis]. Delft University of Technology; 2019. [cited 2021 Apr 20]. Available from: http://resolver.tudelft.nl/uuid:5cc83e7e-e18e-4c80-9ab0-91616af83978.

Council of Science Editors:

Wang Z(. Improvements and Experimental Validation of the PVMD Toolbox: An Energy Yield Prediction Model for PV Systems. [Masters Thesis]. Delft University of Technology; 2019. Available from: http://resolver.tudelft.nl/uuid:5cc83e7e-e18e-4c80-9ab0-91616af83978

University of Ottawa

21. Beach, Nicholas James. Metathesis Catalysts in Tandem Catalysis: Methods and Mechanisms for Transformation .

Degree: 2012, University of Ottawa

URL: http://hdl.handle.net/10393/22731

► The ever-worsening environmental crisis has stimulated development of less wasteful “green” technologies. To this end, tandem catalysis enables multiple catalytic cycles to be performed within… (more)

Subjects/Keywords: metathesis; hydridocarbonyl; ruthenium; tandem catalysis; hydrogenation

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APA (6^th Edition):

Beach, N. J. (2012). Metathesis Catalysts in Tandem Catalysis: Methods and Mechanisms for Transformation . (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/22731

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Beach, Nicholas James. “Metathesis Catalysts in Tandem Catalysis: Methods and Mechanisms for Transformation .” 2012. Thesis, University of Ottawa. Accessed April 20, 2021. http://hdl.handle.net/10393/22731.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Beach, Nicholas James. “Metathesis Catalysts in Tandem Catalysis: Methods and Mechanisms for Transformation .” 2012. Web. 20 Apr 2021.

Vancouver:

Beach NJ. Metathesis Catalysts in Tandem Catalysis: Methods and Mechanisms for Transformation . [Internet] [Thesis]. University of Ottawa; 2012. [cited 2021 Apr 20]. Available from: http://hdl.handle.net/10393/22731.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Beach NJ. Metathesis Catalysts in Tandem Catalysis: Methods and Mechanisms for Transformation . [Thesis]. University of Ottawa; 2012. Available from: http://hdl.handle.net/10393/22731

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Miami

22. Schuchardt, Brett. Biophysical Basis of the Antagonistic Action of YAP Transcriptional Regulator and WWOX Tumor Suppressor.

Degree: MS, Biochemistry and Molecular Biology (Medicine), 2015, University of Miami

URL: https://scholarlyrepository.miami.edu/oa_theses/543

► WW-domain containing proteins such as the antagonistic pair, YAP2 transcriptional regulator and WWOX tumor suppressor, mediate a multitude of homeostatic cellular processes including cell… (more)

▼ WW-domain containing proteins such as the antagonistic pair, YAP2 transcriptional regulator and WWOX tumor suppressor, mediate a multitude of homeostatic cellular processes including cell growth, proliferation, and apoptosis through specific interactions with shared PPXY-containing cognate ligands, which help transmit signals from the plasma membrane through the cytosol into the nucleus. Although there are numerous cell and mouse studies describing the signaling cascade events of such protein-protein interactions, the molecular basis of WW-PPXY interactions has yet to be explored. In addition, the ability of WW domains to act alone or in tandem, such as those found in YAP2 and WWOX, may uncover additional mechanisms of communication between WW domains. Therefore, we provide here a detailed biophysical analysis of the binding of WW domains of YAP2 and WWOX, acting alone and in the context of tandem domains, to shared PPXY-containing cognate ligands to uncover the molecular basis for the antagonistic action of these two proteins. Our data show that while both the WW1 and WW2 domains of YAP2 bind PPXY motifs of the ErbB4 receptor tyrosine kinase in a physiologically relevant matter, only the WW1 domain of WWOX is able to bind ErbB4. While replacement of consensus residues in the PPXY sequence eliminates binding of WW domains to ErbB4, non-consensus residues are not essential for WW-PPXY binding integrity. The lack of binding of the WW2 domain of WWOX to PPXY motifs is due to the replacement of a signature tryptophan, lining the hydrophobic ligand binding groove, with tyrosine (Y85). Of particular significance is the observation that the WW2 domain augments the binding of the WW1 domain to ErbB4, implying that the former serves as a chaperone within the context of the WW1-WW2 tandem module of WWOX. Interdomain communication between tandem WW domains of YAP2 and WWOX was explored using a myriad of shared cognate ligands. Our data suggest that the WW tandem domains of YAP2 negatively cooperate when binding to their cognate ligands due to unfavorable entropic contribution to the overall free energy of binding relative to isolated WW domains. YAP2 WW tandem domains also adopt a fixed spatial orientation such that the WW1 domain curves outward and stacks onto the binding groove of WW2 domain, thereby sterically hindering ligand binding to both domains. In contrast, tandem WW domains of WWOX demonstrate binding with enhanced affinity via allosteric communication such that the physical association of WW2 domain with WW1 blocks access to ligand. Consequently, ligand binding to WWOX WW1 domain not only results in the displacement of WW2 lid but also disrupts the WW domain interaction in the liganded conformation. Overall, these studies explore WW-PPXY interactions and uncover novel modes of communication between the tandem WW domains of YAP2 transcriptional regulator and WWOX tumor suppressor to describe the biophysical basis of their cellular antagonism. Advisors/Committee Members: Sapna Deo, Zafar Nawaz, Arun Malhotra, Michal Toborek.

Subjects/Keywords: YAP2; WWOX; biophysics; WW domain; tandem; thermodynamics

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APA (6^th Edition):

Schuchardt, B. (2015). Biophysical Basis of the Antagonistic Action of YAP Transcriptional Regulator and WWOX Tumor Suppressor. (Thesis). University of Miami. Retrieved from https://scholarlyrepository.miami.edu/oa_theses/543

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Schuchardt, Brett. “Biophysical Basis of the Antagonistic Action of YAP Transcriptional Regulator and WWOX Tumor Suppressor.” 2015. Thesis, University of Miami. Accessed April 20, 2021. https://scholarlyrepository.miami.edu/oa_theses/543.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Schuchardt, Brett. “Biophysical Basis of the Antagonistic Action of YAP Transcriptional Regulator and WWOX Tumor Suppressor.” 2015. Web. 20 Apr 2021.

Vancouver:

Schuchardt B. Biophysical Basis of the Antagonistic Action of YAP Transcriptional Regulator and WWOX Tumor Suppressor. [Internet] [Thesis]. University of Miami; 2015. [cited 2021 Apr 20]. Available from: https://scholarlyrepository.miami.edu/oa_theses/543.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Schuchardt B. Biophysical Basis of the Antagonistic Action of YAP Transcriptional Regulator and WWOX Tumor Suppressor. [Thesis]. University of Miami; 2015. Available from: https://scholarlyrepository.miami.edu/oa_theses/543

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen

23. Antal, Borbála. Poliéterek és a diizodecil-ftalát fragmentáció aktiválási energiájának becslése tandem tömegspektrometria segítségével .

Degree: DE – TEK – Természettudományi és Technológiai Kar – Kémiai Intézet, 2013, University of Debrecen

URL: http://hdl.handle.net/2437/168315

Tanden tömegspektrometriás módszerrel, SY görbe segítségével poliéterek és a diizodecil-ftalát karakterisztikus ütközési energiáját határoztam meg. Leucin enkefalin értékei alapján RRKM és RRK modelleket alkalmazva a vizsgált vegyületek fragmentáció aktiválási energiáját becsültem. Advisors/Committee Members: Nagy, Lajos (advisor).

Subjects/Keywords: tandem tömegspektrometria; fragmentáció; poliéter; aktiválási energia

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APA (6^th Edition):

Antal, B. (2013). Poliéterek és a diizodecil-ftalát fragmentáció aktiválási energiájának becslése tandem tömegspektrometria segítségével . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/168315

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Antal, Borbála. “Poliéterek és a diizodecil-ftalát fragmentáció aktiválási energiájának becslése tandem tömegspektrometria segítségével .” 2013. Thesis, University of Debrecen. Accessed April 20, 2021. http://hdl.handle.net/2437/168315.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Antal, Borbála. “Poliéterek és a diizodecil-ftalát fragmentáció aktiválási energiájának becslése tandem tömegspektrometria segítségével .” 2013. Web. 20 Apr 2021.

Vancouver:

Antal B. Poliéterek és a diizodecil-ftalát fragmentáció aktiválási energiájának becslése tandem tömegspektrometria segítségével . [Internet] [Thesis]. University of Debrecen; 2013. [cited 2021 Apr 20]. Available from: http://hdl.handle.net/2437/168315.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Antal B. Poliéterek és a diizodecil-ftalát fragmentáció aktiválási energiájának becslése tandem tömegspektrometria segítségével . [Thesis]. University of Debrecen; 2013. Available from: http://hdl.handle.net/2437/168315

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen

24. Fekete, Zoltán. Sztereoizomerek tanulmányozása tandem tömegspektrometriás módszerrel .

Degree: DE – Természettudományi és Technológiai Kar – Kémiai Intézet, University of Debrecen

URL: http://hdl.handle.net/2437/240360

Az ESI körülmények közt képződő különböző konfigurációjú α-aminosavak dimer ionjainak a tandem tömegspektrometriás vizsgálata királis megkülönböztetés céljából. A megkülönböztetéshez a diasztereomer dimer addukt ionok fragmentációjának az energiafüggése ad lehetőséget. Diasztereomer addukt ionok királis segédreagenssel képezhetőek. Advisors/Committee Members: Nagy, Tibor (advisor).

Subjects/Keywords: Tömegspektrometria; tandem; aminosavak

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APA (6^th Edition):

Fekete, Z. (n.d.). Sztereoizomerek tanulmányozása tandem tömegspektrometriás módszerrel . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/240360

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fekete, Zoltán. “Sztereoizomerek tanulmányozása tandem tömegspektrometriás módszerrel .” Thesis, University of Debrecen. Accessed April 20, 2021. http://hdl.handle.net/2437/240360.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fekete, Zoltán. “Sztereoizomerek tanulmányozása tandem tömegspektrometriás módszerrel .” Web. 20 Apr 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Fekete Z. Sztereoizomerek tanulmányozása tandem tömegspektrometriás módszerrel . [Internet] [Thesis]. University of Debrecen; [cited 2021 Apr 20]. Available from: http://hdl.handle.net/2437/240360.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Fekete Z. Sztereoizomerek tanulmányozása tandem tömegspektrometriás módszerrel . [Thesis]. University of Debrecen; Available from: http://hdl.handle.net/2437/240360

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Boston College

25. Xiao, Lu. Copper-Catalyzed Borylation of Hemiaminal Ethers and Ruthenium-Catalyzed Tandem Reactions of Nitrogen-Tethered Dienes.

Degree: PhD, Chemistry, 2016, Boston College

URL: http://dlib.bc.edu/islandora/object/bc-ir:107234

► Chapter 1 Bisphosphine monoxides have unique coordinating capabilities with transition metals. Several research groups have independently reported transition metal-catalyzed highly stereoselective reactions by using chiral… (more)

Subjects/Keywords: Borylation; Catalysis; Copper; Ruthenium; Tandem Reactions

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Xiao, L. (2016). Copper-Catalyzed Borylation of Hemiaminal Ethers and Ruthenium-Catalyzed Tandem Reactions of Nitrogen-Tethered Dienes. (Doctoral Dissertation). Boston College. Retrieved from http://dlib.bc.edu/islandora/object/bc-ir:107234

Chicago Manual of Style (16^th Edition):

Xiao, Lu. “Copper-Catalyzed Borylation of Hemiaminal Ethers and Ruthenium-Catalyzed Tandem Reactions of Nitrogen-Tethered Dienes.” 2016. Doctoral Dissertation, Boston College. Accessed April 20, 2021. http://dlib.bc.edu/islandora/object/bc-ir:107234.

MLA Handbook (7^th Edition):

Xiao, Lu. “Copper-Catalyzed Borylation of Hemiaminal Ethers and Ruthenium-Catalyzed Tandem Reactions of Nitrogen-Tethered Dienes.” 2016. Web. 20 Apr 2021.

Vancouver:

Xiao L. Copper-Catalyzed Borylation of Hemiaminal Ethers and Ruthenium-Catalyzed Tandem Reactions of Nitrogen-Tethered Dienes. [Internet] [Doctoral dissertation]. Boston College; 2016. [cited 2021 Apr 20]. Available from: http://dlib.bc.edu/islandora/object/bc-ir:107234.

Council of Science Editors:

Xiao L. Copper-Catalyzed Borylation of Hemiaminal Ethers and Ruthenium-Catalyzed Tandem Reactions of Nitrogen-Tethered Dienes. [Doctoral Dissertation]. Boston College; 2016. Available from: http://dlib.bc.edu/islandora/object/bc-ir:107234

Boston College

26. Gavenonis, Jason. Tandem Reactions of Dienes Generated by Enyne Metathesis.

Degree: PhD, Chemistry, 2010, Boston College

URL: http://dlib.bc.edu/islandora/object/bc-ir:101707

► A catalyst of notoriety Decomposes with great variety. Transformations after metathesis Facilitate tandem catalysis. This reaction has a proclivity For new regioselectivity With methanolic modification:… (more)

Subjects/Keywords: Hydroarylation; Hydrovinylation; Metathesis; Ruthenium; Tandem Catalysis

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APA (6^th Edition):

Gavenonis, J. (2010). Tandem Reactions of Dienes Generated by Enyne Metathesis. (Doctoral Dissertation). Boston College. Retrieved from http://dlib.bc.edu/islandora/object/bc-ir:101707

Chicago Manual of Style (16^th Edition):

Gavenonis, Jason. “Tandem Reactions of Dienes Generated by Enyne Metathesis.” 2010. Doctoral Dissertation, Boston College. Accessed April 20, 2021. http://dlib.bc.edu/islandora/object/bc-ir:101707.

MLA Handbook (7^th Edition):

Gavenonis, Jason. “Tandem Reactions of Dienes Generated by Enyne Metathesis.” 2010. Web. 20 Apr 2021.

Vancouver:

Gavenonis J. Tandem Reactions of Dienes Generated by Enyne Metathesis. [Internet] [Doctoral dissertation]. Boston College; 2010. [cited 2021 Apr 20]. Available from: http://dlib.bc.edu/islandora/object/bc-ir:101707.

Council of Science Editors:

Gavenonis J. Tandem Reactions of Dienes Generated by Enyne Metathesis. [Doctoral Dissertation]. Boston College; 2010. Available from: http://dlib.bc.edu/islandora/object/bc-ir:101707

Boston University

27. Huang, Rui Fen. STR amplification of DNA mixtures: fidelity of contributor proportion when calculated from DNA profile data using known mixture samples.

Degree: MS, Biomedical Forensic Sciences, 2013, Boston University

URL: http://hdl.handle.net/2144/17132

► DNA mixtures are frequently encountered in forensic casework especially in cases of sexual assault. When evidence is recovered, the sample may have come from multiple… (more)

Subjects/Keywords: Short tandem repeats (STR); Forensic casework; DNA

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APA (6^th Edition):

Huang, R. F. (2013). STR amplification of DNA mixtures: fidelity of contributor proportion when calculated from DNA profile data using known mixture samples. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/17132

Chicago Manual of Style (16^th Edition):

Huang, Rui Fen. “STR amplification of DNA mixtures: fidelity of contributor proportion when calculated from DNA profile data using known mixture samples.” 2013. Masters Thesis, Boston University. Accessed April 20, 2021. http://hdl.handle.net/2144/17132.

MLA Handbook (7^th Edition):

Huang, Rui Fen. “STR amplification of DNA mixtures: fidelity of contributor proportion when calculated from DNA profile data using known mixture samples.” 2013. Web. 20 Apr 2021.

Vancouver:

Huang RF. STR amplification of DNA mixtures: fidelity of contributor proportion when calculated from DNA profile data using known mixture samples. [Internet] [Masters thesis]. Boston University; 2013. [cited 2021 Apr 20]. Available from: http://hdl.handle.net/2144/17132.

Council of Science Editors:

Huang RF. STR amplification of DNA mixtures: fidelity of contributor proportion when calculated from DNA profile data using known mixture samples. [Masters Thesis]. Boston University; 2013. Available from: http://hdl.handle.net/2144/17132

Boston University

28. Hogan, John. Methods in automated glycosaminoglycan tandem mass spectra analysis.

Degree: PhD, Bioinformatics GRS, 2019, Boston University

URL: http://hdl.handle.net/2144/34811

► Glycosylation is the process by which a glycan is enzymatically attached to a protein, and is one of the most common post-translational modifications in nature.… (more)

▼ Glycosylation is the process by which a glycan is enzymatically attached to a protein, and is one of the most common post-translational modifications in nature. One class of glycans is the glycosaminoglycans (GAGs), which are long, linear polysaccharides that are variably sulfated and make up the glycan portion of proteoglycans (PGs). PGs are located on the cellular surface and in the extracellular matrix (ECM), making them important molecules for cell signaling and ligand binding. The GAG sulfation sequence is a determining factor for the signaling capacity of binding complexes, so accurate determination of the sequence is critical. Historically, GAG sequencing using tandem mass spectrometry (MS2) has been a difficult, manual process; however, with the advent of faster computational techniques and higher-resolution MS2, high-throughput GAG sequencing is within reach. Two steps in the pipeline of biomolecule sequencing using MS2 are discovery and interpretation of spectral peaks. The discovery step traditionally is performed using methods that rely on the concept of averagine, or the average molecular building block for the analyte in question. These methods were developed for protein sequencing, but perform considerably worse on GAG sequences, due to the non-uniform distribution of sulfur atoms along the chain and the relatively high isotope abundance of 34S. The interpretation step traditionally is performed manually, which takes time and introduces potential user error. To combat these problems, I developed GAGfinder, the first GAG-specific MS2 peak finding and annotation software. GAGfinder is described in detail in chapter two. Another step in MS2 sequencing is the determination of the sequence using the found MS2 fragments. For a given GAG composition, there are many possible sequences, and peak finding algorithms such as GAGfinder return a list of the peaks in the MS2 mass spectrum. The many-to-many relationship between sequences and fragments can be represented using a bipartite network, and node-ranking techniques can be employed to generate likelihood scores for possible sequences. I developed a bipartite network-based sequencing tool, GAGrank, based on a bipartite network extension of Google’s PageRank algorithm for ranking websites. GAGrank is described in detail in chapter three. Advisors/Committee Members: Zaia, Joseph (advisor).

Subjects/Keywords: Bioinformatics; Glycosaminoglycan; Networks; Sequencing; Tandem mass spectrometry

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APA (6^th Edition):

Hogan, J. (2019). Methods in automated glycosaminoglycan tandem mass spectra analysis. (Doctoral Dissertation). Boston University. Retrieved from http://hdl.handle.net/2144/34811

Chicago Manual of Style (16^th Edition):

Hogan, John. “Methods in automated glycosaminoglycan tandem mass spectra analysis.” 2019. Doctoral Dissertation, Boston University. Accessed April 20, 2021. http://hdl.handle.net/2144/34811.

MLA Handbook (7^th Edition):

Hogan, John. “Methods in automated glycosaminoglycan tandem mass spectra analysis.” 2019. Web. 20 Apr 2021.

Vancouver:

Hogan J. Methods in automated glycosaminoglycan tandem mass spectra analysis. [Internet] [Doctoral dissertation]. Boston University; 2019. [cited 2021 Apr 20]. Available from: http://hdl.handle.net/2144/34811.

Council of Science Editors:

Hogan J. Methods in automated glycosaminoglycan tandem mass spectra analysis. [Doctoral Dissertation]. Boston University; 2019. Available from: http://hdl.handle.net/2144/34811

University of Manchester

29. Abdul Hamid, Mohd Faisal. Aerodynamic models for insect flight.

Degree: PhD, 2016, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/aerodynamic-models-for-insect-flight(057be27b-265a-45a0-b8d0-dc3c02a62a77).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.728093

► Numerical models of insect flapping flight have previously been developed and used to simulate the performance of insect flight. These models were commonly developed via… (more)

▼ Numerical models of insect flapping flight have previously been developed and used to simulate the performance of insect flight. These models were commonly developed via Blade Element Theory, offering efficient computation, thus allowing them to be coupled with optimisation procedures for predicting optimal flight. However, the models have only been used for simulating hover flight, and often neglect the presence of the induced flow effect. Although some models account for the induced flow effect, the rapid changes of this effect on each local wing element have not been modelled. Crucially, this effect appears in both axial and radial directions, which influences the direction and magnitude of the incoming air, and hence the resulting aerodynamic forces. This thesis describes the development of flapping wing models aimed at advancing theoretical tools for simulating the optimum performance of insect flight. Two models are presented: single and tandem wing configurations for hawk moth and dragonfly, respectively. These models are designed by integrating a numerical design procedure to account for the induced flow effects. This approach facilitates the determination of the instantaneous relative velocity at any given spanwise location on the wing, following the changes of the axial and radial induced flow effects on the wing. For the dragonfly, both wings are coupled to account for the interaction of the flow, particularly the fact that the hindwing operates in the slipstream of the forewing. A heuristic optimisation procedure (particle swarming) is used to optimise the stroke or the wing kinematics at all flight conditions (hover, level, and accelerating flight). The cost function is the propulsive efficiency coupled with constraints for flight stability. The vector of the kinematic variables consists of up to 28 independent parameters (14 per wing for a dragonfly), each with a constrained range derived from the maximum available power, the flight muscle ratio, and the kinematics of real insects; this will prevent physically-unrealistic solutions of the wing motion. The model developed in this thesis accounts for the induced flow, and eliminates the dependency on the empirical translation lift coefficient. Validations are shown with numerical simulations for the hover case, and with experimental results for the forward flight case. From the results obtained, the effect of the induced velocity is found to be greatest in the middle of the stroke. The use of an optimisation process is shown to greatly improve the flapping kinematics, resulting in low power consumption in all flight conditions. In addition, a study on dragonfly flight has shown that the maximum acceleration is dependent on the size of the flight muscle.

Subjects/Keywords: 629.13; flapping wing; insect flight; tandem wing

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APA (6^th Edition):

Abdul Hamid, M. F. (2016). Aerodynamic models for insect flight. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/aerodynamic-models-for-insect-flight(057be27b-265a-45a0-b8d0-dc3c02a62a77).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.728093

Chicago Manual of Style (16^th Edition):

Abdul Hamid, Mohd Faisal. “Aerodynamic models for insect flight.” 2016. Doctoral Dissertation, University of Manchester. Accessed April 20, 2021. https://www.research.manchester.ac.uk/portal/en/theses/aerodynamic-models-for-insect-flight(057be27b-265a-45a0-b8d0-dc3c02a62a77).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.728093.

MLA Handbook (7^th Edition):

Abdul Hamid, Mohd Faisal. “Aerodynamic models for insect flight.” 2016. Web. 20 Apr 2021.

Vancouver:

Abdul Hamid MF. Aerodynamic models for insect flight. [Internet] [Doctoral dissertation]. University of Manchester; 2016. [cited 2021 Apr 20]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/aerodynamic-models-for-insect-flight(057be27b-265a-45a0-b8d0-dc3c02a62a77).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.728093.

Council of Science Editors:

Abdul Hamid MF. Aerodynamic models for insect flight. [Doctoral Dissertation]. University of Manchester; 2016. Available from: https://www.research.manchester.ac.uk/portal/en/theses/aerodynamic-models-for-insect-flight(057be27b-265a-45a0-b8d0-dc3c02a62a77).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.728093

University of Melbourne

30. John, Nijoy. Use of multiplex-tandem polymerase chain reaction in an operational environment to assess cyanotoxins and taste and odour metabolites of cyanobacterial blooms in Victorian waters.

Degree: 2018, University of Melbourne

URL: http://hdl.handle.net/11343/219216

► Cyanobacterial blooms represent a major water quality and public health issue due to their potential to produce taste and odour (T/O) compounds, and a variety… (more)

▼ Cyanobacterial blooms represent a major water quality and public health issue due to their potential to produce taste and odour (T/O) compounds, and a variety of toxic metabolites. Monitoring and management of cyanobacterial blooms in various water resources is in turn dependent on the availability of accurate and sensitive diagnostic tools, and contemporary or prior knowledge of the regional distribution of toxin and T/O types. For example, in Victoria, Australia, there is limited knowledge of the distribution/ecology of geosmin producers, such that prioritising taxa for routine monitoring is difficult. Additionally, knowledge about the prevalence of many yet to be identified or emerging toxic cyanobacteria (eg., anatoxin producers) in Australia, remains poorly understood. Due to the many limitations of commonly used detection methods (i.e., microscopy and direct detection techniques), to identify toxic and T/O producing cyanobacteria, there is a need to develop sensitive and accurate diagnostic tools. PCR-based tools have shown potential to accurately identify toxic or T/O producing cyanobacteria; however, they have important limitations for routine monitoring. Although multiplex-tandem PCR (MT-PCR) tool has shown significant potential to accurately detect four major cyanotoxins (i.e., MC, NOD, STX and CYN) in Australia, it requires additional field testing and further, this tool is not presently suitable to detect anatoxin and geosmin-producing cyanobacteria. The work presented in this study used PCR-based genetic screening tools (i.e., conventional PCR, nested-PCR or MT-PCR) for accurate diagnosis of cyanotoxins and geosmin-producing cyanobacteria on environmental cyanobacterial bloom samples collected from various parts of Victoria, Australia, over a period of eight years (i.e., from 2010 to 2018). The study also employed metagenomic approaches (eg., Illumina MiSeq and PacBio) using biomarker genes [eg., 16S ribosomal RNA (16S rRNA) and phycocyanin intergenic spacer sequence (PC-IGS or cpcBA-IGS)] to elucidate the community structure of a recent (i.e., 2016) cyanobacterial bloom in the Murray River, Victoria, Australia. Based on conventional PCR-based genetic screening (using three different primer pairs) of more than 250 cyanobacteria bloom samples collected over a period of six years (i.e., 2010-2016), we detected Dolichospermum ucrainicum as the major geosmin producer in 87% of sequenced samples. Using these data, we developed a novel, small amplicon PCR primer pair capable to broadly identify all geosmin-producing cyanobacteria identified in the current study using a single standardised protocol. Additionally, genetic screening using nested-PCR on samples (n=226) collected from 2010-2017 revealed the presence and distribution of several anatoxin-producing cyanobacteria, including Cuspidothrix issatschenkoi, Aphanizomenon sp., Dolichospermum sp., at an overall sample prevalence of 30.1%. An overwhelming majority (86.8%) of anatoxin positive nested-PCR detections were from samples collected from 2016 to…

Subjects/Keywords: cyanobacteria; cyanotoxins; geosmin; multiplex-tandem PCR; metagenomics

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APA (6^th Edition):

John, N. (2018). Use of multiplex-tandem polymerase chain reaction in an operational environment to assess cyanotoxins and taste and odour metabolites of cyanobacterial blooms in Victorian waters. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/219216

Chicago Manual of Style (16^th Edition):

John, Nijoy. “Use of multiplex-tandem polymerase chain reaction in an operational environment to assess cyanotoxins and taste and odour metabolites of cyanobacterial blooms in Victorian waters.” 2018. Doctoral Dissertation, University of Melbourne. Accessed April 20, 2021. http://hdl.handle.net/11343/219216.

MLA Handbook (7^th Edition):

John, Nijoy. “Use of multiplex-tandem polymerase chain reaction in an operational environment to assess cyanotoxins and taste and odour metabolites of cyanobacterial blooms in Victorian waters.” 2018. Web. 20 Apr 2021.

Vancouver:

John N. Use of multiplex-tandem polymerase chain reaction in an operational environment to assess cyanotoxins and taste and odour metabolites of cyanobacterial blooms in Victorian waters. [Internet] [Doctoral dissertation]. University of Melbourne; 2018. [cited 2021 Apr 20]. Available from: http://hdl.handle.net/11343/219216.

Council of Science Editors:

John N. Use of multiplex-tandem polymerase chain reaction in an operational environment to assess cyanotoxins and taste and odour metabolites of cyanobacterial blooms in Victorian waters. [Doctoral Dissertation]. University of Melbourne; 2018. Available from: http://hdl.handle.net/11343/219216

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Open Access Theses and Dissertations