subject:(tDCS)

University of Newcastle

1. Knechtel, Lilly. Transcranial direct current stimulation effects on auditory event-related potentials in schizophrenia.

Degree: PhD, 2015, University of Newcastle

URL: http://hdl.handle.net/1959.13/1059906

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Research Doctorate - Doctor of Philosophy (PhD)

Transcranial direct current stimulation (tDCS) is considered a non-invasive and well-tolerated brain stimulation technique with very few adverse… (more)

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Research Doctorate - Doctor of Philosophy (PhD)

Transcranial direct current stimulation (tDCS) is considered a non-invasive and well-tolerated brain stimulation technique with very few adverse side effects. Importantly, tDCS does not directly evoke neuronal firing (as induced by electroconvulsive or transcranial magnetic stimulation), but instead alters the resting membrane potential of pre- and post-synaptic neurons dependent on the current polarity in the stimulated brain region. Animal studies suggest that changes in long-term potentiation occur via glutamate release in response to anodal tDCS, thereby affecting learning and memory. In clinical studies, a current not exceeding 2 mA/cm2 is applied for 10–30 min via electrodes placed above the target brain region. To date, a number of clinical studies have reported some promising effects when treating patients with depression, chronic pain, schizophrenia, dementia, Parkinson’s disease and cerebral stroke. However, appropriately designed randomized controlled clinical trials are scarce and reported intervention effect sizes only vary from small to moderate, with little evidence for sustained long-term effects. Particularly the effects of tDCS on human cognition are poorly understood, including the underlying neurophysiological mechanisms. Hence, the current thesis investigated the effects of anodal tDCS over the prefrontal cortex on auditory event-related potentials (ERPs) and related changes in the neurochemistry of the stimulated brain tissue with high-field proton magnetic resonance spectroscopy (MRS) in healthy volunteers. The effects of a single session of 20 min of 2 mA left-prefrontal anodal versus sham stimulation on auditory ERPs was investigated by employing a randomized single-blind crossover design. Stimulation effects on cortical glutamate (Glu) and glutamine (Glx) levels were subsequently measured in a 3 Tesla MRS scan. tDCS was associated with a significant increase of N1 amplitudes while smaller P3b amplitudes correlated with higher cortical Glu and Glx levels in the stimulated brain area when performing an auditory go/no-go discrimination task. tDCS did not change mismatch negativity, nor task performance or cortical Glu/Glx levels. Cortical Glu/Glx levels and N1 amplitudes were both depended on stimulation order (“sham” vs “active”). Notwithstanding, increased N1 amplitudes with anodal tDCS support the notion of increased cortical excitability, thereby potentially supporting impaired cognitive processes in neuropsychiatric conditions. Hence, the effects of tDCS on ERPs were also investigated in schizophrenia. Schizophrenia patients usually present with significantly smaller N1, MMN and P3 amplitudes when compared to their healthy counterparts. This was also confirmed in the current study. However, anodal tDCS had no effect on any ERPs in schizophrenia patients and did not affect the performance in the go/no go task. In fact, both groups, healthy controls and schizophrenia patients, performed equally well on this task. Taken together, these…

Advisors/Committee Members: University of Newcastle. Faculty of Health & Medicine, School of Medicine and Public Health.

Subjects/Keywords: schizophrenia; tDCS; ERP

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APA (6^th Edition):

Knechtel, L. (2015). Transcranial direct current stimulation effects on auditory event-related potentials in schizophrenia. (Doctoral Dissertation). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/1059906

Chicago Manual of Style (16^th Edition):

Knechtel, Lilly. “Transcranial direct current stimulation effects on auditory event-related potentials in schizophrenia.” 2015. Doctoral Dissertation, University of Newcastle. Accessed January 24, 2021. http://hdl.handle.net/1959.13/1059906.

MLA Handbook (7^th Edition):

Knechtel, Lilly. “Transcranial direct current stimulation effects on auditory event-related potentials in schizophrenia.” 2015. Web. 24 Jan 2021.

Vancouver:

Knechtel L. Transcranial direct current stimulation effects on auditory event-related potentials in schizophrenia. [Internet] [Doctoral dissertation]. University of Newcastle; 2015. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/1959.13/1059906.

Council of Science Editors:

Knechtel L. Transcranial direct current stimulation effects on auditory event-related potentials in schizophrenia. [Doctoral Dissertation]. University of Newcastle; 2015. Available from: http://hdl.handle.net/1959.13/1059906

University of Illinois – Chicago

2. Leach, Ryan C. Effects of Transcranial Stimulation on Memory for Social Information in Younger and Older Adults.

Degree: 2016, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/21563

► Episodic memory decline is a normal and expected part of the aging process. However, not all types of memory show equal decline throughout the lifespan.… (more)

Subjects/Keywords: Memory; Aging; tDCS

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APA (6^th Edition):

Leach, R. C. (2016). Effects of Transcranial Stimulation on Memory for Social Information in Younger and Older Adults. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/21563

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Leach, Ryan C. “Effects of Transcranial Stimulation on Memory for Social Information in Younger and Older Adults.” 2016. Thesis, University of Illinois – Chicago. Accessed January 24, 2021. http://hdl.handle.net/10027/21563.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Leach, Ryan C. “Effects of Transcranial Stimulation on Memory for Social Information in Younger and Older Adults.” 2016. Web. 24 Jan 2021.

Vancouver:

Leach RC. Effects of Transcranial Stimulation on Memory for Social Information in Younger and Older Adults. [Internet] [Thesis]. University of Illinois – Chicago; 2016. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/10027/21563.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Leach RC. Effects of Transcranial Stimulation on Memory for Social Information in Younger and Older Adults. [Thesis]. University of Illinois – Chicago; 2016. Available from: http://hdl.handle.net/10027/21563

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Minnesota

3. Knerr, Jordan. Usability Testing For A Non-Functioning Mockup of A Tdcs Stroke therapy System.

Degree: M.S.M.E., Mechanical Engineering, 2020, University of Minnesota

URL: http://hdl.handle.net/11299/216075

► This study examined the usability of a custom telerehabilitation therapy system for adults with stroke. The system included a non-functioning mockup of a hat that… (more)

Subjects/Keywords: Stroke; tDCS; Telerehabilitation

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APA (6^th Edition):

Knerr, J. (2020). Usability Testing For A Non-Functioning Mockup of A Tdcs Stroke therapy System. (Masters Thesis). University of Minnesota. Retrieved from http://hdl.handle.net/11299/216075

Chicago Manual of Style (16^th Edition):

Knerr, Jordan. “Usability Testing For A Non-Functioning Mockup of A Tdcs Stroke therapy System.” 2020. Masters Thesis, University of Minnesota. Accessed January 24, 2021. http://hdl.handle.net/11299/216075.

MLA Handbook (7^th Edition):

Knerr, Jordan. “Usability Testing For A Non-Functioning Mockup of A Tdcs Stroke therapy System.” 2020. Web. 24 Jan 2021.

Vancouver:

Knerr J. Usability Testing For A Non-Functioning Mockup of A Tdcs Stroke therapy System. [Internet] [Masters thesis]. University of Minnesota; 2020. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/11299/216075.

Council of Science Editors:

Knerr J. Usability Testing For A Non-Functioning Mockup of A Tdcs Stroke therapy System. [Masters Thesis]. University of Minnesota; 2020. Available from: http://hdl.handle.net/11299/216075

Delft University of Technology

4. Lekkas, Konstantinos (author). A Power Efficient Multichannel Neurostimulator Based on the Ultra High Frequency Technique for Transcranial Direct Current Stimulation Applications.

Degree: 2019, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:24036fca-c87d-472d-8285-3f4f84356dd2

► Transcranial direct current stimulation (tDCS) is a noninvasive technique, allowing for the reversible modulation of activity in particular brain regions. TDCS has obtained much scientific… (more)

▼ Transcranial direct current stimulation (tDCS) is a noninvasive technique, allowing for the reversible modulation of activity in particular brain regions. TDCS has obtained much scientific interest and it promises many potential benefits to the patients. However, tDCS that is performed today is almost the same with the method that was used 20 years ago (applying 2 mA current, during a 20 min session, using two large surface sponge electrodes). The tDCS module of the future must be characterized by increased portability, battery life and focality. Many commercially available devices have very low power efficiency, leaving space for the design of low power consumption tDCS devices. Power efficient tDCS modules will also need lower battery capacity and thus lighter batteries, increasing the portability of the system. Regarding focality, there is increased interest from the researchers and physicians for multichannel devices that use small diameter electrodes. These devices can increase the focality and the accuracy of the delivered currents offering more targeted therapies. In this thesis, the realization of a novel, low power, multichannel stimulation module, made with discrete components, which uses the ultra high frequency (UHF) technique for tDCS applications is implemented. With this approach, the technological benefits of the UHF stimulation technique, regarding increased multichannel power efficiency, are derived, combined with a cost effective, low scale production method. Moreover, contrary to previous integrated circuit (IC) realizations, current control feedback is added to the system. In this thesis, three prototypes are fabricated, with the last one being an eight channel module that can be supplied from a 3.5 V battery and has a very linear relationship between the selected DAC’s codes and the output delivered current and, at the same time, being able to stimulate a wide range of loads (0.148 - 10.11 kΩ) up to 2 mA. Furthermore, the employed novel boost technique shows 40.57% maximum improvement of the power efficiency, compared to the use of a conventional buck-boost converter. Moreover, the feedback system shows significant robustness, achieving only 7.6% output current divergence for 6731% change of the output load’s impedance. The module has 4 μΑ resolution, which is translated to 0.2% of the maximum delivered current. Except from the high resolution, the system also has a fast transient response, which is less than 2.1 ms. Additionally, when one channel is active, the stimulator shows 43.84% maximum power efficiency. The aforementioned power efficiency is 23.49% higher than the maximum efficiency of state of the art adaptive voltage current source implementations. Additionally, the multichannel system was tested in real life scenarios and its efficiency was compared to a fixed voltage current source module. The system achieved 37.57%, 45.47% and 11.59% power efficiency improvements for two, four and eight channels respectively. Hence, a novel, multichannel… Advisors/Committee Members: Serdijn, Wouter (mentor), French, Paddy (graduation committee), Giagka, Vasso (graduation committee), Dankelman, Jenny (graduation committee), Peuscher, Jan (graduation committee), Delft University of Technology (degree granting institution).

Subjects/Keywords: stimulator; tDCS; multichannel

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lekkas, K. (. (2019). A Power Efficient Multichannel Neurostimulator Based on the Ultra High Frequency Technique for Transcranial Direct Current Stimulation Applications. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:24036fca-c87d-472d-8285-3f4f84356dd2

Chicago Manual of Style (16^th Edition):

Lekkas, Konstantinos (author). “A Power Efficient Multichannel Neurostimulator Based on the Ultra High Frequency Technique for Transcranial Direct Current Stimulation Applications.” 2019. Masters Thesis, Delft University of Technology. Accessed January 24, 2021. http://resolver.tudelft.nl/uuid:24036fca-c87d-472d-8285-3f4f84356dd2.

MLA Handbook (7^th Edition):

Lekkas, Konstantinos (author). “A Power Efficient Multichannel Neurostimulator Based on the Ultra High Frequency Technique for Transcranial Direct Current Stimulation Applications.” 2019. Web. 24 Jan 2021.

Vancouver:

Lekkas K(. A Power Efficient Multichannel Neurostimulator Based on the Ultra High Frequency Technique for Transcranial Direct Current Stimulation Applications. [Internet] [Masters thesis]. Delft University of Technology; 2019. [cited 2021 Jan 24]. Available from: http://resolver.tudelft.nl/uuid:24036fca-c87d-472d-8285-3f4f84356dd2.

Council of Science Editors:

Lekkas K(. A Power Efficient Multichannel Neurostimulator Based on the Ultra High Frequency Technique for Transcranial Direct Current Stimulation Applications. [Masters Thesis]. Delft University of Technology; 2019. Available from: http://resolver.tudelft.nl/uuid:24036fca-c87d-472d-8285-3f4f84356dd2

Erasmus University Rotterdam

5. M.C. Verhage (Claire). Neuromodulation of the Cognitive Cerebellum.

Degree: 2018, Erasmus University Rotterdam

URL: http://hdl.handle.net/1765/104022

► In this thesis, the effect of non-invasive neurostimulation on motor and cognitive performance was investigated, taking an implicit-explicit notion into account. Results were mixed, varying… (more)

Subjects/Keywords: tDCS; neuromodulation; neurostimulation; cognition; cerebellum

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APA (6^th Edition):

(Claire), M. V. (2018). Neuromodulation of the Cognitive Cerebellum. (Thesis). Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/104022

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

(Claire), M.C. Verhage. “Neuromodulation of the Cognitive Cerebellum.” 2018. Thesis, Erasmus University Rotterdam. Accessed January 24, 2021. http://hdl.handle.net/1765/104022.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

(Claire), M.C. Verhage. “Neuromodulation of the Cognitive Cerebellum.” 2018. Web. 24 Jan 2021.

Vancouver:

(Claire) MV. Neuromodulation of the Cognitive Cerebellum. [Internet] [Thesis]. Erasmus University Rotterdam; 2018. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/1765/104022.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

(Claire) MV. Neuromodulation of the Cognitive Cerebellum. [Thesis]. Erasmus University Rotterdam; 2018. Available from: http://hdl.handle.net/1765/104022

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Tampere University

6. Havela, Riikka. Effect of Frontal Transcranial Direct Current Stimulation on Word Fluency in Healthy Adults .

Degree: 2020, Tampere University

URL: https://trepo.tuni.fi/handle/10024/119998

► Introduction: Transcranial direct current stimulation (tDCS) is a noninvasive and well tolerated method for stimulating the brain in a subthreshold manner. It has shown some… (more)

▼ Introduction: Transcranial direct current stimulation (tDCS) is a noninvasive and well tolerated method for stimulating the brain in a subthreshold manner. It has shown some promise e.g. in treatment of major depressive disorder. The prefrontal cortex is an interesting target for tDCS studies, since the executive functions it performs are compromised in many diseases of the brain. Verbal fluency tasks are one way of measuring executive functions, albeit inherently being a combined task that measures several other functions, such as verbal ability, as well. In this study, we wanted to explore whether tDCS targeted to the dorsolateral prefrontal cortex influences performance in phonemic and semantic word fluency tasks in healthy adults. Materials and methods: 23 healthy participants, aged 21-34 years, were randomized into two groups, one receiving active tDCS stimulation and the other one receiving sham stimulation. They performed a one-minute phonemic and semantic fluency test before (session 1) and after (session 2) performing Executive reaction time test, a computer-based test engaging several executive functions simultaneously, during which the active or sham stimulation was administered. The number of words produced during the verbal fluency tests was analyzed for the full one-minute test period, and in 15 second intervals using analysis of variance and Student’s T-test. Results: The semantic fluency task proved to be easier for the participants, as expected. There was also a tendency to perform better in session 2 (post-stimulation) than session 1 (pre-stimulation) in both fluency tasks and in both active and sham stimulation groups, implying learning. Interestingly, there was a statistically significant difference in the semantic fluency test session 2 (post-stimulation) second quarter (15-30 s from the beginning of the test) between the number of words produced by the active and sham stimulation groups with those having received tDCS producing more words. Conclusions: The results indicate significant learning in repeated verbal fluency tasks influencing the assessment of an intervention on executive functions. tDCS improved verbal fluency in the second quarter of the fluency test. We speculate based on the exponential decay curve of performance in the fluency task that the second quarter is most dependent on executive functions, and thus subtle alterations in executive functions may be more easily detected during this quarter. This is in contrast to the first quarter that relies on semiautomatic access of frequent words rather than effortful retrieval of infrequent words. Furthermore, it may be that in the third and fourth quarter vocabulary may be the limiting factor on the performance rather than the efficiency of executive functions. Thus, while caution is warranted and these preliminary results should be confirmed in future studies, it is possible that there was a subtle improvement in executive functions due to tDCS that was observed only in the second quarter of the fluency task.

Subjects/Keywords: tDCS ; prefrontal cortex ; verbal fluency

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Havela, R. (2020). Effect of Frontal Transcranial Direct Current Stimulation on Word Fluency in Healthy Adults . (Masters Thesis). Tampere University. Retrieved from https://trepo.tuni.fi/handle/10024/119998

Chicago Manual of Style (16^th Edition):

Havela, Riikka. “Effect of Frontal Transcranial Direct Current Stimulation on Word Fluency in Healthy Adults .” 2020. Masters Thesis, Tampere University. Accessed January 24, 2021. https://trepo.tuni.fi/handle/10024/119998.

MLA Handbook (7^th Edition):

Havela, Riikka. “Effect of Frontal Transcranial Direct Current Stimulation on Word Fluency in Healthy Adults .” 2020. Web. 24 Jan 2021.

Vancouver:

Havela R. Effect of Frontal Transcranial Direct Current Stimulation on Word Fluency in Healthy Adults . [Internet] [Masters thesis]. Tampere University; 2020. [cited 2021 Jan 24]. Available from: https://trepo.tuni.fi/handle/10024/119998.

Council of Science Editors:

Havela R. Effect of Frontal Transcranial Direct Current Stimulation on Word Fluency in Healthy Adults . [Masters Thesis]. Tampere University; 2020. Available from: https://trepo.tuni.fi/handle/10024/119998

7. Gozenman, Filiz. The Role of the Posterior Parietal Cortex In Working Memory.

Degree: 2015, University of Nevada – Reno

URL: http://hdl.handle.net/11714/2663

► The neural underpinnings of WM rely on the frontoparietal networks including structures in prefrontal and posterior parietal cortices (PPC). Often referred to as ‘association cortex’,… (more)

Subjects/Keywords: attention; group differences; hd-tdcs; tdcs; working memory

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APA (6^th Edition):

Gozenman, F. (2015). The Role of the Posterior Parietal Cortex In Working Memory. (Thesis). University of Nevada – Reno. Retrieved from http://hdl.handle.net/11714/2663

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gozenman, Filiz. “The Role of the Posterior Parietal Cortex In Working Memory.” 2015. Thesis, University of Nevada – Reno. Accessed January 24, 2021. http://hdl.handle.net/11714/2663.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gozenman, Filiz. “The Role of the Posterior Parietal Cortex In Working Memory.” 2015. Web. 24 Jan 2021.

Vancouver:

Gozenman F. The Role of the Posterior Parietal Cortex In Working Memory. [Internet] [Thesis]. University of Nevada – Reno; 2015. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/11714/2663.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gozenman F. The Role of the Posterior Parietal Cortex In Working Memory. [Thesis]. University of Nevada – Reno; 2015. Available from: http://hdl.handle.net/11714/2663

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Presbiteriana Mackenzie

8. Rodrigo Quadros Altieri Martinez. Influência da estimulação transcraniana por corrente contínua na aprendizagem motora de indivíduos saudáveis.

Degree: 2012, Universidade Presbiteriana Mackenzie

URL: http://tede.mackenzie.com.br//tde_busca/arquivo.php?codArquivo=2655

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A Estimulação Transcraniana por Corrente Contínua (ETCC) é uma ferramenta de modulação cortical não-invasiva, indolor de fácil aplicação. Seus efeitos estão atraindo enorme interesse como… (more)

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A Estimulação Transcraniana por Corrente Contínua (ETCC) é uma ferramenta de modulação cortical não-invasiva, indolor de fácil aplicação. Seus efeitos estão atraindo enorme interesse como uma ferramenta terapêutica para reabilitação motora, devido seu potencial de modular a excitabilidade local e conduzir a melhora da função motora e desempenho de uma tarefa. Aprendizagem Motora pode ser definida como a capacidade de realizar uma tarefa motora proporcionando uma melhora relativamente permanente no desempenho da mesma. O objetivo do trabalho foi investigar os efeitos da ETCC em M1 no processo de aprendizagem motora em adultos saudáveis do sexo feminino. Para isso 21 sujeitos realizaram dois tipos de tarefas motoras, TJTHF e Teste do Labirinto e ETCC em córtex motor primário. Os resultados indicaram haver uma melhora significativa do desempenho motor após estimulação anódica do córtex motor primário para o TJTHF (p<0,000001) e a ETCC catódica no córtex motor primário demonstrou dificultar o desempenho (p=0,006). Para o Teste do Labirinto não foi verificado efeito significativo da ETCC para os períodos de aquisição, transferência, retenção e retenção visual. Ao final nossos resultados mostram que ETCC anódica e catódica em córtex motor primário influencia o desempenho motor, confirmando a idéia da ETCC em cortéx motor associada à melhora da função motora.

Transcranial direct current stimulation (tDCS) is a non-invasive method to modulate brain activity. Its effects are attracting enormous interest as a therapeutic tool for motor rehabilitation. Motor learning can be defined as the ability to perform a task motor providing a relatively permanent improvement in performance thereof. This research aimed to investigate the effects of tDCS on M1 in the process of motor learning in healthy adult females. For this purpose 21 subjects performed two types of motor tasks, TJJ and Maze test and tDCS on primary motor cortex. The results indicated a significant improvement of motor performance after stimulation of the anodic to the primary motor cortex TJJ (p <0.000001) and cathodic tDCS in primary motor cortex showed hinder performance (p = 0.006). To the maze test was not significant effect of tDCS for the periods of acquisition, transfer, retention, and visual retention. At the end our results show that tDCS anode and cathode in primary motor cortex influences motor performance, confirming the idea of tDCS associated with motor function.

Advisors/Committee Members: Silvana Maria Blascovi de Assis, Paulo Sérgio Boggio, Hamilton Haddad Junior.

Subjects/Keywords: aprendizagem Motora; ETCC; motor Learning; TDCS; PSICOLOGIA

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APA (6^th Edition):

Martinez, R. Q. A. (2012). Influência da estimulação transcraniana por corrente contínua na aprendizagem motora de indivíduos saudáveis. (Thesis). Universidade Presbiteriana Mackenzie. Retrieved from http://tede.mackenzie.com.br//tde_busca/arquivo.php?codArquivo=2655

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Martinez, Rodrigo Quadros Altieri. “Influência da estimulação transcraniana por corrente contínua na aprendizagem motora de indivíduos saudáveis.” 2012. Thesis, Universidade Presbiteriana Mackenzie. Accessed January 24, 2021. http://tede.mackenzie.com.br//tde_busca/arquivo.php?codArquivo=2655.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Martinez, Rodrigo Quadros Altieri. “Influência da estimulação transcraniana por corrente contínua na aprendizagem motora de indivíduos saudáveis.” 2012. Web. 24 Jan 2021.

Vancouver:

Martinez RQA. Influência da estimulação transcraniana por corrente contínua na aprendizagem motora de indivíduos saudáveis. [Internet] [Thesis]. Universidade Presbiteriana Mackenzie; 2012. [cited 2021 Jan 24]. Available from: http://tede.mackenzie.com.br//tde_busca/arquivo.php?codArquivo=2655.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Martinez RQA. Influência da estimulação transcraniana por corrente contínua na aprendizagem motora de indivíduos saudáveis. [Thesis]. Universidade Presbiteriana Mackenzie; 2012. Available from: http://tede.mackenzie.com.br//tde_busca/arquivo.php?codArquivo=2655

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Leiden University

9. Pierse, Sandrine. Will cerebellar transcranial direct current stimulation improve cognitive function?.

Degree: 2016, Leiden University

URL: http://hdl.handle.net/1887/43871

Subjects/Keywords: tDCS; cerebellum; cognition

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APA (6^th Edition):

Pierse, S. (2016). Will cerebellar transcranial direct current stimulation improve cognitive function?. (Masters Thesis). Leiden University. Retrieved from http://hdl.handle.net/1887/43871

Chicago Manual of Style (16^th Edition):

Pierse, Sandrine. “Will cerebellar transcranial direct current stimulation improve cognitive function?.” 2016. Masters Thesis, Leiden University. Accessed January 24, 2021. http://hdl.handle.net/1887/43871.

MLA Handbook (7^th Edition):

Pierse, Sandrine. “Will cerebellar transcranial direct current stimulation improve cognitive function?.” 2016. Web. 24 Jan 2021.

Vancouver:

Pierse S. Will cerebellar transcranial direct current stimulation improve cognitive function?. [Internet] [Masters thesis]. Leiden University; 2016. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/1887/43871.

Council of Science Editors:

Pierse S. Will cerebellar transcranial direct current stimulation improve cognitive function?. [Masters Thesis]. Leiden University; 2016. Available from: http://hdl.handle.net/1887/43871

Queens University

10. Xu, Sisi. Differential contributions of the mIPS and PMd in the movement planning of reaches investigated through HD-tDCS .

Degree: Neuroscience Studies, 2016, Queens University

URL: http://hdl.handle.net/1974/15048

► To reach for a target, we must formulate a movement plan - a difference vector of the target position with respect to the starting hand… (more)

▼ To reach for a target, we must formulate a movement plan - a difference vector of the target position with respect to the starting hand position. While it is known that the medial part of the intraparietal sulcus (mIPS) and the dorsal premotor (PMd) activity reflects aspects of a kinematic plan for a reaching movement, it is unclear whether or how the two regions may differ. We investigated the functional roles of the mIPS and PMd in the planning of reaching movements using high definition transcranial direct current stimulation (HD-tDCS) and examined changes in horizontal endpoint error when participants were subjected to anodal and cathodal stimulation. The left mIPS and PMd were functionally localized with fMRI in each participant using an interleaved center-out pointing and saccade task and mapped onto the scalp using Brainsight. We adopted a randomized, single-blind design and applied anodal and cathodal stimulation (2mA for 20 min; 3cm radius 4x1 electrode placement) during 4 separate visits scheduled at least a week apart. Each participant performed 250 baseline, stimulation, and post-stimulation memory-guided reaches starting from one of two initial hand positions (IHPs) to one of 4 briefly flashed targets (20 cm distant, 5 cm apart horizontally) while fixating on a straight-ahead cross located at the target line. Separate 2-way repeated measures ANOVAs of horizontal endpoint error difference after cathodal tDCS at each stimulation site revealed a significant IHP by target position interaction effect at the left mIPS, and significant IHP and target main effects at the left PMd. Behaviorally, these effects corresponded to IHP-dependent contractions after cathodal mIPS tDCS and IHP-independent contractions after cathodal PMd tDCS. These results suggest that the movement vector is not yet formed at the input level of mIPS, but is encoded at the input of PMd. These results also indicate that tDCS is a viable, useful method in investigating movement planning properties through temporary perturbations of the system.

Subjects/Keywords: HD-tDCS ; movement planning ; PMd ; reaching ; mIPS

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Xu, S. (2016). Differential contributions of the mIPS and PMd in the movement planning of reaches investigated through HD-tDCS . (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/15048

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Xu, Sisi. “Differential contributions of the mIPS and PMd in the movement planning of reaches investigated through HD-tDCS .” 2016. Thesis, Queens University. Accessed January 24, 2021. http://hdl.handle.net/1974/15048.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Xu, Sisi. “Differential contributions of the mIPS and PMd in the movement planning of reaches investigated through HD-tDCS .” 2016. Web. 24 Jan 2021.

Vancouver:

Xu S. Differential contributions of the mIPS and PMd in the movement planning of reaches investigated through HD-tDCS . [Internet] [Thesis]. Queens University; 2016. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/1974/15048.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Xu S. Differential contributions of the mIPS and PMd in the movement planning of reaches investigated through HD-tDCS . [Thesis]. Queens University; 2016. Available from: http://hdl.handle.net/1974/15048

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Boston University

11. McGillen, Patrick Kennedy. Determining the cellular basis of transcranial brain stimulation in mitigating the effects of ischemic brain injury.

Degree: MS, Medical Sciences, 2016, Boston University

URL: http://hdl.handle.net/2144/16989

► Focal ischemic stroke cause alterations of the brain’s inherent excitation – inhibition balance in neurons around the infarct, and in distant areas connected to the… (more)

▼ Focal ischemic stroke cause alterations of the brain’s inherent excitation – inhibition balance in neurons around the infarct, and in distant areas connected to the damaged region. These widespread changes contribute to symptomatology and reduce activity in areas that have the capacity to functionally compensate for the effect of the focal lesion. The ability to control excitability in specific brain areas after stroke could restore normal excitability and promote functional recovery. Non-invasive brain stimulation techniques have the potential to produce targeted change in excitability in neural tissue. One such technique, transcranial direct current stimulation (tDCS), modulates cortical excitability in a lasting, polarity-specific manner. The hypotheses of this study were that 1) focal unilateral ischemic damage to the parietal cortex would produce repeatable alterations in the inhibitory network in ipsilateral and contralateral brain areas, and 2) tDCS applied after ischemia would alter the size of the lesion change the inhibitory networks. A unilateral non-invasive photothrombic stroke was produced under isoflurane anesthesia, and cathodal (n=5), anodal (n=5), or sham (n=6) tDCS (5 minutes, 10.0mA) was subsequently administered to the site. Four additional animals were assigned to sham operation groups that did not undergo photothrombosis. Animals recovered for 24 hours, after which their brains were cut, and prepared for single- and double-labeled immunocytochemistry to analyze the functional activity of excitatory neurons and inhibitory interneurons, astrogliosis, and neuronal degeneration. Results demonstrate that unilateral ischemic injury does not produce a hyperexcitability of the contralateral cortex or otherwise alter the activation status of immunohistochemcially-defined inhibitory or disinhibitory neurons, a finding discrepant with the rationale used to treat ischemic injury in humans. Similar findings were identified in the ipsilateral cortex. Results did show that ischemia activated white matter neurons, as well as neurons in layer III ipsilateral to the lesion extending 1-2mm into the intact cortex. Neurons degenerating as observed by Fluoro-Jade B revealed clusters of pyramidal-shaped neurons in layer V which extended quite far from the lesion site. Addition of cathodal, but not anodal tDCS produced an overall decrease in the lesion size, but this decrease was not statistically reliable. Stimulation also did not obviously alter the activation status of inhibitory or disinhibitory neurons. Both types of stimulation prevented the appearance of degenerating cells in layer V, and anodal tDCS reduced the activation of excitatory layer III excitatory neurons. These findings illustrate the utility of using tDCS during the production of a lesion to mitigate the size and impact of lesion and raises questions on the rationale rationale for applying brain stimulation to the contralesional cortex to treat stroke, at least in the acute stage. Finally, the series of studies here illustrate the…

Subjects/Keywords: Neurosciences; Stroke; tDCS; Diaschisis; Transneuronal degeneration

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

McGillen, P. K. (2016). Determining the cellular basis of transcranial brain stimulation in mitigating the effects of ischemic brain injury. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/16989

Chicago Manual of Style (16^th Edition):

McGillen, Patrick Kennedy. “Determining the cellular basis of transcranial brain stimulation in mitigating the effects of ischemic brain injury.” 2016. Masters Thesis, Boston University. Accessed January 24, 2021. http://hdl.handle.net/2144/16989.

MLA Handbook (7^th Edition):

McGillen, Patrick Kennedy. “Determining the cellular basis of transcranial brain stimulation in mitigating the effects of ischemic brain injury.” 2016. Web. 24 Jan 2021.

Vancouver:

McGillen PK. Determining the cellular basis of transcranial brain stimulation in mitigating the effects of ischemic brain injury. [Internet] [Masters thesis]. Boston University; 2016. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/2144/16989.

Council of Science Editors:

McGillen PK. Determining the cellular basis of transcranial brain stimulation in mitigating the effects of ischemic brain injury. [Masters Thesis]. Boston University; 2016. Available from: http://hdl.handle.net/2144/16989

George Mason University

12. Falcone, Brian Louis. Using simultaneous tdcs and fmri to investigate how brain stimulation enhances complex perceptual learning through modulation of task-relevant brain networks .

Degree: 2016, George Mason University

URL: http://hdl.handle.net/1920/10553

► The purpose of this series of experiments was to determine whether transcranial direct current stimulation (tDCS) accelerates perceptual learning on complex visual attention tasks and… (more)

Subjects/Keywords: Cognitive psychology; Neurosciences; Attention; fMRI; learning; tDCS

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Falcone, B. L. (2016). Using simultaneous tdcs and fmri to investigate how brain stimulation enhances complex perceptual learning through modulation of task-relevant brain networks . (Thesis). George Mason University. Retrieved from http://hdl.handle.net/1920/10553

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Falcone, Brian Louis. “Using simultaneous tdcs and fmri to investigate how brain stimulation enhances complex perceptual learning through modulation of task-relevant brain networks .” 2016. Thesis, George Mason University. Accessed January 24, 2021. http://hdl.handle.net/1920/10553.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Falcone, Brian Louis. “Using simultaneous tdcs and fmri to investigate how brain stimulation enhances complex perceptual learning through modulation of task-relevant brain networks .” 2016. Web. 24 Jan 2021.

Vancouver:

Falcone BL. Using simultaneous tdcs and fmri to investigate how brain stimulation enhances complex perceptual learning through modulation of task-relevant brain networks . [Internet] [Thesis]. George Mason University; 2016. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/1920/10553.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Falcone BL. Using simultaneous tdcs and fmri to investigate how brain stimulation enhances complex perceptual learning through modulation of task-relevant brain networks . [Thesis]. George Mason University; 2016. Available from: http://hdl.handle.net/1920/10553

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Delft University of Technology

13. Jeukens, Floor (author). Inclusion of the lesion of chronic stroke patients into a volume conduction model: Simulating the influence of the lesion on the electric field distribution generated by tDCS.

Degree: 2019, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:9c8dd410-fed7-402a-97a4-b58ee5bf21e6

► Stroke is a cerebrovascular disorder with 15 million cases every year worldwide. The most common symptom is motor deficits. In order to overcome such symptoms,… (more)

▼ Stroke is a cerebrovascular disorder with 15 million cases every year worldwide. The most common symptom is motor deficits. In order to overcome such symptoms, the motor brain either repairs the damaged tissue or reorganises to compensate for the injured brain region. To stimulate this reorganisation transcranial Direct Current Stimulation (tDCS) is considered to be a promising thera- peutic intervention. Simulations of electric field distributions generated by tDCS currently entail individualised volume conduction models to improve tDCS. A volume conduction model includes geometry and conductivity properties of tissue types in healthy subjects. When applying existing models to chronic stroke subjects, electric field distribution patterns differ substantially compared to healthy subject distribution patterns. In current models, the lesion is not identified and acknowledged as a distinctive tissue type, as it is yet unclear what the lesion influence is. However, the lesion is a potential source of variability in desired electric field distribution which could result in different motor recovery. A volume conduction model is designed by combining the software SimNIBS, which can segment the head of healthy subjects and LINDA, able to distinguish lesion tissue of chronic stroke subjects. The location and the conductivity value of the lesion seem to influence the electric field distribution of tDCS where this individualised model is preferred. Including the lesion is an important advance towards the use of volume conduction models for chronic stroke subjects to prospectively find optimal electrode configurations, keep the safety margins and to prospectively analyse the results of tDCS. Advisors/Committee Members: Schouten, Alfred (mentor), Manoochehri, Mana (mentor), Geelen, Jinne (graduation committee), Hunyadi, Bori (graduation committee), Piastra, Maria Carla (mentor), van der Cruijsen, Joris (mentor), Delft University of Technology (degree granting institution).

Subjects/Keywords: tDCS; Lesion; simulation; Volume conduction model

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APA (6^th Edition):

Jeukens, F. (. (2019). Inclusion of the lesion of chronic stroke patients into a volume conduction model: Simulating the influence of the lesion on the electric field distribution generated by tDCS. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:9c8dd410-fed7-402a-97a4-b58ee5bf21e6

Chicago Manual of Style (16^th Edition):

Jeukens, Floor (author). “Inclusion of the lesion of chronic stroke patients into a volume conduction model: Simulating the influence of the lesion on the electric field distribution generated by tDCS.” 2019. Masters Thesis, Delft University of Technology. Accessed January 24, 2021. http://resolver.tudelft.nl/uuid:9c8dd410-fed7-402a-97a4-b58ee5bf21e6.

MLA Handbook (7^th Edition):

Jeukens, Floor (author). “Inclusion of the lesion of chronic stroke patients into a volume conduction model: Simulating the influence of the lesion on the electric field distribution generated by tDCS.” 2019. Web. 24 Jan 2021.

Vancouver:

Jeukens F(. Inclusion of the lesion of chronic stroke patients into a volume conduction model: Simulating the influence of the lesion on the electric field distribution generated by tDCS. [Internet] [Masters thesis]. Delft University of Technology; 2019. [cited 2021 Jan 24]. Available from: http://resolver.tudelft.nl/uuid:9c8dd410-fed7-402a-97a4-b58ee5bf21e6.

Council of Science Editors:

Jeukens F(. Inclusion of the lesion of chronic stroke patients into a volume conduction model: Simulating the influence of the lesion on the electric field distribution generated by tDCS. [Masters Thesis]. Delft University of Technology; 2019. Available from: http://resolver.tudelft.nl/uuid:9c8dd410-fed7-402a-97a4-b58ee5bf21e6

University of New Mexico

14. Coffman, Brian. INCREASING YOUR BRAIN POTENTIAL: TRANSCRANIAL DIRECT CURRENT STIMULATION FOR ENHANCEMENT OF BEHAVIOR AND EVENT-RELATED POTENTIALS IN TESTS OF ATTENTION AND IMPUSLIVITY.

Degree: Psychology, 2014, University of New Mexico

URL: http://hdl.handle.net/1928/24301

► Cognitive control of attention and decision making is a defining feature of the human intellect. Our ancestors survival in the past and our success as… (more)

Subjects/Keywords: tDCS; EEG; ERP; Cognitive Control; Attention; Impulsiveness

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APA (6^th Edition):

Coffman, B. (2014). INCREASING YOUR BRAIN POTENTIAL: TRANSCRANIAL DIRECT CURRENT STIMULATION FOR ENHANCEMENT OF BEHAVIOR AND EVENT-RELATED POTENTIALS IN TESTS OF ATTENTION AND IMPUSLIVITY. (Doctoral Dissertation). University of New Mexico. Retrieved from http://hdl.handle.net/1928/24301

Chicago Manual of Style (16^th Edition):

Coffman, Brian. “INCREASING YOUR BRAIN POTENTIAL: TRANSCRANIAL DIRECT CURRENT STIMULATION FOR ENHANCEMENT OF BEHAVIOR AND EVENT-RELATED POTENTIALS IN TESTS OF ATTENTION AND IMPUSLIVITY.” 2014. Doctoral Dissertation, University of New Mexico. Accessed January 24, 2021. http://hdl.handle.net/1928/24301.

MLA Handbook (7^th Edition):

Coffman, Brian. “INCREASING YOUR BRAIN POTENTIAL: TRANSCRANIAL DIRECT CURRENT STIMULATION FOR ENHANCEMENT OF BEHAVIOR AND EVENT-RELATED POTENTIALS IN TESTS OF ATTENTION AND IMPUSLIVITY.” 2014. Web. 24 Jan 2021.

Vancouver:

Coffman B. INCREASING YOUR BRAIN POTENTIAL: TRANSCRANIAL DIRECT CURRENT STIMULATION FOR ENHANCEMENT OF BEHAVIOR AND EVENT-RELATED POTENTIALS IN TESTS OF ATTENTION AND IMPUSLIVITY. [Internet] [Doctoral dissertation]. University of New Mexico; 2014. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/1928/24301.

Council of Science Editors:

Coffman B. INCREASING YOUR BRAIN POTENTIAL: TRANSCRANIAL DIRECT CURRENT STIMULATION FOR ENHANCEMENT OF BEHAVIOR AND EVENT-RELATED POTENTIALS IN TESTS OF ATTENTION AND IMPUSLIVITY. [Doctoral Dissertation]. University of New Mexico; 2014. Available from: http://hdl.handle.net/1928/24301

University of New Mexico

15. Gibson, Benjamin C. Understanding the Learning Benefits Associated with Transcranial Direct Current Simulation of the Right Ventrolateral Prefrontal Cortex.

Degree: Psychology, 2019, University of New Mexico

URL: https://digitalrepository.unm.edu/psy_etds/282

► Previous work has demonstrated that anodal transcranial direct current stimulation (tDCS) applied to the right ventrolateral prefrontal cortex (rVLPFC) is capable of accelerating learning… (more)

▼ Previous work has demonstrated that anodal transcranial direct current stimulation (tDCS) applied to the right ventrolateral prefrontal cortex (rVLPFC) is capable of accelerating learning of a threat identification and classification task. However, questions remain as to the cognitive mechanisms underlying this effect, and whether the observed tDCS mediated learning is specific to threatening stimuli or, rather, a more generalizable learning processes. The goal of the current project was to isolate specific aspects of the threat detection task in order to exemplify previous findings. A number of pre-test measures were included to attempt to decipher the characteristics of subjects who are most likely to benefit from stimulation. A novel classification task was devised, during which subjects learned to classify pictures of European streets into two categories using two rules. Fifty-four subjects were randomly assigned to receive 30 minutes of anodal (n = 18), cathodal (n = 18), or sham (n = 18) tDCS. A linear mixed model revealed a significant interaction between condition and training block in performance increases after training (p = 0.002). Compared to a 4.2% increase in sham subjects, anodal tDCS increased categorization accuracy by 20.6% (d = 1.71) and cathodal tDCS by 14.4% (d = 1.16). A logistic regression was run to predict rule learning in the experimental task using pre-test measures as predictors, with the final model predicting rule learning group by 75.9 %. Overall, these results provide further evidence for the capacity of tDCS applied to rVLPFC to enhance learning, showing greater than quadrupling of performance in a difficult novel classification task. These data suggest a generalized learning enhancement, such that other learning tasks may also benefit from this tDCS protocol. Additionally, the results point to ways in which individual characteristics might influence subsequent tDCS-mediated learning. Advisors/Committee Members: Vincent P. Clark, Ph.D., Katie Witkiewitz Ph.D., Eric Ruthruff, Ph.D..

Subjects/Keywords: NIBS; tDCS; Neuroplasticity; Learning; VLPFC; IFG; Psychology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gibson, B. C. (2019). Understanding the Learning Benefits Associated with Transcranial Direct Current Simulation of the Right Ventrolateral Prefrontal Cortex. (Masters Thesis). University of New Mexico. Retrieved from https://digitalrepository.unm.edu/psy_etds/282

Chicago Manual of Style (16^th Edition):

Gibson, Benjamin C. “Understanding the Learning Benefits Associated with Transcranial Direct Current Simulation of the Right Ventrolateral Prefrontal Cortex.” 2019. Masters Thesis, University of New Mexico. Accessed January 24, 2021. https://digitalrepository.unm.edu/psy_etds/282.

MLA Handbook (7^th Edition):

Gibson, Benjamin C. “Understanding the Learning Benefits Associated with Transcranial Direct Current Simulation of the Right Ventrolateral Prefrontal Cortex.” 2019. Web. 24 Jan 2021.

Vancouver:

Gibson BC. Understanding the Learning Benefits Associated with Transcranial Direct Current Simulation of the Right Ventrolateral Prefrontal Cortex. [Internet] [Masters thesis]. University of New Mexico; 2019. [cited 2021 Jan 24]. Available from: https://digitalrepository.unm.edu/psy_etds/282.

Council of Science Editors:

Gibson BC. Understanding the Learning Benefits Associated with Transcranial Direct Current Simulation of the Right Ventrolateral Prefrontal Cortex. [Masters Thesis]. University of New Mexico; 2019. Available from: https://digitalrepository.unm.edu/psy_etds/282

16. Truong, Dennis Q. Finite Element Study of Transcranial Direct Current Stimulation: customization of models and montages.

Degree: MS(M.S.), Biomedical Engineering, 2013, City University of New York

URL: https://academicworks.cuny.edu/cc_etds_theses/649

► Transcranial Direct Current Stimulation (tDCS) is a non-invasive neuromodulation technique that applies low amplitude current via electrodes placed on the scalp. Rather than directly… (more)

▼ Transcranial Direct Current Stimulation (tDCS) is a non-invasive neuromodulation technique that applies low amplitude current via electrodes placed on the scalp. Rather than directly eliciting a neuronal response, tDCS is believed to modulate excitability – encouraging or suppressing activity in regions of the brain depending on the polarity of stimulation. The particular application of tDCS is often determined by the electrode configuration and intensity of stimulation. MRI-derived finite element models have been developed to analyze the effect of these parameters allowing novel electrode configurations to be tested in subject specific models. By creating a subject specific model of an obese subject, the effect of fat on tDCS was examined. The inclusion of fat into the model led to an increase in cortical electric field intensity. To further investigate the influence of fat the conductivity was varied from that of skull to that of skin. Cortical electric field intensity did not change monotonically with fat conductivity. It was postulated that this may be due to a shunting effect both when the shell of fat surrounding the skull is too resistive for penetration and when the fat is so conductive as to lead current around rather than through the head. The effect of electrode positioning was then examined in a new 2x1 Hybrid montage utilizing both HD electrodes and sponge pads. Systematically varying the location of both the anode and cathode led to changes in the electric field distribution. This is in contrast to the old heuristic convention of placing the “active” electrode over a region of interest and neglecting the influence of the “return” electrode. Lastly the radial directionality of electric field was examined in a 4x1 ring configuration. Previous models have predicted the spatial focality of the 4x1 ring configuration. Polarity specificity, the ability to selectively apply either anodal or cathodal stimulation, was demonstrated in a 4x1 montage over the motor strip. The customization of models for specific populations and montages provides new avenues for clinical practice. Advisors/Committee Members: Marom Bikson.

Subjects/Keywords: tDCS; modeling; FEM; Biomedical Engineering and Bioengineering

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APA (6^th Edition):

Truong, D. Q. (2013). Finite Element Study of Transcranial Direct Current Stimulation: customization of models and montages. (Thesis). City University of New York. Retrieved from https://academicworks.cuny.edu/cc_etds_theses/649

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Truong, Dennis Q. “Finite Element Study of Transcranial Direct Current Stimulation: customization of models and montages.” 2013. Thesis, City University of New York. Accessed January 24, 2021. https://academicworks.cuny.edu/cc_etds_theses/649.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Truong, Dennis Q. “Finite Element Study of Transcranial Direct Current Stimulation: customization of models and montages.” 2013. Web. 24 Jan 2021.

Vancouver:

Truong DQ. Finite Element Study of Transcranial Direct Current Stimulation: customization of models and montages. [Internet] [Thesis]. City University of New York; 2013. [cited 2021 Jan 24]. Available from: https://academicworks.cuny.edu/cc_etds_theses/649.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Truong DQ. Finite Element Study of Transcranial Direct Current Stimulation: customization of models and montages. [Thesis]. City University of New York; 2013. Available from: https://academicworks.cuny.edu/cc_etds_theses/649

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New South Wales

17. Nikolin, Stevan. Developing transcranial direct current stimulation as a neuromodulatory tool: critical considerations on dose, prefrontal stimulation, and safety.

Degree: Psychiatry, 2018, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/61501 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:56187/SOURCE02?view=true

► Transcranial direct current stimulation (tDCS) is a mild form of non-invasive brain stimulation, which involves the use of a weak electric current passed between electrodes… (more)

▼ Transcranial direct current stimulation (tDCS) is a mild form of non-invasive brain stimulation, which involves the use of a weak electric current passed between electrodes placed on the scalp to modulate brain activity. It is an emerging technique that shows promise for the treatment of a variety of neuropsychiatric disorders, including depression. However, several critical gaps in knowledge remain, including the safety of repeated sessions of tDCS delivered over a course of treatment, optimal parameters of use, and identification of simple physiological markers of response to stimulation. The overarching aim of this thesis is to address these gaps and aid in the development of tDCS as a neuromodulatory tool and clinical intervention. This was addressed through studies in healthy participants and through a systematic review and meta-analysis of the existing tDCS safety literature.Study 1 examined whether repeated sessions of tDCS increase the likelihood of adverse events using a meta-analytic approach. Results from this study suggest that repeated sessions do not increase risk of side effects, lending further support in favour of the safety profile of tDCS. Study 2 assessed the dose-response curve of tDCS in healthy participants for enhancement of working memory. Findings suggest that none of the current intensities examined significantly improved cognitive performance. However, neurophysiological outcome measures revealed significant effects of stimulation, with the largest effect size obtained using 1mA stimulation intensity.Study 3 explored the use of a physiological biomarker of autonomic activity, heart rate variability, to objectively measure the neuromodulatory effects of tDCS on cortical activity following a single session of prefrontal stimulation. Results showed that parasympathetic activity increased during and immediately following tDCS, providing evidence that prefrontal cortex functioning is indeed modulated by tDCS, and can be assessed using a simple measure collected from heart rate data. In summary, the studies presented in this thesis contribute to the growing development of tDCS as a neuromodulatory and clinical tool. Advisors/Committee Members: Loo, Colleen, Psychiatry, Faculty of Medicine, UNSW, Martin, Donel, Psychiatry, Faculty of Medicine, UNSW, Boonstra, Tjeerd, Psychiatry, Faculty of Medicine, UNSW.

Subjects/Keywords: Working Memory; tDCS; Safety; Heart Rate Variability

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nikolin, S. (2018). Developing transcranial direct current stimulation as a neuromodulatory tool: critical considerations on dose, prefrontal stimulation, and safety. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/61501 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:56187/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Nikolin, Stevan. “Developing transcranial direct current stimulation as a neuromodulatory tool: critical considerations on dose, prefrontal stimulation, and safety.” 2018. Doctoral Dissertation, University of New South Wales. Accessed January 24, 2021. http://handle.unsw.edu.au/1959.4/61501 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:56187/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Nikolin, Stevan. “Developing transcranial direct current stimulation as a neuromodulatory tool: critical considerations on dose, prefrontal stimulation, and safety.” 2018. Web. 24 Jan 2021.

Vancouver:

Nikolin S. Developing transcranial direct current stimulation as a neuromodulatory tool: critical considerations on dose, prefrontal stimulation, and safety. [Internet] [Doctoral dissertation]. University of New South Wales; 2018. [cited 2021 Jan 24]. Available from: http://handle.unsw.edu.au/1959.4/61501 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:56187/SOURCE02?view=true.

Council of Science Editors:

Nikolin S. Developing transcranial direct current stimulation as a neuromodulatory tool: critical considerations on dose, prefrontal stimulation, and safety. [Doctoral Dissertation]. University of New South Wales; 2018. Available from: http://handle.unsw.edu.au/1959.4/61501 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:56187/SOURCE02?view=true

18. Geiger, Maxime. Etude des effets de la stimulation électrique transcrânienne en courant continu (tDCS) sur la fonction motrice volontaire et semi-automatique chez des patients hémiparétiques post AVC : Impact of transcranial direct curent stimulation on voluntary and semi-automatic movement in patient with stroke.

Degree: Docteur es, Sciences du sport et du mouvement humain, 2019, Université Paris-Saclay (ComUE)

URL: http://www.theses.fr/2019SACLS072

►

Chez les patients hémiparétiques chroniques, la tDCS a été testée sur diverses tâches du membre inférieur, montrant des résultats intéressants, mais parfois contradictoires. Cependant, les… (more)

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Chez les patients hémiparétiques chroniques, la tDCS a été testée sur diverses tâches du membre inférieur, montrant des résultats intéressants, mais parfois contradictoires. Cependant, les effets de la tDCS sur la fonction motrice volontaire (extension de genou) et semi-automatique (locomotion) chez des patients hémiparétiques ne sont pas encore totalement connus. L’objet de ce travail était d’évaluer contre placébo les effets de la tDCS en polarité anodale sur les fonctions motrices volontaires et semi-automatiques, chez des patients hémiparétiques. L’étude comporte deux parties : la première a pour but d’évaluer l’effet contre placébo de la tDCS bilatérale sur la force volontaire maximale du quadriceps parétique par isocinétisme, la seconde a pour objectif d’étudier les effets contre placébo des effets de la tDCS unilatérale sur la marche par analyse tridimensionnelle du mouvement. Les résultats ont montré une absence d’effet de la tDCS sur les deux types de mouvements étudiés. De plus, la tDCS n’a pas eu d’effet sur la spasticité du quadriceps ni sur la performance aux tests fonctionnels des patients hémiparétiques. Cela suggère qu’il n’y a pas d’intérêt à l’utilisation de la tDCS bilatérale pour améliorer une performance motrice maximale (l’extension de genou) ni de la tDCS unilatérale pour améliorer un mouvement semi-automatique (la locomotion) chez les patients hémiparétiques chroniques. Les perspectives envisagées sont de reconduire ces expérimentations chez un groupe homogène de patients hémiparétiques en phase aigüe ou subaigüe afin de potentialiser les phénomènes plastiques post-lésionnels. Ceci permettra de renforcer ou non l’intérêt de l’utilisation de la tDCS chez les patients hémiparétiques afin d’améliorer leurs performances motrices.

In chronic hemiparetic patients, the use of tDCS has been tested on various lower limb tasks, showing interesting but sometimes contradictory results. However, the effects of tDCS on voluntary (knee extension) and semi-automatic (locomotion) motor function in hemiparetic patients are not yet fully known. The purpose of this work was to quantify the effects of tDCS in anodal polarity on the voluntary and semi-automatic motor functions in placebo-controlled studies. The study is divided into two parts: the first aims to evaluate the effect against placebo of bilateral tDCS on the maximal voluntary force of the paretic quadriceps by isokinetic assessment, the second aims to study the effects against placebo of unilateral tDCS on the gait of chronic hemiparetic patients, assessed by three-dimensional gait analysis. The results showed an absence of effect of tDCS on the two types of movements studied. In addition, tDCS had no effect on quadriceps spasticity or functional test performance in hemiparetic patients. This suggests that there is no interest in using bilateral tDCS to improve maximal motor performance (knee extension) or unilateral tDCS to improve semi-automatic movement (locomotion) in chronic hemiparetic patients. The envisaged perspectives are to continue these…

Advisors/Committee Members: Roche, Nicolas (thesis director), Do, Manh-Cuong (thesis director).

Subjects/Keywords: AVC; TDCS; Locomotion; Force; Hémiparésie; Neuromodulation; Stroke; TDCS; Locomotion; Strenght; Hemiparesis; Neuromodulation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Geiger, M. (2019). Etude des effets de la stimulation électrique transcrânienne en courant continu (tDCS) sur la fonction motrice volontaire et semi-automatique chez des patients hémiparétiques post AVC : Impact of transcranial direct curent stimulation on voluntary and semi-automatic movement in patient with stroke. (Doctoral Dissertation). Université Paris-Saclay (ComUE). Retrieved from http://www.theses.fr/2019SACLS072

Chicago Manual of Style (16^th Edition):

Geiger, Maxime. “Etude des effets de la stimulation électrique transcrânienne en courant continu (tDCS) sur la fonction motrice volontaire et semi-automatique chez des patients hémiparétiques post AVC : Impact of transcranial direct curent stimulation on voluntary and semi-automatic movement in patient with stroke.” 2019. Doctoral Dissertation, Université Paris-Saclay (ComUE). Accessed January 24, 2021. http://www.theses.fr/2019SACLS072.

MLA Handbook (7^th Edition):

Geiger, Maxime. “Etude des effets de la stimulation électrique transcrânienne en courant continu (tDCS) sur la fonction motrice volontaire et semi-automatique chez des patients hémiparétiques post AVC : Impact of transcranial direct curent stimulation on voluntary and semi-automatic movement in patient with stroke.” 2019. Web. 24 Jan 2021.

Vancouver:

Geiger M. Etude des effets de la stimulation électrique transcrânienne en courant continu (tDCS) sur la fonction motrice volontaire et semi-automatique chez des patients hémiparétiques post AVC : Impact of transcranial direct curent stimulation on voluntary and semi-automatic movement in patient with stroke. [Internet] [Doctoral dissertation]. Université Paris-Saclay (ComUE); 2019. [cited 2021 Jan 24]. Available from: http://www.theses.fr/2019SACLS072.

Council of Science Editors:

Geiger M. Etude des effets de la stimulation électrique transcrânienne en courant continu (tDCS) sur la fonction motrice volontaire et semi-automatique chez des patients hémiparétiques post AVC : Impact of transcranial direct curent stimulation on voluntary and semi-automatic movement in patient with stroke. [Doctoral Dissertation]. Université Paris-Saclay (ComUE); 2019. Available from: http://www.theses.fr/2019SACLS072

19. Peanlikhit, Tanat. La stimulation transcrânienne par courant continu (tDCS) dans la dépression : ses effets comportementaux et les modifications physiologiques qui les sous-tendent chez l’animal : Transcranial Direct Current Stimulation (tDCS) in depression : Its behavioral effects and the underlying physiological modifications in animal.

Degree: Docteur es, Sciences de la vie et de la santé. Médecine, santé publique, environnement et société, 2018, Bourgogne Franche-Comté

URL: http://www.theses.fr/2018UBFCE020

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La stimulation transcrânienne par courant continu (tDCS) fait l'objet d'un regain d'intérêt par les communautés scientifique et médicale pour le traitement de diverses maladies psychiatriques,… (more)

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La stimulation transcrânienne par courant continu (tDCS) fait l'objet d'un regain d'intérêt par les communautés scientifique et médicale pour le traitement de diverses maladies psychiatriques, notamment la dépression majeure. Le but de ce travail de thèse est (i) de modéliser l'effet antidépresseur de la tDCS chez la souris saine afin d'identifier les paramètres de stimulation optimaux et de confirmer l'effet de type antidépresseur de la tDCS chez différents modèles murins de dépression et (ii) d'identifier certains des mécanismes d'action de la tDCS afin d'améliorer son utilisation et donc la prise en charge des patients. Nous avons montré que la tDCS induit un effet de type antidépresseur à long terme dans le test de nage forcée chez la souris saine, effet qui varie en intensité en fonction des paramètres de stimulation (nombre, durée, intensité et polarité de stimulation). La tDCS permet également de normaliser les comportements de type dépressifs observé chez les souris soumises à une exposition chronique à la corticostérone (hormone de stress) (modèle CORT), à des stress imprédictibles (modèle UCMS) ou à l'injection de LPS. L'analyse de l'expression du facteur de transcription précoce c-fos par immunohistochimie a permis de mettre en évidence que cet effet antidépresseur est associé à l'activation des neurones au sein de différentes structures impliquées dans la régulation émotionnelle et suggère la mise en place d'autres mécanismes (neuroplasticité?) lorsque la stimulation est répétée. De façon intéressante, la tDCS semble moduler la réponse inflammatoire induite par l'exposition chronique à des stress imprédictibles. En effet, la tDCS normalise les augmentations du nombre de cellules et des taux de globule blanc dans la rate, induites par la procédure d'UCMS et témoignant du déclanchement de la réponse inflammatoire. Ainsi ce travail participe à une meilleure compréhension des effets comportementaux de la tDCS et des phénomènes physiologiques les sous-tendant.

Transcranial direct current stimulation (tDCS) is a non-invasive method with increasing interest for the treatment of several brain disorders, such as major depression. Despite great enthusiasm and promising results, some studies report discrepant findings and no consensus exists for the clinical use of tDCS. The present work aims (i) to determine the most effective stimulation parameters to optimize antidepressant-like effect of tDCS in the forced-swim test in naïve mice and to evaluate the ability of tDCS to reverse depressive-like behaviors in different mouse models of depression, and (ii) to identify some of the mechanisms of action of tDCS to enhance our knowledge on this therapeutic strategy, and thus its clinical effects. We reported that tDCS induced long-lasting antidepressant-like effect, which varied as a function of stimulation settings including number, duration, intensity and polarity of stimulation. Interestingly, the present study also demonstrated that tDCS reduced depressive-like behaviors in different mouse models of depression…

Advisors/Committee Members: Haffen, Emmanuel (thesis director), Monnin, Julie (thesis director), Etievant, Adeline (thesis director).

Subjects/Keywords: Tdcs; Dépression; Modèle animal; Inflammation; Tdcs; Depression; Animial model; Inflammation; 612.8; WL 141.5.T7

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Peanlikhit, T. (2018). La stimulation transcrânienne par courant continu (tDCS) dans la dépression : ses effets comportementaux et les modifications physiologiques qui les sous-tendent chez l’animal : Transcranial Direct Current Stimulation (tDCS) in depression : Its behavioral effects and the underlying physiological modifications in animal. (Doctoral Dissertation). Bourgogne Franche-Comté. Retrieved from http://www.theses.fr/2018UBFCE020

Chicago Manual of Style (16^th Edition):

Peanlikhit, Tanat. “La stimulation transcrânienne par courant continu (tDCS) dans la dépression : ses effets comportementaux et les modifications physiologiques qui les sous-tendent chez l’animal : Transcranial Direct Current Stimulation (tDCS) in depression : Its behavioral effects and the underlying physiological modifications in animal.” 2018. Doctoral Dissertation, Bourgogne Franche-Comté. Accessed January 24, 2021. http://www.theses.fr/2018UBFCE020.

MLA Handbook (7^th Edition):

Peanlikhit, Tanat. “La stimulation transcrânienne par courant continu (tDCS) dans la dépression : ses effets comportementaux et les modifications physiologiques qui les sous-tendent chez l’animal : Transcranial Direct Current Stimulation (tDCS) in depression : Its behavioral effects and the underlying physiological modifications in animal.” 2018. Web. 24 Jan 2021.

Vancouver:

Peanlikhit T. La stimulation transcrânienne par courant continu (tDCS) dans la dépression : ses effets comportementaux et les modifications physiologiques qui les sous-tendent chez l’animal : Transcranial Direct Current Stimulation (tDCS) in depression : Its behavioral effects and the underlying physiological modifications in animal. [Internet] [Doctoral dissertation]. Bourgogne Franche-Comté; 2018. [cited 2021 Jan 24]. Available from: http://www.theses.fr/2018UBFCE020.

Council of Science Editors:

Peanlikhit T. La stimulation transcrânienne par courant continu (tDCS) dans la dépression : ses effets comportementaux et les modifications physiologiques qui les sous-tendent chez l’animal : Transcranial Direct Current Stimulation (tDCS) in depression : Its behavioral effects and the underlying physiological modifications in animal. [Doctoral Dissertation]. Bourgogne Franche-Comté; 2018. Available from: http://www.theses.fr/2018UBFCE020

20. Saruco, Elodie. Imagerie motrice et amputation du membre inférieur : Motor Imagery and Lower-Limb Amputation.

Degree: Docteur es, Neurosciences, 2017, Lyon

URL: http://www.theses.fr/2017LYSE1237

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L'imagerie motrice, ou représentation interne d'un mouvement, est une technique d'entraînement mental ayant la particularité d'impacter la plasticité cérébrale activité-dépendante. La pertinence de son intégration… (more)

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L'imagerie motrice, ou représentation interne d'un mouvement, est une technique d'entraînement mental ayant la particularité d'impacter la plasticité cérébrale activité-dépendante. La pertinence de son intégration au sein des programmes de rééducation fonctionnelle a été validée par de nombreuses études expérimentales, tout particulièrement pour les personnes victimes d'un accident vasculaire cérébral ou d'une lésion de la moelle épinière. Les résultats obtenus par ce travail de thèse élargissent l'éventail des populations pouvant bénéficier de cette approche en validant la faisabilité et en précisant les conditions optimales de l'intégration de l'imagerie motrice dans le cadre de la rééducation de personnes amputées du membre inférieur. Nous rapportons également des résultats préliminaires prometteurs quant à ses effets sur le recouvrement de leurs capacités locomotrices. Les données montrent que le travail en imagerie motrice devrait être spécifique aux mouvements fonctionnels bilatéraux et que, sous réserve d'une prochaine validation auprès de cette population, l'imagerie motrice de tâches posturales ainsi que l'utilisation conjointe de la stimulation transcrânienne à courant continu, devraient permettre de maximiser son pouvoir d'action sur le recouvrement de la locomotion de personnes amputées du membre inférieur

Motor imagery, which refers to the internal representation of a movement, has the potential to impact activity-dependent plasticity. The relevance of motor imagery, as a technique allowing substantial motor performance gains and motor recovery in the field of rehabilitation, has been validated by numerous experimental studies in stroke patients and persons suffering from spinal cord injury. By highlighting the possibility of integrating motor imagery within the framework of lower-limb amputees’ rehabilitation programs, and revealing promising preliminary data regarding locomotion recovery, the results of this thesis broaden the range of people which might benefit from this technique. Data further suggest that motor imagery should specifically focus on functional and bilateral tasks, and that concomitant use of transcranial direct current stimulation should contribute to potentiate the impact of motor imagery on locomotion recovery of lower-limb amputees

Advisors/Committee Members: Guillot, Aymeric (thesis director), Saimpont, Arnaud (thesis director).

Subjects/Keywords: Imagerie motrice; Amputation du membre inférieur; Locomotion; TDCS; Motor imagery; Lower-limb amputation; Locomotion; TDCS; 612.7

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Saruco, E. (2017). Imagerie motrice et amputation du membre inférieur : Motor Imagery and Lower-Limb Amputation. (Doctoral Dissertation). Lyon. Retrieved from http://www.theses.fr/2017LYSE1237

Chicago Manual of Style (16^th Edition):

Saruco, Elodie. “Imagerie motrice et amputation du membre inférieur : Motor Imagery and Lower-Limb Amputation.” 2017. Doctoral Dissertation, Lyon. Accessed January 24, 2021. http://www.theses.fr/2017LYSE1237.

MLA Handbook (7^th Edition):

Saruco, Elodie. “Imagerie motrice et amputation du membre inférieur : Motor Imagery and Lower-Limb Amputation.” 2017. Web. 24 Jan 2021.

Vancouver:

Saruco E. Imagerie motrice et amputation du membre inférieur : Motor Imagery and Lower-Limb Amputation. [Internet] [Doctoral dissertation]. Lyon; 2017. [cited 2021 Jan 24]. Available from: http://www.theses.fr/2017LYSE1237.

Council of Science Editors:

Saruco E. Imagerie motrice et amputation du membre inférieur : Motor Imagery and Lower-Limb Amputation. [Doctoral Dissertation]. Lyon; 2017. Available from: http://www.theses.fr/2017LYSE1237

21. Denoyer, Yves. Stimulation électrique transcrânienne multisite dans l'épilepsie pharmaco-résistante : High-resolution transcranial direct current stimulation in drug-resistant epilepsy.

Degree: Docteur es, Automatique, productique et robotique, 2019, Rennes 1

URL: http://www.theses.fr/2019REN1S110

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La stimulation cérébrale transcrânienne à courant continu (tDCS) est une technique de neuromodulation qui a connu un essor récent en neurologie clinique et en neuropsychologie.… (more)

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La stimulation cérébrale transcrânienne à courant continu (tDCS) est une technique de neuromodulation qui a connu un essor récent en neurologie clinique et en neuropsychologie. La stimulation cathodale a un effet inhibiteur sur le cortex cérébral, qui pourrait avoir une action thérapeutique dans l’épilepsie focale, avec des effets rémanents parfois durables. Les mécanismes neurophysiologiques en restent mal connus. La première partie de ce travail est une étude clinique pilote visant à tester un nouveau matériel de tDCS à haute résolution dans l’épilepsie focale pharmacorésistante. 5 patients ont eu une session unique de 30 minutes de tDCS cathodale individuellement paramétrée selon un algorithme d’optimisation du champ électrique. L’EEG a été enregistré avant, immédiatement après, à h8 et h24 de la stimulation. Les crises épileptiques ont été dénombrées sur une semaine avant et après. 1 patient a eu une amélioration clinique et sur certains paramètres EEG, de manière reproductible. 3 patients n’ont pas eu de modification de leur épilepsie. Un patient a rapporté une aggravation clinique, avec possiblement un corrélat électrophysiologique. Ces résultats sont discutés, en essayant de comprendre leur hétérogénéité et les pistes à envisager pour les améliorer. La deuxième partie décrit la conception d’un modèle computationnel visant à expliquer certains effets de la tDCS sur le cortex à échelle microscopique. Un modèle de colonne corticale intégrant 10.000 neurones (cellules principales glutamatergiques et 3 types d’interneurones GABAergiques) connectés par 5.106 synapses, est construit en respectant une topographie et un fonctionnement synaptique simplifié qui intègre des règles de plasticité homéostatique. On étudie le potentiel membranaire moyen des cellules principales, censé représenter le potentiel de champ local. On simule un champ électrique externe représentant la tDCS, qui influence la genèse des potentiels d’action et la neurotransmission présynaptique. En conditions d’hyperexcitabilité simulant un cortex épileptique, un champ externe cathodal peut diminuer la fréquence des paroxysmes. Une plasticité homéostatique appliquée simultanément peut induire des effets rémanents, suggérant que ces derniers reposent partiellement sur les effets immédiats couplés à la plasticité.

Transcranial direct current stimulation (tDCS) is a neuromodulation technique that has recently flourished in clinical neurology and neuropsychology. Cathodal stimulation has an inhibitory action on the cerebral cortex, which could be therapeutic in focal epilepsy, with lasting effects. However, the neurophysiological mechanisms remain poorly known. The first part of this work is a pilot clinical study to test a new high-resolution tDCS device in drug-resistant focal epilepsy. 5 patients had a single 30-minute cathodal tDCS session, individually parameterized according to an electric field optimization algorithm. The EEG was recorded before, immediately after, at h8 and h24 after stimulation. Epileptic seizures were counted over a week…

Advisors/Committee Members: Wendling, Fabrice (thesis director), Benquet, Pascal (thesis director).

Subjects/Keywords: Epilepsie; Neuromodulation; TDCS; Cortex cérébral; Modélisation des systèmes biologiques; Epilepsy; Neuromodulation; TDCS; Cerebral cortex; Modeling of biological systems

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Denoyer, Y. (2019). Stimulation électrique transcrânienne multisite dans l'épilepsie pharmaco-résistante : High-resolution transcranial direct current stimulation in drug-resistant epilepsy. (Doctoral Dissertation). Rennes 1. Retrieved from http://www.theses.fr/2019REN1S110

Chicago Manual of Style (16^th Edition):

Denoyer, Yves. “Stimulation électrique transcrânienne multisite dans l'épilepsie pharmaco-résistante : High-resolution transcranial direct current stimulation in drug-resistant epilepsy.” 2019. Doctoral Dissertation, Rennes 1. Accessed January 24, 2021. http://www.theses.fr/2019REN1S110.

MLA Handbook (7^th Edition):

Denoyer, Yves. “Stimulation électrique transcrânienne multisite dans l'épilepsie pharmaco-résistante : High-resolution transcranial direct current stimulation in drug-resistant epilepsy.” 2019. Web. 24 Jan 2021.

Vancouver:

Denoyer Y. Stimulation électrique transcrânienne multisite dans l'épilepsie pharmaco-résistante : High-resolution transcranial direct current stimulation in drug-resistant epilepsy. [Internet] [Doctoral dissertation]. Rennes 1; 2019. [cited 2021 Jan 24]. Available from: http://www.theses.fr/2019REN1S110.

Council of Science Editors:

Denoyer Y. Stimulation électrique transcrânienne multisite dans l'épilepsie pharmaco-résistante : High-resolution transcranial direct current stimulation in drug-resistant epilepsy. [Doctoral Dissertation]. Rennes 1; 2019. Available from: http://www.theses.fr/2019REN1S110

Kyoto University / 京都大学

22. Ashizuka, Aoi. Functional relevance of the precuneus in verbal politeness : 言語的ポライトネスにおける楔前部の機能意義.

Degree: 博士(医学), 2015, Kyoto University / 京都大学

URL: http://hdl.handle.net/2433/199196 ; http://dx.doi.org/10.14989/doctor.k18887

新制・課程博士

甲第18887号

医博第3998号

Subjects/Keywords: Politeness; Precuneus; fMRI; tDCS

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ashizuka, A. (2015). Functional relevance of the precuneus in verbal politeness : 言語的ポライトネスにおける楔前部の機能意義. (Thesis). Kyoto University / 京都大学. Retrieved from http://hdl.handle.net/2433/199196 ; http://dx.doi.org/10.14989/doctor.k18887

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ashizuka, Aoi. “Functional relevance of the precuneus in verbal politeness : 言語的ポライトネスにおける楔前部の機能意義.” 2015. Thesis, Kyoto University / 京都大学. Accessed January 24, 2021. http://hdl.handle.net/2433/199196 ; http://dx.doi.org/10.14989/doctor.k18887.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ashizuka, Aoi. “Functional relevance of the precuneus in verbal politeness : 言語的ポライトネスにおける楔前部の機能意義.” 2015. Web. 24 Jan 2021.

Vancouver:

Ashizuka A. Functional relevance of the precuneus in verbal politeness : 言語的ポライトネスにおける楔前部の機能意義. [Internet] [Thesis]. Kyoto University / 京都大学; 2015. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/2433/199196 ; http://dx.doi.org/10.14989/doctor.k18887.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ashizuka A. Functional relevance of the precuneus in verbal politeness : 言語的ポライトネスにおける楔前部の機能意義. [Thesis]. Kyoto University / 京都大学; 2015. Available from: http://hdl.handle.net/2433/199196 ; http://dx.doi.org/10.14989/doctor.k18887

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Leiden University

23. Endhoven, Bart. The efficacy of Transcranial Direct Current Stimulation (tDCS) as a treatment for auditory hallucinations: A randomized sham controlled trial.

Degree: 2016, Leiden University

URL: http://hdl.handle.net/1887/39205

Subjects/Keywords: tDCS treatment; auditory hallucinations

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Endhoven, B. (2016). The efficacy of Transcranial Direct Current Stimulation (tDCS) as a treatment for auditory hallucinations: A randomized sham controlled trial. (Masters Thesis). Leiden University. Retrieved from http://hdl.handle.net/1887/39205

Chicago Manual of Style (16^th Edition):

Endhoven, Bart. “The efficacy of Transcranial Direct Current Stimulation (tDCS) as a treatment for auditory hallucinations: A randomized sham controlled trial.” 2016. Masters Thesis, Leiden University. Accessed January 24, 2021. http://hdl.handle.net/1887/39205.

MLA Handbook (7^th Edition):

Endhoven, Bart. “The efficacy of Transcranial Direct Current Stimulation (tDCS) as a treatment for auditory hallucinations: A randomized sham controlled trial.” 2016. Web. 24 Jan 2021.

Vancouver:

Endhoven B. The efficacy of Transcranial Direct Current Stimulation (tDCS) as a treatment for auditory hallucinations: A randomized sham controlled trial. [Internet] [Masters thesis]. Leiden University; 2016. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/1887/39205.

Council of Science Editors:

Endhoven B. The efficacy of Transcranial Direct Current Stimulation (tDCS) as a treatment for auditory hallucinations: A randomized sham controlled trial. [Masters Thesis]. Leiden University; 2016. Available from: http://hdl.handle.net/1887/39205

University of Illinois – Chicago

24. Sriraman, Aishwarya. Reliability of tDCS Induced Corticomotor Excitability in Lower Limb Motor Cortex of Healthy Individuals.

Degree: 2015, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/19406

► Noninvasive brain stimulation techniques, such as transcranial direct current stimulation (tDCS), have emerged as a promising tool to enhance motor function by modulating corticomotor excitability.… (more)

Subjects/Keywords: tDCS; reliability; lower limb motor cortex; motor skill; neuroplasticity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sriraman, A. (2015). Reliability of tDCS Induced Corticomotor Excitability in Lower Limb Motor Cortex of Healthy Individuals. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/19406

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sriraman, Aishwarya. “Reliability of tDCS Induced Corticomotor Excitability in Lower Limb Motor Cortex of Healthy Individuals.” 2015. Thesis, University of Illinois – Chicago. Accessed January 24, 2021. http://hdl.handle.net/10027/19406.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sriraman, Aishwarya. “Reliability of tDCS Induced Corticomotor Excitability in Lower Limb Motor Cortex of Healthy Individuals.” 2015. Web. 24 Jan 2021.

Vancouver:

Sriraman A. Reliability of tDCS Induced Corticomotor Excitability in Lower Limb Motor Cortex of Healthy Individuals. [Internet] [Thesis]. University of Illinois – Chicago; 2015. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/10027/19406.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sriraman A. Reliability of tDCS Induced Corticomotor Excitability in Lower Limb Motor Cortex of Healthy Individuals. [Thesis]. University of Illinois – Chicago; 2015. Available from: http://hdl.handle.net/10027/19406

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

25. Sandars, Margaret. Understanding the Nature and Treatment of Anomia in Chronic Post-Stroke Aphasia.

Degree: 2018, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:315634

► The typical treatment for chronic post-stroke anomia is behavioural speech and language therapy. However, such therapy is not always effective or efficient. Previous research indicates… (more)

▼ The typical treatment for chronic post-stroke anomia is behavioural speech and language therapy. However, such therapy is not always effective or efficient. Previous research indicates that transcranial Direct Current Stimulation (tDCS) can enhance the effects of behavioural speech and language therapy, yet these findings have been limited by the highly varied protocols used across studies. A comprehensive, longitudinal intervention programme was subsequently devised to investigate the effects of systematically varying the laterality and polarity of stimulation on a range of language measures. Outcomes following active perilesional and contralesional stimulation were directly compared with those obtained following ipsilateral sham stimulation. Chapter 3 demonstrated that combining computer-based repetition therapy with 1mA anodal tDCS delivered to the left frontal lobe of a participant with chronic Broca's aphasia led to significantly greater improvements in treated noun naming accuracy than those achieved following therapy alone. This result is in line with neuroimaging findings linking increased activation in left frontal perilesional regions to post-stroke language recovery. Chapter 4 extended this work by repeating the same tDCS-plus-therapy schedule with a further three participants with differing lesion profiles and aphasia diagnoses. Although significant treatment gains were noted, there were no additional benefits of any form of active stimulation for two of these individuals, and the outcomes for the remaining patient were inconclusive. As such, the results of Chapter 4 clearly highlight between-participant variability in response to tDCS. Chapter 5 documented, for the first time, the extent and nature of response inconsistency in confrontation picture naming across multiple trials. When presented with a large corpus of object images twice, 15 participants named an average of almost 26% of items correctly on one occasion and incorrectly on the other. A wide range of demographic, behavioural and psycholinguistic factors provided an incomplete account of the observed patterns in naming response inconsistency. Finally, Chapter 6 comprised a behavioural case series designed to determine the relative importance of visual speech articulation in computer-based repetition therapy. Five of the six participants responded positively to at least one type of therapy, and all showed the greatest therapeutic gains when therapy included articulatory cues. Links between aphasia classifications and patterns of therapeutic response were complemented by exploratory structural neuroimaging findings indicating that different neural regions may mediate the effects of each type of therapy. The designs of the empirical studies in the current thesis facilitate in-depth analysis of therapy outcomes on a patient-by-patient basis. The findings have considerable clinical applicability, and indicate interesting potential directions for future research. Advisors/Committee Members: CLOUTMAN, LAUREN LL, Woollams, Anna, Cloutman, Lauren.

Subjects/Keywords: aphasia; anomia; transcranial Direct Current Stimulation; tDCS; stroke; therapy

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APA (6^th Edition):

Sandars, M. (2018). Understanding the Nature and Treatment of Anomia in Chronic Post-Stroke Aphasia. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:315634

Chicago Manual of Style (16^th Edition):

Sandars, Margaret. “Understanding the Nature and Treatment of Anomia in Chronic Post-Stroke Aphasia.” 2018. Doctoral Dissertation, University of Manchester. Accessed January 24, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:315634.

MLA Handbook (7^th Edition):

Sandars, Margaret. “Understanding the Nature and Treatment of Anomia in Chronic Post-Stroke Aphasia.” 2018. Web. 24 Jan 2021.

Vancouver:

Sandars M. Understanding the Nature and Treatment of Anomia in Chronic Post-Stroke Aphasia. [Internet] [Doctoral dissertation]. University of Manchester; 2018. [cited 2021 Jan 24]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:315634.

Council of Science Editors:

Sandars M. Understanding the Nature and Treatment of Anomia in Chronic Post-Stroke Aphasia. [Doctoral Dissertation]. University of Manchester; 2018. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:315634

University of Ottawa

26. Kami, Aline Tiemi. Investigating Motor Preparatory and Initiation Processes in Parkinson’s Disease Using Transcranial Direct Current Stimulation and Startle .

Degree: 2020, University of Ottawa

URL: http://hdl.handle.net/10393/40247

► Parkinson’s Disease is a slowly progressing neurodegenerative process that is a result of a basal ganglia (BG) dysfunction caused by the death of dopaminergic neurons… (more)

▼ Parkinson’s Disease is a slowly progressing neurodegenerative process that is a result of a basal ganglia (BG) dysfunction caused by the death of dopaminergic neurons in the substantia nigra which could lead to difficulties in planning, initiating, and executing movement. One technique for studying movement preparation and initiation is the use of a Startling Acoustic Stimulus (SAS), which has been associated with changes in the movement processing in PD. Transcranial direct current stimulation (tDCS) has been used to modulate cortical excitability and neuroplasticity in humans, providing a potential method to improve motor performance in PD. As such, the purpose of the experiment was to investigate the potential benefits of tDCS applied over the primary motor area (MI) and supplementary motor area (SMA) associated with SAS paradigm to improve preparation and initiation of the movement in individuals with PD. Eleven individuals with PD completed two simple reaction time (RT) tasks, a button-press task (BU) and an elbow extension task (EX) and underwent to a bradykinesia assessment, before and after application of tDCS. Three tDCS testing sessions (Anodal-MI; Anodal-SMA; Sham) were carried-out separated by 48 hours to ensure a complete washout of any residual effects. Results from this experiment reinforce previous findings indicating that following a SAS, participants were able to elicit the prepared motor response in significantly shorter latencies, and movement time and time to peak displacement were improved as well. Additionally, the results also suggest that the premotor RT can be facilitated by tDCS applied over SMA in non-SAS condition. This is indicative that any potential increase in cortical excitability induced by tDCS was able to promote changes in the neural tissue which might have influenced the activation of structures and pathways involved in preparation and initiation – in particular a basal ganglia-thalamo-cortical pathway. We suggest that stimulation of the SMA with anodal-tDCS using simple RT task as strategy can be applied to improve preparatory and initiation processes in individuals with PD.

Subjects/Keywords: Parkinson’s disease; Supplementary motor area; tDCS; Movement preparation

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APA (6^th Edition):

Kami, A. T. (2020). Investigating Motor Preparatory and Initiation Processes in Parkinson’s Disease Using Transcranial Direct Current Stimulation and Startle . (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/40247

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kami, Aline Tiemi. “Investigating Motor Preparatory and Initiation Processes in Parkinson’s Disease Using Transcranial Direct Current Stimulation and Startle .” 2020. Thesis, University of Ottawa. Accessed January 24, 2021. http://hdl.handle.net/10393/40247.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kami, Aline Tiemi. “Investigating Motor Preparatory and Initiation Processes in Parkinson’s Disease Using Transcranial Direct Current Stimulation and Startle .” 2020. Web. 24 Jan 2021.

Vancouver:

Kami AT. Investigating Motor Preparatory and Initiation Processes in Parkinson’s Disease Using Transcranial Direct Current Stimulation and Startle . [Internet] [Thesis]. University of Ottawa; 2020. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/10393/40247.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kami AT. Investigating Motor Preparatory and Initiation Processes in Parkinson’s Disease Using Transcranial Direct Current Stimulation and Startle . [Thesis]. University of Ottawa; 2020. Available from: http://hdl.handle.net/10393/40247

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Newcastle

27. Marquez, Jodie. Transcranial direct current stimulation: a potential modality for stroke rehabilitation.

Degree: PhD, 2018, University of Newcastle

URL: http://hdl.handle.net/1959.13/1383654

►

Research Doctorate - Doctor of Philosophy (PhD)

Transcranial Direct Current Stimulation (tDCS) is a form of non-invasive brain stimulation which has been investigated in a… (more)

▼

Research Doctorate - Doctor of Philosophy (PhD)

Transcranial Direct Current Stimulation (tDCS) is a form of non-invasive brain stimulation which has been investigated in a broad range of neuropsychiatric conditions and as a method to modulate cognitive performance in healthy individuals. It is generally accepted that the main mechanism by which tDCS modulates brain function is via a neural membrane polarization shift which can, in turn, lead to diverse changes in single neuron, synaptic and network activity (Peterchev, Wagner et al. 2012). However, the direction of polarization shift is sensitive to the stimulation dose, the state of brain activity at the time of stimulation and individual anatomy (Bikson and Rahman 2013). This results in a large inter individual variability to the neurophysiological and behavioural response to tDCs. Given the simplicity of tDCS and the complexity of brain function, we sought to unveil some of the physiological mechanisms underpinning the effects of tDCS in order to better our understanding of the variability in response to tDCS and to allow us to predict those most likely to respond. Ultimately our objective was to direct the translation of the research evidence into therapeutic applications of tDCS for stroke patients. The aim of this research was to determine the potential application of tDCS in the stroke population. At the commencement of this PhD research project, keen interest in the use of tDCS as a potential therapeutic tool in neuromotor conditions, such as stroke, was emerging. As tDCS is portable, relatively inexpensive, free from major adverse effects, and easily applied concurrently with other interventions, it is ideally suited for use in stroke rehabilitation therapy. The goal of tDCS in stroke is to increase cortical excitability of the lesioned hemisphere and/or reduce excitability on the non-lesioned hemisphere to restore interhemispheric balance (Mordillo-Mateos, Turpin-Fenoll et al. 2012). The vast majority of literature investigating tDCS has been conducted in young, healthy subject. As stroke patients are typically more senior and have age related changes in cortical structure, function and excitability, we began our investigation into the functional and physiological effects of tDCS in a healthy, aged population. We found that the hemispheres responded differently to tDCS and the response appeared to be task specific, but it was not mediated by age. However, a subsequent multimodal imaging study did not support these findings and failed to reveal a difference when tDCS was applied to the dominant or non-dominant hemisphere but showed that the effects were diffuse and determined by the type of stimulation. In a systematic review of the stroke literature we synthesised the evidence from 15 studies and confirmed the safety and acceptability of this modality in the stroke population. We concluded that tDCS may be effective in enhancing motor performance, atleast in the short term. Those most likely to benefit were patients with chronic stroke and/or mild to…

Advisors/Committee Members: University of Newcastle. Faculty of Health & Medicine, School of Medicine and Public Health.

Subjects/Keywords: tDCS; brain stimulation; stroke; rehabilitation; upper limb; aging

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Marquez, J. (2018). Transcranial direct current stimulation: a potential modality for stroke rehabilitation. (Doctoral Dissertation). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/1383654

Chicago Manual of Style (16^th Edition):

Marquez, Jodie. “Transcranial direct current stimulation: a potential modality for stroke rehabilitation.” 2018. Doctoral Dissertation, University of Newcastle. Accessed January 24, 2021. http://hdl.handle.net/1959.13/1383654.

MLA Handbook (7^th Edition):

Marquez, Jodie. “Transcranial direct current stimulation: a potential modality for stroke rehabilitation.” 2018. Web. 24 Jan 2021.

Vancouver:

Marquez J. Transcranial direct current stimulation: a potential modality for stroke rehabilitation. [Internet] [Doctoral dissertation]. University of Newcastle; 2018. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/1959.13/1383654.

Council of Science Editors:

Marquez J. Transcranial direct current stimulation: a potential modality for stroke rehabilitation. [Doctoral Dissertation]. University of Newcastle; 2018. Available from: http://hdl.handle.net/1959.13/1383654

Northeastern University

28. Güler, Şeyhmus. Brain stimulus pattern optimization using scalp and cortical electrode arrays.

Degree: PhD, Department of Electrical and Computer Engineering, 2016, Northeastern University

URL: http://hdl.handle.net/2047/D20237548

► Electrical stimulation of human brain to modulate on-going brain activity has become a topic of great interest in both clinical and research communities. The standard… (more)

▼ Electrical stimulation of human brain to modulate on-going brain activity has become a topic of great interest in both clinical and research communities. The standard approach to deliver electrical currents to the brain uses two electrodes: one stimulation electrode and one return electrode with interchangeable roles over time. In order to more precisely direct the injected current to a particular brain region of interest (ROI), there has been increasing interest in the use of arrays of many small electrodes, known as "dense electrode array". Two brain stimulation modalities that often make use of dense arrays are transcranial direct current stimulation (tDCS) and electrocorticography (ECoG) stimulation. Dense array tDCS makes use of scalp electrode arrays to deliver electical currents noninvasively while ECoG electrode grids are placed directly on the cortical surface for improved spatial specificity. Although the overall clinical objective may differ in dense array tDCS and ECoG stimulation, they both can benefit from systematic optimization methods to determine the optimal electrode stimulus patterns.; In this thesis, we develop optimization methods that increase the precision of targeting with dense array tDCS and ECoG stimulation. We first formulate and solve an optimization problem to determine the best stimulus patterns for scalp electrodes with fixed positioning for dense array tDCS. Specifically, the proposed optimization method maximizes the current along a particular direction in the ROI while satisfying three safety constraints for subject safety. The three constraints constrain the total injected current, individual electrode currents, and the current power in the brain outside the ROI. This leads to a small-size convex optimization problem, which we are able to solve very effectively using a general convex optimization solver (CVX) to get unique and global stimulus patterns as solution. We present simulation results for this method on a realistic head model and contrast it with two other leading methods in this field, using both focal and spatially extended cortical ROIs. Optimized stimulus patterns using this approach assume availability of individually controlled current sources for each electrode, which may be impractical in many settings. We use a branch and bound (BB) algorithm to approximate fully optimized stimulus patterns with only a few current sources. We conduct a simulation study to optimize stimulus pattern of an array consisting of 247 scalp electrodes and a semi-invasive mouth electrode, to assess the effect of the mouth electrode in targeting hippocampi. Finally, for ECoG stimulation, we adopt the same approach but with additional constraints on the local current density magnitude in response to the additional safety concerns raised with ECoG arrays. These additional constraints that prevent any local current density hot-spot across the entire brain create a computational barrier, which we overcome by taking a two step approach. The first step removes a subset of redundant constraints…

Subjects/Keywords: dense array; electrocorticography; focality; optimization; tDCS; transcranial current stimulation

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APA (6^th Edition):

Güler, �. (2016). Brain stimulus pattern optimization using scalp and cortical electrode arrays. (Doctoral Dissertation). Northeastern University. Retrieved from http://hdl.handle.net/2047/D20237548

Chicago Manual of Style (16^th Edition):

Güler, Şeyhmus. “Brain stimulus pattern optimization using scalp and cortical electrode arrays.” 2016. Doctoral Dissertation, Northeastern University. Accessed January 24, 2021. http://hdl.handle.net/2047/D20237548.

MLA Handbook (7^th Edition):

Güler, Şeyhmus. “Brain stimulus pattern optimization using scalp and cortical electrode arrays.” 2016. Web. 24 Jan 2021.

Vancouver:

Güler �. Brain stimulus pattern optimization using scalp and cortical electrode arrays. [Internet] [Doctoral dissertation]. Northeastern University; 2016. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/2047/D20237548.

Council of Science Editors:

Güler �. Brain stimulus pattern optimization using scalp and cortical electrode arrays. [Doctoral Dissertation]. Northeastern University; 2016. Available from: http://hdl.handle.net/2047/D20237548

Boston University

29. Nguyen, Victoria. The effects of transcranial direct current stimulation on dual-task walking in Parkinson's disease.

Degree: MS, Medical Sciences, 2016, Boston University

URL: http://hdl.handle.net/2144/17010

► BACKGROUND: Parkinson’s disease (PD) is a common debilitating disorder that largely effects the aging population. It is associated with a loss of dopamine-producing brain cells,… (more)

▼ BACKGROUND: Parkinson’s disease (PD) is a common debilitating disorder that largely effects the aging population. It is associated with a loss of dopamine-producing brain cells, which leads to abnormal brain activity and ultimately, a loss of locomotor control. Transcranial direct current stimulation (tDCS) is a technology that effectively modulates brain excitability by sending low electric current through the scalp. It has been demonstrated to improve working memory, intelligence, learning ability, as well as relieving symptoms of depression, Alzheimer’s and schizophrenia (Kekic, Boysen, Campbell, & Schmidt, 2015; Khedr et al., 2014; Manor et al., 2015). tDCS may thus serve as an effective therapeutic strategy for this vulnerable PD population. OBJECTIVE: The primary purpose of this study was to examine the acute effects of single sessions of tDCS targeting different brain networks on locomotor control metrics and other outcomes in patients with PD. DESIGN: A pilot, double-blinded, sham-controlled study. METHODS: A total of 15 older adults between the ages of 40-85 with a physician diagnosis of PD will be recruited. Participants are screened with questionnaires to determine eligibility. If eligible, participants will undergo a dual task assessment and a freezing of gait (FOG) provoking protocol prior to, as well as immediately after, a 20-minute session of tDCS. The acute effects of each stimulation session will be observed. There will be three different stimulation conditions that each target different areas of the brain: the motor cortex (M1), the motor cortex and the dorsolateral prefrontal cortex (DLPFC), and a sham (i.e., control) condition. Multiple aspects of locomotion (i.e., FOG, gait speed, stride time variability, percent of each walking stride spent with both feet on the ground) and cognition are assessed. RESULTS: This study began enrolling participants on March 3rd, 2016. To date, one participant has been enrolled and completed baseline testing as well as all three tDCS visits. This 42-year-old participant was diagnosed with PD two years ago and symptoms are mild. No side effects were observed during tDCS and the participant was unable to decipher between the M1 and the sham stimulation, but was able to tell the difference between sessions when receiving multi-focal stimulation. DISCUSSION: In this case study, tDCS was well tolerated by the patient and double-blinding procedures were effective. Thus, while tDCS did not induce significant improvements in gait or cognition in this relatively high functioning patient, the developed study protocol and tDCS intervention are highly feasible in the PD population.

Subjects/Keywords: Gerontology; Freezing of gait; Parkinson's disease; tDCS; Dual-tasking; Stimulation

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APA (6^th Edition):

Nguyen, V. (2016). The effects of transcranial direct current stimulation on dual-task walking in Parkinson's disease. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/17010

Chicago Manual of Style (16^th Edition):

Nguyen, Victoria. “The effects of transcranial direct current stimulation on dual-task walking in Parkinson's disease.” 2016. Masters Thesis, Boston University. Accessed January 24, 2021. http://hdl.handle.net/2144/17010.

MLA Handbook (7^th Edition):

Nguyen, Victoria. “The effects of transcranial direct current stimulation on dual-task walking in Parkinson's disease.” 2016. Web. 24 Jan 2021.

Vancouver:

Nguyen V. The effects of transcranial direct current stimulation on dual-task walking in Parkinson's disease. [Internet] [Masters thesis]. Boston University; 2016. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/2144/17010.

Council of Science Editors:

Nguyen V. The effects of transcranial direct current stimulation on dual-task walking in Parkinson's disease. [Masters Thesis]. Boston University; 2016. Available from: http://hdl.handle.net/2144/17010

University of Exeter

30. Carpenter, Kathryn Louise. An examination of the neural correlates and behavioural phenomena of category learning.

Degree: PhD, 2017, University of Exeter

URL: http://hdl.handle.net/10871/28194

► This thesis investigates the neurobiological pathways that underpin learning of visual categories, and the behaviour associated with these neural systems. The work contains two strands.… (more)

▼ This thesis investigates the neurobiological pathways that underpin learning of visual categories, and the behaviour associated with these neural systems. The work contains two strands. The first assesses the neural and behavioural predictions of the COmpetition between Verbal and Implicit Systems (COVIS) account of category learning. The second aims to examine the brain regions implicated in the prototype effect after transcranial Direct Current Stimulation (tDCS) to the left dorsolateral prefrontal cortex (DLPFC). COVIS predicts there are separate explicit and implicit category learning systems. According to COVIS, the explicit system optimally learns rule-based (RB) categories and relies upon the frontal lobes for working memory (WM) and executive functioning processes, and the medial temporal lobes (MTL) to store decision boundaries. In contrast, the implicit system employs the basal ganglia to procedurally learn information-integration (II) categories through stimulus-response associations. Experiment 1 found little evidence of separable implicit or explicit systems in an fMRI study that investigated category decision making processes during RB and II category learning using conditions matched in difficulty, category separation and number of relevant stimulus dimensions. Contrary to the predictions of COVIS, the MTL was more active during the II condition compared to the RB condition, an area that should be more engaged by the explicit system. There was also extensive neural activation overlap found between RB and II learning. Experiments 2 and 3 aimed to generalise these neural findings to activation during feedback processing in RB and II conditions. Experiment 2 was a behavioural study which showed that adding a feedback delay necessary for fMRI data analysis did not differentially impact RB or II learning. Experiment 3, including this feedback delay, found the same neural pattern of results as Experiment 1 offering further support that the MTL is more engaged in II learning than RB learning. There was also again considerable overlap in the regions involved in the two tasks. Taken together, Experiments 1 to 3 found no evidence for the neurally dissociable category learning systems predicted by COVIS. Experiments 4, 5 and 6 investigated the behavioural dissociation reported by Smith et al. (2014) that deferring feedback to the end of a six trial block selectively impairs II learning compared to a unidimensional RB condition. Experiment 4 replicated this result. However, when equating the number of dimensions relevant for RB and II learning in Experiment 5, both conditions were hindered by deferring feedback, with Experiment 6 confirming that conjunctive RB learning was impaired by deferred feedback compared to immediate feedback. I concluded that the dissociation reported by Smith et al. is attributed to the use of a unidimensional category as a comparison for II performance, and that when the number of relevant stimulus dimensions between conditions are controlled there is little evidence for the separable…

Subjects/Keywords: 153.1; Category learning; Prototype effect; COVIS; tDCS; MRI; Behaviour

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APA (6^th Edition):

Carpenter, K. L. (2017). An examination of the neural correlates and behavioural phenomena of category learning. (Doctoral Dissertation). University of Exeter. Retrieved from http://hdl.handle.net/10871/28194

Chicago Manual of Style (16^th Edition):

Carpenter, Kathryn Louise. “An examination of the neural correlates and behavioural phenomena of category learning.” 2017. Doctoral Dissertation, University of Exeter. Accessed January 24, 2021. http://hdl.handle.net/10871/28194.

MLA Handbook (7^th Edition):

Carpenter, Kathryn Louise. “An examination of the neural correlates and behavioural phenomena of category learning.” 2017. Web. 24 Jan 2021.

Vancouver:

Carpenter KL. An examination of the neural correlates and behavioural phenomena of category learning. [Internet] [Doctoral dissertation]. University of Exeter; 2017. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/10871/28194.

Council of Science Editors:

Carpenter KL. An examination of the neural correlates and behavioural phenomena of category learning. [Doctoral Dissertation]. University of Exeter; 2017. Available from: http://hdl.handle.net/10871/28194

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Open Access Theses and Dissertations