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You searched for subject:(superficial dorsal horn). Showing records 1 – 2 of 2 total matches.

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Queensland University of Technology

1. Gerke, Michelle Barbara. Characterisation of the expression of cell-surface carbohydrates by primary sensory neurones and their applications in the study of pain.

Degree: 2000, Queensland University of Technology

Subjects/Keywords: Pain; Nociceptors; Lectins; pain; nociceptor; lectin; glycoconjugate; Bandeiraea simplicifolia I-isolectin B4; Ulex europaeus agglutinin; electrophysiology; sciatic nerve; dorsal root ganglion; spinal cord; superficial dorsal horn; dorsal funiculus; chronic constriction injury; modality; electron microscopy; fluoresence microscopy; confocal microscopy; thesis; doctoral

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Gerke, M. B. (2000). Characterisation of the expression of cell-surface carbohydrates by primary sensory neurones and their applications in the study of pain. (Thesis). Queensland University of Technology. Retrieved from http://eprints.qut.edu.au/37060/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Gerke, Michelle Barbara. “Characterisation of the expression of cell-surface carbohydrates by primary sensory neurones and their applications in the study of pain.” 2000. Thesis, Queensland University of Technology. Accessed June 25, 2019. http://eprints.qut.edu.au/37060/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Gerke, Michelle Barbara. “Characterisation of the expression of cell-surface carbohydrates by primary sensory neurones and their applications in the study of pain.” 2000. Web. 25 Jun 2019.

Vancouver:

Gerke MB. Characterisation of the expression of cell-surface carbohydrates by primary sensory neurones and their applications in the study of pain. [Internet] [Thesis]. Queensland University of Technology; 2000. [cited 2019 Jun 25]. Available from: http://eprints.qut.edu.au/37060/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gerke MB. Characterisation of the expression of cell-surface carbohydrates by primary sensory neurones and their applications in the study of pain. [Thesis]. Queensland University of Technology; 2000. Available from: http://eprints.qut.edu.au/37060/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of Sydney

2. Wrigley, Paul John. Cold thermal processing in the spinal cord .

Degree: 2006, University of Sydney

Two recently identified transient receptor potential (TRP) channels, TRPM8 and TRPA1, have been proposed to play an important role in mammalian cool and cold peripheral sensory transduction. When expressed in cell-lines the cloned TRPM8 and TRPA1 receptors have distinct pharmacological and temperature response characteristics. Although these receptors are also transported to the central terminals of primary afferents, little is known about their centrally mediated actions. In this thesis, I use an in vitro electrophysiological approach to investigate the dorsal horn processing of cool afferent modalities and the role of TRP ion channels. The results of this thesis provide further information on thermal processing, indicate direction for further research and suggest possible therapeutic targets for the management of abnormal cold sensory processing. Initial experiments demonstrate that the cooling agents and known TRPM8 and TRPA1 agonists, menthol and icilin, inhibit primary afferent evoked excitatory postsynaptic currents (EPSCs) in rat spinal cord dorsal horn neurons. In addition, temperature reduction, menthol and icilin increase the frequency of miniature EPSCs without affecting amplitude distribution or kinetics. Little or no direct postsynaptic effect on dorsal horn neurons, GABAergic or glycinergic transmission was found. In combination, these observations demonstrate that temperature reduction, menthol and icilin act presynaptically to increase the probability of glutamate release from primary afferent fibres. Further examination of the changes in glutamatergic synaptic transmission induced by temperature reduction, menthol and icilin reveals a subset of neurons sensitive to innocuous cool (< 29 °C) and low concentrations of icilin (3-10 ┬ÁM) which closely match the temperature activation and pharmacological profile of TRPM8. In addition, the majority of lamina I and II neurons displayed characteristics partly consistent with TRPA1-activation, including a concentration-dependent response to icilin and blockade by ruthenium red. The present experiments did not allow thermal characterisation of these TRPA1-like responses. Together these observations indicate that the effects of menthol and icilin on glutamatergic synaptic transmission in the superficial dorsal horn are mediated by TRPM8 and possibly by TRPA1. Examination of the anatomical location of neurons activated by temperature reduction, menthol, icilin and capsaicin allowed the central termination pattern of thermoreceptive primary afferent fibres with specific TRP-like response characteristics to be determined. TRPM8-like presynaptic activation was confined to a subpopulation of neurons located in lamina I and outer lamina II, while the majority of neurons throughout laminae I and II received inputs sensitive to menthol, high concentrations of icilin and capsaicin. These findings suggest that innocuous cool sensation projects to a specific subpopulation of superficial dorsal horn neurons unlike other modalities (mediated by TRPV1, possibly…

Subjects/Keywords: cold; cool; central thermal processing; spinal cord; superficial dorsal horn; synaptic transmission; whole-cell patch clamping; transient receptor potential receptors; TRPM8; TRPA1; TRPV1; menthol; icilin; capsaicin; opioid agonists; delta-opioid agonists

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Wrigley, P. J. (2006). Cold thermal processing in the spinal cord . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/1619

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Wrigley, Paul John. “Cold thermal processing in the spinal cord .” 2006. Thesis, University of Sydney. Accessed June 25, 2019. http://hdl.handle.net/2123/1619.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Wrigley, Paul John. “Cold thermal processing in the spinal cord .” 2006. Web. 25 Jun 2019.

Vancouver:

Wrigley PJ. Cold thermal processing in the spinal cord . [Internet] [Thesis]. University of Sydney; 2006. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2123/1619.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wrigley PJ. Cold thermal processing in the spinal cord . [Thesis]. University of Sydney; 2006. Available from: http://hdl.handle.net/2123/1619

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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