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You searched for subject:(spared nerve injury). Showing records 1 – 3 of 3 total matches.

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University of Georgia

1. Gutierrez, Tannia. Self-administration of a cannabinoid CB2 agonist in an animal model of neuropathic pain.

Degree: 2014, University of Georgia

We evaluated the impact of neuropathic pain on the propensity of rats to self-administer the cannabinoid CB2 agonist AM1241. CB2 is prevalent outside the central nervous system (CNS) and is induced in the CNS by traumatic nerve injury. A unilateral spared nerve injury was performed to induce neuropathic pain. Control rats were subjected to a sham surgery and naive animals were intact. Animals were surgically implanted with an indwelling jugular catheter to allow intravenous drug self-administration. Mechanical withdrawal thresholds were evaluated in the left and right paws before and after surgical procedures and before and after each drug self-administration session. AM1241 self-administration, but not vehicle, increased mechanical withdrawal thresholds in the left (injured) paw in neuropathic rats. Changes in mechanical withdrawal thresholds were absent following AM1241 self-administration in naive and sham-operated groups. Self-administration, as defined by preferential responding on the active but not the inactive lever, was observed in neuropathic and sham-operated groups receiving AM1241 (day 1). No difference was observed in the number of active and inactive lever presses in rats self-administering vehicle. The CB2 antagonist SR144528 blocked the AM1241-induced suppression of nerve injury-induced tactile allodynia and attenuated active lever responding. The CB1 antagonist SR141716 induced hypersensitivity in the right (intact) paw in neuropathic and naive groups self-administering vehicle or AM1241. SR141716 induced hypersensitivity in paw withdrawal thresholds in the left (intact) paw in naive groups self-administering vehicle. SR141716 attenuated active and inactive lever presses in naive and neuropathic groups self-administering vehicle. Morphine self-administration elevated paw withdrawal thresholds in neuropathic rats, but not in naive or sham-operated groups. By day 2, naive and neuropathic groups self-administering morphine responded preferentially on the active and not the inactive lever. The maximally self-administered dose of AM1241 failed to induce motor deficits in naive or neuropathic groups in the rotarod test. Our data demonstrate that self-administration of AM1241 suppresses nerve injury-induced tactile allodynia. The observation that naive animals self-administered morphine but not AM1241 is consistent with the hypothesis that activation of CB2 is not inherently reinforcing and raises the possibility that CB2 agonists may represent a class of analgesics with low abuse liability.

Subjects/Keywords: Spared Nerve Injury; Neuropathic Pain; Intravenous; Self-administration

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Gutierrez, T. (2014). Self-administration of a cannabinoid CB2 agonist in an animal model of neuropathic pain. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/23851

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Gutierrez, Tannia. “Self-administration of a cannabinoid CB2 agonist in an animal model of neuropathic pain.” 2014. Thesis, University of Georgia. Accessed March 07, 2021. http://hdl.handle.net/10724/23851.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Gutierrez, Tannia. “Self-administration of a cannabinoid CB2 agonist in an animal model of neuropathic pain.” 2014. Web. 07 Mar 2021.

Vancouver:

Gutierrez T. Self-administration of a cannabinoid CB2 agonist in an animal model of neuropathic pain. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/10724/23851.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gutierrez T. Self-administration of a cannabinoid CB2 agonist in an animal model of neuropathic pain. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/23851

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Dalhousie University

2. Liu, Jean. Further Studies in Adenosinergic and Monoaminergic Mechanisms of Analgesia by Amitriptyline.

Degree: MS, Department of Pharmacology with Neuroscience, 2012, Dalhousie University

In this thesis, rodent models of chronic pain were used to explore analgesic mechanisms that may potentially be engaged in spinal and peripheral compartments by systemically-administered amitriptyline, a tricyclic antidepressant. The first project (Chapter 2) identified the roles of spinal adenosine A1 and serotonin 5-HT7 receptors, as well as of peripheral adenosine A1 receptors, in the acute antinociceptive effects of amitriptyline in mice. The second project (Chapter 3) examined the potential utility of amitriptyline as a preventive analgesic against persistent post-surgical pain, and involved perioperative administration of amitriptyline after peripheral nerve injury in rats. Changes in post-injury behavioural outcomes, as well as spinal noradrenergic sprouting, were assessed. Overall, spinal serotonergic pathways linked to adenosine A1 receptors, as well as peripheral adenosine A1 receptors, appear to be important in antinociception by amitriptyline. Preventive analgesia by this drug does not appear to result from anatomical changes in spinal noradrenergic pathways. Advisors/Committee Members: Kazue Semba (external-examiner), Eileen Denovan-Wright (graduate-coordinator), Jason McDougall (thesis-reader), Jana Sawynok (thesis-supervisor), Received (ethics-approval), Not Applicable (manuscripts), Not Applicable (copyright-release).

Subjects/Keywords: amitriptyline; persistent post-surgical pain; adenosine A1 receptor; serotonin 5-HT7 receptor; formalin test; antinociception; spared nerve injury; preventive analgesia; antidepressants; pain

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Liu, J. (2012). Further Studies in Adenosinergic and Monoaminergic Mechanisms of Analgesia by Amitriptyline. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/15329

Chicago Manual of Style (16th Edition):

Liu, Jean. “Further Studies in Adenosinergic and Monoaminergic Mechanisms of Analgesia by Amitriptyline.” 2012. Masters Thesis, Dalhousie University. Accessed March 07, 2021. http://hdl.handle.net/10222/15329.

MLA Handbook (7th Edition):

Liu, Jean. “Further Studies in Adenosinergic and Monoaminergic Mechanisms of Analgesia by Amitriptyline.” 2012. Web. 07 Mar 2021.

Vancouver:

Liu J. Further Studies in Adenosinergic and Monoaminergic Mechanisms of Analgesia by Amitriptyline. [Internet] [Masters thesis]. Dalhousie University; 2012. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/10222/15329.

Council of Science Editors:

Liu J. Further Studies in Adenosinergic and Monoaminergic Mechanisms of Analgesia by Amitriptyline. [Masters Thesis]. Dalhousie University; 2012. Available from: http://hdl.handle.net/10222/15329


Université de Montréal

3. Parent-Vachon, Madeleine. Effets de l'exercice sur le développement foetal chez la souris lors de douleur neuropathique chez la femelle gestante.

Degree: 2019, Université de Montréal

Subjects/Keywords: Douleur neuropathique; Enrichissement de l'environnement; Peptides de la douleur; Exercice; Souris; Neuropathic pain; Gestation; Environmental enrichment; Spared nerve injury; Exercise; Pain peptides; Mice; Biology - Veterinary Science / Biologie - Science vétérinaire (UMI : 0778)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Parent-Vachon, M. (2019). Effets de l'exercice sur le développement foetal chez la souris lors de douleur neuropathique chez la femelle gestante. (Thesis). Université de Montréal. Retrieved from http://hdl.handle.net/1866/22622

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Parent-Vachon, Madeleine. “Effets de l'exercice sur le développement foetal chez la souris lors de douleur neuropathique chez la femelle gestante.” 2019. Thesis, Université de Montréal. Accessed March 07, 2021. http://hdl.handle.net/1866/22622.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Parent-Vachon, Madeleine. “Effets de l'exercice sur le développement foetal chez la souris lors de douleur neuropathique chez la femelle gestante.” 2019. Web. 07 Mar 2021.

Vancouver:

Parent-Vachon M. Effets de l'exercice sur le développement foetal chez la souris lors de douleur neuropathique chez la femelle gestante. [Internet] [Thesis]. Université de Montréal; 2019. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/1866/22622.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Parent-Vachon M. Effets de l'exercice sur le développement foetal chez la souris lors de douleur neuropathique chez la femelle gestante. [Thesis]. Université de Montréal; 2019. Available from: http://hdl.handle.net/1866/22622

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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