Open Access Theses and Dissertations

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University of Toronto

1. Xu, Songyi. N-cadherin Regulation of Vascular Smooth Muscle Cells; the Role of DDR1 and Rho GTPases.

Degree: PhD, 2020, University of Toronto

URL: http://hdl.handle.net/1807/101328 

N-cadherin mediates cell-cell contacts in vascular smooth muscle cells (VSMCs) and regulates VSMC behaviours. Discoidin domain receptor 1 (DDR1) is a collagen binding receptor also implicated in these processes. Previous studies showed that both N-cadherin and DDR1 are upregulated after vascular injury, but it is not known whether the two molecules are associated. The ability to establish proper N-cadherin junctions is important in regulating VSMC behaviour. In my studies, I found that N-cadherin could associate with DDR1, and that this association was increased during VSMC migration and wound closure. I found that N-cadherin was reduced in lipid rafts and mislocalized from cell-cell junctions in the absence of DDR1. Disruption of lipid rafts by cholesterol oxidase or methyl-β-cyclodextrin removed N-cadherin from lipid rafts of DDR1+/+ VSMCs and disrupted N-cadherin contacts, and these effects were reversed by cholesterol rescue that restored lipid rafts. Knockdown of DDR1 by siRNA resulted in mislocalized N-cadherin contacts from cell junctions, and transfection of DDR1-/- VSMCs with full-length DDR1 rescued the formation of N-cadherin junctions. The mislocalization of N-cadherin contacts in DDR1-/- VSMCs was also accompanied by disruption of the actin cytoskeleton. N-cadherin contacts in VSMCs undergo constant remodeling, especially during disease processes. Calcium switch to disrupt and restore contacts did not affect N-cadherin triton solubility in DDR1+/+ and DDR1-/- VSMCs or the association between N-cadherin and DDR1. While collagen stimulation of DDR1 increased the association between N-cadherin and DDR1 in cells with mature, well-established cell contacts, it did not affect N-cadherin localization, its triton solubility, or the association between N-cadherin and DDR1 during contact disruption, restoration, and wound closure. Rho GTPases are master regulators of the cytoskeleton and can mediate cytoskeletal processes downstream of cell-cell contacts. Using calcium switch and plating on either IgG or N-cadherin-Fc coated surfaces, active Rho GTPase pull-down assays showed a consistent decrease in Cdc42 and RhoA activity after N-cadherin contact establishment in DDR1+/+ SMCs. Overall, these data reveal that N-cadherin cell-cell contacts in VSMCs can be regulated through interaction with DDR1 and localization in lipid rafts, and that the establishment of N-cadherin contacts can suppress Rho GTPase activity. Advisors/Committee Members: Bendeck, Michelle, Laboratory Medicine and Pathobiology.

Subjects/Keywords: Cell-cell interaction; DDR1; N-cadherin; Rho GTPases; Vascular smooth muscle cells; 0307

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Xu, S. (2020). N-cadherin Regulation of Vascular Smooth Muscle Cells; the Role of DDR1 and Rho GTPases. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/101328

Chicago Manual of Style (16th Edition):

Xu, Songyi. “N-cadherin Regulation of Vascular Smooth Muscle Cells; the Role of DDR1 and Rho GTPases.” 2020. Doctoral Dissertation, University of Toronto. Accessed January 19, 2021. http://hdl.handle.net/1807/101328.

MLA Handbook (7th Edition):

Xu, Songyi. “N-cadherin Regulation of Vascular Smooth Muscle Cells; the Role of DDR1 and Rho GTPases.” 2020. Web. 19 Jan 2021.

Vancouver:

Xu S. N-cadherin Regulation of Vascular Smooth Muscle Cells; the Role of DDR1 and Rho GTPases. [Internet] [Doctoral dissertation]. University of Toronto; 2020. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1807/101328.

Council of Science Editors:

Xu S. N-cadherin Regulation of Vascular Smooth Muscle Cells; the Role of DDR1 and Rho GTPases. [Doctoral Dissertation]. University of Toronto; 2020. Available from: http://hdl.handle.net/1807/101328

2. Desormeaux, Kevin. Temporal models of motions and forces for Human-Robot Interactive manipulation : Modèles temporels du mouvement et des forces pour la manipulation Interactive Homme-Robot.

Degree: Docteur es, Robotique, Informatique, 2019, Université Toulouse III – Paul Sabatier

URL: http://www.theses.fr/2019TOU30221 

L'intérêt pour la robotique a débuté dans les années 70 et depuis les robots n'ont cessé de remplacer les humains dans l'industrie. L'automatisation à outrance n'apporte cependant pas que des avantages, car elle nécessite des environnements parfaitement contrôlés et la reprogrammation d'une tâche est longue et fastidieuse. Le besoin accru d'adaptabilité et de ré-utilisabilité des systèmes d'assemblage force la robotique à se révolutionner en amenant notamment l'homme et le robot à interagir. Ce nouveau type de collaboration permet de combiner les forces respectives des humains et des robots. Cependant l'homme ne pourra être inclus en tant qu'agent actif dans ces nouveaux espaces de travail collaboratifs que si l'on dispose de robots sûrs, intuitifs et facilement reprogrammables. C'est à la lumière de ce constat qu'on peut deviner le rôle crucial de la génération de mouvement pour les robots de demain. Pour que les humains et les robots puissent collaborer, ces derniers doivent générer des mouvements sûrs afin de garantir la sécurité de l'homme tant physique que psychologique. Les trajectoires sont un excellent modèle pour la génération de mouvements adaptés aux robots collaboratifs, car elles offrent une description simple et précise de l'évolution du mouvement. Les trajectoires dîtes souples sont bien connues pour générer des mouvements sûrs et confortables pour l'homme. Dans cette thèse nous proposons un algorithme de génération de trajectoires temps-réel basé sur des séquences de segments de fonctions polynomiales de degré trois pour construire des trajectoires souples. Ces trajectoires sont construites à partir de conditions initiales et finales arbitraires, une condition nécessaire pour que les robots soient capables de réagir instantanément à des événements imprévus. L'approche basée sur un modèle à jerk-contraint offre des solutions orientées performance: les trajectoires sont optimales en temps sous contraintes de sécurité. Ces contraintes de sécurité sont des contraintes cinématiques qui dépendent de la tâche et du contexte et doivent être spécifiées. Pour guider le choix de ces contraintes, nous avons étudié le rôle de la cinématique dans la définition des propriétés ergonomiques du mouvement.[...]

It was in the 70s when the interest for robotics really emerged. It was barely half a century ago, and since then robots have been replacing humans in the industry. This robot-oriented solution doesn't come without drawbacks as full automation requires time-consuming programming as well as rigid environments. With the increased need for adaptability and reusability of assembly systems, robotics is undergoing major changes and see the emergence of a new type of collaboration between humans and robots. Human-Robot collaboration get the best of both world by combining the respective strengths of humans and robots. But, to include the human as an active agent in these new collaborative workspaces, safe and flexible robots are required. It is in this context that we can apprehend the crucial role of motion…

Advisors/Committee Members: Sidobre, Daniel (thesis director).

Subjects/Keywords: Génération de trajectoires en temps-réel; Interaction homme-robot; Contrôle réactif de trajectoires; Trajectoires souples; Ergonomie du mouvement; Online Trajectory Generation; Human-Robot Interaction; Reactive Trajectory Control; Smooth Trajectories; Motion Ergonomics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Desormeaux, K. (2019). Temporal models of motions and forces for Human-Robot Interactive manipulation : Modèles temporels du mouvement et des forces pour la manipulation Interactive Homme-Robot. (Doctoral Dissertation). Université Toulouse III – Paul Sabatier. Retrieved from http://www.theses.fr/2019TOU30221

Chicago Manual of Style (16th Edition):

Desormeaux, Kevin. “Temporal models of motions and forces for Human-Robot Interactive manipulation : Modèles temporels du mouvement et des forces pour la manipulation Interactive Homme-Robot.” 2019. Doctoral Dissertation, Université Toulouse III – Paul Sabatier. Accessed January 19, 2021. http://www.theses.fr/2019TOU30221.

MLA Handbook (7th Edition):

Desormeaux, Kevin. “Temporal models of motions and forces for Human-Robot Interactive manipulation : Modèles temporels du mouvement et des forces pour la manipulation Interactive Homme-Robot.” 2019. Web. 19 Jan 2021.

Vancouver:

Desormeaux K. Temporal models of motions and forces for Human-Robot Interactive manipulation : Modèles temporels du mouvement et des forces pour la manipulation Interactive Homme-Robot. [Internet] [Doctoral dissertation]. Université Toulouse III – Paul Sabatier; 2019. [cited 2021 Jan 19]. Available from: http://www.theses.fr/2019TOU30221.

Council of Science Editors:

Desormeaux K. Temporal models of motions and forces for Human-Robot Interactive manipulation : Modèles temporels du mouvement et des forces pour la manipulation Interactive Homme-Robot. [Doctoral Dissertation]. Université Toulouse III – Paul Sabatier; 2019. Available from: http://www.theses.fr/2019TOU30221


Brno University of Technology

3. Obr, Jakub. Pokročilá simulace a vizualizace kapaliny: Advanced Simulation and Vizualization of a Fluid.

Degree: 2019, Brno University of Technology

URL: http://hdl.handle.net/11012/54227 

This thesis concentrates on physically based simulation of fluids followed by its photorealistic visualization. It describes one form of Smooth Particle Hydrodynamics methods for viscoelastic fluid simulation and includes its extension for multiple interacting fluids. It also deals with SPH boundary problem and investigates its solution by fixed boundary particles. For visualization of fluids there is a method of Ray Tracing described in detail and it's extended with light absorption in transparent materials. In connection with this method there is also discussed a problem of infinite total reflections and some solution techniques are offered. To extract the surface of the fluid there is used a Marching cubes method and its discussed in terms of Ray Tracing. Advisors/Committee Members: Navrátil, Jan (advisor), Pečiva, Jan (referee).

Subjects/Keywords: simulace kapaliny; vizualizace kapaliny; Smooth Particles Hydrodynamics; SPH; neviditelné hraniční částice; interakce více kapalin; Ray Tracing; totální odrazy; vizualizace transparentního objektu; Marching Cubes; problém interpolace normál; liquid simulation; liquid visualization; Smooth Particles Hydrodynamics; SPH; fixed boundary particles; multiple fluids interaction; Ray Tracing; total reflections; transparent object visualization; Marching Cubes; normal interpolation problem

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Obr, J. (2019). Pokročilá simulace a vizualizace kapaliny: Advanced Simulation and Vizualization of a Fluid. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/54227

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Obr, Jakub. “Pokročilá simulace a vizualizace kapaliny: Advanced Simulation and Vizualization of a Fluid.” 2019. Thesis, Brno University of Technology. Accessed January 19, 2021. http://hdl.handle.net/11012/54227.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Obr, Jakub. “Pokročilá simulace a vizualizace kapaliny: Advanced Simulation and Vizualization of a Fluid.” 2019. Web. 19 Jan 2021.

Vancouver:

Obr J. Pokročilá simulace a vizualizace kapaliny: Advanced Simulation and Vizualization of a Fluid. [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/11012/54227.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Obr J. Pokročilá simulace a vizualizace kapaliny: Advanced Simulation and Vizualization of a Fluid. [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/54227

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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