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Universidade Federal de Santa Maria

1. Bibiana Mozzaquatro Gai. PERFIL FARMACOLÓGICO DO TIPO ANTIDEPRESSIVO DO COMPOSTO 3-(4-FLUOROFENILSELENIL)-2,5 DIFENILSELENOFENO: ENVOLVIMENTO DO SISTEMA SEROTONINÉRGICO.

Degree: 2011, Universidade Federal de Santa Maria

Depression is a serious, recurrent and incapacitating psychiatric condition with a heavy social burden. The pharmacological approach to this disorder employs therapy with antidepressant drugs, which have side effects and numerous limitations. In view of the promising pharmacological properties of containing-selenium molecules, this study evaluated the effect of 3-(4-fluorophenylselenyl)-2,5-diphenylselenophene (DPS) in the mouse forced swim test (FST) and tail suspension test (TST), two models predictive of depressant activity. Since serotonin (5-HT) plays an important role in the pathophysiology of depressive disorders, the involvement of serotonergic system and 5-HT receptors in the action caused by DPS was studied. The antidepressant-like action of combined treatment with subeffective doses of both DPS plus paroxetine, a selective serotonin reuptake inhibitor (SSRI) was investigated. Further, we verified the possible mechanism responsible for antidepressant-like action of DPS. The results showed that DPS (50 and 100 mg/kg, p.o.) significantly reduced the immobility time during the FST and TST, without accompanying changes in ambulation when assessed in the open-field test. The anti-immobility effect of DPS (50 mg/kg, i.g.) in the FST was prevented by pretreatment of mice with pCPA (p-chlorophenylalanine; an inhibitor of 5-HT synthesis, 100 mg/kg, i.p., once a day for 4 consecutive days,), WAY 100635 (N-[2- [4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexane carboxamide; 0.1 mg/kg, s.c., a selective 5-HT1A receptor antagonist), ritanserin (1 mg/kg, i.p., a 5-HT2 receptor antagonist) or ondansetron (1 mg/kg, i.p., a 5-HT3 receptor antagonist). Combined treatment with paroxetine and DPS reduced the immobility time in the FST. DPS at the dose of 50 mg/kg did not produce any change in the cerebral activity of monoamine oxidase subtypes (MAO-A or MAO-B). DPS at the dose of 50 mg/kg inhibited significantly 5-HT uptake in mouse brain synaptosomes. These results suggest that DPS produced an antidepressant-like action in the mouse FST and TST and this action seems most likely to be mediated through an interaction with serotonergic system, particularly by 5-HT reuptake inhibition.

A depressão é uma doença grave, recorrente e uma condição psiquiátrica incapacitante que gera pesados custos sociais. A abordagem farmacológica dessa desordem é feita por meio do emprego de antidepressivos, os quais apresentam efeitos adversos e numerosas limitações. Tendo em vista as promissoras propriedades farmacológicas das moléculas contendo selênio, este estudo avaliou o efeito do 3-(4-fluorofenilselenil)-2,5-difenilselenofeno (DPS) no teste do nado forçado (TNF) e no teste da suspensão da cauda (TSC) em camundongos, dois modelos preditivos de comportamento depressivo. Uma vez que a serotonina (5-HT) desempenha um importante papel na patofisiologia dos transtornos depressivos, o envolvimento do sistema serotoninérgico e dos receptores de 5-HT na ação desenvolvida pelo DPS foi estudado. A ação do tipo antidepressiva do…

Advisors/Committee Members: Margareth Linde Athayde, Cristina Wayne Nogueira, Marilise Escobar Burger.

Subjects/Keywords: selenofenos; compostos orgânicos de selênio; BIOQUIMICA; selenophene; organoselenium compounds; forced swimming test; tail suspension test; teste da suspensão da cauda; teste do nado forçado; sistema serotoninérgico; tipo antidepressivo; antidepressant-like; serotonergic system

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Gai, B. M. (2011). PERFIL FARMACOLÓGICO DO TIPO ANTIDEPRESSIVO DO COMPOSTO 3-(4-FLUOROFENILSELENIL)-2,5 DIFENILSELENOFENO: ENVOLVIMENTO DO SISTEMA SEROTONINÉRGICO. (Thesis). Universidade Federal de Santa Maria. Retrieved from http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=3849

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Gai, Bibiana Mozzaquatro. “PERFIL FARMACOLÓGICO DO TIPO ANTIDEPRESSIVO DO COMPOSTO 3-(4-FLUOROFENILSELENIL)-2,5 DIFENILSELENOFENO: ENVOLVIMENTO DO SISTEMA SEROTONINÉRGICO.” 2011. Thesis, Universidade Federal de Santa Maria. Accessed June 17, 2019. http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=3849.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Gai, Bibiana Mozzaquatro. “PERFIL FARMACOLÓGICO DO TIPO ANTIDEPRESSIVO DO COMPOSTO 3-(4-FLUOROFENILSELENIL)-2,5 DIFENILSELENOFENO: ENVOLVIMENTO DO SISTEMA SEROTONINÉRGICO.” 2011. Web. 17 Jun 2019.

Vancouver:

Gai BM. PERFIL FARMACOLÓGICO DO TIPO ANTIDEPRESSIVO DO COMPOSTO 3-(4-FLUOROFENILSELENIL)-2,5 DIFENILSELENOFENO: ENVOLVIMENTO DO SISTEMA SEROTONINÉRGICO. [Internet] [Thesis]. Universidade Federal de Santa Maria; 2011. [cited 2019 Jun 17]. Available from: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=3849.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gai BM. PERFIL FARMACOLÓGICO DO TIPO ANTIDEPRESSIVO DO COMPOSTO 3-(4-FLUOROFENILSELENIL)-2,5 DIFENILSELENOFENO: ENVOLVIMENTO DO SISTEMA SEROTONINÉRGICO. [Thesis]. Universidade Federal de Santa Maria; 2011. Available from: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=3849

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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