You searched for subject:(selectivity).
Showing records 1 – 30 of
671 total matches.
◁ [1] [2] [3] [4] [5] … [23] ▶
University of Illinois – Chicago
1.
Giri, Janhavi.
Study of Selectivity and Permeation in Voltage-Gated Ion Channels.
Degree: 2012, University of Illinois – Chicago
URL: http://hdl.handle.net/10027/8181 
► Ion channels are proteins with holes down their middle that regulate access to biological cells and are responsible for an enormous range of biological functions.…
(more)
▼ Ion channels are proteins with holes down their middle that regulate access to biological cells and are responsible for an enormous range of biological functions. A substantial fraction of the drugs used in clinical medicine are targeted directly or indirectly on channels. Ion
selectivity and permeation are based on simple laws of physics and chemistry. Ion channels are therefore ideal candidates for physical investigation. A reduced model generates the
selectivity of voltage-gated L-type calcium channel (crystal structure not known) under a wide range of ionic conditions using only two parameters with unchanging values. The reasons behind the success of this reduced model are investigated since chemical intuition suggests that more detailed models are needed. Monte Carlo simulations are performed investigating the role of flexibility of the side chains in the
selectivity of calcium channels under a wide range of ionic conditions. Results suggest that the exact location and mobility of oxygen ions have little effect on the
selectivity behavior of calcium channels. The first order determinant of
selectivity in calcium channels is the density of charge in the
selectivity filter. Flexibility seems a second order determinant. Single channel planar lipid bilayer experiments are performed to determine the
selectivity, permeation, and sialic acid specificity of a bacterial outer-membrane channel NanC of Escherichia Coli with a known crystal structure. Measurements show that NanC exhibits a large unit conductance varying with the applied voltage polarity, anion over cation
selectivity, and voltage-dependent gating. Unitary conductance of NanC decreases significantly in presence of the buffer HEPES. Alternate buffers are tested. Results suggest that the sialic acid specificity of NanC should be performed in low concentration salt solutions (250 mM) without pH buffers adjusted to neutral pH 7.0. Neu5Ac (a major sialic acid) is observed to change the gating and considerably increase the ionic conductance of NanC. The effect of Neu5Ac on the unitary current through NanC saturates at higher Neu5Ac concentrations. Interestingly, Neu5Ac reduces the ionic conductance of OmpF: frequent, long closures are seen. Therefore, in E.coli sialic acid translocation is specifically facilitated by NanC, and not by the general porin OmpF.
Advisors/Committee Members: Magin, Richard L (advisor).
Subjects/Keywords: ion channels; selectivity
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Giri, J. (2012). Study of Selectivity and Permeation in Voltage-Gated Ion Channels. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/8181
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Giri, Janhavi. “Study of Selectivity and Permeation in Voltage-Gated Ion Channels.” 2012. Thesis, University of Illinois – Chicago. Accessed June 24, 2019.
http://hdl.handle.net/10027/8181.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Giri, Janhavi. “Study of Selectivity and Permeation in Voltage-Gated Ion Channels.” 2012. Web. 24 Jun 2019.
Vancouver:
Giri J. Study of Selectivity and Permeation in Voltage-Gated Ion Channels. [Internet] [Thesis]. University of Illinois – Chicago; 2012. [cited 2019 Jun 24].
Available from: http://hdl.handle.net/10027/8181.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Giri J. Study of Selectivity and Permeation in Voltage-Gated Ion Channels. [Thesis]. University of Illinois – Chicago; 2012. Available from: http://hdl.handle.net/10027/8181
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
2.
Batista, Mariana Silveira [UNESP].
Diferenças no metabolismo das plantas que determinam resistência ao glyphosate em Conyza canadensis (L.) Cronquist.
Degree: 2016, Universidade Estadual Paulista
URL: http://hdl.handle.net/11449/144421
► A planta daninha está entre as espécies de maior importância nos campos de diversas culturas. Por se tratar de uma espécie que apresenta alto poder…
(more)
▼ A planta daninha está entre as espécies de maior importância nos campos de diversas culturas. Por se tratar de uma espécie que apresenta alto poder de produzir milhares de sementes que tem se adaptado ao uso de herbicidas, seu estudo se torna de grande importância para amenizar os danos causados às culturas. O trabalho foi desenvolvido com o objetivo de estudar as características morfofisiológicas da espécie Conyza canadensis (L.) Cronquist quanto à resistência ao herbicida do grupo químico das glicinas substituídas em plantas com histórico de resistência. O experimento foi instalado e conduzido durante o segundo semestre de 2014 em condição de campo na área da Universidade Federal do Mato Grosso do Sul – Campus Chapadão do Sul. O delineamento experimental foi blocos casualizados, com 4 repetições, os tratamentos em esquema fatorial 5x5, totalizando 25 tratamentos. O fator A correspondeu ao estádio de desenvolvimento: Tamanho I – plantas com 5 cm de altura; Tamanho II - 10 cm de altura; Tamanho III – 15 cm de altura; Tamanho IV – 20 cm de altura; Tamanho V – 25 cm de altura. O fator B foram as doses do glyphosate: Dose I (sem aplicação) - Testemunha; Dose II (1200 g i.a ha-1); Dose III (2400 g i.a ha-1); Dose IV (3600 g i.a ha-1) e Dose V (4800 g i.a ha-1). Foram realizadas análises de crescimento das plantas: altura de plantas e diâmetro do caule, aos 0, 14 e 28 dias após a aplicação dos tratamentos e uma avaliação de altura de plantas remanescentes ou rebrota realizada aos 100 dias após a aplicação. Para a análise de perdas de transpiração de folhas destacadas e hidratadas as plantas estavam em fase vegetativa e coletadas no terço-médio das plantas aos 0, 4 e 8 DAA. Os dados foram submetidos à análise de variância e as medias dos tratamentos comparadas pelo Teste de Scott Knott a 5% de probabilidade. Concluiu-se que tanto o tamanho das plantas como as doses do glyphosate influenciaram na altura de plantas, no diâmetro da haste e nas perdas de transpiração da espécie Conyza canadensis (L.) Cronquist. A porcentagem de redução da altura das plantas de tamanho menor foi maior conforme as doses de glyphosate aumentaram em todos os períodos das avaliações. Plantas de tamanho menor transpiram mais do que plantas de tamanho maior sem a aplicação de herbicida. Para as perdas de transpiração, as plantas de menor tamanho que receberam a aplicação do glyphosate em doses maiores, transpiraram menos. As plantas de tamanhos maiores transpiraram mais quando submetidas a doses medianas do glyphosate quando comparadas as doses maiores.
The weed is among the species of greatest importance in the fields of different cultures. Because it is a species that has a high power to produce thousands of seeds that have adapted to the use of herbicides, their study becomes very important to mitigate the damage to crops. The work was to study the morphological and physiological characteristics of species Conyza canadensis (L.) Cronquist for resistance to the herbicide chemical group of glycines substituted in plants with a history of…
Advisors/Committee Members: Carvalho, Fernando Tadeu de [UNESP], Universidade Estadual Paulista (UNESP).
Subjects/Keywords: Buva; Seletividade; Glyphosate; Horseweed; Selectivity
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Batista, M. S. [. (2016). Diferenças no metabolismo das plantas que determinam resistência ao glyphosate em Conyza canadensis (L.) Cronquist. (Thesis). Universidade Estadual Paulista. Retrieved from http://hdl.handle.net/11449/144421
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Batista, Mariana Silveira [UNESP]. “Diferenças no metabolismo das plantas que determinam resistência ao glyphosate em Conyza canadensis (L.) Cronquist.” 2016. Thesis, Universidade Estadual Paulista. Accessed June 24, 2019.
http://hdl.handle.net/11449/144421.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Batista, Mariana Silveira [UNESP]. “Diferenças no metabolismo das plantas que determinam resistência ao glyphosate em Conyza canadensis (L.) Cronquist.” 2016. Web. 24 Jun 2019.
Vancouver:
Batista MS[. Diferenças no metabolismo das plantas que determinam resistência ao glyphosate em Conyza canadensis (L.) Cronquist. [Internet] [Thesis]. Universidade Estadual Paulista; 2016. [cited 2019 Jun 24].
Available from: http://hdl.handle.net/11449/144421.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Batista MS[. Diferenças no metabolismo das plantas que determinam resistência ao glyphosate em Conyza canadensis (L.) Cronquist. [Thesis]. Universidade Estadual Paulista; 2016. Available from: http://hdl.handle.net/11449/144421
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Penn State University
3.
Noh, Young Dong.
Cation exchange properties of highly charged swelling micas
and titanosilicates.
Degree: PhD, Soil Science, 2010, Penn State University
URL: https://etda.libraries.psu.edu/catalog/11659
► The principal goal of this thesis work was to investigate cation exchange properties of highly charged swelling micas such as Na1Si3AlMg3O10F2 • xH2O (Na-2-mica), Na1.5Si2.5Al1.5Mg3O10F2…
(more)
▼ The principal goal of this thesis work was to
investigate cation exchange properties of highly charged swelling
micas such as Na1Si3AlMg3O10F2 • xH2O (Na-2-mica),
Na1.5Si2.5Al1.5Mg3O10F2 • xH2O (Na-3-mica), and Na2Si2Al2Mg3O10F2 •
xH2O (Na-4-mica) and titanosilicates such as sodium Engelhard
titanosilicate 4 (Na-ETS-4) and Na-titanosilicate. The three mica
ion exchangers were synthesized using a NaCl melt method and the
two Na titanosilicates were synthesized by hydrothermal treatment,
and characterized by X-ray diffraction and scanning electron
microscopy. In addition, 29Si and 27Al MASNMR spectroscopy was used
to understand layer charge properties of Na-micas and local
chemical binding environment of Si and Al. Cation exchange
isotherms and Kielland plots of the above five ion exchangers were
constructed in order to evaluate their selective cation exchange
properties for Sr2+ and Ba2+ and heavy metals such as Hg2+ and
Co2+. 2Na+→ Sr2+ exchange isotherms and Kielland plots
revealed that Na-2-mica, Na-ETS-4, and Na-titanosilicate showed
high selectivity for Sr2+. For the case of 2Na+→ Ba2+
exchange, Na-2-mica and Na-ETS-4 had high preference for Ba2+ over
Na+ with most of the equilibrium solutions used. Na-2-mica showed
higher selectivity for Sr2+ and Ba2+ than Na-3-mica and Na-4-mica
because of higher expansibility of Na-2-mica resulting in easier
accessibility to exchange sites in interlayer space than the other
two micas. This expansibility was limited by increasing
electrostatic attraction with the increase in intercalated divalent
cations. In the case of 2Na+ → Hg2+ exchange reaction,
Na-ETS-4 was found to have higher distribution coefficient (Kd)
value than any other ion exchangers tested. The Kielland plot for
Hg2+ showed that only Na-ETS-4 had selectivity for mercury (II)
with most of the exchange solutions used. 2Na+ →
Co2+exchange equilibria revealed that Na-2-mica and Na-ETS-4 had
high selectivity for cobalt ions over sodium ions at low Co
equivalent fraction in the solid phase. Two different (001) phases
of ~12 Å and ~14 Å were seen in the XRD patterns of the Na-micas
after 2Na+ → M2+ (M=Sr, Ba, Hg) exchange reactions with
different exchange solutions. This difference in the d001-value
suggested the presence of adsorbed divalent cations with different
hydration states in interlayer space after ion exchange reactions,
because of partial dehydration of intercalated cations by strong
electrostatic attraction between adsorbed cations and negatively
charged layers. Both the extent of divalent cations intercalated
and layer charge density affected the attractive electrostatic
force. As the uptake of adsorbed divalent cations in the solid
phase and the layer charge density increased, the electrostatic
attraction increased contributing to the increase in the extent of
the dehydration of cations intercalated. Unlike other cases, after
2Na+ → Co2+ exchange reaction, strong ~14 Å phase of
Na-2-mica was retained even at high Co2+ uptake, while ~12 Å phase
decreased as the amount of…
Subjects/Keywords: Mica; Titanosilicate; Ion exchange; Selectivity
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Noh, Y. D. (2010). Cation exchange properties of highly charged swelling micas
and titanosilicates. (Doctoral Dissertation). Penn State University. Retrieved from https://etda.libraries.psu.edu/catalog/11659
Chicago Manual of Style (16th Edition):
Noh, Young Dong. “Cation exchange properties of highly charged swelling micas
and titanosilicates.” 2010. Doctoral Dissertation, Penn State University. Accessed June 24, 2019.
https://etda.libraries.psu.edu/catalog/11659.
MLA Handbook (7th Edition):
Noh, Young Dong. “Cation exchange properties of highly charged swelling micas
and titanosilicates.” 2010. Web. 24 Jun 2019.
Vancouver:
Noh YD. Cation exchange properties of highly charged swelling micas
and titanosilicates. [Internet] [Doctoral dissertation]. Penn State University; 2010. [cited 2019 Jun 24].
Available from: https://etda.libraries.psu.edu/catalog/11659.
Council of Science Editors:
Noh YD. Cation exchange properties of highly charged swelling micas
and titanosilicates. [Doctoral Dissertation]. Penn State University; 2010. Available from: https://etda.libraries.psu.edu/catalog/11659
Montana State University
4.
Winward, Shelly Janine.
Attentional control and asymmetric priming.
Degree: College of Letters & Science, 2012, Montana State University
URL: https://scholarworks.montana.edu/xmlui/handle/1/2563
► The current research examined the relation between attentional control and strategies used during a lexical decision task. Participants completed a battery of three attentional control…
(more)
▼ The current research examined the relation between attentional control and strategies used during a lexical decision task. Participants completed a battery of three attentional control tasks and also performed a lexical decision task with symmetrical (e.g., brother, sister) or asymmetrical associated items presented in either the forward (e.g., stork, baby) or backward direction (e.g., baby, stork). Results indicated that individuals higher in attentional control showed greater priming for forward associates, but no priming difference in attentional control for backward associates. Further, equal priming occurred for symmetrical associates regardless of attentional control. Results thus illustrated that both high and low attentional control participants used a retrospective semantic matching strategy, while participants high in attentional control used an expectancy generation strategy. Implications are discussed in terms of existing strategies of attentional control and semantic priming.
Advisors/Committee Members: Chairperson, Graduate Committee: Keith A. Hutchison. (advisor), Collen F. Moore was incorrectly noted in thesis as the chairperson. (advisor).
Subjects/Keywords: Attention.; Selectivity (Psychology).; Priming (Psychology).
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Winward, S. J. (2012). Attentional control and asymmetric priming. (Thesis). Montana State University. Retrieved from https://scholarworks.montana.edu/xmlui/handle/1/2563
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Winward, Shelly Janine. “Attentional control and asymmetric priming.” 2012. Thesis, Montana State University. Accessed June 24, 2019.
https://scholarworks.montana.edu/xmlui/handle/1/2563.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Winward, Shelly Janine. “Attentional control and asymmetric priming.” 2012. Web. 24 Jun 2019.
Vancouver:
Winward SJ. Attentional control and asymmetric priming. [Internet] [Thesis]. Montana State University; 2012. [cited 2019 Jun 24].
Available from: https://scholarworks.montana.edu/xmlui/handle/1/2563.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Winward SJ. Attentional control and asymmetric priming. [Thesis]. Montana State University; 2012. Available from: https://scholarworks.montana.edu/xmlui/handle/1/2563
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
McGill University
5.
Djokovic-Ducic, Slobodanka.
Selective attention in adolescents with and without depressive symptoms.
Degree: MA, Department of Educational Psychology and Counselling., 1992, McGill University
URL: http://digitool.library.mcgill.ca/thesisfile61290.pdf
► Visual selective attention was examined in a sample of non-referred adolescents with high and low depressive symptomatology. Two standardized depression inventories (CDI, DEQ) were used…
(more)
▼ Visual selective attention was examined in a sample of non-referred adolescents with high and low depressive symptomatology. Two standardized depression inventories (CDI, DEQ) were used to classify the adolescents. The two groups were matched on age, sex and intelligence. The adolescents performed a forced-choice reaction time task designed to isolate several sources of interference in visual selective attention. Interference conditions varied with regard to number and type of distractors surrounding the target stimulus. Reaction times of the two groups were compared to identify differences in capacities and strategies utilized in filtering distracting information. Findings were examined with regard to the ability to select relevant information and ignore distracting information from the environment. Data analyses indicated that the reaction times of the adolescents who scored high on the depression scales were slower and more variable. In addition, facilitation occurred only with adolescents with low scores when the number of distractors exceeded visual capacities. The implications for understanding attentional capacities and strategies of adolescents with depressive symptoms are discussed.
Subjects/Keywords: Selectivity (Psychology)
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
Southern Illinois University
6.
Parks, Sherrie L.
The sound of music: The influence of evoked emotion on recognition memory for musical excerpts across the lifespan.
Degree: MA, Psychology, 2013, Southern Illinois University
URL: http://opensiuc.lib.siu.edu/theses/1143
► TITLE: THE SOUND OF MUSIC: THE INFLUENCE OF EVOKED EMOTION ON RECOGNITION MEMORY FOR MUSICAL EXCERPTS ACROSS THE LIFESPAN Socioemotional Selectivity Theory (Carstensen, 1999)…
(more)
▼ TITLE: THE SOUND OF MUSIC: THE INFLUENCE OF EVOKED EMOTION ON RECOGNITION MEMORY FOR MUSICAL EXCERPTS ACROSS THE LIFESPAN Socioemotional
Selectivity Theory (Carstensen, 1999) posits that as people age, they selectively focus on positive aspects of emotional stimuli as opposed to negative as a way of regulating emotions. Thus, older adults remember positive information better than negative. This hypothesis has been tested extensively with visual stimuli, but rarely with auditory stimuli. Findings from this study provide support in the auditory domain. In this study, 135 younger, middle-aged, and older adults heard consonant (pleasant) and dissonant (unpleasant) musical excerpts. Participants were randomly assigned to either a Study Only condition, in which they heard excerpts and studied them for later recognition, a Rate Only condition, in which they rated the excerpts and were tested later in a surprise recognition test, or a Rate and Study condition, in which they rated and studied the excerpts for later recognition. Results indicated that younger, middle-aged and older adults remembered consonant (pleasant) musical excerpts better than dissonant (unpleasant) musical excerpts overall and provide support for the hypotheses of the Socioemotional
Selectivity Theory.
Advisors/Committee Members: Clancy Dollinger, Stephanie.
Subjects/Keywords: music; Socioemotional Selectivity Theory
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Parks, S. L. (2013). The sound of music: The influence of evoked emotion on recognition memory for musical excerpts across the lifespan. (Masters Thesis). Southern Illinois University. Retrieved from http://opensiuc.lib.siu.edu/theses/1143
Chicago Manual of Style (16th Edition):
Parks, Sherrie L. “The sound of music: The influence of evoked emotion on recognition memory for musical excerpts across the lifespan.” 2013. Masters Thesis, Southern Illinois University. Accessed June 24, 2019.
http://opensiuc.lib.siu.edu/theses/1143.
MLA Handbook (7th Edition):
Parks, Sherrie L. “The sound of music: The influence of evoked emotion on recognition memory for musical excerpts across the lifespan.” 2013. Web. 24 Jun 2019.
Vancouver:
Parks SL. The sound of music: The influence of evoked emotion on recognition memory for musical excerpts across the lifespan. [Internet] [Masters thesis]. Southern Illinois University; 2013. [cited 2019 Jun 24].
Available from: http://opensiuc.lib.siu.edu/theses/1143.
Council of Science Editors:
Parks SL. The sound of music: The influence of evoked emotion on recognition memory for musical excerpts across the lifespan. [Masters Thesis]. Southern Illinois University; 2013. Available from: http://opensiuc.lib.siu.edu/theses/1143
KTH
7.
Saur, Ann-Kathrin.
Synthesis of α1,2- and α1,6, linked Dimannosides for Analysis of Protein Carbohydrate Interactions.
Degree: Chemical Science and Engineering (CHE), 2011, KTH
URL: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-49788
► The aim of the project was to synthesize α1,2-linked and α1,6-linked dimannosides linked through either an oxygen-atom or a sulphur-atom, and subsequently test the…
(more)
▼ The aim of the project was to synthesize α1,2-linked and α1,6-linked dimannosides linked through either an oxygen-atom or a sulphur-atom, and subsequently test the binding properties of the dimannosides to lectins with known specificity towards mannose-containing glycans. Thedimannosides were prepared by a glycosylation reaction using selectively protected monosaccharides containing a thiol or alcohol nucleophilic glycosyl acceptor and a series of different glycosyl donors. The synthetic routes to the different building blocks were designed to efficiently make use of common intermediate compounds to streamline the synthesis. The glycosyl acceptors used forthe synthesis of α1,2-linked as well as α1,6-linked dimannosides were synthesized in few steps and diversified only in the last steps of the synthesis. The glycosyl donors used in the study were synthesized from commercially available starting material in a straightforward and convenientsynthesis in 7 to 8 steps.
Subjects/Keywords: Synthesis; Carbohydrate; Selectivity; Protein; Analysis
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Saur, A. (2011). Synthesis of α1,2- and α1,6, linked Dimannosides for Analysis of Protein Carbohydrate Interactions. (Thesis). KTH. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-49788
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Saur, Ann-Kathrin. “Synthesis of α1,2- and α1,6, linked Dimannosides for Analysis of Protein Carbohydrate Interactions.” 2011. Thesis, KTH. Accessed June 24, 2019.
http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-49788.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Saur, Ann-Kathrin. “Synthesis of α1,2- and α1,6, linked Dimannosides for Analysis of Protein Carbohydrate Interactions.” 2011. Web. 24 Jun 2019.
Vancouver:
Saur A. Synthesis of α1,2- and α1,6, linked Dimannosides for Analysis of Protein Carbohydrate Interactions. [Internet] [Thesis]. KTH; 2011. [cited 2019 Jun 24].
Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-49788.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Saur A. Synthesis of α1,2- and α1,6, linked Dimannosides for Analysis of Protein Carbohydrate Interactions. [Thesis]. KTH; 2011. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-49788
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Université Catholique de Louvain
8.
Meyer, Nathalie.
Noble metal supported catalysts for lactose transformations in liquid phase.
Degree: 2014, Université Catholique de Louvain
URL: http://hdl.handle.net/2078.1/151944
► Carbohydrates are an important source of renewable materials which can be converted into high added-value products. Sugar transformations should ideally be carried out with recyclable…
(more)
▼ Carbohydrates are an important source of renewable materials which can be converted into high added-value products. Sugar transformations should ideally be carried out with recyclable catalysts, in water, with the highest possible selectivity in the desired product. The aim of the present work was to explore the microstructural properties of the heterogeneous catalysts needed to carry out selectively lactose oxidation into lactobionic acid and lactose hydrogenation into lactitol. The first part consisted in the investigation of the influence of two functionalized supports (γ-Al2O3 and Cxerogel) modified by metallic precursor grafting and activation on the catalytic performances in lactose oxidation. The oxygenated functions were shown to be detrimental. This was confirmed by the results obtained with an inert support, boron nitride, which can be a promising alternative support, ensuring high selectivity. Subsequently, the optimal range of particle size within Pd/h-BN catalysts for high activity and selectivity was investigated and the optimal size was determined between 3 and 15 nm with no particles inferior to 3 nm. The effectiveness of Au/h-BN was also evaluated and it exhibited spectacular performances. Au/h-BN was shown to be a good candidate for thermal regeneration for recycling. Lactose hydrogenation was finally investigated with Pd/h-BN and particles inferior to 3 nm were also undesired. The selectivity obtained in lactose hydrogenation seems to be greatly dependent on the mechanism of each possible side reaction.
(SC - Sciences) – UCL, 2014
Advisors/Committee Members: UCL - SST/IMCN/MOST - Molecules, Solids and Reactivity, UCL - Faculté des Sciences, Peeters, Daniel, Gaigneaux, Eric, Prati, Laura, Marchand, Jacqueline, Pirard, Jean-Paul, Hermans, Sophie, Devillers, Michel.
Subjects/Keywords: Lactose; Boron nitride; Palladium; Selectivity
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Meyer, N. (2014). Noble metal supported catalysts for lactose transformations in liquid phase. (Thesis). Université Catholique de Louvain. Retrieved from http://hdl.handle.net/2078.1/151944
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Meyer, Nathalie. “Noble metal supported catalysts for lactose transformations in liquid phase.” 2014. Thesis, Université Catholique de Louvain. Accessed June 24, 2019.
http://hdl.handle.net/2078.1/151944.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Meyer, Nathalie. “Noble metal supported catalysts for lactose transformations in liquid phase.” 2014. Web. 24 Jun 2019.
Vancouver:
Meyer N. Noble metal supported catalysts for lactose transformations in liquid phase. [Internet] [Thesis]. Université Catholique de Louvain; 2014. [cited 2019 Jun 24].
Available from: http://hdl.handle.net/2078.1/151944.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Meyer N. Noble metal supported catalysts for lactose transformations in liquid phase. [Thesis]. Université Catholique de Louvain; 2014. Available from: http://hdl.handle.net/2078.1/151944
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Minnesota
9.
Fan, Yang.
Electrostatically Enhanced Thioureas: Synthesis, Reactivity and Selectivity.
Degree: PhD, Chemistry, 2018, University of Minnesota
URL: http://hdl.handle.net/11299/200195
► Hydrogen bonding exhibits its importance in enzyme-catalyzed chemical transformations, naturally occurring three-dimensional architectures and molecular recognition. In recent years, synthetic chemists have successfully exploited hydrogen…
(more)
▼ Hydrogen bonding exhibits its importance in enzyme-catalyzed chemical transformations, naturally occurring three-dimensional architectures and molecular recognition. In recent years, synthetic chemists have successfully exploited hydrogen bonds and developed many enantioselective organocatalysts. As a result, small molecule hydrogen bond donors along with organometallic species and enzymes are now recognized as playing a major role in asymmetric synthesis. Thiourea derivatives are among the most common and widely-developed hydrogen bond catalysts. Impressive results in terms of both yields and enantioselectivities in asymmetric syntheses have been obtained. A key feature in their success is the ability of these compounds to simultaneously donate two hydrogen bonds to a substrate, despite their relatively weak acidity. This provides highly stereoconfined environments when chiral moieties are incorporated into the thiourea and has made them the subject of extensive research efforts. The work described in this thesis focuses on the development of a class of positively charged acidity-enhanced thiourea catalysts which make use of an alkylated pyridinium substituent and an appropriate non-coordinating counteranion to enhance their N‒H acidities and improve their catalytic activities by orders of magnitude in a variety of transformations. A series of these catalysts have been synthesized and their reactivities in both asymmetric and non-asymmetric transformations were explored. Simple and highly efficient synthetic schemes and excellent catalytic results have been discovered for these novel species.
Subjects/Keywords: catalysis; charge; reactivity; selectivity; thiourea
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Fan, Y. (2018). Electrostatically Enhanced Thioureas: Synthesis, Reactivity and Selectivity. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/200195
Chicago Manual of Style (16th Edition):
Fan, Yang. “Electrostatically Enhanced Thioureas: Synthesis, Reactivity and Selectivity.” 2018. Doctoral Dissertation, University of Minnesota. Accessed June 24, 2019.
http://hdl.handle.net/11299/200195.
MLA Handbook (7th Edition):
Fan, Yang. “Electrostatically Enhanced Thioureas: Synthesis, Reactivity and Selectivity.” 2018. Web. 24 Jun 2019.
Vancouver:
Fan Y. Electrostatically Enhanced Thioureas: Synthesis, Reactivity and Selectivity. [Internet] [Doctoral dissertation]. University of Minnesota; 2018. [cited 2019 Jun 24].
Available from: http://hdl.handle.net/11299/200195.
Council of Science Editors:
Fan Y. Electrostatically Enhanced Thioureas: Synthesis, Reactivity and Selectivity. [Doctoral Dissertation]. University of Minnesota; 2018. Available from: http://hdl.handle.net/11299/200195
University of New Mexico
10.
Peña-Esparza, Yajaira.
Attentional biases in dysphoric college students.
Degree: Psychology, 2011, University of New Mexico
URL: http://hdl.handle.net/1928/13106
► Cognitive biases in attention to emotional stimuli in an ethnically diverse sample of dysphoric and non-dysphoric college students were explored. The present study advanced the…
(more)
▼ Cognitive biases in attention to emotional stimuli in an ethnically diverse sample of dysphoric and non-dysphoric college students were explored. The present study advanced the literature by using ecologically valid eye movement data to assess attention. We hypothesized that dysphoric participants would orient their attention toward sad faces more quickly than the students without dysphoria. We also hypothesized that the dysphoric participants would sustain their attention on sad faces longer than the non-dysphoric participants. Caucasian and Latino undergraduate students were categorized into dysphoric (n = 30) and non-dysphoric (n = 36 based depressive symptom endorsement on the BDI-II (non-dysphoric: BDI-II ≤ 6, dysphoric: BDI-II \u2265 14). Eye movements were recorded with an eye-tracking device while the students viewed picture pairs of faces expressing sadness, happiness, or no emotion. The task consisted of 48 face pairs presented twice for a total of 96 trials. Consistent with the literature, dysphoric participants showed a negative bias in duration when sad faces were paired with neutral faces, but not when they were paired to happy faces. Dysphoric participants were not more likely to initially orient toward sad faces and when they did, latency was not significantly shorter to the sad face than to the other faces. Furthermore, depressive symptom scores were not associated with attentional biases for the dysphoric participants. Taken together, these findings are consistent with literature suggesting dysphoria and depression are characterized by elaboration of mood-congruent stimuli at later stages of information processing. However, the context in which the negative stimuli is presented is important. The elaboration of mood congruent stimuli was only evident in the context of a paired neutral stimuli; a paired positive stimuli did not support this elaboration effect. Additionally, symptom severity on the BDI-II did not influence the elaboration bias dysphoric participants exhibited. These findings have significant implications for the treatment and prevention of depression.
Advisors/Committee Members: Verney, Steven, Verney, Steven, Smith, Bruce, Ruthruff, Eric.
Subjects/Keywords: Selectivity (Psychology); Depression; Face perception.
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Peña-Esparza, Y. (2011). Attentional biases in dysphoric college students. (Masters Thesis). University of New Mexico. Retrieved from http://hdl.handle.net/1928/13106
Chicago Manual of Style (16th Edition):
Peña-Esparza, Yajaira. “Attentional biases in dysphoric college students.” 2011. Masters Thesis, University of New Mexico. Accessed June 24, 2019.
http://hdl.handle.net/1928/13106.
MLA Handbook (7th Edition):
Peña-Esparza, Yajaira. “Attentional biases in dysphoric college students.” 2011. Web. 24 Jun 2019.
Vancouver:
Peña-Esparza Y. Attentional biases in dysphoric college students. [Internet] [Masters thesis]. University of New Mexico; 2011. [cited 2019 Jun 24].
Available from: http://hdl.handle.net/1928/13106.
Council of Science Editors:
Peña-Esparza Y. Attentional biases in dysphoric college students. [Masters Thesis]. University of New Mexico; 2011. Available from: http://hdl.handle.net/1928/13106
University of New Mexico
11.
Jiang, Wei.
Development of novel fluorescent sensors for the detection of functional and bio-interesting small molecules and metal ions.
Degree: Department of Chemistry and Chemical Biology, 2010, University of New Mexico
URL: https://digitalrepository.unm.edu/chem_etds/4
► As one important kind of sensitive analytical technology, fluorescence method is widely applied in environmental science, materials, medicine pharmacy and nowadays much popularly in cellular…
(more)
▼ As one important kind of sensitive analytical technology, fluorescence method is widely applied in environmental science, materials, medicine pharmacy and nowadays much popularly in cellular biological science, which requires the development of diverse fluorescent sensors to meet various analytical and researching demands. During my Ph.D. study, my work focuses on the development of novel fluorescent sensors for the detection and specific recognition of functional and bio-interesting small molecules and metal ions, and the contents are described in this dissertation using three sections. In the first part, novel fluorescent sensors for the specific recognition of bio-toxic thiophenols have been developed based on ICT and PET mechanism separately. These sensors were designed with an 2,4-dinitrobenzenesulfonamide as the recognition moiety and consequently are able to differentiate thiophenols from bio-active aliphatic thiols such as cysteine in neutral aqueous solution due to their different pKa values. Moreover, the sensor constructed on NBD fluorophore has a long-wavelength emission (> 500 nm) and were employed as the first fluorescent sensor to detect selenocysteine, a special amine acid in body, without interference with other amino acids including similar cysteine. In the second part, we have made our efforts on the detection of explosive peroxides and discovered a highly sensitive and selective fluorescent sensor for peroxy acids. This sensor took advantage of the ring-open mechanism so as to achieve complete 'on-off' switch in the recognition process. Significant fluorescence signals were observed upon addition of peroxy acids while other peroxides and ROS couldn't make influence on the sensor. In the third part, we turned our attention to the bio-interesting metal ions. A turn-on fluorescent sensor has been developed for the detection of bio-active Zn2+ with based on PET mechanism. This sensor is highly selective for Zn2+ and showed no response to numerous metal ions such as K+, Ca2+, Mg2+, Fe3+, Cu2+, Co2+, Cd2+, etc. Moreover, we successfully designed an unprecedented chemodosimeter for the detection of highly toxic Hg2+ in the aqueous solution, which came from a unique Hg2+ facilitated desulfurization—lactonization cascade reaction by transforming a weakly fluorescent precursor to a highly fluorescent coumarin derivative.
Advisors/Committee Members: Wang, Wei, Feng, Changjian, Grey, John, Mariano, Patrick, Wang, Wei.
Subjects/Keywords: fluorescence; sensor; sensitivity; selectivity
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Jiang, W. (2010). Development of novel fluorescent sensors for the detection of functional and bio-interesting small molecules and metal ions. (Doctoral Dissertation). University of New Mexico. Retrieved from https://digitalrepository.unm.edu/chem_etds/4
Chicago Manual of Style (16th Edition):
Jiang, Wei. “Development of novel fluorescent sensors for the detection of functional and bio-interesting small molecules and metal ions.” 2010. Doctoral Dissertation, University of New Mexico. Accessed June 24, 2019.
https://digitalrepository.unm.edu/chem_etds/4.
MLA Handbook (7th Edition):
Jiang, Wei. “Development of novel fluorescent sensors for the detection of functional and bio-interesting small molecules and metal ions.” 2010. Web. 24 Jun 2019.
Vancouver:
Jiang W. Development of novel fluorescent sensors for the detection of functional and bio-interesting small molecules and metal ions. [Internet] [Doctoral dissertation]. University of New Mexico; 2010. [cited 2019 Jun 24].
Available from: https://digitalrepository.unm.edu/chem_etds/4.
Council of Science Editors:
Jiang W. Development of novel fluorescent sensors for the detection of functional and bio-interesting small molecules and metal ions. [Doctoral Dissertation]. University of New Mexico; 2010. Available from: https://digitalrepository.unm.edu/chem_etds/4
University of Illinois – Urbana-Champaign
12.
Griffin, Michael Llewellyn.
A matter of priorities: High working memory enables (slightly) superior value-directed remembering.
Degree: MS, Psychology, 2017, University of Illinois – Urbana-Champaign
URL: http://hdl.handle.net/2142/99299
► People with larger working memory capacity exhibit enhanced free recall but do not show any advantage on tests of recognition. This pair of results suggests…
(more)
▼ People with larger working memory capacity exhibit enhanced free recall but do not show any advantage on tests of recognition. This pair of results suggests that differences in the strategies that people bring to the task of learning and retrieving are superior in learners with high working memory. There is ample evidence that learners with high working memory do indeed bring better strategies to both encoding and retrieval, but as yet little evidence of whether higher working memory is related to greater effectiveness in prioritizing information across materials that differ in value. Using the value-directed remembering paradigm of Castel, Benjamin, Watkins, and Craik (2002), we examined whether learners with high working memory capacity show a particular advantage in remembering materials that are of high value. Across four experiments, we found that high working memory capacity led to a selective preference for remembering high-valued word pairs, but the effect was very modest and does not provide a complete picture of the relationship between working memory and recall.
Advisors/Committee Members: Benjamin, Aaron S. (advisor).
Subjects/Keywords: Working Memory; Cued Recall; Selectivity
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Griffin, M. L. (2017). A matter of priorities: High working memory enables (slightly) superior value-directed remembering. (Thesis). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/99299
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Griffin, Michael Llewellyn. “A matter of priorities: High working memory enables (slightly) superior value-directed remembering.” 2017. Thesis, University of Illinois – Urbana-Champaign. Accessed June 24, 2019.
http://hdl.handle.net/2142/99299.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Griffin, Michael Llewellyn. “A matter of priorities: High working memory enables (slightly) superior value-directed remembering.” 2017. Web. 24 Jun 2019.
Vancouver:
Griffin ML. A matter of priorities: High working memory enables (slightly) superior value-directed remembering. [Internet] [Thesis]. University of Illinois – Urbana-Champaign; 2017. [cited 2019 Jun 24].
Available from: http://hdl.handle.net/2142/99299.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Griffin ML. A matter of priorities: High working memory enables (slightly) superior value-directed remembering. [Thesis]. University of Illinois – Urbana-Champaign; 2017. Available from: http://hdl.handle.net/2142/99299
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Minnesota
13.
Bigert, Matthew.
Selectivity Optimization in Tandem Column Liquid Chromatography Using the Eluent Composition as the Tuning Variable.
Degree: MS, Chemistry, 2018, University of Minnesota
URL: http://hdl.handle.net/11299/201018
► Clearly, in typical separations in HPLC, selectivity is the most important variable for improving resolution and the optimization of selectivity is the primary focus of…
(more)
▼ Clearly, in typical separations in HPLC, selectivity is the most important variable for improving resolution and the optimization of selectivity is the primary focus of most method development effort in reversed-phase liquid chromatography (RPLC). We have developed a family of novel techniques in which two columns with markedly different chromatographic selectivities are combined in tandem. One then uses another chromatographic variable (e.g. temperature, flow rate, eluent composition) which has different values for the two columns to continuously “tune” the selectivity. We call this family of techniques XT2C, meaning that the variable X (temperature, etc.) is used to continuously tune the combined selectivity of the tandem columns. By serially coupling the columns, our approach eliminates the common “selectivity discontinuity” problem encountered by analysts when the type of column used is changed. Previously, we utilized the thermally tuned tandem column (T3C) concept in which selectivity was adjusted by independently tuning the two column temperatures. The primary difference between the experimental setup for T3C and XT2C is that a second pump and static micro-mixer are placed between the two columns. In this study, we describe the eluent tuned tandem column concept in which selectivity is continuously tuned by independently controlling the eluent composition of each column. When the percent organic modifier in the eluent (%B) is adjusted, the concept is denoted “solvent tuned tandem column (ST2C)”. Likewise, when the ionic strength (buffer concentration) is tuned, the concept is referred to as ionic strength tuned tandem column (IT2C). The objective of the present study is to evaluate the applicability of IT2C and ST2C to mixtures of ionic and non-ionic analytes, respectively. We also describe the use of a simple computer assisted optimization strategy based on the window diagram method. This strategy allows for XT2C optimization based on only four to six initial data acquisition runs. ST2C and IT2C are comparable in terms of chromatographic performance to T3C and provide flexibility in optimizing selectivity but do not require thermally stable columns.
Subjects/Keywords: Eluent; HPLC; Selectivity; Tandem
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Bigert, M. (2018). Selectivity Optimization in Tandem Column Liquid Chromatography Using the Eluent Composition as the Tuning Variable. (Masters Thesis). University of Minnesota. Retrieved from http://hdl.handle.net/11299/201018
Chicago Manual of Style (16th Edition):
Bigert, Matthew. “Selectivity Optimization in Tandem Column Liquid Chromatography Using the Eluent Composition as the Tuning Variable.” 2018. Masters Thesis, University of Minnesota. Accessed June 24, 2019.
http://hdl.handle.net/11299/201018.
MLA Handbook (7th Edition):
Bigert, Matthew. “Selectivity Optimization in Tandem Column Liquid Chromatography Using the Eluent Composition as the Tuning Variable.” 2018. Web. 24 Jun 2019.
Vancouver:
Bigert M. Selectivity Optimization in Tandem Column Liquid Chromatography Using the Eluent Composition as the Tuning Variable. [Internet] [Masters thesis]. University of Minnesota; 2018. [cited 2019 Jun 24].
Available from: http://hdl.handle.net/11299/201018.
Council of Science Editors:
Bigert M. Selectivity Optimization in Tandem Column Liquid Chromatography Using the Eluent Composition as the Tuning Variable. [Masters Thesis]. University of Minnesota; 2018. Available from: http://hdl.handle.net/11299/201018
Boston College
14.
Liu, Nanjun.
Chemical Approaches to Understand the On-Membrane Action of
Magainin 2.
Degree: MS, Chemistry, 2011, Boston College
URL: http://dlib.bc.edu/islandora/object/bc-ir:101619
► There is substantial interest in exploring antibiotic alternatives with a new mode of action due to the increasing rates of bacterial resistance against current antibiotics.…
(more)
▼ There is substantial interest in exploring antibiotic
alternatives with a new mode of action due to the increasing rates
of bacterial resistance against current antibiotics. Antimicrobial
peptides (AMPs) may take up the battle against bacteria in the
future because as a result of their membrane-lysis mechanism, it is
more difficult for bacteria to develop resistance against AMPs.
Although AMPs could preferentially bind to and disrupt negatively
charged bacterial membranes through electrostatic and hydrophobic
interactions, there is still a great need to further increase the
potency and selective toxicity towards bacteria for clinical
applications. Herein, we present two strategies to improve the
selectivity: light activation and environment-responsive moiety
incorporation. Along the way, we also explored the effect of
structure stabilization on AMPs action. A well-characterized
antimicrobial peptide magainin 2 (mag2) was used as a prototype.
Chemical manipulations of mag2 sequence were achieved by
incorporation of unnatural amino acids. The
selectivity was then
tested on liposomes as a membrane model, as well as on bacterial
cells and human red blood cells (hRBCs). Different extents of
selectivity enhancement were observed from the modified peptides,
and within the attempts to illustrate these results, we have gained
useful information revealing the membrane-lysis mechanism, which
may help us to rationally design and engineer AMPs as therapeutic
drugs in the future.
Advisors/Committee Members: Mary F. Roberts (Thesis advisor).
Subjects/Keywords: Antibiotics; Antimicrobial peptides; Mechanism; Selectivity
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Liu, N. (2011). Chemical Approaches to Understand the On-Membrane Action of
Magainin 2. (Masters Thesis). Boston College. Retrieved from http://dlib.bc.edu/islandora/object/bc-ir:101619
Chicago Manual of Style (16th Edition):
Liu, Nanjun. “Chemical Approaches to Understand the On-Membrane Action of
Magainin 2.” 2011. Masters Thesis, Boston College. Accessed June 24, 2019.
http://dlib.bc.edu/islandora/object/bc-ir:101619.
MLA Handbook (7th Edition):
Liu, Nanjun. “Chemical Approaches to Understand the On-Membrane Action of
Magainin 2.” 2011. Web. 24 Jun 2019.
Vancouver:
Liu N. Chemical Approaches to Understand the On-Membrane Action of
Magainin 2. [Internet] [Masters thesis]. Boston College; 2011. [cited 2019 Jun 24].
Available from: http://dlib.bc.edu/islandora/object/bc-ir:101619.
Council of Science Editors:
Liu N. Chemical Approaches to Understand the On-Membrane Action of
Magainin 2. [Masters Thesis]. Boston College; 2011. Available from: http://dlib.bc.edu/islandora/object/bc-ir:101619
University of Arizona
15.
Putnam, Philip.
Neural Substrates of Social Behavior in the Primate Brain
.
Degree: 2019, University of Arizona
URL: http://hdl.handle.net/10150/631936
► Many brain structures are known for carrying out more than one function. Among these structures the amygdala emerged particularly versatile, as it has been implicated…
(more)
▼ Many brain structures are known for carrying out more than one function. Among these structures the amygdala emerged particularly versatile, as it has been implicated in cognitive processes that range from sensory-perceptual, to decision-making, and to overt behaviors accompanied by autonomic responses. While no single functional definition can capture its role in the brain, the diversity of functions linked to the amygdala is likely reflected in the response properties of its component neurons. The goal of this study was to determine the extent to which single neurons in the amygdala can exhibit multiple types of stimulus-
selectivity and/or task-related responses in the context of a complex task. The task involved learning and decision making based on stimulus-reward associations where the choices were presented as multiple simultaneously playing videos with social and non-social content. Here we report that amygdala neurons are tuned to multiple stimulus and task dimensions. Furthermore a disproportionate number of neurons responded to all of the features examined. This demonstration of multi-dimensional
selectivity in the amygdala provides evidence that the amygdala is not composed exclusively of discrete circuits, but rather of common overlapping populations that encode multiple types of information.
Advisors/Committee Members: Cowen, Stephen (advisor), Gothard, Katalin (committeemember), Bao, Shaowen (committeemember), Cai, Haijiang (committeemember).
Subjects/Keywords: amygdala;
Multi-dimensional selectivity;
rhesus
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Putnam, P. (2019). Neural Substrates of Social Behavior in the Primate Brain
. (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/631936
Chicago Manual of Style (16th Edition):
Putnam, Philip. “Neural Substrates of Social Behavior in the Primate Brain
.” 2019. Doctoral Dissertation, University of Arizona. Accessed June 24, 2019.
http://hdl.handle.net/10150/631936.
MLA Handbook (7th Edition):
Putnam, Philip. “Neural Substrates of Social Behavior in the Primate Brain
.” 2019. Web. 24 Jun 2019.
Vancouver:
Putnam P. Neural Substrates of Social Behavior in the Primate Brain
. [Internet] [Doctoral dissertation]. University of Arizona; 2019. [cited 2019 Jun 24].
Available from: http://hdl.handle.net/10150/631936.
Council of Science Editors:
Putnam P. Neural Substrates of Social Behavior in the Primate Brain
. [Doctoral Dissertation]. University of Arizona; 2019. Available from: http://hdl.handle.net/10150/631936
University of Toronto
16.
Brown, Trecia.
Development of Neuronal Responses to Frequency-modulated Tones in Chinchilla Auditory Cortex.
Degree: 2010, University of Toronto
URL: http://hdl.handle.net/1807/24695
► A central issue in auditory research is how the auditory brain encodes complex stimuli. However, the process by which the auditory cortex interprets complex sounds…
(more)
▼ A central issue in auditory research is how the auditory brain encodes complex stimuli. However, the process by which the auditory cortex interprets complex sounds during development and the extent to which cortical organization can be manipulated by complex stimulation is still undetermined. We have addressed this gap in the following three studies. First, we characterized the responses of cortical neurons in adult chinchillas to frequency-modulated (FM) stimulation. Next, we asked whether FM coding at the cortical level is innate or if its development is influenced by normal postnatal environmental experience. Finally, we investigated the effect of sustained neonatal FM sweep exposure on the development of cortical responses to tonal and FM stimuli. In our adult study, results indicated that >90% of sampled neurons were responsive to FM sweeps. The population preference was for upward FM sweeps and for medium to fast speeds ( 0.3 kHz/ms). Three types of temporal response patterns were observed: a single peak at sweep onset/offset (‘onset’) and a single peak (‘late’) or multiple peaks (‘burst’) during the sweep. ‘Late’ units expressed the highest direction and speed selectivity; ‘onset’ units were selective only for direction and ‘burst’ units were selective for neither direction nor speed. In our developmental study, our results showed a significant developmental increase in FM direction selectivity. However, FM speed selectivity appeared to be established early in development. In our developmental plasticity study, we hypothesized that constant FM exposure would increase the proportion of auditory neurons that are selectively responsive to the conditioning FM sweep. However, our results showed that while tonal response latencies increased after the exposure period, the conditioning stimulus had minimal effect on the FM direction preferences of cortical neurons and decreased overall neuronal FM speed selectivity. In conclusion, we suggest that chinchilla auditory cortical neurons are not uniquely activated by FM sounds but that FM responses are largely predictable based on how changing frequency stimuli interact with the receptive fields of these neurons. We also propose that the development of FM direction sensitivity is experience-independent and that perhaps normal acoustic experience is required to maintain FM speed tuning.
PhD
Advisors/Committee Members: Harrison, Robert, Physiology.
Subjects/Keywords: FM sweeps; development; direction selectivity; acoustic exposure; speed selectivity; conditioning; 0719
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Brown, T. (2010). Development of Neuronal Responses to Frequency-modulated Tones in Chinchilla Auditory Cortex. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/24695
Chicago Manual of Style (16th Edition):
Brown, Trecia. “Development of Neuronal Responses to Frequency-modulated Tones in Chinchilla Auditory Cortex.” 2010. Doctoral Dissertation, University of Toronto. Accessed June 24, 2019.
http://hdl.handle.net/1807/24695.
MLA Handbook (7th Edition):
Brown, Trecia. “Development of Neuronal Responses to Frequency-modulated Tones in Chinchilla Auditory Cortex.” 2010. Web. 24 Jun 2019.
Vancouver:
Brown T. Development of Neuronal Responses to Frequency-modulated Tones in Chinchilla Auditory Cortex. [Internet] [Doctoral dissertation]. University of Toronto; 2010. [cited 2019 Jun 24].
Available from: http://hdl.handle.net/1807/24695.
Council of Science Editors:
Brown T. Development of Neuronal Responses to Frequency-modulated Tones in Chinchilla Auditory Cortex. [Doctoral Dissertation]. University of Toronto; 2010. Available from: http://hdl.handle.net/1807/24695
Texas A&M University
17.
Boopalachandran, Praveenkumar.
Catalytic studies of supported Pd-Au catalysts.
Degree: 2006, Texas A&M University
URL: http://hdl.handle.net/1969.1/3826
► Although Pd-Au high-surface area catalysts are used in industry to improve activity and selectivity, a thorough understanding of the nature of these enhancements is lacking.…
(more)
▼ Although Pd-Au high-surface area catalysts are used in industry to improve
activity and
selectivity, a thorough understanding of the nature of these enhancements is
lacking. A molecular-level understanding of catalytic reactions under actual reaction
conditions is the ultimate goal. This thesis is mainly focused on the application of Pd-Au
supported catalysts for vinyl acetate synthesis and CO oxidation reactions using highsurface
area catalysts. We have attempted to improve the conventional Pd-Au based
catalyst by synthesizing novel acetate-based and polymer-based catalysts. The
corresponding catalytic reactivity and
selectivity were measured and compared to
conventional Pd-Au based catalyst systems. Subsequent characterization was performed
using characterization techniques, such as, X-ray diffraction (XRD) and transmission
electron microscopy (TEM).
From our bimetallic catalytic studies, it was evident that the addition of Au to Pd
leads to increased reactivity and
selectivity. This surface modification is an important
factor in the altered reaction kinetics for vinyl acetate (VA) synthesis and CO oxidation
reactions. Promoted and unpromoted Pd-Au/SiO2/K+ catalyst were used for VA synthesis
and the effect of pre-adsorbed O2, acetic acid and the role of oxygen were explored. The VA reaction rate of novel acetate-based Pd-Au/SiO2 catalyst was 3.5 times
higher than conventional Pd-Au catalysts. Also, 100%
selectivity was obtained for
acetate-based Pd-Au/SiO2 at 130 °C and the VA formation rate was comparable to that of
conventional Pd-Au catalysts. Therefore, the acetate-based Pd-Au/SiO2 catalyst seems
very promising and can be explored further. Also, Pd(1):Au(4)/SiO2 catalysts
demonstrate 100% CO conversion at much lower temperatures (90 °C) compared with
other Pd-Au based catalysts. Furthermore, we were successful in obtaining sufficient CO
oxidation activity with increased metal loading (5 wt%) and these catalysts did not
deactivate under above-ambient reaction temperature conditions, which make 1:4 Pd-
Au/SiO2 catalyst a good candidate for further exploration in CO oxidation reactions.
Advisors/Committee Members: Goodman, Wayne D. (advisor), Rosynek, Michael P. (committee member), Schaak, Raymond E. (committee member), Shantz, Daniel F. (committee member).
Subjects/Keywords: reaction rate; selectivity
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Boopalachandran, P. (2006). Catalytic studies of supported Pd-Au catalysts. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/3826
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Boopalachandran, Praveenkumar. “Catalytic studies of supported Pd-Au catalysts.” 2006. Thesis, Texas A&M University. Accessed June 24, 2019.
http://hdl.handle.net/1969.1/3826.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Boopalachandran, Praveenkumar. “Catalytic studies of supported Pd-Au catalysts.” 2006. Web. 24 Jun 2019.
Vancouver:
Boopalachandran P. Catalytic studies of supported Pd-Au catalysts. [Internet] [Thesis]. Texas A&M University; 2006. [cited 2019 Jun 24].
Available from: http://hdl.handle.net/1969.1/3826.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Boopalachandran P. Catalytic studies of supported Pd-Au catalysts. [Thesis]. Texas A&M University; 2006. Available from: http://hdl.handle.net/1969.1/3826
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Texas A&M University
18.
Hamilton, Patrick Neal.
The behavior and separation of polystyrene in mixed solvent systems.
Degree: 2009, Texas A&M University
URL: http://hdl.handle.net/1969.1/ETD-TAMU-1256
► Non-polar phase selective solubility of modified poly(4-n-alkylstyrene) supports can be measured using fluorescent dyes as catalyst surrogates with thermomorphic and latent biphasic systems. By modifying…
(more)
▼ Non-polar phase selective solubility of modified poly(4-n-alkylstyrene) supports
can be measured using fluorescent dyes as catalyst surrogates with thermomorphic and
latent biphasic systems. By modifying the solvent compositions in heptane/ethanol and
heptane/N, N-dimethylacetamide, increased non-polar phase selective solubility of
modified polystyrene supports can be attained. Likewise, by varying the structure and
length of the pendant alkyl chain, an increase in non-polar phase selective solubility is
measured. These heptane soluble polymer supports can be useful for applications
involving heptane soluble polymer-bound reagents and catalysts.
Various polar and non-polar polymer supports were synthesized with an attached
solvatochromic catalyst surrogates to determine the solvent accessibility of the supported
species in pure and mixed solvents. The results of these studies indicate that in pure
solvents, the influence of both polar and non-polar polymer supports on the solvent
microenvironment of these polymer-supported probes is minimal. In mixed solvent
systems, a polymer-like solvent microenvironment is measured in solvent mixtures
comprised of solvents the polymer has unfavorable interactions. Poly(4-n-alkylstyrene)
and internally functionalized polyisobutylene supports are two such polymer supports that exhibit this behavior. For terminally functionalized polymers in mixed solvents, the
solvatochromic behavior does not indicate a collapsed structure. In mixed solvents,
there is minimal influence of the polymer support on the solvent microenvironment of
these terminally functionalized polymers.
The application of soluble polyisobutylene supported copper complexes in the
ATRP polymerization of styrene was investigated. Using the difference in solubility of
the product polystyrene and the polyisobutylene copper complex in heptane, a
solid/liquid separation of the soluble copper complex from the solid product was
achieved. The results of these polymerizations indicate that the polyisobutylene copper
complex behaves exactly like a low molecular weight copper complex in terms of
control over molecular weight and molecular weight distribution. After the
polymerizations, the polyisobutylene complexes could be separated as a heptane solution
and recycled in multiple polymerizations of styrene.
Advisors/Committee Members: Bergbreiter, David E. (advisor), Shantz, Daniel F. (committee member), Simanek, Eric E. (committee member), Singleton, Daniel A. (committee member).
Subjects/Keywords: Polystyrene; ATRP; Soluble; Supports; Selectivity; Microenvironment
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Hamilton, P. N. (2009). The behavior and separation of polystyrene in mixed solvent systems. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-1256
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hamilton, Patrick Neal. “The behavior and separation of polystyrene in mixed solvent systems.” 2009. Thesis, Texas A&M University. Accessed June 24, 2019.
http://hdl.handle.net/1969.1/ETD-TAMU-1256.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hamilton, Patrick Neal. “The behavior and separation of polystyrene in mixed solvent systems.” 2009. Web. 24 Jun 2019.
Vancouver:
Hamilton PN. The behavior and separation of polystyrene in mixed solvent systems. [Internet] [Thesis]. Texas A&M University; 2009. [cited 2019 Jun 24].
Available from: http://hdl.handle.net/1969.1/ETD-TAMU-1256.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hamilton PN. The behavior and separation of polystyrene in mixed solvent systems. [Thesis]. Texas A&M University; 2009. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-1256
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Zambia
19.
Obbo, Jovent K.
Men's perception of women and women's self-image in Lusaka, Zambia
.
Degree: 2012, University of Zambia
URL: http://hdl.handle.net/123456789/1724
► There has been a growing concern on the situation of women particularly because of the conscientization , which resulted from the UN women's decade (1976-85)…
(more)
▼ There has been a growing concern on the situation of women particularly because of the conscientization , which resulted from the UN women's decade (1976-85) with its themes, "peace", "development" and "equality". Various reasons have been given for the failure to improve on the situation of women. One of them has been the persistence of traditional attitudes towards them. This study was an attempt to examine the above issue. It looked at both men's perception of women and women's self-image in the Zambian context.The main objectives of the study were to identify how women are perceived by men in the Zambian context; examine whether men's perception of women is influenced by the variables of age, education, marital status, income and place of residence; identify how women in Zambia perceive themselves; find out the relationship between men's perception of women and women's self-image; and whether women's self-image is influenced by the variables of age, education, marital status, place of residence and income. The following were hypothesized: men have a negative perception of women in terms of socio-economic status; women have a negative self-image in terms of socio-economic status; men's perception of women and women's self-image are positively ?^elated to the variables of age, marital status, education, income and place of residence; men's perception of women is positively related to women's self-image.
The study employed the survey design. Data was collected from 200 male and female residents of Lusaka urban. These were Zambian citizens of twenty-one years and above. The person to person interview was utilized. Computer techniques were used to process and analyse the data. In the analysis frequencies, percentages, cross tabulations and correlations (Pearsons Chi-square) were used.
The main findings of the survey were that women in Lusaka, Zambia are generally positively perceived by men and they have a positive self-image, in terms of socio-economic status. This finding did not support the theoretical hypotheses that (1) "men have a negative perception of women" (2) women have a negative-self-image in terms of socio-economic status". The findings partly failed to confirm the hypothesis that "men's perception of women and women's self-image are related to the variables of age and marital status, education, income and residence as mixed results were obtained.
Finally, it was recommended that more education opportunities for women be promoted; agents of socialization be sensitized to socialize members of the society in a way that will make them have high regard for women; efforts be made to have more women in higher occupations in the public sphere; restrictive policies which hinder women's involvement in the public sphere be removed and that future studies concentrate on how culture affects perception of women in Lusaka, Zambia.
Subjects/Keywords: Self Perception;
Perception;
Social Perception;
Selectivity(Psychology)
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Obbo, J. K. (2012). Men's perception of women and women's self-image in Lusaka, Zambia
. (Thesis). University of Zambia. Retrieved from http://hdl.handle.net/123456789/1724
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Obbo, Jovent K. “Men's perception of women and women's self-image in Lusaka, Zambia
.” 2012. Thesis, University of Zambia. Accessed June 24, 2019.
http://hdl.handle.net/123456789/1724.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Obbo, Jovent K. “Men's perception of women and women's self-image in Lusaka, Zambia
.” 2012. Web. 24 Jun 2019.
Vancouver:
Obbo JK. Men's perception of women and women's self-image in Lusaka, Zambia
. [Internet] [Thesis]. University of Zambia; 2012. [cited 2019 Jun 24].
Available from: http://hdl.handle.net/123456789/1724.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Obbo JK. Men's perception of women and women's self-image in Lusaka, Zambia
. [Thesis]. University of Zambia; 2012. Available from: http://hdl.handle.net/123456789/1724
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Georgia Tech
20.
Lin, Chao-Chung.
The attention attraction characteristics of signal words under division of attention.
Degree: MS, Psychology, 2002, Georgia Tech
URL: http://hdl.handle.net/1853/28927
Subjects/Keywords: Attention; Selectivity (Psychology)
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Lin, C. (2002). The attention attraction characteristics of signal words under division of attention. (Masters Thesis). Georgia Tech. Retrieved from http://hdl.handle.net/1853/28927
Chicago Manual of Style (16th Edition):
Lin, Chao-Chung. “The attention attraction characteristics of signal words under division of attention.” 2002. Masters Thesis, Georgia Tech. Accessed June 24, 2019.
http://hdl.handle.net/1853/28927.
MLA Handbook (7th Edition):
Lin, Chao-Chung. “The attention attraction characteristics of signal words under division of attention.” 2002. Web. 24 Jun 2019.
Vancouver:
Lin C. The attention attraction characteristics of signal words under division of attention. [Internet] [Masters thesis]. Georgia Tech; 2002. [cited 2019 Jun 24].
Available from: http://hdl.handle.net/1853/28927.
Council of Science Editors:
Lin C. The attention attraction characteristics of signal words under division of attention. [Masters Thesis]. Georgia Tech; 2002. Available from: http://hdl.handle.net/1853/28927
Queens University
21.
Dafoe, Julian.
Properties of Absorbent Polymer Extractants for the Selective Removal of Target Molecules from Fermentation Systems
.
Degree: Chemical Engineering, 2014, Queens University
URL: http://hdl.handle.net/1974/8575
► This thesis investigated polymer properties for their application as extractants in two-phase partitioning bioreactors (TPPBs), which are intended to remove inhibitory fermentation products as they…
(more)
▼ This thesis investigated polymer properties for their application as extractants in two-phase partitioning bioreactors (TPPBs), which are intended to remove inhibitory fermentation products as they are produced. Three applications of polymer TPPB extractants were studied, followed by an investigation into poly(ether)-based polymers’ affinity toward representative target molecules, to identify properties which confer improved extraction performance.
The first investigation aimed to replace a liquid extractant (silicone oil) using a block copolymer, Hytrel® 8206, in the biotransformation of indene to cis-(1S,2R)-indandiol, a chiral pharmaceutical intermediate, by Pseudomonas putida ATCC55687. The polymer simultaneously delivered substrate and removed the product and by-products to alleviate inhibition, improving operability and productivity relative to silicone oil, which could only deliver substrate. Subsequently, soft segment composition and proportion were varied in different block copolymers to selectively extract product or by-product(s) from the same biotransformation, altering the cells’ production profile. This demonstrated selective polymer extraction to help direct substrate utilization toward the product rather than by-product(s) in complex biotransformations.
The next study was on absorptive extraction of a hydrophilic target molecule, 4-valerolactone, produced by recombinant Pseudomonas putida KT2440, featuring an equilibrium-limited final step. The aim was to demonstrate the first application of equilibrium-pulling using selective product absorption, improving production by 30%. Furthermore, this study showed that limited polymer water absorption is helpful to aid in extraction of hydrophilic target molecules, but high polymer water content compromises selectivity, diminishing the equilibrium-pulling effect.
Finally, the effects of soft block proportion, molecular weight, and chain-end composition on affinity toward representative target molecules, carveol and carvone, were studied using commercial block copolymers and their representative homopolymer components. Target molecule affinity improved at low molecular weights in the absence of polar homopolymer end-groups. End-group polarity had an effect whose direction depended on the polarity of the target molecule, improving affinity toward a third, polar target molecule, 4-valerolactone, thereby providing a means to tailor selectivity. Crystallinity and hard segment proportion were both found to reduce uptake.
This work has provided insights into the selection of polymeric TPPB absorbents by identifying polymer properties which improve affinity and selectivity toward different fermentation target molecules, especially relatively hydrophilic ones. The future design of purpose-built polymer extractants will benefit from considering these findings.
Subjects/Keywords: Polymer;
Absorption;
Partitioning;
Bioreactors;
Selectivity;
Biocatalysis
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Dafoe, J. (2014). Properties of Absorbent Polymer Extractants for the Selective Removal of Target Molecules from Fermentation Systems
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/8575
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Dafoe, Julian. “Properties of Absorbent Polymer Extractants for the Selective Removal of Target Molecules from Fermentation Systems
.” 2014. Thesis, Queens University. Accessed June 24, 2019.
http://hdl.handle.net/1974/8575.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Dafoe, Julian. “Properties of Absorbent Polymer Extractants for the Selective Removal of Target Molecules from Fermentation Systems
.” 2014. Web. 24 Jun 2019.
Vancouver:
Dafoe J. Properties of Absorbent Polymer Extractants for the Selective Removal of Target Molecules from Fermentation Systems
. [Internet] [Thesis]. Queens University; 2014. [cited 2019 Jun 24].
Available from: http://hdl.handle.net/1974/8575.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Dafoe J. Properties of Absorbent Polymer Extractants for the Selective Removal of Target Molecules from Fermentation Systems
. [Thesis]. Queens University; 2014. Available from: http://hdl.handle.net/1974/8575
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
22.
Peng, Bolu.
Synthesis of a Novel Diblock Copolymer and Preparation of Highly Selective Molecularly Imprinted Polymer Nanospheres from It
.
Degree: Chemistry, 2015, Queens University
URL: http://hdl.handle.net/1974/13528
► Crosslinking monomers or a polymer around template molecules and the subsequent removal of the templates yield a polymer matrix containing cavities that resemble the shape…
(more)
▼ Crosslinking monomers or a polymer around template molecules and the subsequent removal of the templates yield a polymer matrix containing cavities that resemble the shape of the templates and bear binding groups that complement those on the template molecules. However, a key challenge facing those molecularly imprinted polymers (MIPs) is the infidelity of the pores generated to the original templates and thus non-specific binding of the pores to analytes other than the template. I report in this thesis a method to improve the selectivity of MIP particles.
I prepared an MIP for a chiral analyte relying not only on the traditional H-bonding interactions between the polymer matrix and the template but also on the - stacking interactions. Specifically, I synthesized a novel diblock copolymer poly(ethylene oxide)226-block-poly[(2-pentafluorocinnamoyloxyethyl methacrylate)75%-ran-[2-(2’-carboxybenzoyloxy)ethyl methacrylate]25%]100 or PEO226-b-P(FEMA75%-r-CA25%)100. While the CA groups were introduced because of their H-bond interactions with carbonyl oxygen and amino group of the chiral template D-phenylalanine anilide, the FEMA units were introduced for their ability to crosslink under the UV irradiation and also for the π-π stacking interactions of the fluorinated FEMA phenyl rings with the phenyl rings of D-phenylalanine anilide. To prepare MIP nanoparticles, I first dispersed the diblock copolymer and D-phenylalanine anilide in chloroform/methanol at 95 vol% of methanol to prepare micelles that bore PEO coronal chains and a P(FEMA-r-CA) core that complexed with D-phenylalanine anilide. I then photocrosslinked the micellar core and locked the FEMA and CA units around the template molecules. In a third step, I extracted out D-phenylalanine anilide using a solvent. I discovered that these crosslinked MIP nanoparticles had a selectivity of 6.3 towards the binding of D-phenylalanine anilide over L-phenylalanine anilide. This represented a 70% increase in selectivity of MIP nanoparticles prepared from an analogous approach by replacing PEO226-b-P(FEMA75%-r-CA25%)100 with PEO226-b-P(CEMA75%-r-CA25%)100, where CEMA is the hydrogenated version of FEMA. I believe that my work pinpoints the opportunity for using π-π stacking interactions between fluorinated and hydrogenated aromatic rings for improving the selectivity of MIPs and the potential of using this interaction in future for developing highly selective MIPs.
Subjects/Keywords: diblock copolymer;
MIPs;
selectivity;
self-assembly
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Peng, B. (2015). Synthesis of a Novel Diblock Copolymer and Preparation of Highly Selective Molecularly Imprinted Polymer Nanospheres from It
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/13528
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Peng, Bolu. “Synthesis of a Novel Diblock Copolymer and Preparation of Highly Selective Molecularly Imprinted Polymer Nanospheres from It
.” 2015. Thesis, Queens University. Accessed June 24, 2019.
http://hdl.handle.net/1974/13528.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Peng, Bolu. “Synthesis of a Novel Diblock Copolymer and Preparation of Highly Selective Molecularly Imprinted Polymer Nanospheres from It
.” 2015. Web. 24 Jun 2019.
Vancouver:
Peng B. Synthesis of a Novel Diblock Copolymer and Preparation of Highly Selective Molecularly Imprinted Polymer Nanospheres from It
. [Internet] [Thesis]. Queens University; 2015. [cited 2019 Jun 24].
Available from: http://hdl.handle.net/1974/13528.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Peng B. Synthesis of a Novel Diblock Copolymer and Preparation of Highly Selective Molecularly Imprinted Polymer Nanospheres from It
. [Thesis]. Queens University; 2015. Available from: http://hdl.handle.net/1974/13528
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Canterbury
23.
McKenzie, Emma Lee.
Evaluation of a parent implemented intervention for food selectivity in children with autism.
Degree: Health Sciences Centre, 2012, University of Canterbury
URL: http://hdl.handle.net/10092/7437
► Food selectivity is a common problem in many children with Autism Spectrum Disorder (ASD). While research into this area is beginning to develop, there are…
(more)
▼ Food selectivity is a common problem in many children with Autism Spectrum Disorder (ASD). While research into this area is beginning to develop, there are currently few studies investigating the use of parent-implemented interventions within this population. The present study aimed to teach parents to implement multi-component behavioural interventions at home to ameliorate the food selectivity of their children. The study also aimed to show that these interventions could increase children’s preference for previously nonpreferred foods. Five children and their parents participated. The interventions delivered to the children were tailored to meet their needs and to fit within the context of their families. Each of these interventions was composed of antecedent, positive reinforcement and escape extinction strategies. Parents recorded their children’s food acceptance and disruptive behaviours during each intervention session. In addition, preference assessments were conducted in order to track changes in the children’s preferences for the target foods. The results showed that all of the parents were able to introduce at least one new food to their children’s diets during the intervention. Further, four of the five children showed an improvement in their preference for the targeted foods. These results were maintained at follow-up, although two of the children had only maintained some of the foods that had been introduced. All of the parents reported that their children consumed more foods at follow-up than they had during baseline and indicated that they thought the interventions had been effective. These results indicate that parents are able to implement multi-component behavioural interventions to increase the range of foods in their children’s diets and improve their children’s preference for these foods.
Subjects/Keywords: Autism; food selectivity; food refusal; intervention; feeding
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
McKenzie, E. L. (2012). Evaluation of a parent implemented intervention for food selectivity in children with autism. (Thesis). University of Canterbury. Retrieved from http://hdl.handle.net/10092/7437
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
McKenzie, Emma Lee. “Evaluation of a parent implemented intervention for food selectivity in children with autism.” 2012. Thesis, University of Canterbury. Accessed June 24, 2019.
http://hdl.handle.net/10092/7437.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
McKenzie, Emma Lee. “Evaluation of a parent implemented intervention for food selectivity in children with autism.” 2012. Web. 24 Jun 2019.
Vancouver:
McKenzie EL. Evaluation of a parent implemented intervention for food selectivity in children with autism. [Internet] [Thesis]. University of Canterbury; 2012. [cited 2019 Jun 24].
Available from: http://hdl.handle.net/10092/7437.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
McKenzie EL. Evaluation of a parent implemented intervention for food selectivity in children with autism. [Thesis]. University of Canterbury; 2012. Available from: http://hdl.handle.net/10092/7437
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
24.
Measor, Kevin.
Intensity Selectivity in the Auditory Cortex of the Pallid Bat, Antrozous pallidus.
Degree: Neuroscience, 2014, University of California – Riverside
URL: http://www.escholarship.org/uc/item/7r60520t
► Adaptations that allow for greater discrimination of low intensity sounds may be important in the echolocation behavior of bats. In this dissertation, we used the…
(more)
▼ Adaptations that allow for greater discrimination of low intensity sounds may be important in the echolocation behavior of bats. In this dissertation, we used the pallid bat, Antrozous pallidus, a gleaning bat of the western United States, as a model to study the adaptations for intensity selectivity present in the auditory cortex. We performed in-vivo extracellular recordings in the auditory cortex of the pallid bat, to determine the cortical organization and mechanisms of intensity selectivity. Downward frequency modulated (DFM) sweeps that approximated echolocation calls were used to study intensity selectivity using a behaviorally relevant sound. We also examined the distribution of Parvalbumin (PV) and Calbindin (CB) expressing cells in cortical regions and thalamic nuclei in the auditory pathway. Immunohistochemical staining was used to determine if the distribution of these calcium binding proteins in cortical and thalamic regions that have been implicated in processing of echolocation calls and how that distribution is different from non-echolocating regions. Lastly we examined the thalamocortical projections to intensity selective neurons in the echolocation region of the auditory cortex. Retrograde tracing from intensity selective and non-selective neurons was used to identify the thalamic nuclei that provided input to those neurons. We show that the region of the auditory cortex that is selective for echolocation calls contains a majority of neurons that are highly selective for low intensity sounds. We discovered that in the pallid bat intensity selectivity is enhanced by using behaviorally relevant stimuli and that high-frequency inhibition in the bat's echolocation call is responsible for this increased selectivity. This suggested a spectrotemporal integration mechanism that can shape intensity selectivity. Cortical mapping, in this study, revealed a systematic organization of intensity selectivity measures. We also discovered a differential staining pattern of calcium binding protein in the cortex as higher percentage of PV+ cells compared to CB+ cells was found in both echolocation call- and non-call regions. CB+ neurons where found in all of the regions of the medial geniculate body of the auditory thalamus, while PV staining was limited to the suprageniculate (SG), a region known to project to echolocation selective regions of the cortex. This study also confirmed previous results showing that echolocation selective regions of the cortex receive projections from all nuclei of the MGB except the lemniscal ventral nucleus, however an organization related to intensity selectivity was not able to be determined in the projections. The results from this dissertation highlight the special adaptations that are present in the auditory cortex of the pallid bat that may be important for processing the low-intensity echolocation call. Deviations from a general mammalian plan or even from other bat species in the properties that lead to these adaptations may strengthen the notion that…
Subjects/Keywords: Neurosciences; Bat; Cortex; Intensity; Pallid; Selectivity; Thalamocortical
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Measor, K. (2014). Intensity Selectivity in the Auditory Cortex of the Pallid Bat, Antrozous pallidus. (Thesis). University of California – Riverside. Retrieved from http://www.escholarship.org/uc/item/7r60520t
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Measor, Kevin. “Intensity Selectivity in the Auditory Cortex of the Pallid Bat, Antrozous pallidus.” 2014. Thesis, University of California – Riverside. Accessed June 24, 2019.
http://www.escholarship.org/uc/item/7r60520t.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Measor, Kevin. “Intensity Selectivity in the Auditory Cortex of the Pallid Bat, Antrozous pallidus.” 2014. Web. 24 Jun 2019.
Vancouver:
Measor K. Intensity Selectivity in the Auditory Cortex of the Pallid Bat, Antrozous pallidus. [Internet] [Thesis]. University of California – Riverside; 2014. [cited 2019 Jun 24].
Available from: http://www.escholarship.org/uc/item/7r60520t.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Measor K. Intensity Selectivity in the Auditory Cortex of the Pallid Bat, Antrozous pallidus. [Thesis]. University of California – Riverside; 2014. Available from: http://www.escholarship.org/uc/item/7r60520t
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Sydney
25.
Veliscek Carolan, Jessica.
New Materials for Selective Separations at the Back End of the Nuclear Fuel Cycle
.
Degree: 2015, University of Sydney
URL: http://hdl.handle.net/2123/14613
► Storage and recycling of nuclear waste are important issues that will increase in importance if nuclear power becomes more widely adopted worldwide. Recycling of used…
(more)
▼ Storage and recycling of nuclear waste are important issues that will increase in importance if nuclear power becomes more widely adopted worldwide. Recycling of used nuclear fuel is of benefit both in terms of increasing the nuclear lifetime (ie the number of years nuclear power will be a viable option for power generation) and decreasing the hazards (radiotoxicity, volume and longevity) of nuclear waste. Currently, most reprocessing of used nuclear fuel is performed using liquid-liquid extraction. However, use of solid sorbent materials has many advantages such the lack of organic solvent wastes. This research involves development of materials that are able to selectively remove specific target elements from solutions of used nuclear fuel. Once loaded with radionuclides, these materials may be utilised as transmutation matrices or wasteforms. Therefore, radiolytically and hydrolytically stable materials able to withstand the conditions of nuclear separations, such as titania and zirconia, have been targeted. Further, ordered porosity has been introduced into these titania and zirconia framework materials to improve their sorption capacity and kinetics. In order to impart selectivity to these materials, organic ligands are incorporated. Functional groups, including phosphonates, amines and peptides, have been chosen or designed based on their selectivity for elements relevant to the nuclear fuel cycle. Elements of interest include uranium, which constitutes >96% of used nuclear fuel and can be recycled; minor actinides, which contribute significantly to the radiotoxicity of nuclear waste and can also be recycled in fast neutron reactors; and lanthanides, which are targets for separation from the minor actinides as their high neutron absorption cross sections prevent transmutation of the minor actinides. Novel hybrid materials have been synthesized and their sorption characteristics, including selectivity, capacity and kinetics, evaluated.
Subjects/Keywords: Separations;
Nuclear;
Sorption;
Selectivity;
Functionalisation;
Porosity
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Veliscek Carolan, J. (2015). New Materials for Selective Separations at the Back End of the Nuclear Fuel Cycle
. (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/14613
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Veliscek Carolan, Jessica. “New Materials for Selective Separations at the Back End of the Nuclear Fuel Cycle
.” 2015. Thesis, University of Sydney. Accessed June 24, 2019.
http://hdl.handle.net/2123/14613.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Veliscek Carolan, Jessica. “New Materials for Selective Separations at the Back End of the Nuclear Fuel Cycle
.” 2015. Web. 24 Jun 2019.
Vancouver:
Veliscek Carolan J. New Materials for Selective Separations at the Back End of the Nuclear Fuel Cycle
. [Internet] [Thesis]. University of Sydney; 2015. [cited 2019 Jun 24].
Available from: http://hdl.handle.net/2123/14613.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Veliscek Carolan J. New Materials for Selective Separations at the Back End of the Nuclear Fuel Cycle
. [Thesis]. University of Sydney; 2015. Available from: http://hdl.handle.net/2123/14613
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Debrecen
26.
Barcsa, Lajos.
State Aid in the European Union
.
Degree: DE – Állam- és Jogtudományi Kar, University of Debrecen
URL: http://hdl.handle.net/2437/241352
A szakdolgozat az Európai Unióról szóló szerződés 107. cikkelyének részletes elemzését tartalmazza. Kifejtésre kerülnek benne az általános gazdasági érdekű szolgáltatások, a szelektivitás elmélete, a piacgazdasági befektető elve. Részletesen bemutatásra kerülnek a megengedett és a megengedhető állami támogatások.
Advisors/Committee Members: Bartha, Ildikó (advisor).Subjects/Keywords: state aid; selectivity
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Barcsa, L. (n.d.). State Aid in the European Union
. (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/241352
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Barcsa, Lajos. “State Aid in the European Union
.” Thesis, University of Debrecen. Accessed June 24, 2019.
http://hdl.handle.net/2437/241352.
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Barcsa, Lajos. “State Aid in the European Union
.” Web. 24 Jun 2019.
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Vancouver:
Barcsa L. State Aid in the European Union
. [Internet] [Thesis]. University of Debrecen; [cited 2019 Jun 24].
Available from: http://hdl.handle.net/2437/241352.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.
Council of Science Editors:
Barcsa L. State Aid in the European Union
. [Thesis]. University of Debrecen; Available from: http://hdl.handle.net/2437/241352
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.
University of Manchester
27.
Eichler, Anja.
Investigations of Self-Sufficient P450cam Monooxygenases
for Activity and Enantioselectivity.
Degree: 2016, University of Manchester
URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:302167
► Catalytic, selective C-H bond activation for the oxidative hydroxylation RH → ROH of simple or complex compounds is of significant interest in synthetic organic chemistry.…
(more)
▼ Catalytic, selective C-H bond activation for the
oxidative hydroxylation RH → ROH of simple or complex compounds is
of significant interest in synthetic organic chemistry. One of the
major classes of enzymes used for C-H bond activation are
cytochrome P450 monooxygenases (EC 1.14.X.X), which can promote
chemo-, regio- and stereoselective oxidations under mild reaction
conditions. For the current study, catalytically self-sufficient
forms of biocatalyst P450cam-RhFRed were investigated. These
self-sufficient P450 systems were previously created by fusing the
reductase domain of P450 RhF (CYP116B2, RhFRed from Rhodococcus
sp.) with the catalytic domain of P450cam (CYP101A1, Pseudomonas
putida), thus mimicking the natural fusion of P450 RhF. The
generation of 93 P450cam-RhFRed variants has expanded the synthetic
toolbox to serve as a basis for exploring the substrate scope
towards ethylbenzenes, substituted alkylbenzenes, 4-ethylphenol and
(+)-pleuromutilin. To select for active mutants from this library
of 93, high throughput screening methods were developed. A pooling
approach was applied in order to express P450s and analyse them
against a panel of non-natural substrates, such as ethylbenzene,
4-ethylphenol and (+)-pleuromutilin in whole cell biotransformation
reactions. The concentration of P450 enzymes was determined using
CO difference spectroscopy in whole cells. The assay was
significantly improved both in terms of speed and safety by using
carbon monoxide releasing molecules as a source of CO rather than
the gas CO itself. These screening studies served as starting point
to identify P450cam-RhFRed mutants for specific reactions. In
particular, a systematic investigation of this library showed
mutants that generated chiral benzyl alcohols with good
enantioselectivities.To interpret these results on a structural
basis, molecular dynamics simulations were used to estimate
enantioselectivity of selected mutants for the regio-isomers of
methylated ethylbenzene derivatives. The results from the molecular
dynamics simulations were broadly consistent with experimentally
determined data and identified the importance of conformational
changes and flexibility of mutant-substrate complexes to enforce
enantioselectivity.
Catalytic, selective C-H bond activation for the
oxidative hydroxylation RH → ROH of simple or complex compounds is
of significant interest in synthetic organic chemistry. One of the
major classes of enzymes used for C-H bond activation are
cytochrome P450 monooxygenases (EC 1.14.X.X), which can promote
chemo-, regio- and stereoselective oxidations under mild reaction
conditions. For the current study, catalytically self-sufficient
forms of biocatalyst P450cam-RhFRed were investigated. These
self-sufficient P450 systems were previously created by fusing the
reductase domain of P450 RhF (CYP116B2, RhFRed from Rhodococcus
sp.) with the catalytic domain of P450cam (CYP101A1, Pseudomonas
putida), thus mimicking the natural fusion of P450 RhF. The
generation of 93 P450cam-RhFRed variants has expanded the…
Advisors/Committee Members: WEBB, SIMON SJ, Webb, Simon, Flitsch, Sabine.
Subjects/Keywords: C-H activation; P450 enzymes; Selectivity
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Eichler, A. (2016). Investigations of Self-Sufficient P450cam Monooxygenases
for Activity and Enantioselectivity. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:302167
Chicago Manual of Style (16th Edition):
Eichler, Anja. “Investigations of Self-Sufficient P450cam Monooxygenases
for Activity and Enantioselectivity.” 2016. Doctoral Dissertation, University of Manchester. Accessed June 24, 2019.
http://www.manchester.ac.uk/escholar/uk-ac-man-scw:302167.
MLA Handbook (7th Edition):
Eichler, Anja. “Investigations of Self-Sufficient P450cam Monooxygenases
for Activity and Enantioselectivity.” 2016. Web. 24 Jun 2019.
Vancouver:
Eichler A. Investigations of Self-Sufficient P450cam Monooxygenases
for Activity and Enantioselectivity. [Internet] [Doctoral dissertation]. University of Manchester; 2016. [cited 2019 Jun 24].
Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:302167.
Council of Science Editors:
Eichler A. Investigations of Self-Sufficient P450cam Monooxygenases
for Activity and Enantioselectivity. [Doctoral Dissertation]. University of Manchester; 2016. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:302167
McGill University
28.
Somers, Neil A.
Elucidation of Enzyme-Substrate Selectivity Using a Quick Quantitative Screening Protocol.
Degree: MS, Department of Chemistry, 1999, McGill University
URL: http://digitool.library.mcgill.ca/thesisfile150601.pdf
► The use of hydro lases as synthetic tools for introducing chirality is well known but the difficulty arises in selecting the best hydrolase for the…
(more)
▼ The use of hydro lases as synthetic tools for introducing chirality is well known but the difficulty arises in selecting the best hydrolase for the chemical problem. In a desire to simplify this process, a method for screening many hydro lases with a pH indicator towards substrates has previously been developed. Presented herein is its use and further development. […]
L'utilisation d'hydrolases, comme outil synthétique afin d'obtenir des molécules chirales, est maintenant bien connue. Cependant, le choix de l'hydrolase la plus appropriée a un problème pose, s'avère encore souvent difficile. C'est pourquoi nous avons développé une méthode de criblage afin de simplifier les procèdes existants. Ce procède, base sur l'utilisation d'un indicateur pHmètrique, permet de tester un grand nombre d'hydrolases sur un nombre tout aussi important de substrats. Cette méthode présentée ici a été utilisée et développée. […]
Advisors/Committee Members: ().
Subjects/Keywords: Enzyme-Substrate Selectivity
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
University of Cambridge
29.
Curk, Tine.
Modelling multivalent interactons
.
Degree: 2016, University of Cambridge
URL: https://www.repository.cam.ac.uk/handle/1810/266916
► A Multivalent entity, which could represent a protein, nanoparticle, polymer, virus or a lipid bilayer, has the ability to form multiple bonds to a substrate.…
(more)
▼ A Multivalent entity, which could represent a protein, nanoparticle, polymer, virus or a lipid bilayer, has the ability to form multiple bonds to a substrate. Hence, a multivalent interaction can be strong, even if the individual bonds are weak. However, much more interestingly, multivalency enables the design of highly specific interactions using non-specific individual bonds. We attempt to rationalise multivalent effects using simple physical models complemented with numerical simulations. Based on physiochemical characteristics of multivalent binders, we aim to predict the overall strength of interaction and its sensitivity to variation in parameters.
We start with a simple model of homo-multivalency, where all bonds are equivalent. Such systems can exhibit a super-selective response, which denotes the high sensitivity of the strength of multivalent binding to the number of accessible binding sites on the target surface. We present a theoretical analysis of systems of multivalent particles and show that a certain degree of disorder is necessary for super-selective behaviour. Moreover, we formulate a set of simple design rules for multivalent interactions that yield optimal selectivity.
In the second stage, we expand the model to hetero-multivalency, accounting for multiple distinct types of binding partners. We consider targeting of cells based on a density profile of different membrane receptors types and demonstrate, that speci city towards a desired receptor density profile can be obtained. Hence, cells can be reliably targeted in the absence of specific markers. Crucially, we show that for optimal selectivity, individual bonds must be weak.
Finally, we add information about specific geometry and positions of binding sites on the multivalent entity. We focus on molecular imprinting; the process whereby a polymer matrix is cross-linked in the presence of template molecules. The cross-linking process endows the polymer matrix with a chemical ‘memory’, such that the target molecules can subsequently be recognised by the matrix. We show how the binding multivalency and the polymer material properties affect the efficiency and selectivity of molecular imprinting.
Subjects/Keywords: multivalency;
selectivity;
Monte Carlo simulations;
statistical mechanics
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Curk, T. (2016). Modelling multivalent interactons
. (Thesis). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/266916
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Curk, Tine. “Modelling multivalent interactons
.” 2016. Thesis, University of Cambridge. Accessed June 24, 2019.
https://www.repository.cam.ac.uk/handle/1810/266916.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Curk, Tine. “Modelling multivalent interactons
.” 2016. Web. 24 Jun 2019.
Vancouver:
Curk T. Modelling multivalent interactons
. [Internet] [Thesis]. University of Cambridge; 2016. [cited 2019 Jun 24].
Available from: https://www.repository.cam.ac.uk/handle/1810/266916.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Curk T. Modelling multivalent interactons
. [Thesis]. University of Cambridge; 2016. Available from: https://www.repository.cam.ac.uk/handle/1810/266916
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Toronto
30.
Kulleperuma, Kulleperuma Kethika.
Molecular Dynamics Study of the Human Voltage-gated Proton Channel, hHV1.
Degree: PhD, 2016, University of Toronto
URL: http://hdl.handle.net/1807/73074
► A membrane protein, the human voltage-gated proton channel (hHV1) is crucial for many physiological processes of a wide range of cell types. Such processes include…
(more)
▼ A membrane protein, the human voltage-gated proton channel (hHV1) is crucial for many physiological processes of a wide range of cell types. Such processes include bacterial killing by white blood cells, allergic responses by basophils, airway pH regulation in respiratory tracts, and sperm maturation. hHV1 is homologous to the voltage sensor domains (VSD) of voltage-gated cation channels. As such, hHV1 is predicted to adopt a four-helix (S1-S4) bundle structure with three highly-conserved Arg residues (R1-R3) on S4 as well as a number of other charged residues on S1-S3. As a channel, hHV1displays a remarkable diversity in ion
selectivity upon mutating residue Asp112 on S1, the putative
selectivity filter of the pore. hHV1carrying single or double point mutations of Asp112 along with Val116 makes the channel either proton-selective, anion-selective, or nonconducting.
The molecular basis for ion and charge
selectivity in hHV1remains unexplained. The lack of an experimentally-resolved native structure for hHV1 has hindered not only the uncovering of the molecular basis for ion permeation and charge
selectivity in hHV1, but also the advancement of its potential applications as a drug target for the treatment of cerebral damage from ischemic stroke as well as of colorectal and breast cancers.
Here, I investigate the molecular basis for ion and charge
selectivity of hHV1, using molecular dynamics simulations. I first present ROMP, a general, computationally-efficient simulation approach to predict the solvation and the orientation of peptides and proteins in lipid bilayers. The method, which employs a biphasic membrane mimetic to accelerate the convergence of solvent properties, is shown to reproduce the solvation and structural fluctuations of various types of membrane proteins and peptides in lipid bilayers.
I then describe the construction and the validation of two homology models (HM) of hHV1 based on three VSD templates and differing in the registry of S4 with respect to S1-S3 helices. By incorporating ROMP, the relative quality of these two models is evaluated using massively-repeated simulations in the biphasic membrane mimetic. The structural properties of the better model are consistent with experimental accessibility data and a priori features of a proton-conducting channel, with a putative proton permeation pathway comprised of an intermittent hydrogen-bonded water chain in a narrow non-polar bottleneck connecting two water-filled crevices lined with charged residues.
Next, I carry out a comparative assessment of the structure and dynamics of wild-type and mutant channels in a lipid bilayer. This analysis reveals a reorganization of the salt-bridge network involving primarily R2 and mutations at positions 112 and/or 116. The presence or absence of charge compensation of R2 by mutations modulates the electrostatic properties of the pore consistently with the proton or anion
selectivity of the mutants, respectively.
Finally, I use free energy simulations to investigate the thermodynamic basis for the movement…
Advisors/Committee Members: Pomès, RÊgis, Biochemistry.
Subjects/Keywords: Channels; Ions; Proteins; Protons; Selectivity; Simulations; 0487
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Kulleperuma, K. K. (2016). Molecular Dynamics Study of the Human Voltage-gated Proton Channel, hHV1. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/73074
Chicago Manual of Style (16th Edition):
Kulleperuma, Kulleperuma Kethika. “Molecular Dynamics Study of the Human Voltage-gated Proton Channel, hHV1.” 2016. Doctoral Dissertation, University of Toronto. Accessed June 24, 2019.
http://hdl.handle.net/1807/73074.
MLA Handbook (7th Edition):
Kulleperuma, Kulleperuma Kethika. “Molecular Dynamics Study of the Human Voltage-gated Proton Channel, hHV1.” 2016. Web. 24 Jun 2019.
Vancouver:
Kulleperuma KK. Molecular Dynamics Study of the Human Voltage-gated Proton Channel, hHV1. [Internet] [Doctoral dissertation]. University of Toronto; 2016. [cited 2019 Jun 24].
Available from: http://hdl.handle.net/1807/73074.
Council of Science Editors:
Kulleperuma KK. Molecular Dynamics Study of the Human Voltage-gated Proton Channel, hHV1. [Doctoral Dissertation]. University of Toronto; 2016. Available from: http://hdl.handle.net/1807/73074
◁ [1] [2] [3] [4] [5] … [23] ▶
. 
Open Access Theses and Dissertations
