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You searched for subject:(rheumatoid arthrits). Showing records 1 – 2 of 2 total matches.

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Temple University

1. Evans, Kyle William. PPAR gamma AND eNOS CONTRIBUTE TO THE RESOLUTION OF CHRONIC INFLAMMATION.

Degree: PhD, 2011, Temple University

Microbiology and Immunology

Chronic inflammation follows defined phases of induction, inflammation, and resolution. The resolution phase requires cycloxygenase-2 (COX-2) activity. This study aims to address what other molecules are required for a functional resolution phase. We demonstrated that in murine collagen-induced arthritis the transcription factor, PPARgamma plays a role in the resolution phase. Inhibition of COX-2 activity results in fewer PPARgamma positive cells in the arthritic synovium. Treatment with a PPARgamma antagonist, SR202, alone, also disrupts the process of resolution. PPARgamma antagonist treatment results in a decrease in eNOS phosphorylation within the arthritic synovium. These observations indicate that PPARgamma may function to regulate eNOS activity. The source of pro-resolving nitric oxide is eNOS but not, iNOS. The effect of COX-2 inhibition on the resolution phase is ameliorated by injection of a PGE2 analog. Restoration of PGE2 levels results in an increase in PPARgamma positive cells in the arthritic synovium which correlates with this restoration of resolution. Thus, this study provides in vivo evidence for the pro-resolving role of PPARgamma and its relationship with PGE2 and eNOS.

Temple University – Theses

Advisors/Committee Members: Chan, Marion M., Fong, Dunne, Eisenstein, Toby K., Piggot, Patrick, Yang, Xiao-Feng, Ashby, Barrie.

Subjects/Keywords: Biology; eNOS; inflammation; PPARgamma; resolution; rheumatoid arthrits

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Evans, K. W. (2011). PPAR gamma AND eNOS CONTRIBUTE TO THE RESOLUTION OF CHRONIC INFLAMMATION. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,197871

Chicago Manual of Style (16th Edition):

Evans, Kyle William. “PPAR gamma AND eNOS CONTRIBUTE TO THE RESOLUTION OF CHRONIC INFLAMMATION.” 2011. Doctoral Dissertation, Temple University. Accessed April 02, 2020. http://digital.library.temple.edu/u?/p245801coll10,197871.

MLA Handbook (7th Edition):

Evans, Kyle William. “PPAR gamma AND eNOS CONTRIBUTE TO THE RESOLUTION OF CHRONIC INFLAMMATION.” 2011. Web. 02 Apr 2020.

Vancouver:

Evans KW. PPAR gamma AND eNOS CONTRIBUTE TO THE RESOLUTION OF CHRONIC INFLAMMATION. [Internet] [Doctoral dissertation]. Temple University; 2011. [cited 2020 Apr 02]. Available from: http://digital.library.temple.edu/u?/p245801coll10,197871.

Council of Science Editors:

Evans KW. PPAR gamma AND eNOS CONTRIBUTE TO THE RESOLUTION OF CHRONIC INFLAMMATION. [Doctoral Dissertation]. Temple University; 2011. Available from: http://digital.library.temple.edu/u?/p245801coll10,197871


Freie Universität Berlin

2. Laube, Anna Maria Birgitta. Highly sulfated macromolecules in the diagnosis and therapy of rheumatoid arthritis.

Degree: 2016, Freie Universität Berlin

Abstract Introduction: Early diagnosis and treatment of rheumatoid arthritis (RA) is one of the most important aspects to create an optimal outcome for patients. Therefore, evaluation and development of new imaging techniques and specific drugs are necessary. Dendritic Polyglycerol Sulfate (dPGS) and Dendritic Polyester Sulfate (dPES) are fully synthetic, polysulfated macromolecules with anti-inflammatory effects inhibiting immigration of leucocytes. Unlike dPGS, the basic structure of dPES consists of ester groups that could allow an improved metabolisation. This thesis examines the potential of these molecules in diagnosis and therapy of arthritis. Methods: Collagen-induced arthritis (CIA) in rats was used for in vivo experiments. To display the inflammatory process in joints, near-infrared fluorescence optical imaging (NIR-FOI) was executed for 24 hours after intravenous injection of Indocyanine green (ICG) conjugated to dPGS and dPES. To examine the therapeutic effect of dPGS and dPES in CIA, the substances were administered subcutaneously for eight to fifteen days. Intensity of symptoms was subsequently quantified by using an arthritisscore. The degree of inflammation was determined by Pappenheim staining of smears of synovial fluid and counting of leucocytes. For analysis of pharmacokinetic properties of dPGS and dPES, the level of substances after treatment were qualitatively determined in tissue sections of inner organs via alcian blue staining. Semi quantitative analysis was performed in a similar way and measured in alcian blue/mm² size of the section or in alcian blue/DNA amount per section. Results: It could be shown that 1\. the signal induced by dPGS-ICG in NIR-FOI of joints with subclinical inflammation is twice as high than in joints of healthy subjects (p≤0,001), 2\. dPGS-ICG and dPES-ICG allow significant discrimination between groups with heavy activity of arthritis and those with low activity of arthritis, 3\. the therapeutic use of dPGS and dPES results in highly significant reduction of clinical symptoms, 4\. dPGS and dPES are found mainly in the liver, spleen and kidney after therapeutic use. Imaging and quantification results raise the hypothesis that dPES may be subject to a higher metabolisation rate than dPGS. Conclusion: For the first time, this study was able to show that dPGS- and dPES-ICG allow the detection of arthritis even in a very early stage. Furthermore, dPGS and dPES are highly effective therapeutic drugs in CIA rats. Consequently, they provide a promising new drug class. Regarding their therapeutic value and pharmacological characteristics they should be further examined to allow improvement of diagnosis and therapy in patients with RA. Advisors/Committee Members: w (gender), N.N. (firstReferee), N.N. (furtherReferee).

Subjects/Keywords: rheumatoid arthritis; collagen-induced arthrits; diagnosis; therapy; fluorescence-imaging; polyglycerol; polyester;

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Laube, A. M. B. (2016). Highly sulfated macromolecules in the diagnosis and therapy of rheumatoid arthritis. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-4839

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Laube, Anna Maria Birgitta. “Highly sulfated macromolecules in the diagnosis and therapy of rheumatoid arthritis.” 2016. Thesis, Freie Universität Berlin. Accessed April 02, 2020. http://dx.doi.org/10.17169/refubium-4839.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Laube, Anna Maria Birgitta. “Highly sulfated macromolecules in the diagnosis and therapy of rheumatoid arthritis.” 2016. Web. 02 Apr 2020.

Vancouver:

Laube AMB. Highly sulfated macromolecules in the diagnosis and therapy of rheumatoid arthritis. [Internet] [Thesis]. Freie Universität Berlin; 2016. [cited 2020 Apr 02]. Available from: http://dx.doi.org/10.17169/refubium-4839.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Laube AMB. Highly sulfated macromolecules in the diagnosis and therapy of rheumatoid arthritis. [Thesis]. Freie Universität Berlin; 2016. Available from: http://dx.doi.org/10.17169/refubium-4839

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.