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University of Tennessee – Knoxville
1.
Samuels, Ronita.
An Epidemiologic Study of Antimicrobial Resistance.
Degree: 2019, University of Tennessee – Knoxville
URL: https://trace.tennessee.edu/utk_graddiss/5703
► The emergence of antimicrobial resistant bacteria has become a serious public health concern. The use of antimicrobials for prophylaxis make it important to estimate the…
(more)
▼ The emergence of antimicrobial resistant bacteria has become a serious public health concern. The use of antimicrobials for prophylaxis make it important to estimate the magnitude of the problem in the animal population. The aim of the second chapter in this study is to investigate the burden and patterns of antimicrobial resistance (AMR) among equine Staphylococcus samples submitted to the University of Kentucky Veterinary Diagnostic Laboratory (UKVDL) from 1993 to 2009. The proportion of resistant isolates by animal breed, species of organism, sample source, and time period were computed. Chi-square and Cochran-Armitage trend tests were used to identify significant associations and temporal trends, respectively. Logistic regression models were used to investigate predictors of AMR and multidrug resistance (MDR).In addition to the problem of antimicrobial resistant bacteria, appropriate usage of antimicrobials is also a global public health concern where opinions regarding appropriate use vary greatly amongst veterinarians. Therefore, the objectives of the third chapter of this study are to investigate the opinions, knowledge and perceptions of veterinarians in Kentucky regarding AMR and antimicrobial prescription practices as well as to identify predictors of their knowledge and opinions. This cross-sectional study uses a 30-question survey questionnaire administered to members of the Kentucky Veterinary Medical Association (KVMA). The proportion of responses to survey questions and 95% confidence intervals were computed. Predictors of improper use of antimicrobials and antimicrobial prescription practices of the respondents as well as their colleagues were investigated using multinomial logistic regression models.The appropriate usage of antimicrobials is also an important topic in developing countries such as South Africa. Thus, the fourth chapter in this study investigates the knowledge, prescription practices and attitudes towards AMR among veterinarians in the City of Tshwane, Metropolitan Municipality. A 30-question survey was administered and the percentages of responses to survey questions and their 95% confidence intervals will be computed. Ordinary logistic models are used to investigate predictors of knowledge of antimicrobial resistance and antimicrobial prescription practices of respondents. Predictors of antimicrobial prescription practices of respondents’ colleagues are identified using multinomial logistic models.
Subjects/Keywords: Antimicrobial Resistance; multidrug resistance; Staphylococcus
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APA (6th Edition):
Samuels, R. (2019). An Epidemiologic Study of Antimicrobial Resistance. (Doctoral Dissertation). University of Tennessee – Knoxville. Retrieved from https://trace.tennessee.edu/utk_graddiss/5703
Chicago Manual of Style (16th Edition):
Samuels, Ronita. “An Epidemiologic Study of Antimicrobial Resistance.” 2019. Doctoral Dissertation, University of Tennessee – Knoxville. Accessed March 02, 2021.
https://trace.tennessee.edu/utk_graddiss/5703.
MLA Handbook (7th Edition):
Samuels, Ronita. “An Epidemiologic Study of Antimicrobial Resistance.” 2019. Web. 02 Mar 2021.
Vancouver:
Samuels R. An Epidemiologic Study of Antimicrobial Resistance. [Internet] [Doctoral dissertation]. University of Tennessee – Knoxville; 2019. [cited 2021 Mar 02].
Available from: https://trace.tennessee.edu/utk_graddiss/5703.
Council of Science Editors:
Samuels R. An Epidemiologic Study of Antimicrobial Resistance. [Doctoral Dissertation]. University of Tennessee – Knoxville; 2019. Available from: https://trace.tennessee.edu/utk_graddiss/5703

University of Utah
2.
Tidwell, Timothy James.
Insulin signaling in the hearts of uncoupling protein three knockout mice on a high fat diet.
Degree: Honors BS;, Biology;, 2009, University of Utah
URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1658/rec/651
► INTRODUCTION: People with diabetes are at high risk for cardiovascular disease; which is the major cause of death in diabetics. Current research suggests that excessive…
(more)
▼ INTRODUCTION: People with diabetes are at high risk for cardiovascular disease; which is the major cause of death in diabetics. Current research suggests that excessive mitochondrial uncoupling is a potential mechanism for cardiac dysfunction in diabetic patients. Uncoupling protein 3 (UCP3) is an inner mitochondrial membrane protein that reduces the amount of reactive oxygen species (ROS) produced in the mitochondrial matrix by uncoupling the mitochondria. Mice lacking UCP3 (UCP3KO) have been shown to accumulate ROS and diacylglycerol in cardiac muscle. These two molecules have been shown to induce insulin resistance in skeletal muscle. The goal of my project was to determine if the absence of UCP3 in the heart will exacerbate diet-induced insulin resistance in the murine heart. MATERIALS AND METHODS: Whole heart homogenates were extracted from four groups of mice: (1) wild type (WT) fed normal chow (NC); (2) WT fed a high fat diet for 10 weeks (HF); (3) UCP3KO NC and (4) UCP3KO HF. Insulin signaling was examined using western-blotting to assess the phosphorylation status of key components of the insulin signaling pathway under non insulin and insulin-stimulated conditions in each group. Values form each group were analyzed using an ANOVA followed by a t test to determine any statistical significant differences between the groups. RESULTS: Phosphorylation of protein kinase B (Akt) (at serine 473 or threonine 308) and the downstream target glycogen synthase kinase 3 p at serine 9 was the same between all the groups. CONCLUSIONS: two major conclusions arise from this work; ( 1 ) 1 0 weeks of high fat diet does not affect insulin signaling in the heart and (2) despite increased ROS and DAG levels in the hearts of UCP3KO mice, insulin sensitivity was maintained. We speculate that UCP3KO mice have developed compensatory mechanisms that prevented the development of insulin resistance despite accumulation of compounds known to induce insulin resistance. These mechanisms remain to be determined in future studies.
Subjects/Keywords: Insulin resistance
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APA (6th Edition):
Tidwell, T. J. (2009). Insulin signaling in the hearts of uncoupling protein three knockout mice on a high fat diet. (Masters Thesis). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1658/rec/651
Chicago Manual of Style (16th Edition):
Tidwell, Timothy James. “Insulin signaling in the hearts of uncoupling protein three knockout mice on a high fat diet.” 2009. Masters Thesis, University of Utah. Accessed March 02, 2021.
http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1658/rec/651.
MLA Handbook (7th Edition):
Tidwell, Timothy James. “Insulin signaling in the hearts of uncoupling protein three knockout mice on a high fat diet.” 2009. Web. 02 Mar 2021.
Vancouver:
Tidwell TJ. Insulin signaling in the hearts of uncoupling protein three knockout mice on a high fat diet. [Internet] [Masters thesis]. University of Utah; 2009. [cited 2021 Mar 02].
Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1658/rec/651.
Council of Science Editors:
Tidwell TJ. Insulin signaling in the hearts of uncoupling protein three knockout mice on a high fat diet. [Masters Thesis]. University of Utah; 2009. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1658/rec/651
3.
Rawat, Aditi.
Prescriptions, Perceptions and Resistance - A Qualitative
Study of Public Perceptions of Antibiotic Prescriptions in Noida,
India.
Degree: School of Public Health, 2017, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:733487/
► Background/Objective: The burden of antibiotic resistance is growing and the lack of adherence to antibiotics is a major reason for its increase. Little is known…
(more)
▼ Background/Objective: The burden of antibiotic
resistance is growing and the lack of adherence to antibiotics is a
major reason for its increase. Little is known about the impact of
patients’ perceptions regarding antibiotic prescriptions and
doctor-patient communication on adherence to antibiotics. This
study assesses patients’ views of their doctors, antibiotic
prescriptions and barriers to antibiotic adherence. Design:
Qualitative, semi-structured one on one interviews. Settings:
Residential complex in Noida, Uttar Pradesh, India (2016)
Participants: Individuals of low socioeconomic status, above 20
years of age working in the residential complex. Results: Negative
interactions with doctors were found to be associated with lack of
adherence to antibiotics. Several participants indicated they
misuse antibiotics. The study found barriers, such as the cost of
medication and consultation, distance from health facility, and use
of traditional methods, to impede the effective use of antibiotics.
The study also found that none of the participants had any
knowledge about antibiotic
resistance. Conclusions: Doctor-patient
interaction is crucial to patients’ opinion about antibiotics and
impacts adherence to antibiotic therapy. More attention is needed
regarding communication between a patient and a doctor and how
patients view antibiotic therapy. Focus is also required to educate
patients about antibiotic
resistance effectively.
Advisors/Committee Members: Shield, Renée R. (Advisor), McGarvey, Stephen T. (Reader).
Subjects/Keywords: Antibiotics Resistance
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Rawat, A. (2017). Prescriptions, Perceptions and Resistance - A Qualitative
Study of Public Perceptions of Antibiotic Prescriptions in Noida,
India. (Thesis). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:733487/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Rawat, Aditi. “Prescriptions, Perceptions and Resistance - A Qualitative
Study of Public Perceptions of Antibiotic Prescriptions in Noida,
India.” 2017. Thesis, Brown University. Accessed March 02, 2021.
https://repository.library.brown.edu/studio/item/bdr:733487/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Rawat, Aditi. “Prescriptions, Perceptions and Resistance - A Qualitative
Study of Public Perceptions of Antibiotic Prescriptions in Noida,
India.” 2017. Web. 02 Mar 2021.
Vancouver:
Rawat A. Prescriptions, Perceptions and Resistance - A Qualitative
Study of Public Perceptions of Antibiotic Prescriptions in Noida,
India. [Internet] [Thesis]. Brown University; 2017. [cited 2021 Mar 02].
Available from: https://repository.library.brown.edu/studio/item/bdr:733487/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Rawat A. Prescriptions, Perceptions and Resistance - A Qualitative
Study of Public Perceptions of Antibiotic Prescriptions in Noida,
India. [Thesis]. Brown University; 2017. Available from: https://repository.library.brown.edu/studio/item/bdr:733487/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
4.
Wong, Neelum.
Development of Improved Chemotherapeutics in Pancreatic and
Colorectal Cancer: Ceramide as a Potential Adjuvant with Sigma-2
Receptor Ligands.
Degree: Department of Molecular Pharmacology, Physiology and
Biotechnology, 2018, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:792844/
► Pancreatic and colorectal cancer are highly aggressive and challenging to treat. Both cancers have low survival rates and there is a need for more elaborate…
(more)
▼ Pancreatic and colorectal cancer are highly aggressive
and challenging to treat. Both cancers have low survival rates and
there is a need for more elaborate therapies as patients suffer
from drug
resistance to commonly used chemotherapeutics. The
difficulty in finding novel and effective treatments has led
researchers to explore the sigma-2 receptor and the sphingolipid
ceramide for their roles in inducing apoptosis in cancer cells.
Ceramide has recently been studied for its ability to potentiate
chemotherapeutics for pancreatic and colorectal cancer patients
with a mutation in the KRAS oncogene that contributes to drug
resistance. The sigma-2 receptor is upregulated in cancer cells and
a cytotoxic response by the activation of the receptor in cancer
cells is a property that can be exploited in the attempt to
overcome drug
resistance and kill pancreatic and colorectal cancer
cells. Here, the cytotoxicity of C-6 ceramide on cell viability for
PANC-1, MIA PaCA-2, and L3.6 pancreatic cancer cell lines and
KRAS-wild-type SW48 and KRAS-mutated SW480 colorectal cell lines
was found using the MTT cell viability assay. Additionally, this
study revealed that a combination treatment of C-6 ceramide with
the sigma-2 receptor agonists, siramesine and SV119 had a
synergistic effect on cytotoxicity while C-6 ceramide with the
sigma-2 receptor agonist, MAM03055A had an additive effect on the
colorectal cancer cell lines. Interestingly, no difference in
cytotoxicity was observed in the combination therapy treatments
between the KRAS-wild-type and KRAS-mutated cell lines. Altogether,
this data suggests that a combination treatment of ceramide with
sigma-2 receptor agonists is promising for the development of
improved chemotherapeutics for pancreatic and colorectal
cancer.
Advisors/Committee Members: Mathiowitz, Edith (Reader), Morgan, Jeffrey (Reader), Bowen, Wayne (Advisor).
Subjects/Keywords: Drug resistance
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Wong, N. (2018). Development of Improved Chemotherapeutics in Pancreatic and
Colorectal Cancer: Ceramide as a Potential Adjuvant with Sigma-2
Receptor Ligands. (Thesis). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:792844/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Wong, Neelum. “Development of Improved Chemotherapeutics in Pancreatic and
Colorectal Cancer: Ceramide as a Potential Adjuvant with Sigma-2
Receptor Ligands.” 2018. Thesis, Brown University. Accessed March 02, 2021.
https://repository.library.brown.edu/studio/item/bdr:792844/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Wong, Neelum. “Development of Improved Chemotherapeutics in Pancreatic and
Colorectal Cancer: Ceramide as a Potential Adjuvant with Sigma-2
Receptor Ligands.” 2018. Web. 02 Mar 2021.
Vancouver:
Wong N. Development of Improved Chemotherapeutics in Pancreatic and
Colorectal Cancer: Ceramide as a Potential Adjuvant with Sigma-2
Receptor Ligands. [Internet] [Thesis]. Brown University; 2018. [cited 2021 Mar 02].
Available from: https://repository.library.brown.edu/studio/item/bdr:792844/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Wong N. Development of Improved Chemotherapeutics in Pancreatic and
Colorectal Cancer: Ceramide as a Potential Adjuvant with Sigma-2
Receptor Ligands. [Thesis]. Brown University; 2018. Available from: https://repository.library.brown.edu/studio/item/bdr:792844/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
5.
Durmus, Naside Gozde.
Enhanced Efficacy of Nanotechnology-Driven Approaches
against Antibiotic-Resistant Biofilms in the Presence of
Metabolites.
Degree: PhD, Biomedical Engineering, 2013, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:320579/
► Antibiotic resistance and the lack of new antimicrobial therapies create significant challenges for the treatment of infections. Therefore, there is an urgent clinical need to…
(more)
▼ Antibiotic
resistance and the lack of new
antimicrobial therapies create significant challenges for the
treatment of infections. Therefore, there is an urgent clinical
need to develop novel treatments targeting bacterial biofilms to
reduce the risk of infection, without resorting to antibiotics. The
goal of this thesis is, for the first time, to integrate two novel
approaches, i.e. nanotechnology and metabolic stimulation, to
eradicate antibiotic-resistant biofilms. The metabolic
microenvironment of the biofilms has been manipulated to improve
the antibacterial properties of superparamagnetic iron oxide
nanoparticles (SPION) as well as nanorough device surfaces. First,
it has been shown that engineered nanoscale topographies provide
surfaces that are more resistant to bacterial growth than
conventional polyvinyl chloride (PVC). In addition, for the first
time, the presence of fructose on the nanorough PVC further
decreased the planktonic S. aureus growth and biofilm formation,
without use of any antibiotics. Moreover, a simple, broad-spectrum
and low-cost dual-sided approach which uses SPION in combination
with metabolites (i.e., fructose, glucose, and mannitol) has been
developed as an alternative to existing antibacterial strategies.
This strategy offers further improved efficacy of SPION against
persistent gram-positive and gram-negative bacteria infections by
manipulating the biofilm metabolic microenvironment, creating a new
nanotechnology-driven approach. Further, biofilm eradication by the
engineered SPION was significantly better than vancomycin, the
antibiotic of last resort. In addition, it has been demonstrated
that SPION conjugated with antibacterial silver salts exhibit
strong eradication properties against the antibiotic-resistant
(MRSA) biofilms. Antibacterial properties of silver-conjugated
SPION were further improved when an external magnetic field was
applied as their magnetic core enabled them to penetrate into the
biofilms. This thesis, for the first time, highlighted the
importance of biofilm metabolic microenvironment for the
nanotechnology-driven approaches. It is envisioned that these
simple and inexpensive approaches could lead to novel alternative
treatments to the only current clinical option, vancomycin, which
MRSA has started to develop a
resistance towards. These novel
nanotechnology-driven approaches can lead to successful clinical
outcomes in terms of minimizing infections, longer medical device
lifetimes, and decreasing antibiotic usage.
Advisors/Committee Members: Webster, Thomas (Director), Webster, Thomas (Reader), Tripathi, Anubhav (Reader), Sun, Shouheng (Reader), Morgan, Jeffrey (Reader), Tripathi, Anubhav (Director).
Subjects/Keywords: antibiotic resistance
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Durmus, N. G. (2013). Enhanced Efficacy of Nanotechnology-Driven Approaches
against Antibiotic-Resistant Biofilms in the Presence of
Metabolites. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:320579/
Chicago Manual of Style (16th Edition):
Durmus, Naside Gozde. “Enhanced Efficacy of Nanotechnology-Driven Approaches
against Antibiotic-Resistant Biofilms in the Presence of
Metabolites.” 2013. Doctoral Dissertation, Brown University. Accessed March 02, 2021.
https://repository.library.brown.edu/studio/item/bdr:320579/.
MLA Handbook (7th Edition):
Durmus, Naside Gozde. “Enhanced Efficacy of Nanotechnology-Driven Approaches
against Antibiotic-Resistant Biofilms in the Presence of
Metabolites.” 2013. Web. 02 Mar 2021.
Vancouver:
Durmus NG. Enhanced Efficacy of Nanotechnology-Driven Approaches
against Antibiotic-Resistant Biofilms in the Presence of
Metabolites. [Internet] [Doctoral dissertation]. Brown University; 2013. [cited 2021 Mar 02].
Available from: https://repository.library.brown.edu/studio/item/bdr:320579/.
Council of Science Editors:
Durmus NG. Enhanced Efficacy of Nanotechnology-Driven Approaches
against Antibiotic-Resistant Biofilms in the Presence of
Metabolites. [Doctoral Dissertation]. Brown University; 2013. Available from: https://repository.library.brown.edu/studio/item/bdr:320579/
6.
Vecchione, James J.
Using Chemical, Genetic, and Biochemical Approaches to
Understand and Circumvent Antibacterial Drug Resistance.
Degree: PhD, Chemistry, 2011, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:11186/
► The growing number of drug-resistant pathogenic bacteria is an impending public health crisis. Unfortunately, the rate at which pathogenic bacteria are developing resistance to our…
(more)
▼ The growing number of drug-resistant pathogenic
bacteria is an impending public health crisis. Unfortunately, the
rate at which pathogenic bacteria are developing
resistance to our
existing battery of anti-infective drugs is greater than the rate
at which new drugs are being developed. We pursued two
complementary strategies to address the problem of antibacterial
resistance. Firstly, we studied
resistance to indolmycin, a member
of a promising class of antibiotics known as the aminoacyl-tRNA
synthetase inhibitors. To elucidate the potential clinical utility
of indolmycin, we analyzed innate mechanisms of
resistance in
Streptomyces bacteria and assessed the distribution of indolmycin
resistance genes in the genomes of various bacterial genera. Our
combined genetic, biochemical, and bioinformatic approaches yielded
insights that are relevant to the development of aminoacyl-tRNA
synthetase inhibitors as antibacterial drugs. Secondly, we studied
ways to deactivate or circumvent antibiotic
resistance mechanisms
in bacteria. In particular, we demonstrated that indolmycin can
suppress multi-drug
resistance phenotypes via perturbation of
protein synthesis and showed that C-capped dipeptides can
potentiate the activity of chloramphenicol via inhibition of major
facilitator superfamily drug efflux pumps.
Advisors/Committee Members: Sello, Jason (Director), Suggs, J. William (Reader), Seto, Christopher (Reader).
Subjects/Keywords: Antibiotic Resistance
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Vecchione, J. J. (2011). Using Chemical, Genetic, and Biochemical Approaches to
Understand and Circumvent Antibacterial Drug Resistance. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:11186/
Chicago Manual of Style (16th Edition):
Vecchione, James J. “Using Chemical, Genetic, and Biochemical Approaches to
Understand and Circumvent Antibacterial Drug Resistance.” 2011. Doctoral Dissertation, Brown University. Accessed March 02, 2021.
https://repository.library.brown.edu/studio/item/bdr:11186/.
MLA Handbook (7th Edition):
Vecchione, James J. “Using Chemical, Genetic, and Biochemical Approaches to
Understand and Circumvent Antibacterial Drug Resistance.” 2011. Web. 02 Mar 2021.
Vancouver:
Vecchione JJ. Using Chemical, Genetic, and Biochemical Approaches to
Understand and Circumvent Antibacterial Drug Resistance. [Internet] [Doctoral dissertation]. Brown University; 2011. [cited 2021 Mar 02].
Available from: https://repository.library.brown.edu/studio/item/bdr:11186/.
Council of Science Editors:
Vecchione JJ. Using Chemical, Genetic, and Biochemical Approaches to
Understand and Circumvent Antibacterial Drug Resistance. [Doctoral Dissertation]. Brown University; 2011. Available from: https://repository.library.brown.edu/studio/item/bdr:11186/

University of Debrecen
7.
Tosin, Ogungbemile.
Employee resistance towards organizational changes
.
Degree: DE – TEK – Közgazdaság- és Gazdaségtudományi Kar, 2011, University of Debrecen
URL: http://hdl.handle.net/2437/118063
► I want to show my sincere gratitude to all those who made this study possible. First of all, i am very thankful to the helpful…
(more)
▼ I want to show my sincere gratitude to all those who made this study possible. First of all, i am very thankful to the helpful staff of University OF Debrecen. One of the most important tasks in every good study is its critical evaluation and feedback which was performed by my supervisor Eniko szilagyi. I am are very thankful to my supervisor for investing her precious time to discuss and criticize this study in depth, and explained the meaning of different concepts . All this, made my tasks very interesting and challenging to me, it also provided me an opportunity to remove any flaws and weaknesses. A warm thanks to Mr Sola who provided me guidance on how to start. I also want to appreciate the efforts of all the staff, senior managements and owner of the firm understudy, who so openly and warmly welcomed me to use previous observations and take in-depth interviews and discussions about the work. My sincere thanks goes to my family members, who indirectly participated in this study by encouraging and supporting me.
Advisors/Committee Members: Szilagyi, Eniko (advisor).
Subjects/Keywords: employee resistance
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Tosin, O. (2011). Employee resistance towards organizational changes
. (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/118063
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Tosin, Ogungbemile. “Employee resistance towards organizational changes
.” 2011. Thesis, University of Debrecen. Accessed March 02, 2021.
http://hdl.handle.net/2437/118063.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Tosin, Ogungbemile. “Employee resistance towards organizational changes
.” 2011. Web. 02 Mar 2021.
Vancouver:
Tosin O. Employee resistance towards organizational changes
. [Internet] [Thesis]. University of Debrecen; 2011. [cited 2021 Mar 02].
Available from: http://hdl.handle.net/2437/118063.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Tosin O. Employee resistance towards organizational changes
. [Thesis]. University of Debrecen; 2011. Available from: http://hdl.handle.net/2437/118063
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manitoba
8.
Wierzbowski, Aleksandra K.
Evolution and molecular characterization of clinical respiratory macrolide-resistant Streptococcus pneumoniae in Canada.
Degree: Medical Microbiology, 2012, University of Manitoba
URL: http://hdl.handle.net/1993/5072
► The purpose of this thesis was to molecularly characterize macrolide-resistant S. pneumoniae (SPN) isolates in Canada between 1998 and 2008. The characterization involved looking at…
(more)
▼ The purpose of this thesis was to molecularly characterize macrolide-resistant S. pneumoniae (SPN) isolates in Canada between 1998 and 2008. The characterization involved looking at the multi-drug resistant phenotype (MDR), the mechanisms of macrolide
resistance, the genetic relatedness, the serotype distribution and PCV7 vaccine coverage as well as the determination of presence of pili-virulence factors. The hypothesis of the study was that macrolide-resistant SPN will growingly be MDR, genetically related, piliated and consisting of serotypes not found in PCV7 vaccine.
Over 1500 macrolide-resistant SPN isolates collected between 1998 and 2008 were studied. Macrolide-resistant isolates came from patients from all regions of Canada, and from all age groups. They came from slightly more males (60%) and slightly more in-patients (62%). Macrolide resistant SPN remained low at 8% during the first 4 years of the study, and started to increase reaching 22% by the end of the study in 2008 (p=0.001). Overall the most common mechanism of
resistance was efflux mediated by mef(A) (51%), followed by target site modification mediated by erm(B) (36%). The efflux mediated macrolide
resistance in S. pneumoniae was predominantly due to the presence of subtype E (95%), which was resistant to more antibiotic classes, and was genetically and serotypically more diverse than the A subtype. Isolates carrying both erm(B) and mef(A) macrolide
resistance genes increased overtime from 1% (1998) to 19% (2008) (p=0.002). Serotype distribution showed a decrease in PCV7 vaccine coverage from 67% to 31% (p=0.0072). Isolates with non-PCV7 serotypes increased overtime from 33% to 57% (p=0.0152).
Isolates with serotype 19A increased by 15% (p=0.005). They were found to be multi-drug resistant, carried both erm(B) and mef(A) subtype E macrolide
resistance genes, and were genetically related. The presence of virulence factor pili-type 1 (PI-1) and pili-type 2 (PI-2) was found associated with these isolates, possibly contributing to its emergence. In conclusion, macrolide resistant SPN increased during the course of this study mostly due to emergence of multi-drug resistant, genetically related, piliated, 19A S. pneumoniae.
Advisors/Committee Members: Zhanel, George (Medical Microbiology) (supervisor), Embree, Joanne (Medical Microbiology) Worobec, Elizabeth (Microbiology) Mulvey, Michael (Medical Microbiology) Hoban, Daryl (Medical Microbiology) Farrell, David (JMI Laboratories) (examiningcommittee).
Subjects/Keywords: Resistance; Macrolides
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APA (6th Edition):
Wierzbowski, A. K. (2012). Evolution and molecular characterization of clinical respiratory macrolide-resistant Streptococcus pneumoniae in Canada. (Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/5072
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Wierzbowski, Aleksandra K. “Evolution and molecular characterization of clinical respiratory macrolide-resistant Streptococcus pneumoniae in Canada.” 2012. Thesis, University of Manitoba. Accessed March 02, 2021.
http://hdl.handle.net/1993/5072.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Wierzbowski, Aleksandra K. “Evolution and molecular characterization of clinical respiratory macrolide-resistant Streptococcus pneumoniae in Canada.” 2012. Web. 02 Mar 2021.
Vancouver:
Wierzbowski AK. Evolution and molecular characterization of clinical respiratory macrolide-resistant Streptococcus pneumoniae in Canada. [Internet] [Thesis]. University of Manitoba; 2012. [cited 2021 Mar 02].
Available from: http://hdl.handle.net/1993/5072.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Wierzbowski AK. Evolution and molecular characterization of clinical respiratory macrolide-resistant Streptococcus pneumoniae in Canada. [Thesis]. University of Manitoba; 2012. Available from: http://hdl.handle.net/1993/5072
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manitoba
9.
Wang, Duoduo.
Transferring blackleg resistance from Brassica carinata and synthetic hexaploid Brassica accessions into Brassica napus.
Degree: Plant Science, 2016, University of Manitoba
URL: http://hdl.handle.net/1993/31196
► Blackleg caused by Leptosphaeria maculans (Desm.) Ces. & De Not. is one of the most serious diseases in canola production. A high level of blackleg…
(more)
▼ Blackleg caused by Leptosphaeria maculans (Desm.) Ces. & De Not. is one of the most serious diseases in canola production. A high level of blackleg
resistance has been shown in Brassica carinata A. Braun (BBCC) and new synthetic hexaploid Brassica species (AABBCC) developed from the crosses of B. rapa L. and B. carinata. Blackleg
resistance from B. carinata and hexaploid Brassica accessions was transferred into B. napus L. using interspecific hybridization followed by backcrossing to a susceptible B. napus cultivar ‘Westar’ three or four times and selfing one or two times to produce pure lines. Leptosphaeria maculans isolate 03-15-03 was used to select the resistant plants in each generation using cotyledon inoculation, and four L. maculans isolates (03-15-03, 3-42-6, 09stonewall9553, and PG4-1-M) were utilized in advanced generations. In the cross of B. napus ‘Westar’ and B. carinata, all plants in the F1 showed a high level of
resistance to L. maculans isolate 03-15-03. According to the chi-square testing for goodness of fit, the segregation of resistant and susceptible plants fit a 1:1 ratio in the BC1, BC3, and BC4. In the BC3F2, two families followed a 3:1 segregation ratio of resistant and susceptible plants. The results suggest that the
resistance to L. maculans transferred from B. carinata into canola ‘Westar’ was controlled by a single locus.
Embryo rescue tissue culture was used to obtain F1 plants of the crosses of ‘Westar’ and synthetic hexaploid Brassica accessions. In the BC1 and BC2, most families did not fit a 1:1 segregation ratio of resistant and susceptible plants. The segregation of resistant and susceptible plants fit a 3:1 ratio when inoculated with L. maculans isolates in the BC1F2-3.1.1s and BC1F3-3.1.1.1ss families. Meanwhile, the BC2-3.1.1 family also followed a 1:1 segregation of resistant and susceptible plants inoculated with L. maculans isolate 03-15-03. The results suggest that the
resistance to L. maculans introgressed from synthetic hexaploid Brassica species into B. napus is most likely controlled by a single locus.
Advisors/Committee Members: Genyi Li (Plant Science) (supervisor), Robert Duncan (Plant science) Thomas Booth (Biological sciences) (examiningcommittee).
Subjects/Keywords: blackleg resistance
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APA ·
Chicago ·
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APA (6th Edition):
Wang, D. (2016). Transferring blackleg resistance from Brassica carinata and synthetic hexaploid Brassica accessions into Brassica napus. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/31196
Chicago Manual of Style (16th Edition):
Wang, Duoduo. “Transferring blackleg resistance from Brassica carinata and synthetic hexaploid Brassica accessions into Brassica napus.” 2016. Masters Thesis, University of Manitoba. Accessed March 02, 2021.
http://hdl.handle.net/1993/31196.
MLA Handbook (7th Edition):
Wang, Duoduo. “Transferring blackleg resistance from Brassica carinata and synthetic hexaploid Brassica accessions into Brassica napus.” 2016. Web. 02 Mar 2021.
Vancouver:
Wang D. Transferring blackleg resistance from Brassica carinata and synthetic hexaploid Brassica accessions into Brassica napus. [Internet] [Masters thesis]. University of Manitoba; 2016. [cited 2021 Mar 02].
Available from: http://hdl.handle.net/1993/31196.
Council of Science Editors:
Wang D. Transferring blackleg resistance from Brassica carinata and synthetic hexaploid Brassica accessions into Brassica napus. [Masters Thesis]. University of Manitoba; 2016. Available from: http://hdl.handle.net/1993/31196
10.
García Cazorla, Yolanda.
Inhibition of the conjugative traffic ATPase TrwD by fatty acid derivatives: Inhibición de la ATPasa conjugativa TrwD por derivados de ácidos grasos.
Degree: 2018, Universidad de Cantabria
URL: http://hdl.handle.net/10902/14718
► ABSTRACT: Antibiotic resistance has become a pressing public health concern. The main mechanism for the dissemination of resistance genes is the horizontal transfer during conjugation.…
(more)
▼ ABSTRACT: Antibiotic
resistance has become a pressing public health concern. The main mechanism for the dissemination of
resistance genes is the horizontal transfer during conjugation. Hence, the search for conjugation inhibitors (COINs) is paramount in the fight against the spread of resistances. In this pursuit, only unsaturated fatty acids had been described as COINs. Here, we define 2-bromopalmitic acid (2-BP) as a specific COIN. 2-BP is a palmitate analog without any unsaturation in its aliphatic chain which acts as inhibitor of many membrane-associated enzymes. The carboxylic group of COINs is essential for its effectivity. However, inhibition is not due to the presence of double or triple bonds in these compounds but, indirectly, by the conformation COINs can acquire upon binding to their molecular target.
We identify the VirB11 homolog in the conjugative plasmid R388, the traffic ATPase TrwD, as their molecular target. VirB11 form hexameric rings in which each monomer has a C-terminal catalytic region (CTD) and a N-terminal region that interacts with the cytoplasmic site of the membrane (NTD) connected both of them by a flexible linker. Biochemical and structural characterizations define a non-competitive inhibition where COINs bind to a pocket comprised by NTD and linker, preventing the pivoting movement of NTD over CTD which, in turn, result in a reduction of TrwD ATPase activity. Interestingly, COINs are liberally incorporated into bacterial membranes, replacing palmitic acid as the major component. We determine that TrwD binds palmitic acid, thus facilitating its interaction with the membrane. Altogether, our data suggest that COINs bind TrwD at a site that is otherwise occupied by palmitic acid, albeit they differ in the contacts involved in the interaction. As a result, COINs affect the interaction of TrwD with the membrane.
For a further understand of the conjugative process, we visualized the process in real time using fluorescent protein fusions to the main players in the conjugative system. Localization of the proteins suffers dramatic changes in the presence or absence of the rest of the component of the Type IV secretion system (T4SS). Moreover, by using fluorescent constructs of SeqA, a probe that binds hemimethylated DNA, we have found, surprisingly, that more than one event of conjugation takes place at a particular time. Additionally, we identify the formation of a weak complex between TrwD and the relaxase TrwC. TrwD presents structural homology to chaperones of the ClpB/Hsp 104 family, hence TrwD could play a chaperone activity during the transport of the pilot protein TrwC.
In short, our results do not only contribute to a better understanding of VirB11 proteins and the conjugative process but also may open a new avenue for the rational design of more potent and effective drugs to control dissemination of antibiotic
resistance genes.
Advisors/Committee Members: Cabezón Navarro, María Elena (advisor), Universidad de Cantabria (other).
Subjects/Keywords: Antibiotic resistance
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
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APA (6th Edition):
García Cazorla, Y. (2018). Inhibition of the conjugative traffic ATPase TrwD by fatty acid derivatives: Inhibición de la ATPasa conjugativa TrwD por derivados de ácidos grasos. (Doctoral Dissertation). Universidad de Cantabria. Retrieved from http://hdl.handle.net/10902/14718
Chicago Manual of Style (16th Edition):
García Cazorla, Yolanda. “Inhibition of the conjugative traffic ATPase TrwD by fatty acid derivatives: Inhibición de la ATPasa conjugativa TrwD por derivados de ácidos grasos.” 2018. Doctoral Dissertation, Universidad de Cantabria. Accessed March 02, 2021.
http://hdl.handle.net/10902/14718.
MLA Handbook (7th Edition):
García Cazorla, Yolanda. “Inhibition of the conjugative traffic ATPase TrwD by fatty acid derivatives: Inhibición de la ATPasa conjugativa TrwD por derivados de ácidos grasos.” 2018. Web. 02 Mar 2021.
Vancouver:
García Cazorla Y. Inhibition of the conjugative traffic ATPase TrwD by fatty acid derivatives: Inhibición de la ATPasa conjugativa TrwD por derivados de ácidos grasos. [Internet] [Doctoral dissertation]. Universidad de Cantabria; 2018. [cited 2021 Mar 02].
Available from: http://hdl.handle.net/10902/14718.
Council of Science Editors:
García Cazorla Y. Inhibition of the conjugative traffic ATPase TrwD by fatty acid derivatives: Inhibición de la ATPasa conjugativa TrwD por derivados de ácidos grasos. [Doctoral Dissertation]. Universidad de Cantabria; 2018. Available from: http://hdl.handle.net/10902/14718

University of Florida
11.
Yuan, Weimin.
Evaluation of Resistance to Meloidogyne Arenaria in the Peanut (Arachis Hypogaea. L) Cv. Tifguard.
Degree: PhD, Entomology and Nematology, 2017, University of Florida
URL: https://ufdc.ufl.edu/UFE0050637
► Tifguard, which was released as a peanut cultivar resistant to root-knot nematode and tomato spotted wilt virus in 2007, was found to be heavily infected…
(more)
▼ Tifguard, which was released as a peanut cultivar resistant to root-knot nematode and tomato spotted wilt virus in 2007, was found to be heavily infected by Meloidogyne arenaria in several peanut production fields in Florida in 2012. The goal of this project was to determine why the cultivar that was reported to be highly resistant succumbed to root-knot nematode infection. The objectives were to evaluate the
resistance of three different sources of Tifguard seeds; to determine the seasonal population changes and vertical population densities of M. arenaria collected from resistant and susceptible peanut rhizospheres in two different soil types; to determine the effects of high temperature on the
resistance in Tifguard, and to compare the yield of Tifguard, isogenic Tifguard and Georgia-06G treated vs. nontreated with 1,3-dichloropropene. In three M. arenaria infested field sites, a comparison of Tifguard seed obtained from three sources showed that 2.5, 28, and 39.5% of plants that were infected by the nematode were negative for the nematode
resistance gene. The seasonal distribution of second-stage juvenile (J2) of M. arenaria followed similar trends in two different soil types, with a peak occurring during late summer and early fall at harvest. Number of J2 dropped following harvest and reached a density less than 10 J2/200 cm3 of soil in February. Comparison of vertical population densities of J2 collected from Georgia-06G rhizosphere in two different soil types showed that greater numbers occurred in the upper 60 cm of soil during the growing season in a Candler sand, whereas in a Norfolk loamy sand greater densities were found only in the top 45 cm. The population densities of J2 collected from Georgia-06G rhizosphere at all depths were much greater in Norfolk loamy sand than that in the Candler sand. Tifguard reduced the nematode population to 1 and 28 in the Candler sand and the Norfolk loamy sand, respectively at harvest. Comparison of nematode numbers from different developmental stages at different temperatures demonstrated that the high soil temperature increased nematode infection rate and accelerated nematode development in Georgia-06G. No further development of J2 occurred in Tifguard roots at 28 or 31 C, however at 34 C a few J3-J4, females, egg laying females, and males of M. arenaria were observed. Comparisons indicated that there was no effect of 1,3-dichloropropene on root-knot nematode damage and yield of Georgia-06G, Tifguard, or isogenic Tifguard. ( en )
Advisors/Committee Members: DICKSON,DONALD W (committee chair), BRITO,JANETE A (committee member), PRESTON,JAMES F,III (committee member).
Subjects/Keywords: resistance – tifguard
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Yuan, W. (2017). Evaluation of Resistance to Meloidogyne Arenaria in the Peanut (Arachis Hypogaea. L) Cv. Tifguard. (Doctoral Dissertation). University of Florida. Retrieved from https://ufdc.ufl.edu/UFE0050637
Chicago Manual of Style (16th Edition):
Yuan, Weimin. “Evaluation of Resistance to Meloidogyne Arenaria in the Peanut (Arachis Hypogaea. L) Cv. Tifguard.” 2017. Doctoral Dissertation, University of Florida. Accessed March 02, 2021.
https://ufdc.ufl.edu/UFE0050637.
MLA Handbook (7th Edition):
Yuan, Weimin. “Evaluation of Resistance to Meloidogyne Arenaria in the Peanut (Arachis Hypogaea. L) Cv. Tifguard.” 2017. Web. 02 Mar 2021.
Vancouver:
Yuan W. Evaluation of Resistance to Meloidogyne Arenaria in the Peanut (Arachis Hypogaea. L) Cv. Tifguard. [Internet] [Doctoral dissertation]. University of Florida; 2017. [cited 2021 Mar 02].
Available from: https://ufdc.ufl.edu/UFE0050637.
Council of Science Editors:
Yuan W. Evaluation of Resistance to Meloidogyne Arenaria in the Peanut (Arachis Hypogaea. L) Cv. Tifguard. [Doctoral Dissertation]. University of Florida; 2017. Available from: https://ufdc.ufl.edu/UFE0050637

University of Ottawa
12.
Laskey, Alexander.
Horizontal Transfer of β-Lactam Resistance in the Mouse Gut Microbiota Under Antibiotic Treatment.
Degree: MSc, Médecine / Medicine, 2020, University of Ottawa
URL: http://dx.doi.org/10.20381/ruor-25628
► The rise of β-lactam-resistant bacteria from agricultural settings, including food-producing animals and their related food products has become a significant public health concern. Consumption of…
(more)
▼ The rise of β-lactam-resistant bacteria from agricultural settings, including food-producing animals and their related food products has become a significant public health concern. Consumption of food contaminated by such bacteria may cause infection as well as the transmission of
resistance genes. Here we used a mouse model to assess the impact of different antibiotic treatments on the composition of the gut microbiota and any impact on the transfer of β-lactam
resistance genes between donor and recipient bacteria. Mice were inoculated with β-lactam resistant Escherichia coli and an antibiotic-susceptible Salmonella Heidelberg strain. The mice were treated with either streptomycin, ampicillin or both antibiotics. Mouse feces were collected at regular intervals and processed using selective culture techniques to capture potential transfer of
resistance genes. Gene transfer was confirmed by whole genome sequencing. DNA extracted from the feces was used for monitoring changes in microbial profiles by 16S rDNA sequencing. In the absence of antibiotic treatment, the inoculated bacteria were only transiently detected and no transconjugants were recovered from the mouse feces. In comparison, antibiotic treatment changed microbial profiles in the mouse gut, enhanced colonization of the bacterial isolates, and facilitated the transfer of the
resistance genes into both S. Heidelberg and commensal E. coli recipient strains. The results of this study indicated that the use of multiple antibiotics may enhance infection of opportunistic β-lactam resistant bacterial pathogens relative to single antibiotics and pose a greater risk in terms of antibiotic
resistance gene transfer. Such process might occur in clinical settings where patients are under prolonged antibiotic treatments. Information gained through this study together with future work will inform the development of new policies guiding the prudent use of antibiotics.
Advisors/Committee Members: Lin, Min (supervisor), Wang, Lisheng (supervisor).
Subjects/Keywords: Antimicrobial Resistance
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MLA ·
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CSE |
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APA (6th Edition):
Laskey, A. (2020). Horizontal Transfer of β-Lactam Resistance in the Mouse Gut Microbiota Under Antibiotic Treatment. (Masters Thesis). University of Ottawa. Retrieved from http://dx.doi.org/10.20381/ruor-25628
Chicago Manual of Style (16th Edition):
Laskey, Alexander. “Horizontal Transfer of β-Lactam Resistance in the Mouse Gut Microbiota Under Antibiotic Treatment.” 2020. Masters Thesis, University of Ottawa. Accessed March 02, 2021.
http://dx.doi.org/10.20381/ruor-25628.
MLA Handbook (7th Edition):
Laskey, Alexander. “Horizontal Transfer of β-Lactam Resistance in the Mouse Gut Microbiota Under Antibiotic Treatment.” 2020. Web. 02 Mar 2021.
Vancouver:
Laskey A. Horizontal Transfer of β-Lactam Resistance in the Mouse Gut Microbiota Under Antibiotic Treatment. [Internet] [Masters thesis]. University of Ottawa; 2020. [cited 2021 Mar 02].
Available from: http://dx.doi.org/10.20381/ruor-25628.
Council of Science Editors:
Laskey A. Horizontal Transfer of β-Lactam Resistance in the Mouse Gut Microbiota Under Antibiotic Treatment. [Masters Thesis]. University of Ottawa; 2020. Available from: http://dx.doi.org/10.20381/ruor-25628

University of Canterbury
13.
Pilgrim, Michael.
The impact of differential friction on curve negotiation speed.
Degree: Master of Engineering in Transportation, Transportation Engineering, 2014, University of Canterbury
URL: http://dx.doi.org/10.26021/3450
► This thesis considers the impact of differential skid resistance between wheel paths on the speed at which a vehicle can safely negotiate a curve. Currently…
(more)
▼ This thesis considers the impact of differential skid resistance between wheel paths on the speed at
which a vehicle can safely negotiate a curve. Currently the New Zealand Transport Agency undertakes
measurement of the co-efficient of friction on the state highway network by measuring both wheel
paths, but taking the average value to represent the level of skid resistance available. Part of the basis
for this approach is that modern cars have Electronic Stability Control that has historically been
considered to negate the effects of any differential friction.
Aside from straight line braking testing, little research has been done on the impacts of differential
friction on curves. There are however a number of areas of research that can be related to this topic.By PC Crash simulation modeling, this research identifies that there are a number of gaps in our understanding of the relationship between vehicles maneuvering on a curve and the effect of varying skid resistance.
It concludes that taking the average of the two values is not the same as considering them separately and, that as the difference in the co-efficient of friction between the wheel paths increases, the speed at which a vehicle can safely maneuver around a curve decreases. It has also been found that when Electronic Stability Control is used the speed at which the vehicle can safely maneuver around a curve decreases further.
Subjects/Keywords: skid resistance
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APA ·
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Export
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APA (6th Edition):
Pilgrim, M. (2014). The impact of differential friction on curve negotiation speed. (Masters Thesis). University of Canterbury. Retrieved from http://dx.doi.org/10.26021/3450
Chicago Manual of Style (16th Edition):
Pilgrim, Michael. “The impact of differential friction on curve negotiation speed.” 2014. Masters Thesis, University of Canterbury. Accessed March 02, 2021.
http://dx.doi.org/10.26021/3450.
MLA Handbook (7th Edition):
Pilgrim, Michael. “The impact of differential friction on curve negotiation speed.” 2014. Web. 02 Mar 2021.
Vancouver:
Pilgrim M. The impact of differential friction on curve negotiation speed. [Internet] [Masters thesis]. University of Canterbury; 2014. [cited 2021 Mar 02].
Available from: http://dx.doi.org/10.26021/3450.
Council of Science Editors:
Pilgrim M. The impact of differential friction on curve negotiation speed. [Masters Thesis]. University of Canterbury; 2014. Available from: http://dx.doi.org/10.26021/3450

Colorado State University
14.
Rovira Sanz, Pablo.
Impact of antibiotic use on resistance in beef feedlot and dairy cattle.
Degree: PhD, Animal Sciences, 2017, Colorado State University
URL: http://hdl.handle.net/10217/183928
► In recent years, consumer demand for natural and organic foods has increased, partly due to concerns about the use of antimicrobials in food producing animals.…
(more)
▼ In recent years, consumer demand for natural and organic foods has increased, partly due to concerns about the use of antimicrobials in food producing animals. The aim of this study was to evaluate antimicrobial
resistance (AMR) in beef feedlot and dairy cattle raised without use of antibiotics compared to cattle raised in conventional (CONV) production. Three research projects were conducted to accomplish that general goal. In the first study, a conventional feedlot, natural feedlot, conventional dairy and organic dairy were visited to collect cattle feces, wastewater from lagoons and soil where the wastewater was applied. After DNA extraction, sequencing, and processing, metagenomic reads were aligned to reference databases for identification of antibiotic
resistance genes (ARGs; i.e. the resistome) and bacteria (microbiome). Resistome composition was influenced by rearing method, cattle type, and type of sample. Most mechanisms of
resistance affected by rearing method were enriched (P < 0.05) in conventional samples. Resistome differences were greatest for wastewater samples by rearing method but with contradictory results that suggested an impact of effluent management on wastewater resistome.
Resistance to tetracycline and macrolide-lincosamide-streptogramin classes were more abundant in feces of feedlot cattle than in dairy cattle (P < 0.05); whereas
resistance to beta-lactams was greatest in feces of dairy cattle (P < 0.05). Resistome and microbiome of feces differed (P < 0.05) between wastewater and soil samples. Results indicated that ARGs are widespread in beef feedlot and dairy cattle farms even in those with restricted antibiotic use. In the second study, feces from RWA (n=36) and CONV (n=36) cattle lots were recovered from colons at a commercial beef processing plant. Samples were equally distributed by month and production protocol over one year (3 samples/production protocol/month). After extracting DNA from individual samples, composite samples were prepared by mixing DNA from each lot into a single composite sample (N = 72) and sequencing the composites on an Illumina platform. Metagenomic reads were processed similarly to those in experiment 1for identification of ARGs and bacteria. Resistomes of CONV and RWA cattle were significantly different by season. In general, mechanisms conferring
resistance to beta-lactams, tetracyclines, multi-drug and macrolides were more prevalent (P < 0.05) in feces from CONV colons than in RWA colons. In the third study, a systematic review and meta-analysis was performed to assess the relationship between antimicrobial use (AMU) and antimicrobial
resistance (AMR) in feedlot cattle. After conducting a literature search and screening reported studies, 32 studies were selected for use that addressed AMR in Escherichia coli, Enterococcus, Salmonella, Campylobacter, and Mannheimia haemolytica. Overall, 60% (95% CI: 26% to 88%) of the observational studies and 50% (95% CI: 30% to 70%) of the controlled trials reported a positive association between AMU and AMR.…
Advisors/Committee Members: Belk, Keith (advisor), Morley, Paul (committee member), Schmidt, John (committee member), Yang, Hua (committee member).
Subjects/Keywords: bacteria; metagenomics; antimicrobial resistance; resistance genes; cattle
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
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APA (6th Edition):
Rovira Sanz, P. (2017). Impact of antibiotic use on resistance in beef feedlot and dairy cattle. (Doctoral Dissertation). Colorado State University. Retrieved from http://hdl.handle.net/10217/183928
Chicago Manual of Style (16th Edition):
Rovira Sanz, Pablo. “Impact of antibiotic use on resistance in beef feedlot and dairy cattle.” 2017. Doctoral Dissertation, Colorado State University. Accessed March 02, 2021.
http://hdl.handle.net/10217/183928.
MLA Handbook (7th Edition):
Rovira Sanz, Pablo. “Impact of antibiotic use on resistance in beef feedlot and dairy cattle.” 2017. Web. 02 Mar 2021.
Vancouver:
Rovira Sanz P. Impact of antibiotic use on resistance in beef feedlot and dairy cattle. [Internet] [Doctoral dissertation]. Colorado State University; 2017. [cited 2021 Mar 02].
Available from: http://hdl.handle.net/10217/183928.
Council of Science Editors:
Rovira Sanz P. Impact of antibiotic use on resistance in beef feedlot and dairy cattle. [Doctoral Dissertation]. Colorado State University; 2017. Available from: http://hdl.handle.net/10217/183928
15.
Shawa, Misheck.
Risk factors and Alleles of extended spectrum Beta-Lactamase(ESBL) producing Escherichia coli at the University Teaching Hospital, Zambia.
Degree: 2015, University of Zimbabwe
URL: http://dspace.unza.zm/handle/123456789/4464
► The limitation of antibacterial treatment options imposed by the emergence of bacterial resistant organisms calls for the correct identification of the genes involved in mediating…
(more)
▼ The limitation of antibacterial treatment options imposed by the emergence of bacterial resistant organisms calls for the correct identification of the genes involved in mediating resistance. In this study, antimicrobial resistance was determined in terms of the presence of extended-spectrum beta-lactamases (ESBL) among Escherichia coli isolates obtained from patients admitted at the University Teaching Hospital (UTH) in Zambia. A total of 400 rectal swabs were obtained and subjected to initial screening using MacConkey agar supplemented with cefotaxime. blaTEM, blaSHV and bla CTX-M genes in ESBL producing E. coli were detected using Polymerase Chain Reaction (PCR). All CTX-M positive isolates were subjected to sensitivity patterns using 11 different antibiotics: ampicillin (AMP), trimethoprim-sulphamethoxazole (SXT), streptomycin (STR), tetracycline (TET), gentamycin (GEN), nalidixic acid (NAL), ceftazidime (CAZ), chloramphenicol (CHL), norfloxacin (NOR), ciprofloxacin (CIP) and cefotaxime (CTX).
The prevalence of ESBL producing E. coli was 19% (76/400). Among the ESBL producing E. coli, 25 out of 76 (32.9%) were positive for CTX-M genes. Of the 25 CTX-M positive isolates, 9 (36%) isolates were positive for SHV genes and 9 (36%) were positive for TEM genes. The highest resistance was found to be to nalidixic acid (96%), followed by sulfamethoxazole-trimethoprim, tetracycline and ceftazidime (92% each). The least resistance was to ampicillin (60%). Male gender (p=0.014, 95% CI=1.198-4.813) and history of surgery (p=0.01, 95% CI=1.196-3.740) were found to be significant risk factors for ESBL presence. The findings emphasize that ESBL-producing bacteria are present among patients at the UTH, and that these organisms exhibit co-resistance to several classes of antibiotics.
Subjects/Keywords: Drug resistance, Microbial; Drug resistance in microorganisms
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MLA ·
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CSE |
Export
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APA (6th Edition):
Shawa, M. (2015). Risk factors and Alleles of extended spectrum Beta-Lactamase(ESBL) producing Escherichia coli at the University Teaching Hospital, Zambia. (Thesis). University of Zimbabwe. Retrieved from http://dspace.unza.zm/handle/123456789/4464
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Shawa, Misheck. “Risk factors and Alleles of extended spectrum Beta-Lactamase(ESBL) producing Escherichia coli at the University Teaching Hospital, Zambia.” 2015. Thesis, University of Zimbabwe. Accessed March 02, 2021.
http://dspace.unza.zm/handle/123456789/4464.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Shawa, Misheck. “Risk factors and Alleles of extended spectrum Beta-Lactamase(ESBL) producing Escherichia coli at the University Teaching Hospital, Zambia.” 2015. Web. 02 Mar 2021.
Vancouver:
Shawa M. Risk factors and Alleles of extended spectrum Beta-Lactamase(ESBL) producing Escherichia coli at the University Teaching Hospital, Zambia. [Internet] [Thesis]. University of Zimbabwe; 2015. [cited 2021 Mar 02].
Available from: http://dspace.unza.zm/handle/123456789/4464.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Shawa M. Risk factors and Alleles of extended spectrum Beta-Lactamase(ESBL) producing Escherichia coli at the University Teaching Hospital, Zambia. [Thesis]. University of Zimbabwe; 2015. Available from: http://dspace.unza.zm/handle/123456789/4464
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cambridge
16.
Rowe, Will.
Antimicrobial resistance gene monitoring in aquatic environments.
Degree: PhD, 2016, University of Cambridge
URL: https://www.repository.cam.ac.uk/handle/1810/253755https://www.repository.cam.ac.uk/bitstream/1810/253755/2/license.txt
;
https://www.repository.cam.ac.uk/bitstream/1810/253755/3/license_rdf
;
https://www.repository.cam.ac.uk/bitstream/1810/253755/4/DISSERTATION.corrected.pdf.txt
;
https://www.repository.cam.ac.uk/bitstream/1810/253755/5/DISSERTATION.corrected.pdf.jpg
► This dissertation documents the development of an environmental framework for monitoring antimicrobial resistance gene (ARG) dissemination in the aquatic environment. The work opens with a…
(more)
▼ This dissertation documents the development of an environmental framework for monitoring antimicrobial resistance gene (ARG) dissemination in the aquatic environment. The work opens with a review of the relevant literature and outlines the importance of an environmental framework for monitoring ARG dissemination as part of antimicrobial resistance risk assessments.
The ability to interrogate sequencing data quickly and easily for the presence of ARGs is crucial in order to facilitate their monitoring in the environment. As current laboratory methods for the detection and surveillance of antimicrobial resistant bacteria in the environment were limited in their effectiveness and scope, the dissertation begins by describing the design and implementation of a Search Engine for Antimicrobial Resistance (SEAR), a pipeline and web interface for detection of horizontally-acquired ARGs in raw sequencing data.
The suitability of metagenomic methods for monitoring the ARG content of effluents from faecal sources was then assessed via a pilot study of a river catchment. Novel metagenomes generated from effluents entering the catchment were interrogated for ARGs. The relative abundance of ARGs in effluents were determined to be higher relative to the background environment, as were sequences relating to human and animal pathogens and mobile genetic elements. Thus, effluents were implicated in the dissemination of ARGs throughout the aquatic environment.
To determine if ARGs were potentially in use in the environment, the expression of ARGs within effluents was then evaluated across a series of longitudinal samples through the use of metatranscriptomics, and the presence of potential environmental antimicrobial selection pressures was examined. This demonstrated that the abundance of ARGs, as well as antimicrobial usage at the effluent source, was correlated with the transcription of ARGs in aquatic environments.
The work described in this dissertation has also found that horizontally transmitted ARGs were present in pathogenic endospore-forming bacteria commonly found across the aquatic environment, potentially providing a mechanism for ARG persistence in the environment.
Finally, these findings were integrated into a universal framework for monitoring ARG dissemination in aquatic environments and used to highlight the developments required to incorporate this framework into future environmental ARG research and to facilitate antimicrobial resistance risk assessments.
Subjects/Keywords: Metagenomics; Antimicrobial resistance; Antibiotic resistance; Wastewater
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Rowe, W. (2016). Antimicrobial resistance gene monitoring in aquatic environments. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/253755https://www.repository.cam.ac.uk/bitstream/1810/253755/2/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/253755/3/license_rdf ; https://www.repository.cam.ac.uk/bitstream/1810/253755/4/DISSERTATION.corrected.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/253755/5/DISSERTATION.corrected.pdf.jpg
Chicago Manual of Style (16th Edition):
Rowe, Will. “Antimicrobial resistance gene monitoring in aquatic environments.” 2016. Doctoral Dissertation, University of Cambridge. Accessed March 02, 2021.
https://www.repository.cam.ac.uk/handle/1810/253755https://www.repository.cam.ac.uk/bitstream/1810/253755/2/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/253755/3/license_rdf ; https://www.repository.cam.ac.uk/bitstream/1810/253755/4/DISSERTATION.corrected.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/253755/5/DISSERTATION.corrected.pdf.jpg.
MLA Handbook (7th Edition):
Rowe, Will. “Antimicrobial resistance gene monitoring in aquatic environments.” 2016. Web. 02 Mar 2021.
Vancouver:
Rowe W. Antimicrobial resistance gene monitoring in aquatic environments. [Internet] [Doctoral dissertation]. University of Cambridge; 2016. [cited 2021 Mar 02].
Available from: https://www.repository.cam.ac.uk/handle/1810/253755https://www.repository.cam.ac.uk/bitstream/1810/253755/2/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/253755/3/license_rdf ; https://www.repository.cam.ac.uk/bitstream/1810/253755/4/DISSERTATION.corrected.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/253755/5/DISSERTATION.corrected.pdf.jpg.
Council of Science Editors:
Rowe W. Antimicrobial resistance gene monitoring in aquatic environments. [Doctoral Dissertation]. University of Cambridge; 2016. Available from: https://www.repository.cam.ac.uk/handle/1810/253755https://www.repository.cam.ac.uk/bitstream/1810/253755/2/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/253755/3/license_rdf ; https://www.repository.cam.ac.uk/bitstream/1810/253755/4/DISSERTATION.corrected.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/253755/5/DISSERTATION.corrected.pdf.jpg
17.
Elahi, Mohammad Tariq.
Towards more Effective Censorship Resistance Systems.
Degree: 2015, University of Waterloo
URL: http://hdl.handle.net/10012/9744
► Internet censorship resistance systems (CRSs) have so far been designed in an ad-hoc manner. The fundamentals are unclear and the foundations are shaky. Censors are,…
(more)
▼ Internet censorship resistance systems (CRSs) have so far been designed in an ad-hoc manner. The fundamentals are unclear and the foundations are shaky. Censors are, more and more, able to take advantage of this situation. Future censorship resistance systems ought to be built from strong theoretical underpinnings and be based on empirical evidence.
Our approach is based on systematizing the CRS field and its players. Informed by this systematization we develop frameworks that have broad scope, from which we gain general insight as well as answers to specific questions. We develop theoretical and simulation-based analysis tools 1) for learning how to manipulate censor behavior using game-theoretic tactics, 2) for learning about CRS-client activity levels on CRS networks, and finally 3) for evaluating security parameters in CRS designs.
We learn that there are gaps in the CRS designer's arsenal: certain censor attacks go unmitigated and the dynamics of the censorship arms race are not modeled. Our game-theoretic analysis highlights how managing the base rate of CRS traffic can cause stable equilibriums where the censor allows some amount of CRS communication to occur. We design and deploy a privacy-preserving data gathering tool, and use it to collect statistics to help answer questions about the prevalence of CRS-related traffic in actual CRS communication networks. Finally, our security evaluation of a popular CRS exposes suboptimal settings, which have since been optimized according to our recommendations.
All of these contributions help support the thesis that more formal and empirically driven CRS designs can have better outcomes than the current state of the art.
Subjects/Keywords: Censorship Resistance; Censorship Resistance Systems; Circumvention
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Elahi, M. T. (2015). Towards more Effective Censorship Resistance Systems. (Thesis). University of Waterloo. Retrieved from http://hdl.handle.net/10012/9744
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Elahi, Mohammad Tariq. “Towards more Effective Censorship Resistance Systems.” 2015. Thesis, University of Waterloo. Accessed March 02, 2021.
http://hdl.handle.net/10012/9744.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Elahi, Mohammad Tariq. “Towards more Effective Censorship Resistance Systems.” 2015. Web. 02 Mar 2021.
Vancouver:
Elahi MT. Towards more Effective Censorship Resistance Systems. [Internet] [Thesis]. University of Waterloo; 2015. [cited 2021 Mar 02].
Available from: http://hdl.handle.net/10012/9744.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Elahi MT. Towards more Effective Censorship Resistance Systems. [Thesis]. University of Waterloo; 2015. Available from: http://hdl.handle.net/10012/9744
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cambridge
18.
Rowe, Will.
Antimicrobial resistance gene monitoring in aquatic environments.
Degree: PhD, 2016, University of Cambridge
URL: https://doi.org/10.17863/CAM.16362
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.683707
► This dissertation documents the development of an environmental framework for monitoring antimicrobial resistance gene (ARG) dissemination in the aquatic environment. The work opens with a…
(more)
▼ This dissertation documents the development of an environmental framework for monitoring antimicrobial resistance gene (ARG) dissemination in the aquatic environment. The work opens with a review of the relevant literature and outlines the importance of an environmental framework for monitoring ARG dissemination as part of antimicrobial resistance risk assessments. The ability to interrogate sequencing data quickly and easily for the presence of ARGs is crucial in order to facilitate their monitoring in the environment. As current laboratory methods for the detection and surveillance of antimicrobial resistant bacteria in the environment were limited in their effectiveness and scope, the dissertation begins by describing the design and implementation of a Search Engine for Antimicrobial Resistance (SEAR), a pipeline and web interface for detection of horizontally-acquired ARGs in raw sequencing data. The suitability of metagenomic methods for monitoring the ARG content of effluents from faecal sources was then assessed via a pilot study of a river catchment. Novel metagenomes generated from effluents entering the catchment were interrogated for ARGs. The relative abundance of ARGs in effluents were determined to be higher relative to the background environment, as were sequences relating to human and animal pathogens and mobile genetic elements. Thus, effluents were implicated in the dissemination of ARGs throughout the aquatic environment. To determine if ARGs were potentially in use in the environment, the expression of ARGs within effluents was then evaluated across a series of longitudinal samples through the use of metatranscriptomics, and the presence of potential environmental antimicrobial selection pressures was examined. This demonstrated that the abundance of ARGs, as well as antimicrobial usage at the effluent source, was correlated with the transcription of ARGs in aquatic environments. The work described in this dissertation has also found that horizontally transmitted ARGs were present in pathogenic endospore-forming bacteria commonly found across the aquatic environment, potentially providing a mechanism for ARG persistence in the environment. Finally, these findings were integrated into a universal framework for monitoring ARG dissemination in aquatic environments and used to highlight the developments required to incorporate this framework into future environmental ARG research and to facilitate antimicrobial resistance risk assessments.
Subjects/Keywords: 579; Metagenomics; Antimicrobial resistance; Antibiotic resistance; Wastewater
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Rowe, W. (2016). Antimicrobial resistance gene monitoring in aquatic environments. (Doctoral Dissertation). University of Cambridge. Retrieved from https://doi.org/10.17863/CAM.16362 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.683707
Chicago Manual of Style (16th Edition):
Rowe, Will. “Antimicrobial resistance gene monitoring in aquatic environments.” 2016. Doctoral Dissertation, University of Cambridge. Accessed March 02, 2021.
https://doi.org/10.17863/CAM.16362 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.683707.
MLA Handbook (7th Edition):
Rowe, Will. “Antimicrobial resistance gene monitoring in aquatic environments.” 2016. Web. 02 Mar 2021.
Vancouver:
Rowe W. Antimicrobial resistance gene monitoring in aquatic environments. [Internet] [Doctoral dissertation]. University of Cambridge; 2016. [cited 2021 Mar 02].
Available from: https://doi.org/10.17863/CAM.16362 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.683707.
Council of Science Editors:
Rowe W. Antimicrobial resistance gene monitoring in aquatic environments. [Doctoral Dissertation]. University of Cambridge; 2016. Available from: https://doi.org/10.17863/CAM.16362 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.683707

University of Sydney
19.
Seebacher, Nicole Aveline.
Overcoming the Dual Mechanism of Stress-Induced, Pgp-Mediated Drug Resistance using Novel Thiosemicarbazones
.
Degree: 2015, University of Sydney
URL: http://hdl.handle.net/2123/13847
► Multi-drug resistance (MDR) is the principal mechanism by which many cancers develop resistance to chemotherapy drugs. It is the major factor responsible for the failure…
(more)
▼ Multi-drug resistance (MDR) is the principal mechanism by which many cancers develop resistance to chemotherapy drugs. It is the major factor responsible for the failure of many forms of chemotherapy. P-glycoprotein (Pgp) is the most highly studied ABC transporter involved in the efflux of cytotoxic substances out of the cell. Studies have shown that Pgp expression is up-regulated in tumour cells through the activation of the hypoxia-inducible factor-1 (HIF-1) pathway. Interestingly, this protein is typically up-regulated by conditions of oxidative stress, such as hypoxia and nutrient limitation, and has been measured at elevated levels within tumours. Consequently, the tumour micro-environment may play an important part in regulating MDR. For the first time, the work reported in this thesis reveals underlying cellular pathways involving regulation of both surface and intracellular MDR by the tumour micro-environment. Moreover, the use of novel thiosemicarbazones to overcome MDR is demonstrated as a promising therapeutic strategy in combination with common chemotherapeutic agents that are subject to lysosomal trapping. These findings may help significantly improve the activity of existing chemotherapeutics and help improve patient treatment outcomes with potent thiosemicarbazones, such as Di-2-pyridylketone 4-cyclohexyl, 4-methyl-3-thiosemicarbazone (DpC), that will enter clinical trials in late 2015.
Subjects/Keywords: P-glycoprotein;
Multidrug resistance;
Resistance;
Chemotherapy
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Seebacher, N. A. (2015). Overcoming the Dual Mechanism of Stress-Induced, Pgp-Mediated Drug Resistance using Novel Thiosemicarbazones
. (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/13847
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Seebacher, Nicole Aveline. “Overcoming the Dual Mechanism of Stress-Induced, Pgp-Mediated Drug Resistance using Novel Thiosemicarbazones
.” 2015. Thesis, University of Sydney. Accessed March 02, 2021.
http://hdl.handle.net/2123/13847.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Seebacher, Nicole Aveline. “Overcoming the Dual Mechanism of Stress-Induced, Pgp-Mediated Drug Resistance using Novel Thiosemicarbazones
.” 2015. Web. 02 Mar 2021.
Vancouver:
Seebacher NA. Overcoming the Dual Mechanism of Stress-Induced, Pgp-Mediated Drug Resistance using Novel Thiosemicarbazones
. [Internet] [Thesis]. University of Sydney; 2015. [cited 2021 Mar 02].
Available from: http://hdl.handle.net/2123/13847.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Seebacher NA. Overcoming the Dual Mechanism of Stress-Induced, Pgp-Mediated Drug Resistance using Novel Thiosemicarbazones
. [Thesis]. University of Sydney; 2015. Available from: http://hdl.handle.net/2123/13847
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Mississippi State University
20.
Walker, Ian Daniel.
A THEORY OF MUSIC AS POLITICAL RESISTANCE.
Degree: MA, Political Science and Public Administration, 2012, Mississippi State University
URL: http://sun.library.msstate.edu/ETD-db/theses/available/etd-03082012-171433/
;
► This thesis began as a curiosity about the correlation between politics and music. Closer inspection revealed that there is an absence of literature discussing…
(more)
▼ This thesis began as a curiosity about the correlation between politics and music. Closer inspection revealed that there is an absence of literature discussing the relationship between the two. The vacuum in the literature allows this adaptation of John Kingdons Streams Theory to serve as a theoretical framework through which the relationship between music and politics can be viewed. Upon applying this theoretical framework, the case study genres identified paint a picture of resistant music arising as a function of government action, social climate, and large-scale events that affect the streams identified. In short, government action, social climate, and large-scale events combine at times to augment the streams which can lead to convergences that can lead to the creation of both socially and politically resistant musics. Evidence of the functionality of this theory can be found in case studies of musical genres from the 1950s to the 1990s.
Advisors/Committee Members: Mary McThomas (chair), Dagmar Radin (committee member), P. Edward French (committee member).
Subjects/Keywords: music; political; resistance
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Walker, I. D. (2012). A THEORY OF MUSIC AS POLITICAL RESISTANCE. (Masters Thesis). Mississippi State University. Retrieved from http://sun.library.msstate.edu/ETD-db/theses/available/etd-03082012-171433/ ;
Chicago Manual of Style (16th Edition):
Walker, Ian Daniel. “A THEORY OF MUSIC AS POLITICAL RESISTANCE.” 2012. Masters Thesis, Mississippi State University. Accessed March 02, 2021.
http://sun.library.msstate.edu/ETD-db/theses/available/etd-03082012-171433/ ;.
MLA Handbook (7th Edition):
Walker, Ian Daniel. “A THEORY OF MUSIC AS POLITICAL RESISTANCE.” 2012. Web. 02 Mar 2021.
Vancouver:
Walker ID. A THEORY OF MUSIC AS POLITICAL RESISTANCE. [Internet] [Masters thesis]. Mississippi State University; 2012. [cited 2021 Mar 02].
Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-03082012-171433/ ;.
Council of Science Editors:
Walker ID. A THEORY OF MUSIC AS POLITICAL RESISTANCE. [Masters Thesis]. Mississippi State University; 2012. Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-03082012-171433/ ;

McMaster University
21.
Spanogiannopoulos, Peter.
Exploring Rifamycin Inactivation from the Soil Microbiome.
Degree: PhD, 2014, McMaster University
URL: http://hdl.handle.net/11375/16283
► Our battle against pathogens has become a challenge due to the rise in antibiotic resistance and the dwindling number of new antibiotics entering the clinic.…
(more)
▼ Our battle against pathogens has become a challenge due to the rise in antibiotic resistance and the dwindling number of new antibiotics entering the clinic. Most antibiotics owe their origins to soil bacteria, which have been producing these natural products for millennia. The rifamycins are products of actinomycetes and semisynthetic derivatives of these have been very successful in the clinic. Rifampin (RIF) has been a cornerstone agent against tuberculosis for over 50 years. In the clinic, pathogens typically develop RIF resistance by mutation of the drug. Nonetheless, a number of diverse RIF resistance mechanisms have been described, including enzymatic inactivation.
Environmental bacteria are multidrug resistant, likely due to sharing the same niche as antibiotic producers and represent a reservoir of ancient resistance determinants. Furthermore, these resistance determinants have been linked to pathogens. Exploring the antibiotic resistome, the collection of all antibiotic resistance determinants from the global microbiota, reveals the diversity and evolution of resistance and provides insight on vulnerabilities of our current antibiotics.
Herein, I describe a diverse collection of RIF-inactivating mechanisms from soil actinomycetes. I identified heretofore unknown RIF glycosyltransferase and RIF phosphotransferase genes (rgt and rph, respectively). RGT and RPH enzymes display broad rifamycin specificity and contribute to high-level resistance. Interestingly, RIF-sensitive Gram-positive pathogens are carriers of RPH, highlighting the existence of a ‘silent’ resistome in clinically relevant bacteria and emphasize the importance of studying resistance from environmental bacteria. Furthermore, I identified a conserved upstream DNA motif associated with RIF-inactivating genes from actinomycetes and demonstrate its role in RIF-responsive gene regulation. Finally, I explore the use of a RIF-resistance guided approach to identify novel rifamycin producing bacteria.
This study expands the rifamycin resistome, provides evidence of vulnerabilities of our current arsenal of rifamycin antibiotics, and offers a strategy to identify new members of this family natural product family.
Thesis
Doctor of Science (PhD)
Advisors/Committee Members: Wright, Gerard D., Biochemistry and Biomedical Sciences.
Subjects/Keywords: Antibiotic resistance; Microbiology
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Spanogiannopoulos, P. (2014). Exploring Rifamycin Inactivation from the Soil Microbiome. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/16283
Chicago Manual of Style (16th Edition):
Spanogiannopoulos, Peter. “Exploring Rifamycin Inactivation from the Soil Microbiome.” 2014. Doctoral Dissertation, McMaster University. Accessed March 02, 2021.
http://hdl.handle.net/11375/16283.
MLA Handbook (7th Edition):
Spanogiannopoulos, Peter. “Exploring Rifamycin Inactivation from the Soil Microbiome.” 2014. Web. 02 Mar 2021.
Vancouver:
Spanogiannopoulos P. Exploring Rifamycin Inactivation from the Soil Microbiome. [Internet] [Doctoral dissertation]. McMaster University; 2014. [cited 2021 Mar 02].
Available from: http://hdl.handle.net/11375/16283.
Council of Science Editors:
Spanogiannopoulos P. Exploring Rifamycin Inactivation from the Soil Microbiome. [Doctoral Dissertation]. McMaster University; 2014. Available from: http://hdl.handle.net/11375/16283

Queens University
22.
Khalifa, Tarek.
The Effects of Elevated Temperatures on Fibre Reinforced Polymers for Strengthening Concrete Structures
.
Degree: Civil Engineering, 2011, Queens University
URL: http://hdl.handle.net/1974/6559
► Fibre reinforced polymer (FRP) materials have been a material of interest in the field of structural engineering due to their superior mechanical properties such as…
(more)
▼ Fibre reinforced polymer (FRP) materials have been a material of interest in the field of structural engineering due to their superior mechanical properties such as high strength to weight ratios and resistance to environmental degradation and corrosion. Even though research has established the material to be a viable option for construction they are highly susceptible to elevated temperatures. There are several systems available on the market and a great deal of research needs to be conducted to investigate the change in properties and different behaviour at elevated temperature to serve as a better basis for design. The main objective of this project and the experimental program presented in this thesis is to study the thermo mechanical properties of the available systems on the market.
A summary of the previous research done in the area covering other materials is presented providing an introduction to the behaviour of different systems under elevated temperature. Then, two different experimental programs are presented. The first considers the glass transition temperature and thermal decomposition of the different systems and the second examines the tensile strength of the different systems under different temperature regimes.
The results of both experimental programs are presented and then a connection between the thermo mechanical properties of the resins and the overall strength of the system is established. The research demonstrates that the glass transition temperature of the resin used for an FRP strengthening system is the main determinant of the performance at high temperatures.
Subjects/Keywords: Fire resistance
;
FRP
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Khalifa, T. (2011). The Effects of Elevated Temperatures on Fibre Reinforced Polymers for Strengthening Concrete Structures
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/6559
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Khalifa, Tarek. “The Effects of Elevated Temperatures on Fibre Reinforced Polymers for Strengthening Concrete Structures
.” 2011. Thesis, Queens University. Accessed March 02, 2021.
http://hdl.handle.net/1974/6559.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Khalifa, Tarek. “The Effects of Elevated Temperatures on Fibre Reinforced Polymers for Strengthening Concrete Structures
.” 2011. Web. 02 Mar 2021.
Vancouver:
Khalifa T. The Effects of Elevated Temperatures on Fibre Reinforced Polymers for Strengthening Concrete Structures
. [Internet] [Thesis]. Queens University; 2011. [cited 2021 Mar 02].
Available from: http://hdl.handle.net/1974/6559.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Khalifa T. The Effects of Elevated Temperatures on Fibre Reinforced Polymers for Strengthening Concrete Structures
. [Thesis]. Queens University; 2011. Available from: http://hdl.handle.net/1974/6559
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Stellenbosch University
23.
Fouche, Desire.
Drug-drug interactions between antiretrovirals and fluconazole in HIV-infected patients.
Degree: MScMedSc, Medicine, 2012, Stellenbosch University
URL: http://hdl.handle.net/10019.1/20079
► ENGLISH ABSTRACT: Background: HIV-positive patients have a significantly weakened immune system which makes them highly susceptible for opportunistic infections, requiring additional treatment. Cryptococcal meningitis and…
(more)
▼ ENGLISH ABSTRACT: Background: HIV-positive patients have a significantly weakened immune system which
makes them highly susceptible for opportunistic infections, requiring additional treatment.
Cryptococcal meningitis and oropharyngeal candidiasis are treated with oral fluconazole. A
great potential for drug-drug interactions (DDIs) between fluconazole and antiretrovirals
(ARVs), efavirenz, nevirapine, and lopinavir/ritonavir, exists due to interference in common
metabolic pathways. The outcome may result in the development of adverse drug reactions
or drug
resistance and treatment failure.
Aim: The primary aim of this thesis was to evaluate the effect of fluconazole on the
pharmacokinetics of efavirenz, nevirapine and lopinavir/ritonavir in HIV-infected patients
diagnosed with cryptococcal meningitis or oropharyngeal candidiasis.
Methods: A prospective study was conducted in 80 HIV-positive, treatment experienced
adults (≥18 years old) treated in three different outpatient clinics in the Western Cape region.
Patients were subdivided according to ARV regimen and the use of fluconazole. A sparse
sampling design was used and corresponding ARV serum concentrations were determined by
established HPLC and GC methods. Fluconazole serum concentrations were determined by a
newly developed HPLC method. Patient characteristics, concomitant medications, clinical
test data and ARV serum concentrations were included in a NONMEM generated, onecompartment,
open pharmacometric model with first order elimination to detect any drugdrug
interactions between fluconazole and the studied ARVs. The secondary outcome was to
establish which patient characteristics influence ARV pharmacokinetics.
Results: From 80 outpatients, a total of 276 ARV serum samples (137 efavirenz, 67
nevirapine and 72 lopinavir) were collected for pharmacokinetic evaluation. Efavirenz
clearance was correlated with race and concomitant use of rifampicin. No significant
covariates were established in the nevirapine model. In the lopinavir model, concomitant use
of clotrimazole and the antituberculosis combination isoniazid, pyrazinamide and rifampicin
were identified as significant covariates.
Discussion: No significant effects of fluconazole on the pharmacokinetics of any of the
studied ARVs were observed. Varying efavirenz plasma concentrations in different ethnic
populations may be due to differences in gene expression particularly CYP2B6. Coloured patients had significantly lower efavirenz serum concentrations (56.8% decrease in
clearance), which has not been previously described in the South African context. Although
gender was not a significant covariate in the nevirapine model, female patients tended to have
higher nevirapine serum concentrations. TB treatment in all patients receiving lopinavir
consisted of a combination of isoniazid, pyrazinamide and rifampicin, each with different
effects on CYP isoenzymes. The exact contributing factor of each drug in the ultimate
decrease in lopinavir clearance (46.4%) can therefore not…
Advisors/Committee Members: Rosenkranz, Bernd, Stellenbosch University. Faculty of Health Sciences. Dept. of Medicine. Pharmacology..
Subjects/Keywords: Pharmacology; Drug resistance
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MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Fouche, D. (2012). Drug-drug interactions between antiretrovirals and fluconazole in HIV-infected patients. (Masters Thesis). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/20079
Chicago Manual of Style (16th Edition):
Fouche, Desire. “Drug-drug interactions between antiretrovirals and fluconazole in HIV-infected patients.” 2012. Masters Thesis, Stellenbosch University. Accessed March 02, 2021.
http://hdl.handle.net/10019.1/20079.
MLA Handbook (7th Edition):
Fouche, Desire. “Drug-drug interactions between antiretrovirals and fluconazole in HIV-infected patients.” 2012. Web. 02 Mar 2021.
Vancouver:
Fouche D. Drug-drug interactions between antiretrovirals and fluconazole in HIV-infected patients. [Internet] [Masters thesis]. Stellenbosch University; 2012. [cited 2021 Mar 02].
Available from: http://hdl.handle.net/10019.1/20079.
Council of Science Editors:
Fouche D. Drug-drug interactions between antiretrovirals and fluconazole in HIV-infected patients. [Masters Thesis]. Stellenbosch University; 2012. Available from: http://hdl.handle.net/10019.1/20079

University of Saskatchewan
24.
Denton, Alyssa.
CHARACTERIZING DRUG-RESISTANCE IN ADULTS WITH NEW-ONSET EPILEPSY.
Degree: 2020, University of Saskatchewan
URL: http://hdl.handle.net/10388/12955
► Background and objectives: There are very few studies reporting the factors involved in or the rate of drug-resistant epilepsy (DRE) in adults with new-onset epilepsy…
(more)
▼ Background and objectives: There are very few studies reporting the factors involved in or the rate of drug-resistant epilepsy (DRE) in adults with new-onset epilepsy (NOE). This prospective cohort study characterizes DRE and risk factors in a pure adult cohort with NOE or newly diagnosed epilepsy (NDE). There are very few studies reporting the factors involved in or the rate of DRE in adults with NO and NDE. Methods: Patients were selected from a prospective cohort followed between 2011 and 2018 from the Single Seizure Clinic (SSC) in Saskatoon, SK. The SSC sees patients who experience their first seizure and approximately 30% are diagnosed with epilepsy. We identified the following variables and outcomes in the cohort: age, gender, epilepsy type, seizure onset, etiology, epilepsy syndromes, EEG and imaging outcomes, and the rates of DRE. Inclusion criteria included patients with NO and NDE, age 18 years or older at time of diagnosis, and a minimum 1 year of follow‐up. Results: Ninety-five patients were included, 46 females and 49 males. Median age of onset was 33 years. Of those, 20.0% developed DRE between 2011-2018. Average time between onset and DRE diagnosis was 2.32 years. Bivariate analysis identified age, gender, and etiology as important risk factors for DRE, however these variables failed to be significant in the multivariate model. Discussion: A lower percentage of DRE was identified in this cohort of adults compared to any other published study at present. The majority of patients to develop DRE were diagnosed in the first year of follow up, showing the importance of early characterization and treatment. Similarly, a younger age of onset was shown to be a substantial indicator of the prognosis. Despite a small cohort and insignificant statistical outcomes, our findings might guide the directions of future research in this topic. Significance: The specificity of the cohort along with the outcomes identified in this study contribute valuable information about NOE in adults and the development of DRE. This study has laid the groundwork for not only a larger cohort study to be implemented in the future, but also several other studies to evaluate potential predictors such as specific imaging results as a risk factor for DRE and quality of life assessment through follow-up related to DRE risk.
Advisors/Committee Members: Tellez-Zenteno, Jose, Pena-Sanchez, Juan-Nicolas, Kirk, Andrew, Thorpe, Lilian, Camfield, Peter.
Subjects/Keywords: epilepsy; drug-resistance
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Denton, A. (2020). CHARACTERIZING DRUG-RESISTANCE IN ADULTS WITH NEW-ONSET EPILEPSY. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/12955
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Denton, Alyssa. “CHARACTERIZING DRUG-RESISTANCE IN ADULTS WITH NEW-ONSET EPILEPSY.” 2020. Thesis, University of Saskatchewan. Accessed March 02, 2021.
http://hdl.handle.net/10388/12955.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Denton, Alyssa. “CHARACTERIZING DRUG-RESISTANCE IN ADULTS WITH NEW-ONSET EPILEPSY.” 2020. Web. 02 Mar 2021.
Vancouver:
Denton A. CHARACTERIZING DRUG-RESISTANCE IN ADULTS WITH NEW-ONSET EPILEPSY. [Internet] [Thesis]. University of Saskatchewan; 2020. [cited 2021 Mar 02].
Available from: http://hdl.handle.net/10388/12955.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Denton A. CHARACTERIZING DRUG-RESISTANCE IN ADULTS WITH NEW-ONSET EPILEPSY. [Thesis]. University of Saskatchewan; 2020. Available from: http://hdl.handle.net/10388/12955
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Univerzitet u Beogradu
25.
Aksentijević, Ksenija, 1978-.
Ispitivanje rezistencije na antibiotike kod sojeva
bakterija izolovanih od riba poreklom iz različitih
sredina.
Degree: Fakultet veterinarske medicine, 2017, Univerzitet u Beogradu
URL: https://fedorabg.bg.ac.rs/fedora/get/o:14585/bdef:Content/get
► Preventivna veterinarska medicina - Bolesti riba, Mikrobiologija; Rezistencija bakterija / Preventive veterinary medicine - Fish diseases, Microbiology, Bacterial resistance to
U ovom ispitivanju vršeno je…
(more)
▼ Preventivna veterinarska medicina - Bolesti riba,
Mikrobiologija; Rezistencija bakterija / Preventive veterinary
medicine - Fish diseases, Microbiology, Bacterial resistance
to
U ovom ispitivanju vršeno je uzorkovanje briseva
poreklom od klinički zdravih riba koje su poticale iz različitih
sredina (ribnjaci, akvarijumi, riblje pijace). Izvršena je
izolacija bakterija koje su sastavni deo mikrobioma kože, škrga i
creva riba i ispitivana je osetljivost ovih bakterija na određeni
broj antibiotika koji se koriste u veterinarskoj i humanoj
medicinskoj praksi. Precizna identifikacija ispitivanih sojeva
bakterija vršena je primenom metoda PCR, sekvenciranje gena za 16S
rRNK, MALDI-TOF. Primenom disk difuzionog testa i E testa
ispitivano je fenotipsko ispoljavanje rezistencije na karbapeneme,
ureidopeniciline sa i bez inhibitora betalaktamaza, cefalospirine
III i IV generacije, aminoglikozide, tetraciklin, kolistin,
flurohinolone i hloramfenikol. Prisustvo gena rezistencije, njihova
lokalizacija (na hromozomu ili na mobilnim genetičkim elementima)
vršena je primenom metode PCR. Kod sojeva koji su ispoljili
rezistenciju na nabrojane antibiotike traženi su plazmidi i
ispitivana je konjugabilnost izolovanih plazmida. Posmatrano na
ukupan broj ispitanih sojeva u ovom istraživanju, bez obzira na rod
i vrstu bakterija, ukupno je nađeno 55% sojeva koji su bili
osetljivi na sve antibiotike, kod 22,8% sojeva nađena je
rezistencija na 3 do 16 antibiotika uključujući i antibiotike koji
se koriste isključivo kod ljudi (karbapenemi, ureidopenicilini,
cefalosporini III i IV generacije). Ukupno 22,2% sojeva bilo je
rezistentno na 1 do 2 antibiotika, mada je i među tim sojevima bilo
onih koji su bili rezistentni na antibiotike registrovane samo za
upotrebu kod ljudi (ceftazidim, piperacilin). Kod soja A.
hydrophila izolovanom iz akvarijumske ribice gupi potvrđen je
mehanizam rezistencije nalazom gena rmtB koji je bio lokalizovan na
transpozonu Tn1548 smeštenom na konjugabilnom plazmidu koji je po
tipu replikona bio kategorisan u grupu IncL/M. Kod sojeva
Pseudomonas koji su bili rezistentni na karbapeneme,
ureidopeniciline sa i bez inhibitora betalaktamaza, kao i na
cefalosporine III i IV generacije, nisu nađeni geni za,
karbapenemaze, MßL, ESBL, OXA i AmpC beta-laktamaze (KPC, OXA-23,
OXA- 24, OXA-40, OXA-58, VIM, IMP, SPM, GIM, NDM, TEM, SHV,
CTX-M-1, CTXM- 9, OXA-1, OXA-9, AmpC grupni kao i pojedinačni-MOXM,
CITM, ACCM, EBCM, FOXM, DHAM).Na osnovu dobijenih rezultata
primenom E testa, kod 3 soja iz roda Pseudomonas izolovanih od
šarana nađena je rezistencija na kolistin sa dobijenim vrednostima
MIK 4 μg/mL.
Advisors/Committee Members: Mišić, Dušan, 1969-.
Subjects/Keywords: fish; antibiotics; resistance
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Aksentijević, Ksenija, 1. (2017). Ispitivanje rezistencije na antibiotike kod sojeva
bakterija izolovanih od riba poreklom iz različitih
sredina. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:14585/bdef:Content/get
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Aksentijević, Ksenija, 1978-. “Ispitivanje rezistencije na antibiotike kod sojeva
bakterija izolovanih od riba poreklom iz različitih
sredina.” 2017. Thesis, Univerzitet u Beogradu. Accessed March 02, 2021.
https://fedorabg.bg.ac.rs/fedora/get/o:14585/bdef:Content/get.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Aksentijević, Ksenija, 1978-. “Ispitivanje rezistencije na antibiotike kod sojeva
bakterija izolovanih od riba poreklom iz različitih
sredina.” 2017. Web. 02 Mar 2021.
Vancouver:
Aksentijević, Ksenija 1. Ispitivanje rezistencije na antibiotike kod sojeva
bakterija izolovanih od riba poreklom iz različitih
sredina. [Internet] [Thesis]. Univerzitet u Beogradu; 2017. [cited 2021 Mar 02].
Available from: https://fedorabg.bg.ac.rs/fedora/get/o:14585/bdef:Content/get.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Aksentijević, Ksenija 1. Ispitivanje rezistencije na antibiotike kod sojeva
bakterija izolovanih od riba poreklom iz različitih
sredina. [Thesis]. Univerzitet u Beogradu; 2017. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:14585/bdef:Content/get
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Tasmania
26.
St-Pierre, P.
Role of the microvasculature in the development of muscle insulin resistance.
Degree: 2010, University of Tasmania
URL: https://eprints.utas.edu.au/22258/1/whole_St-PierrePhilippe2010_thesis.pdf
► Type 2 diabetes is a disease characterised by a decrease in the sensitivity to insulin. Recently evidence has suggested an involvement of the microvasculature in…
(more)
▼ Type 2 diabetes is a disease characterised by a decrease in the sensitivity to insulin. Recently evidence has suggested an involvement of the microvasculature in the development of type 2 diabetes. Microvascular perfusion is increased by insulin and impairment of this response may contribute to muscle insulin resistance by limiting insulin and glucose delivery to skeletal muscle myocytes. This thesis focuses on the involvement of the microvascular perfusion in the development of insulin resistance.
Two different models were used to assess the impact of the microvascular perfusion on the insulin-mediated glucose disposal. Firstly, 4 weeks of high-fat diet (HFD model) feeding to rats was used as a pre-diabetic model of insulin resistance. Secondly, partial blockage of skeletal muscle microvascular beds with 15 μm diameter latex microspheres (MS model) was used to assess the effect of decreased muscle microvascular perfusion on insulin sensitivity.
In each model, insulin sensitivity was determined during hyperinsulinaemic isoglycaemic clamps in anaesthetized rats. Femoral arterial blood flow (FBF) and microvascular perfusion (assessed by the hindleg metabolism of infused 1-methylxanthine) were measured. Hindleg glucose uptake was determined from arteriovenous difference and FBF and muscle glucose uptake from [(14)C]-2-deoxyglucose uptake.
Insulin-mediated increases in femoral blood flow and glucose uptake were blunted in the HFD rats compared to those on the normal diet, while insulininduced microvascular perfusion was completely abolished. To see whether contraction responses were intact on the HFD, the functional response to electrical stimulation in the HFD rats was explored. The contraction-mediated increase in microvascular perfusion and glucose uptake was unaffected by the HFD.
In the MS model, microsphere occlusion of hindleg muscle microvasculature diminished microvascular perfusion as well as insulin-mediated glucose uptake, thus causing a vascular-derived acute state of insulin resistance. Next, the long-term effect of microsphere occlusion was assessed. Surprisingly, insulin responses following chronic microsphere occlusion were restored by 2 weeks of recovery post-injection. This may be explained by a rapid angiogenic response in occluded muscle vasculature.
Collectively, this thesis demonstrates two key findings that highlight the potential role of the microvasculature in the development of skeletal muscle insulin resistance: (i) that insulin- but not contraction-mediated microvascular responses are impaired in a pre-diabetic model of insulin resistance, and (ii) that acute physical reduction of microvascular flow impairs muscle insulin sensitivity. This furthers our understanding of the aetiology of type 2 diabetes and emphasizes the microvasculature as an interesting therapeutic target for the management of type 2 diabetes.
Subjects/Keywords: Insulin resistance; Diabetes
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
St-Pierre, P. (2010). Role of the microvasculature in the development of muscle insulin resistance. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/22258/1/whole_St-PierrePhilippe2010_thesis.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
St-Pierre, P. “Role of the microvasculature in the development of muscle insulin resistance.” 2010. Thesis, University of Tasmania. Accessed March 02, 2021.
https://eprints.utas.edu.au/22258/1/whole_St-PierrePhilippe2010_thesis.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
St-Pierre, P. “Role of the microvasculature in the development of muscle insulin resistance.” 2010. Web. 02 Mar 2021.
Vancouver:
St-Pierre P. Role of the microvasculature in the development of muscle insulin resistance. [Internet] [Thesis]. University of Tasmania; 2010. [cited 2021 Mar 02].
Available from: https://eprints.utas.edu.au/22258/1/whole_St-PierrePhilippe2010_thesis.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
St-Pierre P. Role of the microvasculature in the development of muscle insulin resistance. [Thesis]. University of Tasmania; 2010. Available from: https://eprints.utas.edu.au/22258/1/whole_St-PierrePhilippe2010_thesis.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
27.
Rashid, Muhammad Mahmudur.
Antibiotic resistance in different ecological niches in Bangladesh.
Degree: Ecology and Environmental Sciences, 2013, Umeå University
URL: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-84193
► The rapid and wide scale environmental spread of multi-drug resistant bacteria is a seriousissue in recent years. Drug resistant bacteria have already occupied different…
(more)
▼ The rapid and wide scale environmental spread of multi-drug resistant bacteria is a seriousissue in recent years. Drug resistant bacteria have already occupied different ecologicalniches in many places, from wilderness to densely populated urban areas. To investigate theecological niches in Bangladesh samples were collected from wild migratory bird speciesOpen Bill Stork (Anastomus oscitans) and from the nearby water sources where these birdsvisited. A total of 76 E. coli isolates from the 170 OBS (Open Bill Stork) fecal samples and8 E. coli isolates from 3 river sources were isolated. Disk diffusion was used for checking thesusceptibility of the isolates against antibiotics that are common in human and veterinarymedicine in Bangladesh. It was found that 28.95%OBS and all water E. coli isolates wereresistant to at least one of the tested antibiotics. Common resistant phenotypes wereAmpicillin, Tetracycline, Aztreonam, Nalidixic Acid and Ciprofloxacin. Multi-drugresistance identified from 2.63%OBS and most of the water isolates. Very fewESBL(Extended Spectrum Beta-Lactamase) producing E. coli were found from OBS,whereas 50% of E. coli water isolates were ESBL producer, with all the ESBL producerspossessing the CTX-M-15 gene. The most concerning aspect of our findings was the presenceof human associated E. coli sequence types in water samples, for example ST156-complex156, ST10-complex10 and ST46. This study concludes the contaminationof environmental niches in Bangladesh by resistant bacteria.
Subjects/Keywords: Antibiotic resistance; Bangladesh
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Rashid, M. M. (2013). Antibiotic resistance in different ecological niches in Bangladesh. (Thesis). Umeå University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-84193
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Rashid, Muhammad Mahmudur. “Antibiotic resistance in different ecological niches in Bangladesh.” 2013. Thesis, Umeå University. Accessed March 02, 2021.
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-84193.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Rashid, Muhammad Mahmudur. “Antibiotic resistance in different ecological niches in Bangladesh.” 2013. Web. 02 Mar 2021.
Vancouver:
Rashid MM. Antibiotic resistance in different ecological niches in Bangladesh. [Internet] [Thesis]. Umeå University; 2013. [cited 2021 Mar 02].
Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-84193.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Rashid MM. Antibiotic resistance in different ecological niches in Bangladesh. [Thesis]. Umeå University; 2013. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-84193
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Melbourne
28.
Hardefeldt, Laura Yvonne.
Antimicrobial stewardship in Australian veterinary practices.
Degree: 2017, University of Melbourne
URL: http://hdl.handle.net/11343/198446
► Antimicrobial use by the veterinary profession has been coming under increasing scrutiny by medical, public health and government officials as the threat of antimicrobial resistance…
(more)
▼ Antimicrobial use by the veterinary profession has been coming under increasing scrutiny by medical, public health and government officials as the threat of antimicrobial resistance becomes increasingly clear. The World Health Organisation has described antimicrobial resistance as one of the major public health challenges of our time. It is clear that at least some drug-resistant pathogens have evolved under selective pressure from antimicrobial use in agriculture and may be contributing significantly to resistance in clinical setting. Antimicrobial stewardship is the selection of the most appropriate antimicrobial for a given disease in a given animal, with the aim of reducing the risk of adverse effects in that animal, and reducing the likelihood of developing resistance on an individual level, on a farm level and on a national level. Currently none of the core elements of antimicrobial stewardship are widely available for veterinarians in Australia, and there is very sparse data available on which to base an antimicrobial stewardship program. This research project aims to address this paucity of data. A range of research methods were used to assess detailed antimicrobial use by veterinarians in Australia and the enablers and barriers to antimicrobial stewardship. These included quantitative methods such as surveys and analysis of pet insurance data, and qualitative methods such as interviews and focus groups. While antimicrobials with low importance rating were predominately used in all species, under-dosing and inappropriate timing of antimicrobial therapy were common particularly in horses and cattle. Few veterinary practices in Australia had antimicrobial stewardship policies in place, or were using antimicrobial use guidelines. The key barriers to implementing antimicrobial stewardship programs were a lack of antimicrobial stewardship governance structures, client expectations and competition between practices, the cost of microbiological testing, and a lack of access to education, training and antimicrobial stewardship resources. The enablers were, firstly, concern for the role of veterinary antimicrobial use in development of antimicrobial resistance in humans, secondly , a sense of pride in the service provided, and thirdly , preparedness to change prescribing practices. This research culminated in the development of a proposed antimicrobial stewardship policy and procedure documents, to enable veterinarians to institute antimicrobial stewardship programs that suit their individual practice requirements. However, it is likely that governance changes will be necessary to compel veterinary practice owners to implement antimicrobial stewardship on a large scale.
Subjects/Keywords: antibiotic; antimicrobial resistance
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Hardefeldt, L. Y. (2017). Antimicrobial stewardship in Australian veterinary practices. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/198446
Chicago Manual of Style (16th Edition):
Hardefeldt, Laura Yvonne. “Antimicrobial stewardship in Australian veterinary practices.” 2017. Doctoral Dissertation, University of Melbourne. Accessed March 02, 2021.
http://hdl.handle.net/11343/198446.
MLA Handbook (7th Edition):
Hardefeldt, Laura Yvonne. “Antimicrobial stewardship in Australian veterinary practices.” 2017. Web. 02 Mar 2021.
Vancouver:
Hardefeldt LY. Antimicrobial stewardship in Australian veterinary practices. [Internet] [Doctoral dissertation]. University of Melbourne; 2017. [cited 2021 Mar 02].
Available from: http://hdl.handle.net/11343/198446.
Council of Science Editors:
Hardefeldt LY. Antimicrobial stewardship in Australian veterinary practices. [Doctoral Dissertation]. University of Melbourne; 2017. Available from: http://hdl.handle.net/11343/198446

Louisiana State University
29.
Vives Habeych, Maria Carolina.
Yogurt cultures survive upon exposure to two antimicrobials and Streptococcus thermophilus ST-M5 acquired resistance to both antimicrobials.
Degree: MS, Animal Sciences, 2012, Louisiana State University
URL: etd-04242012-154908
;
https://digitalcommons.lsu.edu/gradschool_theses/789
► Different antimicrobials are added in the manufacturing of dairy products such as flavored yogurts and processed cheese. Potassium Metabisulfite (PM) and Potassium Nitrite (PN) have…
(more)
▼ Different antimicrobials are added in the manufacturing of dairy products such as flavored yogurts and processed cheese. Potassium Metabisulfite (PM) and Potassium Nitrite (PN) have been reported to have antimicrobial effect on pathogenic microorganisms such as Clostridium botulinum and Listeria monocytogenes. Yogurt is known for its health benefits, due to the presence of cultured bacteria. PM and PN are not commonly used in the dairy industry hence it would be interesting to study their influence in yogurt culture bacteria. The objectives of this study were: 1. to elucidate the influence of PM and PN at various concentrations, on the growth of yogurt culture and 2. to determine the possible acquisition of resistance after prior exposure to low doses of these antimicrobials. For the first objective different concentrations of PM and PN (100, 1,000, 10,000, 100,000 and 1,000,000ppm) were separately added to broth previously inoculated with Lactobacillus bulgaricus LB-12 and Streptococcus thermophilus ST-M5. Control samples did not receive any antimicrobial. Growth was determined by plating at 0, 24, 48 and 72 hours of incubation. For the second objective, treatments consisted of separately exposing cultures to 100 and 1,000ppm of both antimicrobials and after 24, 48 and 72 hours, transferring them into 10,000 and 100,000ppm, of both antimicrobials. Growth was measured at 0, 24, 48 and 72 hours of incubation. Data were analyzed using Proc Mixed and Repeated Measures model of the Statistical Analysis System SAS®. Differences of Least Square Means where used to determine significant differences. Neither PM nor PN had an antimicrobial effect on yogurt culture Lactobacillus bulgaricus LB-12 or Streptococcus thermophilus ST-M5. Both antimicrobials at 1,000,000ppm significantly increased counts of Streptococcus thermophilus ST-M5 6 log CFU/mL compared to control. Prior exposure of Streptococcus thermophilus ST-M5 to both antimicrobials at 100 and 1,000ppm for 72 hours showed resistance to 10,000 and 100,000ppm of both PM and PN with a significant increase of 6 log CFU/mL compared to control. Commercial applications of this study would be to incorporate PM and PN in yogurt manufacture for inhibition of spoilage and pathogenic bacteria to ensure good preservation of the product and improved shelf life.
Subjects/Keywords: Antimicrobials; inhibition; resistance
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Vives Habeych, M. C. (2012). Yogurt cultures survive upon exposure to two antimicrobials and Streptococcus thermophilus ST-M5 acquired resistance to both antimicrobials. (Masters Thesis). Louisiana State University. Retrieved from etd-04242012-154908 ; https://digitalcommons.lsu.edu/gradschool_theses/789
Chicago Manual of Style (16th Edition):
Vives Habeych, Maria Carolina. “Yogurt cultures survive upon exposure to two antimicrobials and Streptococcus thermophilus ST-M5 acquired resistance to both antimicrobials.” 2012. Masters Thesis, Louisiana State University. Accessed March 02, 2021.
etd-04242012-154908 ; https://digitalcommons.lsu.edu/gradschool_theses/789.
MLA Handbook (7th Edition):
Vives Habeych, Maria Carolina. “Yogurt cultures survive upon exposure to two antimicrobials and Streptococcus thermophilus ST-M5 acquired resistance to both antimicrobials.” 2012. Web. 02 Mar 2021.
Vancouver:
Vives Habeych MC. Yogurt cultures survive upon exposure to two antimicrobials and Streptococcus thermophilus ST-M5 acquired resistance to both antimicrobials. [Internet] [Masters thesis]. Louisiana State University; 2012. [cited 2021 Mar 02].
Available from: etd-04242012-154908 ; https://digitalcommons.lsu.edu/gradschool_theses/789.
Council of Science Editors:
Vives Habeych MC. Yogurt cultures survive upon exposure to two antimicrobials and Streptococcus thermophilus ST-M5 acquired resistance to both antimicrobials. [Masters Thesis]. Louisiana State University; 2012. Available from: etd-04242012-154908 ; https://digitalcommons.lsu.edu/gradschool_theses/789

Queens University
30.
McClure, Nathan.
Assessing strategies for managing drug resistance in treatment of infectious disease: insights from queueing theory
.
Degree: Biology, 2013, Queens University
URL: http://hdl.handle.net/1974/8099
► Antimicrobials have been instrumental in the treatment of infectious disease: responsible for worldwide infection control and reductions in disease-induced morbidity, and mortality. However, in every…
(more)
▼ Antimicrobials have been instrumental in the treatment of infectious disease: responsible for worldwide infection control and reductions in disease-induced morbidity, and mortality. However, in every case where new chemotherapeutic agents have been introduced, resistance to them has eventually evolved. Principally, the current strategy for dealing with this problem is to invest heavily in drug development, with the hope that new drugs become available before all existing drugs lose their efficacy. Instead of focusing on the ‘development side’ of the problem, another possible strategy is to invest in methods of slowing evolution of resistance.
We use a novel application of queueing theory to demonstrate that, when comparing equivalent changes in drug development versus evolution management, the latter has a much greater effect on ensuring a continued supply of effective antimicrobial agents. Our results therefore call for a reappraisal of the current emphasis on enhancing drug development as a means of managing resistance.
Subjects/Keywords: drug resistance
;
evolution
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APA (6th Edition):
McClure, N. (2013). Assessing strategies for managing drug resistance in treatment of infectious disease: insights from queueing theory
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/8099
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
McClure, Nathan. “Assessing strategies for managing drug resistance in treatment of infectious disease: insights from queueing theory
.” 2013. Thesis, Queens University. Accessed March 02, 2021.
http://hdl.handle.net/1974/8099.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
McClure, Nathan. “Assessing strategies for managing drug resistance in treatment of infectious disease: insights from queueing theory
.” 2013. Web. 02 Mar 2021.
Vancouver:
McClure N. Assessing strategies for managing drug resistance in treatment of infectious disease: insights from queueing theory
. [Internet] [Thesis]. Queens University; 2013. [cited 2021 Mar 02].
Available from: http://hdl.handle.net/1974/8099.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
McClure N. Assessing strategies for managing drug resistance in treatment of infectious disease: insights from queueing theory
. [Thesis]. Queens University; 2013. Available from: http://hdl.handle.net/1974/8099
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
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