subject:(resistance)

University of Tennessee – Knoxville

1. Samuels, Ronita. An Epidemiologic Study of Antimicrobial Resistance.

Degree: 2019, University of Tennessee – Knoxville

URL: https://trace.tennessee.edu/utk_graddiss/5703

► The emergence of antimicrobial resistant bacteria has become a serious public health concern. The use of antimicrobials for prophylaxis make it important to estimate the… (more)

▼ The emergence of antimicrobial resistant bacteria has become a serious public health concern. The use of antimicrobials for prophylaxis make it important to estimate the magnitude of the problem in the animal population. The aim of the second chapter in this study is to investigate the burden and patterns of antimicrobial resistance (AMR) among equine Staphylococcus samples submitted to the University of Kentucky Veterinary Diagnostic Laboratory (UKVDL) from 1993 to 2009. The proportion of resistant isolates by animal breed, species of organism, sample source, and time period were computed. Chi-square and Cochran-Armitage trend tests were used to identify significant associations and temporal trends, respectively. Logistic regression models were used to investigate predictors of AMR and multidrug resistance (MDR).In addition to the problem of antimicrobial resistant bacteria, appropriate usage of antimicrobials is also a global public health concern where opinions regarding appropriate use vary greatly amongst veterinarians. Therefore, the objectives of the third chapter of this study are to investigate the opinions, knowledge and perceptions of veterinarians in Kentucky regarding AMR and antimicrobial prescription practices as well as to identify predictors of their knowledge and opinions. This cross-sectional study uses a 30-question survey questionnaire administered to members of the Kentucky Veterinary Medical Association (KVMA). The proportion of responses to survey questions and 95% confidence intervals were computed. Predictors of improper use of antimicrobials and antimicrobial prescription practices of the respondents as well as their colleagues were investigated using multinomial logistic regression models.The appropriate usage of antimicrobials is also an important topic in developing countries such as South Africa. Thus, the fourth chapter in this study investigates the knowledge, prescription practices and attitudes towards AMR among veterinarians in the City of Tshwane, Metropolitan Municipality. A 30-question survey was administered and the percentages of responses to survey questions and their 95% confidence intervals will be computed. Ordinary logistic models are used to investigate predictors of knowledge of antimicrobial resistance and antimicrobial prescription practices of respondents. Predictors of antimicrobial prescription practices of respondents’ colleagues are identified using multinomial logistic models.

Subjects/Keywords: Antimicrobial Resistance; multidrug resistance; Staphylococcus

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APA (6^th Edition):

Samuels, R. (2019). An Epidemiologic Study of Antimicrobial Resistance. (Doctoral Dissertation). University of Tennessee – Knoxville. Retrieved from https://trace.tennessee.edu/utk_graddiss/5703

Chicago Manual of Style (16^th Edition):

Samuels, Ronita. “An Epidemiologic Study of Antimicrobial Resistance.” 2019. Doctoral Dissertation, University of Tennessee – Knoxville. Accessed March 02, 2021. https://trace.tennessee.edu/utk_graddiss/5703.

MLA Handbook (7^th Edition):

Samuels, Ronita. “An Epidemiologic Study of Antimicrobial Resistance.” 2019. Web. 02 Mar 2021.

Vancouver:

Samuels R. An Epidemiologic Study of Antimicrobial Resistance. [Internet] [Doctoral dissertation]. University of Tennessee – Knoxville; 2019. [cited 2021 Mar 02]. Available from: https://trace.tennessee.edu/utk_graddiss/5703.

Council of Science Editors:

Samuels R. An Epidemiologic Study of Antimicrobial Resistance. [Doctoral Dissertation]. University of Tennessee – Knoxville; 2019. Available from: https://trace.tennessee.edu/utk_graddiss/5703

University of Utah

2. Tidwell, Timothy James. Insulin signaling in the hearts of uncoupling protein three knockout mice on a high fat diet.

Degree: Honors BS;, Biology;, 2009, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1658/rec/651

► INTRODUCTION: People with diabetes are at high risk for cardiovascular disease; which is the major cause of death in diabetics. Current research suggests that excessive… (more)

▼ INTRODUCTION: People with diabetes are at high risk for cardiovascular disease; which is the major cause of death in diabetics. Current research suggests that excessive mitochondrial uncoupling is a potential mechanism for cardiac dysfunction in diabetic patients. Uncoupling protein 3 (UCP3) is an inner mitochondrial membrane protein that reduces the amount of reactive oxygen species (ROS) produced in the mitochondrial matrix by uncoupling the mitochondria. Mice lacking UCP3 (UCP3KO) have been shown to accumulate ROS and diacylglycerol in cardiac muscle. These two molecules have been shown to induce insulin resistance in skeletal muscle. The goal of my project was to determine if the absence of UCP3 in the heart will exacerbate diet-induced insulin resistance in the murine heart. MATERIALS AND METHODS: Whole heart homogenates were extracted from four groups of mice: (1) wild type (WT) fed normal chow (NC); (2) WT fed a high fat diet for 10 weeks (HF); (3) UCP3KO NC and (4) UCP3KO HF. Insulin signaling was examined using western-blotting to assess the phosphorylation status of key components of the insulin signaling pathway under non insulin and insulin-stimulated conditions in each group. Values form each group were analyzed using an ANOVA followed by a t test to determine any statistical significant differences between the groups. RESULTS: Phosphorylation of protein kinase B (Akt) (at serine 473 or threonine 308) and the downstream target glycogen synthase kinase 3 p at serine 9 was the same between all the groups. CONCLUSIONS: two major conclusions arise from this work; ( 1 ) 1 0 weeks of high fat diet does not affect insulin signaling in the heart and (2) despite increased ROS and DAG levels in the hearts of UCP3KO mice, insulin sensitivity was maintained. We speculate that UCP3KO mice have developed compensatory mechanisms that prevented the development of insulin resistance despite accumulation of compounds known to induce insulin resistance. These mechanisms remain to be determined in future studies.

Subjects/Keywords: Insulin resistance

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APA (6^th Edition):

Tidwell, T. J. (2009). Insulin signaling in the hearts of uncoupling protein three knockout mice on a high fat diet. (Masters Thesis). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1658/rec/651

Chicago Manual of Style (16^th Edition):

Tidwell, Timothy James. “Insulin signaling in the hearts of uncoupling protein three knockout mice on a high fat diet.” 2009. Masters Thesis, University of Utah. Accessed March 02, 2021. http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1658/rec/651.

MLA Handbook (7^th Edition):

Tidwell, Timothy James. “Insulin signaling in the hearts of uncoupling protein three knockout mice on a high fat diet.” 2009. Web. 02 Mar 2021.

Vancouver:

Tidwell TJ. Insulin signaling in the hearts of uncoupling protein three knockout mice on a high fat diet. [Internet] [Masters thesis]. University of Utah; 2009. [cited 2021 Mar 02]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1658/rec/651.

Council of Science Editors:

Tidwell TJ. Insulin signaling in the hearts of uncoupling protein three knockout mice on a high fat diet. [Masters Thesis]. University of Utah; 2009. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1658/rec/651

3. Rawat, Aditi. Prescriptions, Perceptions and Resistance - A Qualitative Study of Public Perceptions of Antibiotic Prescriptions in Noida, India.

Degree: School of Public Health, 2017, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:733487/

► Background/Objective: The burden of antibiotic resistance is growing and the lack of adherence to antibiotics is a major reason for its increase. Little is known… (more)

Subjects/Keywords: Antibiotics Resistance

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APA (6^th Edition):

Rawat, A. (2017). Prescriptions, Perceptions and Resistance - A Qualitative Study of Public Perceptions of Antibiotic Prescriptions in Noida, India. (Thesis). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:733487/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rawat, Aditi. “Prescriptions, Perceptions and Resistance - A Qualitative Study of Public Perceptions of Antibiotic Prescriptions in Noida, India.” 2017. Thesis, Brown University. Accessed March 02, 2021. https://repository.library.brown.edu/studio/item/bdr:733487/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rawat, Aditi. “Prescriptions, Perceptions and Resistance - A Qualitative Study of Public Perceptions of Antibiotic Prescriptions in Noida, India.” 2017. Web. 02 Mar 2021.

Vancouver:

Rawat A. Prescriptions, Perceptions and Resistance - A Qualitative Study of Public Perceptions of Antibiotic Prescriptions in Noida, India. [Internet] [Thesis]. Brown University; 2017. [cited 2021 Mar 02]. Available from: https://repository.library.brown.edu/studio/item/bdr:733487/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rawat A. Prescriptions, Perceptions and Resistance - A Qualitative Study of Public Perceptions of Antibiotic Prescriptions in Noida, India. [Thesis]. Brown University; 2017. Available from: https://repository.library.brown.edu/studio/item/bdr:733487/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

4. Wong, Neelum. Development of Improved Chemotherapeutics in Pancreatic and Colorectal Cancer: Ceramide as a Potential Adjuvant with Sigma-2 Receptor Ligands.

Degree: Department of Molecular Pharmacology, Physiology and Biotechnology, 2018, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:792844/

► Pancreatic and colorectal cancer are highly aggressive and challenging to treat. Both cancers have low survival rates and there is a need for more elaborate… (more)

Subjects/Keywords: Drug resistance

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APA (6^th Edition):

Wong, N. (2018). Development of Improved Chemotherapeutics in Pancreatic and Colorectal Cancer: Ceramide as a Potential Adjuvant with Sigma-2 Receptor Ligands. (Thesis). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:792844/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wong, Neelum. “Development of Improved Chemotherapeutics in Pancreatic and Colorectal Cancer: Ceramide as a Potential Adjuvant with Sigma-2 Receptor Ligands.” 2018. Thesis, Brown University. Accessed March 02, 2021. https://repository.library.brown.edu/studio/item/bdr:792844/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wong, Neelum. “Development of Improved Chemotherapeutics in Pancreatic and Colorectal Cancer: Ceramide as a Potential Adjuvant with Sigma-2 Receptor Ligands.” 2018. Web. 02 Mar 2021.

Vancouver:

Wong N. Development of Improved Chemotherapeutics in Pancreatic and Colorectal Cancer: Ceramide as a Potential Adjuvant with Sigma-2 Receptor Ligands. [Internet] [Thesis]. Brown University; 2018. [cited 2021 Mar 02]. Available from: https://repository.library.brown.edu/studio/item/bdr:792844/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wong N. Development of Improved Chemotherapeutics in Pancreatic and Colorectal Cancer: Ceramide as a Potential Adjuvant with Sigma-2 Receptor Ligands. [Thesis]. Brown University; 2018. Available from: https://repository.library.brown.edu/studio/item/bdr:792844/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

5. Durmus, Naside Gozde. Enhanced Efficacy of Nanotechnology-Driven Approaches against Antibiotic-Resistant Biofilms in the Presence of Metabolites.

Degree: PhD, Biomedical Engineering, 2013, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:320579/

► Antibiotic resistance and the lack of new antimicrobial therapies create significant challenges for the treatment of infections. Therefore, there is an urgent clinical need to… (more)

▼ Antibiotic resistance and the lack of new antimicrobial therapies create significant challenges for the treatment of infections. Therefore, there is an urgent clinical need to develop novel treatments targeting bacterial biofilms to reduce the risk of infection, without resorting to antibiotics. The goal of this thesis is, for the first time, to integrate two novel approaches, i.e. nanotechnology and metabolic stimulation, to eradicate antibiotic-resistant biofilms. The metabolic microenvironment of the biofilms has been manipulated to improve the antibacterial properties of superparamagnetic iron oxide nanoparticles (SPION) as well as nanorough device surfaces. First, it has been shown that engineered nanoscale topographies provide surfaces that are more resistant to bacterial growth than conventional polyvinyl chloride (PVC). In addition, for the first time, the presence of fructose on the nanorough PVC further decreased the planktonic S. aureus growth and biofilm formation, without use of any antibiotics. Moreover, a simple, broad-spectrum and low-cost dual-sided approach which uses SPION in combination with metabolites (i.e., fructose, glucose, and mannitol) has been developed as an alternative to existing antibacterial strategies. This strategy offers further improved efficacy of SPION against persistent gram-positive and gram-negative bacteria infections by manipulating the biofilm metabolic microenvironment, creating a new nanotechnology-driven approach. Further, biofilm eradication by the engineered SPION was significantly better than vancomycin, the antibiotic of last resort. In addition, it has been demonstrated that SPION conjugated with antibacterial silver salts exhibit strong eradication properties against the antibiotic-resistant (MRSA) biofilms. Antibacterial properties of silver-conjugated SPION were further improved when an external magnetic field was applied as their magnetic core enabled them to penetrate into the biofilms. This thesis, for the first time, highlighted the importance of biofilm metabolic microenvironment for the nanotechnology-driven approaches. It is envisioned that these simple and inexpensive approaches could lead to novel alternative treatments to the only current clinical option, vancomycin, which MRSA has started to develop a resistance towards. These novel nanotechnology-driven approaches can lead to successful clinical outcomes in terms of minimizing infections, longer medical device lifetimes, and decreasing antibiotic usage. Advisors/Committee Members: Webster, Thomas (Director), Webster, Thomas (Reader), Tripathi, Anubhav (Reader), Sun, Shouheng (Reader), Morgan, Jeffrey (Reader), Tripathi, Anubhav (Director).

Subjects/Keywords: antibiotic resistance

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APA (6^th Edition):

Durmus, N. G. (2013). Enhanced Efficacy of Nanotechnology-Driven Approaches against Antibiotic-Resistant Biofilms in the Presence of Metabolites. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:320579/

Chicago Manual of Style (16^th Edition):

Durmus, Naside Gozde. “Enhanced Efficacy of Nanotechnology-Driven Approaches against Antibiotic-Resistant Biofilms in the Presence of Metabolites.” 2013. Doctoral Dissertation, Brown University. Accessed March 02, 2021. https://repository.library.brown.edu/studio/item/bdr:320579/.

MLA Handbook (7^th Edition):

Durmus, Naside Gozde. “Enhanced Efficacy of Nanotechnology-Driven Approaches against Antibiotic-Resistant Biofilms in the Presence of Metabolites.” 2013. Web. 02 Mar 2021.

Vancouver:

Durmus NG. Enhanced Efficacy of Nanotechnology-Driven Approaches against Antibiotic-Resistant Biofilms in the Presence of Metabolites. [Internet] [Doctoral dissertation]. Brown University; 2013. [cited 2021 Mar 02]. Available from: https://repository.library.brown.edu/studio/item/bdr:320579/.

Council of Science Editors:

Durmus NG. Enhanced Efficacy of Nanotechnology-Driven Approaches against Antibiotic-Resistant Biofilms in the Presence of Metabolites. [Doctoral Dissertation]. Brown University; 2013. Available from: https://repository.library.brown.edu/studio/item/bdr:320579/

6. Vecchione, James J. Using Chemical, Genetic, and Biochemical Approaches to Understand and Circumvent Antibacterial Drug Resistance.

Degree: PhD, Chemistry, 2011, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:11186/

► The growing number of drug-resistant pathogenic bacteria is an impending public health crisis. Unfortunately, the rate at which pathogenic bacteria are developing resistance to our… (more)

Subjects/Keywords: Antibiotic Resistance

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APA (6^th Edition):

Vecchione, J. J. (2011). Using Chemical, Genetic, and Biochemical Approaches to Understand and Circumvent Antibacterial Drug Resistance. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:11186/

Chicago Manual of Style (16^th Edition):

Vecchione, James J. “Using Chemical, Genetic, and Biochemical Approaches to Understand and Circumvent Antibacterial Drug Resistance.” 2011. Doctoral Dissertation, Brown University. Accessed March 02, 2021. https://repository.library.brown.edu/studio/item/bdr:11186/.

MLA Handbook (7^th Edition):

Vecchione, James J. “Using Chemical, Genetic, and Biochemical Approaches to Understand and Circumvent Antibacterial Drug Resistance.” 2011. Web. 02 Mar 2021.

Vancouver:

Vecchione JJ. Using Chemical, Genetic, and Biochemical Approaches to Understand and Circumvent Antibacterial Drug Resistance. [Internet] [Doctoral dissertation]. Brown University; 2011. [cited 2021 Mar 02]. Available from: https://repository.library.brown.edu/studio/item/bdr:11186/.

Council of Science Editors:

Vecchione JJ. Using Chemical, Genetic, and Biochemical Approaches to Understand and Circumvent Antibacterial Drug Resistance. [Doctoral Dissertation]. Brown University; 2011. Available from: https://repository.library.brown.edu/studio/item/bdr:11186/

University of Debrecen

7. Tosin, Ogungbemile. Employee resistance towards organizational changes .

Degree: DE – TEK – Közgazdaság- és Gazdaségtudományi Kar, 2011, University of Debrecen

URL: http://hdl.handle.net/2437/118063

► I want to show my sincere gratitude to all those who made this study possible. First of all, i am very thankful to the helpful… (more)

Subjects/Keywords: employee resistance

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APA (6^th Edition):

Tosin, O. (2011). Employee resistance towards organizational changes . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/118063

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tosin, Ogungbemile. “Employee resistance towards organizational changes .” 2011. Thesis, University of Debrecen. Accessed March 02, 2021. http://hdl.handle.net/2437/118063.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tosin, Ogungbemile. “Employee resistance towards organizational changes .” 2011. Web. 02 Mar 2021.

Vancouver:

Tosin O. Employee resistance towards organizational changes . [Internet] [Thesis]. University of Debrecen; 2011. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2437/118063.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tosin O. Employee resistance towards organizational changes . [Thesis]. University of Debrecen; 2011. Available from: http://hdl.handle.net/2437/118063

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manitoba

8. Wierzbowski, Aleksandra K. Evolution and molecular characterization of clinical respiratory macrolide-resistant Streptococcus pneumoniae in Canada.

Degree: Medical Microbiology, 2012, University of Manitoba

URL: http://hdl.handle.net/1993/5072

► The purpose of this thesis was to molecularly characterize macrolide-resistant S. pneumoniae (SPN) isolates in Canada between 1998 and 2008. The characterization involved looking at… (more)

▼ The purpose of this thesis was to molecularly characterize macrolide-resistant S. pneumoniae (SPN) isolates in Canada between 1998 and 2008. The characterization involved looking at the multi-drug resistant phenotype (MDR), the mechanisms of macrolide resistance, the genetic relatedness, the serotype distribution and PCV7 vaccine coverage as well as the determination of presence of pili-virulence factors. The hypothesis of the study was that macrolide-resistant SPN will growingly be MDR, genetically related, piliated and consisting of serotypes not found in PCV7 vaccine. Over 1500 macrolide-resistant SPN isolates collected between 1998 and 2008 were studied. Macrolide-resistant isolates came from patients from all regions of Canada, and from all age groups. They came from slightly more males (60%) and slightly more in-patients (62%). Macrolide resistant SPN remained low at 8% during the first 4 years of the study, and started to increase reaching 22% by the end of the study in 2008 (p=0.001). Overall the most common mechanism of resistance was efflux mediated by mef(A) (51%), followed by target site modification mediated by erm(B) (36%). The efflux mediated macrolide resistance in S. pneumoniae was predominantly due to the presence of subtype E (95%), which was resistant to more antibiotic classes, and was genetically and serotypically more diverse than the A subtype. Isolates carrying both erm(B) and mef(A) macrolide resistance genes increased overtime from 1% (1998) to 19% (2008) (p=0.002). Serotype distribution showed a decrease in PCV7 vaccine coverage from 67% to 31% (p=0.0072). Isolates with non-PCV7 serotypes increased overtime from 33% to 57% (p=0.0152). Isolates with serotype 19A increased by 15% (p=0.005). They were found to be multi-drug resistant, carried both erm(B) and mef(A) subtype E macrolide resistance genes, and were genetically related. The presence of virulence factor pili-type 1 (PI-1) and pili-type 2 (PI-2) was found associated with these isolates, possibly contributing to its emergence. In conclusion, macrolide resistant SPN increased during the course of this study mostly due to emergence of multi-drug resistant, genetically related, piliated, 19A S. pneumoniae. Advisors/Committee Members: Zhanel, George (Medical Microbiology) (supervisor), Embree, Joanne (Medical Microbiology) Worobec, Elizabeth (Microbiology) Mulvey, Michael (Medical Microbiology) Hoban, Daryl (Medical Microbiology) Farrell, David (JMI Laboratories) (examiningcommittee).

Subjects/Keywords: Resistance; Macrolides

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APA (6^th Edition):

Wierzbowski, A. K. (2012). Evolution and molecular characterization of clinical respiratory macrolide-resistant Streptococcus pneumoniae in Canada. (Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/5072

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wierzbowski, Aleksandra K. “Evolution and molecular characterization of clinical respiratory macrolide-resistant Streptococcus pneumoniae in Canada.” 2012. Thesis, University of Manitoba. Accessed March 02, 2021. http://hdl.handle.net/1993/5072.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wierzbowski, Aleksandra K. “Evolution and molecular characterization of clinical respiratory macrolide-resistant Streptococcus pneumoniae in Canada.” 2012. Web. 02 Mar 2021.

Vancouver:

Wierzbowski AK. Evolution and molecular characterization of clinical respiratory macrolide-resistant Streptococcus pneumoniae in Canada. [Internet] [Thesis]. University of Manitoba; 2012. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1993/5072.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wierzbowski AK. Evolution and molecular characterization of clinical respiratory macrolide-resistant Streptococcus pneumoniae in Canada. [Thesis]. University of Manitoba; 2012. Available from: http://hdl.handle.net/1993/5072

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manitoba

9. Wang, Duoduo. Transferring blackleg resistance from Brassica carinata and synthetic hexaploid Brassica accessions into Brassica napus.

Degree: Plant Science, 2016, University of Manitoba

URL: http://hdl.handle.net/1993/31196

► Blackleg caused by Leptosphaeria maculans (Desm.) Ces. & De Not. is one of the most serious diseases in canola production. A high level of blackleg… (more)

▼ Blackleg caused by Leptosphaeria maculans (Desm.) Ces. & De Not. is one of the most serious diseases in canola production. A high level of blackleg resistance has been shown in Brassica carinata A. Braun (BBCC) and new synthetic hexaploid Brassica species (AABBCC) developed from the crosses of B. rapa L. and B. carinata. Blackleg resistance from B. carinata and hexaploid Brassica accessions was transferred into B. napus L. using interspecific hybridization followed by backcrossing to a susceptible B. napus cultivar ‘Westar’ three or four times and selfing one or two times to produce pure lines. Leptosphaeria maculans isolate 03-15-03 was used to select the resistant plants in each generation using cotyledon inoculation, and four L. maculans isolates (03-15-03, 3-42-6, 09stonewall9553, and PG4-1-M) were utilized in advanced generations. In the cross of B. napus ‘Westar’ and B. carinata, all plants in the F1 showed a high level of resistance to L. maculans isolate 03-15-03. According to the chi-square testing for goodness of fit, the segregation of resistant and susceptible plants fit a 1:1 ratio in the BC1, BC3, and BC4. In the BC3F2, two families followed a 3:1 segregation ratio of resistant and susceptible plants. The results suggest that the resistance to L. maculans transferred from B. carinata into canola ‘Westar’ was controlled by a single locus. Embryo rescue tissue culture was used to obtain F1 plants of the crosses of ‘Westar’ and synthetic hexaploid Brassica accessions. In the BC1 and BC2, most families did not fit a 1:1 segregation ratio of resistant and susceptible plants. The segregation of resistant and susceptible plants fit a 3:1 ratio when inoculated with L. maculans isolates in the BC1F2-3.1.1s and BC1F3-3.1.1.1ss families. Meanwhile, the BC2-3.1.1 family also followed a 1:1 segregation of resistant and susceptible plants inoculated with L. maculans isolate 03-15-03. The results suggest that the resistance to L. maculans introgressed from synthetic hexaploid Brassica species into B. napus is most likely controlled by a single locus. Advisors/Committee Members: Genyi Li (Plant Science) (supervisor), Robert Duncan (Plant science) Thomas Booth (Biological sciences) (examiningcommittee).

Subjects/Keywords: blackleg resistance

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APA (6^th Edition):

Wang, D. (2016). Transferring blackleg resistance from Brassica carinata and synthetic hexaploid Brassica accessions into Brassica napus. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/31196

Chicago Manual of Style (16^th Edition):

Wang, Duoduo. “Transferring blackleg resistance from Brassica carinata and synthetic hexaploid Brassica accessions into Brassica napus.” 2016. Masters Thesis, University of Manitoba. Accessed March 02, 2021. http://hdl.handle.net/1993/31196.

MLA Handbook (7^th Edition):

Wang, Duoduo. “Transferring blackleg resistance from Brassica carinata and synthetic hexaploid Brassica accessions into Brassica napus.” 2016. Web. 02 Mar 2021.

Vancouver:

Wang D. Transferring blackleg resistance from Brassica carinata and synthetic hexaploid Brassica accessions into Brassica napus. [Internet] [Masters thesis]. University of Manitoba; 2016. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1993/31196.

Council of Science Editors:

Wang D. Transferring blackleg resistance from Brassica carinata and synthetic hexaploid Brassica accessions into Brassica napus. [Masters Thesis]. University of Manitoba; 2016. Available from: http://hdl.handle.net/1993/31196

10. García Cazorla, Yolanda. Inhibition of the conjugative traffic ATPase TrwD by fatty acid derivatives: Inhibición de la ATPasa conjugativa TrwD por derivados de ácidos grasos.

Degree: 2018, Universidad de Cantabria

URL: http://hdl.handle.net/10902/14718

► ABSTRACT: Antibiotic resistance has become a pressing public health concern. The main mechanism for the dissemination of resistance genes is the horizontal transfer during conjugation.… (more)

▼ ABSTRACT: Antibiotic resistance has become a pressing public health concern. The main mechanism for the dissemination of resistance genes is the horizontal transfer during conjugation. Hence, the search for conjugation inhibitors (COINs) is paramount in the fight against the spread of resistances. In this pursuit, only unsaturated fatty acids had been described as COINs. Here, we define 2-bromopalmitic acid (2-BP) as a specific COIN. 2-BP is a palmitate analog without any unsaturation in its aliphatic chain which acts as inhibitor of many membrane-associated enzymes. The carboxylic group of COINs is essential for its effectivity. However, inhibition is not due to the presence of double or triple bonds in these compounds but, indirectly, by the conformation COINs can acquire upon binding to their molecular target. We identify the VirB11 homolog in the conjugative plasmid R388, the traffic ATPase TrwD, as their molecular target. VirB11 form hexameric rings in which each monomer has a C-terminal catalytic region (CTD) and a N-terminal region that interacts with the cytoplasmic site of the membrane (NTD) connected both of them by a flexible linker. Biochemical and structural characterizations define a non-competitive inhibition where COINs bind to a pocket comprised by NTD and linker, preventing the pivoting movement of NTD over CTD which, in turn, result in a reduction of TrwD ATPase activity. Interestingly, COINs are liberally incorporated into bacterial membranes, replacing palmitic acid as the major component. We determine that TrwD binds palmitic acid, thus facilitating its interaction with the membrane. Altogether, our data suggest that COINs bind TrwD at a site that is otherwise occupied by palmitic acid, albeit they differ in the contacts involved in the interaction. As a result, COINs affect the interaction of TrwD with the membrane. For a further understand of the conjugative process, we visualized the process in real time using fluorescent protein fusions to the main players in the conjugative system. Localization of the proteins suffers dramatic changes in the presence or absence of the rest of the component of the Type IV secretion system (T4SS). Moreover, by using fluorescent constructs of SeqA, a probe that binds hemimethylated DNA, we have found, surprisingly, that more than one event of conjugation takes place at a particular time. Additionally, we identify the formation of a weak complex between TrwD and the relaxase TrwC. TrwD presents structural homology to chaperones of the ClpB/Hsp 104 family, hence TrwD could play a chaperone activity during the transport of the pilot protein TrwC. In short, our results do not only contribute to a better understanding of VirB11 proteins and the conjugative process but also may open a new avenue for the rational design of more potent and effective drugs to control dissemination of antibiotic resistance genes. Advisors/Committee Members: Cabezón Navarro, María Elena (advisor), Universidad de Cantabria (other).

Subjects/Keywords: Antibiotic resistance

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APA (6^th Edition):

García Cazorla, Y. (2018). Inhibition of the conjugative traffic ATPase TrwD by fatty acid derivatives: Inhibición de la ATPasa conjugativa TrwD por derivados de ácidos grasos. (Doctoral Dissertation). Universidad de Cantabria. Retrieved from http://hdl.handle.net/10902/14718

Chicago Manual of Style (16^th Edition):

García Cazorla, Yolanda. “Inhibition of the conjugative traffic ATPase TrwD by fatty acid derivatives: Inhibición de la ATPasa conjugativa TrwD por derivados de ácidos grasos.” 2018. Doctoral Dissertation, Universidad de Cantabria. Accessed March 02, 2021. http://hdl.handle.net/10902/14718.

MLA Handbook (7^th Edition):

García Cazorla, Yolanda. “Inhibition of the conjugative traffic ATPase TrwD by fatty acid derivatives: Inhibición de la ATPasa conjugativa TrwD por derivados de ácidos grasos.” 2018. Web. 02 Mar 2021.

Vancouver:

García Cazorla Y. Inhibition of the conjugative traffic ATPase TrwD by fatty acid derivatives: Inhibición de la ATPasa conjugativa TrwD por derivados de ácidos grasos. [Internet] [Doctoral dissertation]. Universidad de Cantabria; 2018. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/10902/14718.

Council of Science Editors:

García Cazorla Y. Inhibition of the conjugative traffic ATPase TrwD by fatty acid derivatives: Inhibición de la ATPasa conjugativa TrwD por derivados de ácidos grasos. [Doctoral Dissertation]. Universidad de Cantabria; 2018. Available from: http://hdl.handle.net/10902/14718

University of Florida

11. Yuan, Weimin. Evaluation of Resistance to Meloidogyne Arenaria in the Peanut (Arachis Hypogaea. L) Cv. Tifguard.

Degree: PhD, Entomology and Nematology, 2017, University of Florida

URL: https://ufdc.ufl.edu/UFE0050637

► Tifguard, which was released as a peanut cultivar resistant to root-knot nematode and tomato spotted wilt virus in 2007, was found to be heavily infected… (more)

▼ Tifguard, which was released as a peanut cultivar resistant to root-knot nematode and tomato spotted wilt virus in 2007, was found to be heavily infected by Meloidogyne arenaria in several peanut production fields in Florida in 2012. The goal of this project was to determine why the cultivar that was reported to be highly resistant succumbed to root-knot nematode infection. The objectives were to evaluate the resistance of three different sources of Tifguard seeds; to determine the seasonal population changes and vertical population densities of M. arenaria collected from resistant and susceptible peanut rhizospheres in two different soil types; to determine the effects of high temperature on the resistance in Tifguard, and to compare the yield of Tifguard, isogenic Tifguard and Georgia-06G treated vs. nontreated with 1,3-dichloropropene. In three M. arenaria infested field sites, a comparison of Tifguard seed obtained from three sources showed that 2.5, 28, and 39.5% of plants that were infected by the nematode were negative for the nematode resistance gene. The seasonal distribution of second-stage juvenile (J2) of M. arenaria followed similar trends in two different soil types, with a peak occurring during late summer and early fall at harvest. Number of J2 dropped following harvest and reached a density less than 10 J2/200 cm3 of soil in February. Comparison of vertical population densities of J2 collected from Georgia-06G rhizosphere in two different soil types showed that greater numbers occurred in the upper 60 cm of soil during the growing season in a Candler sand, whereas in a Norfolk loamy sand greater densities were found only in the top 45 cm. The population densities of J2 collected from Georgia-06G rhizosphere at all depths were much greater in Norfolk loamy sand than that in the Candler sand. Tifguard reduced the nematode population to 1 and 28 in the Candler sand and the Norfolk loamy sand, respectively at harvest. Comparison of nematode numbers from different developmental stages at different temperatures demonstrated that the high soil temperature increased nematode infection rate and accelerated nematode development in Georgia-06G. No further development of J2 occurred in Tifguard roots at 28 or 31 C, however at 34 C a few J3-J4, females, egg laying females, and males of M. arenaria were observed. Comparisons indicated that there was no effect of 1,3-dichloropropene on root-knot nematode damage and yield of Georgia-06G, Tifguard, or isogenic Tifguard. ( en ) Advisors/Committee Members: DICKSON,DONALD W (committee chair), BRITO,JANETE A (committee member), PRESTON,JAMES F,III (committee member).

Subjects/Keywords: resistance – tifguard

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APA (6^th Edition):

Yuan, W. (2017). Evaluation of Resistance to Meloidogyne Arenaria in the Peanut (Arachis Hypogaea. L) Cv. Tifguard. (Doctoral Dissertation). University of Florida. Retrieved from https://ufdc.ufl.edu/UFE0050637

Chicago Manual of Style (16^th Edition):

Yuan, Weimin. “Evaluation of Resistance to Meloidogyne Arenaria in the Peanut (Arachis Hypogaea. L) Cv. Tifguard.” 2017. Doctoral Dissertation, University of Florida. Accessed March 02, 2021. https://ufdc.ufl.edu/UFE0050637.

MLA Handbook (7^th Edition):

Yuan, Weimin. “Evaluation of Resistance to Meloidogyne Arenaria in the Peanut (Arachis Hypogaea. L) Cv. Tifguard.” 2017. Web. 02 Mar 2021.

Vancouver:

Yuan W. Evaluation of Resistance to Meloidogyne Arenaria in the Peanut (Arachis Hypogaea. L) Cv. Tifguard. [Internet] [Doctoral dissertation]. University of Florida; 2017. [cited 2021 Mar 02]. Available from: https://ufdc.ufl.edu/UFE0050637.

Council of Science Editors:

Yuan W. Evaluation of Resistance to Meloidogyne Arenaria in the Peanut (Arachis Hypogaea. L) Cv. Tifguard. [Doctoral Dissertation]. University of Florida; 2017. Available from: https://ufdc.ufl.edu/UFE0050637

University of Ottawa

12. Laskey, Alexander. Horizontal Transfer of β-Lactam Resistance in the Mouse Gut Microbiota Under Antibiotic Treatment.

Degree: MSc, Médecine / Medicine, 2020, University of Ottawa

URL: http://dx.doi.org/10.20381/ruor-25628

► The rise of β-lactam-resistant bacteria from agricultural settings, including food-producing animals and their related food products has become a significant public health concern. Consumption of… (more)

▼ The rise of β-lactam-resistant bacteria from agricultural settings, including food-producing animals and their related food products has become a significant public health concern. Consumption of food contaminated by such bacteria may cause infection as well as the transmission of resistance genes. Here we used a mouse model to assess the impact of different antibiotic treatments on the composition of the gut microbiota and any impact on the transfer of β-lactam resistance genes between donor and recipient bacteria. Mice were inoculated with β-lactam resistant Escherichia coli and an antibiotic-susceptible Salmonella Heidelberg strain. The mice were treated with either streptomycin, ampicillin or both antibiotics. Mouse feces were collected at regular intervals and processed using selective culture techniques to capture potential transfer of resistance genes. Gene transfer was confirmed by whole genome sequencing. DNA extracted from the feces was used for monitoring changes in microbial profiles by 16S rDNA sequencing. In the absence of antibiotic treatment, the inoculated bacteria were only transiently detected and no transconjugants were recovered from the mouse feces. In comparison, antibiotic treatment changed microbial profiles in the mouse gut, enhanced colonization of the bacterial isolates, and facilitated the transfer of the resistance genes into both S. Heidelberg and commensal E. coli recipient strains. The results of this study indicated that the use of multiple antibiotics may enhance infection of opportunistic β-lactam resistant bacterial pathogens relative to single antibiotics and pose a greater risk in terms of antibiotic resistance gene transfer. Such process might occur in clinical settings where patients are under prolonged antibiotic treatments. Information gained through this study together with future work will inform the development of new policies guiding the prudent use of antibiotics. Advisors/Committee Members: Lin, Min (supervisor), Wang, Lisheng (supervisor).

Subjects/Keywords: Antimicrobial Resistance

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APA (6^th Edition):

Laskey, A. (2020). Horizontal Transfer of β-Lactam Resistance in the Mouse Gut Microbiota Under Antibiotic Treatment. (Masters Thesis). University of Ottawa. Retrieved from http://dx.doi.org/10.20381/ruor-25628

Chicago Manual of Style (16^th Edition):

Laskey, Alexander. “Horizontal Transfer of β-Lactam Resistance in the Mouse Gut Microbiota Under Antibiotic Treatment.” 2020. Masters Thesis, University of Ottawa. Accessed March 02, 2021. http://dx.doi.org/10.20381/ruor-25628.

MLA Handbook (7^th Edition):

Laskey, Alexander. “Horizontal Transfer of β-Lactam Resistance in the Mouse Gut Microbiota Under Antibiotic Treatment.” 2020. Web. 02 Mar 2021.

Vancouver:

Laskey A. Horizontal Transfer of β-Lactam Resistance in the Mouse Gut Microbiota Under Antibiotic Treatment. [Internet] [Masters thesis]. University of Ottawa; 2020. [cited 2021 Mar 02]. Available from: http://dx.doi.org/10.20381/ruor-25628.

Council of Science Editors:

Laskey A. Horizontal Transfer of β-Lactam Resistance in the Mouse Gut Microbiota Under Antibiotic Treatment. [Masters Thesis]. University of Ottawa; 2020. Available from: http://dx.doi.org/10.20381/ruor-25628

University of Canterbury

13. Pilgrim, Michael. The impact of differential friction on curve negotiation speed.

Degree: Master of Engineering in Transportation, Transportation Engineering, 2014, University of Canterbury

URL: http://dx.doi.org/10.26021/3450

► This thesis considers the impact of differential skid resistance between wheel paths on the speed at which a vehicle can safely negotiate a curve. Currently… (more)

Subjects/Keywords: skid resistance

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APA (6^th Edition):

Pilgrim, M. (2014). The impact of differential friction on curve negotiation speed. (Masters Thesis). University of Canterbury. Retrieved from http://dx.doi.org/10.26021/3450

Chicago Manual of Style (16^th Edition):

Pilgrim, Michael. “The impact of differential friction on curve negotiation speed.” 2014. Masters Thesis, University of Canterbury. Accessed March 02, 2021. http://dx.doi.org/10.26021/3450.

MLA Handbook (7^th Edition):

Pilgrim, Michael. “The impact of differential friction on curve negotiation speed.” 2014. Web. 02 Mar 2021.

Vancouver:

Pilgrim M. The impact of differential friction on curve negotiation speed. [Internet] [Masters thesis]. University of Canterbury; 2014. [cited 2021 Mar 02]. Available from: http://dx.doi.org/10.26021/3450.

Council of Science Editors:

Pilgrim M. The impact of differential friction on curve negotiation speed. [Masters Thesis]. University of Canterbury; 2014. Available from: http://dx.doi.org/10.26021/3450

Colorado State University

14. Rovira Sanz, Pablo. Impact of antibiotic use on resistance in beef feedlot and dairy cattle.

Degree: PhD, Animal Sciences, 2017, Colorado State University

URL: http://hdl.handle.net/10217/183928

► In recent years, consumer demand for natural and organic foods has increased, partly due to concerns about the use of antimicrobials in food producing animals.… (more)

▼ In recent years, consumer demand for natural and organic foods has increased, partly due to concerns about the use of antimicrobials in food producing animals. The aim of this study was to evaluate antimicrobial resistance (AMR) in beef feedlot and dairy cattle raised without use of antibiotics compared to cattle raised in conventional (CONV) production. Three research projects were conducted to accomplish that general goal. In the first study, a conventional feedlot, natural feedlot, conventional dairy and organic dairy were visited to collect cattle feces, wastewater from lagoons and soil where the wastewater was applied. After DNA extraction, sequencing, and processing, metagenomic reads were aligned to reference databases for identification of antibiotic resistance genes (ARGs; i.e. the resistome) and bacteria (microbiome). Resistome composition was influenced by rearing method, cattle type, and type of sample. Most mechanisms of resistance affected by rearing method were enriched (P < 0.05) in conventional samples. Resistome differences were greatest for wastewater samples by rearing method but with contradictory results that suggested an impact of effluent management on wastewater resistome. Resistance to tetracycline and macrolide-lincosamide-streptogramin classes were more abundant in feces of feedlot cattle than in dairy cattle (P < 0.05); whereas resistance to beta-lactams was greatest in feces of dairy cattle (P < 0.05). Resistome and microbiome of feces differed (P < 0.05) between wastewater and soil samples. Results indicated that ARGs are widespread in beef feedlot and dairy cattle farms even in those with restricted antibiotic use. In the second study, feces from RWA (n=36) and CONV (n=36) cattle lots were recovered from colons at a commercial beef processing plant. Samples were equally distributed by month and production protocol over one year (3 samples/production protocol/month). After extracting DNA from individual samples, composite samples were prepared by mixing DNA from each lot into a single composite sample (N = 72) and sequencing the composites on an Illumina platform. Metagenomic reads were processed similarly to those in experiment 1for identification of ARGs and bacteria. Resistomes of CONV and RWA cattle were significantly different by season. In general, mechanisms conferring resistance to beta-lactams, tetracyclines, multi-drug and macrolides were more prevalent (P < 0.05) in feces from CONV colons than in RWA colons. In the third study, a systematic review and meta-analysis was performed to assess the relationship between antimicrobial use (AMU) and antimicrobial resistance (AMR) in feedlot cattle. After conducting a literature search and screening reported studies, 32 studies were selected for use that addressed AMR in Escherichia coli, Enterococcus, Salmonella, Campylobacter, and Mannheimia haemolytica. Overall, 60% (95% CI: 26% to 88%) of the observational studies and 50% (95% CI: 30% to 70%) of the controlled trials reported a positive association between AMU and AMR.… Advisors/Committee Members: Belk, Keith (advisor), Morley, Paul (committee member), Schmidt, John (committee member), Yang, Hua (committee member).

Subjects/Keywords: bacteria; metagenomics; antimicrobial resistance; resistance genes; cattle

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APA (6^th Edition):

Rovira Sanz, P. (2017). Impact of antibiotic use on resistance in beef feedlot and dairy cattle. (Doctoral Dissertation). Colorado State University. Retrieved from http://hdl.handle.net/10217/183928

Chicago Manual of Style (16^th Edition):

Rovira Sanz, Pablo. “Impact of antibiotic use on resistance in beef feedlot and dairy cattle.” 2017. Doctoral Dissertation, Colorado State University. Accessed March 02, 2021. http://hdl.handle.net/10217/183928.

MLA Handbook (7^th Edition):

Rovira Sanz, Pablo. “Impact of antibiotic use on resistance in beef feedlot and dairy cattle.” 2017. Web. 02 Mar 2021.

Vancouver:

Rovira Sanz P. Impact of antibiotic use on resistance in beef feedlot and dairy cattle. [Internet] [Doctoral dissertation]. Colorado State University; 2017. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/10217/183928.

Council of Science Editors:

Rovira Sanz P. Impact of antibiotic use on resistance in beef feedlot and dairy cattle. [Doctoral Dissertation]. Colorado State University; 2017. Available from: http://hdl.handle.net/10217/183928

15. Shawa, Misheck. Risk factors and Alleles of extended spectrum Beta-Lactamase(ESBL) producing Escherichia coli at the University Teaching Hospital, Zambia.

Degree: 2015, University of Zimbabwe

URL: http://dspace.unza.zm/handle/123456789/4464

► The limitation of antibacterial treatment options imposed by the emergence of bacterial resistant organisms calls for the correct identification of the genes involved in mediating… (more)

Subjects/Keywords: Drug resistance, Microbial; Drug resistance in microorganisms

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APA (6^th Edition):

Shawa, M. (2015). Risk factors and Alleles of extended spectrum Beta-Lactamase(ESBL) producing Escherichia coli at the University Teaching Hospital, Zambia. (Thesis). University of Zimbabwe. Retrieved from http://dspace.unza.zm/handle/123456789/4464

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shawa, Misheck. “Risk factors and Alleles of extended spectrum Beta-Lactamase(ESBL) producing Escherichia coli at the University Teaching Hospital, Zambia.” 2015. Thesis, University of Zimbabwe. Accessed March 02, 2021. http://dspace.unza.zm/handle/123456789/4464.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shawa, Misheck. “Risk factors and Alleles of extended spectrum Beta-Lactamase(ESBL) producing Escherichia coli at the University Teaching Hospital, Zambia.” 2015. Web. 02 Mar 2021.

Vancouver:

Shawa M. Risk factors and Alleles of extended spectrum Beta-Lactamase(ESBL) producing Escherichia coli at the University Teaching Hospital, Zambia. [Internet] [Thesis]. University of Zimbabwe; 2015. [cited 2021 Mar 02]. Available from: http://dspace.unza.zm/handle/123456789/4464.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shawa M. Risk factors and Alleles of extended spectrum Beta-Lactamase(ESBL) producing Escherichia coli at the University Teaching Hospital, Zambia. [Thesis]. University of Zimbabwe; 2015. Available from: http://dspace.unza.zm/handle/123456789/4464

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cambridge

16. Rowe, Will. Antimicrobial resistance gene monitoring in aquatic environments.

Degree: PhD, 2016, University of Cambridge

URL: https://www.repository.cam.ac.uk/handle/1810/253755https://www.repository.cam.ac.uk/bitstream/1810/253755/2/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/253755/3/license_rdf ; https://www.repository.cam.ac.uk/bitstream/1810/253755/4/DISSERTATION.corrected.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/253755/5/DISSERTATION.corrected.pdf.jpg

► This dissertation documents the development of an environmental framework for monitoring antimicrobial resistance gene (ARG) dissemination in the aquatic environment. The work opens with a… (more)

▼ This dissertation documents the development of an environmental framework for monitoring antimicrobial resistance gene (ARG) dissemination in the aquatic environment. The work opens with a review of the relevant literature and outlines the importance of an environmental framework for monitoring ARG dissemination as part of antimicrobial resistance risk assessments. The ability to interrogate sequencing data quickly and easily for the presence of ARGs is crucial in order to facilitate their monitoring in the environment. As current laboratory methods for the detection and surveillance of antimicrobial resistant bacteria in the environment were limited in their effectiveness and scope, the dissertation begins by describing the design and implementation of a Search Engine for Antimicrobial Resistance (SEAR), a pipeline and web interface for detection of horizontally-acquired ARGs in raw sequencing data. The suitability of metagenomic methods for monitoring the ARG content of effluents from faecal sources was then assessed via a pilot study of a river catchment. Novel metagenomes generated from effluents entering the catchment were interrogated for ARGs. The relative abundance of ARGs in effluents were determined to be higher relative to the background environment, as were sequences relating to human and animal pathogens and mobile genetic elements. Thus, effluents were implicated in the dissemination of ARGs throughout the aquatic environment. To determine if ARGs were potentially in use in the environment, the expression of ARGs within effluents was then evaluated across a series of longitudinal samples through the use of metatranscriptomics, and the presence of potential environmental antimicrobial selection pressures was examined. This demonstrated that the abundance of ARGs, as well as antimicrobial usage at the effluent source, was correlated with the transcription of ARGs in aquatic environments. The work described in this dissertation has also found that horizontally transmitted ARGs were present in pathogenic endospore-forming bacteria commonly found across the aquatic environment, potentially providing a mechanism for ARG persistence in the environment. Finally, these findings were integrated into a universal framework for monitoring ARG dissemination in aquatic environments and used to highlight the developments required to incorporate this framework into future environmental ARG research and to facilitate antimicrobial resistance risk assessments.

Subjects/Keywords: Metagenomics; Antimicrobial resistance; Antibiotic resistance; Wastewater

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APA (6^th Edition):

Rowe, W. (2016). Antimicrobial resistance gene monitoring in aquatic environments. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/253755https://www.repository.cam.ac.uk/bitstream/1810/253755/2/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/253755/3/license_rdf ; https://www.repository.cam.ac.uk/bitstream/1810/253755/4/DISSERTATION.corrected.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/253755/5/DISSERTATION.corrected.pdf.jpg

Chicago Manual of Style (16^th Edition):

Rowe, Will. “Antimicrobial resistance gene monitoring in aquatic environments.” 2016. Doctoral Dissertation, University of Cambridge. Accessed March 02, 2021. https://www.repository.cam.ac.uk/handle/1810/253755https://www.repository.cam.ac.uk/bitstream/1810/253755/2/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/253755/3/license_rdf ; https://www.repository.cam.ac.uk/bitstream/1810/253755/4/DISSERTATION.corrected.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/253755/5/DISSERTATION.corrected.pdf.jpg.

MLA Handbook (7^th Edition):

Rowe, Will. “Antimicrobial resistance gene monitoring in aquatic environments.” 2016. Web. 02 Mar 2021.

Vancouver:

Rowe W. Antimicrobial resistance gene monitoring in aquatic environments. [Internet] [Doctoral dissertation]. University of Cambridge; 2016. [cited 2021 Mar 02]. Available from: https://www.repository.cam.ac.uk/handle/1810/253755https://www.repository.cam.ac.uk/bitstream/1810/253755/2/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/253755/3/license_rdf ; https://www.repository.cam.ac.uk/bitstream/1810/253755/4/DISSERTATION.corrected.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/253755/5/DISSERTATION.corrected.pdf.jpg.

Council of Science Editors:

Rowe W. Antimicrobial resistance gene monitoring in aquatic environments. [Doctoral Dissertation]. University of Cambridge; 2016. Available from: https://www.repository.cam.ac.uk/handle/1810/253755https://www.repository.cam.ac.uk/bitstream/1810/253755/2/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/253755/3/license_rdf ; https://www.repository.cam.ac.uk/bitstream/1810/253755/4/DISSERTATION.corrected.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/253755/5/DISSERTATION.corrected.pdf.jpg

17. Elahi, Mohammad Tariq. Towards more Effective Censorship Resistance Systems.

Degree: 2015, University of Waterloo

URL: http://hdl.handle.net/10012/9744

► Internet censorship resistance systems (CRSs) have so far been designed in an ad-hoc manner. The fundamentals are unclear and the foundations are shaky. Censors are,… (more)

Subjects/Keywords: Censorship Resistance; Censorship Resistance Systems; Circumvention

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APA (6^th Edition):

Elahi, M. T. (2015). Towards more Effective Censorship Resistance Systems. (Thesis). University of Waterloo. Retrieved from http://hdl.handle.net/10012/9744

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Elahi, Mohammad Tariq. “Towards more Effective Censorship Resistance Systems.” 2015. Thesis, University of Waterloo. Accessed March 02, 2021. http://hdl.handle.net/10012/9744.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Elahi, Mohammad Tariq. “Towards more Effective Censorship Resistance Systems.” 2015. Web. 02 Mar 2021.

Vancouver:

Elahi MT. Towards more Effective Censorship Resistance Systems. [Internet] [Thesis]. University of Waterloo; 2015. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/10012/9744.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Elahi MT. Towards more Effective Censorship Resistance Systems. [Thesis]. University of Waterloo; 2015. Available from: http://hdl.handle.net/10012/9744

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cambridge

18. Rowe, Will. Antimicrobial resistance gene monitoring in aquatic environments.

Degree: PhD, 2016, University of Cambridge

URL: https://doi.org/10.17863/CAM.16362 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.683707

► This dissertation documents the development of an environmental framework for monitoring antimicrobial resistance gene (ARG) dissemination in the aquatic environment. The work opens with a… (more)

▼ This dissertation documents the development of an environmental framework for monitoring antimicrobial resistance gene (ARG) dissemination in the aquatic environment. The work opens with a review of the relevant literature and outlines the importance of an environmental framework for monitoring ARG dissemination as part of antimicrobial resistance risk assessments. The ability to interrogate sequencing data quickly and easily for the presence of ARGs is crucial in order to facilitate their monitoring in the environment. As current laboratory methods for the detection and surveillance of antimicrobial resistant bacteria in the environment were limited in their effectiveness and scope, the dissertation begins by describing the design and implementation of a Search Engine for Antimicrobial Resistance (SEAR), a pipeline and web interface for detection of horizontally-acquired ARGs in raw sequencing data. The suitability of metagenomic methods for monitoring the ARG content of effluents from faecal sources was then assessed via a pilot study of a river catchment. Novel metagenomes generated from effluents entering the catchment were interrogated for ARGs. The relative abundance of ARGs in effluents were determined to be higher relative to the background environment, as were sequences relating to human and animal pathogens and mobile genetic elements. Thus, effluents were implicated in the dissemination of ARGs throughout the aquatic environment. To determine if ARGs were potentially in use in the environment, the expression of ARGs within effluents was then evaluated across a series of longitudinal samples through the use of metatranscriptomics, and the presence of potential environmental antimicrobial selection pressures was examined. This demonstrated that the abundance of ARGs, as well as antimicrobial usage at the effluent source, was correlated with the transcription of ARGs in aquatic environments. The work described in this dissertation has also found that horizontally transmitted ARGs were present in pathogenic endospore-forming bacteria commonly found across the aquatic environment, potentially providing a mechanism for ARG persistence in the environment. Finally, these findings were integrated into a universal framework for monitoring ARG dissemination in aquatic environments and used to highlight the developments required to incorporate this framework into future environmental ARG research and to facilitate antimicrobial resistance risk assessments.

Subjects/Keywords: 579; Metagenomics; Antimicrobial resistance; Antibiotic resistance; Wastewater

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APA (6^th Edition):

Rowe, W. (2016). Antimicrobial resistance gene monitoring in aquatic environments. (Doctoral Dissertation). University of Cambridge. Retrieved from https://doi.org/10.17863/CAM.16362 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.683707

Chicago Manual of Style (16^th Edition):

Rowe, Will. “Antimicrobial resistance gene monitoring in aquatic environments.” 2016. Doctoral Dissertation, University of Cambridge. Accessed March 02, 2021. https://doi.org/10.17863/CAM.16362 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.683707.

MLA Handbook (7^th Edition):

Rowe, Will. “Antimicrobial resistance gene monitoring in aquatic environments.” 2016. Web. 02 Mar 2021.

Vancouver:

Rowe W. Antimicrobial resistance gene monitoring in aquatic environments. [Internet] [Doctoral dissertation]. University of Cambridge; 2016. [cited 2021 Mar 02]. Available from: https://doi.org/10.17863/CAM.16362 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.683707.

Council of Science Editors:

Rowe W. Antimicrobial resistance gene monitoring in aquatic environments. [Doctoral Dissertation]. University of Cambridge; 2016. Available from: https://doi.org/10.17863/CAM.16362 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.683707

University of Sydney

19. Seebacher, Nicole Aveline. Overcoming the Dual Mechanism of Stress-Induced, Pgp-Mediated Drug Resistance using Novel Thiosemicarbazones .

Degree: 2015, University of Sydney

URL: http://hdl.handle.net/2123/13847

► Multi-drug resistance (MDR) is the principal mechanism by which many cancers develop resistance to chemotherapy drugs. It is the major factor responsible for the failure… (more)

Subjects/Keywords: P-glycoprotein; Multidrug resistance; Resistance; Chemotherapy

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APA (6^th Edition):

Seebacher, N. A. (2015). Overcoming the Dual Mechanism of Stress-Induced, Pgp-Mediated Drug Resistance using Novel Thiosemicarbazones . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/13847

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Seebacher, Nicole Aveline. “Overcoming the Dual Mechanism of Stress-Induced, Pgp-Mediated Drug Resistance using Novel Thiosemicarbazones .” 2015. Thesis, University of Sydney. Accessed March 02, 2021. http://hdl.handle.net/2123/13847.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Seebacher, Nicole Aveline. “Overcoming the Dual Mechanism of Stress-Induced, Pgp-Mediated Drug Resistance using Novel Thiosemicarbazones .” 2015. Web. 02 Mar 2021.

Vancouver:

Seebacher NA. Overcoming the Dual Mechanism of Stress-Induced, Pgp-Mediated Drug Resistance using Novel Thiosemicarbazones . [Internet] [Thesis]. University of Sydney; 2015. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2123/13847.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Seebacher NA. Overcoming the Dual Mechanism of Stress-Induced, Pgp-Mediated Drug Resistance using Novel Thiosemicarbazones . [Thesis]. University of Sydney; 2015. Available from: http://hdl.handle.net/2123/13847

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Mississippi State University

20. Walker, Ian Daniel. A THEORY OF MUSIC AS POLITICAL RESISTANCE.

Degree: MA, Political Science and Public Administration, 2012, Mississippi State University

URL: http://sun.library.msstate.edu/ETD-db/theses/available/etd-03082012-171433/ ;

► This thesis began as a curiosity about the correlation between politics and music. Closer inspection revealed that there is an absence of literature discussing… (more)

Subjects/Keywords: music; political; resistance

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APA (6^th Edition):

Walker, I. D. (2012). A THEORY OF MUSIC AS POLITICAL RESISTANCE. (Masters Thesis). Mississippi State University. Retrieved from http://sun.library.msstate.edu/ETD-db/theses/available/etd-03082012-171433/ ;

Chicago Manual of Style (16^th Edition):

Walker, Ian Daniel. “A THEORY OF MUSIC AS POLITICAL RESISTANCE.” 2012. Masters Thesis, Mississippi State University. Accessed March 02, 2021. http://sun.library.msstate.edu/ETD-db/theses/available/etd-03082012-171433/ ;.

MLA Handbook (7^th Edition):

Walker, Ian Daniel. “A THEORY OF MUSIC AS POLITICAL RESISTANCE.” 2012. Web. 02 Mar 2021.

Vancouver:

Walker ID. A THEORY OF MUSIC AS POLITICAL RESISTANCE. [Internet] [Masters thesis]. Mississippi State University; 2012. [cited 2021 Mar 02]. Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-03082012-171433/ ;.

Council of Science Editors:

Walker ID. A THEORY OF MUSIC AS POLITICAL RESISTANCE. [Masters Thesis]. Mississippi State University; 2012. Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-03082012-171433/ ;

McMaster University

21. Spanogiannopoulos, Peter. Exploring Rifamycin Inactivation from the Soil Microbiome.

Degree: PhD, 2014, McMaster University

URL: http://hdl.handle.net/11375/16283

►

Our battle against pathogens has become a challenge due to the rise in antibiotic resistance and the dwindling number of new antibiotics entering the clinic.… (more)

▼

Our battle against pathogens has become a challenge due to the rise in antibiotic resistance and the dwindling number of new antibiotics entering the clinic. Most antibiotics owe their origins to soil bacteria, which have been producing these natural products for millennia. The rifamycins are products of actinomycetes and semisynthetic derivatives of these have been very successful in the clinic. Rifampin (RIF) has been a cornerstone agent against tuberculosis for over 50 years. In the clinic, pathogens typically develop RIF resistance by mutation of the drug. Nonetheless, a number of diverse RIF resistance mechanisms have been described, including enzymatic inactivation. Environmental bacteria are multidrug resistant, likely due to sharing the same niche as antibiotic producers and represent a reservoir of ancient resistance determinants. Furthermore, these resistance determinants have been linked to pathogens. Exploring the antibiotic resistome, the collection of all antibiotic resistance determinants from the global microbiota, reveals the diversity and evolution of resistance and provides insight on vulnerabilities of our current antibiotics. Herein, I describe a diverse collection of RIF-inactivating mechanisms from soil actinomycetes. I identified heretofore unknown RIF glycosyltransferase and RIF phosphotransferase genes (rgt and rph, respectively). RGT and RPH enzymes display broad rifamycin specificity and contribute to high-level resistance. Interestingly, RIF-sensitive Gram-positive pathogens are carriers of RPH, highlighting the existence of a ‘silent’ resistome in clinically relevant bacteria and emphasize the importance of studying resistance from environmental bacteria. Furthermore, I identified a conserved upstream DNA motif associated with RIF-inactivating genes from actinomycetes and demonstrate its role in RIF-responsive gene regulation. Finally, I explore the use of a RIF-resistance guided approach to identify novel rifamycin producing bacteria. This study expands the rifamycin resistome, provides evidence of vulnerabilities of our current arsenal of rifamycin antibiotics, and offers a strategy to identify new members of this family natural product family.

Thesis

Doctor of Science (PhD)

Advisors/Committee Members: Wright, Gerard D., Biochemistry and Biomedical Sciences.

Subjects/Keywords: Antibiotic resistance; Microbiology

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APA (6^th Edition):

Spanogiannopoulos, P. (2014). Exploring Rifamycin Inactivation from the Soil Microbiome. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/16283

Chicago Manual of Style (16^th Edition):

Spanogiannopoulos, Peter. “Exploring Rifamycin Inactivation from the Soil Microbiome.” 2014. Doctoral Dissertation, McMaster University. Accessed March 02, 2021. http://hdl.handle.net/11375/16283.

MLA Handbook (7^th Edition):

Spanogiannopoulos, Peter. “Exploring Rifamycin Inactivation from the Soil Microbiome.” 2014. Web. 02 Mar 2021.

Vancouver:

Spanogiannopoulos P. Exploring Rifamycin Inactivation from the Soil Microbiome. [Internet] [Doctoral dissertation]. McMaster University; 2014. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/11375/16283.

Council of Science Editors:

Spanogiannopoulos P. Exploring Rifamycin Inactivation from the Soil Microbiome. [Doctoral Dissertation]. McMaster University; 2014. Available from: http://hdl.handle.net/11375/16283

Queens University

22. Khalifa, Tarek. The Effects of Elevated Temperatures on Fibre Reinforced Polymers for Strengthening Concrete Structures .

Degree: Civil Engineering, 2011, Queens University

URL: http://hdl.handle.net/1974/6559

► Fibre reinforced polymer (FRP) materials have been a material of interest in the field of structural engineering due to their superior mechanical properties such as… (more)

Subjects/Keywords: Fire resistance ; FRP

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APA (6^th Edition):

Khalifa, T. (2011). The Effects of Elevated Temperatures on Fibre Reinforced Polymers for Strengthening Concrete Structures . (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/6559

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Khalifa, Tarek. “The Effects of Elevated Temperatures on Fibre Reinforced Polymers for Strengthening Concrete Structures .” 2011. Thesis, Queens University. Accessed March 02, 2021. http://hdl.handle.net/1974/6559.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Khalifa, Tarek. “The Effects of Elevated Temperatures on Fibre Reinforced Polymers for Strengthening Concrete Structures .” 2011. Web. 02 Mar 2021.

Vancouver:

Khalifa T. The Effects of Elevated Temperatures on Fibre Reinforced Polymers for Strengthening Concrete Structures . [Internet] [Thesis]. Queens University; 2011. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1974/6559.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Khalifa T. The Effects of Elevated Temperatures on Fibre Reinforced Polymers for Strengthening Concrete Structures . [Thesis]. Queens University; 2011. Available from: http://hdl.handle.net/1974/6559

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Stellenbosch University

23. Fouche, Desire. Drug-drug interactions between antiretrovirals and fluconazole in HIV-infected patients.

Degree: MScMedSc, Medicine, 2012, Stellenbosch University

URL: http://hdl.handle.net/10019.1/20079

► ENGLISH ABSTRACT: Background: HIV-positive patients have a significantly weakened immune system which makes them highly susceptible for opportunistic infections, requiring additional treatment. Cryptococcal meningitis and… (more)

▼ ENGLISH ABSTRACT: Background: HIV-positive patients have a significantly weakened immune system which makes them highly susceptible for opportunistic infections, requiring additional treatment. Cryptococcal meningitis and oropharyngeal candidiasis are treated with oral fluconazole. A great potential for drug-drug interactions (DDIs) between fluconazole and antiretrovirals (ARVs), efavirenz, nevirapine, and lopinavir/ritonavir, exists due to interference in common metabolic pathways. The outcome may result in the development of adverse drug reactions or drug resistance and treatment failure. Aim: The primary aim of this thesis was to evaluate the effect of fluconazole on the pharmacokinetics of efavirenz, nevirapine and lopinavir/ritonavir in HIV-infected patients diagnosed with cryptococcal meningitis or oropharyngeal candidiasis. Methods: A prospective study was conducted in 80 HIV-positive, treatment experienced adults (≥18 years old) treated in three different outpatient clinics in the Western Cape region. Patients were subdivided according to ARV regimen and the use of fluconazole. A sparse sampling design was used and corresponding ARV serum concentrations were determined by established HPLC and GC methods. Fluconazole serum concentrations were determined by a newly developed HPLC method. Patient characteristics, concomitant medications, clinical test data and ARV serum concentrations were included in a NONMEM generated, onecompartment, open pharmacometric model with first order elimination to detect any drugdrug interactions between fluconazole and the studied ARVs. The secondary outcome was to establish which patient characteristics influence ARV pharmacokinetics. Results: From 80 outpatients, a total of 276 ARV serum samples (137 efavirenz, 67 nevirapine and 72 lopinavir) were collected for pharmacokinetic evaluation. Efavirenz clearance was correlated with race and concomitant use of rifampicin. No significant covariates were established in the nevirapine model. In the lopinavir model, concomitant use of clotrimazole and the antituberculosis combination isoniazid, pyrazinamide and rifampicin were identified as significant covariates. Discussion: No significant effects of fluconazole on the pharmacokinetics of any of the studied ARVs were observed. Varying efavirenz plasma concentrations in different ethnic populations may be due to differences in gene expression particularly CYP2B6. Coloured patients had significantly lower efavirenz serum concentrations (56.8% decrease in clearance), which has not been previously described in the South African context. Although gender was not a significant covariate in the nevirapine model, female patients tended to have higher nevirapine serum concentrations. TB treatment in all patients receiving lopinavir consisted of a combination of isoniazid, pyrazinamide and rifampicin, each with different effects on CYP isoenzymes. The exact contributing factor of each drug in the ultimate decrease in lopinavir clearance (46.4%) can therefore not… Advisors/Committee Members: Rosenkranz, Bernd, Stellenbosch University. Faculty of Health Sciences. Dept. of Medicine. Pharmacology..

Subjects/Keywords: Pharmacology; Drug resistance

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APA (6^th Edition):

Fouche, D. (2012). Drug-drug interactions between antiretrovirals and fluconazole in HIV-infected patients. (Masters Thesis). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/20079

Chicago Manual of Style (16^th Edition):

Fouche, Desire. “Drug-drug interactions between antiretrovirals and fluconazole in HIV-infected patients.” 2012. Masters Thesis, Stellenbosch University. Accessed March 02, 2021. http://hdl.handle.net/10019.1/20079.

MLA Handbook (7^th Edition):

Fouche, Desire. “Drug-drug interactions between antiretrovirals and fluconazole in HIV-infected patients.” 2012. Web. 02 Mar 2021.

Vancouver:

Fouche D. Drug-drug interactions between antiretrovirals and fluconazole in HIV-infected patients. [Internet] [Masters thesis]. Stellenbosch University; 2012. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/10019.1/20079.

Council of Science Editors:

Fouche D. Drug-drug interactions between antiretrovirals and fluconazole in HIV-infected patients. [Masters Thesis]. Stellenbosch University; 2012. Available from: http://hdl.handle.net/10019.1/20079

University of Saskatchewan

24. Denton, Alyssa. CHARACTERIZING DRUG-RESISTANCE IN ADULTS WITH NEW-ONSET EPILEPSY.

Degree: 2020, University of Saskatchewan

URL: http://hdl.handle.net/10388/12955

► Background and objectives: There are very few studies reporting the factors involved in or the rate of drug-resistant epilepsy (DRE) in adults with new-onset epilepsy… (more)

▼ Background and objectives: There are very few studies reporting the factors involved in or the rate of drug-resistant epilepsy (DRE) in adults with new-onset epilepsy (NOE). This prospective cohort study characterizes DRE and risk factors in a pure adult cohort with NOE or newly diagnosed epilepsy (NDE). There are very few studies reporting the factors involved in or the rate of DRE in adults with NO and NDE. Methods: Patients were selected from a prospective cohort followed between 2011 and 2018 from the Single Seizure Clinic (SSC) in Saskatoon, SK. The SSC sees patients who experience their first seizure and approximately 30% are diagnosed with epilepsy. We identified the following variables and outcomes in the cohort: age, gender, epilepsy type, seizure onset, etiology, epilepsy syndromes, EEG and imaging outcomes, and the rates of DRE. Inclusion criteria included patients with NO and NDE, age 18 years or older at time of diagnosis, and a minimum 1 year of follow‐up. Results: Ninety-five patients were included, 46 females and 49 males. Median age of onset was 33 years. Of those, 20.0% developed DRE between 2011-2018. Average time between onset and DRE diagnosis was 2.32 years. Bivariate analysis identified age, gender, and etiology as important risk factors for DRE, however these variables failed to be significant in the multivariate model. Discussion: A lower percentage of DRE was identified in this cohort of adults compared to any other published study at present. The majority of patients to develop DRE were diagnosed in the first year of follow up, showing the importance of early characterization and treatment. Similarly, a younger age of onset was shown to be a substantial indicator of the prognosis. Despite a small cohort and insignificant statistical outcomes, our findings might guide the directions of future research in this topic. Significance: The specificity of the cohort along with the outcomes identified in this study contribute valuable information about NOE in adults and the development of DRE. This study has laid the groundwork for not only a larger cohort study to be implemented in the future, but also several other studies to evaluate potential predictors such as specific imaging results as a risk factor for DRE and quality of life assessment through follow-up related to DRE risk. Advisors/Committee Members: Tellez-Zenteno, Jose, Pena-Sanchez, Juan-Nicolas, Kirk, Andrew, Thorpe, Lilian, Camfield, Peter.

Subjects/Keywords: epilepsy; drug-resistance

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APA (6^th Edition):

Denton, A. (2020). CHARACTERIZING DRUG-RESISTANCE IN ADULTS WITH NEW-ONSET EPILEPSY. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/12955

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Denton, Alyssa. “CHARACTERIZING DRUG-RESISTANCE IN ADULTS WITH NEW-ONSET EPILEPSY.” 2020. Thesis, University of Saskatchewan. Accessed March 02, 2021. http://hdl.handle.net/10388/12955.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Denton, Alyssa. “CHARACTERIZING DRUG-RESISTANCE IN ADULTS WITH NEW-ONSET EPILEPSY.” 2020. Web. 02 Mar 2021.

Vancouver:

Denton A. CHARACTERIZING DRUG-RESISTANCE IN ADULTS WITH NEW-ONSET EPILEPSY. [Internet] [Thesis]. University of Saskatchewan; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/10388/12955.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Denton A. CHARACTERIZING DRUG-RESISTANCE IN ADULTS WITH NEW-ONSET EPILEPSY. [Thesis]. University of Saskatchewan; 2020. Available from: http://hdl.handle.net/10388/12955

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Univerzitet u Beogradu

25. Aksentijević, Ksenija, 1978-. Ispitivanje rezistencije na antibiotike kod sojeva bakterija izolovanih od riba poreklom iz različitih sredina.

Degree: Fakultet veterinarske medicine, 2017, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:14585/bdef:Content/get

►

Preventivna veterinarska medicina - Bolesti riba, Mikrobiologija; Rezistencija bakterija / Preventive veterinary medicine - Fish diseases, Microbiology, Bacterial resistance to

U ovom ispitivanju vršeno je… (more)

▼

Preventivna veterinarska medicina - Bolesti riba, Mikrobiologija; Rezistencija bakterija / Preventive veterinary medicine - Fish diseases, Microbiology, Bacterial resistance to

U ovom ispitivanju vršeno je uzorkovanje briseva poreklom od klinički zdravih riba koje su poticale iz različitih sredina (ribnjaci, akvarijumi, riblje pijace). Izvršena je izolacija bakterija koje su sastavni deo mikrobioma kože, škrga i creva riba i ispitivana je osetljivost ovih bakterija na određeni broj antibiotika koji se koriste u veterinarskoj i humanoj medicinskoj praksi. Precizna identifikacija ispitivanih sojeva bakterija vršena je primenom metoda PCR, sekvenciranje gena za 16S rRNK, MALDI-TOF. Primenom disk difuzionog testa i E testa ispitivano je fenotipsko ispoljavanje rezistencije na karbapeneme, ureidopeniciline sa i bez inhibitora betalaktamaza, cefalospirine III i IV generacije, aminoglikozide, tetraciklin, kolistin, flurohinolone i hloramfenikol. Prisustvo gena rezistencije, njihova lokalizacija (na hromozomu ili na mobilnim genetičkim elementima) vršena je primenom metode PCR. Kod sojeva koji su ispoljili rezistenciju na nabrojane antibiotike traženi su plazmidi i ispitivana je konjugabilnost izolovanih plazmida. Posmatrano na ukupan broj ispitanih sojeva u ovom istraživanju, bez obzira na rod i vrstu bakterija, ukupno je nađeno 55% sojeva koji su bili osetljivi na sve antibiotike, kod 22,8% sojeva nađena je rezistencija na 3 do 16 antibiotika uključujući i antibiotike koji se koriste isključivo kod ljudi (karbapenemi, ureidopenicilini, cefalosporini III i IV generacije). Ukupno 22,2% sojeva bilo je rezistentno na 1 do 2 antibiotika, mada je i među tim sojevima bilo onih koji su bili rezistentni na antibiotike registrovane samo za upotrebu kod ljudi (ceftazidim, piperacilin). Kod soja A. hydrophila izolovanom iz akvarijumske ribice gupi potvrđen je mehanizam rezistencije nalazom gena rmtB koji je bio lokalizovan na transpozonu Tn1548 smeštenom na konjugabilnom plazmidu koji je po tipu replikona bio kategorisan u grupu IncL/M. Kod sojeva Pseudomonas koji su bili rezistentni na karbapeneme, ureidopeniciline sa i bez inhibitora betalaktamaza, kao i na cefalosporine III i IV generacije, nisu nađeni geni za, karbapenemaze, MßL, ESBL, OXA i AmpC beta-laktamaze (KPC, OXA-23, OXA- 24, OXA-40, OXA-58, VIM, IMP, SPM, GIM, NDM, TEM, SHV, CTX-M-1, CTXM- 9, OXA-1, OXA-9, AmpC grupni kao i pojedinačni-MOXM, CITM, ACCM, EBCM, FOXM, DHAM).Na osnovu dobijenih rezultata primenom E testa, kod 3 soja iz roda Pseudomonas izolovanih od šarana nađena je rezistencija na kolistin sa dobijenim vrednostima MIK 4 μg/mL.

Advisors/Committee Members: Mišić, Dušan, 1969-.

Subjects/Keywords: fish; antibiotics; resistance

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APA (6^th Edition):

Aksentijević, Ksenija, 1. (2017). Ispitivanje rezistencije na antibiotike kod sojeva bakterija izolovanih od riba poreklom iz različitih sredina. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:14585/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Aksentijević, Ksenija, 1978-. “Ispitivanje rezistencije na antibiotike kod sojeva bakterija izolovanih od riba poreklom iz različitih sredina.” 2017. Thesis, Univerzitet u Beogradu. Accessed March 02, 2021. https://fedorabg.bg.ac.rs/fedora/get/o:14585/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Aksentijević, Ksenija, 1978-. “Ispitivanje rezistencije na antibiotike kod sojeva bakterija izolovanih od riba poreklom iz različitih sredina.” 2017. Web. 02 Mar 2021.

Vancouver:

Aksentijević, Ksenija 1. Ispitivanje rezistencije na antibiotike kod sojeva bakterija izolovanih od riba poreklom iz različitih sredina. [Internet] [Thesis]. Univerzitet u Beogradu; 2017. [cited 2021 Mar 02]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:14585/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Aksentijević, Ksenija 1. Ispitivanje rezistencije na antibiotike kod sojeva bakterija izolovanih od riba poreklom iz različitih sredina. [Thesis]. Univerzitet u Beogradu; 2017. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:14585/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Tasmania

26. St-Pierre, P. Role of the microvasculature in the development of muscle insulin resistance.

Degree: 2010, University of Tasmania

URL: https://eprints.utas.edu.au/22258/1/whole_St-PierrePhilippe2010_thesis.pdf

► Type 2 diabetes is a disease characterised by a decrease in the sensitivity to insulin. Recently evidence has suggested an involvement of the microvasculature in… (more)

▼ Type 2 diabetes is a disease characterised by a decrease in the sensitivity to insulin. Recently evidence has suggested an involvement of the microvasculature in the development of type 2 diabetes. Microvascular perfusion is increased by insulin and impairment of this response may contribute to muscle insulin resistance by limiting insulin and glucose delivery to skeletal muscle myocytes. This thesis focuses on the involvement of the microvascular perfusion in the development of insulin resistance. Two different models were used to assess the impact of the microvascular perfusion on the insulin-mediated glucose disposal. Firstly, 4 weeks of high-fat diet (HFD model) feeding to rats was used as a pre-diabetic model of insulin resistance. Secondly, partial blockage of skeletal muscle microvascular beds with 15 μm diameter latex microspheres (MS model) was used to assess the effect of decreased muscle microvascular perfusion on insulin sensitivity. In each model, insulin sensitivity was determined during hyperinsulinaemic isoglycaemic clamps in anaesthetized rats. Femoral arterial blood flow (FBF) and microvascular perfusion (assessed by the hindleg metabolism of infused 1-methylxanthine) were measured. Hindleg glucose uptake was determined from arteriovenous difference and FBF and muscle glucose uptake from [(¹⁴)C]-2-deoxyglucose uptake. Insulin-mediated increases in femoral blood flow and glucose uptake were blunted in the HFD rats compared to those on the normal diet, while insulininduced microvascular perfusion was completely abolished. To see whether contraction responses were intact on the HFD, the functional response to electrical stimulation in the HFD rats was explored. The contraction-mediated increase in microvascular perfusion and glucose uptake was unaffected by the HFD. In the MS model, microsphere occlusion of hindleg muscle microvasculature diminished microvascular perfusion as well as insulin-mediated glucose uptake, thus causing a vascular-derived acute state of insulin resistance. Next, the long-term effect of microsphere occlusion was assessed. Surprisingly, insulin responses following chronic microsphere occlusion were restored by 2 weeks of recovery post-injection. This may be explained by a rapid angiogenic response in occluded muscle vasculature. Collectively, this thesis demonstrates two key findings that highlight the potential role of the microvasculature in the development of skeletal muscle insulin resistance: (i) that insulin- but not contraction-mediated microvascular responses are impaired in a pre-diabetic model of insulin resistance, and (ii) that acute physical reduction of microvascular flow impairs muscle insulin sensitivity. This furthers our understanding of the aetiology of type 2 diabetes and emphasizes the microvasculature as an interesting therapeutic target for the management of type 2 diabetes.

Subjects/Keywords: Insulin resistance; Diabetes

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APA (6^th Edition):

St-Pierre, P. (2010). Role of the microvasculature in the development of muscle insulin resistance. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/22258/1/whole_St-PierrePhilippe2010_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

St-Pierre, P. “Role of the microvasculature in the development of muscle insulin resistance.” 2010. Thesis, University of Tasmania. Accessed March 02, 2021. https://eprints.utas.edu.au/22258/1/whole_St-PierrePhilippe2010_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

St-Pierre, P. “Role of the microvasculature in the development of muscle insulin resistance.” 2010. Web. 02 Mar 2021.

Vancouver:

St-Pierre P. Role of the microvasculature in the development of muscle insulin resistance. [Internet] [Thesis]. University of Tasmania; 2010. [cited 2021 Mar 02]. Available from: https://eprints.utas.edu.au/22258/1/whole_St-PierrePhilippe2010_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

St-Pierre P. Role of the microvasculature in the development of muscle insulin resistance. [Thesis]. University of Tasmania; 2010. Available from: https://eprints.utas.edu.au/22258/1/whole_St-PierrePhilippe2010_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

27. Rashid, Muhammad Mahmudur. Antibiotic resistance in different ecological niches in Bangladesh.

Degree: Ecology and Environmental Sciences, 2013, Umeå University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-84193

► The rapid and wide scale environmental spread of multi-drug resistant bacteria is a seriousissue in recent years. Drug resistant bacteria have already occupied different… (more)

Subjects/Keywords: Antibiotic resistance; Bangladesh

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APA (6^th Edition):

Rashid, M. M. (2013). Antibiotic resistance in different ecological niches in Bangladesh. (Thesis). Umeå University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-84193

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rashid, Muhammad Mahmudur. “Antibiotic resistance in different ecological niches in Bangladesh.” 2013. Thesis, Umeå University. Accessed March 02, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-84193.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rashid, Muhammad Mahmudur. “Antibiotic resistance in different ecological niches in Bangladesh.” 2013. Web. 02 Mar 2021.

Vancouver:

Rashid MM. Antibiotic resistance in different ecological niches in Bangladesh. [Internet] [Thesis]. Umeå University; 2013. [cited 2021 Mar 02]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-84193.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rashid MM. Antibiotic resistance in different ecological niches in Bangladesh. [Thesis]. Umeå University; 2013. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-84193

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Melbourne

28. Hardefeldt, Laura Yvonne. Antimicrobial stewardship in Australian veterinary practices.

Degree: 2017, University of Melbourne

URL: http://hdl.handle.net/11343/198446

► Antimicrobial use by the veterinary profession has been coming under increasing scrutiny by medical, public health and government officials as the threat of antimicrobial resistance… (more)

▼ Antimicrobial use by the veterinary profession has been coming under increasing scrutiny by medical, public health and government officials as the threat of antimicrobial resistance becomes increasingly clear. The World Health Organisation has described antimicrobial resistance as one of the major public health challenges of our time. It is clear that at least some drug-resistant pathogens have evolved under selective pressure from antimicrobial use in agriculture and may be contributing significantly to resistance in clinical setting. Antimicrobial stewardship is the selection of the most appropriate antimicrobial for a given disease in a given animal, with the aim of reducing the risk of adverse effects in that animal, and reducing the likelihood of developing resistance on an individual level, on a farm level and on a national level. Currently none of the core elements of antimicrobial stewardship are widely available for veterinarians in Australia, and there is very sparse data available on which to base an antimicrobial stewardship program. This research project aims to address this paucity of data. A range of research methods were used to assess detailed antimicrobial use by veterinarians in Australia and the enablers and barriers to antimicrobial stewardship. These included quantitative methods such as surveys and analysis of pet insurance data, and qualitative methods such as interviews and focus groups. While antimicrobials with low importance rating were predominately used in all species, under-dosing and inappropriate timing of antimicrobial therapy were common particularly in horses and cattle. Few veterinary practices in Australia had antimicrobial stewardship policies in place, or were using antimicrobial use guidelines. The key barriers to implementing antimicrobial stewardship programs were a lack of antimicrobial stewardship governance structures, client expectations and competition between practices, the cost of microbiological testing, and a lack of access to education, training and antimicrobial stewardship resources. The enablers were, firstly, concern for the role of veterinary antimicrobial use in development of antimicrobial resistance in humans, secondly , a sense of pride in the service provided, and thirdly , preparedness to change prescribing practices. This research culminated in the development of a proposed antimicrobial stewardship policy and procedure documents, to enable veterinarians to institute antimicrobial stewardship programs that suit their individual practice requirements. However, it is likely that governance changes will be necessary to compel veterinary practice owners to implement antimicrobial stewardship on a large scale.

Subjects/Keywords: antibiotic; antimicrobial resistance

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hardefeldt, L. Y. (2017). Antimicrobial stewardship in Australian veterinary practices. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/198446

Chicago Manual of Style (16^th Edition):

Hardefeldt, Laura Yvonne. “Antimicrobial stewardship in Australian veterinary practices.” 2017. Doctoral Dissertation, University of Melbourne. Accessed March 02, 2021. http://hdl.handle.net/11343/198446.

MLA Handbook (7^th Edition):

Hardefeldt, Laura Yvonne. “Antimicrobial stewardship in Australian veterinary practices.” 2017. Web. 02 Mar 2021.

Vancouver:

Hardefeldt LY. Antimicrobial stewardship in Australian veterinary practices. [Internet] [Doctoral dissertation]. University of Melbourne; 2017. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/11343/198446.

Council of Science Editors:

Hardefeldt LY. Antimicrobial stewardship in Australian veterinary practices. [Doctoral Dissertation]. University of Melbourne; 2017. Available from: http://hdl.handle.net/11343/198446

Louisiana State University

29. Vives Habeych, Maria Carolina. Yogurt cultures survive upon exposure to two antimicrobials and Streptococcus thermophilus ST-M5 acquired resistance to both antimicrobials.

Degree: MS, Animal Sciences, 2012, Louisiana State University

URL: etd-04242012-154908 ; https://digitalcommons.lsu.edu/gradschool_theses/789

► Different antimicrobials are added in the manufacturing of dairy products such as flavored yogurts and processed cheese. Potassium Metabisulfite (PM) and Potassium Nitrite (PN) have… (more)

▼ Different antimicrobials are added in the manufacturing of dairy products such as flavored yogurts and processed cheese. Potassium Metabisulfite (PM) and Potassium Nitrite (PN) have been reported to have antimicrobial effect on pathogenic microorganisms such as Clostridium botulinum and Listeria monocytogenes. Yogurt is known for its health benefits, due to the presence of cultured bacteria. PM and PN are not commonly used in the dairy industry hence it would be interesting to study their influence in yogurt culture bacteria. The objectives of this study were: 1. to elucidate the influence of PM and PN at various concentrations, on the growth of yogurt culture and 2. to determine the possible acquisition of resistance after prior exposure to low doses of these antimicrobials. For the first objective different concentrations of PM and PN (100, 1,000, 10,000, 100,000 and 1,000,000ppm) were separately added to broth previously inoculated with Lactobacillus bulgaricus LB-12 and Streptococcus thermophilus ST-M5. Control samples did not receive any antimicrobial. Growth was determined by plating at 0, 24, 48 and 72 hours of incubation. For the second objective, treatments consisted of separately exposing cultures to 100 and 1,000ppm of both antimicrobials and after 24, 48 and 72 hours, transferring them into 10,000 and 100,000ppm, of both antimicrobials. Growth was measured at 0, 24, 48 and 72 hours of incubation. Data were analyzed using Proc Mixed and Repeated Measures model of the Statistical Analysis System SAS®. Differences of Least Square Means where used to determine significant differences. Neither PM nor PN had an antimicrobial effect on yogurt culture Lactobacillus bulgaricus LB-12 or Streptococcus thermophilus ST-M5. Both antimicrobials at 1,000,000ppm significantly increased counts of Streptococcus thermophilus ST-M5 6 log CFU/mL compared to control. Prior exposure of Streptococcus thermophilus ST-M5 to both antimicrobials at 100 and 1,000ppm for 72 hours showed resistance to 10,000 and 100,000ppm of both PM and PN with a significant increase of 6 log CFU/mL compared to control. Commercial applications of this study would be to incorporate PM and PN in yogurt manufacture for inhibition of spoilage and pathogenic bacteria to ensure good preservation of the product and improved shelf life.

Subjects/Keywords: Antimicrobials; inhibition; resistance

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vives Habeych, M. C. (2012). Yogurt cultures survive upon exposure to two antimicrobials and Streptococcus thermophilus ST-M5 acquired resistance to both antimicrobials. (Masters Thesis). Louisiana State University. Retrieved from etd-04242012-154908 ; https://digitalcommons.lsu.edu/gradschool_theses/789

Chicago Manual of Style (16^th Edition):

Vives Habeych, Maria Carolina. “Yogurt cultures survive upon exposure to two antimicrobials and Streptococcus thermophilus ST-M5 acquired resistance to both antimicrobials.” 2012. Masters Thesis, Louisiana State University. Accessed March 02, 2021. etd-04242012-154908 ; https://digitalcommons.lsu.edu/gradschool_theses/789.

MLA Handbook (7^th Edition):

Vives Habeych, Maria Carolina. “Yogurt cultures survive upon exposure to two antimicrobials and Streptococcus thermophilus ST-M5 acquired resistance to both antimicrobials.” 2012. Web. 02 Mar 2021.

Vancouver:

Vives Habeych MC. Yogurt cultures survive upon exposure to two antimicrobials and Streptococcus thermophilus ST-M5 acquired resistance to both antimicrobials. [Internet] [Masters thesis]. Louisiana State University; 2012. [cited 2021 Mar 02]. Available from: etd-04242012-154908 ; https://digitalcommons.lsu.edu/gradschool_theses/789.

Council of Science Editors:

Vives Habeych MC. Yogurt cultures survive upon exposure to two antimicrobials and Streptococcus thermophilus ST-M5 acquired resistance to both antimicrobials. [Masters Thesis]. Louisiana State University; 2012. Available from: etd-04242012-154908 ; https://digitalcommons.lsu.edu/gradschool_theses/789

Queens University

30. McClure, Nathan. Assessing strategies for managing drug resistance in treatment of infectious disease: insights from queueing theory .

Degree: Biology, 2013, Queens University

URL: http://hdl.handle.net/1974/8099

► Antimicrobials have been instrumental in the treatment of infectious disease: responsible for worldwide infection control and reductions in disease-induced morbidity, and mortality. However, in every… (more)

Subjects/Keywords: drug resistance ; evolution

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

McClure, N. (2013). Assessing strategies for managing drug resistance in treatment of infectious disease: insights from queueing theory . (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/8099

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

McClure, Nathan. “Assessing strategies for managing drug resistance in treatment of infectious disease: insights from queueing theory .” 2013. Thesis, Queens University. Accessed March 02, 2021. http://hdl.handle.net/1974/8099.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

McClure, Nathan. “Assessing strategies for managing drug resistance in treatment of infectious disease: insights from queueing theory .” 2013. Web. 02 Mar 2021.

Vancouver:

McClure N. Assessing strategies for managing drug resistance in treatment of infectious disease: insights from queueing theory . [Internet] [Thesis]. Queens University; 2013. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1974/8099.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

McClure N. Assessing strategies for managing drug resistance in treatment of infectious disease: insights from queueing theory . [Thesis]. Queens University; 2013. Available from: http://hdl.handle.net/1974/8099

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations