You searched for subject:(rabies).
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University of Namibia
1.
Kanutus, Benediktus Shiikufeni.
A household survey to assess knowledge, attitudes and practices regarding Rabies among dog owners in Omusati region
.
Degree: 2020, University of Namibia
URL: http://hdl.handle.net/11070/2803 
► Rabies is a viral zoonotic disease of warm-blooded animals caused by Lyssavirus of the Rhabdoviridae family that attacks the Central Nervous System, provoking fatal acute…
(more)
▼ Rabies is a viral zoonotic disease of warm-blooded animals caused by Lyssavirus of the Rhabdoviridae family that attacks the Central Nervous System, provoking fatal acute encephalitis. Domesticated dogs are the main vector, responsible for almost 99% of human rabies cases. Namibia with the rest of the world is engaged in fight to eradicate dog mediated rabies. There is a need to explore the knowledge gaps, attitudes and practices regarding rabies control among dog owners. The purpose of this study was to perform a household survey, assessing knowledge, attitudes and practices regarding rabies control among dog owners in the Omusati region, Namibia.
The researcher applied a quantitative, cross-sectional, descriptive, household survey on residents of five constituencies in Omusati region. The researcher employed a structured questionnaire translated in the local language (Oshiwambo). Participants were selected through a simple random sampling method, and one questionnaire was completed per selected household. The data was analysed through Epi-Info 7 and Microsoft Excel and arranged in descriptive statistics such as frequencies, percentages and proportion to determine the Knowledge, Attitudes and Practice levels. The Chi-square test on categorical variable was used at p-value 0.005 statistical significance. A total of 342 respondents took part in the study; more than half (53%) were male and 50% had secondary education level and only 18% were employed. At least 98% of the respondents knew that rabies is a zoonotic disease and could identify the disease through local names; 55% had no knowledge that rabies is caused by a virus even though 67% were certain the diseases could be transmitted to human through rabid animal bites. Ninety percentages (90%) of the respondents knew that vaccination is the only form of prevention against rabies, and 96% would seek medical help at the hospital after an animal bite. Ninety-five percentages (95%) of the respondents kept guard dogs yet only 29% would report or take a suspected rabid dog to the nearest animal clinic. Sixty-eight percentage (68%) of the respondents consumed dog meat and 71% have had their dogs vaccinated during the last vaccination campaign. Employed respondents were more likely to keep dogs in an enclosure away from stray dogs, significant at chi-square 5.0514, p-value 0.0241. Employment status does not influence dog’s vaccination status at household level, non-significant at chi-square 0.7086, p-value 0.3999. Household knowledge and attitude levels with regards to rabies control in the five constituencies of Omusati region are well above average; however there are gaps in practices in the community. Despite the right knowledge, communities engage in practices that predispose them to rabies infection and others that are hampering and jeopardising efforts towards rabies control.
Subjects/Keywords: Rabies
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APA (6th Edition):
Kanutus, B. S. (2020). A household survey to assess knowledge, attitudes and practices regarding Rabies among dog owners in Omusati region
. (Thesis). University of Namibia. Retrieved from http://hdl.handle.net/11070/2803
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kanutus, Benediktus Shiikufeni. “A household survey to assess knowledge, attitudes and practices regarding Rabies among dog owners in Omusati region
.” 2020. Thesis, University of Namibia. Accessed February 28, 2021.
http://hdl.handle.net/11070/2803.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kanutus, Benediktus Shiikufeni. “A household survey to assess knowledge, attitudes and practices regarding Rabies among dog owners in Omusati region
.” 2020. Web. 28 Feb 2021.
Vancouver:
Kanutus BS. A household survey to assess knowledge, attitudes and practices regarding Rabies among dog owners in Omusati region
. [Internet] [Thesis]. University of Namibia; 2020. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/11070/2803.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kanutus BS. A household survey to assess knowledge, attitudes and practices regarding Rabies among dog owners in Omusati region
. [Thesis]. University of Namibia; 2020. Available from: http://hdl.handle.net/11070/2803
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Zambia
2.
Kalima-Munalula, Mukatimui N.
Utility of immunohistochemical staining technique as a routine tool in Rabies Diagnosis
.
Degree: 2012, University of Zambia
URL: http://hdl.handle.net/123456789/1722
► Rabies is one of few diseases that cause anxiety to both the exposed individual and the health authorities responsible for its prevention and control. Diagnostic…
(more)
▼ Rabies is one of few diseases that cause anxiety to both the exposed individual and the health authorities responsible for its prevention and control. Diagnostic procedures in rabies have involved histopathological detection of the Negri body, immunofluorescence and mouse inoculation.Brain specimens from suspected and confirmed rabies cases were obtained from the University of Zambia, School of Veterinary Medicine, Lusaka. These specimens were taken from dogs, cats, cows and horses. The specimens were tested for rabies using the Direct Immunofluorescent Antibody Technique (DFAT) and the results compared to those obtained using the indirect avidin-biotin technique using Streptavidin alkaline phosphatase technique and routine haematoxylin eosin (HE) staining for Negri bodies. Fixation in formalin was done for varying lengths of time from 24 to 72 hours. Sections from the paraffin blocks were cut using a sliding microtome at a thickness of 3 micrometers and fished onto clean slides coated with Poly-L-Lysine to avoid detachment during the incubation and rinsing steps. Enzyme digestion using trypsin was applied to sections to unmask antigenic sites concealed during formalin fixation. Fast red TR salt was the chromogen used of the 39 cases tested the DFAT gave positive results in 29 cases and negative results in 10 cases. The immunohistochemical test gave positive results in 25 cases and negative results in 14 cases. The HE staining gave positive results in 16 cases and negative results in 23 cases. Only in one case did the DFAT give a negative result and the immunohistochemical technique give a positive result. Using DFAT as the gold standard, the sensitivity and specificity of the immunohistochemical test and histopathology were calculated. However, these two means of comparison were not sufficient so the level of agreement between the methods was also calculated and a kappa value for each obtained. The sensitivity of the immunohistochemical technique was found to be 82.7%, specificity was 90%. The level of agreement was 85% with a positive predictive value (PPV) of 0.96, and negative predictive value (NPV) of 0.64. The calculated kappa value was 0.64. The histopathological test gave sensitivity of 55.1% and specificity 100%. The level of agreement was 67% with PPV = 1.00, NPV = 0.43. The calculated kappa value was 0.39. It was possible to show that the indirect immunohistochemical technique using Streptavidin alkaline phosphatase can successfully be used to diagnose rabies. This technique is an adjunct to DFAT, and is an alternative in places where it is not possible to keep specimens frozen or to get them to a diagnostic laboratory in a fresh state. Other instances where the immunohistochemical technique can be applied are those where the dark field microscope with an ultraviolet source is not available, or in retrospective studies. It was also shown that trypsin digestion greatly improves the staining quality of the sections. However, digestion beyond 90 minutes was found to result in unacceptable tissue destruction…
Subjects/Keywords: Rabies – Diagnosis;
Rabies Vaccination
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APA (6th Edition):
Kalima-Munalula, M. N. (2012). Utility of immunohistochemical staining technique as a routine tool in Rabies Diagnosis
. (Thesis). University of Zambia. Retrieved from http://hdl.handle.net/123456789/1722
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kalima-Munalula, Mukatimui N. “Utility of immunohistochemical staining technique as a routine tool in Rabies Diagnosis
.” 2012. Thesis, University of Zambia. Accessed February 28, 2021.
http://hdl.handle.net/123456789/1722.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kalima-Munalula, Mukatimui N. “Utility of immunohistochemical staining technique as a routine tool in Rabies Diagnosis
.” 2012. Web. 28 Feb 2021.
Vancouver:
Kalima-Munalula MN. Utility of immunohistochemical staining technique as a routine tool in Rabies Diagnosis
. [Internet] [Thesis]. University of Zambia; 2012. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/123456789/1722.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kalima-Munalula MN. Utility of immunohistochemical staining technique as a routine tool in Rabies Diagnosis
. [Thesis]. University of Zambia; 2012. Available from: http://hdl.handle.net/123456789/1722
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Montana Tech
3.
Lodmell, Donald Louis.
PATHOGENESIS OF ABORTIVE RABIES.
Degree: PhD, 1967, Montana Tech
URL: https://scholarworks.umt.edu/etd/9649
Subjects/Keywords: Rabies.
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APA (6th Edition):
Lodmell, D. L. (1967). PATHOGENESIS OF ABORTIVE RABIES. (Doctoral Dissertation). Montana Tech. Retrieved from https://scholarworks.umt.edu/etd/9649
Chicago Manual of Style (16th Edition):
Lodmell, Donald Louis. “PATHOGENESIS OF ABORTIVE RABIES.” 1967. Doctoral Dissertation, Montana Tech. Accessed February 28, 2021.
https://scholarworks.umt.edu/etd/9649.
MLA Handbook (7th Edition):
Lodmell, Donald Louis. “PATHOGENESIS OF ABORTIVE RABIES.” 1967. Web. 28 Feb 2021.
Vancouver:
Lodmell DL. PATHOGENESIS OF ABORTIVE RABIES. [Internet] [Doctoral dissertation]. Montana Tech; 1967. [cited 2021 Feb 28].
Available from: https://scholarworks.umt.edu/etd/9649.
Council of Science Editors:
Lodmell DL. PATHOGENESIS OF ABORTIVE RABIES. [Doctoral Dissertation]. Montana Tech; 1967. Available from: https://scholarworks.umt.edu/etd/9649
Michigan State University
4.
Elkassaby, Maie H.
A primary goat kidney cell rabies vaccine for human use.
Degree: MS, Department of Animal Science, 1985, Michigan State University
URL: http://etd.lib.msu.edu/islandora/object/etd:21932
Subjects/Keywords: Rabies vaccines; Rabies
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APA (6th Edition):
Elkassaby, M. H. (1985). A primary goat kidney cell rabies vaccine for human use. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:21932
Chicago Manual of Style (16th Edition):
Elkassaby, Maie H. “A primary goat kidney cell rabies vaccine for human use.” 1985. Masters Thesis, Michigan State University. Accessed February 28, 2021.
http://etd.lib.msu.edu/islandora/object/etd:21932.
MLA Handbook (7th Edition):
Elkassaby, Maie H. “A primary goat kidney cell rabies vaccine for human use.” 1985. Web. 28 Feb 2021.
Vancouver:
Elkassaby MH. A primary goat kidney cell rabies vaccine for human use. [Internet] [Masters thesis]. Michigan State University; 1985. [cited 2021 Feb 28].
Available from: http://etd.lib.msu.edu/islandora/object/etd:21932.
Council of Science Editors:
Elkassaby MH. A primary goat kidney cell rabies vaccine for human use. [Masters Thesis]. Michigan State University; 1985. Available from: http://etd.lib.msu.edu/islandora/object/etd:21932
Tampere University
5.
Mäkinen, Lauri.
Vesikauhun saastuttama Suomi: Vesikauhu, sen ehkäisy ja hoito Suomessa 1910-luvulla. Erityistarkastelussa Viipurin lääni.
Degree: 2020, Tampere University
URL: https://trepo.tuni.fi/handle/10024/120334
► Vesikauhu on ikävä tauti, joka ilman oikeanlaista hoitoa tappaa lähes varmasti. Olen tutkinut vesikauhun en-naltaehkäisyä, hoitoa ja kontrollia Suomessa 1910-luvulla. Aikaisemman tutkimuksen mukaan erityisesti Itä-Suomi…
(more)
▼ Vesikauhu on ikävä tauti, joka ilman oikeanlaista hoitoa tappaa lähes varmasti. Olen tutkinut vesikauhun en-naltaehkäisyä, hoitoa ja kontrollia Suomessa 1910-luvulla. Aikaisemman tutkimuksen mukaan erityisesti Itä-Suomi oli vesikauhun riivaamaa seutua, joten olen ottanut lähempään tarkasteluun Viipurin läänin. Olen tar-kastellut vesikauhua myös sosiaalisena ja yhteiskunnallisena ilmiönä. Tutkimuksen lähteet muodostuvat tilas-tomateriaalista (pääasiassa Suomen virallinen tilasto), laeista ja muista valtiollisista aineistoista sekä sanoma- ja aikakauslehdistä. Menetelmänä olen käyttänyt muun muassa kartallistamista, mikä on mahdollistanut taudin levinneisyyden paremman maantieteellisen tarkastelun.
1910-luvun Suomessa vesikauhun leviämistä pyrittiin estämään monin keinoin. Piirieläinlääkärit valvoivat eläintautien esiintymistä ja vesikauhun ilmaantuessa pyysivät läänin kuvernööriä julistamaan alueen vesi-kauhun saastuttamaksi. Saastuneeksi julistetulla alueella lemmikkieläimet tuli pitää kiinni tai koirien kohdalla käyttää kuonokoppaa. Ohjeistusten vastaisesti pidetyt eläimet sai rankkuri tai poliisi tappaa. Koiraverolla yri-tettiin vähentää koirien eli potentiaalisten vesikauhunkantajien määrää. Rankkurit valvoivat myös veron mak-samista ja ottivat veromerkittömät koirat kiinni ja tappoivat ne, jos omistaja ei vaaditussa ajassa ilmaantunut paikalle. Rankkurien menetelmät olivat eläinsuojelun kannalta kyseenalaiset, joten koirien surmaamistapaan pyrittiin puuttumaan. Suuri osa koiranomistajista jätti koiraveron maksamatta eikä kuonokoppaa pidetty aina vaadittaessa.
Vuodesta 1885 lähtien vesikauhua oli mahdollista hoitaa rokotteella. Maailman ensimmäisessä hoitoa tarjoa-vassa Pasteur-laitoksessa Ranskassa kävi hoidettavana yksi ryhmä suomalaisia, minkä jälkeen suomalaiset potilaat hoidettiin Pietarissa. Suomeen perustettiin oma Pasteur-laitos vuonna 1916, minkä ansiosta vesi-kauhun uhrit voitiin hoitaa kotimaassa. Laitoksen kohtaamista ongelmista huolimatta ainoastaan yksi potilas kuoli vuosikymmenen loppuun mennessä. Koko vuosikymmenenä kuoli kaksi muuta suomalaista, joista toinen oli saanut hoitoa Pietarin Pasteur-laitoksessa ja toinen oli jäänyt ilman hoitoa. Eläimiä kuoli vesikauhuun huo-mattavasti enemmän kuin ihmisiä.
Viipurin läänissä vesikauhua esiintyi paljon, mutta 1910-luvun lopulla vesikauhu oli jo yleisempi Uudellamaalla ja Hämeessä kuin Viipurin läänissä. Tautia ilmeni ympäri Suomen Ahvenanmaata ja Lappia lukuun ottamatta. Yleisintä vesikauhu oli etelän väkirikkailla alueilla, joissa myös ihmisten, eläinten ja asioiden liikkuminen oli suurempaa. Aikaisemmasta tulkinnasta poiketen vesikauhu ei keskittynyt Venäjän rajalle, vaikkakin Karjalan kannas oli vesikauhun pahasti saastuttama alue. Tautia ei esiintynyt läänien sisällä tasaisesti. Esimerkiksi Viipurin läänissä oli pahasti vesikauhuisien kuntien vieressä alueita, joissa vesikauhua ei ollut laisinkaan.
Subjects/Keywords: vesikauhu
;
rabies
;
raivotauti
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APA (6th Edition):
Mäkinen, L. (2020). Vesikauhun saastuttama Suomi: Vesikauhu, sen ehkäisy ja hoito Suomessa 1910-luvulla. Erityistarkastelussa Viipurin lääni.
(Masters Thesis). Tampere University. Retrieved from https://trepo.tuni.fi/handle/10024/120334
Chicago Manual of Style (16th Edition):
Mäkinen, Lauri. “Vesikauhun saastuttama Suomi: Vesikauhu, sen ehkäisy ja hoito Suomessa 1910-luvulla. Erityistarkastelussa Viipurin lääni.
” 2020. Masters Thesis, Tampere University. Accessed February 28, 2021.
https://trepo.tuni.fi/handle/10024/120334.
MLA Handbook (7th Edition):
Mäkinen, Lauri. “Vesikauhun saastuttama Suomi: Vesikauhu, sen ehkäisy ja hoito Suomessa 1910-luvulla. Erityistarkastelussa Viipurin lääni.
” 2020. Web. 28 Feb 2021.
Vancouver:
Mäkinen L. Vesikauhun saastuttama Suomi: Vesikauhu, sen ehkäisy ja hoito Suomessa 1910-luvulla. Erityistarkastelussa Viipurin lääni.
[Internet] [Masters thesis]. Tampere University; 2020. [cited 2021 Feb 28].
Available from: https://trepo.tuni.fi/handle/10024/120334.
Council of Science Editors:
Mäkinen L. Vesikauhun saastuttama Suomi: Vesikauhu, sen ehkäisy ja hoito Suomessa 1910-luvulla. Erityistarkastelussa Viipurin lääni.
[Masters Thesis]. Tampere University; 2020. Available from: https://trepo.tuni.fi/handle/10024/120334
Penn State University
6.
Muller, Alison.
Variation in Post Exposure Prophylaxis of Rabies in Patients Presenting with an Animal Exposure to the PennState Hershey Emergency Department.
Degree: 2016, Penn State University
URL: https://submit-etda.libraries.psu.edu/catalog/mw22v5449
► ABSTRACT Rabies infection is caused by the RNA virus, Lyssavirus Rhabdoviridae. Rabies leads among infectious diseases in mortality by victimizing an estimated 40,000 – 60,000…
(more)
▼ ABSTRACT
Rabies infection is caused by the RNA virus, Lyssavirus Rhabdoviridae.
Rabies leads among infectious diseases in mortality by victimizing an estimated 40,000 – 60,000 people globally every year. There is no standard protocol for patients presenting with an animal exposure and suspected
rabies infection to the emergency department. Routine treatment for animal bites includes cleaning and irrigation of the wound, debriding the wound, imaging for residual matter, and suturing followed by a tetanus booster and antibiotics.
Rabies PEP is administered on a case-by-case basis. The Penn State Hershey Medical Center Emergency Department currently issues
rabies post exposure prophylaxis at a rate of eleven times that of the national average of actual cases of
rabies per year. Few studies have been conducted regarding the variation among emergency medicine providers as compared to the Advisory Committee of Immunization Practices. This study aims to detect variation between providers and their adherence to Advisory Committee Immunization Practice guidelines in patients presenting to the Penn State Hershey Medical Center Emergency Department for a complaint of an animal exposure between January 1, 2011 and January 1, 2016. Participant charts were reviewed and data was abstracted according to four collection instruments specific to patient demographics, the involved animal, wound care, and
rabies post exposure prophylaxis compliance. The data was analyzed (n = 400) as a binary outcome variable and the probability of a “yes” event (provider adherence to the ACIP protocol) was estimated along with its 95% confidence interval. Of the 400 patients examined, providers disagreed with the ACIP directives at a rate of 13%, in which an important discrepancy was error in immunoglobulin dosage.
Advisors/Committee Members: Vernon Michael Chinchilli, Thesis Advisor/Co-Advisor, Brian Jeremy Kipe, Committee Member, Kristen H Kjerulff, Committee Member.
Subjects/Keywords: Rabies; emergency medicine; animal bite; rabies post exposure prophylaxis; Rabies Human Immunoglobulin
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APA ·
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APA (6th Edition):
Muller, A. (2016). Variation in Post Exposure Prophylaxis of Rabies in Patients Presenting with an Animal Exposure to the PennState Hershey Emergency Department. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/mw22v5449
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Muller, Alison. “Variation in Post Exposure Prophylaxis of Rabies in Patients Presenting with an Animal Exposure to the PennState Hershey Emergency Department.” 2016. Thesis, Penn State University. Accessed February 28, 2021.
https://submit-etda.libraries.psu.edu/catalog/mw22v5449.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Muller, Alison. “Variation in Post Exposure Prophylaxis of Rabies in Patients Presenting with an Animal Exposure to the PennState Hershey Emergency Department.” 2016. Web. 28 Feb 2021.
Vancouver:
Muller A. Variation in Post Exposure Prophylaxis of Rabies in Patients Presenting with an Animal Exposure to the PennState Hershey Emergency Department. [Internet] [Thesis]. Penn State University; 2016. [cited 2021 Feb 28].
Available from: https://submit-etda.libraries.psu.edu/catalog/mw22v5449.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Muller A. Variation in Post Exposure Prophylaxis of Rabies in Patients Presenting with an Animal Exposure to the PennState Hershey Emergency Department. [Thesis]. Penn State University; 2016. Available from: https://submit-etda.libraries.psu.edu/catalog/mw22v5449
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Pretoria
7.
[No author].
Molecular epidemiology of African mongoose rabies and
Mokola virus
.
Degree: 2010, University of Pretoria
URL: http://upetd.up.ac.za/thesis/available/etd-02192010-155748/
► The African continent sustains a variety of lyssaviruses and this study focused on two of these lyssaviruses that are unique to the continent namely rabies…
(more)
▼ The African continent sustains a variety of
lyssaviruses and this study focused on two of these lyssaviruses
that are unique to the continent namely
rabies virus mongoose
biotype and Mokola virus (MOKV).
Rabies virus (RABV) belongs to
genotype (gt) 1 of the Lyssavirus genus in the family
Rhabdoviridae, order Mononegavirales, while Mokola virus belongs to
gt3 of this genus. Both these viruses cause fatal
rabies
encephalitis in vertebrate animals. Genotype 1 (
rabies virus)
isolates from southern African countries display great genetic
diversity and are grouped into two main biotypes i.e. canid and
mongoose biotypes. Due to the difference in the epidemiology and
pathogenesis of these biotypes, it has been hypothesized that the
two biotypes were introduced into Africa at different times. The
objective was to study the molecular phylogeny of representative
rabies virus isolates of the mongoose biotype, isolated in South
Africa and Zimbabwe over a period of 27 years, towards a better
understanding of the origin of this group. In this study the
complete nucleoprotein (1353 nucleotides) and glycoprotein (1575
nucleotides) genes were sequenced. The evolutionary dynamics of
this virus variant was investigated using Bayesian methodology,
allowing for rate variation among the different viral lineages. The
phylogenetic analysis of this dataset confirms previous findings of
extended evolutionary adaptation of isolates in specific geographic
areas. Furthermore when these isolates are analyzed together with
rabies virus isolates from across the world, they still form an
independent cluster separate from any other African
rabies virus
isolates, thereby hinting towards a separate introduction to the
continent before that of canid
rabies. Molecular clock analysis
estimates the age of the mongoose biotype to be approximately 200
years old, which is in concurrence with literature describing
rabies in mongooses since the early 1800’s. In addition, a
phylogenetic analysis of Mokola virus isolates (gt3) from South
Africa, Zimbabwe, Cameroon and Central African Republic is
described. All the South African isolates before 2008, as well as
most of the Zimbabwean isolates (except isolate 21846) were
included in this analysis. The complete nucleoprotein gene (1353nt)
was amplified and sequenced. Phylogenetic analysis showed virus
grouping to correspond to their geographic location. Further
analysis showed Mokola virus isolates to display genetic diversity
similar to that found in representative gt1 isolates.
Copyright
Advisors/Committee Members: Prof L H Nel (advisor), Dr W Markotter (advisor).
Subjects/Keywords: Mongoose rabies;
Mokola virus;
UCTD
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APA (6th Edition):
author], [. (2010). Molecular epidemiology of African mongoose rabies and
Mokola virus
. (Masters Thesis). University of Pretoria. Retrieved from http://upetd.up.ac.za/thesis/available/etd-02192010-155748/
Chicago Manual of Style (16th Edition):
author], [No. “Molecular epidemiology of African mongoose rabies and
Mokola virus
.” 2010. Masters Thesis, University of Pretoria. Accessed February 28, 2021.
http://upetd.up.ac.za/thesis/available/etd-02192010-155748/.
MLA Handbook (7th Edition):
author], [No. “Molecular epidemiology of African mongoose rabies and
Mokola virus
.” 2010. Web. 28 Feb 2021.
Vancouver:
author] [. Molecular epidemiology of African mongoose rabies and
Mokola virus
. [Internet] [Masters thesis]. University of Pretoria; 2010. [cited 2021 Feb 28].
Available from: http://upetd.up.ac.za/thesis/available/etd-02192010-155748/.
Council of Science Editors:
author] [. Molecular epidemiology of African mongoose rabies and
Mokola virus
. [Masters Thesis]. University of Pretoria; 2010. Available from: http://upetd.up.ac.za/thesis/available/etd-02192010-155748/
University of Namibia
8.
Hikufe, EH.
Rabies sero-survey in vaccinated domestic dogs and knowledge assessment of rabies among dog owners, Ohangwena region, Namibia
.
Degree: 2016, University of Namibia
URL: http://hdl.handle.net/11070/1696
► Rabies kills over 55,000 people worldwide annually of which about 97% die resulting from the bite(s) of rabid dogs. Despite the free annual vaccination of…
(more)
▼ Rabies kills over 55,000 people worldwide annually of which about 97% die
resulting from the bite(s) of rabid dogs. Despite the free annual vaccination of dogs
in Namibia and Ohangwena region in particular, rabies is still on the increase in both animals and humans. We conducted this study to establish the level of protection against rabies in the vaccinated domestic dogs through antibody testing.
Furthermore, the study assessed the level of people’s knowledge on rabies.
A descriptive cross-sectional study design was used. A random sample of 170 sera
was collected from the dogs after one year from the previous vaccination. We tested
sera at the Central Veterinary Laboratory using the BioPro Rabies ELISA test kit
and defined rabies protective antibody titre as titres ≥0.5IU/mL. Data were collected
using a structured questionnaire and analysed using Epi info 7 and Microsoft excel.
Among the 170 dogs, 136 (80%) acquired protective antibody titres (95% CI: 73.2%-85.7%). The majority of samples came from dogs younger than 3 years 90(53%). However, dogs older than 3 years maintained rabies protective antibodies better than the younger dogs (87% versus 74%), Chi2= 4.2, df=1, P=0.04. About 88% of dogs that received repeated vaccinations (boosters) over the years maintained protective antibodies compared to only 74% of dogs that received a single vaccination a year ago without a booster (P= 0.03). Eighty (80%) of the vaccinated dogs maintained protective rabies antibodies. High level of protective antibodies was observed more in older dogs and dogs that received booster vaccinations over the last three years. We recommend rabies vaccination to be conducted twice per year and forceful vaccination be instituted for stray dogs and dogs that are difficult to handle during the campaigns. Cooperation among relevant stakeholders should be instituted to ensure effective rabies control.
Subjects/Keywords: Rabies
;
Dogs
;
Antibodies
;
Vaccination
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APA (6th Edition):
Hikufe, E. (2016). Rabies sero-survey in vaccinated domestic dogs and knowledge assessment of rabies among dog owners, Ohangwena region, Namibia
. (Thesis). University of Namibia. Retrieved from http://hdl.handle.net/11070/1696
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hikufe, EH. “Rabies sero-survey in vaccinated domestic dogs and knowledge assessment of rabies among dog owners, Ohangwena region, Namibia
.” 2016. Thesis, University of Namibia. Accessed February 28, 2021.
http://hdl.handle.net/11070/1696.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hikufe, EH. “Rabies sero-survey in vaccinated domestic dogs and knowledge assessment of rabies among dog owners, Ohangwena region, Namibia
.” 2016. Web. 28 Feb 2021.
Vancouver:
Hikufe E. Rabies sero-survey in vaccinated domestic dogs and knowledge assessment of rabies among dog owners, Ohangwena region, Namibia
. [Internet] [Thesis]. University of Namibia; 2016. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/11070/1696.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hikufe E. Rabies sero-survey in vaccinated domestic dogs and knowledge assessment of rabies among dog owners, Ohangwena region, Namibia
. [Thesis]. University of Namibia; 2016. Available from: http://hdl.handle.net/11070/1696
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Pretoria
9.
Van Zyl, Nicolette.
Molecular
epidemiology of African mongoose rabies and Mokola
virus.
Degree: Microbiology and Plant
Pathology, 2010, University of Pretoria
URL: http://hdl.handle.net/2263/30397
► The African continent sustains a variety of lyssaviruses and this study focused on two of these lyssaviruses that are unique to the continent namely rabies…
(more)
▼ The African continent sustains a variety of lyssaviruses
and this study focused on two of these lyssaviruses that are unique
to the continent namely
rabies virus mongoose biotype and Mokola
virus (MOKV).
Rabies virus (RABV) belongs to genotype (gt) 1 of the
Lyssavirus genus in the family Rhabdoviridae, order
Mononegavirales, while Mokola virus belongs to gt3 of this genus.
Both these viruses cause fatal
rabies encephalitis in vertebrate
animals. Genotype 1 (
rabies virus) isolates from southern African
countries display great genetic diversity and are grouped into two
main biotypes i.e. canid and mongoose biotypes. Due to the
difference in the epidemiology and pathogenesis of these biotypes,
it has been hypothesized that the two biotypes were introduced into
Africa at different times. The objective was to study the molecular
phylogeny of representative
rabies virus isolates of the mongoose
biotype, isolated in South Africa and Zimbabwe over a period of 27
years, towards a better understanding of the origin of this group.
In this study the complete nucleoprotein (1353 nucleotides) and
glycoprotein (1575 nucleotides) genes were sequenced. The
evolutionary dynamics of this virus variant was investigated using
Bayesian methodology, allowing for rate variation among the
different viral lineages. The phylogenetic analysis of this dataset
confirms previous findings of extended evolutionary adaptation of
isolates in specific geographic areas. Furthermore when these
isolates are analyzed together with
rabies virus isolates from
across the world, they still form an independent cluster separate
from any other African
rabies virus isolates, thereby hinting
towards a separate introduction to the continent before that of
canid
rabies. Molecular clock analysis estimates the age of the
mongoose biotype to be approximately 200 years old, which is in
concurrence with literature describing
rabies in mongooses since
the early 1800’s. In addition, a phylogenetic analysis of Mokola
virus isolates (gt3) from South Africa, Zimbabwe, Cameroon and
Central African Republic is described. All the South African
isolates before 2008, as well as most of the Zimbabwean isolates
(except isolate 21846) were included in this analysis. The complete
nucleoprotein gene (1353nt) was amplified and sequenced.
Phylogenetic analysis showed virus grouping to correspond to their
geographic location. Further analysis showed Mokola virus isolates
to display genetic diversity similar to that found in
representative gt1 isolates. Copyright
Advisors/Committee Members: Prof L H Nel (advisor), Dr W Markotter (advisor).
Subjects/Keywords: Mongoose
rabies; Mokola
virus;
UCTD
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APA (6th Edition):
Van Zyl, N. (2010). Molecular
epidemiology of African mongoose rabies and Mokola
virus. (Masters Thesis). University of Pretoria. Retrieved from http://hdl.handle.net/2263/30397
Chicago Manual of Style (16th Edition):
Van Zyl, Nicolette. “Molecular
epidemiology of African mongoose rabies and Mokola
virus.” 2010. Masters Thesis, University of Pretoria. Accessed February 28, 2021.
http://hdl.handle.net/2263/30397.
MLA Handbook (7th Edition):
Van Zyl, Nicolette. “Molecular
epidemiology of African mongoose rabies and Mokola
virus.” 2010. Web. 28 Feb 2021.
Vancouver:
Van Zyl N. Molecular
epidemiology of African mongoose rabies and Mokola
virus. [Internet] [Masters thesis]. University of Pretoria; 2010. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/2263/30397.
Council of Science Editors:
Van Zyl N. Molecular
epidemiology of African mongoose rabies and Mokola
virus. [Masters Thesis]. University of Pretoria; 2010. Available from: http://hdl.handle.net/2263/30397
University of Nairobi
10.
Leelia, Rosamond A.
A survey of animal-bite injuries in humans and the economic burden of rabies in Machakos county, Kenya
.
Degree: 2015, University of Nairobi
URL: http://hdl.handle.net/11295/95226
► This thesis describes a survey of a retrospective and prospective study conducted in Machakos County and the epidemiology of animal-bites in humans in Machakos, Kenya.…
(more)
▼ This thesis describes a survey of a retrospective and prospective study conducted in Machakos County and the epidemiology of animal-bites in humans in Machakos, Kenya. The objectives of the study were: 1) to characterize animal-bite injuries in humans in Machakos County; 2) to estimate the burden of rabies in Machakos County; and 3) to test the application of ‘One Health’ Approach in the control of rabies in the County.
Cases of animal-bites in humans that were reported at the two main district hospitals in the county, namely, Machakos (Level 5) and Kangundo (Level 4) were reviewed. Retrospective data on animal-bites were collected from records kept at the Machakos and Kangundo district veterinary offices and the corresponding district hospitals (2009-2012). Detailed data on animal-bites were collected prospectively for three months (May-July, 2013) at the district veterinary offices and the two hospitals. During 2009-2012, a total of 2636 cases of human bites by animals were reported at the hospitals. Dog bites accounted for the majority (95%; 2505/2636) of the cases. During the same period, only a quarter (25%; 748/2636) of bites cases was reported to the veterinary offices (95%; 710/748 by dogs). From (May –July, 2013), 121 cases were reported at the two hospitals and none at the veterinary offices. Approximately a half (49.5%; 60/121) of the bites was caused by unknown unvaccinated dogs against rabies and 50.5% by dogs of unknown vaccinated status. Some cases came from distant villages in the county including Masinga, Matuu and Ikombe. Data on cases of animal-bites in humans reported to the two hospitals and district veterinary offices were also collected to assess the flow of information between the two ministries responsible for rabies control activities. A huge proportion (88%; 106/121) of the bites victims were not given anti-rabies vaccine sourced from the hospitals and had to purchase it from
xiv
private pharmacies at a price of Ksh 900 per dose. Thirty eight percent (46/121) of the bite cases received only a three-dose vaccination regimen of 1ml of vaccine on days (0, 3, 7), while 27% received a 5-dose regimen of 1ml of vaccine on days (0, 3, 7, 14, 28).
Data were entered and cleaned in MS Excel®. Summary statistics including graphs (bars and pie charts), frequency tables and means were generated using the spreadsheets. Data were then exported to Genstat (15th Edition SP1 Version) for statistical analysis. Chi square statistics was used to determine association between categorical variables in the dataset and the type of animal bite. ANOVA statistics were used to determine mean differences across groups. A p value of < 5% was considered significant. A GIS Programme called GIS Map Info Professional was used to plot graphs showing locations and bites incidences within Machakos County.
In conclusion, this study revealed that the incidence of animal-bites in humans, and therefore the risk of rabies, is high in Machakos County and that the domestic dog is the most important species. Control of rabies is…
Subjects/Keywords: Economic burden of rabies
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Leelia, R. A. (2015). A survey of animal-bite injuries in humans and the economic burden of rabies in Machakos county, Kenya
. (Thesis). University of Nairobi. Retrieved from http://hdl.handle.net/11295/95226
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Leelia, Rosamond A. “A survey of animal-bite injuries in humans and the economic burden of rabies in Machakos county, Kenya
.” 2015. Thesis, University of Nairobi. Accessed February 28, 2021.
http://hdl.handle.net/11295/95226.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Leelia, Rosamond A. “A survey of animal-bite injuries in humans and the economic burden of rabies in Machakos county, Kenya
.” 2015. Web. 28 Feb 2021.
Vancouver:
Leelia RA. A survey of animal-bite injuries in humans and the economic burden of rabies in Machakos county, Kenya
. [Internet] [Thesis]. University of Nairobi; 2015. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/11295/95226.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Leelia RA. A survey of animal-bite injuries in humans and the economic burden of rabies in Machakos county, Kenya
. [Thesis]. University of Nairobi; 2015. Available from: http://hdl.handle.net/11295/95226
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Cambridge
11.
Morters, Michelle.
Improving rabies control in free-roaming dogs.
Degree: PhD, 2014, University of Cambridge
URL: https://www.repository.cam.ac.uk/handle/1810/252882https://www.repository.cam.ac.uk/bitstream/1810/252882/2/license.txt
;
https://www.repository.cam.ac.uk/bitstream/1810/252882/3/Morters%20doctoral%20thesis%202014.pdf.txt
;
https://www.repository.cam.ac.uk/bitstream/1810/252882/6/Morters-2014-PhD.pdf.txt
;
https://www.repository.cam.ac.uk/bitstream/1810/252882/8/Morters-2014-PhD_corrigendum.pdf.txt
;
https://www.repository.cam.ac.uk/bitstream/1810/252882/4/Morters%20doctoral%20thesis%202014.pdf.jpg
;
https://www.repository.cam.ac.uk/bitstream/1810/252882/7/Morters-2014-PhD.pdf.jpg
;
https://www.repository.cam.ac.uk/bitstream/1810/252882/9/Morters-2014-PhD_corrigendum.pdf.jpg
► Canine-mediated rabies is a serious zoonosis responsible for at least 55,000 human deaths every year, primarily in less developed communities in Asia and Africa where…
(more)
▼ Canine-mediated rabies is a serious zoonosis responsible for at least 55,000 human deaths every year, primarily in less developed communities in Asia and Africa where domestic dogs are free-roaming. The disease can be effectively controlled through vaccinating at least 45% of the dogs in a population; however the impact of vaccinations on disease incidence may be affected by dynamic demographic and immunological processes. Specifically, the contribution of these processes, and their regulatory factors, to vaccination coverage and rabies transmission has not been comprehensively estimated. To improve rabies control, through field interventions and epidemiological modelling, more information regarding the effect of these processes, and their regulatory factors, on population and disease dynamics and vaccinal responses was needed. This required a multifaceted approach, using techniques from the fields of population ecology, vaccine-immunology, social science and epidemiological modelling. Demographic data were collected from four populations of free-roaming domestic dogs, two in South Africa and two in Indonesia where rabies is endemic. Longitudinal, individual-level data were obtained by direct observation and surveys, and community-level data by participatory methods. Longitudinal, serological data were collected from three cohorts within the populations. Epidemiological models were based on epidemic theory and empirical data from this current study and previous studies.
A wide array of data were generated relevant to planning rabies control programmes, however of particular importance was evidence regarding positive and negative the impacts of human factors on population and disease dynamics. Nearly all of the dogs were owned, despite being free-roaming, and were accessible for vaccination through their owners; and population size was regulated through human demand for dogs and a substantial fraction of dogs was acquired from outside the communities. These translocated dogs may contribute to the spread of rabies, necessitating widespread and sustained vaccination programmes. Considerable differences in the handleability of dogs between locations and, thus ease of vaccine delivery, may also be attributable to differences in human-dog interactions. Finally, a critical review of the literature, and evaluation of epidemiological models, suggests that human interference in the transmission processes may reduce the incidence of rabies and vaccination threshold.
This study has provided specific evidence that human behaviours are likely to be critically important in relation to the transmission and control of canine-mediated rabies – and is the first to properly identify this. Further detailed studies are required to explore these behaviours and how they vary culturally and geographically. In addition, the results highlight the critical role that demographic processes more generally, as well as immunological decay, play in influencing the long term success of rabies vaccination programmes. Overall, this research…
Subjects/Keywords: Rabies control; Dog; Canine
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APA (6th Edition):
Morters, M. (2014). Improving rabies control in free-roaming dogs. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/252882https://www.repository.cam.ac.uk/bitstream/1810/252882/2/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/252882/3/Morters%20doctoral%20thesis%202014.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/252882/6/Morters-2014-PhD.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/252882/8/Morters-2014-PhD_corrigendum.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/252882/4/Morters%20doctoral%20thesis%202014.pdf.jpg ; https://www.repository.cam.ac.uk/bitstream/1810/252882/7/Morters-2014-PhD.pdf.jpg ; https://www.repository.cam.ac.uk/bitstream/1810/252882/9/Morters-2014-PhD_corrigendum.pdf.jpg
Chicago Manual of Style (16th Edition):
Morters, Michelle. “Improving rabies control in free-roaming dogs.” 2014. Doctoral Dissertation, University of Cambridge. Accessed February 28, 2021.
https://www.repository.cam.ac.uk/handle/1810/252882https://www.repository.cam.ac.uk/bitstream/1810/252882/2/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/252882/3/Morters%20doctoral%20thesis%202014.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/252882/6/Morters-2014-PhD.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/252882/8/Morters-2014-PhD_corrigendum.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/252882/4/Morters%20doctoral%20thesis%202014.pdf.jpg ; https://www.repository.cam.ac.uk/bitstream/1810/252882/7/Morters-2014-PhD.pdf.jpg ; https://www.repository.cam.ac.uk/bitstream/1810/252882/9/Morters-2014-PhD_corrigendum.pdf.jpg.
MLA Handbook (7th Edition):
Morters, Michelle. “Improving rabies control in free-roaming dogs.” 2014. Web. 28 Feb 2021.
Vancouver:
Morters M. Improving rabies control in free-roaming dogs. [Internet] [Doctoral dissertation]. University of Cambridge; 2014. [cited 2021 Feb 28].
Available from: https://www.repository.cam.ac.uk/handle/1810/252882https://www.repository.cam.ac.uk/bitstream/1810/252882/2/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/252882/3/Morters%20doctoral%20thesis%202014.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/252882/6/Morters-2014-PhD.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/252882/8/Morters-2014-PhD_corrigendum.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/252882/4/Morters%20doctoral%20thesis%202014.pdf.jpg ; https://www.repository.cam.ac.uk/bitstream/1810/252882/7/Morters-2014-PhD.pdf.jpg ; https://www.repository.cam.ac.uk/bitstream/1810/252882/9/Morters-2014-PhD_corrigendum.pdf.jpg.
Council of Science Editors:
Morters M. Improving rabies control in free-roaming dogs. [Doctoral Dissertation]. University of Cambridge; 2014. Available from: https://www.repository.cam.ac.uk/handle/1810/252882https://www.repository.cam.ac.uk/bitstream/1810/252882/2/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/252882/3/Morters%20doctoral%20thesis%202014.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/252882/6/Morters-2014-PhD.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/252882/8/Morters-2014-PhD_corrigendum.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/252882/4/Morters%20doctoral%20thesis%202014.pdf.jpg ; https://www.repository.cam.ac.uk/bitstream/1810/252882/7/Morters-2014-PhD.pdf.jpg ; https://www.repository.cam.ac.uk/bitstream/1810/252882/9/Morters-2014-PhD_corrigendum.pdf.jpg
University of Cape Town
12.
Katz, Woolf.
Rabies virus soluble antigens : a biochemical and biophysical study of the major antigen of rabies virus.
Degree: Image, Division of Virology, 1967, University of Cape Town
URL: http://hdl.handle.net/11427/24952
► The purpose of these investigations was to isolate and purify the largest of several antigens demonstrable in rabies-infected suckling mouse brains. The biochemical and biophysical…
(more)
▼ The purpose of these investigations was to isolate and purify the largest of several antigens demonstrable in
rabies-infected suckling mouse brains. The biochemical and biophysical properties of the antigen were studied with a view to elucidating its contribution to the intracellular synthesis and the structure of the virus particles. Extracts of normal and infected suckling mouse brains were purified by precipitation at pH 4.5 and freed of the smaller antigens by centrifugation prior to digestion with RNAase, DNAase and trypsin. The large antigen was purified by enzyme treatment, preparative ultracentrifugation, exclusion chroma tography and gradient centrifugation and appeared as rings varying in diameter between 8 and 12 mμ when examined by electron microscopy. Methods for the chemical estimation of pentose, deoxypentose and nitrogen were modified to meet the requirements of this investigation, and these techniques were used to determine the composition of the purified antigen. The antigen is a ribonucleoprotein, and found to be resistant to RNAase, DNAase, trypsin and chymotrypsin. A purified solution of the antigen contained 7.3μg RNA/ml., 11.4μg protein/ml and probably a trace of DNA. The success of this programme has resulted in the accumulation of certain original information which has been used in clari£ying the nature and structure of the largest soluble antigen.
Advisors/Committee Members: Mead, T H (advisor).
Subjects/Keywords: Rabies virus; Rabies vaccine; Rabies virus~Rabies vaccine; Antigens
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MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Katz, W. (1967). Rabies virus soluble antigens : a biochemical and biophysical study of the major antigen of rabies virus. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/24952
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Katz, Woolf. “Rabies virus soluble antigens : a biochemical and biophysical study of the major antigen of rabies virus.” 1967. Thesis, University of Cape Town. Accessed February 28, 2021.
http://hdl.handle.net/11427/24952.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Katz, Woolf. “Rabies virus soluble antigens : a biochemical and biophysical study of the major antigen of rabies virus.” 1967. Web. 28 Feb 2021.
Vancouver:
Katz W. Rabies virus soluble antigens : a biochemical and biophysical study of the major antigen of rabies virus. [Internet] [Thesis]. University of Cape Town; 1967. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/11427/24952.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Katz W. Rabies virus soluble antigens : a biochemical and biophysical study of the major antigen of rabies virus. [Thesis]. University of Cape Town; 1967. Available from: http://hdl.handle.net/11427/24952
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Michigan State University
13.
Gauthier, Robert J.
Studies on the purification of rabies vaccine derived from rabbit brain.
Degree: PhD, 1956, Michigan State University
URL: http://etd.lib.msu.edu/islandora/object/etd:40277
Subjects/Keywords: Rabies – Vaccination
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APA ·
Chicago ·
MLA ·
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Export
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APA (6th Edition):
Gauthier, R. J. (1956). Studies on the purification of rabies vaccine derived from rabbit brain. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:40277
Chicago Manual of Style (16th Edition):
Gauthier, Robert J. “Studies on the purification of rabies vaccine derived from rabbit brain.” 1956. Doctoral Dissertation, Michigan State University. Accessed February 28, 2021.
http://etd.lib.msu.edu/islandora/object/etd:40277.
MLA Handbook (7th Edition):
Gauthier, Robert J. “Studies on the purification of rabies vaccine derived from rabbit brain.” 1956. Web. 28 Feb 2021.
Vancouver:
Gauthier RJ. Studies on the purification of rabies vaccine derived from rabbit brain. [Internet] [Doctoral dissertation]. Michigan State University; 1956. [cited 2021 Feb 28].
Available from: http://etd.lib.msu.edu/islandora/object/etd:40277.
Council of Science Editors:
Gauthier RJ. Studies on the purification of rabies vaccine derived from rabbit brain. [Doctoral Dissertation]. Michigan State University; 1956. Available from: http://etd.lib.msu.edu/islandora/object/etd:40277
University of Georgia
14.
LIU, PINGHUA.
Rabies virus N, P and RNA interactions in vivo and mapping the functional domains of N in N-P and N-N interactions.
Degree: 2014, University of Georgia
URL: http://hdl.handle.net/10724/21889
► Rabies virus (RV) nucleoprotein (N) is a multifunctional protein that plays a central role in viral RNA transcription and replication. Its functions require interactions with…
(more)
▼ Rabies virus (RV) nucleoprotein (N) is a multifunctional protein that plays a central role in viral RNA transcription and replication. Its functions require interactions with itself and with other viral components. In vitro studies indicated
that rabies virus phosphoprotein (P), by interacting with the nucleoprotein (N), confers the specificity of genomic RNA encapsidation by N. In this study, the interactions among N, P, and the RNA was examined in virus-infected cells as well as in
transfected cells. When N is expressed alone, it binds to non-specific RNA, particularly the N mRNA. When N and P are co-expressed, the N and P form N-P complexes that do not bind to any RNA. When the N and P are co-expressed together with the
minigenomic RNA, the N-P complexes preferentially bind to the mini-genomic RNA. This demonstrated that indeed RV P, by binding to N, confers the specificity of genomic RNA encapsidation by N in vivo. Furthermore, we investigated the role of N
phosphorylation in the N, P, and RNA interactions. It was found that only the N that bound to RNA was phosphorylated while the N in the N-P complex prior to RNA encapsidation was not, suggesting that RV P, by binding to nascent N, prevents the immediate
phosphorylation of the de novo-synthesized N. However, mutation at the phosphorylation site of the N did not alter the pattern of N-P and NRNA interactions, indicating that N phosphorylation per se does not play a direct role in the N-P interaction and
RNA encapsidation. Nevertheless, the fact that N is not phosphorylated prior to RNA encapsidation may suggest that RV P, by binding to N, keeps the N in a unique conformation for specific encapsidation of the genomic RNA. In order to understand the
detailed N-P and N-N interactions, a series of terminal and internal deletion mutants of the N were constructed and attempts were made to map the domains on N that are involved in these interactions. It was determined that a central region of the N from
amino acids 150 to 285 and a C-terminal region of 360-420 are important for the N-P interactions. Deletion of these regions abolished its ability to bind to P. For self aggregation, amino acids 25 to 30 are required because deletion of the first 25 amino
acids did not affect the N-N interactions. However, deletion of the first 30 amino acids completely abolished the ability of N to self-aggregate. However, none of these mutants supported the transcription and/or replication of the minigenomic RNA.
Together these data suggest that although different domains on the N are involved in N-N and N-P interactions, the full-length N is absolutely required for optimal viral transcription and replication.
Subjects/Keywords: Rabies virus; Nucleoprotein; Phosphoprotein; RNA
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APA (6th Edition):
LIU, P. (2014). Rabies virus N, P and RNA interactions in vivo and mapping the functional domains of N in N-P and N-N interactions. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/21889
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
LIU, PINGHUA. “Rabies virus N, P and RNA interactions in vivo and mapping the functional domains of N in N-P and N-N interactions.” 2014. Thesis, University of Georgia. Accessed February 28, 2021.
http://hdl.handle.net/10724/21889.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
LIU, PINGHUA. “Rabies virus N, P and RNA interactions in vivo and mapping the functional domains of N in N-P and N-N interactions.” 2014. Web. 28 Feb 2021.
Vancouver:
LIU P. Rabies virus N, P and RNA interactions in vivo and mapping the functional domains of N in N-P and N-N interactions. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/10724/21889.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
LIU P. Rabies virus N, P and RNA interactions in vivo and mapping the functional domains of N in N-P and N-N interactions. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/21889
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Massey University
15.
Wangmo, Karma.
Comparison of antibody titres between intradermal and intramuscular rabies vaccination using inactivated vaccine in cattle in Bhutan.
Degree: Master of Veterinary Science, 2018, Massey University
URL: http://hdl.handle.net/10179/13379
► In developing countries, the cost of vaccination limits the use of prophylactic rabies vaccination, especially in cattle. Intradermal vaccination delivers antigen directly to an area…
(more)
▼ In developing countries, the cost of vaccination limits the use of prophylactic rabies vaccination, especially in cattle. Intradermal vaccination delivers antigen directly to an area with higher number of antigen-presenting cells. Therefore, it can produce equivalent or higher antibody titres than conventional intramuscular vaccination even when a lower dose is given.
This study aimed to compare the antibody response in cattle vaccinated intramuscularly with 1mL of inactivated rabies vaccine (Raksharab, Indian Immunologicals) against intradermally vaccinated cattle with 0.2mL of the same vaccine. The study was conducted in Haa province of Bhutan where rabies is not endemic. One hundred cattle from 27 farms were selected for the study. Virus neutralising antibody (VNA) response was measured using the fluorescent antibody virus neutralisation test on the day of vaccination (day 0) and 14, 30, 60 and 90 days later.
Overall, 71% of intradermally vaccinated cattle and 89% of the intramuscularly vaccinated cattle produced a protective response (≥0.5IU/mL). This difference was significant (P<0.02) on days 14 and 30 post vaccination with 36 and 56% in the intradermal group having titres ≥0.5 IU/mL respectively compared to the equivalent figures of 78 and 76% in the intramuscular group. The mean VNA titres were lower for intradermal group than intramuscular group (p<0.001) with the mean difference being greater than 0.6 IU/mL. Although low dose intradermal vaccination did produce a detectable antibody response, it was inferior to intramuscular vaccination. Thus, although, intradermal vaccination has the potential to reduce the cost of vaccination by reducing the dose required, this study showed that a single dose of 0.2mL intradermally was inferior to an intramuscular dose of 1mL. Further research evaluating dose and dose regimen is needed before intradermal vaccination using the Raksharab rabies vaccine can be recommended in cattle.
Subjects/Keywords: Cattle;
Rabies;
Vaccination;
Bhutan
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APA ·
Chicago ·
MLA ·
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CSE |
Export
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APA (6th Edition):
Wangmo, K. (2018). Comparison of antibody titres between intradermal and intramuscular rabies vaccination using inactivated vaccine in cattle in Bhutan. (Masters Thesis). Massey University. Retrieved from http://hdl.handle.net/10179/13379
Chicago Manual of Style (16th Edition):
Wangmo, Karma. “Comparison of antibody titres between intradermal and intramuscular rabies vaccination using inactivated vaccine in cattle in Bhutan.” 2018. Masters Thesis, Massey University. Accessed February 28, 2021.
http://hdl.handle.net/10179/13379.
MLA Handbook (7th Edition):
Wangmo, Karma. “Comparison of antibody titres between intradermal and intramuscular rabies vaccination using inactivated vaccine in cattle in Bhutan.” 2018. Web. 28 Feb 2021.
Vancouver:
Wangmo K. Comparison of antibody titres between intradermal and intramuscular rabies vaccination using inactivated vaccine in cattle in Bhutan. [Internet] [Masters thesis]. Massey University; 2018. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/10179/13379.
Council of Science Editors:
Wangmo K. Comparison of antibody titres between intradermal and intramuscular rabies vaccination using inactivated vaccine in cattle in Bhutan. [Masters Thesis]. Massey University; 2018. Available from: http://hdl.handle.net/10179/13379
University of Cambridge
16.
Morters, Michelle.
Improving rabies control in free-roaming dogs.
Degree: PhD, 2014, University of Cambridge
URL: https://doi.org/10.17863/CAM.16361
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.675895
► Canine-mediated rabies is a serious zoonosis responsible for at least 55,000 human deaths every year, primarily in less developed communities in Asia and Africa where…
(more)
▼ Canine-mediated rabies is a serious zoonosis responsible for at least 55,000 human deaths every year, primarily in less developed communities in Asia and Africa where domestic dogs are free-roaming. The disease can be effectively controlled through vaccinating at least 45% of the dogs in a population; however the impact of vaccinations on disease incidence may be affected by dynamic demographic and immunological processes. Specifically, the contribution of these processes, and their regulatory factors, to vaccination coverage and rabies transmission has not been comprehensively estimated. To improve rabies control, through field interventions and epidemiological modelling, more information regarding the effect of these processes, and their regulatory factors, on population and disease dynamics and vaccinal responses was needed. This required a multifaceted approach, using techniques from the fields of population ecology, vaccine-immunology, social science and epidemiological modelling. Demographic data were collected from four populations of free-roaming domestic dogs, two in South Africa and two in Indonesia where rabies is endemic. Longitudinal, individual-level data were obtained by direct observation and surveys, and community-level data by participatory methods. Longitudinal, serological data were collected from three cohorts within the populations. Epidemiological models were based on epidemic theory and empirical data from this current study and previous studies. A wide array of data were generated relevant to planning rabies control programmes, however of particular importance was evidence regarding positive and negative the impacts of human factors on population and disease dynamics. Nearly all of the dogs were owned, despite being free-roaming, and were accessible for vaccination through their owners; and population size was regulated through human demand for dogs and a substantial fraction of dogs was acquired from outside the communities. These translocated dogs may contribute to the spread of rabies, necessitating widespread and sustained vaccination programmes. Considerable differences in the handleability of dogs between locations and, thus ease of vaccine delivery, may also be attributable to differences in human-dog interactions. Finally, a critical review of the literature, and evaluation of epidemiological models, suggests that human interference in the transmission processes may reduce the incidence of rabies and vaccination threshold. This study has provided specific evidence that human behaviours are likely to be critically important in relation to the transmission and control of canine-mediated rabies ? and is the first to properly identify this. Further detailed studies are required to explore these behaviours and how they vary culturally and geographically. In addition, the results highlight the critical role that demographic processes more generally, as well as immunological decay, play in influencing the long term success of rabies vaccination programmes. Overall, this research has provided…
Subjects/Keywords: 636.089; Rabies control; Dog; Canine
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APA (6th Edition):
Morters, M. (2014). Improving rabies control in free-roaming dogs. (Doctoral Dissertation). University of Cambridge. Retrieved from https://doi.org/10.17863/CAM.16361 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.675895
Chicago Manual of Style (16th Edition):
Morters, Michelle. “Improving rabies control in free-roaming dogs.” 2014. Doctoral Dissertation, University of Cambridge. Accessed February 28, 2021.
https://doi.org/10.17863/CAM.16361 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.675895.
MLA Handbook (7th Edition):
Morters, Michelle. “Improving rabies control in free-roaming dogs.” 2014. Web. 28 Feb 2021.
Vancouver:
Morters M. Improving rabies control in free-roaming dogs. [Internet] [Doctoral dissertation]. University of Cambridge; 2014. [cited 2021 Feb 28].
Available from: https://doi.org/10.17863/CAM.16361 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.675895.
Council of Science Editors:
Morters M. Improving rabies control in free-roaming dogs. [Doctoral Dissertation]. University of Cambridge; 2014. Available from: https://doi.org/10.17863/CAM.16361 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.675895
University of Sydney
17.
Mustiana, Ana.
Assessment of the risk for rabies introduction and establishment in Lombok, Indonesia
.
Degree: 2013, University of Sydney
URL: http://hdl.handle.net/2123/10468
► Rabies, a zoonotic disease, is maintained in the domestic dog population in Indonesia and has caused human fatalities since its introduction to this country in…
(more)
▼ Rabies, a zoonotic disease, is maintained in the domestic dog population in Indonesia and has caused human fatalities since its introduction to this country in the 1880s. Although rabies control strategies have been implemented on rabies-infected islands, this disease is still spreading to other parts of Indonesia, with newly infected islands as recent as 2012. Live dog movement on fishing or cargo boats is believed to have facilitated the introduction of rabies virus into previously rabies-free islands in Indonesia, such as to Bali and Flores. Until today, of the total 33 provinces, only nine provinces remain rabies-free including Lombok Island in West Nusa Tenggara (NTB) Province. This research was conducted from 2011 to 2013 to investigate pathways for rabies entry to Lombok Island via dog movement and to assess the probability of rabies entry and exposure to the susceptible dog population on Lombok. Further, this research aimed to provide knowledge of the pathways and probability of rabies entry to Lombok in order to inform development of quarantine and surveillance strategies to prevent rabies entry and establishment on Lombok. Pathways for rabies entry to Lombok were first defined based on the literature and then refined and prioritised based on expert opinion. After this process, two pathways of release of a rabiesinfected dog were identified: boat and ferry pathways. Scenario trees were developed for each pathway to describe the release of a rabies-infected dog to Lombok, as well as scenario trees to describe the exposure of a rabies-infected dog to the susceptible dog population on Lombok. Four surveys were conducted on Bali and Lombok islands to obtain data used to refine the pathways and to inform the release and exposure models. The first survey obtained data on dog numbers and dog management practices of dog owning households belonging to different ethnic groups at an urban site and a rural site on Lombok. A total of 400 households were interviewed, 300 at the urban site and 100 at the rural site. The majority of the interviewed households belonged to Balinese ethnic group. Sasakese households owning dogs were more frequent at the rural site compared to the urban site. Owning dogs born on Lombok was common (96% households), however, 4% of households reported owning dogs obtained from outside Lombok (Bali and Java). The latter was more common at the urban site and among Balinese ethnic group. All households that reported imported dogs mentionedtransporting the dog/s in a vehicle by ferry from Padang Bai harbour Bali to Lembar harbour Lombok. All these households also reported that the imported dogs did not have the documentation required by the quarantine agency and 11 reported that the imported dogs had been vaccinated but were not able to identify the type of vaccination. The dog owning households kept their dogs either fully restricted, semifree roaming or free-roaming but full restriction was reported only at the urban site. Dog bite cases were reported to be higher at the urban site. For the second…
Subjects/Keywords: Rabies;
Zoonotic disease;
Dogs
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APA ·
Chicago ·
MLA ·
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Export
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Manager
APA (6th Edition):
Mustiana, A. (2013). Assessment of the risk for rabies introduction and establishment in Lombok, Indonesia
. (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/10468
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mustiana, Ana. “Assessment of the risk for rabies introduction and establishment in Lombok, Indonesia
.” 2013. Thesis, University of Sydney. Accessed February 28, 2021.
http://hdl.handle.net/2123/10468.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mustiana, Ana. “Assessment of the risk for rabies introduction and establishment in Lombok, Indonesia
.” 2013. Web. 28 Feb 2021.
Vancouver:
Mustiana A. Assessment of the risk for rabies introduction and establishment in Lombok, Indonesia
. [Internet] [Thesis]. University of Sydney; 2013. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/2123/10468.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mustiana A. Assessment of the risk for rabies introduction and establishment in Lombok, Indonesia
. [Thesis]. University of Sydney; 2013. Available from: http://hdl.handle.net/2123/10468
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Sydney
18.
Tenzin.
Studies on the epidemiology and control of rabies in Bhutan
.
Degree: 2012, University of Sydney
URL: http://hdl.handle.net/2123/10489
► Rabies, a fatal and neglected zoonotic disease, is reported mainly from the southern parts of Bhutan bordering India, but sporadic occurrences have been reported in…
(more)
▼ Rabies, a fatal and neglected zoonotic disease, is reported mainly from the southern parts of Bhutan bordering India, but sporadic occurrences have been reported in other, previously free areas. Domestic dogs play a principal role in the transmission of rabies and no wildlife rabies cases have been reported so far in Bhutan. Although rabies has been endemic and causes substantial financial losses, no detailed studies have been conducted to understand the epidemiology of rabies in Bhutan. The overall objective of this research was to better understand the epidemiology of animal and human rabies and estimate the cost of various rabies intervention measures in humans and animals. This was the first epidemiologic research on rabies ever conducted in Bhutan. Rabies surveillance data (1996 to 2009) and field surveys were used for this epidemiologic research. The spatial and temporal distribution of animal rabies cases was examined by using a Geographic Information System and time series analysis approaches. The study showed that 59 of the 205 sub-districts in Bhutan reported animal rabies from 1996 to 2009 with increased incidences in the four districts in southern parts of Bhutan. Significant (P<0.05) clusters of cases were observed in south central and south west Bhutan. More cases were reported in cattle (n=447) and domestic dogs (n=317) and a significant cross correlation between the number of reported cases in dogs and other domestic animals was demonstrated, wherein the report of cases in dogs predicted cases in other domestic animals. Rabies cases were reported throughout the year with more reports during spring and summer months, likely to be associated with the breeding season of dogs. The annual patterns of cases were relatively stable until 2005, but increased in 2006 and 2008. This increased incidence was associated with re-emergence of rabies in eastern and south west Bhutan between 2005 and 2008, areas that had been previously free from rabies. This major rabies outbreak in eastern Bhutan resulted in one human and 256 domestic animal deaths while the outbreak in south west Bhutan resulted in 97 animal deaths; both outbreaks caused serious financial losses to society. During these outbreaks, large numbers of people (~2000) were directly or indirectly exposed to either suspected rabid animals or animal products derived from rabid animals and were given post-exposure prophylaxis. The outbreak in eastern Bhutan was believed to have been due to an incursion from across the border while local spread from the endemic areas or an incursion was hypothesized in the south-west Bhutan outbreak. The high densities and movements of stray dogs with inadequate control measures were responsible for the rapid spread and persistence of the infection for about two years (from May 2005 to November 2007) in eastern Bhutan. In contrast, the outbreak in south west Bhutan during 2008 was controlled within six months by culling of stray dogs, mass dog vaccination, and impounding of dogs. Anthropogenic factors − including human…
Subjects/Keywords: rabies;
zoonotic disease;
dogs
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APA ·
Chicago ·
MLA ·
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Export
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Manager
APA (6th Edition):
Tenzin. (2012). Studies on the epidemiology and control of rabies in Bhutan
. (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/10489
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Tenzin. “Studies on the epidemiology and control of rabies in Bhutan
.” 2012. Thesis, University of Sydney. Accessed February 28, 2021.
http://hdl.handle.net/2123/10489.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Tenzin. “Studies on the epidemiology and control of rabies in Bhutan
.” 2012. Web. 28 Feb 2021.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Vancouver:
Tenzin. Studies on the epidemiology and control of rabies in Bhutan
. [Internet] [Thesis]. University of Sydney; 2012. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/2123/10489.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Tenzin. Studies on the epidemiology and control of rabies in Bhutan
. [Thesis]. University of Sydney; 2012. Available from: http://hdl.handle.net/2123/10489
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
Kwame Nkrumah University of Science and Technology
19.
Oscar, Vetsi.
Knowledge, attitude, perception and practices in respect of rabies disease among the residents in Ga East municipality, Ghana.
Degree: 2020, Kwame Nkrumah University of Science and Technology
URL: http://dspace.knust.edu.gh:8080/jspui/handle/123456789/13190
► Background: IRabies Iis Ione Iof Ithe Ineglected Itropical Izoonotic Idiseases Icaused Iby Ia Ivirus. IIt IbelongsIto Ithe IRhabdoviridae I(Zachary, I2007). IIt IisIa Idisease Ithat IisIcommonlyIfound…
(more)
▼ Background: IRabies Iis Ione Iof Ithe Ineglected Itropical Izoonotic Idiseases Icaused Iby Ia Ivirus. IIt
IbelongsIto Ithe IRhabdoviridae I(Zachary, I2007). IIt IisIa Idisease Ithat IisIcommonlyIfound Iin Ianimals
Ibut Ican Ieasily Ieffect Ihuman I(Quinn Iet Ial., I2002). IWhere Ithere Iare Ianimal Ireservoirs, Irabies Iis
Icommonly Ispread. IThe IGeneral Iobjective Iof Ithis Istudy Ito Ievaluate Idifferences Iin Iknowledge,
IattitudeIandIperceptionIabout Irabies, IamongItheIresidenceIinIGaIEast I
Method: IA Icross-sectional Istudy Iwas Iused Iin Ithis Istudy Iusing Ipurposive Isampling Itechnics. I I
IData IwasIbe Icollected Iby Iinterviewing Istudy IparticipantsIwith Iquestionnaire Iand Ianalysed Iusing
IOKDICollectionIandIalsoISTATAIversion14.2
Results: IA Itotal Iof I475 Irespondents Iwere Iinvolved Iin Ithe Istudy. IOut Iof I475 Irespondents I354
Irepresenting I74.53%Iwere ImalesIwhile I25.47 Iwere Ifemales. IForIthe IcategoriesIofIdog Iownership
IandIpurposeIofIkeepingIdogs, Iout IofItheI475Irespondents, I444IrepresentingI93.47%IownIdogsIand
Ionly I6.53% Iin Ithe Istudy Iareas Idid Inot Iown Idogs. IAssessing Ithe Ipurpose Iof Ikeeping Idogs, Ithe
Imajority I[348 I(77.25)] Iwere Iof Ithe Iview Ithat Ithey Ikeep Idogs Iof Isecurity Ireasons Iwhile Iothers
Iwere Ialso IofIthe Iopinion Ithat, IdogsIkeepsIthemIcompany Iand, Ithey Ikeep IthemIbecause IofIhaving
Ifun Iwith Ithem. ILessIthan I50% Iof Ithe IrespondentsI[186 I(39.16%)] Iwere Iof Ithe Iview Ithat Ibuying
Imedicine IfromIthe IdrugIstore IisIthe Ifirst IremedyIto Itake IafterIdogIbitsIexposure. IOthersI(29.05%)
Ialso Iwere Iof Itheir Iopinion Ithat ItetanusIvaccination Ishould Ibe Idone Ifirst. IMeanwhile, Icalling Ithe
IdoctorI(12.84%)IandIthoroughlyIwashingItheIwoundIwithIsoapIunderIrunningIwaterI(8.84%)Iseen
IlessIresponses.
Conclusion: IFindingsIfromIthisIstudyIhave Irevealed Ithat Idog IownersIdo Inot Iprovide Ihousing Ifor
ItheirIdogsIand Ido Inot Ifeed Ithem, IthisIcan Ilead Ito Ia Isituation Iwhich IincreasesIthe InumberIofIstray
IdogsIon Ithe Istreet-Iwhich Iare Imore Iat Irisk IofIbeing Ibitten Iby Irabid Idogs, IthusIposing IasIa Isource
III
IofIinfection Ito Ihumans. INot IseekingImedical Ihelp IforIdogsIand IbeatingIthemIare IunfairItreatment
IforItheseIanimals.
A thesis submitted to the School of Public Health, College of Health Sciences, in partial fulfilment of the requirement for the award of a Bachelor Degree and Public Health, September, 2019
KNUST
Subjects/Keywords: Rabies disease; Ga East
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APA ·
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MLA ·
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Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Oscar, V. (2020). Knowledge, attitude, perception and practices in respect of rabies disease among the residents in Ga East municipality, Ghana. (Thesis). Kwame Nkrumah University of Science and Technology. Retrieved from http://dspace.knust.edu.gh:8080/jspui/handle/123456789/13190
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Oscar, Vetsi. “Knowledge, attitude, perception and practices in respect of rabies disease among the residents in Ga East municipality, Ghana.” 2020. Thesis, Kwame Nkrumah University of Science and Technology. Accessed February 28, 2021.
http://dspace.knust.edu.gh:8080/jspui/handle/123456789/13190.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Oscar, Vetsi. “Knowledge, attitude, perception and practices in respect of rabies disease among the residents in Ga East municipality, Ghana.” 2020. Web. 28 Feb 2021.
Vancouver:
Oscar V. Knowledge, attitude, perception and practices in respect of rabies disease among the residents in Ga East municipality, Ghana. [Internet] [Thesis]. Kwame Nkrumah University of Science and Technology; 2020. [cited 2021 Feb 28].
Available from: http://dspace.knust.edu.gh:8080/jspui/handle/123456789/13190.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Oscar V. Knowledge, attitude, perception and practices in respect of rabies disease among the residents in Ga East municipality, Ghana. [Thesis]. Kwame Nkrumah University of Science and Technology; 2020. Available from: http://dspace.knust.edu.gh:8080/jspui/handle/123456789/13190
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
20.
Dallora, Andrea Magalhães Barbosa.
Estudo da ocorrência de casos confirmados de raiva bovina no município de Guaxupé, Minas Gerais.
Degree: Mestrado, Saúde na Comunidade, 2007, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/17/17139/tde-17032008-140516/
;
► A raiva bovina continua sendo uma importante zoonose. A ocorrência de casos confirmados da doença no meio rural é um problema atual de saúde pública,…
(more)
▼ A raiva bovina continua sendo uma importante zoonose. A ocorrência de casos confirmados da doença no meio rural é um problema atual de saúde pública, sendo mais relevante quando se consideram os casos de raiva huma na que ocorreram nos últimos anos no país. Este projeto teve por objetivo estudar a situação da raiva bovina no município de Guaxupé - MG, consideran do: a presença do morcego hematófago no município; o nível de conhecimento dos produtores/empregados rurais sobre a raiva; a vacinação contra a raiva bovina; a notificação de casos da doença junto ao Instituto Mineiro Agro pecuário (IMA); os casos confirmados de raiva animal. Quanto à metodologia, fo ram realizados: um levantamento de dados secundários junto ao IMA e junto à Vigilância Epidemiológica da Gerência Regional de Alfenas - MG, da qual faz parte o município de Guaxupé; a apli cação de um questionário sobre a raiva bovina junto a uma amostra de produtores/empregados rurais do município. Foi feita uma estratificação da amostra em dois grupos, sendo o questionário aplicado em 35 pequenas e médias propriedades e em cinco grandes propriedades. De acordo com os dados do IMA, durante o período de 1999 a 2003, foram realizados 34 exames laboratoriais para diagnóstico da raiva, entre eles, 10 foram conside rados positivos, sendo oito da espécie bovina e dois da espécie eqüina. Com relação ao conhecimento de produto res/empregados rurais sobre a raiva, constatou-se que 74,3% consideram o veterinário como uma importante fonte de informação; 85% procuram o veterinário se houver um animal doente; 97,5% conhecem a importância da vacinação; 72,5% indicaram a salivação aumentada do animal como sintoma característico da doença; 58,3% indicaram o carbúnculo como doença que se confunde com a raiva; 90,0% afirmaram ser o morcego hematófago o transmissor da doença; 57,1% afirma ram aplicar algum tipo de produto em mordeduras por morcegos; 92,5% afirmaram ter conhecimento da presen ça do morcego em sua propriedade; 17,5% afirmaram ter tido caso confirmado de raiva na propriedade; 53% apontaram galpões de secador de café como abrigo para os morcegos; 90% afirmaram vacinar o rebanho durante as campanhas de vacinação. Com relação aos dados da Vigilância Epidemiológica, entre os anos de 2000 e 2006, ocorreram 587 casos de agressão por animais no município de Guaxupé. Desses casos, 24,3% ocorreram com crianças de até nove anos de idade; 91,5% ocorreram na zona urbana; 82,9% dos ferimentos foram por mordedura; 49,0% foram nas mãos; em 78,2% dos casos a espécie agressora era a canina; ocorreu apenas um caso de raiva canina com diagnós tico laboratorial e quatro casos de raiva animal com diagnóstico clínico. Esses estudos permitiram concluir que ainda é atual a necessidade de manter todas as ações que visam o controle da raiva, especialmente a vacinação; é importante a realização de um trabalho de consci entização com relação aos casos de agressão por animais, especialmente os cães.
Bovine rabies continues to be an important zoonosis. The occurrence of confirmed cases of the…
Advisors/Committee Members: Fabbro, Amaury Lelis Dal.
Subjects/Keywords: bovine rabies; epidemiologia; epidemiology; Rabies; raiva; raiva bovina; zoonose; zoonosis
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APA (6th Edition):
Dallora, A. M. B. (2007). Estudo da ocorrência de casos confirmados de raiva bovina no município de Guaxupé, Minas Gerais. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/17/17139/tde-17032008-140516/ ;
Chicago Manual of Style (16th Edition):
Dallora, Andrea Magalhães Barbosa. “Estudo da ocorrência de casos confirmados de raiva bovina no município de Guaxupé, Minas Gerais.” 2007. Masters Thesis, University of São Paulo. Accessed February 28, 2021.
http://www.teses.usp.br/teses/disponiveis/17/17139/tde-17032008-140516/ ;.
MLA Handbook (7th Edition):
Dallora, Andrea Magalhães Barbosa. “Estudo da ocorrência de casos confirmados de raiva bovina no município de Guaxupé, Minas Gerais.” 2007. Web. 28 Feb 2021.
Vancouver:
Dallora AMB. Estudo da ocorrência de casos confirmados de raiva bovina no município de Guaxupé, Minas Gerais. [Internet] [Masters thesis]. University of São Paulo; 2007. [cited 2021 Feb 28].
Available from: http://www.teses.usp.br/teses/disponiveis/17/17139/tde-17032008-140516/ ;.
Council of Science Editors:
Dallora AMB. Estudo da ocorrência de casos confirmados de raiva bovina no município de Guaxupé, Minas Gerais. [Masters Thesis]. University of São Paulo; 2007. Available from: http://www.teses.usp.br/teses/disponiveis/17/17139/tde-17032008-140516/ ;
University of Georgia
21.
Zhang, Xiwen.
Evaluation of long-term protective efficacy of rabies vaccines in dogs.
Degree: 2017, University of Georgia
URL: http://hdl.handle.net/10724/36583
► Rabies is a fatal encephalitis caused by rabies virus. It causes more than 59,000 human deaths worldwide annually. Rabies vaccination can prevent the development of…
(more)
▼ Rabies is a fatal encephalitis caused by rabies virus. It causes more than 59,000 human deaths worldwide annually. Rabies vaccination can prevent the development of rabies in humans and animals. In dogs, booster vaccination is administered
annually or triennially, as per local law or the vaccines used. To evaluate the long-term efficacy of current rabies vaccines, beagles vaccinated 6 and 8 years ago, were challenged with a virulent rabies virus. Blood and lymph node aspirates were
collected for the analysis of immune responses. It was found that 80% of the six-year vaccinated dogs survived with the induction of high levels of virus-neutralizing antibodies (VNA), whereas 80% of the eight-year vaccinated dogs and all of the
non-vaccinated dogs succumbed to rabies. Also, six-year vaccinated dogs induced better cellular immune responses than other dogs. These results indicate that a single shot of rabies vaccine can protect dogs for up to six years.
Subjects/Keywords: Rabies; rabies vaccines; duration of immunity; immune response; virus-neutralizing antibodies
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APA (6th Edition):
Zhang, X. (2017). Evaluation of long-term protective efficacy of rabies vaccines in dogs. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/36583
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Zhang, Xiwen. “Evaluation of long-term protective efficacy of rabies vaccines in dogs.” 2017. Thesis, University of Georgia. Accessed February 28, 2021.
http://hdl.handle.net/10724/36583.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Zhang, Xiwen. “Evaluation of long-term protective efficacy of rabies vaccines in dogs.” 2017. Web. 28 Feb 2021.
Vancouver:
Zhang X. Evaluation of long-term protective efficacy of rabies vaccines in dogs. [Internet] [Thesis]. University of Georgia; 2017. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/10724/36583.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Zhang X. Evaluation of long-term protective efficacy of rabies vaccines in dogs. [Thesis]. University of Georgia; 2017. Available from: http://hdl.handle.net/10724/36583
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Kansas State University
22.
Gonzales, Amado S., Jr.
Infectivity and distribution of skunk rabies virus in mice following oral and parenteral administration.
Degree: 1980, Kansas State University
URL: http://hdl.handle.net/2097/11791
Subjects/Keywords: Rabies; Rabies – Animal models
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APA ·
Chicago ·
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Export
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APA (6th Edition):
Gonzales, Amado S., J. (1980). Infectivity and distribution of skunk rabies virus in mice following oral and parenteral administration. (Thesis). Kansas State University. Retrieved from http://hdl.handle.net/2097/11791
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Gonzales, Amado S., Jr. “Infectivity and distribution of skunk rabies virus in mice following oral and parenteral administration.” 1980. Thesis, Kansas State University. Accessed February 28, 2021.
http://hdl.handle.net/2097/11791.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Gonzales, Amado S., Jr. “Infectivity and distribution of skunk rabies virus in mice following oral and parenteral administration.” 1980. Web. 28 Feb 2021.
Vancouver:
Gonzales, Amado S. J. Infectivity and distribution of skunk rabies virus in mice following oral and parenteral administration. [Internet] [Thesis]. Kansas State University; 1980. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/2097/11791.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Gonzales, Amado S. J. Infectivity and distribution of skunk rabies virus in mice following oral and parenteral administration. [Thesis]. Kansas State University; 1980. Available from: http://hdl.handle.net/2097/11791
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Georgia
23.
Chennareddy, Chakravarthy.
Evaluation of prophylactic efficacy of human anti-rabies monoclonal antibodies in a mouse model.
Degree: 2014, University of Georgia
URL: http://hdl.handle.net/10724/22884
► Rabies post exposure prophylaxis (PEP) includes administration of both vaccine and anti-rabies immunoglobulin. Rabies immunoglobulins are expensive and available in limited quantities. There is an…
(more)
▼ Rabies post exposure prophylaxis (PEP) includes administration of both vaccine and anti-rabies immunoglobulin. Rabies immunoglobulins are expensive and available in limited quantities. There is an inherent variability in quality and
specificity between batches of immunoglobulin preparations and possibility of contamination with known or unknown pathogens. To provide a cost-effective and safe replacement for currently used human rabies immunoglobulin (HRIG) human anti-rabies
monoclonal antibodies (huMAbs) were developed. The present study evaluated the overall prophylactic efficacy of SO57 and SOJB MAbs individually, in a mouse model when used in combination with rabies vaccine and compared with conventional HRIG. When the
protective effect of antibodies was examined in mice challenged with CVS-N2C virus, a dose-dependent survivorship response was observed in animals treated with antibodies and no animal survived in the control group. At the highest dose of antibody given
80% survivorship was recorded for SO57 and SOJB antibodies where as only 50% survived with HRIG. Serum half-lives were found to be approximately 16 days for SO57 (IgG1); 11 days for SOJB (IgG3) and 8 days for HRIG (polyclonal). Furthermore, we
investigated the potential interference of antibodies on vaccine mediated-immunity. When compared to the control group which was given only vaccine shots, the groups of animals given both antibody and vaccine developed lower virus neutralizing antibody
(VNA) titers. The VNA titers appear to be a function of dose of antibody given and serum half-life of each antibody. The interference, as correlated with VNA titers developed in mice, is comparable to HRIG for both SO57 and SOJB MAbs. When we
investigated more on the induction of interference by antibodies on vaccine –mediated immunity with combinations of (i) antibody and different concentrations of vaccine (ii) administration of antibody and vaccine at different time intervals followed by
intracerebral (i.c.) challenge all the groups of mice recorded higher survival rates. But the survival rates for SO57 and SOJB were comparable to that of HRIG. Unlike in the previous studies of mouse monoclonal antibodies, we observed that passively
administered human monoclonal antibodies and HRIG protects mice against intra cerebral challenge. The protective effect at the point of i.c. challenge may be a synergistic effect of passive and active immunities and account for higher survival among
groups. Together this data suggests that human anti-rabies monoclonal antibodies (huMAbs) viz: SO57 and SOJB have potential to replace the currently used human rabies immunoglobulin (HRIG) for rabies post exposure prophylaxis (PEP) regimen. Key words:
Rabies, Post Exposure Prophylaxis (PEP), Human anti-rabies monoclonal antibodies, Therapy.
Subjects/Keywords: Rabies; Post Exposure Prophylaxis (PEP); Human anti-rabies monoclonal antibodies; Therapy.
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Chennareddy, C. (2014). Evaluation of prophylactic efficacy of human anti-rabies monoclonal antibodies in a mouse model. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/22884
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Chennareddy, Chakravarthy. “Evaluation of prophylactic efficacy of human anti-rabies monoclonal antibodies in a mouse model.” 2014. Thesis, University of Georgia. Accessed February 28, 2021.
http://hdl.handle.net/10724/22884.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Chennareddy, Chakravarthy. “Evaluation of prophylactic efficacy of human anti-rabies monoclonal antibodies in a mouse model.” 2014. Web. 28 Feb 2021.
Vancouver:
Chennareddy C. Evaluation of prophylactic efficacy of human anti-rabies monoclonal antibodies in a mouse model. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/10724/22884.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Chennareddy C. Evaluation of prophylactic efficacy of human anti-rabies monoclonal antibodies in a mouse model. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/22884
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Georgia
24.
Tien, Yung-Tien.
Recovery of rabid dogs by intrathecal injection of rabies virus neutralizing antibodies.
Degree: 2018, University of Georgia
URL: http://hdl.handle.net/10724/37195
► Rabies is a fatal neurotropic zoonotic disease. Although rabies is preventable, there is no cure once the virus invades in to the CNS. In this…
(more)
▼ Rabies is a fatal neurotropic zoonotic disease. Although rabies is preventable, there is no cure once the virus invades in to the CNS. In this study, dogs were infected with rabies virus DRV-NYC stain and treated with intrathecal injection
of canine Ig with or without rabies VNA after onset of clinical signs. Dogs without treatment or treated with canine Ig without VNA all died of rabies while 66% of dogs treated with canine Ig with VNA survived. Both rabies N gene and antigen were
detected in the dead, but not in the survived dogs. The inflammation and neuronal damage is extensive in the dead, but minimal in the survived dogs. These results indicate that the intrathecal injection of rabies VNA can clear the virus from the CNS and
save dogs from clinical rabies. The intrathecal treatment with VNA may be a good method to treat clinical rabies in the future.
Subjects/Keywords: Rabies; Rabies Therapy; Immune Therapy; Virus Neutralizing Antibody
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Record Details
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Tien, Y. (2018). Recovery of rabid dogs by intrathecal injection of rabies virus neutralizing antibodies. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/37195
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Tien, Yung-Tien. “Recovery of rabid dogs by intrathecal injection of rabies virus neutralizing antibodies.” 2018. Thesis, University of Georgia. Accessed February 28, 2021.
http://hdl.handle.net/10724/37195.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Tien, Yung-Tien. “Recovery of rabid dogs by intrathecal injection of rabies virus neutralizing antibodies.” 2018. Web. 28 Feb 2021.
Vancouver:
Tien Y. Recovery of rabid dogs by intrathecal injection of rabies virus neutralizing antibodies. [Internet] [Thesis]. University of Georgia; 2018. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/10724/37195.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Tien Y. Recovery of rabid dogs by intrathecal injection of rabies virus neutralizing antibodies. [Thesis]. University of Georgia; 2018. Available from: http://hdl.handle.net/10724/37195
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Massey University
25.
Panichabhongse, Pranee.
The epidemiology of rabies in Thailand : a thesis presented in partial fulfilment of the requirement for the degree of Master of Veterinary Studies
.
Degree: 2001, Massey University
URL: http://hdl.handle.net/10179/4545
► This study was designed to investigate the epidemiology of rabies in Thailand and to evaluate the rabies control programme. The study involved retrospective analysis of…
(more)
▼ This study was designed to investigate the epidemiology of rabies in Thailand and to
evaluate the rabies control programme. The study involved retrospective analysis of
seven years data (1993 to 1999), concerning rabies incidence and control activity. Five
datasets from four different organisations responsible for rabies control in Thailand
were collected between March and June, 2000.
Control activity data were found to be incomplete due mainly to problems associated
with the data collection form and with methods of data storage and retrieval in
provincial offices. Recommendations are made in this thesis to modify the data
collection form and data storage methods to improve data collection and the usefulness
of information collected in the future.
The annual cumulative incidence of rabies in both animals and humans has declined
considerably between 1993 to 1999 as a result of the control programme implemented
under the Rabies Act B.E. 2535 (1992). Rabies in humans is more common in males
than females and is more common in young children (less than 10 years of age) than
any other age group. Dogs were the most commonly submitted animal for rabies
diagnosis as part of the surveillance programme, accounting for 87% of the total of
40,649 submissions. Cows were more likely to return a positive rabies diagnosis than
any other animal (57% of a total of 409 animals submitted) while dogs returned more
cases than any other animal species (43% of a total of 35,338 animals submitted).
Detailed investigations were confined to dogs. Rabies was more common in non-owned
dogs, non-vaccinated dogs, dogs showing signs consistent with furious rabies, and dogs
with a history of having attacked or bitten either other animals or both animals and
people.
The spatio-temporal pattern of rabies in both dogs and people, showed changes in the
distribution of rabies cases during the seven year period of the study. Mixed effect
Poisson regression models incorporating spatial and non-spatial random effect terms
were used to investigate risk factors associated with rabies. Factors associated with
increasing risk of rabies in people at the province level included: increasing dog
density, increasing incidence of rabies in dogs, and reduction in human population
density. In the 1999 dataset, there was evidence of spatial clustering of rabies risk. In
addition a cluster of provinces showed an elevation in rabies risk that was unexplained
by the explanatory variables included in the model. The reason for this cluster of
elevated risk remains to be elucidated.
Factors associated with an increasing risk of rabies in dogs at the province level
included increasing dog population density and increasing proportion of dogs
vaccinated against rabies. Relative risk estimates were close to one suggesting the
strength of the association for both terms was weak. Increased dog vaccination against
rabies is likely to occur in provinces with a higher risk of both animal and human
rabies.
Subjects/Keywords: Rabies;
Rabies in Thailand
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Panichabhongse, P. (2001). The epidemiology of rabies in Thailand : a thesis presented in partial fulfilment of the requirement for the degree of Master of Veterinary Studies
. (Thesis). Massey University. Retrieved from http://hdl.handle.net/10179/4545
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Panichabhongse, Pranee. “The epidemiology of rabies in Thailand : a thesis presented in partial fulfilment of the requirement for the degree of Master of Veterinary Studies
.” 2001. Thesis, Massey University. Accessed February 28, 2021.
http://hdl.handle.net/10179/4545.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Panichabhongse, Pranee. “The epidemiology of rabies in Thailand : a thesis presented in partial fulfilment of the requirement for the degree of Master of Veterinary Studies
.” 2001. Web. 28 Feb 2021.
Vancouver:
Panichabhongse P. The epidemiology of rabies in Thailand : a thesis presented in partial fulfilment of the requirement for the degree of Master of Veterinary Studies
. [Internet] [Thesis]. Massey University; 2001. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/10179/4545.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Panichabhongse P. The epidemiology of rabies in Thailand : a thesis presented in partial fulfilment of the requirement for the degree of Master of Veterinary Studies
. [Thesis]. Massey University; 2001. Available from: http://hdl.handle.net/10179/4545
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Georgia
26.
Tien, Yung-Tien.
Recovery of rabid dogs by intrathecal injection of rabies virus neutralizing antibodies.
Degree: 2018, University of Georgia
URL: http://hdl.handle.net/10724/37038
► Rabies is a fatal neurotropic zoonotic disease. Although rabies is preventable, there is no cure once the virus invades in to the CNS. In this…
(more)
▼ Rabies is a fatal neurotropic zoonotic disease. Although rabies is preventable, there is no cure once the virus invades in to the CNS. In this study, dogs were infected with rabies virus DRV-NYC stain and treated with intrathecal injection
of canine Ig with or without rabies VNA after onset of clinical signs. Dogs without treatment or treated with canine Ig without VNA all died of rabies while 66% of dogs treated with canine Ig with VNA survived. Both rabies N gene and antigen were
detected in the dead, but not in the survived dogs. The inflammation and neuronal damage is extensive in the dead, but minimal in the survived dogs. These results indicate that the intrathecal injection of rabies VNA can clear the virus from the CNS and
save dogs from clinical rabies. The intrathecal treatment with VNA may be a good method to treat clinical rabies in the future.
Subjects/Keywords: Rabies; Rabies Therapy; Immune Therapy; Virus Neutralizing Antibody
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Record Details
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Tien, Y. (2018). Recovery of rabid dogs by intrathecal injection of rabies virus neutralizing antibodies. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/37038
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Tien, Yung-Tien. “Recovery of rabid dogs by intrathecal injection of rabies virus neutralizing antibodies.” 2018. Thesis, University of Georgia. Accessed February 28, 2021.
http://hdl.handle.net/10724/37038.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Tien, Yung-Tien. “Recovery of rabid dogs by intrathecal injection of rabies virus neutralizing antibodies.” 2018. Web. 28 Feb 2021.
Vancouver:
Tien Y. Recovery of rabid dogs by intrathecal injection of rabies virus neutralizing antibodies. [Internet] [Thesis]. University of Georgia; 2018. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/10724/37038.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Tien Y. Recovery of rabid dogs by intrathecal injection of rabies virus neutralizing antibodies. [Thesis]. University of Georgia; 2018. Available from: http://hdl.handle.net/10724/37038
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
27.
Mota, Carla da Silva.
Estudos biológico, imunológico e genético de amostras do vírus da raiva isoladas de morcegos no Estado do Rio de Janeiro - Sudeste, Brasil.
Degree: PhD, Epidemiologia Experimental Aplicada às Zoonoses, 2008, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/10/10134/tde-30052008-143020/
;
► O presente trabalho visou estudar o comportamento biológico em camundongos de 10 amostras de vírus da raiva isoladas de morcegos hematófagos e não-hematófagos, no Estado…
(more)
▼ O presente trabalho visou estudar o comportamento biológico em camundongos de 10 amostras de vírus da raiva isoladas de morcegos hematófagos e não-hematófagos, no Estado do Rio de Janeiro, sua caracterização genética quanto aos genes N e G, além da resposta de camundongos vacinados com a vacina anti-rábica produzida pela replicação da amostra Pitman-Moore em cultivo celular, frente ao desafio com estas amostras virais. As passagens sucessivas em camundongos determinaram uma redução do período de incubação e a obtenção de amostras virais com altos títulos. A vacina anti-rábica utilizada na imunização dos camundongos ofereceu proteção em mais de 80% dos camundongos vacinados com a diluição 1:5 da vacina, frente à maioria das amostras. A análise filogenética do gene da proteína N apresentou um padrão de agregação dividido em variante de morcego hematófago e variante de morcego insetívoro, com diferenças filogenéticas entre as variantes de morcego hematófago isoladas na Região Noroeste do Estado do Rio de Janeiro e aquelas isoladas nas Regiões Metropolitana e Sul do Estado. A substituição do resíduo ácido aspártico por ácido glutâmico na posição 118, encontradas na caracterização genética da proteína G das amostras 704/97 e 151/98, permite inferir que esta posição esteja relacionada à antigenicidade viral. Não foram observadas diferenças genéticas temporais entre as amostras estudadas.
In the present study we analyzed the biological behavior in mice of 10 rabies virus samples isolated from haematophagous and non-haematophagous bats in Rio de Janeiro State, its genetic characterization from genes N and G, and we also studied the response of mice vaccinated with cell culture rabies vaccine, produced with the Pitman-Moore strain, after viral challenge with bat rabies virus samples. Viral passages in mice resulted in reduced incubation period and high virus titrers. The vaccine used conferred protection in more than 80% of the mice vaccinated with 1:15 vaccine dilution, after viral challenge. N gene genetic analysis divided the samples in haematophagous bat strains and insectivorous bat strains, with phylogenetic differences between samples isolated in Northeast Region and those isolated in the Metropolitan and South Regions of Rio de Janeiro State. The substitution of an aspartic acid to a glutamic acid found in the position 118 of G gene genetic characterization from samples 704/97 and 151/98 seems to be related to viral antigenicity. There were no time-related genetic differences between the studied samples.
Advisors/Committee Members: Ito, Fumio Honma.
Subjects/Keywords: Bats; Filogenia; Morcegos; Phylogeny; Rabies; Rabies vaccine; Rabies virus; Raiva; Vacina anti-rábica; Vírus da raiva
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APA ·
Chicago ·
MLA ·
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APA (6th Edition):
Mota, C. d. S. (2008). Estudos biológico, imunológico e genético de amostras do vírus da raiva isoladas de morcegos no Estado do Rio de Janeiro - Sudeste, Brasil. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/10/10134/tde-30052008-143020/ ;
Chicago Manual of Style (16th Edition):
Mota, Carla da Silva. “Estudos biológico, imunológico e genético de amostras do vírus da raiva isoladas de morcegos no Estado do Rio de Janeiro - Sudeste, Brasil.” 2008. Doctoral Dissertation, University of São Paulo. Accessed February 28, 2021.
http://www.teses.usp.br/teses/disponiveis/10/10134/tde-30052008-143020/ ;.
MLA Handbook (7th Edition):
Mota, Carla da Silva. “Estudos biológico, imunológico e genético de amostras do vírus da raiva isoladas de morcegos no Estado do Rio de Janeiro - Sudeste, Brasil.” 2008. Web. 28 Feb 2021.
Vancouver:
Mota CdS. Estudos biológico, imunológico e genético de amostras do vírus da raiva isoladas de morcegos no Estado do Rio de Janeiro - Sudeste, Brasil. [Internet] [Doctoral dissertation]. University of São Paulo; 2008. [cited 2021 Feb 28].
Available from: http://www.teses.usp.br/teses/disponiveis/10/10134/tde-30052008-143020/ ;.
Council of Science Editors:
Mota CdS. Estudos biológico, imunológico e genético de amostras do vírus da raiva isoladas de morcegos no Estado do Rio de Janeiro - Sudeste, Brasil. [Doctoral Dissertation]. University of São Paulo; 2008. Available from: http://www.teses.usp.br/teses/disponiveis/10/10134/tde-30052008-143020/ ;
University of Cambridge
28.
Ciabatti, Ernesto.
Life-long genetic and functional access to neural circuits.
Degree: PhD, 2018, University of Cambridge
URL: https://doi.org/10.17863/CAM.22897
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744822
► Network dynamics are thought to be the substrate of brain information processing and of mental representations. Moreover, network-wide dysfunctions are recognized to be at the…
(more)
▼ Network dynamics are thought to be the substrate of brain information processing and of mental representations. Moreover, network-wide dysfunctions are recognized to be at the core of several psychiatric and neurodegenerative disorders. Yet, our ability to target specific networks for functional or genetic manipulations remains limited. The development of monosynaptically-restricted Rabies virus, G-deleted Rabies virus (ΔG-Rabies), has greatly facilitated the anatomical investigation of neural circuits, revealing the network synaptic structure upstream of defined neuronal populations. However, the inherent cytotoxicity of the Rabies virus largely restrains its use to the mere structural characterisation of neural networks. To overcome this limitation, I generated novel tools that allow the manipulation of neural networks for the entire life of the animal, without affecting neuronal and circuit properties. I first developed a viral system obtained by engineering the Rabies virus genome to eliminate its cytotoxicity. This led to the generation of a Self-inactivating Rabies virus (SiR) that transcriptionally disappears from the infected neurons while leaving permanent genetic access to the traced network. I showed that SiR provides a virtually unlimited temporal window for the functional manipulation of neural circuits in vivo without adverse effects on neuronal physiology. To further expand our ways of intervening on neural networks function I then developed a completely virus-free system, named Genetically-Encoded TransSynaptic Shuttle (GETSS), which is the only specific genetically-encoded transsynaptic tracer to date. In this thesis, I established novel approaches that provide, for the first time, the functional and genetic access to traced network elements in vivo for the lifetime of the animal, with no cytotoxic effects, no changes in the electrophysiological properties of the traced neurons and no adverse effects on network function. This opens new horizons in the functional investigation of neural circuits and potentially represent the first approaches to experimentally monitor neural circuit remodelling in vivo.
Subjects/Keywords: 573.8; Rabies; transsynaptic; retrograde; neural tracing; neural network; neural circuits; SiR virus; Self-inactivating Rabies; DG-Rabies; network manipulation
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APA (6th Edition):
Ciabatti, E. (2018). Life-long genetic and functional access to neural circuits. (Doctoral Dissertation). University of Cambridge. Retrieved from https://doi.org/10.17863/CAM.22897 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744822
Chicago Manual of Style (16th Edition):
Ciabatti, Ernesto. “Life-long genetic and functional access to neural circuits.” 2018. Doctoral Dissertation, University of Cambridge. Accessed February 28, 2021.
https://doi.org/10.17863/CAM.22897 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744822.
MLA Handbook (7th Edition):
Ciabatti, Ernesto. “Life-long genetic and functional access to neural circuits.” 2018. Web. 28 Feb 2021.
Vancouver:
Ciabatti E. Life-long genetic and functional access to neural circuits. [Internet] [Doctoral dissertation]. University of Cambridge; 2018. [cited 2021 Feb 28].
Available from: https://doi.org/10.17863/CAM.22897 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744822.
Council of Science Editors:
Ciabatti E. Life-long genetic and functional access to neural circuits. [Doctoral Dissertation]. University of Cambridge; 2018. Available from: https://doi.org/10.17863/CAM.22897 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744822
University of Pretoria
29.
[No author].
Molecular epidemiology of dog rabies in Nigeria :
phylogeny based on N and G gene sequences
.
Degree: 2010, University of Pretoria
URL: http://upetd.up.ac.za/thesis/available/etd-02172010-160705/
► The domestic dog is the principal reservoir of rabies in Nigeria and the source of infection for over 99% of human cases that have been…
(more)
▼ The domestic dog is the principal reservoir of
rabies in Nigeria and the source of infection for over 99% of human
cases that have been documented. The first recorded cases of human
and dog
rabies were in 1912 and 1928 respectively. The disease has
been continually diagnosed in the domestic dog until to date. One
of the control measures practiced in this West African country
includes the vaccination of domestic dogs with readily available
rabies vaccines. However, trend analyses show that dog
rabies is
increasing probably indicating that the vaccination programmes are
inadequate.
Rabies is a member of the Lyssavirus genus and
currently comprises of seven genotypes (GT 1-7) namely the
classical
rabies virus (RABV) GT1, Lagos bat virus (LBV) GT2,
Mokola virus (MOKV) GT3, Duvenhage (DUVV) GT4, European bat
lyssavirus type-1 (EBLV-1) GT5, European bat lyssavirus type-2
(EBLV-2) GT6 and Australian bat lyssavirus (ABL) GT7. Three of
these have been identified in Nigeria (classical
rabies (RABV) (GT
1), Lagos bat virus (LBV) (GT 2) and Mokola virus (MOKV) (GT 3).
The domestic dog is the major maintenance and vector species of
rabies in this country and the West Africa sub-region. This study
was therefore undertaken to further elucidate the epidemiology of
dog
rabies in Nigeria. Secondly, it was the aim of this study to
determine the phylogenetic relationships of dog
rabies viruses and
the distribution of the respective
rabies variants. Finally, to
assess the phylogenetic relationships of the viruses in the study
sample with those of the neighbouring countries (Chad, Cameroon,
Benin and Niger). A panel of 100 viruses recovered primarily from
the domestic dog was included in the study. Partial regions of the
nucleoprotein gene (n=100) and the cytoplasmic domain of the
glycoprotein and the G-L intergenic region (n=80) were successfully
amplified, sequenced and phylogenetically analysed. Nucleotide
sequences of representative
rabies viruses of the partial N gene of
the neighbouring countries and elsewhere in Africa available in the
GenBank were also included in the phylogenetic analysis. The
phylogenetic analysis demonstrated that the
rabies viruses from the
study sample were closely related with a 99% sequence homology for
both the N and G regions but despite the close homogeneity the
viruses segregated into two major clusters. Within the major
cluster 1, three sub-clades were identified comprising of
rabies
isolates from the northern part of Nigeria whereas cluster 2 was
made of viruses from the southern part of the country together with
an isolate from a stray dog. Further analysis of representative
viruses from the study sample with viruses from the GenBank
revealed an evolutionary link with the viruses from Chad, Benin,
Cameroon and Niger with a ≥96% sequence homology. The demonstration
of the evolutionary link of
rabies viruses in the study sample and
those from neighbouring countries indicates the transboundary
nature of
rabies and the existence of an active
rabies cycle in the
region. The study data revealed that a…
Advisors/Committee Members: Dr C T Sabeta (advisor).
Subjects/Keywords: Glycoprotein;
Rabies;
Molecular epidemiology;
Nigeria;
Nucleoprotein;
UCTD
Record Details
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
author], [. (2010). Molecular epidemiology of dog rabies in Nigeria :
phylogeny based on N and G gene sequences
. (Masters Thesis). University of Pretoria. Retrieved from http://upetd.up.ac.za/thesis/available/etd-02172010-160705/
Chicago Manual of Style (16th Edition):
author], [No. “Molecular epidemiology of dog rabies in Nigeria :
phylogeny based on N and G gene sequences
.” 2010. Masters Thesis, University of Pretoria. Accessed February 28, 2021.
http://upetd.up.ac.za/thesis/available/etd-02172010-160705/.
MLA Handbook (7th Edition):
author], [No. “Molecular epidemiology of dog rabies in Nigeria :
phylogeny based on N and G gene sequences
.” 2010. Web. 28 Feb 2021.
Vancouver:
author] [. Molecular epidemiology of dog rabies in Nigeria :
phylogeny based on N and G gene sequences
. [Internet] [Masters thesis]. University of Pretoria; 2010. [cited 2021 Feb 28].
Available from: http://upetd.up.ac.za/thesis/available/etd-02172010-160705/.
Council of Science Editors:
author] [. Molecular epidemiology of dog rabies in Nigeria :
phylogeny based on N and G gene sequences
. [Masters Thesis]. University of Pretoria; 2010. Available from: http://upetd.up.ac.za/thesis/available/etd-02172010-160705/
University of Pretoria
30.
[No author].
Molecular epidemiology of human rabies diagnosed in
South Africa between 1983 and 2007
.
Degree: 2010, University of Pretoria
URL: http://upetd.up.ac.za/thesis/available/etd-10012009-113551/
► Human rabies is a zoonotic viral disease that affects thousands of people worldwide, especially in the developing countries of Africa and Asia. There are two…
(more)
▼ Human
rabies is a zoonotic viral disease that
affects thousands of people worldwide, especially in the developing
countries of Africa and Asia. There are two distinct biotypes of
lyssavirus genotype 1 circulating in South Africa: a canine biotype
circulating in domestic dogs, bat-eared foxes and black-backed
jackals and a mongoose biotype circulating in herpestids. The
presence of LBV, MOKV and DUVV has been demonstrated in South
African animal species, but apart from two documented cases of
Duvenhage infection in humans, no other lyssaviruses other than
genotype 1 have been reported to clinically manifest in humans.
Since canine
rabies is endemic to the KwaZulu Natal province where
the majority of human
rabies cases occur, dog vaccination campaigns
have been implemented to control and prevent
rabies in the region.
The first outbreak of canine
rabies in the province from the 1950s
to 1968 was successfully controlled, but after its re-emergence in
the 1970s dog vaccination campaigns have been unsuccessful for a
variety of reasons, including lack of commitment for implementation
of effective control measures and the difficulty of accessing
certain areas in the province. In addition to these problems, human
rabies emerged in the Limpopo province during 2005/2006. This
emergence was potentially due to the introduction of canine
rabies
from either black-backed jackals or dogs in Zimbabwe, as there was
a large increase of canine
rabies cases in the province before the
human outbreak. Some dog vaccination campaigns and stray dog
population control measures were established in the province, but
there are still human
rabies cases being reported from the region
annually. In order to gain a clearer understanding of human
rabies
in the country, this study was undertaken to elucidate various
epidemiological aspects of human
rabies in the country, to
correlate the existing knowledge of animal
rabies cycles to human
rabies cycles and also to determine whether or not lyssaviruses
other than genotype 1 have been involved in causing human
rabies in
South Africa. The study confirmed that the domestic dog is the
primary vector for human
rabies in South Africa, with most cases
occurring in the KwaZulu Natal province. Men and young adults under
the age of 21 were most affected. Only very small portion of
affected people sought and received post-exposure prophylaxis. This
was either due to a lack of vaccine and immunoglobulin or a lack of
knowledge of the risk of the disease after an animal exposure. The
findings from the molecular epidemiology study reinforced the
previous findings which correlate most human
rabies cases with the
coastal KwaZulu Natal canine cluster identified in previous
studies. As humans are a dead end host to
rabies infection, it was
expected that the molecular epidemiology of the human
rabies
isolates would mimic the molecular epidemiology of the existing
animal cycles and this proved to be the case. The human
rabies
virus isolates all grouped closely to their representative animal
cycles, which grouped by respective…
Advisors/Committee Members: Prof L H Nel (advisor), Dr W Markotter (advisor), Dr J Weyer (advisor), Dr J T Paweska (advisor).
Subjects/Keywords: Molecular epidemiology;
Human rabies;
South africa;
UCTD
Record Details
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Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
author], [. (2010). Molecular epidemiology of human rabies diagnosed in
South Africa between 1983 and 2007
. (Masters Thesis). University of Pretoria. Retrieved from http://upetd.up.ac.za/thesis/available/etd-10012009-113551/
Chicago Manual of Style (16th Edition):
author], [No. “Molecular epidemiology of human rabies diagnosed in
South Africa between 1983 and 2007
.” 2010. Masters Thesis, University of Pretoria. Accessed February 28, 2021.
http://upetd.up.ac.za/thesis/available/etd-10012009-113551/.
MLA Handbook (7th Edition):
author], [No. “Molecular epidemiology of human rabies diagnosed in
South Africa between 1983 and 2007
.” 2010. Web. 28 Feb 2021.
Vancouver:
author] [. Molecular epidemiology of human rabies diagnosed in
South Africa between 1983 and 2007
. [Internet] [Masters thesis]. University of Pretoria; 2010. [cited 2021 Feb 28].
Available from: http://upetd.up.ac.za/thesis/available/etd-10012009-113551/.
Council of Science Editors:
author] [. Molecular epidemiology of human rabies diagnosed in
South Africa between 1983 and 2007
. [Masters Thesis]. University of Pretoria; 2010. Available from: http://upetd.up.ac.za/thesis/available/etd-10012009-113551/
◁ [1] [2] [3] [4] [5] [6] [7] [8] ▶
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Open Access Theses and Dissertations
