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Kristianstad University

1. Khashayar, Mahdavisabet. Påverkan på PK(INR)-värdet efter olika preanalytiska behandlingar i venöst humanblod.

Degree: Education and Environment, 2015, Kristianstad University

Venous thromboembolism that cause blood clotting in blood vessels, prevent blood circulation, depending on changes in one or more of the coagulation factors II, VII, IX and X. Patients who have had a blood clot or cardiovascular diseases are treated with oral anti-vitamin K (Warfarin®) to reducing and prevent relapse. Warfarin is also used as a preventive treatment before the disease. An overdose of Warfarin® may cause bleeding-complications and low dose cause blood clotting. The dosage of the drug is controlled by measuring prothrombin in plasma. The aim of this study was to investigate if prothrombin-complex value changes due to re-spinning and re-analysis after six hours. Fitty whole blood samples from warfarin-treated patients were divided into three subgroups, those with protrombinkomplex-values of 2-4 (n=20), >4 (n=15) and <2 (n=15). The samples were centrifugated and measured (Method A), re-centrifugated and measured (Method B) or re-analysed after six hours (Method C). All results were compared in a Bland-Altman plot as follows: Method B vs. Method A and Method C vs. Method A. The scatter graph yielded a strong correlation between Method A and Method B (R2=0.9984) and Method A and Methods C (R2=0.9977). The results from t-test showed a significance level (p<0.001) for both analyses (statistical significance=p<0.05). In this study we showed that prothrombin complex value ware stable after re-centrifugation and re-measurement after six hours. Statistical calculations yielded a strong correlation between the methods (A, B, C), and there was no significance difference between the methods.

Subjects/Keywords: Venous thromboembolism; prothrombin complex; Warfarin®; anti-vitamin K; re-spin; blood clotting; coagulation factors; Venös tromboembolism; protrombinkomplex; antivitamin-K; waran; återcentrifugering; blodproppar; koagulationsfaktorer; Medicinal Chemistry; Läkemedelskemi; Biomedical Laboratory Science/Technology; Biomedicinsk laboratorievetenskap/teknologi

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Khashayar, M. (2015). Påverkan på PK(INR)-värdet efter olika preanalytiska behandlingar i venöst humanblod. (Thesis). Kristianstad University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-15316

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Khashayar, Mahdavisabet. “Påverkan på PK(INR)-värdet efter olika preanalytiska behandlingar i venöst humanblod.” 2015. Thesis, Kristianstad University. Accessed September 22, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-15316.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Khashayar, Mahdavisabet. “Påverkan på PK(INR)-värdet efter olika preanalytiska behandlingar i venöst humanblod.” 2015. Web. 22 Sep 2020.

Vancouver:

Khashayar M. Påverkan på PK(INR)-värdet efter olika preanalytiska behandlingar i venöst humanblod. [Internet] [Thesis]. Kristianstad University; 2015. [cited 2020 Sep 22]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-15316.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Khashayar M. Påverkan på PK(INR)-värdet efter olika preanalytiska behandlingar i venöst humanblod. [Thesis]. Kristianstad University; 2015. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-15316

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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