subject:(pre metastatic niche)

Universiteit Utrecht

1. Kersten, K. Predicting breast cancer metastasis; formation of the pre-metastatic niche.

Degree: 2011, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/198650

► The leading cause of death in breast cancer patients is tumor metastasis. This process includes several steps that all need to be completed successfully to… (more)

Subjects/Keywords: breast cancer; metastasis; pre-metastatic niche; tissue tropism; gene-expression signatures

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APA (6^th Edition):

Kersten, K. (2011). Predicting breast cancer metastasis; formation of the pre-metastatic niche. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/198650

Chicago Manual of Style (16^th Edition):

Kersten, K. “Predicting breast cancer metastasis; formation of the pre-metastatic niche.” 2011. Masters Thesis, Universiteit Utrecht. Accessed March 03, 2021. http://dspace.library.uu.nl:8080/handle/1874/198650.

MLA Handbook (7^th Edition):

Kersten, K. “Predicting breast cancer metastasis; formation of the pre-metastatic niche.” 2011. Web. 03 Mar 2021.

Vancouver:

Kersten K. Predicting breast cancer metastasis; formation of the pre-metastatic niche. [Internet] [Masters thesis]. Universiteit Utrecht; 2011. [cited 2021 Mar 03]. Available from: http://dspace.library.uu.nl:8080/handle/1874/198650.

Council of Science Editors:

Kersten K. Predicting breast cancer metastasis; formation of the pre-metastatic niche. [Masters Thesis]. Universiteit Utrecht; 2011. Available from: http://dspace.library.uu.nl:8080/handle/1874/198650

Penn State University

2. Chin-quee, Karis P. Breast cancer cell secretions promote a pre-metastatic niche in bone; an in vitro look .

Degree: 2013, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/17496

► ABSTRACT Successful metastasis requires some degree of hospitality from the host organ that is metastasized. In recent years, evidence has been mounting that the primary… (more)

▼ ABSTRACT Successful metastasis requires some degree of hospitality from the host organ that is metastasized. In recent years, evidence has been mounting that the primary tumor contributes to adapting this remote organ to increase this hospitality. Interestingly, many in vitro experiments have shown that conditioned media from cancer cells produce physical changes which theoretically could facilitate invasion. These include perturbations in extracellular matrix and of cell to cell adhesions. The conditioned media in these in vitro experiments could be interpreted to be a proxy for either paracrine or endocrine effects, however, when these observations are coupled with evidence from in vivo experiments, it seems possible that primary tumors have remote effects on un-metastasized organs that can elicit changes in them which are pro-metastatic. We have performed a series of experiments designed to characterize and describe changes in osteoblasts (hFOB) which occur as a result of exposure to conditioned medium from breast cancer cells (MDA-MET). Functional experiments aimed at investigating whether these changes are pro-metastatic were included as a means of this characterization. Thus cell to cell adhesions, as well as the ability of the osteoblastic environment to attract MDA-MET cells were both assessed. Further, we investigated mechanistically the bases behind the observations from the functional experiments. Methods Confluent hFOB cells were treated with conditioned media from either MDA-MET, MDA-MB-231 HTERT-HME1 or hFOB cells 24 hrs. This treatment conditioned medium was removed, the cells washed and serum-free medium added to the hFOB cells. hFOB-conditioned medium was collected after 18hrs. This medium was then used in in vitro migration assays measuring number of MDA-MET migratory cells by labeling the cells with DNA-binding dye Cyquant; in establishing presence of collagen by western blot; in collagenase assays and in a cytokine array where antibodies to 74 cytokines were embedded on a membrane. The presence of Type 1 collagen receptors was shown by immunocytochemistry. The data were analyzed using one way ANOVA and the Student’s T test. Results We found that conditioned medium from hFOB cells that had been treated with MDA-MET-conditioned medium attracted more MDA-MET cells than hFOB cells pre-exposed to its own medium only. We hypothesized that Type 1 collagen fragments of specific length were the chemoattractants responsible for our observed effect. This was evidenced by an increase in collagenase in the conditioned medium of hFOB cells which had been exposed to MDA-MET-conditioned medium. The definitiveness of this evidence was aided by the inherent fidelity of the collagenase enzymes and its Type 1 collagen substrate and the distinctiveness of the product of this enzyme substrate interaction. We also showed that bacterial collagenase, which creates short collagen fragments of non-specific length removed the ability of hFOB -conditioned medium to attract MDA-MET cells. In addition, we showed that at… Advisors/Committee Members: Henry Joseph Donahue, Dissertation Advisor/Co-Advisor, Henry Joseph Donahue, Committee Chair/Co-Chair, Andrea Manni, Committee Member, Andrea Marie Mastro, Committee Member, David Feith, Committee Member, Lisa M Shantz, Committee Member, Ralph Lauren Keil, Committee Member.

Subjects/Keywords: breast cancer metastasis; pre-metastatic niche; bone; collagen fragments; collagenase

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APA (6^th Edition):

Chin-quee, K. P. (2013). Breast cancer cell secretions promote a pre-metastatic niche in bone; an in vitro look . (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/17496

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chin-quee, Karis P. “Breast cancer cell secretions promote a pre-metastatic niche in bone; an in vitro look .” 2013. Thesis, Penn State University. Accessed March 03, 2021. https://submit-etda.libraries.psu.edu/catalog/17496.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chin-quee, Karis P. “Breast cancer cell secretions promote a pre-metastatic niche in bone; an in vitro look .” 2013. Web. 03 Mar 2021.

Vancouver:

Chin-quee KP. Breast cancer cell secretions promote a pre-metastatic niche in bone; an in vitro look . [Internet] [Thesis]. Penn State University; 2013. [cited 2021 Mar 03]. Available from: https://submit-etda.libraries.psu.edu/catalog/17496.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chin-quee KP. Breast cancer cell secretions promote a pre-metastatic niche in bone; an in vitro look . [Thesis]. Penn State University; 2013. Available from: https://submit-etda.libraries.psu.edu/catalog/17496

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Melbourne

3. Sceneay, Jaclyn Elise. The role of hypoxic signalling in the primary tumour microenvironment and metastasis in breast cancer.

Degree: 2013, University of Melbourne

URL: http://hdl.handle.net/11343/38389

► Intratumoural hypoxia is a poor prognostic factor associated with reduced disease-free survival in many cancer types, including breast cancer. Under hypoxic conditions, tumour cells signal… (more)

▼ Intratumoural hypoxia is a poor prognostic factor associated with reduced disease-free survival in many cancer types, including breast cancer. Under hypoxic conditions, tumour cells signal via the hypoxic response pathway and stabilisation of the HIF-1 transcription factor to increase the expression of genes that promote survival, proliferation, angiogenesis, invasion and metastatic spread. The factors secreted from hypoxic tumour cells help to recruit various stromal and bone marrow-derived cell (BMDC) lineages that together create a growth-supporting primary tumour microenvironment. The aims of this thesis are twofold; to investigate novel treatments targeting HIF-1 in the primary tumour microenvironment, and to investigate the effects of hypoxic signalling on pre-metastatic niche formation in breast cancer. Antioxidants have been identified as potential anti-cancer drugs that reduce tumour growth and metastasis in a HIF-1-dependent manner. N-acetylcysteine (NAC) is one such antioxidant that has a promising but somewhat controversial role in cancer therapy. This study utilised three orthotopic, syngeneic murine models of breast cancer, the PyMT, EO771 and 4T1.2 models, to investigate the ability of NAC to regulate the hypoxic response in breast tumour cells, and prevent tumour growth and metastasis. NAC demonstrated an ability to prevent HIF-1 stabilisation and signalling via the hypoxic response pathway in breast tumour cells in vitro. When administered in vivo however, NAC treatment did not inhibit primary tumour growth or metastasis. Furthermore, NAC treatment promoted metastases formation in an experimental metastasis model. This work brings into question the validity of NAC as an anti-tumourigenic agent in breast cancer, and highlights the need to further investigate its properties in vivo in different cancer models. Recently, it has been demonstrated that a primary tumour promotes metastasis through the formation of supportive microenvironments, termed pre-metastatic niches, in secondary organs predisposed to metastases. Cytokines, chemokines and growth factors secreted from tumour cells promote the mobilisation and recruitment of BMDCs to pre-metastatic organs, where they interact with the extracellular matrix and other stromal components to create tumour-promoting niches. While hypoxic tumour cells themselves have an increased ability to metastasize, they also secrete a variety of factors independently identified in pre-metastatic niches. This study investigated the combinatorial effect of factors secreted from hypoxic breast tumour cells on pre-metastatic niche formation in distant organs. Using immune competent eGFP bone marrow chimeric mice and different syngeneic mammary cancer models, hypoxic factors were shown to create an immunosuppressed environment in pre-metastatic organs. A subset of granulocytic CD11b+/Ly6Cmed/Ly6G+ myeloid-derived suppressor cells with increased CCR2 expression and STAT3 signalling were…

Subjects/Keywords: hypoxia; breast cancer; tumour microenvironment; pre-metastatic niche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sceneay, J. E. (2013). The role of hypoxic signalling in the primary tumour microenvironment and metastasis in breast cancer. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/38389

Chicago Manual of Style (16^th Edition):

Sceneay, Jaclyn Elise. “The role of hypoxic signalling in the primary tumour microenvironment and metastasis in breast cancer.” 2013. Doctoral Dissertation, University of Melbourne. Accessed March 03, 2021. http://hdl.handle.net/11343/38389.

MLA Handbook (7^th Edition):

Sceneay, Jaclyn Elise. “The role of hypoxic signalling in the primary tumour microenvironment and metastasis in breast cancer.” 2013. Web. 03 Mar 2021.

Vancouver:

Sceneay JE. The role of hypoxic signalling in the primary tumour microenvironment and metastasis in breast cancer. [Internet] [Doctoral dissertation]. University of Melbourne; 2013. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/11343/38389.

Council of Science Editors:

Sceneay JE. The role of hypoxic signalling in the primary tumour microenvironment and metastasis in breast cancer. [Doctoral Dissertation]. University of Melbourne; 2013. Available from: http://hdl.handle.net/11343/38389

University of Michigan

4. Bushnell, Grace. Therapeutic Benefit of Scaffolds That Capture Metastatic Tumor Cells in vivo.

Degree: PhD, Biomedical Engineering, 2019, University of Michigan

URL: http://hdl.handle.net/2027.42/150008

► For most cancers, the formation of distant metastasis is the point at which clinical treatment shifts from curative intent to extending progression free survival. Physicians… (more)

▼ For most cancers, the formation of distant metastasis is the point at which clinical treatment shifts from curative intent to extending progression free survival. Physicians are currently unable to diagnose metastasis until disseminated tumor cells affect the function of a target organ as a secondary tumor. This dissertation describes a novel approach where implantable biomaterial scaffolds are used to recruit metastatic tumor cells for early detection prior to colonization of solid organs. This recruitment of tumor cells to a defined site can not only serve as a platform for detection, but can also have therapeutic effects and be used as a platform to study metastatic processes. This dissertation describes work in each of these three areas including using an implantable biomaterial scaffold for early detection, therapeutic benefit, and a platform to study metastasis. The therapeutic benefit of scaffolds was demonstrated by scaffold implantation significantly enhancing disease-free survival in a murine model of triple negative breast cancer. Myeloid derived suppressor cells were the key population of immune cells whose capture at the scaffold and reduction in the spleen and primary tumor lead to enhanced survival. In an effort to probe the contributions of various immune cell types to the formation and maintenance of the pre-metastatic and metastatic niche in vivo, a gene delivery approach was utilized to alter the immune microenvironment of the scaffold and investigate the recruitment of tumor cells, finding reduced immune and tumor cell recruitment with IL-10 delivery and developing a model of tumor cell recruitment that is dependent upon the proportion of each immune cell type in the niche. Additional efforts to use the scaffold to study metastasis included studying scaffold captured tumor cells relative to tumor cells derived from other locations. Scaffold captured tumor cells were a highly aggressive population of metastatic tumor cells similar to those found in a metastatic lung, underscoring the use of the scaffold as a sampling location for metastatic disease that is reflective of tumor cell phenotype in solid organs. Next, biomaterial scaffolds were also validated in transgenic models of both breast and pancreatic cancer to identify immune dysregulation as a function of tumor burden, recruit tumor cells, and to reduce tumor burden. Finally, non-invasive ultrasound imaging and subsequent spectral analysis techniques were applied to identify changes in the scaffold associated with tumor burden and tumor cell recruitment. Taken together, this body of work supports that the implantable biomaterial scaffold technology provides a robust and novel approach for the early detection of metastatic disease in both breast and pancreatic cancer, therapy to divert both pre-metastatic niche forming immune cells and tumor cells themselves to an ectopic site and away from solid organs, and as a platform to study mechanisms of the pre-metastatic niche and metastasis. Advisors/Committee Members: Shea, Lonnie David (committee member), Jeruss, Jacqueline S (committee member), Shikanov, Ariella (committee member), Wicha, Max S (committee member).

Subjects/Keywords: biomaterials; cancer metastasis; pre-metastatic niche; immunomodulation and immune engineering; diagnostic devices; Biomedical Engineering; Engineering

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bushnell, G. (2019). Therapeutic Benefit of Scaffolds That Capture Metastatic Tumor Cells in vivo. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/150008

Chicago Manual of Style (16^th Edition):

Bushnell, Grace. “Therapeutic Benefit of Scaffolds That Capture Metastatic Tumor Cells in vivo.” 2019. Doctoral Dissertation, University of Michigan. Accessed March 03, 2021. http://hdl.handle.net/2027.42/150008.

MLA Handbook (7^th Edition):

Bushnell, Grace. “Therapeutic Benefit of Scaffolds That Capture Metastatic Tumor Cells in vivo.” 2019. Web. 03 Mar 2021.

Vancouver:

Bushnell G. Therapeutic Benefit of Scaffolds That Capture Metastatic Tumor Cells in vivo. [Internet] [Doctoral dissertation]. University of Michigan; 2019. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/2027.42/150008.

Council of Science Editors:

Bushnell G. Therapeutic Benefit of Scaffolds That Capture Metastatic Tumor Cells in vivo. [Doctoral Dissertation]. University of Michigan; 2019. Available from: http://hdl.handle.net/2027.42/150008

5. Rovera, Christopher. Étude des propriétés contractiles des fibroblastes du ganglion lymphatique au cours de la mise en place de la niche pré-métastatique du mélanome : Study of the contractile properties of fibroblasts of the lymph node during the establishment of the pre-metastatic niche of melanoma.

Degree: Docteur es, Sciences de la vie et de la santé, 2020, Université Côte d'Azur

URL: http://www.theses.fr/2020COAZ6013

► Le mélanome est le cancer de la peau le plus agressif. Il est caractérisé par une progression rapide des métastases, et une forte plasticité des… (more)

▼ Le mélanome est le cancer de la peau le plus agressif. Il est caractérisé par une progression rapide des métastases, et une forte plasticité des cellules tumorales. On distingue des cellules au phénotype prolifératif avec une signature MITFhigh AXLlow et des cellules au profil invasif dé-différencié AXLhigh MITFlow. Ces cellules peuvent transiter d’un phénotype à l’autre en fonction des signaux du microenvironnement. Le mélanome possède un fort tropisme pour le ganglion lymphatique. Il sécrète des vésicules extracellulaires et des facteurs solubles capables de migrer dans le ganglion drainant et de reprogrammer les cellules du ganglion pour créer une niche pré-métastatique favorable à l’implantation tumorale. Dans le ganglion lymphatique, les Cellules Réticulaires Fibroblastiques (FRC) sont des myofibroblastes qui contrôlent l’architecture du ganglion ainsi que sa dilatation lors des réponses immunitaires. Les FRC sécrètent également des chimiokines et des cytokines ainsi qu’un réseau matriciel de conduits qui régulent le recrutement, la survie, l’activation et la circulation des cellules immunitaires. La modification architecturale du ganglion pré-métastatique est une des caractéristiques des cancers lymphophiles, comme le mélanome, mais les liens entre les facteurs sécrétés par le mélanome et les propriétés contractiles des FRC ne sont pas connus.Au cours de ma thèse, j’ai étudié l’effet des facteurs sécrétés par le mélanome sur les propriétés contractiles des FRC. J’ai identifié que les protéines sécrétées par les cellules de mélanome invasives à signature AXLhigh MITFlow, mais pas par les cellules au phénotype prolifératif, inhibent la contractilité du squelette d'actomyosine des FRC en inhibant la voie RHOA et RHO-kinase (ROCK) et le co-activateur transcriptionnel mécanosensible YAP, ce qui conduit à une diminution des fibres de stress et à une modulation de la morphologie des FRC. Ces effets sont indépendants des vésicules extracellulaires sécrétées par les mélanomes invasifs, et sont induits par l'inhibition de JAK1 et du facteur de transcription en aval, STAT3. Mes résultats suggèrent donc que les facteurs sécrétés par les cellules de mélanome invasives pourraient moduler les propriétés biomécaniques du ganglion pré-métastatique. Ils montrent également que la contractilité spontanée de l'actomyosine dans les FRC humains est déterminée par l'activité basale de JAK1-STAT3 en amont des voies de signalisation RHOA-ROCK et YAP. Par ailleurs, j’ai montré que les facteurs sécrétés par les lignées de mélanome invasives induisent également l'activation et la prolifération des FRC, ainsi que la modification du profil de cytokines et chimiokines sécrétées par les FRC.Mes travaux de thèse démontrent que les facteurs sécrétés par les mélanomes invasifs reprogramment profondément les FRC dans le ganglion pré-métastatique. Ils participent à une meilleure compréhension des interactions entre le mélanome et le ganglion lymphatique qui pourrait aboutir à la mise au point de nouveaux biomarqueurs ou de nouvelles cibles… Advisors/Committee Members: Tartare-Deckert, Sophie (thesis director), Prod'homme, Virginie (thesis director).

Subjects/Keywords: Mélanome; Cellules réticulaires fibroblastiques; Ganglion lymphatique; Niche pré-métastatique; Contraction; Melanoma; Fibroblastic reticular cells; Lymph node; Pre-metastatic niche; Contractility

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rovera, C. (2020). Étude des propriétés contractiles des fibroblastes du ganglion lymphatique au cours de la mise en place de la niche pré-métastatique du mélanome : Study of the contractile properties of fibroblasts of the lymph node during the establishment of the pre-metastatic niche of melanoma. (Doctoral Dissertation). Université Côte d'Azur. Retrieved from http://www.theses.fr/2020COAZ6013

Chicago Manual of Style (16^th Edition):

Rovera, Christopher. “Étude des propriétés contractiles des fibroblastes du ganglion lymphatique au cours de la mise en place de la niche pré-métastatique du mélanome : Study of the contractile properties of fibroblasts of the lymph node during the establishment of the pre-metastatic niche of melanoma.” 2020. Doctoral Dissertation, Université Côte d'Azur. Accessed March 03, 2021. http://www.theses.fr/2020COAZ6013.

MLA Handbook (7^th Edition):

Rovera, Christopher. “Étude des propriétés contractiles des fibroblastes du ganglion lymphatique au cours de la mise en place de la niche pré-métastatique du mélanome : Study of the contractile properties of fibroblasts of the lymph node during the establishment of the pre-metastatic niche of melanoma.” 2020. Web. 03 Mar 2021.

Vancouver:

Rovera C. Étude des propriétés contractiles des fibroblastes du ganglion lymphatique au cours de la mise en place de la niche pré-métastatique du mélanome : Study of the contractile properties of fibroblasts of the lymph node during the establishment of the pre-metastatic niche of melanoma. [Internet] [Doctoral dissertation]. Université Côte d'Azur; 2020. [cited 2021 Mar 03]. Available from: http://www.theses.fr/2020COAZ6013.

Council of Science Editors:

Rovera C. Étude des propriétés contractiles des fibroblastes du ganglion lymphatique au cours de la mise en place de la niche pré-métastatique du mélanome : Study of the contractile properties of fibroblasts of the lymph node during the establishment of the pre-metastatic niche of melanoma. [Doctoral Dissertation]. Université Côte d'Azur; 2020. Available from: http://www.theses.fr/2020COAZ6013

University of Otago

6. Al Kharusi, Adil. Lymph nodes as a pre-metastatic niche for oral squamous cell carcinoma .

Degree: University of Otago

URL: http://hdl.handle.net/10523/7724

► Background Pre-metastatic niche (PMN) is a new concept in the process of metastasis defined as tumour microenvironment at the future metastatic site which is established… (more)

Subjects/Keywords: oral cancer; pre-metastatic niche; IL17; IL22; IL23; STAT3

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Al Kharusi, A. (n.d.). Lymph nodes as a pre-metastatic niche for oral squamous cell carcinoma . (Doctoral Dissertation). University of Otago. Retrieved from http://hdl.handle.net/10523/7724

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Chicago Manual of Style (16^th Edition):

Al Kharusi, Adil. “Lymph nodes as a pre-metastatic niche for oral squamous cell carcinoma .” Doctoral Dissertation, University of Otago. Accessed March 03, 2021. http://hdl.handle.net/10523/7724.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

MLA Handbook (7^th Edition):

Al Kharusi, Adil. “Lymph nodes as a pre-metastatic niche for oral squamous cell carcinoma .” Web. 03 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Al Kharusi A. Lymph nodes as a pre-metastatic niche for oral squamous cell carcinoma . [Internet] [Doctoral dissertation]. University of Otago; [cited 2021 Mar 03]. Available from: http://hdl.handle.net/10523/7724.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Council of Science Editors:

Al Kharusi A. Lymph nodes as a pre-metastatic niche for oral squamous cell carcinoma . [Doctoral Dissertation]. University of Otago; Available from: http://hdl.handle.net/10523/7724

Note: this citation may be lacking information needed for this citation format:
No year of publication.

7. Lim, Chetana. Microenvironnement et angiogénèse : implications dans la stratégie onco-chirurgicale des métastases hépatiques synchrones des cancers colorectaux : Microenvironment and angiogenesis : impact on onco-surgical management of synchronous colorectal liver metastases.

Degree: Docteur es, Médecine, 2017, Sorbonne Paris Cité

URL: http://www.theses.fr/2017USPCC018

►

Lors du diagnostic de cancer colorectal, près d’un quart des patients ont des métastases hépatiques dites synchrones. Lorsque la tumeur primitive est asymptomatique, la stratégie… (more)

▼

Lors du diagnostic de cancer colorectal, près d’un quart des patients ont des métastases hépatiques dites synchrones. Lorsque la tumeur primitive est asymptomatique, la stratégie chirurgicale (chirurgie première de la tumeur primitive versus chirurgie première des métastases hépatiques) reste débattue. Les recommandations actuelles ne reposent que sur des accords d’experts qui elles-mêmes sont basées sur des études cliniques rétrospectives. L’étude du microenvironnement tumoral a pris ces dernières années une place majeure dans la recherche sur le cancer. Elle a permis de changer de paradigme avec une nouvelle conception du processus métastatique : une tumeur primitive peut agir sur le microenvironnement du futur site métastatique pour créer une "niche pré-métastatique". Cette niche pré-métastatique permettrait secondairement la croissance des cellules tumorales via une angiogénèse tumorale et la formation de métastases. Par une triple approche à la fois fondamentale, translationnelle et clinique, nous avons obtenu des données qui suggèrent qu’une chirurgie première de la tumeur colique ou rectale permet de moduler l’angiogénèse au sein du microenvironnement hépatique. Cette stratégie chirurgicale permettrait également d’améliorer le pronostic oncologique des malades et l’efficacité des anti-angiogéniques.

At the time of the diagnosis of colorectal cancer, nearly 25% of patients have synchronous liver metastases. When this tumor is asymptomatic, the question of surgical strategy (primary tumor first versus liver-first strategy) remains debated. Current recommendations are based on agreements of experts which are by themselves based on retrospective clinical studies. The study of the tumor microenvironment has taken in recent years a major place in the field of cancer research. It leads to new paradigm with a new conception of the metastatic process. It may be possible that the microenvironment of the metastatic sites can be modulated by the primary tumor to promote the formation of the pre-“metastatic niche”. This leads to promote the growth of cancer cells and increase the metastatic potential of primary tumor. By a multidisciplinary research including fundamental, translational and clinical approaches, we have shown that primary tumor first strategy could modulate tumor angiogenesis and liver metastatic process. It is associated with improved survival of patients and efficacy of the anti-angiogenic therapy.

Advisors/Committee Members: Pocard, Marc (thesis director).

Subjects/Keywords: Niche pré-métastatique; Progéniteurs endothéliaux médullaires; Angiogénèse; Tumeur primitive; Métastases hépatiques synchrones; Foie premier; Pre-metastatic niche; Bone marrow-derived endothelial progenitor cells; Angiogenesis; Synchronous liver metastases; Liver-first strategy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lim, C. (2017). Microenvironnement et angiogénèse : implications dans la stratégie onco-chirurgicale des métastases hépatiques synchrones des cancers colorectaux : Microenvironment and angiogenesis : impact on onco-surgical management of synchronous colorectal liver metastases. (Doctoral Dissertation). Sorbonne Paris Cité. Retrieved from http://www.theses.fr/2017USPCC018

Chicago Manual of Style (16^th Edition):

Lim, Chetana. “Microenvironnement et angiogénèse : implications dans la stratégie onco-chirurgicale des métastases hépatiques synchrones des cancers colorectaux : Microenvironment and angiogenesis : impact on onco-surgical management of synchronous colorectal liver metastases.” 2017. Doctoral Dissertation, Sorbonne Paris Cité. Accessed March 03, 2021. http://www.theses.fr/2017USPCC018.

MLA Handbook (7^th Edition):

Lim, Chetana. “Microenvironnement et angiogénèse : implications dans la stratégie onco-chirurgicale des métastases hépatiques synchrones des cancers colorectaux : Microenvironment and angiogenesis : impact on onco-surgical management of synchronous colorectal liver metastases.” 2017. Web. 03 Mar 2021.

Vancouver:

Lim C. Microenvironnement et angiogénèse : implications dans la stratégie onco-chirurgicale des métastases hépatiques synchrones des cancers colorectaux : Microenvironment and angiogenesis : impact on onco-surgical management of synchronous colorectal liver metastases. [Internet] [Doctoral dissertation]. Sorbonne Paris Cité; 2017. [cited 2021 Mar 03]. Available from: http://www.theses.fr/2017USPCC018.

Council of Science Editors:

Lim C. Microenvironnement et angiogénèse : implications dans la stratégie onco-chirurgicale des métastases hépatiques synchrones des cancers colorectaux : Microenvironment and angiogenesis : impact on onco-surgical management of synchronous colorectal liver metastases. [Doctoral Dissertation]. Sorbonne Paris Cité; 2017. Available from: http://www.theses.fr/2017USPCC018

8. LOW PIN YAN. Tumour-Conditioned Macrophages Up-Regulate Endothelial-Derived Fibronectin to Facilitate Lung Metastasis in Breast Cancer.

Degree: 2015, National University of Singapore

URL: http://scholarbank.nus.edu.sg/handle/10635/119813

Subjects/Keywords: breast cancer; organ-specific metastasis; pre-metastatic niche; tumour-conditioned macrophages; endothelial cells; fibronectin

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APA (6^th Edition):

YAN, L. P. (2015). Tumour-Conditioned Macrophages Up-Regulate Endothelial-Derived Fibronectin to Facilitate Lung Metastasis in Breast Cancer. (Thesis). National University of Singapore. Retrieved from http://scholarbank.nus.edu.sg/handle/10635/119813

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

YAN, LOW PIN. “Tumour-Conditioned Macrophages Up-Regulate Endothelial-Derived Fibronectin to Facilitate Lung Metastasis in Breast Cancer.” 2015. Thesis, National University of Singapore. Accessed March 03, 2021. http://scholarbank.nus.edu.sg/handle/10635/119813.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

YAN, LOW PIN. “Tumour-Conditioned Macrophages Up-Regulate Endothelial-Derived Fibronectin to Facilitate Lung Metastasis in Breast Cancer.” 2015. Web. 03 Mar 2021.

Vancouver:

YAN LP. Tumour-Conditioned Macrophages Up-Regulate Endothelial-Derived Fibronectin to Facilitate Lung Metastasis in Breast Cancer. [Internet] [Thesis]. National University of Singapore; 2015. [cited 2021 Mar 03]. Available from: http://scholarbank.nus.edu.sg/handle/10635/119813.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

YAN LP. Tumour-Conditioned Macrophages Up-Regulate Endothelial-Derived Fibronectin to Facilitate Lung Metastasis in Breast Cancer. [Thesis]. National University of Singapore; 2015. Available from: http://scholarbank.nus.edu.sg/handle/10635/119813

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations