subject:(polyhexanide)

Technical University of Lisbon

1. Cardoso, Joana Raquel Duarte. A polihexanida no controlo de infeções bacterianas e por Malassezia : estudo clínico preliminar no cão.

Degree: 2017, Technical University of Lisbon

URL: https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/13438

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Dissertação de Mestrado Integrado em Medicina Veterinária

As piodermites são consideradas as doenças de pele mais frequentes no cão e a dermatite por Malassezia é… (more)

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Dissertação de Mestrado Integrado em Medicina Veterinária

As piodermites são consideradas as doenças de pele mais frequentes no cão e a dermatite por Malassezia é cada vez mais relevante. O problema das resistências aos antimicrobianos e, em especial, dos estafilococos multirresistentes, tanto em Saúde Animal como em Saúde Humana, torna as opções terapêuticas sistémicas limitadas, imperando uma necessidade de gestão e preservação dos antimicrobianos disponíveis, de pesquisa de alternativas e de proteção da saúde pública. A terapêutica tópica é, assim, cada vez mais privilegiada, sendo a clorexidina o antisséptico mais usado na Dermatologia Veterinária. Já em Medicina Humana a polihexanida é o antisséptico de primeira linha no tratamento de feridas infetadas. Assim, este ensaio clínico randomizado e controlado pretendeu investigar a eficácia de uma solução de polihexanida a 0,1% (Prontosan®, B.Braun Medical, Lda, Portugal) no tratamento de infeções de pele bacterianas e/ou por Malassezia no cão, aplicada uma vez por dia, num máximo de seis semanas e, adicionalmente, comparar essa eficácia à de uma solução de digluconato de clorexidina a 2%. A resposta ao tratamento foi definida pela progressão de um score clínico e citológico atribuídos segundo escalas de, respetivamente, três e quatro pontos, sendo também registada a opinião dos donos. Com a utilização da polihexanida foi observada uma melhoria clínica em 75% (6/8) dos doentes com pelo menos uma consulta de seguimento vs. 60% (6/10) no grupo da clorexidina. Houve uma melhoria clínica de pelo menos 50% associada a cura citológica em metade dos doentes tratados com polihexanida, que alcançaram a cura clínica entre os 14 e 31 dias vs. 21 dias para o único doente que atingiu cura clínica com a clorexidina. A cura citológica foi mais frequente que a cura clínica em ambos os grupos e ocorreu entre os dias 7 e 24 para a polihexanida vs. 8 e 22 para a clorexidina. Os resultados sugerem que a polihexanida é eficaz no tratamento de algumas piodermites, com ou sem sobrecrescimento de Malassezia, sendo muito bem tolerada. A sua eficácia parece ser pelo menos semelhante à da clorexidina e, além disso, não se observaram reações adversas. Isto pode indicar uma vantagem sobre a clorexidina, que, neste estudo, esteve implicada numa dermatite de contacto. A investigação relativa à polihexanida nesta área pode e deve continuar. Considerando os seus atributos de promoção da cicatrização e os resultados positivos deste estudo seria importante avaliar a sua utilização em piodermites profundas. Há, todavia, uma grande falta de conhecimento sobre as consequências da exposição prolongada e subterapêutica dos microrganismos a estes antissépticos.

ABSTRACT - POLYHEXANIDE IN THE TREATMENT OF PYODERMA AND MALASSEZIA DERMATITIS: PRELIMINARY CLINICAL TRIAL IN THE DOG - Pyoderma is considered the most frequent skin disease in the dog and Malassezia dermatitis is increasingly relevant. The problem of antimicrobial resistance and specially the multirresistant staphylococci in both Animal and…

Advisors/Committee Members: Lourenço, Ana Mafalda Gonçalves Xavier Félix.

Subjects/Keywords: polihexanida; infeções cutâneas; piodermite; Malassezia; tratamento tópico; ensaio clínico; polyhexanide; skin infections; pyoderma; topical treatment; clinical trial

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cardoso, J. R. D. (2017). A polihexanida no controlo de infeções bacterianas e por Malassezia : estudo clínico preliminar no cão. (Thesis). Technical University of Lisbon. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/13438

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cardoso, Joana Raquel Duarte. “A polihexanida no controlo de infeções bacterianas e por Malassezia : estudo clínico preliminar no cão.” 2017. Thesis, Technical University of Lisbon. Accessed January 19, 2021. https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/13438.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cardoso, Joana Raquel Duarte. “A polihexanida no controlo de infeções bacterianas e por Malassezia : estudo clínico preliminar no cão.” 2017. Web. 19 Jan 2021.

Vancouver:

Cardoso JRD. A polihexanida no controlo de infeções bacterianas e por Malassezia : estudo clínico preliminar no cão. [Internet] [Thesis]. Technical University of Lisbon; 2017. [cited 2021 Jan 19]. Available from: https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/13438.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cardoso JRD. A polihexanida no controlo de infeções bacterianas e por Malassezia : estudo clínico preliminar no cão. [Thesis]. Technical University of Lisbon; 2017. Available from: https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/13438

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

2. Vörös, Pauline. Einfluss von Antiseptika auf humane Osteoblasten in vitro.

Degree: 2015, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-9916

► Hintergrund. Antiseptika sind hochpotente Agenzien, die in der Wundbehandlung und Dekontamination zur Anwendung kommen und besitzen ein großes Potential für die Verwendung in der septischen… (more)

Subjects/Keywords: human osteoblasts; antiseptics; chlorhexidine; polyhexanide; periprosthetic joint infection; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vörös, P. (2015). Einfluss von Antiseptika auf humane Osteoblasten in vitro. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-9916

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vörös, Pauline. “Einfluss von Antiseptika auf humane Osteoblasten in vitro.” 2015. Thesis, Freie Universität Berlin. Accessed January 19, 2021. http://dx.doi.org/10.17169/refubium-9916.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vörös, Pauline. “Einfluss von Antiseptika auf humane Osteoblasten in vitro.” 2015. Web. 19 Jan 2021.

Vancouver:

Vörös P. Einfluss von Antiseptika auf humane Osteoblasten in vitro. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2021 Jan 19]. Available from: http://dx.doi.org/10.17169/refubium-9916.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vörös P. Einfluss von Antiseptika auf humane Osteoblasten in vitro. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-9916

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

3. Dähn-Wollenberg, Stephanie. The effect of antiseptics on human chondrocytes in vitro.

Degree: 2012, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-11471

► The use of antiseptics as a treatment for septic arthritis has been discussed controversially because of their possible cytotoxic effects on chondrocytes. Because of the… (more)

Subjects/Keywords: Antiseptics; Polyhexanide; Hydrogen carboxide; in vitro; Chondrocytes; Apoptosis; Necrosis; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dähn-Wollenberg, S. (2012). The effect of antiseptics on human chondrocytes in vitro. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-11471

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dähn-Wollenberg, Stephanie. “The effect of antiseptics on human chondrocytes in vitro.” 2012. Thesis, Freie Universität Berlin. Accessed January 19, 2021. http://dx.doi.org/10.17169/refubium-11471.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dähn-Wollenberg, Stephanie. “The effect of antiseptics on human chondrocytes in vitro.” 2012. Web. 19 Jan 2021.

Vancouver:

Dähn-Wollenberg S. The effect of antiseptics on human chondrocytes in vitro. [Internet] [Thesis]. Freie Universität Berlin; 2012. [cited 2021 Jan 19]. Available from: http://dx.doi.org/10.17169/refubium-11471.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dähn-Wollenberg S. The effect of antiseptics on human chondrocytes in vitro. [Thesis]. Freie Universität Berlin; 2012. Available from: http://dx.doi.org/10.17169/refubium-11471

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

4. Strobel, Rahel Maria. Reduktion postoperativer Wundinfektionen durch Antiseptika? (RECIPE).

Degree: 2019, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-25961

► Objective To evaluate whether intraoperative subcutaneous wound irrigation with 0.04% polyhexanide can reduce surgical site infection (SSI) in elective laparotomies compared to 0.9% saline. Background… (more)

▼ Objective To evaluate whether intraoperative subcutaneous wound irrigation with 0.04% polyhexanide can reduce surgical site infection (SSI) in elective laparotomies compared to 0.9% saline. Background SSI is a common complication after visceral surgery causing increased morbidity and postoperative pain. Many surgical departments conduct subcutaneous wound irrigation before skin closure to reduce SSI although there is a lack of high-level evidence on its benefit. Methods The RECIPE trial was an investigator initiated single centre, single blind, prospective, randomized controlled trial with two parallel treatment groups, comparing intraoperative subcutaneous wound irrigation with 0.9% saline to antiseptic 0.04% polyhexanide solution in elective laparotomies. The primary endpoint was the rate of SSI within 30 days postoperatively according to Center for Disease Control (CDC) criteria. Secondary endpoints were colonization of abdominal wall with pathogens, length of hospital stay, postoperative pain and cosmetic result. Results Between Feb 02, 2015, and May 23, 2018, 456 patients were randomly assigned to saline (n = 228) or polyhexanide (n = 228), of whom 393 patients (202 in the saline and 191 in the polyhexanide group) were analyzed per-protocol. Overall, we detected 111 (28.2%) SSIs. Simple analysis with cross tabulation revealed that significantly fewer SSIs occurred in the polyhexanide group: n = 70 (34.7%) vs. n = 41 (21.5%); p = 0.004. In a multiple logistic regression model the factor subcutaneous wound irrigation with polyhexanide (OR 0.44; 95% CI 0.27 – 0.72; p = 0.001) was associated with risk reduction of SSI. Preoperative anaemia (OR 2.08; 95% CI 1.27 – 3.40; p = 0.004) and more than five prior abdominal operations compared to zero (OR 8.51; 95% CI 2.57 – 28.21; p < 0.001) were also associated with SSI. There were significantly fewer positive intraoperative swabs of the subcutaneous tissue after irrigation with polyhexanide: n= 107 (67.7%) vs. n = 35 (21.6%); p < 0.001. Conclusion Intraoperative subcutaneous wound irrigation with antiseptic 0.04% polyhexanide solution reduces SSIs after elective laparotomies for visceral surgery compared to 0.9% saline. Advisors/Committee Members: female (gender), N.N. (firstReferee), N.N. (furtherReferee).

Subjects/Keywords: visceral surgery; antiseptica; polyhexanide; surgical site infection; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

…subcutaneous wound irrigation with 0.04% polyhexanide can reduce surgical site infection (SSI… …saline to antiseptic 0.04% polyhexanide solution in elective laparotomies. The primary endpoint… …polyhexanide (n = 228), of whom 393 patients (202 in the saline and 191 in the… …polyhexanide group) were analyzed per-protocol. Overall, we detected 111 (28.2%) SSIs… …polyhexanide group: n = 70 (34.7%) vs. n = 41 (21.5%); p = 0.004. In a multiple…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Strobel, R. M. (2019). Reduktion postoperativer Wundinfektionen durch Antiseptika? (RECIPE). (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-25961

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Strobel, Rahel Maria. “Reduktion postoperativer Wundinfektionen durch Antiseptika? (RECIPE).” 2019. Thesis, Freie Universität Berlin. Accessed January 19, 2021. http://dx.doi.org/10.17169/refubium-25961.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Strobel, Rahel Maria. “Reduktion postoperativer Wundinfektionen durch Antiseptika? (RECIPE).” 2019. Web. 19 Jan 2021.

Vancouver:

Strobel RM. Reduktion postoperativer Wundinfektionen durch Antiseptika? (RECIPE). [Internet] [Thesis]. Freie Universität Berlin; 2019. [cited 2021 Jan 19]. Available from: http://dx.doi.org/10.17169/refubium-25961.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Strobel RM. Reduktion postoperativer Wundinfektionen durch Antiseptika? (RECIPE). [Thesis]. Freie Universität Berlin; 2019. Available from: http://dx.doi.org/10.17169/refubium-25961

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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