subject:(polyethylene glycol)

Oregon State University

1. Luh, Song-ping. The cloud point composition and flory-huggins interaction parameters of polyethylene glycol and sodium lignin sulfonate in water-ethanol mixtures.

Degree: MS, Chemical Engineering, 1987, Oregon State University

URL: http://hdl.handle.net/1957/39383

► In designing a solubility based separation process for solvent recovery of an organosolv pulping process, the phase behavior of polymeric lignin molecules in alcohol -… (more)

Subjects/Keywords: Polyethylene glycol

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APA (6^th Edition):

Luh, S. (1987). The cloud point composition and flory-huggins interaction parameters of polyethylene glycol and sodium lignin sulfonate in water-ethanol mixtures. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/39383

Chicago Manual of Style (16^th Edition):

Luh, Song-ping. “The cloud point composition and flory-huggins interaction parameters of polyethylene glycol and sodium lignin sulfonate in water-ethanol mixtures.” 1987. Masters Thesis, Oregon State University. Accessed February 28, 2021. http://hdl.handle.net/1957/39383.

MLA Handbook (7^th Edition):

Luh, Song-ping. “The cloud point composition and flory-huggins interaction parameters of polyethylene glycol and sodium lignin sulfonate in water-ethanol mixtures.” 1987. Web. 28 Feb 2021.

Vancouver:

Luh S. The cloud point composition and flory-huggins interaction parameters of polyethylene glycol and sodium lignin sulfonate in water-ethanol mixtures. [Internet] [Masters thesis]. Oregon State University; 1987. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1957/39383.

Council of Science Editors:

Luh S. The cloud point composition and flory-huggins interaction parameters of polyethylene glycol and sodium lignin sulfonate in water-ethanol mixtures. [Masters Thesis]. Oregon State University; 1987. Available from: http://hdl.handle.net/1957/39383

Michigan State University

2. Lien, Yu Ling. Poly(ethylene glycol)-based materials as nanocarriers for small molecules and macromolecules.

Degree: 2015, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:2502

►

Thesis M.S. Michigan State University. Chemistry 2015

Nanocarriers, the use of nanoparticles as a transport module for another substance, has been widely studied for their… (more)

▼

Thesis M.S. Michigan State University. Chemistry 2015

Nanocarriers, the use of nanoparticles as a transport module for another substance, has been widely studied for their applications in biomedical and pharmaceutical fields. Prepared nanocarriers from unimolecular polymeric micelle has caught most of our attention in this area. In our previous research, we have synthesized biocompatible and biodegradable poly(propargyl glycolide) (PPGL) polymer and its grafting derivatives and studied their ability to form unimolecular micelles and be used as nanocarriers. Moreover, the encapsulation of macromolecules using PPGL derivatives has inspired the thought of utilizing these materials as artificial chaperones for assisting protein refolding. However, the degradability of PPGL derivatives makes long-term study difficult; hence, synthesizing poly(ethylene glycol) (PEG) based analog will help us to further understand the role of degradability in PPGL derivatives and to design the materials based on the needs.A series of PEG-based alkyne-functionalized polymers have been synthesized using a tetraoctylammonium bromide-triisobutylaluminum initiating system and the relationship between [monomer]/[initiator] ratio and molecular weights was studied. By increasing [monomer]/[initiator] ratio, the molecular weight of the resulting polymer also increases. In addition, copper(I)-catalyzed 1,3-dipolar cycloaddition of azides and alkynes "click" chemistry was used for the post-polymerization modification of these polymers. Water-soluble polymers that show lower critical solution temperature (LCST) behavior were obtained by varying the ratio between mDEG and decyl side chains. A relationship between cloud point temperatures and mol% mDEG in polymer was observed. Significantly, the LCST results were comparable with our previous research. Therefore, a conclusion could be drawn that the LCST behavior is related to the nature of the side chains rather than the nature of the polymer backbone. Preliminary results have shown that these "click" modified PEG-base polymers have the ability to form unimolecular micelles and to encapsulate azobenzene. These results show that the newly synthesized PEG-based polymers have common properties as PPGL-based polymers.

Description based on online resource;

Advisors/Committee Members: Smith, Milton R, Huang, Xuefei, Geiger, James, Beaulac, Remi.

Subjects/Keywords: Polyethylene glycol – Biotechnology; Nanoparticles; Chemistry

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APA (6^th Edition):

Lien, Y. L. (2015). Poly(ethylene glycol)-based materials as nanocarriers for small molecules and macromolecules. (Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:2502

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lien, Yu Ling. “Poly(ethylene glycol)-based materials as nanocarriers for small molecules and macromolecules.” 2015. Thesis, Michigan State University. Accessed February 28, 2021. http://etd.lib.msu.edu/islandora/object/etd:2502.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lien, Yu Ling. “Poly(ethylene glycol)-based materials as nanocarriers for small molecules and macromolecules.” 2015. Web. 28 Feb 2021.

Vancouver:

Lien YL. Poly(ethylene glycol)-based materials as nanocarriers for small molecules and macromolecules. [Internet] [Thesis]. Michigan State University; 2015. [cited 2021 Feb 28]. Available from: http://etd.lib.msu.edu/islandora/object/etd:2502.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lien YL. Poly(ethylene glycol)-based materials as nanocarriers for small molecules and macromolecules. [Thesis]. Michigan State University; 2015. Available from: http://etd.lib.msu.edu/islandora/object/etd:2502

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Georgia

3. Sardar, Radha Rajeev. Study of the physico-chemical properties of macromolecular assemblies.

Degree: 2014, University of Georgia

URL: http://hdl.handle.net/10724/28598

► Block copolymers are a diverse group of macromolecules that have attracted a great deal of attention due to their ability to self-assemble into a variety… (more)

▼ Block copolymers are a diverse group of macromolecules that have attracted a great deal of attention due to their ability to self-assemble into a variety of nanostructures. These nanostructures can be tuned over a wide range of morphologies and hence can be used in a plethora of applications ranging from delivery platforms for drugs and genes to nanosized reactors. Block copolymers, primarily used for drug delivery applications, consist of at least one hydrophobic and one hydrophilic polymer chain that are covalently linked to one another. There are many factors that play a role in determining the morphology of the self-assembled molecule for example, the nature and length of the polar hydrophilic group, the length of the hydrophobic polymer, temperature and the type of common solvent employed during the self-assembly. The first project involved the synthesis and self-assembly of micelles using amphiphilic blocks copolymers like polyethylene glycol (PEG) and polycaprolactone (PCL) with different PEG and PCL lengths. These polymers showed good correlation between the molecular weights obtained from gel permeation chromatography (GPC) and nuclear magnetic resonance (NMR). We next demonstrated that by varying the individual components of the block copolymers, we could systematically change the micelles’ physico-chemical property like size. The study of the corresponding micelles showed that there was a slight increase in size with the increase of hydrophobic, PCL length, while a significant increase in the size was observed with the decrease of hydrophilic - PEG length. A single study on a selected PEG-PCL polymeric micelle using atomic force microscopy (AFM) analysis and click chemistry revealed the force required to destabilize the micelles by pulling the single polymer chain is 47pN. The next study involved replacing the hydrophilic PEG with a sugar moiety and conducting similar study on the relationship of the block length and molecular weight on the morphology of the micelles. The synthesis of the polysaccharide based block copolymers was done by employing the copper-(I)-catalyzed azide-alkyne cycloaddition. It was observed that when lactose was used as the hydrophilic block, the micelles obtained were unstable. Synthesis of higher sugar analogues was proposed using Lewis acid mediated acetolysis of -cyclodextrin. However, attempts to further modify the polysaccharide were futile and the synthesis of the higher analogues is still underway.

Subjects/Keywords: Polyethylene glycol; Polycaprolactone; Micelle; Click reaction

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APA (6^th Edition):

Sardar, R. R. (2014). Study of the physico-chemical properties of macromolecular assemblies. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/28598

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sardar, Radha Rajeev. “Study of the physico-chemical properties of macromolecular assemblies.” 2014. Thesis, University of Georgia. Accessed February 28, 2021. http://hdl.handle.net/10724/28598.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sardar, Radha Rajeev. “Study of the physico-chemical properties of macromolecular assemblies.” 2014. Web. 28 Feb 2021.

Vancouver:

Sardar RR. Study of the physico-chemical properties of macromolecular assemblies. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10724/28598.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sardar RR. Study of the physico-chemical properties of macromolecular assemblies. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/28598

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Vanderbilt University

4. Salzman, Michele Marie. Poloxamer 188 Protects Isolated Mouse Cardiomyocytes from Hypoxia/Reoxygenation Injury - Implications for Cardioprotection after Cardiac Arrest.

Degree: MS, Pharmacology, 2017, Vanderbilt University

URL: http://hdl.handle.net/1803/15083

► Cardiac arrest is a leading cause of death. Even with the best cardiopulmonary resuscitation (CPR), many patients still die or suffer severe organ damage. The… (more)

Subjects/Keywords: polyethylene glycol (PEG); FM1-43; Fluo-4

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Salzman, M. M. (2017). Poloxamer 188 Protects Isolated Mouse Cardiomyocytes from Hypoxia/Reoxygenation Injury - Implications for Cardioprotection after Cardiac Arrest. (Thesis). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/15083

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Salzman, Michele Marie. “Poloxamer 188 Protects Isolated Mouse Cardiomyocytes from Hypoxia/Reoxygenation Injury - Implications for Cardioprotection after Cardiac Arrest.” 2017. Thesis, Vanderbilt University. Accessed February 28, 2021. http://hdl.handle.net/1803/15083.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Salzman, Michele Marie. “Poloxamer 188 Protects Isolated Mouse Cardiomyocytes from Hypoxia/Reoxygenation Injury - Implications for Cardioprotection after Cardiac Arrest.” 2017. Web. 28 Feb 2021.

Vancouver:

Salzman MM. Poloxamer 188 Protects Isolated Mouse Cardiomyocytes from Hypoxia/Reoxygenation Injury - Implications for Cardioprotection after Cardiac Arrest. [Internet] [Thesis]. Vanderbilt University; 2017. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1803/15083.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Salzman MM. Poloxamer 188 Protects Isolated Mouse Cardiomyocytes from Hypoxia/Reoxygenation Injury - Implications for Cardioprotection after Cardiac Arrest. [Thesis]. Vanderbilt University; 2017. Available from: http://hdl.handle.net/1803/15083

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

5. Burton, Charles Dean. Derivatives of an unsaturated polyester-polyethylene glycol maleate.

Degree: MS, 1948, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:9881

Subjects/Keywords: Polyethylene glycol maleate

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Burton, C. D. (1948). Derivatives of an unsaturated polyester-polyethylene glycol maleate. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:9881

Chicago Manual of Style (16^th Edition):

Burton, Charles Dean. “Derivatives of an unsaturated polyester-polyethylene glycol maleate.” 1948. Masters Thesis, Michigan State University. Accessed February 28, 2021. http://etd.lib.msu.edu/islandora/object/etd:9881.

MLA Handbook (7^th Edition):

Burton, Charles Dean. “Derivatives of an unsaturated polyester-polyethylene glycol maleate.” 1948. Web. 28 Feb 2021.

Vancouver:

Burton CD. Derivatives of an unsaturated polyester-polyethylene glycol maleate. [Internet] [Masters thesis]. Michigan State University; 1948. [cited 2021 Feb 28]. Available from: http://etd.lib.msu.edu/islandora/object/etd:9881.

Council of Science Editors:

Burton CD. Derivatives of an unsaturated polyester-polyethylene glycol maleate. [Masters Thesis]. Michigan State University; 1948. Available from: http://etd.lib.msu.edu/islandora/object/etd:9881

Rutgers University

6. Gu, Zichao, 1985-. Molecular-size effects of poly(ethylene glycol) doxorubicin nanocarriers on the intraductal treatment of ductal carcinoma in situ (dcis).

Degree: PhD, Pharmaceutical Science, 2015, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/46351/

►

Systemic chemotherapy is not a first-line treatment option for early stage breast cancer due primarily to the limited blood supply in mammary ducts and the… (more)

▼

Systemic chemotherapy is not a first-line treatment option for early stage breast cancer due primarily to the limited blood supply in mammary ducts and the variable and limited drug concentration reaching to the tumor within the ducts. To enhance local drug concentration and avoid excess systemic exposure, an intraductal approach for delivering the anti-cancer agents directly to mammary glands provides an alternative method for treating DCIS. Doxorubicin (DOX) is a widely used anti-cancer drug but it rapidly diffuses from the mammary gland into the systemic circulation. Therefore, techniques for retaining drugs locally in the mammary gland are needed. The objective of this thesis project is to design, develop, and evaluate breast intraductal drug delivery systems that provide higher drug retention in the mammary gland, thereby minimizing systemic exposure and achieving maximal local therapeutic effect. PEG polymers with different molecular weights (5, 10, 20 and 40 kDa) and molecular architectures (linear, four-arm and eight-arm) were conjugated to DOX to develop PEG DOX (PEG-DOX) nanocarriers. The hydrodynamic radii studies showed the hydrodynamic radii increased with increasing molecular weight for the linear PEGs and decreased with increased branching in the polymer structure. The mammary gland retention half-lives demonstrated the influence of molecular weight and structure of nanocarriers on mammary gland retention. Pharmacokinetic profiles indicated that nanocarriers with longer retention half-life tend to distribute into the blood stream with a delayed plasma peak time. Histological studies showed no local damage or inflammation in the nanocarrier treated mammary gland, but altered ductal structure was observed in DOX treated mammary gland. A F344 tumor model, developed by inoculating 13762 Mat B III cells into female F344 rats intraductally, exhibited cell load- and time-dependent tumor development in the rats. Efficacy studies demonstrated slower tumor growth in the intraductal treatment groups than in the intravenous treatment groups. The survival rate in the intraductal treatment groups was significant higher than the untreated group. In summary, the developed PEG-DOX nanocarriers improved DOX retention and reduced DOX toxicity in mammary gland, leading to a significantly improved survival percentage in treating DCIS in a F344 tumor rat model.

Advisors/Committee Members: Sinko, Patrick (chair), Michniak, Bozena (internal member), You, Guofeng (internal member), Love, Susan (outside member).

Subjects/Keywords: Polyethylene glycol; Breast – Cancer; Drug delivery systems

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gu, Zichao, 1. (2015). Molecular-size effects of poly(ethylene glycol) doxorubicin nanocarriers on the intraductal treatment of ductal carcinoma in situ (dcis). (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/46351/

Chicago Manual of Style (16^th Edition):

Gu, Zichao, 1985-. “Molecular-size effects of poly(ethylene glycol) doxorubicin nanocarriers on the intraductal treatment of ductal carcinoma in situ (dcis).” 2015. Doctoral Dissertation, Rutgers University. Accessed February 28, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/46351/.

MLA Handbook (7^th Edition):

Gu, Zichao, 1985-. “Molecular-size effects of poly(ethylene glycol) doxorubicin nanocarriers on the intraductal treatment of ductal carcinoma in situ (dcis).” 2015. Web. 28 Feb 2021.

Vancouver:

Gu, Zichao 1. Molecular-size effects of poly(ethylene glycol) doxorubicin nanocarriers on the intraductal treatment of ductal carcinoma in situ (dcis). [Internet] [Doctoral dissertation]. Rutgers University; 2015. [cited 2021 Feb 28]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/46351/.

Council of Science Editors:

Gu, Zichao 1. Molecular-size effects of poly(ethylene glycol) doxorubicin nanocarriers on the intraductal treatment of ductal carcinoma in situ (dcis). [Doctoral Dissertation]. Rutgers University; 2015. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/46351/

Ryerson University

7. Cruje, Charmainne. Enhanced uptake of polyethylene glycol coated gold nanoparticles for improved therapeutics.

Degree: 2015, Ryerson University

URL: https://digital.library.ryerson.ca/islandora/object/RULA%3A3705

► Polyethylene glycol (PEG) has promoted the prospective cancer treatment applications of gold nanoparticles (GNPs). PEG is widely used in providing GNPs with stealth properties, hence… (more)

Subjects/Keywords: Polyethylene glycol – Therapeutic use; Nanoparticles – Therapeutic use; Cancer – Treatment; Polyethylene glycol – Biotechnology; Nanobiotechnology; Gold

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cruje, C. (2015). Enhanced uptake of polyethylene glycol coated gold nanoparticles for improved therapeutics. (Thesis). Ryerson University. Retrieved from https://digital.library.ryerson.ca/islandora/object/RULA%3A3705

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cruje, Charmainne. “Enhanced uptake of polyethylene glycol coated gold nanoparticles for improved therapeutics.” 2015. Thesis, Ryerson University. Accessed February 28, 2021. https://digital.library.ryerson.ca/islandora/object/RULA%3A3705.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cruje, Charmainne. “Enhanced uptake of polyethylene glycol coated gold nanoparticles for improved therapeutics.” 2015. Web. 28 Feb 2021.

Vancouver:

Cruje C. Enhanced uptake of polyethylene glycol coated gold nanoparticles for improved therapeutics. [Internet] [Thesis]. Ryerson University; 2015. [cited 2021 Feb 28]. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A3705.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cruje C. Enhanced uptake of polyethylene glycol coated gold nanoparticles for improved therapeutics. [Thesis]. Ryerson University; 2015. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A3705

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

8. Kalldin, Sofie. Lamination of Organic Solar Modules.

Degree: The Institute of Technology, 2014, Linköping UniversityLinköping University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-105629

► As the Worlds energy demand is increasing we need more of our energy to be generated from resources that affect the climate as little… (more)

Subjects/Keywords: Organic solar modules; Lamination; PEDOT:PSS; Ethylene Glycol (EG); Diethylene Glycol (DEG); Polyethylene Glycol (PEG); Roll to roll process (R2R)

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APA (6^th Edition):

Kalldin, S. (2014). Lamination of Organic Solar Modules. (Thesis). Linköping UniversityLinköping University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-105629

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kalldin, Sofie. “Lamination of Organic Solar Modules.” 2014. Thesis, Linköping UniversityLinköping University. Accessed February 28, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-105629.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kalldin, Sofie. “Lamination of Organic Solar Modules.” 2014. Web. 28 Feb 2021.

Vancouver:

Kalldin S. Lamination of Organic Solar Modules. [Internet] [Thesis]. Linköping UniversityLinköping University; 2014. [cited 2021 Feb 28]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-105629.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kalldin S. Lamination of Organic Solar Modules. [Thesis]. Linköping UniversityLinköping University; 2014. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-105629

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

9. Chen, Po-yun. Hexaazatrinaphthaline Polyether-Polymer-Lithium Ion Hybrid: Mesophase Stability and Potential Application.

Degree: Master, Chemistry, 2016, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0808116-152728

► In this thesis, we synthesized hexaazatrinaphthylene containing six triethylene glycol side chains (HATN-TEG) for application as potential electrolytes for lithium-ion. Our initial studies involved doping… (more)

Subjects/Keywords: impedance; hydrophilic; hydrophobic; doping; polyethylene glycol; phase segregation; ion channel

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APA (6^th Edition):

Chen, P. (2016). Hexaazatrinaphthaline Polyether-Polymer-Lithium Ion Hybrid: Mesophase Stability and Potential Application. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0808116-152728

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chen, Po-yun. “Hexaazatrinaphthaline Polyether-Polymer-Lithium Ion Hybrid: Mesophase Stability and Potential Application.” 2016. Thesis, NSYSU. Accessed February 28, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0808116-152728.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chen, Po-yun. “Hexaazatrinaphthaline Polyether-Polymer-Lithium Ion Hybrid: Mesophase Stability and Potential Application.” 2016. Web. 28 Feb 2021.

Vancouver:

Chen P. Hexaazatrinaphthaline Polyether-Polymer-Lithium Ion Hybrid: Mesophase Stability and Potential Application. [Internet] [Thesis]. NSYSU; 2016. [cited 2021 Feb 28]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0808116-152728.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chen P. Hexaazatrinaphthaline Polyether-Polymer-Lithium Ion Hybrid: Mesophase Stability and Potential Application. [Thesis]. NSYSU; 2016. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0808116-152728

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Ryerson University

10. Al Rafea, Kamal. Solubility measurement of polyethylene glycol polymers in supercritical carbon dioxide at high pressures and temperatures.

Degree: 2008, Ryerson University

URL: https://digital.library.ryerson.ca/islandora/object/RULA%3A632

► Solubility and its measurement of different materials including polymers, drugs, proteins, peptides and many other organic or non organic compounds in supercritical fluids are of… (more)

▼ Solubility and its measurement of different materials including polymers, drugs, proteins, peptides and many other organic or non organic compounds in supercritical fluids are of great importance in a wide variety of applications. These applications include: production of controlled drug delivery systems, powder processing, pollution prevention, spraying paints and coatings, and food processing.Supercritical fluids are getting more interest since the last two decades due to their abilities in replacing VOC solvents, and because of their tunable properties that could be achieved by varying their pressure and temperature in getting powerful solvents. Supercritical fluid is a substance under pressure above its critical temperture. Under supercritical conditions the distinction between gases and liquids does not apply and substnace can only be described as a fluid. Superciritical fluides have properties intermediate between those of gases and liquids, controlled by the pressure. They do not condense or evaporate to form a liquid or a gas. Fluids such as supercritical carbon dioxide offer a range of unusual chemicla possibilites in both synthetic and analytical chemistry. Supercritical fluids have solvent poer similar to a light hydrocarbon for most solutes.Carbon Dioxide as supercritical fluid is the msot common and useful sovlent in dissolving different kinds of materials because of its unique features like non toxicity, inflammability, its low critical pressure and critical temperature values, and its low cost. By adjusting the pressure and temperature of Carbon Dioxide above its Pc and Tc, we can modify its powerful to dissolve materials such as Polymers, Drugs, Proteins, and other organic and non organic materials.Polyethylene Glycol polymers have a low toxicity and they are used in a wide variety of products. As a biodegradable polymer, PEG can be used alone or with other biogdegradable polymers as a drug career into humans and/or animals bodies after getting dissolve with the compatible drugs or proteins in supercritical carbon dioxide.The solubility of Peg of different molecular weights (PEG 600, PEG 1500 , PEG 6000, and PEG 12000) in Supercritical Carbon Dioxide is measured at different pressures (from 15 to 50 Mpa) and at temperatures (from 313 to 366 K). Also the saturation time that needed to reach the equilibrium state between the polymer and the supercritical fluid at the desired conditions is estimated. In general, the solubility of PEG in SC C0₂ increased with pressure and decreased with temperature due to the density effect of SC CO₂ which is increasing with pressure and decreasing with temperature. Almost PEG of different molecular weights is follow the same solubility pattern.Static method is used to measure the PEG solubility and the measurement is analyzed by using a microgram scale and this method is compared with other methods.Low molecular weight PEG polymers have higher solubility than that of high molecular weight polymers at the same supercritical conditions of P, V, and T. Mixing process was… Advisors/Committee Members: Lohi, A (Thesis advisor), Upreti, S (Thesis advisor), Wu, J (Thesis advisor), Ryerson University (Degree grantor).

Subjects/Keywords: Polyethylene glycol; Solubility; Supercritical fluids

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APA (6^th Edition):

Al Rafea, K. (2008). Solubility measurement of polyethylene glycol polymers in supercritical carbon dioxide at high pressures and temperatures. (Thesis). Ryerson University. Retrieved from https://digital.library.ryerson.ca/islandora/object/RULA%3A632

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Al Rafea, Kamal. “Solubility measurement of polyethylene glycol polymers in supercritical carbon dioxide at high pressures and temperatures.” 2008. Thesis, Ryerson University. Accessed February 28, 2021. https://digital.library.ryerson.ca/islandora/object/RULA%3A632.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Al Rafea, Kamal. “Solubility measurement of polyethylene glycol polymers in supercritical carbon dioxide at high pressures and temperatures.” 2008. Web. 28 Feb 2021.

Vancouver:

Al Rafea K. Solubility measurement of polyethylene glycol polymers in supercritical carbon dioxide at high pressures and temperatures. [Internet] [Thesis]. Ryerson University; 2008. [cited 2021 Feb 28]. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A632.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Al Rafea K. Solubility measurement of polyethylene glycol polymers in supercritical carbon dioxide at high pressures and temperatures. [Thesis]. Ryerson University; 2008. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A632

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

11. Vieira Junior, Manoel Carlos. Preparo de cólon para realização de colonoscopia: estudo prospectivo randomizado comparativo entre solução de polietilenoglicol baixo volume mais bisacodil versus solução de manitol mais bisacodil.

Degree: Mestrado, Gastroenterologia Clínica, 2011, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5147/tde-02122011-110656/ ;

►

A colonoscopia é atualmente o padrão ouro para investigação da mucosa dos cólons, reto e íleo terminal. Para sua realização, há necessidade de uso de… (more)

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A colonoscopia é atualmente o padrão ouro para investigação da mucosa dos cólons, reto e íleo terminal. Para sua realização, há necessidade de uso de soluções para limpeza do cólon que, em geral, são mal toleradas pelos pacientes. Os objetivos do presente estudo foram comparar duas soluções de preparo intestinal para colonoscopia, quanto à efetividade, tolerabilidade, aceitabilidade e segurança em pacientes que se submeteriam a colonoscopia eletivamente, no Centro de Diagnóstico em Gastroenterologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo. Trata-se de estudo unicêntrico, prospectivo, com alocação aleatória dos pacientes. Cem pacientes pareados por sexo e idade foram randomizados em dois grupos. O grupo I recebeu bisacodil mais 1 litro de Polietilenoglicol (PEG) na véspera e 1 litro no dia do exame. O grupo II recebeu bisacodil na véspera e 1 litro de manitol 10% no dia do exame. A mesma dieta foi orientada nos dois grupos. A qualidade do preparo foi graduada através das escalas de Boston e Ottawa. A tolerabilidade e aceitabilidade foram aferidas por questionários previamente estudados. Quanto à segurança, foram ava liadas: variação de sinais vitais antes e após o preparo e complicações. Noventa e seis pacientes (96%) completaram o estudo. Não se observou diferença na qualidade do preparo entre os grupos(p = 0,059). Quanto à tolerabilidade, o grupo I (PEG) apresentou frequência significativamente menor de náusea, vômito, dor abdominal e distensão abdominal (p < 0,05). A aceitabilidade foi significativamente melhor com o grupo I (PEG) (p < 0,05). Em relação à segurança, o grupo I (PEG) apresentou-se mais seguro. No presente estudo, podemos concluir que ambos os preparos são semelhantes em eficácia (p > 0,05) e a solução de PEG apresentou melhor tolerabilidade, aceitabilidade e segurança em comparação ao preparo com manitol (p < 0,05).

Colonoscopy is currently the gold standard to examine the colon, the rectum, and the terminal ileum. To perform a colonoscopy, is necessary to use solutions to clean the colon that are generally poorly tolerated by the patients. The study aims to compare the effectiveness, tolerability, acceptability and safety of two solutions used for intestinal preparation for elective colonoscopy examination in the Diagnosis Center Of Hospital das Clinicas, Faculty of Medicine, University of São Paulo. It is a Prospective study carried out in a single center, with random allocation of the patients. One hundred patients that were paired based on sex and age were randomized into two groups. Group I received bisacodyl plus 1 liter of polyethylene glycol (PEG) the night before and 1 liter on the day of the exam. Group II received bisacodyl the night before and 1 liter of a 10% mannitol solution on the day of the exam. The patients diet was the same for both groups. The quality of the preparation was graded based on the Boston and Ottawa scales. Tolerability and acceptability were measured using previously validated questionnaires. In terms of safety, variations in…

Advisors/Committee Members: Hashimoto, Claudio Lyoiti.

Subjects/Keywords: Bisacodil; Bisacodyl; Colonoscopia; Colonoscopy; Manitol; Mannitol; Polietilenoglicois; Polyethylene glycol

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vieira Junior, M. C. (2011). Preparo de cólon para realização de colonoscopia: estudo prospectivo randomizado comparativo entre solução de polietilenoglicol baixo volume mais bisacodil versus solução de manitol mais bisacodil. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5147/tde-02122011-110656/ ;

Chicago Manual of Style (16^th Edition):

Vieira Junior, Manoel Carlos. “Preparo de cólon para realização de colonoscopia: estudo prospectivo randomizado comparativo entre solução de polietilenoglicol baixo volume mais bisacodil versus solução de manitol mais bisacodil.” 2011. Masters Thesis, University of São Paulo. Accessed February 28, 2021. http://www.teses.usp.br/teses/disponiveis/5/5147/tde-02122011-110656/ ;.

MLA Handbook (7^th Edition):

Vieira Junior, Manoel Carlos. “Preparo de cólon para realização de colonoscopia: estudo prospectivo randomizado comparativo entre solução de polietilenoglicol baixo volume mais bisacodil versus solução de manitol mais bisacodil.” 2011. Web. 28 Feb 2021.

Vancouver:

Vieira Junior MC. Preparo de cólon para realização de colonoscopia: estudo prospectivo randomizado comparativo entre solução de polietilenoglicol baixo volume mais bisacodil versus solução de manitol mais bisacodil. [Internet] [Masters thesis]. University of São Paulo; 2011. [cited 2021 Feb 28]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5147/tde-02122011-110656/ ;.

Council of Science Editors:

Vieira Junior MC. Preparo de cólon para realização de colonoscopia: estudo prospectivo randomizado comparativo entre solução de polietilenoglicol baixo volume mais bisacodil versus solução de manitol mais bisacodil. [Masters Thesis]. University of São Paulo; 2011. Available from: http://www.teses.usp.br/teses/disponiveis/5/5147/tde-02122011-110656/ ;

12. Μπαμπούρη, Ιωάννα. Φαρμακοδυναμική μελέτη συνθετικού αντικαρκινικού πεπτιδίου και βελτίωση της in vivo σταθερότητας με σύνδεση με πολυαιθυλενογλυκόλη.

Degree: 2013, University of Patras

URL: http://hdl.handle.net/10889/6604

►

Η συσχέτιση της πρωτεΐνης PSP94 με τον καρκίνο του προστάτη είναι γνωστή, καθώς μειωμένα επίπεδα της PSP94 σχετίζονται με τα προχωρημένα, μεταστατικά στάδια καρκίνου του… (more)

▼

Η συσχέτιση της πρωτεΐνης PSP94 με τον καρκίνο του προστάτη είναι γνωστή, καθώς μειωμένα επίπεδα της PSP94 σχετίζονται με τα προχωρημένα, μεταστατικά στάδια καρκίνου του προστάτη, και υποτίθεται ότι η πλήρης έκφρασή της συμβάλλει στην αναχαίτιση της καρκινικής ανάπτυξης. Το PCK3145, ένα συνθετικό δεκαπενταμερές πεπτίδιο, του οποίου η αλληλουχία αμινοξέων είναι ταυτόσημο με την αλληλουχία των αμινοξέων 31 έως 45 της PSP94, επιλέχτηκε μεταξύ 12 διαφορετικών πεπτιδίων που προέκυψαν από την PSP94 καθώς εδείχθη οτι ανακεφαλαιώνει in vitro και in vivo τις λειτουργίες και ιδιότητες της PSP94, και άρα είναι ένα μόριο που μπορεί να χρησιμοποιηθεί στην καταστολή της ανάπτυξης του καρκίνου του προστάτη. Ωστόσο, φαρμακοκινητικές μελέτες σε ζώα και ασθενείς με καρκίνο του προστάτη, κατέδειξαν ταχεία κάθαρση και μικρό χρόνο ημιζωής. Προκειμένου να ενισχυθεί το φαρμακοκινητικό προφίλ του πεπτιδίου PCK3145 και ως εκ τούτου να βελτιωθεί η φαρμακοδυναμική του, υπέστη χημική τροποποίηση με προσθήκη πολυαιθυλενικής γλυκόλης (PEG). Η πειραματική εργασία παρουσιάζει τα αποτελέσματα μιας συστηματικής μελέτης σχετικά με την επίδραση της πεγκυλίωσης στο PCK3145 συγκρίνοντας την πρωτεολυτική σταθερότητα και βιολογική δράση δύο πεγκυλιωμένων συζευγμάτων του με την καθαρή μορφή του. Για την ποσοτικοποίηση και για τα πειράματα σταθερότητας χρησιμοποιήθηκε ένα σύστημα υγρής χρωματογραφίας υψηλής απόδοσης HPLC αποτελούμενο από μια αντλία Ultimate (Dionex). Ο χρωματογραφικός διαχωρισμός επιτεύχθηκε με μια στήλη ανάστροφης φάσης C18. Επετεύχθη για πρώτη φορά η ανάπτυξη αναλυτικής μεθοδολογίας HPLC για τον προσδιορισμό των πεγκυλιωμένων αναλόγων με υψηλού βαθμού γραμμικότητα, ειδικότητα, επαναληψιμότητα και αναπαραγωγιμότητα. Η πρωτεολυτική σταθερότητα των συζευγμάτων PEG σε ανθρώπινο πλάσμα προσδιορίστηκε με χρήση υγρής χρωματογραφίας HPLC και αποκαλύφθηκε μείωση του ποσοστού αποδόμησης και ενίσχυσξ της σταθερότητας του πεπτιδικών μορίων σε ανθρώπινο πλάσμα. H μελέτη επιβίωσης της κυτταρικής σειράς καρκίνου του προστάτη PC3 μετά την προσθήκη των πεπτιδικών μορίων υπό μελέτη υπολογίστηκε με τις μεθόδους ΜΤΤ και Trypan blue. 50% αναστολή της κυτταρικής αύξησης/μεταβολισμού επετεύχθη με τις συγκεντρώσεις των 10μg/ml και για τα τρία πεπτίδια. Ωστόσο, τα πεγκυλιωμένα ανάλογα επέφεραν ισχυρότερη ανασταλτική επίδραση στην κυτταρική αύξηση σε μικρότερες δόσεις. Παρόμοια ενθαρρυντικά αποτελέσματα υπήρξαν και για την δράση των μορίων στη καρκινική σειρά του μαστού MCF-7. Τα αποτελέσματα της μελέτης συνοψίζονται στην ικανότητα της πεγκυλίωσης να βελτιώνει τη σταθερότητα του PCK3145 και έτσι να ενισχύει τη βιολογική του δράση. Μελλοντικά πειράματα θα αποσαφηνίσουν περισσότερο τόσο την δράση των μορίων σε καρκινικές σειρές πέραν του προστάτη αλλά και την φαρμακοκινητική συμπεριφορά των πεπτιδικών αναλόγων μέσω πειραμάτων in vivo της βιοκατανομής και μεταβολισμού τους.

PSP94, protein is known to have specific implications with prostate cancer where a down-regulation of PSP94 levels is associated with advanced metastatic prostate cancer and it is…

Advisors/Committee Members: Σιβολαπένκο, Γρηγόρης, Mpampouri, Ioanna, Σιβολαπένκο, Γρηγόρης, Σπυρούλιας, Γεώργιος, Τοπούζης, Σταύρος.

Subjects/Keywords: Πολυαιθυλενική γλυκόλη; Σταθερότητα πεπτιδίου; 615.761; Polyethylene glycol (PEG); Peptide stability; PCK3145

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Μπαμπούρη, �. (2013). Φαρμακοδυναμική μελέτη συνθετικού αντικαρκινικού πεπτιδίου και βελτίωση της in vivo σταθερότητας με σύνδεση με πολυαιθυλενογλυκόλη. (Masters Thesis). University of Patras. Retrieved from http://hdl.handle.net/10889/6604

Chicago Manual of Style (16^th Edition):

Μπαμπούρη, Ιωάννα. “Φαρμακοδυναμική μελέτη συνθετικού αντικαρκινικού πεπτιδίου και βελτίωση της in vivo σταθερότητας με σύνδεση με πολυαιθυλενογλυκόλη.” 2013. Masters Thesis, University of Patras. Accessed February 28, 2021. http://hdl.handle.net/10889/6604.

MLA Handbook (7^th Edition):

Μπαμπούρη, Ιωάννα. “Φαρμακοδυναμική μελέτη συνθετικού αντικαρκινικού πεπτιδίου και βελτίωση της in vivo σταθερότητας με σύνδεση με πολυαιθυλενογλυκόλη.” 2013. Web. 28 Feb 2021.

Vancouver:

Μπαμπούρη �. Φαρμακοδυναμική μελέτη συνθετικού αντικαρκινικού πεπτιδίου και βελτίωση της in vivo σταθερότητας με σύνδεση με πολυαιθυλενογλυκόλη. [Internet] [Masters thesis]. University of Patras; 2013. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10889/6604.

Council of Science Editors:

Μπαμπούρη �. Φαρμακοδυναμική μελέτη συνθετικού αντικαρκινικού πεπτιδίου και βελτίωση της in vivo σταθερότητας με σύνδεση με πολυαιθυλενογλυκόλη. [Masters Thesis]. University of Patras; 2013. Available from: http://hdl.handle.net/10889/6604

Universidade Federal de Viçosa

13. Cláudio Luís Nina Gomes. Efeitos do polietilenoglicol (PEG 3350) e soluções poliônicas administradas por via enteral e intravenosa em equinos.

Degree: 2010, Universidade Federal de Viçosa

URL: http://www.tede.ufv.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=3348

► Sob um delineamento cross-over, foram mensurados os parâmetros clínicos, o hemograma, o exame bioquímico, a hemogasometria, os ânions gap, a diferença de íons fortes, o… (more)

▼ Sob um delineamento cross-over, foram mensurados os parâmetros clínicos, o hemograma, o exame bioquímico, a hemogasometria, os ânions gap, a diferença de íons fortes, o exame de urina, a umidade e o aspecto das fezes, a frequência de defecações, a taxa de passagem ceco-cólica (TxPcc) e o tempo médio de retenção ceco-cólico (TMRcc) da digesta em cinco fêmeas equinas hígidas, que receberam cinco tratamentos diferentes: PEG polietilenoglicol 3350 (1,5 g kg-1, diluído em 5 L de água, fornecido em bolus, via sonda nasogástrica, dose única): PEG+RL polietileglicol 3350 (1,5 g kg-1, diluído em 5 L de água, fornecido em bolus, via sonda nasogástrica, dose única), associado ao Ringer lactato (15 mL kg-1 h-1, IV, durante 12 horas em fluxo contínuo); SIPE solução isotônica poliônica enteral: 6 g de NaCl; 0,5 g de kCl; de 1 g gluconato de Ca; 0,3 g de pidolato de Mg; 5 g de maltodextrina; q.s.p. 1.000 mL (15 mL kg-1 h-1, durante 12 horas em fluxo contínuo, via sonda nasogástrica); SIPE+RL solução isotônica poliônica enteral utilizada no tratamento SIPE (7,5 mL kg-1 h-1 durante 12 horas em fluxo contínuo, via sonda nasogástrica) associada ao Ringer lactato (7,5 mL kg-1 h-1, IV, durante 12 horas em fluxo contínuo); NaCl solução de cloreto de sódio a 0,9%, na dose de 15 mL kg-1 h-1, IV, durante 12 horas em fluxo contínuo. A avaliação clínica, o hemograma, a hemogasometria, o exame bioquímico, o exame de urina e a umidade das fezes foram realizados nos seguintes tempos: imediatamente antes do início dos tratamentos (T0h), às seis horas de tratamento (T6h), ao final do tratamento (T12h), com 24 (T24h) e 48 horas (T48h) após o T0h. A frequência de defecações e o aspecto das fezes foram avaliados em oito intervalos: 0 a 6, 6 a 12, 12 a 18, 18 a 24, 24 a 30, 30 a 36, 36 a 42 e 42 a 48 horas, enquanto a TxPcc e o TMRcc foram determinados como: 0, 3, 6, 12, 18, 24, 30, 36, 48, 72, 96, 120 e 144 horas. O PEG não alterou os parâmetros clínicos e laboratoriais, ocasionou apenas fezes com consistência semipastosa e não aumentou a motilidade intestinal; o PEG+RL diminuiu discretamente o cálcio ionizado, o fósforo, o bicarbonato e o cBase no sangue, mas não alterou o pH e exerceu efeito laxativo; o SIPE causou discreto aumento na taxa de cloreto, reduziu o cortisol sérico, o pH, o cHCO3 -, o cBase, o pCO2, o tCO2 e a DIF do sangue venoso, e foi o tratamento que menos aumentou o cortisol sérico e o mais eficiente em aumentar a umidade das fezes e o amolecimento destas, além de aumentar o peristaltismo do cólon maior e a TxPcc da digesta, consequentemente o trânsito intestinal. Também foi o tratamento que apresentou efeito laxativo mais intenso. O SIPE+RL provocou discreta diminuição no pH, cHCO3 -, cBase, pCO2, e tCO2 venosos, aumentou o Na+ sérico, o ânion Gap e a DIF e demonstrou efeito laxativo em tornar as fezes pastosas. O NaCl ocasionou acidose metabólica hiperclorêmica e acidúria e também o aparecimento de fezes pastosas. Concluiu-se que o polietilenoglicol (PEG 3350) é pouco eficiente em amolecer as fezes, evidenciando discreto efeito… Advisors/Committee Members: José Domingos Guimarães, Maria Verônica de Souza, José Dantas Ribeiro Filho, Tânia Toledo de Oliveira, Geraldo Eleno Silveira Alves, Roberto Calderon Gonçalves.

Subjects/Keywords: Fluidoterapia; CLINICA VETERINARIA; Polietilenoglicol; Equinos; Fluid; Polyethylene glycol; Equine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gomes, C. L. N. (2010). Efeitos do polietilenoglicol (PEG 3350) e soluções poliônicas administradas por via enteral e intravenosa em equinos. (Thesis). Universidade Federal de Viçosa. Retrieved from http://www.tede.ufv.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=3348

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gomes, Cláudio Luís Nina. “Efeitos do polietilenoglicol (PEG 3350) e soluções poliônicas administradas por via enteral e intravenosa em equinos.” 2010. Thesis, Universidade Federal de Viçosa. Accessed February 28, 2021. http://www.tede.ufv.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=3348.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gomes, Cláudio Luís Nina. “Efeitos do polietilenoglicol (PEG 3350) e soluções poliônicas administradas por via enteral e intravenosa em equinos.” 2010. Web. 28 Feb 2021.

Vancouver:

Gomes CLN. Efeitos do polietilenoglicol (PEG 3350) e soluções poliônicas administradas por via enteral e intravenosa em equinos. [Internet] [Thesis]. Universidade Federal de Viçosa; 2010. [cited 2021 Feb 28]. Available from: http://www.tede.ufv.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=3348.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gomes CLN. Efeitos do polietilenoglicol (PEG 3350) e soluções poliônicas administradas por via enteral e intravenosa em equinos. [Thesis]. Universidade Federal de Viçosa; 2010. Available from: http://www.tede.ufv.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=3348

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

14. Liu, Yifan. High-Performance Reverse Osmosis Membrane Enabled by Nanofillers and Surface Modification.

Degree: MS, Materials Science and Engineering, 2016, Texas A&M University

URL: http://hdl.handle.net/1969.1/187327

► With the rising demand for sustainably producing fresh water from saline sources, many researchers have been attracted to develop new reverse osmosis (RO) membranes with… (more)

Subjects/Keywords: Desalination; graphene oxide; zeolite; Polyethylene glycol; mult-structure membrane.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Liu, Y. (2016). High-Performance Reverse Osmosis Membrane Enabled by Nanofillers and Surface Modification. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/187327

Chicago Manual of Style (16^th Edition):

Liu, Yifan. “High-Performance Reverse Osmosis Membrane Enabled by Nanofillers and Surface Modification.” 2016. Masters Thesis, Texas A&M University. Accessed February 28, 2021. http://hdl.handle.net/1969.1/187327.

MLA Handbook (7^th Edition):

Liu, Yifan. “High-Performance Reverse Osmosis Membrane Enabled by Nanofillers and Surface Modification.” 2016. Web. 28 Feb 2021.

Vancouver:

Liu Y. High-Performance Reverse Osmosis Membrane Enabled by Nanofillers and Surface Modification. [Internet] [Masters thesis]. Texas A&M University; 2016. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1969.1/187327.

Council of Science Editors:

Liu Y. High-Performance Reverse Osmosis Membrane Enabled by Nanofillers and Surface Modification. [Masters Thesis]. Texas A&M University; 2016. Available from: http://hdl.handle.net/1969.1/187327

Virginia Commonwealth University

15. Dancho, David M. Analysis of Polyethylene Glycol in the α-Hemolysin Nanopore.

Degree: MS, Physics and Applied Physics, 2013, Virginia Commonwealth University

URL: https://doi.org/10.25772/ZYP0-E752 ; https://scholarscompass.vcu.edu/etd/483

► Nanopores have been shown to be a useful analytical tool for single molecule detection. They have been used to study the composition of DNA… (more)

Subjects/Keywords: α-Hemolysin; nanopore; Polyethylene Glycol; Physical Sciences and Mathematics; Physics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dancho, D. M. (2013). Analysis of Polyethylene Glycol in the α-Hemolysin Nanopore. (Thesis). Virginia Commonwealth University. Retrieved from https://doi.org/10.25772/ZYP0-E752 ; https://scholarscompass.vcu.edu/etd/483

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dancho, David M. “Analysis of Polyethylene Glycol in the α-Hemolysin Nanopore.” 2013. Thesis, Virginia Commonwealth University. Accessed February 28, 2021. https://doi.org/10.25772/ZYP0-E752 ; https://scholarscompass.vcu.edu/etd/483.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dancho, David M. “Analysis of Polyethylene Glycol in the α-Hemolysin Nanopore.” 2013. Web. 28 Feb 2021.

Vancouver:

Dancho DM. Analysis of Polyethylene Glycol in the α-Hemolysin Nanopore. [Internet] [Thesis]. Virginia Commonwealth University; 2013. [cited 2021 Feb 28]. Available from: https://doi.org/10.25772/ZYP0-E752 ; https://scholarscompass.vcu.edu/etd/483.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dancho DM. Analysis of Polyethylene Glycol in the α-Hemolysin Nanopore. [Thesis]. Virginia Commonwealth University; 2013. Available from: https://doi.org/10.25772/ZYP0-E752 ; https://scholarscompass.vcu.edu/etd/483

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Queensland University of Technology

16. Fernandes, Wren Austin. Synthesis of an erodible biomimetic hydrogel for drug delivery using native chemical ligation.

Degree: 2012, Queensland University of Technology

URL: https://eprints.qut.edu.au/59502/

► Hydrogels are hydrophilic, three dimensional polymers that imbibe large quantities of water while remaining insoluble in aqueous solutions due to chemical or physical cross-linking. The… (more)

▼ Hydrogels are hydrophilic, three dimensional polymers that imbibe large quantities of water while remaining insoluble in aqueous solutions due to chemical or physical cross-linking. The polymers swell in water or biological fluids, immobilizing the bioactive agent, leading to drug release in a well-defined specific manner. Thus the hydrogels’ elastic properties, swellability and biocompatibility make them excellent formulations for drug delivery. Currently, many drug potencies and therapeutic effects are limited or otherwise reduced because of the partial degradation that occurs before the administered drug reaches the desired site of action. On the other hand, sustained release medications release drugs continually, rather than providing relief of symptoms and protection solely when necessary. In fact, it would be much better if drugs could be administered in a manner that precisely matches physiological needs at desired times and at the desired site (site specific targeting). There is therefore an unmet need to develop controlled drug delivery systems especially for delivery of peptide and protein bound drugs. The purpose of this project is to produce hydrogels for structural drug delivery and time-dependent sustained release of drugs (bioactive agents). We use an innovative polymerisation strategy based on native chemical ligation (NCL) to covalently cross-link polymers to form hydrogels. When mixed in aqueous solution, four armed (polyethylene glycol) amine (PEG-4A) end functionalised with thioester and four branched Nterminal cysteine peptide dendrimers spontaneously conjugated to produce biomimetic hydrogels. These hydrogels showed superior resistance to shear stress compared to an equivalent PEG macromonomer system and were shown to be proteolytically degradable with concomitant release of a model payload molecule. This is the first report of a peptide dendrimers/PEG macromonomer approach to hydrogel production and opens up the prospect of facile hydrogel synthesis together with tailored payload release.

Subjects/Keywords: hydrogel; biomimetic; polyethylene glycol; native chemical ligation; controlled drug delivery

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APA (6^th Edition):

Fernandes, W. A. (2012). Synthesis of an erodible biomimetic hydrogel for drug delivery using native chemical ligation. (Thesis). Queensland University of Technology. Retrieved from https://eprints.qut.edu.au/59502/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fernandes, Wren Austin. “Synthesis of an erodible biomimetic hydrogel for drug delivery using native chemical ligation.” 2012. Thesis, Queensland University of Technology. Accessed February 28, 2021. https://eprints.qut.edu.au/59502/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fernandes, Wren Austin. “Synthesis of an erodible biomimetic hydrogel for drug delivery using native chemical ligation.” 2012. Web. 28 Feb 2021.

Vancouver:

Fernandes WA. Synthesis of an erodible biomimetic hydrogel for drug delivery using native chemical ligation. [Internet] [Thesis]. Queensland University of Technology; 2012. [cited 2021 Feb 28]. Available from: https://eprints.qut.edu.au/59502/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fernandes WA. Synthesis of an erodible biomimetic hydrogel for drug delivery using native chemical ligation. [Thesis]. Queensland University of Technology; 2012. Available from: https://eprints.qut.edu.au/59502/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Delaware

17. McGann, Christopher Leland. Resilin-like polypeptide-poly(ethylene gylcol) hybrid hydrogels for mechanically-demanding tissue engineering applications.

Degree: PhD, University of Delaware, Department of Materials Science and Engineering, 2015, University of Delaware

URL: http://udspace.udel.edu/handle/19716/17169

► Technological progress in the life sciences and engineering has combined with important insights in the fields of biology and material science to make possible the… (more)

▼ Technological progress in the life sciences and engineering has combined with important insights in the fields of biology and material science to make possible the development of biological substitutes which aim to restore function to damaged tissue. Numerous biomimetic hydrogels have been developed with the purpose of harnessing the regenerative capacity of cells and tissue through the rational deployment of biological signals. Aided by recombinant DNA technology and protein engineering methods, a new class of hydrogel precursor, the biosynthetic protein polymer, has demonstrated great promise towards the development of highly functional tissue engineering materials. In particular, protein polymers based upon resilin, a natural protein elastomer, have demonstrated outstanding mechanical properties that would have great value in soft tissue applications. This dissertation introduces hybrid hydrogels composed of recombinant resilin-like polypeptides (RLPs) cross-linked with multi-arm PEG macromers. Two different chemical strategies were employed to form RLP-PEG hydrogels: one utilized a Michael-type addition reaction between the thiols of cysteine residues present within the RLP and vinyl sulfone moieties functionalized on a multi-arm PEG macromer; the second system cross-links a norbornene-functionalized RLP with a thiol-functionalized multi-arm PEG macromer via a photoinitiated thiol-ene step polymerization. Oscillatory rheology and tensile testing confirmed the formation of elastic, resilient hydrogels in the RLP-PEG system cross-linked via Michael-type addition. These hydrogels supported the encapsulation and culture of both human aortic adventitial fibroblasts and human mesenchymal stem cells. Additionally, these RLP-PEG hydrogels exhibited phase separation behavior during cross-linking that led to the formation of a heterogeneous microstructure. Degradation could be triggered through incubation with matrix metalloproteinase. Photocross-linking was conferred to RLPs through the successful conjugation of norbornene acid to the protein. Oscillatory rheology characterized the gelation and subsequent mechanical properties of the photoreactive RLP-PEG hydrogels while the cytocompatibility was confirmed via the successful encapsulation and culture of human mesenchymal stem cells. Both strategies demonstrate the utility of hybrid materials that combine biosynthetic proteins with synthetic polymers. As resilient and cytocompatible materials, RLP-PEG hybrid hydrogels offer an exciting strategy towards the development of biomimetic tissue engineering scaffolds for mechanically-demanding applications. Advisors/Committee Members: Kiick, Kristi L..

Subjects/Keywords: Colloids.; Polyethylene glycol.; Resilin.; Tissue engineering.; Fibroblasts.; Mesenchymal stem cells.

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APA (6^th Edition):

McGann, C. L. (2015). Resilin-like polypeptide-poly(ethylene gylcol) hybrid hydrogels for mechanically-demanding tissue engineering applications. (Doctoral Dissertation). University of Delaware. Retrieved from http://udspace.udel.edu/handle/19716/17169

Chicago Manual of Style (16^th Edition):

McGann, Christopher Leland. “Resilin-like polypeptide-poly(ethylene gylcol) hybrid hydrogels for mechanically-demanding tissue engineering applications.” 2015. Doctoral Dissertation, University of Delaware. Accessed February 28, 2021. http://udspace.udel.edu/handle/19716/17169.

MLA Handbook (7^th Edition):

McGann, Christopher Leland. “Resilin-like polypeptide-poly(ethylene gylcol) hybrid hydrogels for mechanically-demanding tissue engineering applications.” 2015. Web. 28 Feb 2021.

Vancouver:

McGann CL. Resilin-like polypeptide-poly(ethylene gylcol) hybrid hydrogels for mechanically-demanding tissue engineering applications. [Internet] [Doctoral dissertation]. University of Delaware; 2015. [cited 2021 Feb 28]. Available from: http://udspace.udel.edu/handle/19716/17169.

Council of Science Editors:

McGann CL. Resilin-like polypeptide-poly(ethylene gylcol) hybrid hydrogels for mechanically-demanding tissue engineering applications. [Doctoral Dissertation]. University of Delaware; 2015. Available from: http://udspace.udel.edu/handle/19716/17169

Colorado State University

18. McLaughlin, Molly C. Environmental fate of hydraulic fracturing fluid additives after spillage on agricultural topsoil.

Degree: MS(M.S.), Civil and Environmental Engineering, 2016, Colorado State University

URL: http://hdl.handle.net/10217/173561

► Inadvertent releases of hydraulic fracturing fluid may occur at many different stages, with surface spills being the most commonly reported cause of contamination. Hydraulic fracturing… (more)

▼ Inadvertent releases of hydraulic fracturing fluid may occur at many different stages, with surface spills being the most commonly reported cause of contamination. Hydraulic fracturing (HF) frequently occurs on agricultural land, where surface spills have the potential to impact soil, groundwater and surface water quality. However, the extent of sorption, transformation, and interactions among the numerous organic HF fluid and oil & gas wastewater constituents upon environmental release is hardly known. Thus, this study aims to advance our current understanding of processes that control the environmental fate and toxicity of commonly used hydraulic fracturing chemicals with a specific focus on co-contaminant effects. Hydraulic fracturing fluid releases were simulated using aerobic batch studies conducted with a topsoil collected from Weld County, Colorado, an area where reservoirs are frequently stimulated. Each batch reactor contained varying combinations of the biocide glutaraldehyde (GA), polyethylene glycol (PEG) surfactants, and a polyacrylamide (PAM)-based friction reducer, three widely used hydraulic fracturing fluid components. Furthermore, the presence of salt was investigated in the experiments, often present at high concentration in produced water from hydraulic fracturing operations. Results showed that aqueous GA concentrations decreased by as much as 40% in the first three days of the experiment as a result of sorption to soil. Complete biodegradation of this biocide occurred in all reactors in 33 to 57 days, with the slowest removal occurring in the reactor containing salt. The fastest removal of GA was observed in the reactors containing PAM friction reducer, where degradation rates increased by 50% as compared to reactors without PAM. This increase in removal is attributed to the cross-linking reaction between GA and primary amine functional groups in the friction reducer. In the absence of GA and salt, PEG surfactants were completely biodegraded in agricultural topsoil within 42 to 71 days. Their transformation was impeded, however, in the presence of the biocide GA, and completely inhibited in the presence of 30 g/L sodium chloride, a concentration in the typical range for oil and gas wastewater. No aqueous removal of PAM was observed over a period of six months. However, adenosine triphosphate (ATP) concentrations were consistently higher in reactors containing PAM friction reducer, suggesting this additive supplied an easily accessible source of nitrogen to the microbial soil community. The findings of this study highlight the necessity to consider co-contaminant effects when we evaluate the risk of frac fluid additives and oil and gas wastewater constituents in agricultural soils in order to fully understand their human health impacts, likelihood for crop uptake, and potential for groundwater contamination. Advisors/Committee Members: Blotevogel, Jens (advisor), Borch, Thomas (advisor), DiVerdi, Joseph (committee member).

Subjects/Keywords: friction reducer; hydraulic fracturing; surfactant; glutaraldehyde; biocide; polyethylene glycol

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APA (6^th Edition):

McLaughlin, M. C. (2016). Environmental fate of hydraulic fracturing fluid additives after spillage on agricultural topsoil. (Masters Thesis). Colorado State University. Retrieved from http://hdl.handle.net/10217/173561

Chicago Manual of Style (16^th Edition):

McLaughlin, Molly C. “Environmental fate of hydraulic fracturing fluid additives after spillage on agricultural topsoil.” 2016. Masters Thesis, Colorado State University. Accessed February 28, 2021. http://hdl.handle.net/10217/173561.

MLA Handbook (7^th Edition):

McLaughlin, Molly C. “Environmental fate of hydraulic fracturing fluid additives after spillage on agricultural topsoil.” 2016. Web. 28 Feb 2021.

Vancouver:

McLaughlin MC. Environmental fate of hydraulic fracturing fluid additives after spillage on agricultural topsoil. [Internet] [Masters thesis]. Colorado State University; 2016. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10217/173561.

Council of Science Editors:

McLaughlin MC. Environmental fate of hydraulic fracturing fluid additives after spillage on agricultural topsoil. [Masters Thesis]. Colorado State University; 2016. Available from: http://hdl.handle.net/10217/173561

King's College London (University of London)

19. Chatham, Sarah Marianna. Characterisation of molten filled hard gelatin capsules.

Degree: PhD, 1985, King's College London (University of London)

URL: https://kclpure.kcl.ac.uk/portal/en/theses/characterisation-of-molten-filled-hard-gelatin-capsules(5b2e73bf-b02c-4ecc-b00a-146fd90ec814).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261912

Subjects/Keywords: 615.1; Polyethylene glycol 4000

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APA (6^th Edition):

Chatham, S. M. (1985). Characterisation of molten filled hard gelatin capsules. (Doctoral Dissertation). King's College London (University of London). Retrieved from https://kclpure.kcl.ac.uk/portal/en/theses/characterisation-of-molten-filled-hard-gelatin-capsules(5b2e73bf-b02c-4ecc-b00a-146fd90ec814).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261912

Chicago Manual of Style (16^th Edition):

Chatham, Sarah Marianna. “Characterisation of molten filled hard gelatin capsules.” 1985. Doctoral Dissertation, King's College London (University of London). Accessed February 28, 2021. https://kclpure.kcl.ac.uk/portal/en/theses/characterisation-of-molten-filled-hard-gelatin-capsules(5b2e73bf-b02c-4ecc-b00a-146fd90ec814).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261912.

MLA Handbook (7^th Edition):

Chatham, Sarah Marianna. “Characterisation of molten filled hard gelatin capsules.” 1985. Web. 28 Feb 2021.

Vancouver:

Chatham SM. Characterisation of molten filled hard gelatin capsules. [Internet] [Doctoral dissertation]. King's College London (University of London); 1985. [cited 2021 Feb 28]. Available from: https://kclpure.kcl.ac.uk/portal/en/theses/characterisation-of-molten-filled-hard-gelatin-capsules(5b2e73bf-b02c-4ecc-b00a-146fd90ec814).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261912.

Council of Science Editors:

Chatham SM. Characterisation of molten filled hard gelatin capsules. [Doctoral Dissertation]. King's College London (University of London); 1985. Available from: https://kclpure.kcl.ac.uk/portal/en/theses/characterisation-of-molten-filled-hard-gelatin-capsules(5b2e73bf-b02c-4ecc-b00a-146fd90ec814).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261912

Hong Kong University of Science and Technology

20. Chen, Yilong. Amphiphilic luminogenic materials with aggregation-induced emission features : synthesis, properties and biological applications.

Degree: 2014, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-71661 ; https://doi.org/10.14711/thesis-b1334244 ; http://repository.ust.hk/ir/bitstream/1783.1-71661/1/th_redirect.html

► Fluorescent bioprobes have been widely utilized in academic research and clinical practice for their unique advantages. However, the scope of the bio-applications of many conventional… (more)

▼ Fluorescent bioprobes have been widely utilized in academic research and clinical practice for their unique advantages. However, the scope of the bio-applications of many conventional organic fluorophores is impeded from the self-quenching problem at high solution concentration and in the aggregated state, or the so called aggregation-cause quenching (ACQ) effect. Evidently, ACQ is a harmful photophysical effect in terms of light emission and practical applications. Recently, another emerging photophysical phenomenon associated with chromophore aggregation is aggregation-induced emission (AIE), which is opposite and complementary to the ACQ effect. Archetypal AIEgens are constructed from aromatic phenyl rings, which are hydrophobic in nature. Amphphilic AIEgens, on the contrary, are seldom designed and prepared. In this work, several amphiphilic AIEgens are synthesized containing non-ionic, cationic and anionic units. They are soluble in water and form micelles above the critical micelle concentration (CMC). Below the CMC, the AIEgens exist as isolated molecules and emit no light. They, however, emit intensely at above CMC due to the formation of micelle or nanoaggregate. The amphiphilic AIEgens are generally non-toxic and biocompatible. Nonionic and amphiphilic polyethene glycol-decorated tetraphenylethenes are synthesized by azide-alkyne cycloaddition. Their AIE property, micellation, thermosensitive behaviors and use as fluorescent visualizer for intracellular imaging and tracking are explored. It is found that the AIEgen could tracing the cell growth as long as 5 generations. Cationic and amphiphilic tetraphenylethene-based pyridinium salts with AIE characteristics for selective cell membrane staining in HeLa cells and bacteria are successfully developed. Owning to the inherent photostability of the AIEgens, the new molecules are excellent AIE cell membrane stains. Interestingly, the molecules can generate reactive oxygen species (ROS) under room light irradiation. The first discovery of ROS generation on AIEgens enables a visible observation of cell necrosis and phototherapeutic effect under mild conditions. This makes them potential as selective phototherapy candidate drugs and it is worthy for further exploration of their phototherapeutic effect in animals. A novel dual-modal MRI contrasting agent (TPE-2Gd) containing hydrophobic tetraphenylethene unit and hydrophilic diethylenetriaminepentaacetic acid-gadolinium complex was successfully synthesized for both magnetic and fluorescent imaging. Results show that TPE-2Gd is an ideal MRI contrasting agent with long circulation lifetime for diagnosis and short circulation lifetime enough for body clearance.

Subjects/Keywords: Luminescence ; Fluorescence ; Fluorescent probes ; Polyethylene glycol ; Aggregation (Chemistry)

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APA (6^th Edition):

Chen, Y. (2014). Amphiphilic luminogenic materials with aggregation-induced emission features : synthesis, properties and biological applications. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-71661 ; https://doi.org/10.14711/thesis-b1334244 ; http://repository.ust.hk/ir/bitstream/1783.1-71661/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chen, Yilong. “Amphiphilic luminogenic materials with aggregation-induced emission features : synthesis, properties and biological applications.” 2014. Thesis, Hong Kong University of Science and Technology. Accessed February 28, 2021. http://repository.ust.hk/ir/Record/1783.1-71661 ; https://doi.org/10.14711/thesis-b1334244 ; http://repository.ust.hk/ir/bitstream/1783.1-71661/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chen, Yilong. “Amphiphilic luminogenic materials with aggregation-induced emission features : synthesis, properties and biological applications.” 2014. Web. 28 Feb 2021.

Vancouver:

Chen Y. Amphiphilic luminogenic materials with aggregation-induced emission features : synthesis, properties and biological applications. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2014. [cited 2021 Feb 28]. Available from: http://repository.ust.hk/ir/Record/1783.1-71661 ; https://doi.org/10.14711/thesis-b1334244 ; http://repository.ust.hk/ir/bitstream/1783.1-71661/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chen Y. Amphiphilic luminogenic materials with aggregation-induced emission features : synthesis, properties and biological applications. [Thesis]. Hong Kong University of Science and Technology; 2014. Available from: http://repository.ust.hk/ir/Record/1783.1-71661 ; https://doi.org/10.14711/thesis-b1334244 ; http://repository.ust.hk/ir/bitstream/1783.1-71661/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Hong Kong University of Science and Technology

21. Hossain, Naushad. Formation of calcium phosphate nanoparticles with DNA and PEGylated octaarginine.

Degree: 2015, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-80140 ; https://doi.org/10.14711/thesis-b1552101 ; http://repository.ust.hk/ir/bitstream/1783.1-80140/1/th_redirect.html

► Calcium phosphate (CaP) nanoparticles (NPs), due to its biocompatibility, has been extensively studied as one kind of gene delivery vectors for cancer therapy. However, its… (more)

Subjects/Keywords: Calcium phosphate ; Polyethylene glycol ; Nanoparticles ; Cancer ; Gene therapy ; Arginine

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APA (6^th Edition):

Hossain, N. (2015). Formation of calcium phosphate nanoparticles with DNA and PEGylated octaarginine. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-80140 ; https://doi.org/10.14711/thesis-b1552101 ; http://repository.ust.hk/ir/bitstream/1783.1-80140/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hossain, Naushad. “Formation of calcium phosphate nanoparticles with DNA and PEGylated octaarginine.” 2015. Thesis, Hong Kong University of Science and Technology. Accessed February 28, 2021. http://repository.ust.hk/ir/Record/1783.1-80140 ; https://doi.org/10.14711/thesis-b1552101 ; http://repository.ust.hk/ir/bitstream/1783.1-80140/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hossain, Naushad. “Formation of calcium phosphate nanoparticles with DNA and PEGylated octaarginine.” 2015. Web. 28 Feb 2021.

Vancouver:

Hossain N. Formation of calcium phosphate nanoparticles with DNA and PEGylated octaarginine. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2015. [cited 2021 Feb 28]. Available from: http://repository.ust.hk/ir/Record/1783.1-80140 ; https://doi.org/10.14711/thesis-b1552101 ; http://repository.ust.hk/ir/bitstream/1783.1-80140/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hossain N. Formation of calcium phosphate nanoparticles with DNA and PEGylated octaarginine. [Thesis]. Hong Kong University of Science and Technology; 2015. Available from: http://repository.ust.hk/ir/Record/1783.1-80140 ; https://doi.org/10.14711/thesis-b1552101 ; http://repository.ust.hk/ir/bitstream/1783.1-80140/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rice University

22. Saik, Jennifer Elaine. Bioactive Poly(ethylene glycol)-based Hydrogels for Angiogenesis in Tissue Engineering.

Degree: PhD, Engineering, 2011, Rice University

URL: http://hdl.handle.net/1911/70422

► Because engineered tissue constructs are inherently limited by their lack of microvascularization, which is essential to provide oxygen for cell survival, this thesis presents rationally… (more)

▼ Because engineered tissue constructs are inherently limited by their lack of microvascularization, which is essential to provide oxygen for cell survival, this thesis presents rationally designed materials and cell culture techniques capable of supporting functional tubule formation and stabilization. Combining a synthetic scaffold material with cells and their cell-secreted signals instigated tubule formation throughout the scaffold. Poly(ethylene glycol) (PEG) based hydrogels, biocompatible polymers which resist protein adsorption and subsequent nonspecific cellular adhesion, were modified to induce desired cell characteristics. Human umbilical vein endothelial cells were used as a reproducible and readily available cell type. Several tubule-stabilization signals, including platelet derived growth factor-BB (PDGF-BB) and ephrinA1, were covalently immobilized via conjugation to PEG to enable prolonged bioactive signaling and controlled local delivery. All hydrogels were further tested in a mouse cornea micropocket angiogenesis assay, a naturally avascular tissue for easy imaging in a reproducible and quantifiable assay. Hydrogels containing soluble growth factors induced vessel formation in the hydrogel, and the resulting vessel morphology was modulated using different growth factor concentrations. Immobilized PDGF-BB led to tubule formation in two dimensions, three dimensions, and in the mouse cornea while immobilized ephrinA1 stimulated secretion of extracellular matrix proteins laminin and collagen IV to stabilize the newly formed tubules. Finally, a co-culture of endothelial and pericyte cells encapsulated into hydrogels formed tubules that anastomosed to the host vasculature and contained red blood cells. PEG-based hydrogels represent a promising technique to induce microvascular formation in engineered constructs, leading to stable and functional vessel formation using covalently immobilized growth factors and encapsulated cells. These materials can be used for replacement of damaged or diseased tissues as the current supply of cadaveric donations cannot meet the demand of tissues for the 110,000 people awaiting an organ in the US. Advisors/Committee Members: West, Jennifer L. (advisor).

Subjects/Keywords: Applied sciences; Polyethylene glycol; Hydrogels; Angiogenesis; Tissue engineering; Biomedical engineering

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APA (6^th Edition):

Saik, J. E. (2011). Bioactive Poly(ethylene glycol)-based Hydrogels for Angiogenesis in Tissue Engineering. (Doctoral Dissertation). Rice University. Retrieved from http://hdl.handle.net/1911/70422

Chicago Manual of Style (16^th Edition):

Saik, Jennifer Elaine. “Bioactive Poly(ethylene glycol)-based Hydrogels for Angiogenesis in Tissue Engineering.” 2011. Doctoral Dissertation, Rice University. Accessed February 28, 2021. http://hdl.handle.net/1911/70422.

MLA Handbook (7^th Edition):

Saik, Jennifer Elaine. “Bioactive Poly(ethylene glycol)-based Hydrogels for Angiogenesis in Tissue Engineering.” 2011. Web. 28 Feb 2021.

Vancouver:

Saik JE. Bioactive Poly(ethylene glycol)-based Hydrogels for Angiogenesis in Tissue Engineering. [Internet] [Doctoral dissertation]. Rice University; 2011. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1911/70422.

Council of Science Editors:

Saik JE. Bioactive Poly(ethylene glycol)-based Hydrogels for Angiogenesis in Tissue Engineering. [Doctoral Dissertation]. Rice University; 2011. Available from: http://hdl.handle.net/1911/70422

University of Waikato

23. Gnanavinthan, Thavanayagam. Producing near-net shape titanium alloy parts by metal injection moulding .

Degree: 2016, University of Waikato

URL: http://hdl.handle.net/10289/10354

► Metal injection moulding (MIM), is a metalworking process for producing complex parts from metal powders. It is often more cost effective to use MIM to… (more)

▼ Metal injection moulding (MIM), is a metalworking process for producing complex parts from metal powders. It is often more cost effective to use MIM to make small, precise componentry from expensive materials such as titanium than traditional metal processes such as casting, forming, extrusion, investment casting and machining. The four processing steps in MIM are: formulating homogenous feedstock of metal power and binders, injection moulding, removing the binder (debinding) and sintering. The binder affects feedstock rheology, allowing the required shape to be moulded. It then needs to be removed so the object can be sintered to consolidate into a near-net shaped part. As MIM has many advantages, including low wastage of material and the ability to produce intricate shapes, it is used in sophisticated applications such as biomedical instruments, in the aerospace industry, and in niche applications that use expensive materials such as titanium. The objective of this research was to identify binders and processing methods that produced easily moulded titanium-based feedstock and final products with minimal defects. This involves understanding how factors such as binder composition, powder loading, and processing method affect feedstock rheology, homogeneity, debinding and sintering, and to develop a model for investigating feedstock rheology. Feedstocks were manufactured by mixing different amounts of hydride-dehydride titanium alloy powder (HDH Ti-6Al-4V) with a three-component binder containing different amounts of polyethylene glycol (PEG), polyvinyl butyral (PVB) and stearic acid (SA). Most research on titanium powder metallurgy uses spherical, fine powders with mean diameters (d50) between 0.3 and 19 μm. This research used HDH Ti-6Al-4V, an irregular, coarse powder with a d50 of 52 μm and a d90 of 117 μm. The effect of using different types of mixers for various mixing times was evaluated by measuring mixing torque and thermal analysis. Feedstock homogeneity was evaluated by density measurements and DTA/TGA analysis, and mouldability was evaluated by rheological properties. After mixing and extrusion, binders were removed from the formed (green) part in a two-stage process involving aqueous debinding followed by thermal debinding. The part was then sintered to remove any remaining binder and to create the final product. Morphological characteristics of feedstocks, moulded, debound and sintered parts were assessed using optical and scanning electron microscopes. Polyethylene glycol, PVB and SA were used as binder components because they are inexpensive and readily available. PEG is environmentally safe, easily extractable in water and reduces feedstock viscosity. The PVB is water-insoluble and provides strength to the formed (green) parts and debound (brown or grey) parts so used as a backbone component. The SA acts as a surfactant and helps wet the powder particles. Thermal characteristics were determined with DTA/TGA and rheological analyses with a capillary rheometer. The four-stage process… Advisors/Committee Members: Swan, Janis E (advisor), Pickering, Kim L (advisor), Gabbitas, Brian (advisor).

Subjects/Keywords: Titanium; Feedstocks; Metal Injection Moulding; Polyethylene glycol; Polyvinyl butyryl; Rheology

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APA (6^th Edition):

Gnanavinthan, T. (2016). Producing near-net shape titanium alloy parts by metal injection moulding . (Doctoral Dissertation). University of Waikato. Retrieved from http://hdl.handle.net/10289/10354

Chicago Manual of Style (16^th Edition):

Gnanavinthan, Thavanayagam. “Producing near-net shape titanium alloy parts by metal injection moulding .” 2016. Doctoral Dissertation, University of Waikato. Accessed February 28, 2021. http://hdl.handle.net/10289/10354.

MLA Handbook (7^th Edition):

Gnanavinthan, Thavanayagam. “Producing near-net shape titanium alloy parts by metal injection moulding .” 2016. Web. 28 Feb 2021.

Vancouver:

Gnanavinthan T. Producing near-net shape titanium alloy parts by metal injection moulding . [Internet] [Doctoral dissertation]. University of Waikato; 2016. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10289/10354.

Council of Science Editors:

Gnanavinthan T. Producing near-net shape titanium alloy parts by metal injection moulding . [Doctoral Dissertation]. University of Waikato; 2016. Available from: http://hdl.handle.net/10289/10354

Duke University

24. Francisco, Aubrey Therese. Laminin-Functionalized Polyethylene Glycol Hydrogels for Nucleus Pulposus Regeneration .

Degree: 2013, Duke University

URL: http://hdl.handle.net/10161/8204

► Intervertebral disc (IVD) disorders and age-related degeneration are believed to contribute to low back pain. There is significant interest in cell-based strategies for regenerating… (more)

▼ Intervertebral disc (IVD) disorders and age-related degeneration are believed to contribute to low back pain. There is significant interest in cell-based strategies for regenerating the nucleus pulposus (NP) region of the disc; however, few scaffolds have been evaluated for their ability to promote or maintain an immature NP cell phenotype. Additionally, while cell delivery to the pathological IVD has significant therapeutic potential for enhancing NP regeneration, the development of injectable biomaterials that retain delivered cells, promote cell survival, and maintain or promote an NP cell phenotype in vivo remains a significant challenge. Previous studies have demonstrated NP cell - laminin interactions in the NP region of the IVD that promote cell attachment and biosynthesis. These findings suggest that incorporating laminin ligands into biomaterial scaffolds for NP tissue engineering or cell delivery to the disc may be beneficial for promoting NP cell survival and phenotype. In this dissertation, laminin-111 (LM111) functionalized poly(ethylene glycol) (PEG) hydrogels were developed and evaluated as biomaterial scaffolds for cell-based NP regeneration. Here, PEG-LM111 conjugates with functional acrylate groups for crosslinking were synthesized and characterized to allow for protein coupling to both photocrosslinkable and injectable PEG-based biomaterial scaffolds. PEG-LM111 conjugates synthesized using low ratios of PEG to LM111 were found support NP cell attachment and signaling in a manner similar to unmodified LM111. A single PEG-LM111 conjugate was conjugated to photocrosslinkable PEG-LM111 hydrogels, and studies were performed to evaluate the effects of hydrogel formulation on immature NP cell phenotype in vitro. When primary immature porcine NP cells were seeded onto PEG-LM111 hydrogels of varying stiffnesses, softer LM111 presenting hydrogels were found to promote cell clustering and increased levels of sGAG production as compared to stiffer LM111 presenting and PEG-only gels. When cells were encapsulated in 3D gels, hydrogel formulation was found to influence NP cell metabolism and expression of proposed NP phenotypic markers, with higher expression of N-cadherin and cytokeratin 8 observed for cells cultured in softer (<1 kPa) PEG-LM111 hydrogels. A novel, injectable PEG-LM111 hydrogel was developed as a biomaterial carrier for cell delivery to the IVD. PEG-LM111 conjugates were crosslinked via a Michael-type addition reaction upon the addition of PEG-octoacrylate and PEG-dithiol. Injectable PEG-LM111 hydrogel gelation time, mechanical properties, and ability to retain delivered cells in the IVD space were evaluated. Gelation occurred in approximately 20 minutes without an initiator, with dynamic shear moduli in the range of 0.9 - 1.4 kPa. Primary NP cell retention in cultured IVD explants was significantly higher over 14 days when cells were delivered within a PEG-LM111 hydrogel carrier, as compared to cells in liquid suspension. The studies presented in this… Advisors/Committee Members: Setton, Lori A (advisor).

Subjects/Keywords: Biomedical engineering; cell delivery; intervertebral disc; laminin; nucleus pulposus; polyethylene glycol

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APA (6^th Edition):

Francisco, A. T. (2013). Laminin-Functionalized Polyethylene Glycol Hydrogels for Nucleus Pulposus Regeneration . (Thesis). Duke University. Retrieved from http://hdl.handle.net/10161/8204

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Francisco, Aubrey Therese. “Laminin-Functionalized Polyethylene Glycol Hydrogels for Nucleus Pulposus Regeneration .” 2013. Thesis, Duke University. Accessed February 28, 2021. http://hdl.handle.net/10161/8204.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Francisco, Aubrey Therese. “Laminin-Functionalized Polyethylene Glycol Hydrogels for Nucleus Pulposus Regeneration .” 2013. Web. 28 Feb 2021.

Vancouver:

Francisco AT. Laminin-Functionalized Polyethylene Glycol Hydrogels for Nucleus Pulposus Regeneration . [Internet] [Thesis]. Duke University; 2013. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10161/8204.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Francisco AT. Laminin-Functionalized Polyethylene Glycol Hydrogels for Nucleus Pulposus Regeneration . [Thesis]. Duke University; 2013. Available from: http://hdl.handle.net/10161/8204

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Clemson University

25. Brown, Dakarai. SEMIFLUORINATED AROMATIC ETHER POLYMERS SEGMENTED WITH POLYETHYLENE GLYCOL (PEG).

Degree: PhD, Chemistry, 2011, Clemson University

URL: https://tigerprints.clemson.edu/all_dissertations/767

► Aromatic trifluorovinyl ether (TFVE) monomers are the precursors for perfluorocyclobutyl (PFCB) aryl ether polymers and fluoroethylene/vinylene alkyl/aryl ether (FAE) polymers. PFCB aryl ether polymers are… (more)

▼ Aromatic trifluorovinyl ether (TFVE) monomers are the precursors for perfluorocyclobutyl (PFCB) aryl ether polymers and fluoroethylene/vinylene alkyl/aryl ether (FAE) polymers. PFCB aryl ether polymers are prepared by 2π + 2π cycloaddition of aromatic TFVE monomers. FAE polymers are prepared by nucleophilic addition of dual functional aryl or alkyl alcohols to aryl TFVE monomers. PFCB aryl ether and FAE polymers are amorphous, have excellent processability, high thermal stability, optical clarity, and tunability using a variety of (co)monomers. In this dissertation several novel monomers, polymers, and blends were prepared by incorporation of polyethylene glycol (PEG) or PEG precursors. Chapter 1 contains the introduction to fluoropolymers and exceptional properties of PFCB aryl ether, FAE, and PEG polymers. Chapter 2 describes the one step synthesis of macromonomers using diethylene glycol (DEG) and a series of polyethylene glycols (PEGs). Macromonomers were homopolymerized and copolymerized using commercially available TFVE monomers and a PFCB prepolymer. All macromonomers and copolymers were characterized by 1H and 19F Nuclear magnetic resonance (NMR) and attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy. Thermal properties of all polymers were determined by thermal gravimetric analysis (TGA) and differential scanning calorimetry (DSC). Chapter 3 explores the compatibilization of PEG and a commercial polymer bis(trifluorovinyloxy) biphenyl ether (BPVE) using a copolymer from chapter 2. Reduced interfacial tension was observed by scanning electron microscope (SEM) and phase homogeneity (miscibility) was studied by DSC. After the one step synthesis of polyethylene glycol (PEG) functionalized with TFVE, a unique crystallization was discovered and is discussed in Chapter 4. DSC analysis and wide angle X-ray diffraction (WAXD) were used to characterize the crystallization of macromonomers. Chapter 5 details the preparation of a series of PEG-PFCB aryl ether segmented copolymers. Copolymers were polymerized by nucleophilic addition of polyethylene glycol (PEG) to trifluorovinyl ether (TFVE) end-groups of PFCB aryl ether oligomers. Copolymers were linked through a hydrofluoroethane (-CHFCF2-) ether bond. All polymers were well characterized as above. Tgs were studied by DSC analysis and compared to calculated values using the Fox equation. Polymerization and characterization of novel segmented semiflourinated polyaryl ether (PAEs) were discussed in chapter 6. In addition, thermal properties were explored by DSC and TGA analysis. Surface morphology of semi-crystalline polymers were studied by atomic force microscopy (AFM). Phase images show needlelike crystals. Chapter 7 outlines experimental information. Advisors/Committee Members: Smith Jr., Dennis W, Smith , Rhett, Dieter , Karl.

Subjects/Keywords: Perfluorocyclobutyl Aromatic Ether Polymers; Polyaryl ethers; Polyethylene glycol; Chemistry

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APA (6^th Edition):

Brown, D. (2011). SEMIFLUORINATED AROMATIC ETHER POLYMERS SEGMENTED WITH POLYETHYLENE GLYCOL (PEG). (Doctoral Dissertation). Clemson University. Retrieved from https://tigerprints.clemson.edu/all_dissertations/767

Chicago Manual of Style (16^th Edition):

Brown, Dakarai. “SEMIFLUORINATED AROMATIC ETHER POLYMERS SEGMENTED WITH POLYETHYLENE GLYCOL (PEG).” 2011. Doctoral Dissertation, Clemson University. Accessed February 28, 2021. https://tigerprints.clemson.edu/all_dissertations/767.

MLA Handbook (7^th Edition):

Brown, Dakarai. “SEMIFLUORINATED AROMATIC ETHER POLYMERS SEGMENTED WITH POLYETHYLENE GLYCOL (PEG).” 2011. Web. 28 Feb 2021.

Vancouver:

Brown D. SEMIFLUORINATED AROMATIC ETHER POLYMERS SEGMENTED WITH POLYETHYLENE GLYCOL (PEG). [Internet] [Doctoral dissertation]. Clemson University; 2011. [cited 2021 Feb 28]. Available from: https://tigerprints.clemson.edu/all_dissertations/767.

Council of Science Editors:

Brown D. SEMIFLUORINATED AROMATIC ETHER POLYMERS SEGMENTED WITH POLYETHYLENE GLYCOL (PEG). [Doctoral Dissertation]. Clemson University; 2011. Available from: https://tigerprints.clemson.edu/all_dissertations/767

Georgia Tech

26. Enemchukwu, Nduka Obichukwu. Bioartificial matrices to modulate epithelial morphogenesis.

Degree: PhD, Mechanical Engineering, 2013, Georgia Tech

URL: http://hdl.handle.net/1853/52938

► Acute injury of major epithelial organ systems (kidney, liver, lung, etc.) is collectively a principal cause of death worldwide. Regenerative medicine promises to meet these… (more)

▼ Acute injury of major epithelial organ systems (kidney, liver, lung, etc.) is collectively a principal cause of death worldwide. Regenerative medicine promises to meet these human health challenges by harnessing intrinsic cellular processes to repair or replace damaged tissues. Epithelial morphogenesis is a hard-wired, multicellular differentiation program that dynamically integrates microenvironmental cues to coordinate cell fate processes including adhesion, migration, proliferation, and polarization. Thus, epithelial morphogenesis is an instructive mode of tissue assembly, maintenance, and repair. Three-dimensional epithelial cell cultures in natural basement membrane (BM) extracts produce hollow, spherical cyst structures and have indicated that the BM provides the critical cell adhesion ligands to facilitate cell survival, stimulate proliferation, and promote polarization and lumen formation. However, the utility of natural BMs for detailed studies is generally limited by lot-to-lot variations, uncontrolled cell adhesive interactions, or growth factor contamination. The goal of this thesis was to engineer bioartificial extracellular matrices (ECM) that would support and modulate epithelial cyst morphogenesis. We have engineered hydrogels, based on a multi-arm maleimide-terminated poly (ethylene glycol) (PEG-4MAL), that present cell adhesive molecules and enzymatic degradation substrates and promote polarized epithelial cyst differentiation in vitro. To investigate the influence of matrix physical and biochemical signals on cyst morphogenesis, we independently varied the polymer weight percentage (wt%), the density of a cell adhesion ligand (RGD), and crosslink degradation rates of the hydrogels. Then, we evaluated functional outcomes including Madin-Darby canine kidney (MDCK II) epithelial cell survival, proliferation, cyst polarization, and lumen formation. We found that cell proliferation, but not cell survival, was sensitive to the polymer wt%, which is related to elastic modulus and crosslink density. This result defined a working range of PEG-4MAL concentration (3.5% - 4.5%) that promotes robust proliferation. Analysis of mature cysts indicated that 4.0% and 4.5% gels produced cysts resembling those typically grown in type I collagen gels while 3.5% gels produced cysts with higher incidence of inverted polarity and multiple lumens. Perturbation of matrix degradability using a slow-degrading crosslink peptide or matrix metalloproteinase inhibitors showed that the rate of matrix degradation exerts major influence on cyst growth in PEG-4MAL gels. We employed 4.0% PEG-4MAL hydrogels with RGD ligand density ranging over 0 – 2000 uM to discover that (1) lumen formation was eliminated in the absence of RGD, (2) extent of lumen formation increased with increasing RGD concentration, and (3) cyst polarity was inverted below a threshold of integrin binding to RGD. Together, these results show that the biochemical and physical properties of the matrix, particularly integrin binding and matrix degradability,… Advisors/Committee Members: García, Andrés (advisor), Nusrat, Asma (committee member), Barker, Thomas H. (committee member), Collard, David M. (committee member), Dixon, J. Brandon (committee member).

Subjects/Keywords: Biomaterials; Polyethylene glycol; Epithelial morphogenesis; Cyst; Extracellular matrix; Epithelial cells

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APA (6^th Edition):

Enemchukwu, N. O. (2013). Bioartificial matrices to modulate epithelial morphogenesis. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/52938

Chicago Manual of Style (16^th Edition):

Enemchukwu, Nduka Obichukwu. “Bioartificial matrices to modulate epithelial morphogenesis.” 2013. Doctoral Dissertation, Georgia Tech. Accessed February 28, 2021. http://hdl.handle.net/1853/52938.

MLA Handbook (7^th Edition):

Enemchukwu, Nduka Obichukwu. “Bioartificial matrices to modulate epithelial morphogenesis.” 2013. Web. 28 Feb 2021.

Vancouver:

Enemchukwu NO. Bioartificial matrices to modulate epithelial morphogenesis. [Internet] [Doctoral dissertation]. Georgia Tech; 2013. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1853/52938.

Council of Science Editors:

Enemchukwu NO. Bioartificial matrices to modulate epithelial morphogenesis. [Doctoral Dissertation]. Georgia Tech; 2013. Available from: http://hdl.handle.net/1853/52938

Brock University

27. Reid, Charles Robert. The influence of water on the glucose affinity of hexokinase .

Degree: Department of Biological Sciences, 1995, Brock University

URL: http://hdl.handle.net/10464/2162

► In the present thesis, the role of hydration during the glucose induced conformational change of hexokinase is investigated. This is accomplished by applying the osmotic… (more)

▼ In the present thesis, the role of hydration during the glucose induced conformational change of hexokinase is investigated. This is accomplished by applying the osmotic stress technique. The osmotic stress technique is founded on varying of the activity of water in a system in order to determine ifs effects. This is accomplished by adding inert solute molecules that are excluded from the system under study. The solute molecules used within the present investigation are Polyethylene glycols (PEGs). PEGs aid in the removal of water from hexokinase by exerting osmotic pressure. The osmotic pressures of the PEG solutions are also measured with both vapour pressure osmometry and secondary osmometry with phospholipids. An interesting discovery is made in that the osmotic pressures of PEG and co-solute solutions are non-additive. This indicates that PEG concentrates co-solutes in solution by making a certain proportion of the water inaccessible. Glucose binding was measured fluorometrically and the glucose equilibrium dissociation constant (GEDC) of hexokinase is measured in solutions containing the different MW PEGs. Changes in the sensitivity of the glucose affinity with osmotic pressure allows the calculation of the change in the numbers of polymer-inaccessible water molecules upon the binding of glucose to hexokinase ~Nw. It was determined the ~Nw decreases with increases in osmotic pressure in the presence of all MW PEGs. ~Nw decreases from values between 45-290 water molecules at low pressure to approximately 15 at high pressure. There is also a molecular weight dependence observed. There are large decreases in ~Nw with osmotic pressure in the presence of PEGs above MW 1000. However, below MW 1500 changes in ~Nw with osmotic pressure are relatively small. These findings are interpreted with respect to two possible mechanisms involving changes in the conformation of hexokinase u~der osmotic pressure and the access of the PEG molecules to water surrounding hexokinase.

Subjects/Keywords: Glucokinase.; Glucose.; Hydration.; Polyethylene glycol.

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APA (6^th Edition):

Reid, C. R. (1995). The influence of water on the glucose affinity of hexokinase . (Thesis). Brock University. Retrieved from http://hdl.handle.net/10464/2162

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Reid, Charles Robert. “The influence of water on the glucose affinity of hexokinase .” 1995. Thesis, Brock University. Accessed February 28, 2021. http://hdl.handle.net/10464/2162.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Reid, Charles Robert. “The influence of water on the glucose affinity of hexokinase .” 1995. Web. 28 Feb 2021.

Vancouver:

Reid CR. The influence of water on the glucose affinity of hexokinase . [Internet] [Thesis]. Brock University; 1995. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10464/2162.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Reid CR. The influence of water on the glucose affinity of hexokinase . [Thesis]. Brock University; 1995. Available from: http://hdl.handle.net/10464/2162

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas – Austin

28. Spaeth, Christopher Scott. cAMP and oxidative mechanisms of plasmalemmal sealing and the effects on rapid and long lasting repair of severed axons in vivo by polyethylene Glycol.

Degree: PhD, Cell and Molecular Biology, 2011, University of Texas – Austin

URL: http://hdl.handle.net/2152/ETD-UT-2011-05-2670

► Traumatic neuronal injury inevitably causes plasmalemmal damage, and sometimes leads to axonal severance. For any eukaryotic cell to survive following traumatic injury, the plasmalemma must… (more)

▼ Traumatic neuronal injury inevitably causes plasmalemmal damage, and sometimes leads to axonal severance. For any eukaryotic cell to survive following traumatic injury, the plasmalemma must be repaired (sealed). Plasmalemmal sealing occurs via a Ca²⁺-dependent accumulation of vesicles or other membranous structures that form a plug at the damage site. Using uniquely identified and damaged rat hippocampal B104 cells that extend neurites with axonal properties, or rat sciatic nerves, plasmalemmal sealing is assessed by exclusion of an extracellular dye from each damaged B104 cell, or sciatic nerves ex vivo. B104 cells with neurites transected nearer (<50 [micrometres]) to the soma seal at a lower frequency and slower rate compared to cells with neurites transected farther (>50 [micrometres]) from the soma. Sealing in B104 cells is enhanced by 1) increased [cAMP], 2) increased PKA activity, 3) increased Epac activity, 4) H₂O₂ and 5) Poly-ethylene glycol (PEG). Sealing is decreased by 1) PKA inhibition, 2), Botulinum toxins A, B, E, 3) Tetanus toxin 4), NEM, 5) Brefeldin A, 6) nPKC inhibition, 7) DTT, 8) Melatonin and 9) Methylene Blue. Substances (NEM, Bref A, PKI, db-cAMP, PEG) that affect plasmalemmal sealing in B104 cells in vitro have similar effects on plasmalemmal sealing in rat sciatic nerves ex vivo. Based on data from co-application of enhancers and inhibitors of sealing, I propose a plasmalemmal sealing model having four partly redundant, parallel pathways mediated by 1) PKA, 2) Epac, 3) cytosolic oxidation and 4) nPKCs. The identification and confirmation of these pathways may provide novel clinical targets for repairing and/or recovery from traumatic injury. The fusogenic compound PEG rapidly repairs axonal continuity of severed axons, potentially by rejoining severed proximal and distal axons. PEG-fusion is influenced by plasmalemmal sealing, since unsealed axons are easier to PEG fuse. I demonstrate that PEG restores morphological continuity, and improves behavioral recovery following crush-severance to sciatic nerves in rats in vivo. Co-application of Mel or MB prior to PEG application further improves PEG fusion (as measured by electrophysiology) and behavioral recovery following crush-severance in vivo. These PEG data may provide novel clinical techniques for rapidly repairing axonal severance. Advisors/Committee Members: Bittner, George D. (advisor), Zakon, Harold (committee member), Ben-Yakar, Adela (committee member), Morgan, Jennifer (committee member), Dalby, Kevin (committee member).

Subjects/Keywords: cAMP; PKA; Epac; Cytosolic oxidation; Polyethylene glycol; Plasmalemmal sealing

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APA (6^th Edition):

Spaeth, C. S. (2011). cAMP and oxidative mechanisms of plasmalemmal sealing and the effects on rapid and long lasting repair of severed axons in vivo by polyethylene Glycol. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/ETD-UT-2011-05-2670

Chicago Manual of Style (16^th Edition):

Spaeth, Christopher Scott. “cAMP and oxidative mechanisms of plasmalemmal sealing and the effects on rapid and long lasting repair of severed axons in vivo by polyethylene Glycol.” 2011. Doctoral Dissertation, University of Texas – Austin. Accessed February 28, 2021. http://hdl.handle.net/2152/ETD-UT-2011-05-2670.

MLA Handbook (7^th Edition):

Spaeth, Christopher Scott. “cAMP and oxidative mechanisms of plasmalemmal sealing and the effects on rapid and long lasting repair of severed axons in vivo by polyethylene Glycol.” 2011. Web. 28 Feb 2021.

Vancouver:

Spaeth CS. cAMP and oxidative mechanisms of plasmalemmal sealing and the effects on rapid and long lasting repair of severed axons in vivo by polyethylene Glycol. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2011. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/2152/ETD-UT-2011-05-2670.

Council of Science Editors:

Spaeth CS. cAMP and oxidative mechanisms of plasmalemmal sealing and the effects on rapid and long lasting repair of severed axons in vivo by polyethylene Glycol. [Doctoral Dissertation]. University of Texas – Austin; 2011. Available from: http://hdl.handle.net/2152/ETD-UT-2011-05-2670

29. Britt, Joshua Martin. Rapid repair of severed mammalian axons via polyethylene glycol-mediated cell fusion.

Degree: PhD, Psychology, 2014, University of Texas – Austin

URL: http://hdl.handle.net/2152/24919

► The ability to repair damaged mammalian axons to re-establish functional connections continues to be a goal for neuroscientists. Following axonal severance, proximal segments of mammalian… (more)

Subjects/Keywords: Polyethylene glycol; Axonal repair

…Murray, 2001). It is less widely known that the hydrophilic polymer polyethylene glycol… …has developed a technique to improve the speed of PNS repair using solutions of polyethylene… …glycol (PEG) to rapidly (within minutes) and directly reestablish…

11 more images…

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APA (6^th Edition):

Britt, J. M. (2014). Rapid repair of severed mammalian axons via polyethylene glycol-mediated cell fusion. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/24919

Chicago Manual of Style (16^th Edition):

Britt, Joshua Martin. “Rapid repair of severed mammalian axons via polyethylene glycol-mediated cell fusion.” 2014. Doctoral Dissertation, University of Texas – Austin. Accessed February 28, 2021. http://hdl.handle.net/2152/24919.

MLA Handbook (7^th Edition):

Britt, Joshua Martin. “Rapid repair of severed mammalian axons via polyethylene glycol-mediated cell fusion.” 2014. Web. 28 Feb 2021.

Vancouver:

Britt JM. Rapid repair of severed mammalian axons via polyethylene glycol-mediated cell fusion. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2014. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/2152/24919.

Council of Science Editors:

Britt JM. Rapid repair of severed mammalian axons via polyethylene glycol-mediated cell fusion. [Doctoral Dissertation]. University of Texas – Austin; 2014. Available from: http://hdl.handle.net/2152/24919

Michigan State University

30. Mathur, Arvind Mohan. Synthesis and characterization of polymeric pseudocrown ethers and reversible block/graft copolymeric emulsifiers based upon polymer complexation.

Degree: PhD, Department of Chemical Engineering, 1996, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:25957

Subjects/Keywords: Polymers; Ethers; Polyethylene glycol

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APA (6^th Edition):

Mathur, A. M. (1996). Synthesis and characterization of polymeric pseudocrown ethers and reversible block/graft copolymeric emulsifiers based upon polymer complexation. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:25957

Chicago Manual of Style (16^th Edition):

Mathur, Arvind Mohan. “Synthesis and characterization of polymeric pseudocrown ethers and reversible block/graft copolymeric emulsifiers based upon polymer complexation.” 1996. Doctoral Dissertation, Michigan State University. Accessed February 28, 2021. http://etd.lib.msu.edu/islandora/object/etd:25957.

MLA Handbook (7^th Edition):

Mathur, Arvind Mohan. “Synthesis and characterization of polymeric pseudocrown ethers and reversible block/graft copolymeric emulsifiers based upon polymer complexation.” 1996. Web. 28 Feb 2021.

Vancouver:

Mathur AM. Synthesis and characterization of polymeric pseudocrown ethers and reversible block/graft copolymeric emulsifiers based upon polymer complexation. [Internet] [Doctoral dissertation]. Michigan State University; 1996. [cited 2021 Feb 28]. Available from: http://etd.lib.msu.edu/islandora/object/etd:25957.

Council of Science Editors:

Mathur AM. Synthesis and characterization of polymeric pseudocrown ethers and reversible block/graft copolymeric emulsifiers based upon polymer complexation. [Doctoral Dissertation]. Michigan State University; 1996. Available from: http://etd.lib.msu.edu/islandora/object/etd:25957

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