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You searched for subject:(platelet cd151). One record found.

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RMIT University

1. Saiful Rijal, K. Cell contact dependent events involving CD151 in atherosclerosis and atherothrombosis.

Degree: 2014, RMIT University

Ischaemic heart disease is the leading cause of death worldwide. Platelets are central in normal haemostasis to arrest bleeding following trauma and under pathological conditions of atherosclerotic plaque rupture and arterial thrombosis. The development of platelet thrombi leads to the clinical sequela of cardiovascular disease which in 2011 accounted for 31% of all deaths in Australia.(1) Ischaemic heart disease accounted for 14.65% of all deaths nationwide in 2011.(2) Numerous factors are implicated in increasing the thrombogenic potential of ruptured plaques including increased blood shear rates in narrowed blood vessels and responsiveness of platelet activation. CD151 is a tetraspanin amongst several found on platelets. It is a promising target in anti-platelet therapies, acting in conjunction with cognate receptors particularly integrin αIIbb3 in the regulation of platelet thrombus formation in vivo. The functional and physical associations between CD151 and integrin αIIbb3 in murine platelets emphasises the critical involvement of CD151 in modulating outside-in αIIbb3 signalling pathways.(3) A novel ApoE-/-.CD151-/- model was developed by crossing the ApoE-/- genotype with the CD151-/- genotype. CD151 has not been studied in the context of atherosclerosis and through this model, in vivo and in vitro studies were able to be performed. The ApoE-/-.CD151-/- model was characterised for its Mendelian inheritance profile, haematological and lipid parameters and cardiovascular risk factors such as body weight, age, body mass index and glucose levels. The Mendelian inheritance frequencies for the ApoE-/-.CD151-/- ­was significantly altered whilst lipid profiles showed reduced total cholesterol and high density lipoprotein cholesterol levels in comparison to ApoE-/- mice. The remaining parameters appeared normal. Preliminary histology and immunohistochemistry studies indicated a significantly reduced plaque burden in the ApoE-/-.CD151-/- mouse compared to the ApoE-/- mouse through haematoxylin and eosin staining of the aortic valve cusps. Plaque composition was unchanged in the absence of CD151 in atherosclerosis. This was determined through immunohistochemical staining for F4/80 pan macrophage markers, smooth muscle actin, type 1 collagen and CD151 expression. In vivo studies demonstrated a defect in ApoE-/-.CD151-/- platelets with prolonged times to occlusion upon FeCl3 induced vascular injury of the carotid arteries and reduced thrombus formation in comparison to ApoE-/- platelets. In vivo tail bleeding assays similarly suggested a defect of unstable haemostasis as bleeding times, volume of blood lost and rebleeds were significantly increased in the ApoE-/-.CD151-/- model. Platelet aggregation responses appeared unchanged between the strains implying that CD151 absence had no protective effect on agonist induced platelet aggregation. Furthermore, we saw a similar pattern in our in vivo studies of the mesenteric arterioles whereby, thrombus area, volume and stability…

Subjects/Keywords: Fields of Research; atherothrombosis; atherosclerosis; cd151; platelet cd151; thrombus formation

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APA (6th Edition):

Saiful Rijal, K. (2014). Cell contact dependent events involving CD151 in atherosclerosis and atherothrombosis. (Thesis). RMIT University. Retrieved from http://researchbank.rmit.edu.au/view/rmit:161280

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Saiful Rijal, K. “Cell contact dependent events involving CD151 in atherosclerosis and atherothrombosis.” 2014. Thesis, RMIT University. Accessed December 05, 2020. http://researchbank.rmit.edu.au/view/rmit:161280.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Saiful Rijal, K. “Cell contact dependent events involving CD151 in atherosclerosis and atherothrombosis.” 2014. Web. 05 Dec 2020.

Vancouver:

Saiful Rijal K. Cell contact dependent events involving CD151 in atherosclerosis and atherothrombosis. [Internet] [Thesis]. RMIT University; 2014. [cited 2020 Dec 05]. Available from: http://researchbank.rmit.edu.au/view/rmit:161280.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Saiful Rijal K. Cell contact dependent events involving CD151 in atherosclerosis and atherothrombosis. [Thesis]. RMIT University; 2014. Available from: http://researchbank.rmit.edu.au/view/rmit:161280

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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