subject:(pilocytic astrocytoma)

University of Vienna

1. Lehner, Caroline Christine. Cerebelläres pilozytisches Astrozytom.

Degree: 2008, University of Vienna

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Ziel der vorliegenden Studie ist es, zu untersuchen, ob Patienten, welche im Kindes- und Jugendalter an einem cerebellären pilozytischen Astrozytom operiert wurden und keine Chemo-… (more)

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Ziel der vorliegenden Studie ist es, zu untersuchen, ob Patienten, welche im Kindes- und Jugendalter an einem cerebellären pilozytischen Astrozytom operiert wurden und keine Chemo- bzw. Strahlentherapie erhielten, Langzeitfolgen in kognitiven und emotionalen Funktionen entwickeln. Hintergrund: Seit einiger Zeit wird dem Cerebellum neben motorischen Funktionen auch eine Modulator-Funktion von kognitiven und emotionalen Prozessen zugeschrieben. Die bidirektionalen Verbindungen des Cerebellums mit allen Ebenen des Zentralnervensystems unterstützen diese Sichtweise. Methoden: An 17 PatientInnen wurden intellektuelle, attentionale, mnestische, exekutive, verbale und visuell-räumliche Funktionen bzw. das Erkennen emotionaler Gesichtsausdrücke, das Emotionsempfinden und die aktuelle psychische Belastung erhoben. Ergebnisse: Signifikant schlechtere Leistungen wiesen die PatientInnen hinsichtlich exekutiver (semantische und formallexikalische Wortflüssigkeit) und verbaler Funktionen bzw. im Empfinden von positiven Emotionen auf. Ein vulnerables Alter für die Operation vor dem 10. Lebensjahr konnte für die Lern- und Wiedererkennensleistung bzw. für die aktuelle psychische Belastung bestätigt werden. Eine Beziehung zwischen präoperativem Hydrocephalus und visuell-räumlichen Funktionen bzw. die Rolle des Vermis für emotionale Funktionen konnte nicht nachgewiesen werden. Aufgrund fehlender Beeinträchtigungen in visuell-räumlichen Funktionen konnte auch das cerebelläre kognitiv-affektive Syndrom CCAS nicht bestätigt werden. Schlussfolgerung: Diese Ergebnisse bestätigen die Rolle des Cerebellums für kognitive und emotionale Funktionen und untermauern die Vermutung einer Unterbrechung der Verbindung des Cerebellums mit frontalen Strukturen, und einer daraus resultierenden Störung der Informationsverarbeitung.

The aim of the present study is to investigate if patients who have undergone surgery on a cerebellar pilocytic astrocytoma in their childhood or adolescence without receiving chemo- or radiotherapy develop long-term deficits in cognitive and emotional functions. Background: For some time there have been theories about the role of the cerebellum. In addition to the motoric function, it is also recognised as a modulator of cognitive and affective abilities. Bidirectional pathways of the cerebellum with all levels of the central nerve system support this view. Methods: 17 patients underwent neuropsychological assessment of intellectual, attentional, mnestic, executive, verbal and visual-spatial functions and recognition of emotion in face expression, identification of emotions and current mental problems respectively. Results: The patients’ performances were significantly worse than the norm population in consideration of executive (semantic and lexical wordfluency) and verbal functions and in feeling of positive emotions respectively. A vulnerable operation age before the age of 10 years could be afirmed for learning- and recognition performance and for current mental problems. However, a relation between preoperative…

Subjects/Keywords: 77.31 Kognition; 77.46 Emotion; 77.70 Klinische Psychologie; 44.90 Neurologie; 44.65 Chirurgie; Neuropsychologie / Neurochirurgie / cerebelläres pilozytisches Astrozytom / Langzeitfolgen / Kognition / Emotion / Emotionserkennen / Emotionsempfinden / Vermis / Cerebellum / Neuroplastizität / Hydrocephalus; neuropsychology / neurosurgery / cerebellar pilocytic astrocytoma / longterm sequelae / cognition / emotion / recognition of emotion / feeling of emotions / vermis / cerebellum / neuroplasticity / hydrocephalus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lehner, C. C. (2008). Cerebelläres pilozytisches Astrozytom. (Thesis). University of Vienna. Retrieved from http://othes.univie.ac.at/1602/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lehner, Caroline Christine. “Cerebelläres pilozytisches Astrozytom.” 2008. Thesis, University of Vienna. Accessed March 03, 2021. http://othes.univie.ac.at/1602/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lehner, Caroline Christine. “Cerebelläres pilozytisches Astrozytom.” 2008. Web. 03 Mar 2021.

Vancouver:

Lehner CC. Cerebelläres pilozytisches Astrozytom. [Internet] [Thesis]. University of Vienna; 2008. [cited 2021 Mar 03]. Available from: http://othes.univie.ac.at/1602/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lehner CC. Cerebelläres pilozytisches Astrozytom. [Thesis]. University of Vienna; 2008. Available from: http://othes.univie.ac.at/1602/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Lim, Kah Suan. Investigating novel therapies for brain tumors - the roles of MCT4, cellular senescence, and arsenic trioxide treatment.

Degree: 2014, Johns Hopkins University

URL: http://jhir.library.jhu.edu/handle/1774.2/36976

► My studies focused on characterizing signaling and metabolic pathways involved in the pathobiology of brain tumors in order to develop improved therapies. One project was… (more)

▼ My studies focused on characterizing signaling and metabolic pathways involved in the pathobiology of brain tumors in order to develop improved therapies. One project was centered on investigating oncogenic KIAA1549-BRAF fusion induced senescence as a growth suppressive mechanism in pilocytic astrocytoma. We found that loss of expression of tumor suppressor p16 lead to significantly decreased survival in pilocytic astrocytoma patients. Another major focus was on metabolic targeting in glioblastoma cells. We found that the lactate exporter MCT4 was specifically upregulated under hypoxic conditions in glioblastoma cells, and its overexpression was significantly linked to survival. Silencing MCT4 in glioblastoma neurospheres led to decreased growth in vitro and in vivo, inhibition of clonogenic capacity, and reductions in CD133-positive stem-like tumor cells. This was partially due to an induction of apoptosis. Interestingly, we found that this apoptotic induction and growth inhibition was not due to lack of lactate export, but instead, due to an inhibition of the HIF response, highlighting the importance of aberrant metabolic regulation in cancer. Finally, we investigated the possibility of targeting Notch and Hedgehog signaling simultaneously in glioblastoma neurospheres using arsenic trioxide. We found that aberrant Notch and Hedgehog pathway signaling was decreased following arsenic trioxide treatment, and this decrease was accompanied by decreased neurosphere growth and proliferation, decreased clonogenic capacity, decreased CD133-positive cells, and increased apoptosis. These studies thus identify mechanisms by which several hallmarks of cancer are altered in brain tumors, and our preclinical data suggest some potential therapeutic applications. However, it is important to note that targeting only one or two hallmark changes in cancer often leads to therapeutic resistance, and multimodal therapies will likely be necessary if we are to cure aggressive brain tumors. Advisors/Committee Members: Semenza, Gregg (advisor).

Subjects/Keywords: Brain tumors; pilocytic astrocytoma; glioblastoma

…INK4a 2.3.3 Lack of expression of the senescence marker p16 in pilocytic astrocytoma is… …28 2.3.4 Primary cultures of KIAA1549:BRAF fusion containing pilocytic astrocytoma express… …44 3.2.1 Pilocytic Astrocytoma (WHO Grade I)… …126 6.1 Advances in Our Knowledge of Pilocytic Astrocytoma Biology ..................... 126… …pilocytic astrocytoma cells with or without p16INK4a…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lim, K. S. (2014). Investigating novel therapies for brain tumors - the roles of MCT4, cellular senescence, and arsenic trioxide treatment. (Thesis). Johns Hopkins University. Retrieved from http://jhir.library.jhu.edu/handle/1774.2/36976

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lim, Kah Suan. “Investigating novel therapies for brain tumors - the roles of MCT4, cellular senescence, and arsenic trioxide treatment.” 2014. Thesis, Johns Hopkins University. Accessed March 03, 2021. http://jhir.library.jhu.edu/handle/1774.2/36976.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lim, Kah Suan. “Investigating novel therapies for brain tumors - the roles of MCT4, cellular senescence, and arsenic trioxide treatment.” 2014. Web. 03 Mar 2021.

Vancouver:

Lim KS. Investigating novel therapies for brain tumors - the roles of MCT4, cellular senescence, and arsenic trioxide treatment. [Internet] [Thesis]. Johns Hopkins University; 2014. [cited 2021 Mar 03]. Available from: http://jhir.library.jhu.edu/handle/1774.2/36976.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lim KS. Investigating novel therapies for brain tumors - the roles of MCT4, cellular senescence, and arsenic trioxide treatment. [Thesis]. Johns Hopkins University; 2014. Available from: http://jhir.library.jhu.edu/handle/1774.2/36976

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

3. Lüth, Maria. Analysis of mitochondrial DNA mutations in patients with neuroectodermal tumors.

Degree: 2011, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/13747

► To detect somatic mitochondrial DNA mutations in neuroectodermal tumors, mutation analysis in patients with medulloblastoma, pilocytic astrocytoma and neurofibromatosis type 1-associated tumors was performed. MtDNA… (more)

▼ To detect somatic mitochondrial DNA mutations in neuroectodermal tumors, mutation analysis in patients with medulloblastoma, pilocytic astrocytoma and neurofibromatosis type 1-associated tumors was performed. MtDNA alterations in the entire mitochondrial genome were analyzed by temporal temperature gradient gelelectrophoresis followed by DNA sequencing. We have analyzed the entire mitochondrial genome in 15 cases of medulloblastoma and the corresponding cerebrospinal fluid (CSF) samples in 10 of the 15 cases. Six of the fifteen cases (40%) showed at least one mtDNA mutation in the tumors. A total of 18 somatic mtDNA mutations were detected with one of the tumors having 11 mutations of which 9 were novel. Three of the six cases with mtDNA mutation also showed mutation in the cell-free CSF collected at various times during therapy. Somatic mtDNA mutations in tumors were found in 7 of 19 individuals with cutaneous neurofibromas and in 9 of 18 patients with plexiform neurofibromas. A total of 34 somatic mtDNA mutations were found. All mutations were located in the displacement loop region of the mitochondrial genome. Several plexiform neurofibromas from individual patients had multiple homoplasmic mtDNA mutations. In cutaneous neurofibromas, the same mtDNA mutations were always present in tumors from different locations of the same individual. An increase in the proportion of the mutant mtDNA was always found in the neurofibromas when compared with nontumor tissues. The somatic mtDNA mutations were present in the Schwann cells of the analyzed multiple cutaneous neurofibromas of the same individual. The observed dominance of a single mtDNA mutation in multiple cutaneous neurofibromas of individual patients indicates a common tumor cell ancestry and suggests a replicative advantage rather than random segregation for cells carrying these mutated mitochondria. Advisors/Committee Members: [email protected] (contact), w (gender), PD Dr. med. P. Hernáiz-Driever (firstReferee), Prof. Dr. med. M. Hasselblatt (furtherReferee), Prof. Dr. med. F. Aksu (furtherReferee).

Subjects/Keywords: mtDNA; somatic mutations; neurofibromatosis type 1-associated tumors; pilocytic astrocytoma; medulloblastoma; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lüth, M. (2011). Analysis of mitochondrial DNA mutations in patients with neuroectodermal tumors. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/13747

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lüth, Maria. “Analysis of mitochondrial DNA mutations in patients with neuroectodermal tumors.” 2011. Thesis, Freie Universität Berlin. Accessed March 03, 2021. https://refubium.fu-berlin.de/handle/fub188/13747.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lüth, Maria. “Analysis of mitochondrial DNA mutations in patients with neuroectodermal tumors.” 2011. Web. 03 Mar 2021.

Vancouver:

Lüth M. Analysis of mitochondrial DNA mutations in patients with neuroectodermal tumors. [Internet] [Thesis]. Freie Universität Berlin; 2011. [cited 2021 Mar 03]. Available from: https://refubium.fu-berlin.de/handle/fub188/13747.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lüth M. Analysis of mitochondrial DNA mutations in patients with neuroectodermal tumors. [Thesis]. Freie Universität Berlin; 2011. Available from: https://refubium.fu-berlin.de/handle/fub188/13747

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

4. Mercurio, Sandy. Mise en évidence de nouvelles cibles thérapeutiques dans les tumeurs gliales et glioneuronales de l'enfant : Evidence of new therapeutic targets in glial and glioneuronal pediatric tumors.

Degree: Docteur es, Biologie. Immunologie, 2013, Aix Marseille Université

URL: http://www.theses.fr/2013AIXM5094

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Les tumeurs gliales et glioneuronales sont les tumeurs cérébrales les plus fréquentes chez l'enfant. Elles sont généralement d'excellent pronostic. En revanche, les astrocytomes pilocytiques (AP)… (more)

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Les tumeurs gliales et glioneuronales sont les tumeurs cérébrales les plus fréquentes chez l'enfant. Elles sont généralement d'excellent pronostic. En revanche, les astrocytomes pilocytiques (AP) hypothalamo-chiasmatiques, ont un potentiel évolutif plus agressif. Ce travail de thèse propose une nouvelle stratégie thérapeutique pour ce sous-type d'AP selon la méthode du « drug repositioning », en employant la combinaison du celecoxib et de la fluvastatine. Nos travaux ont montré in vitro que cette association de molécules était synergique, capable d'arrêter le cycle cellulaire, de diminuer la prolifération et d'induire l'apoptose des cellules tumorales. Cette combinaison a également été testée avec succès chez une patiente souffrant d'un AP multifocal et réfractaire aux traitements conventionnels dans le cadre d'une thérapie métronomique. Ce manuscrit décrit également l'étude histo-moléculaire de plusieurs séries de tumeurs gliales et glioneuronales pédiatriques menées afin d'améliorer leur caractérisation et leur diagnostic. Nos travaux ont confirmé la présence de la fusion KIAA1549:BRAF dans les AP analysés ainsi que le caractère péjoratif de la topographie hypothalamo-chiasmatique, du variant histologique pilomyxoïde et de l'âge au diagnostic inférieur à 36 mois. Ils ont également montré l'absence de différence moléculaire entre les gliomes corticaux de grade II et des DNT. Enfin, nos travaux ont montré que les DNT, les GG et les PXA partagent la mutation BRAFV600E et l'expression de CD34. Ces travaux confirment l'implication majeure de l'altération de la voie des MAPKinases dans la tumorigenèse de ces tumeurs, constituant ainsi une cible thérapeutique prometteuse.

Glial and glioneuronal tumors are the most frequent brain tumors in children. They are characterized by an excellent prognosis. However, hypothalamic-chiasmatic pilocytic astrocytomas (PA) have a more aggressive outcome. In the first part, we propose a new therapeutic strategy for hypothalamic-chiasmatic PA according to drug repositioning method, by using celecoxib, and fluvastatin. We showed that, in vitro, this combination was synergistic, stopped cell cycle, inhibited cell proliferation and increased apoptosis. In addition, this combination was tested with success, under a metronomic chemotherapy, for a girl suffering from a multifocal PA and refractory to conventional treatment. This new strategy of treatment appears promising for this type of tumor because it is less toxic than conventional chemotherapy and not too expensive. In the second part, this manuscript describes the histo-molecular study of several retrospective series of glial and glioneuronal pediatric tumors conducted to improve their characterization and their diagnosis. We confirmed the presence of the fusion gene KIAA1549: BRAF in PA as well as the pejorative nature of the hypothalamic-chiasmatic topography, pilomyxoïde histology and the age at diagnosis less than 36 months. We also showed no molecular difference between cortical grade II gliomas associated with chronic epilepsy…

Advisors/Committee Members: Figarella-Branger, Dominique (thesis director).

Subjects/Keywords: Tumeurs cérébrales pédiatriques,fluvastatine/celecoxib,drug repositioning,astrocytome pilocytique,profil moléculaire,BRAF; Pediatric brain tumors,fluvastatin/celecoxib,drug repositioning,pilocytic astrocytoma,molecular profil,BRAF

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mercurio, S. (2013). Mise en évidence de nouvelles cibles thérapeutiques dans les tumeurs gliales et glioneuronales de l'enfant : Evidence of new therapeutic targets in glial and glioneuronal pediatric tumors. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2013AIXM5094

Chicago Manual of Style (16^th Edition):

Mercurio, Sandy. “Mise en évidence de nouvelles cibles thérapeutiques dans les tumeurs gliales et glioneuronales de l'enfant : Evidence of new therapeutic targets in glial and glioneuronal pediatric tumors.” 2013. Doctoral Dissertation, Aix Marseille Université. Accessed March 03, 2021. http://www.theses.fr/2013AIXM5094.

MLA Handbook (7^th Edition):

Mercurio, Sandy. “Mise en évidence de nouvelles cibles thérapeutiques dans les tumeurs gliales et glioneuronales de l'enfant : Evidence of new therapeutic targets in glial and glioneuronal pediatric tumors.” 2013. Web. 03 Mar 2021.

Vancouver:

Mercurio S. Mise en évidence de nouvelles cibles thérapeutiques dans les tumeurs gliales et glioneuronales de l'enfant : Evidence of new therapeutic targets in glial and glioneuronal pediatric tumors. [Internet] [Doctoral dissertation]. Aix Marseille Université 2013. [cited 2021 Mar 03]. Available from: http://www.theses.fr/2013AIXM5094.

Council of Science Editors:

Mercurio S. Mise en évidence de nouvelles cibles thérapeutiques dans les tumeurs gliales et glioneuronales de l'enfant : Evidence of new therapeutic targets in glial and glioneuronal pediatric tumors. [Doctoral Dissertation]. Aix Marseille Université 2013. Available from: http://www.theses.fr/2013AIXM5094

5. Padovani, Laëtitia. Caractérisation moléculaire des tumeurs cérébrales circonscrites de l'enfant : Molecular caracteristics of low grade pediatric brain tumors.

Degree: Docteur es, Neurosciences, 2013, Aix Marseille Université

URL: http://www.theses.fr/2013AIXM5018

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La classification OMS des tumeurs cérébrales de l'enfant distingue les tumeurs gliales des tumeurs glioneuronales, les gliomes circonscrits des infiltrants. Elle représente le meilleur indicateur… (more)

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La classification OMS des tumeurs cérébrales de l'enfant distingue les tumeurs gliales des tumeurs glioneuronales, les gliomes circonscrits des infiltrants. Elle représente le meilleur indicateur pronostic mais se heurte pourtant à des limites de reproductibilité. Pour mieux préciser le diagnostic, mieux définir des sous-groupes de pronostic différent, et mieux orienter le thérapeutique, nous avons recherché les profils moléculaires de 108 tumeurs cérébrales circonscrites de l'enfant : astrocytome pilocytique (PA), tumeurs neuroépithéliales dysembryoplasiques (DNT), xanthoastrocytomes pléïomorphes (PXA) et gangliogliomes (GG). Aucune différence n'est retrouvée entre les gliomes corticaux de grade II (GC) et les DNT concernant IDH1 et 2, TP53 et la délétion1p19q. Les DNT non spécifiques et les GC partagent le même profil incluant CD34 et la mutation V600E de BRAF dans 50% des cas. Le PXA exprime la mutation V600E de BRAF dans plus de 50 % des cas et se rapproche du groupe des tumeurs glioneuronales. Concernant le PA, nous confirmons le caractère péjoratif de la topographie hypothalamo-chiasmatique, de l'histologie pilomyxoide, de l'âge inférieur à 36 mois et de l'exérèse partielle. A l'opposé des tumeurs infiltrantes qui appartiendraient au groupe " histones dépendantes", les tumeurs circonscrites pourraient être regroupées sous le terme "MAPKinases dépendantes". On y distinguerait alors les tumeurs avec fusion KIAA1543-BRAF de celles avec mutation V600E de BRAF. Ce travail a permis de mieux caractériser les tumeurs gliales et glioneuronales de l'enfant, reposant sur le transfert en routine de marqueurs moléculaires simples.

The OMS classification for pediatric brain tumors includes glial tumors and mixed glial and glioneuronal tumors, diffuse and no diffuse glioma. All strategic decision making are based on this current classification but it drives to some limits of diagnosis reproductibility.The goal of our study was to define molecular profils for low grade no diffuse pediatric brain tumors including pilocytic astrocytoma (PA), dysembryoplasic neuroepithelial tumor (DNT), pleiomorphic xanthoastrocytoma (PXA) and benign gangliogliome (GG), to improve the quality of diagnosis, define different subgroups with different prognosis and then to improve treatment strategy decision making.No molecular difference was found between cortical grade II glioma (GC) and DNT regarding IDH1 and 2 TP53 alterations and 1p19q deletion. Similarly 50 % of no specific form of DNT share the same molecular profil with GC with CD34 expression and V600E mutation of BRAF. PXA demonstrated BRAFV600E mutation in 60 % of cases. PXA could then be very close glioneuronal tumors. Finally in PA we confirmed the negative impact of hypothalochiasmatic location, pilomyxoid diagnosis and age lower than 36 months and partial resection. We could work on the elaboration of a new classification and define the group named “Histone dependant” for tumors with histone aberrations and the group named “MAPKinases dependant” for tumors with either KIAA 1543-BRAF…

Advisors/Committee Members: Figarella-Branger, Dominique (thesis director).

Subjects/Keywords: Braf, tumeurs cérébrales pediatriques, profil moléculaire, dnt, tumeurs circonscrites, astocytome pilocytique, gangliogliome; Braf, pediatric brain tumors, molecular profil, DNT, low grade glioma, pilocytic astrocytoma, ganglioglioma

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Padovani, L. (2013). Caractérisation moléculaire des tumeurs cérébrales circonscrites de l'enfant : Molecular caracteristics of low grade pediatric brain tumors. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2013AIXM5018

Chicago Manual of Style (16^th Edition):

Padovani, Laëtitia. “Caractérisation moléculaire des tumeurs cérébrales circonscrites de l'enfant : Molecular caracteristics of low grade pediatric brain tumors.” 2013. Doctoral Dissertation, Aix Marseille Université. Accessed March 03, 2021. http://www.theses.fr/2013AIXM5018.

MLA Handbook (7^th Edition):

Padovani, Laëtitia. “Caractérisation moléculaire des tumeurs cérébrales circonscrites de l'enfant : Molecular caracteristics of low grade pediatric brain tumors.” 2013. Web. 03 Mar 2021.

Vancouver:

Padovani L. Caractérisation moléculaire des tumeurs cérébrales circonscrites de l'enfant : Molecular caracteristics of low grade pediatric brain tumors. [Internet] [Doctoral dissertation]. Aix Marseille Université 2013. [cited 2021 Mar 03]. Available from: http://www.theses.fr/2013AIXM5018.

Council of Science Editors:

Padovani L. Caractérisation moléculaire des tumeurs cérébrales circonscrites de l'enfant : Molecular caracteristics of low grade pediatric brain tumors. [Doctoral Dissertation]. Aix Marseille Université 2013. Available from: http://www.theses.fr/2013AIXM5018

Freie Universität Berlin

6. Rückriegel, Stefan Mark. Tumor- and therapy-associated neurotoxicity in children and adolescents with posterior fossa tumors.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-11848

► Motor and cognitive function losses resemble handicaps in pediatric posterior fossa tumor survivors. Several factors determine type and extent of impairment. We quantified loss of… (more)

Subjects/Keywords: medulloblastoma; pilocytic astrocytoma; sequelae; diffusion tensor imaging; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rückriegel, S. M. (2010). Tumor- and therapy-associated neurotoxicity in children and adolescents with posterior fossa tumors. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-11848

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rückriegel, Stefan Mark. “Tumor- and therapy-associated neurotoxicity in children and adolescents with posterior fossa tumors.” 2010. Thesis, Freie Universität Berlin. Accessed March 03, 2021. http://dx.doi.org/10.17169/refubium-11848.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rückriegel, Stefan Mark. “Tumor- and therapy-associated neurotoxicity in children and adolescents with posterior fossa tumors.” 2010. Web. 03 Mar 2021.

Vancouver:

Rückriegel SM. Tumor- and therapy-associated neurotoxicity in children and adolescents with posterior fossa tumors. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2021 Mar 03]. Available from: http://dx.doi.org/10.17169/refubium-11848.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rückriegel SM. Tumor- and therapy-associated neurotoxicity in children and adolescents with posterior fossa tumors. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-11848

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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