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You searched for subject:(orthopedic infection). Showing records 1 – 2 of 2 total matches.

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1. Lu, Chao-yi. Modified Cyclodextrin Microparticles to Improve PMMA Drug Delivery Without Mechanical Loss.

Degree: MSs, Biomedical Engineering, 2020, Case Western Reserve University School of Graduate Studies

Antibiotic-loaded poly(methyl methacrylate) (PMMA) cement is commonly used as a local delivery system to treat and prevent orthopedic infections associated with arthroplasties in load-bearing applications. However, these delivery systems are inefficient as release rate sharply declines to subinhibitory levels. Prior studies have shown that by adding in drug-filled cyclodextrin (CD) microparticles into PMMA cement, a more consistent release was observed. Additionally, antibiotic refilling through simulated implantation was achieved, but a loss in mechanical properties was noticed. In order to decrease the mechanical loss, modified CD microparticles (PMMA-CD) were synthesized. The compressive strengths, handling characteristics, and refilling ability of PMMA with PMMA-CD were evaluated. Up to a 10% increase in compressive strength was observed when CD was substituted with PMMA-CD. A longer working time and lower maximum temperature were observed with both the addition of CD and of PMMA-CD into PMMA, and refilling was also observed in PMMA with PMMA-CD. Advisors/Committee Members: von Recum, Horst (Advisor).

Subjects/Keywords: Biomedical Engineering; Drug delivery; orthopedic infection; polymer; cyclodextrin; PMMA

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Lu, C. (2020). Modified Cyclodextrin Microparticles to Improve PMMA Drug Delivery Without Mechanical Loss. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1586361699051386

Chicago Manual of Style (16th Edition):

Lu, Chao-yi. “Modified Cyclodextrin Microparticles to Improve PMMA Drug Delivery Without Mechanical Loss.” 2020. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed October 29, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1586361699051386.

MLA Handbook (7th Edition):

Lu, Chao-yi. “Modified Cyclodextrin Microparticles to Improve PMMA Drug Delivery Without Mechanical Loss.” 2020. Web. 29 Oct 2020.

Vancouver:

Lu C. Modified Cyclodextrin Microparticles to Improve PMMA Drug Delivery Without Mechanical Loss. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2020. [cited 2020 Oct 29]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1586361699051386.

Council of Science Editors:

Lu C. Modified Cyclodextrin Microparticles to Improve PMMA Drug Delivery Without Mechanical Loss. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2020. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1586361699051386


University of Western Ontario

2. Khazaee, Tina. Characterization and Enhancement of Local Drug Delivery in Orthopaedic Infection.

Degree: 2020, University of Western Ontario

The delivery of antibiotics is an important component of therapy for orthopedic device-related infections (ODRI). In this study, we have investigated new techniques to characterize and enhance antibiotic delivery for ODRI. Characterization of small-molecule diffusion is essential to the development of drug-delivery systems. We have developed a quantitative, non-invasive, longitudinal, micro-CT technique to quantify the diffusion of small-molecules in an intact phantom. We employed a radio-opaque molecule (i.e., Iohexol) as a surrogate for commonly used antibiotics (e.g., Vancomycin). We characterized diffusion from a finite-core carrier into an agar, tissue-equivalent phantom. The estimate of the diffusion coefficient was derived from the analysis of radial diffusion distance of Iohexol and the cumulative release amount of this drug surrogate. This micro-CT method enabled us to describe the elution of small-molecules from enhanced carriers within a porous metal scaffold. To enhance antibiotic delivery, we designed and fabricated gyroid-based scaffolds with appropriate mechanical properties and filled with Iohexol-loaded carriers. Diffusion characteristics within the porous structures were evaluated using the micro-CT technique.

Subjects/Keywords: Diffusion; small-molecules; local drug delivery; micro-CT; drug-surrogate; contrast agent; orthopedic device-related infection; 3D-printed porous scaffold.; Medical Biophysics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Khazaee, T. (2020). Characterization and Enhancement of Local Drug Delivery in Orthopaedic Infection. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/6851

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Khazaee, Tina. “Characterization and Enhancement of Local Drug Delivery in Orthopaedic Infection.” 2020. Thesis, University of Western Ontario. Accessed October 29, 2020. https://ir.lib.uwo.ca/etd/6851.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Khazaee, Tina. “Characterization and Enhancement of Local Drug Delivery in Orthopaedic Infection.” 2020. Web. 29 Oct 2020.

Vancouver:

Khazaee T. Characterization and Enhancement of Local Drug Delivery in Orthopaedic Infection. [Internet] [Thesis]. University of Western Ontario; 2020. [cited 2020 Oct 29]. Available from: https://ir.lib.uwo.ca/etd/6851.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Khazaee T. Characterization and Enhancement of Local Drug Delivery in Orthopaedic Infection. [Thesis]. University of Western Ontario; 2020. Available from: https://ir.lib.uwo.ca/etd/6851

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.