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Penn State University

1. Tabakovic, Amra. Investigation of Laundering and Dispersion Approaches for Silica and Calcium Phosphosilicate Nanoparticles Synthesized in Reverse Micelles.

Degree: 2015, Penn State University

Nanotechnology, the science and engineering of materials at the nanoscale, is a booming research area with numerous applications in electronic, cosmetic, automotive and sporting goods industries, as well as in biomedicine. Composite nanoparticles (NPs) are of special interest since the use of two or more materials in NP design imparts multifunctionality on the final NP constructs. This is especially relevant for applications in areas of human healthcare, where the use of dye or drug doped composite NPs is expected to improve the diagnosis and treatment of cancer and other serious illnesses. Since the physicochemical properties of NP suspensions dictate the success of these systems in biomedical applications, especially drug delivery of chemotherapeutics, synthetic routes which offer precise control of NP properties, especially particle diameter and colloidal stability, are utilized to form a variety of composite NPs. Formation of NPs in reverse, or water-in-oil, micelles is one such synthetic approach. However, while the use of reverse micelles to form composite NPs offers precise control over NP size and shape, the post-synthesis laundering and dispersion of synthesized NP suspensions can still be a challenge. Reverse micelle synthetic approaches require the use of surfactants and low dielectric constant solvents, like hexane and cyclohexane, as the oil phase, which can compromise the biocompatibility and colloidal stability of the final composite NP suspensions. Therefore, appropriate dispersants and solvents must be used during laundering and dispersion to remove surfactant and ensure stability of synthesized NPs. In the work presented in this dissertation, two laundering and dispersion approaches, including packed column high performance liquid chromatography (HPLC) and centrifugation (sedimentation and redispersion), are investigated for silver core silica (Ag-SiO2) and calcium phosphosilicate (Caw(HxPO4)y(Si(OH)zOa)b.cH2O, CPS) composite NP suspensions synthesized in a cyclohexane/ polyoxyethylene (5) nonylphenylether (IgepalĀ® CO-520) /water reverse micelle system. In Chapter 3, an HPLC laundering and dispersion approach for Ag-SiO2 composite NPs is studied. The deposition and detachment behavior of 5 w/w 3- aminopropyltriethoxy silane (APTES) dispersed Ag-SiO2 suspensions on 1 w/o, 5 w/o and 15 w/o APTES treated SiO2 column stationary phase microspheres is investigated with respect to final % mass yields for collected NP suspensions. Field emission scanning electron microscopy (FESEM) studies confirm multilayer deposition of Ag-SiO2 NPs during loading and retention on the column during laundering stages of the process independent of w/o APTES treatment on stationary phase microspheres, with individual deposited Ag-SiO2 NPs observed to be in the 20-30 nm diameter range. Patchy deposition patterns and irreversible agglomeration are also confirmed via FESEM, as fractions of loaded Ag-SiO2 NPs remain attached on the 1 w/o, 5 w/o and 15 w/o APTES stationary phases after completion of the collecting… Advisors/Committee Members: James Hansell Adair, Dissertation Advisor/Co-Advisor, Gary Lynn Messing, Committee Member, Gail Lynn Matters, Committee Member, Christine Dolan Keating, Committee Member.

Subjects/Keywords: Nanoparticles; nanoparticle laundering; nanotechnology; biomedicine; drug delivery

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APA (6th Edition):

Tabakovic, A. (2015). Investigation of Laundering and Dispersion Approaches for Silica and Calcium Phosphosilicate Nanoparticles Synthesized in Reverse Micelles. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/26559

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Tabakovic, Amra. “Investigation of Laundering and Dispersion Approaches for Silica and Calcium Phosphosilicate Nanoparticles Synthesized in Reverse Micelles.” 2015. Thesis, Penn State University. Accessed March 04, 2021. https://submit-etda.libraries.psu.edu/catalog/26559.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Tabakovic, Amra. “Investigation of Laundering and Dispersion Approaches for Silica and Calcium Phosphosilicate Nanoparticles Synthesized in Reverse Micelles.” 2015. Web. 04 Mar 2021.

Vancouver:

Tabakovic A. Investigation of Laundering and Dispersion Approaches for Silica and Calcium Phosphosilicate Nanoparticles Synthesized in Reverse Micelles. [Internet] [Thesis]. Penn State University; 2015. [cited 2021 Mar 04]. Available from: https://submit-etda.libraries.psu.edu/catalog/26559.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tabakovic A. Investigation of Laundering and Dispersion Approaches for Silica and Calcium Phosphosilicate Nanoparticles Synthesized in Reverse Micelles. [Thesis]. Penn State University; 2015. Available from: https://submit-etda.libraries.psu.edu/catalog/26559

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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