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University of Rochester
1.
Hine, Christopher M.; Gorbunova, Vera.
Defying and Defeating Cancer: Hyaluronic Acid and the
Rad51 Promoter.
Degree: PhD, 2011, University of Rochester
URL: http://hdl.handle.net/1802/15811 
► Cancer is one of the top three leading causes of death worldwide. Its physical, social and economic impact on patients, their families and society are…
(more)
▼ Cancer is one of the top three leading causes of
death worldwide. Its physical, social and economic impact on
patients, their families and society are devastating. Basic,
translational and clinical research that encompasses cancer
prevention, diagnosis and treatment are essential and needed to
lower or eradicate the incidence of this disease. To address this
issue, I compared: (1) Tumor suppressive mechanisms in long and
short-lived mammals and (2) Rad51 promoter-based construct activity
in cancerous and noncancerous human cells for the development of
targeted cancer gene therapies and diagnostics.
(1) The naked mole
rat (NMR) (Heterocephalus glaber) is of interest to aging and
cancer researchers due to its maximum lifespan exceeding 30 years
and having no reported cases of cancer. Previously, our lab
identified a novel tumor suppressor mechanism wherein NMR
fibroblasts display resistance to malignant transformation due to
contact inhibition hypersensitivity, termed early contact
inhibition (E.C.I.). The external and upstream signals for NMR
cells to undergo E.C.I. are not known. Here, I show signaling of
E.C.I. is induced by NMR cells secreting high molecular weight
(HMW) (>6,000 kDa) hyaluronic acid (HA), an extracellular
glycosaminoglycan, through upregulation of HA synthase 2. HMW-HA,
interacting with NMR specific forms of the transmembrane HA
receptor CD44, induced the signaling cascade needed to initiate ECI
and resistance to malignant transformation by sequestering the NF2
tumor suppressor in a growth inhibitory state. Also, an abundance
of HA in NMR tissues suggests a cytoprotective barrier due to
HMW-HA protecting cells from oxidative and mechanical stress. I
conclude that NMR’s longevity and cancer resistance are due, in
part, to their utilization of HMW-HA.
(2) Rad51, involved in
homologous recombination, is overexpressed in the majority of human
cancers, and its expression correlates with a poor prognosis. Using
cell culture and xenograft systems, I show the differential
expression of Rad51 can be exploited in Rad51 promoter-based cancer
therapy and diagnostic systems. Placing a reporter ORF downstream
of the Rad51 promoter displayed an average difference in promoter
activity between cancer and normal cells of over 800-fold. A
construct comprised of the Rad51 promoter driven expression of the
diphtheria toxin A gene (pRad51-DTA) destroyed a variety of human
cancer cell lines, with minimal to no toxicity in noncancerous
human cells. Delivery of Rad51 promoter-based constructs in vivo
using jetPEI nanoparticles was used to visualize and treat mice
with human cervical cancer xenografts. pRad51-Luc, a construct
containing firefly luciferase under the Rad51 promoter, was used
for tumor detection and imaging. Mice with cancer, but not without,
displayed strong bioluminescence, indicating tumor specific in vivo
activity of pRad51-Luc. Treatment with pRad51-DTA decreased tumor
mass of subcutaneous (SC) and intraperitoneal (IP) tumors by 6-fold
and 4-fold, respectively, along with a 23-fold reduction of…
Subjects/Keywords: Cancer; Gene Therapy; Naked Mole Rat
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APA (6th Edition):
Hine, Christopher M.; Gorbunova, V. (2011). Defying and Defeating Cancer: Hyaluronic Acid and the
Rad51 Promoter. (Doctoral Dissertation). University of Rochester. Retrieved from http://hdl.handle.net/1802/15811
Chicago Manual of Style (16th Edition):
Hine, Christopher M.; Gorbunova, Vera. “Defying and Defeating Cancer: Hyaluronic Acid and the
Rad51 Promoter.” 2011. Doctoral Dissertation, University of Rochester. Accessed April 22, 2021.
http://hdl.handle.net/1802/15811.
MLA Handbook (7th Edition):
Hine, Christopher M.; Gorbunova, Vera. “Defying and Defeating Cancer: Hyaluronic Acid and the
Rad51 Promoter.” 2011. Web. 22 Apr 2021.
Vancouver:
Hine, Christopher M.; Gorbunova V. Defying and Defeating Cancer: Hyaluronic Acid and the
Rad51 Promoter. [Internet] [Doctoral dissertation]. University of Rochester; 2011. [cited 2021 Apr 22].
Available from: http://hdl.handle.net/1802/15811.
Council of Science Editors:
Hine, Christopher M.; Gorbunova V. Defying and Defeating Cancer: Hyaluronic Acid and the
Rad51 Promoter. [Doctoral Dissertation]. University of Rochester; 2011. Available from: http://hdl.handle.net/1802/15811
University of Cambridge
2.
Hadi, Fazal.
Understanding the Cancer Resistance Mechanisms of the Naked Mole-Rat.
Degree: PhD, 2020, University of Cambridge
URL: https://www.repository.cam.ac.uk/handle/1810/303395
► The naked mole-rat (NMR, Heterocephalus glaber) is a highly unusual mammal: eusocial, cold-blooded and with remarkable resistance to hypoxia, hypercapnia and acid-induced pain. Furthermore, NMRs…
(more)
▼ The naked mole-rat (NMR, Heterocephalus glaber) is a highly unusual mammal: eusocial, cold-blooded and with remarkable resistance to hypoxia, hypercapnia and acid-induced pain. Furthermore, NMRs are exceptionally long-lived and extremely cancer resistant. Few studies have attempted to explain the reason behind the NMR’s cancer resistance, but most prominently Tian et al. have reported that NMR cells are resistant to tumourigenesis induced by SV40 large T antigen and oncogenic RAS (SV40LT-HRASG12V), a combination of oncogenes sufficient to transform mouse and rat cells. Additionally, Tian et al. have reported that high-molecular weight hyaluronan (HMW-HA) mediates the NMR’s cancer resistance and inhibition of HMW-HA signalling render NMR cells susceptible to transformation by SV40LT-HRASG12V.
With the publication of the NMR genome and advances in CRISPR-Cas9 gene editing, I set out to systematically interrogate the NMR genome through a genome-wide CRISPR screen to identify the genes responsible for its cancer resistance. My approach was based on Tian et al.’s finding that the NMR cells are not transformed by SV40LT-HRASG12V unless a further gene is perturbed. Therefore, I aimed to knockout every gene in the NMR genome (a set of ~55,000 predicted genes) in NMR cells expressing SV40LT-HRASG12V and test them for anchorage-independent growth, a hallmark of cancer cells. I, therefore, developed a novel CRISPR gRNA library containing 81116 gRNAs targeting the entire NMR genome. Next, I developed a set of lentiviral vectors to deliver SV40LT-HRASG12V into NMR cells. Using these vectors, I generated 106 different cell lines from 5 different tissues of 11 NMRs and found that, contrary to previous reports, NMR cells are transformed by expression of SV40LT-HRASG12V. Using transcriptomic analysis, I show that both NMR and mouse cells undergo similar gene expression changes in response to introduction of SV40LT-HRASG12V.
Taken together, this thesis challenges previous findings of the field and points to non-cell autonomous processes such as the immune system and cellular microenvironment as key players behind NMR’s cancer resistance. Exploring these new avenues could have profound effect on our understanding of tumour biology.
Subjects/Keywords: Naked Mole-Rat; Cancer Resistance; CRISPR-Cas9
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APA (6th Edition):
Hadi, F. (2020). Understanding the Cancer Resistance Mechanisms of the Naked Mole-Rat. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/303395
Chicago Manual of Style (16th Edition):
Hadi, Fazal. “Understanding the Cancer Resistance Mechanisms of the Naked Mole-Rat.” 2020. Doctoral Dissertation, University of Cambridge. Accessed April 22, 2021.
https://www.repository.cam.ac.uk/handle/1810/303395.
MLA Handbook (7th Edition):
Hadi, Fazal. “Understanding the Cancer Resistance Mechanisms of the Naked Mole-Rat.” 2020. Web. 22 Apr 2021.
Vancouver:
Hadi F. Understanding the Cancer Resistance Mechanisms of the Naked Mole-Rat. [Internet] [Doctoral dissertation]. University of Cambridge; 2020. [cited 2021 Apr 22].
Available from: https://www.repository.cam.ac.uk/handle/1810/303395.
Council of Science Editors:
Hadi F. Understanding the Cancer Resistance Mechanisms of the Naked Mole-Rat. [Doctoral Dissertation]. University of Cambridge; 2020. Available from: https://www.repository.cam.ac.uk/handle/1810/303395
University of Illinois – Chicago
3.
LaVinka, Pamela C.
Trigeminal Nociception in the African Naked Mole-Rat: The Acid Test.
Degree: 2012, University of Illinois – Chicago
URL: http://hdl.handle.net/10027/9248
► Acidosis in the skin triggers activation of pain pathways, and behaviors indicative of pain in vertebrates. The exception is the naked mole-rat, the only known…
(more)
▼ Acidosis in the skin triggers activation of pain pathways, and behaviors indicative of pain in vertebrates. The exception is the
naked mole-
rat, the only known vertebrate to show physiological and behavioral insensitivity to acid pain in the skin. The goal of the present study was to determine behavioral and physiological responses of this species to airborne acidic fumes, which would be expected to affect the trigeminal pain pathway in other species. Behaviorally,
naked mole-rats did not avoid fumes from moderately high concentrations of acetic acid (10 and 20%), and c Fos labeling showed no increase in activity in the trigeminal and vagal nuclei. In contrast, these concentrations triggered behavioral aversion and increased Fos activity in other laboratory rodents. For a very high concentration of acetic acid (50%),
naked mole-rats showed significant avoidance behavior and increased Fos labeling in the vagus nucleus. However, there was no increase in trigeminal labeling, and in fact, activity significantly decreased. This pattern is opposite of that associated with another irritant, ammonia fumes, which elicited an increase in trigeminal but not vagal Fos labeling, and no behavioral avoidance. Behavioral avoidance of acidic fumes, but no increased labeling in the trigeminal pain nucleus is consistent with the notion of adaptations to blunt acid pain, which would be advantageous for
naked mole-rats as they normally live under chronically high levels of acidosis-inducing CO2.
Advisors/Committee Members: Murphy, Don (advisor), Park, Thomas J. (committee member), Malchow, Robert (committee member), Wirtshafter, Dave (committee member), Ragazzino, Michael (committee member).
Subjects/Keywords: naked mole-rat; pain; trigeminal; c Fos
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APA (6th Edition):
LaVinka, P. C. (2012). Trigeminal Nociception in the African Naked Mole-Rat: The Acid Test. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/9248
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
LaVinka, Pamela C. “Trigeminal Nociception in the African Naked Mole-Rat: The Acid Test.” 2012. Thesis, University of Illinois – Chicago. Accessed April 22, 2021.
http://hdl.handle.net/10027/9248.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
LaVinka, Pamela C. “Trigeminal Nociception in the African Naked Mole-Rat: The Acid Test.” 2012. Web. 22 Apr 2021.
Vancouver:
LaVinka PC. Trigeminal Nociception in the African Naked Mole-Rat: The Acid Test. [Internet] [Thesis]. University of Illinois – Chicago; 2012. [cited 2021 Apr 22].
Available from: http://hdl.handle.net/10027/9248.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
LaVinka PC. Trigeminal Nociception in the African Naked Mole-Rat: The Acid Test. [Thesis]. University of Illinois – Chicago; 2012. Available from: http://hdl.handle.net/10027/9248
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Toronto
4.
Collins, Troy.
Adult Neurogenesis in Naked Mole-Rats: Time Course of Cell Maturation and The Effects of Social Novelty.
Degree: 2019, University of Toronto
URL: http://hdl.handle.net/1807/102898
► Naked mole-rats (NMR) are one of the only eusocial mammalian species. Their complex social structure makes them unique for the study of interactions between adult…
(more)
▼ Naked mole-rats (NMR) are one of the only eusocial mammalian species. Their complex social structure makes them unique for the study of interactions between adult neurogenesis and social behavior. I explored the time course of maturation of newly born cells in neurogenic regions of the adult NMR brain. I found that most new NMR cells mature by 5 months. To test whether cell proliferation is related to processing social cues, I examined the effects of a novel social stimulus in two subordinate subcastes. Soldiers produced more new cells in the subventricular zone than workers. NMRs exposed to a novel social stimulus were more aggressive and investigated their counterpart more than those in a familiar pair. Soldiers in novel pairs, but not workers, spent more time sniffing the genitals of their counterpart. Thus, caste and social context play a role in the rate of proliferation and the behavior of NMRs.
M.Sc.
2020-11-19 00:00:00
Advisors/Committee Members: Holmes, Melissa M, Cell and Systems Biology.
Subjects/Keywords: naked mole-rat; neurogenesis; social behavior; 0317
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APA ·
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APA (6th Edition):
Collins, T. (2019). Adult Neurogenesis in Naked Mole-Rats: Time Course of Cell Maturation and The Effects of Social Novelty. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/102898
Chicago Manual of Style (16th Edition):
Collins, Troy. “Adult Neurogenesis in Naked Mole-Rats: Time Course of Cell Maturation and The Effects of Social Novelty.” 2019. Masters Thesis, University of Toronto. Accessed April 22, 2021.
http://hdl.handle.net/1807/102898.
MLA Handbook (7th Edition):
Collins, Troy. “Adult Neurogenesis in Naked Mole-Rats: Time Course of Cell Maturation and The Effects of Social Novelty.” 2019. Web. 22 Apr 2021.
Vancouver:
Collins T. Adult Neurogenesis in Naked Mole-Rats: Time Course of Cell Maturation and The Effects of Social Novelty. [Internet] [Masters thesis]. University of Toronto; 2019. [cited 2021 Apr 22].
Available from: http://hdl.handle.net/1807/102898.
Council of Science Editors:
Collins T. Adult Neurogenesis in Naked Mole-Rats: Time Course of Cell Maturation and The Effects of Social Novelty. [Masters Thesis]. University of Toronto; 2019. Available from: http://hdl.handle.net/1807/102898
University of Rochester
5.
Azpurua, Jorge E. (1984 - ); Seluanov, Andrei.
Comparative biology of longevity: the molecular
mechanisms promoting long lifespan in the naked mole-rat
(Heterocephalus glaber).
Degree: PhD, 2013, University of Rochester
URL: http://hdl.handle.net/1802/27225
► This thesis addresses the proximal molecular mechanisms responsible for the longevity of the naked mole-rat (Heterocephalus glaber, hereafter NMR) compared to the short-lived laboratory mouse.…
(more)
▼ This thesis addresses the proximal molecular
mechanisms responsible for the
longevity of the naked mole-rat
(Heterocephalus glaber, hereafter NMR) compared
to the short-lived
laboratory mouse. One major contributor to short lifespan in the
mouse is susceptibility to oncogenesis relative to other mammals.
In contrast, the
NMR is highly resistant to neoplasia. I describe
work done in collaboration with Dr.
Christopher Hine and Xiao Tian
showing that high molecular weight hyaluronan is an
important
anti-tumor defense in the NMR. We use both in vitro and in vivo
approaches to show that hyaluronan loss is necessary for
transformation of NMR
fibroblasts.
Additionally, I characterized
the NMR INK4a/b tumor suppressor locus. Normally,
INK4a/b produces
three tumor-suppressor proteins: p16INK4a,
p15INK4b, and ARF. I
show that the NMR
additionally produces a splice variant that joins E1 from INK4b to
E2 from INK4a. I confirmed expression of this variant in tissue
culture and in vivo. I
demonstrate that it is upregulated by
hyaluronan and downregulated after
hyaluronidase treatment.
Overexpression of the variant confirmed it had biological
activity
similar to p16INK4a, which may contribute to
NMR tumor resistance and
longevity.
NMR cells are exceptionally
slow-growing compared to other rodent cell lines, even
in optimal
(physiological) tissue culture conditions. We detected an unusual
ribosomal break in the NMR, and this led us to assay ribosomal
translation rate. I
constructed translational fidelity reporter
plasmids, which were used to assay the
accuracy of the NMR
ribosome. We found that NMR cells had a similar overall
translation rate as mouse cells, but their translational fidelity
was four-fold higher.
We propose that higher translational
fidelity contributes to the lifespan of the NMR.
Lastly, I
compared the expression of IGF1R protein (a conserved regulator of
lifespan from worms to humans) in a variety of tissues from all
rodents available in
our lab. I identified a strong inverse
correlation between the level of expression of
IGF1R in the brain
tissue of rodents and their maximum lifespan. This correlation
was
maintained after phylogenetic correction using independent
contrasts. This
supports the idea that neuroendocrine signaling
contributes to maximum lifespan of
long-lived
rodents.
Subjects/Keywords: Heterocephalus; Hyaluronan; IGF-1R; Naked mole-rat; P16; Translation fidelity
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Manager
APA (6th Edition):
Azpurua, Jorge E. (1984 - ); Seluanov, A. (2013). Comparative biology of longevity: the molecular
mechanisms promoting long lifespan in the naked mole-rat
(Heterocephalus glaber). (Doctoral Dissertation). University of Rochester. Retrieved from http://hdl.handle.net/1802/27225
Chicago Manual of Style (16th Edition):
Azpurua, Jorge E. (1984 - ); Seluanov, Andrei. “Comparative biology of longevity: the molecular
mechanisms promoting long lifespan in the naked mole-rat
(Heterocephalus glaber).” 2013. Doctoral Dissertation, University of Rochester. Accessed April 22, 2021.
http://hdl.handle.net/1802/27225.
MLA Handbook (7th Edition):
Azpurua, Jorge E. (1984 - ); Seluanov, Andrei. “Comparative biology of longevity: the molecular
mechanisms promoting long lifespan in the naked mole-rat
(Heterocephalus glaber).” 2013. Web. 22 Apr 2021.
Vancouver:
Azpurua, Jorge E. (1984 - ); Seluanov A. Comparative biology of longevity: the molecular
mechanisms promoting long lifespan in the naked mole-rat
(Heterocephalus glaber). [Internet] [Doctoral dissertation]. University of Rochester; 2013. [cited 2021 Apr 22].
Available from: http://hdl.handle.net/1802/27225.
Council of Science Editors:
Azpurua, Jorge E. (1984 - ); Seluanov A. Comparative biology of longevity: the molecular
mechanisms promoting long lifespan in the naked mole-rat
(Heterocephalus glaber). [Doctoral Dissertation]. University of Rochester; 2013. Available from: http://hdl.handle.net/1802/27225
University of Toronto
6.
Toor, Ilapreet.
Characterizing the Putative Disperser Morph in Naked Mole-Rats.
Degree: 2017, University of Toronto
URL: http://hdl.handle.net/1807/79237
► Naked mole-rats are eusocial mammals; their hierarchy consists of one breeding female, 1 to 3 male consorts, and their reproductively suppressed siblings and offspring. A…
(more)
▼ Naked mole-rats are eusocial mammals; their hierarchy consists of one breeding female, 1 to 3 male consorts, and their reproductively suppressed siblings and offspring. A potential â disperserâ subcaste has been suggested. The purpose of the current study was to better characterize the putative disperser morph. I hypothesized that dispersers and workers would exhibit different in-colony and out-colony behaviors, colony characteristics would affect the presence of dispersers, and dispersers would reproduce quicker than workers. The results found that naked mole-rats of both sexes consistently dispersed. Male dispersers and workers had minimal differences in in-colony behaviors and both preferred familiar colony odor. Queen aggression increased presence of female dispersers only. Dispersers were heavier and fatter than workers. Dispersers and workers produced litters at a similar rate to each other. These results suggest that dispersers may not be a separate subcaste, but rather a subset of the existing workers with increased exploratory behavior.
M.Sc.
Advisors/Committee Members: Holmes, Melissa M, Ecology and Evolutionary Biology.
Subjects/Keywords: Behavior; Disperser Morph; Naked mole-rat; Subcastes; 0602
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APA (6th Edition):
Toor, I. (2017). Characterizing the Putative Disperser Morph in Naked Mole-Rats. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/79237
Chicago Manual of Style (16th Edition):
Toor, Ilapreet. “Characterizing the Putative Disperser Morph in Naked Mole-Rats.” 2017. Masters Thesis, University of Toronto. Accessed April 22, 2021.
http://hdl.handle.net/1807/79237.
MLA Handbook (7th Edition):
Toor, Ilapreet. “Characterizing the Putative Disperser Morph in Naked Mole-Rats.” 2017. Web. 22 Apr 2021.
Vancouver:
Toor I. Characterizing the Putative Disperser Morph in Naked Mole-Rats. [Internet] [Masters thesis]. University of Toronto; 2017. [cited 2021 Apr 22].
Available from: http://hdl.handle.net/1807/79237.
Council of Science Editors:
Toor I. Characterizing the Putative Disperser Morph in Naked Mole-Rats. [Masters Thesis]. University of Toronto; 2017. Available from: http://hdl.handle.net/1807/79237
University of Illinois – Chicago
7.
Osborne, Hilary Beth.
Hunger, Hiding, and Habitat: Observations and Game Theoretical Explorations of Foraging and Burrowing.
Degree: 2016, University of Illinois – Chicago
URL: http://hdl.handle.net/10027/21533
► These five chapters cover a wide variety of subjects. First, we explored naked mole-rat foraging patterns via a laboratory study measuring how naked mole-rats allocated…
(more)
▼ These five chapters cover a wide variety of subjects. First, we explored
naked mole-
rat foraging patterns via a laboratory study measuring how
naked mole-rats allocated their foraging efforts when searching for hidden treats. Contrary to our expectations of cooperative foraging, they appear to forage only for themselves, and may even hide information about food patches from one another:
naked mole-
rat society is apparently despotic rather than cooperative. Second, we traveled to Mapungubwe National Park, South Africa, to look at the distribution of aardvark-dug burrows, how quickly they appear and disappear, and how frequently they are used. We confirmed what many suspected: these burrows are distributed in a clumped pattern, and while they appear and collapse all the time, some last for many years and all have a good chance of being visited by some animal at any time. We also monitored dozens of burrows with camera traps to determine the identity of these burrow-users. Warthogs are king. This may reflect species abundance, as warthogs are quite numerous at Mapungubwe. The distribution of these burrows indicates that for aardvarks they are likely feeding digs, reflecting the clumped distribution of ant and termite nests. We then considered what actually happens when an aardvark tears into a termite mound. The termites can run away, send soldiers to defend the mound, or both. We created and explored a generalized model of how this additional decline, a form of behavioral resource depression, affects the time the predator spends in the patch and how much food they actually consume. We also took the first step toward combining this with the slow renewal of resources within a patch and how a finite number of these patches can affect the predator’s long-term harvest. Finally, we modeled how hunger may affect a forager and its predator. Inspired by the well-studied gerbil–owl foraging game, we developed a model which shows that the likelihood a predator will hunt increases with the forager’s hunger level.
Advisors/Committee Members: Brown, Joel S (advisor), Ale, Som B. (committee member), Berger-Wolf, Tanya (committee member), Park, Thomas J (committee member), Whelan, Christopher J (committee member), Brown, Joel S (chair).
Subjects/Keywords: burrow; foraging; game theory; aardvark; naked mole-rat; hunger
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APA (6th Edition):
Osborne, H. B. (2016). Hunger, Hiding, and Habitat: Observations and Game Theoretical Explorations of Foraging and Burrowing. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/21533
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Osborne, Hilary Beth. “Hunger, Hiding, and Habitat: Observations and Game Theoretical Explorations of Foraging and Burrowing.” 2016. Thesis, University of Illinois – Chicago. Accessed April 22, 2021.
http://hdl.handle.net/10027/21533.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Osborne, Hilary Beth. “Hunger, Hiding, and Habitat: Observations and Game Theoretical Explorations of Foraging and Burrowing.” 2016. Web. 22 Apr 2021.
Vancouver:
Osborne HB. Hunger, Hiding, and Habitat: Observations and Game Theoretical Explorations of Foraging and Burrowing. [Internet] [Thesis]. University of Illinois – Chicago; 2016. [cited 2021 Apr 22].
Available from: http://hdl.handle.net/10027/21533.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Osborne HB. Hunger, Hiding, and Habitat: Observations and Game Theoretical Explorations of Foraging and Burrowing. [Thesis]. University of Illinois – Chicago; 2016. Available from: http://hdl.handle.net/10027/21533
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Toronto
8.
Mooney, Skyler James.
The Oxytocinergic Regulation of Social Behaviour and the Identification of Task Specialization in the Eusocial Naked Mole-rat.
Degree: PhD, 2015, University of Toronto
URL: http://hdl.handle.net/1807/71558
► The naked mole-rat exhibits one of the most remarkable reproductive skews among mammals. This species consists of a breeding queen and her male consorts in…
(more)
▼ The
naked mole-
rat exhibits one of the most remarkable reproductive skews among mammals. This species consists of a breeding queen and her male consorts in addition to their reproductively suppressed offspring and/or kin. The differences between reproductive and non-reproductive members of a colony play out in a number of neural and endocrine measures, including neurons involved in the production of the hormone oxytocin.
In other rodents, oxytocin is involved in a number of social behaviours including social recognition, partner preference formation, parental care and alloparental pup care. However, the role of this peptide in the regulation of social behaviours in the
naked mole-
rat remains unknown. This avenue of research is particularly exciting due to the high level of sociality that the
naked mole-
rat exhibits. The current set of experiments were undertaken to try and understand where and how oxytocin might act to influence social behaviour in this species with a special emphasis on the non-reproductive subordinates.
Chapter 1 explored whether breeders and subordinates differ in their distributions/densities of oxytocin receptors. Autoradiographical analysis was conducted with a radiolabelled oxytocin agonist. Chapter 2 looked at whether peripheral injections of oxytocin would change the behaviour of subordinates. Experiment 1 of this chapter looked at in-colony behaviour and experiment 2 looked at behaviour directed towards a single colony mate or a small group of newborn pups from the home colony. Chapter 3 is the development of a method to explore the central effects of oxytocin manipulation. Chapter 4 explored whether central oxytocin antagonism or agonism affects behaviour directed towards a colony mate, an unfamiliar
mole-
rat from another colony, or a small group of pups from the home colony.
The non-reproductive subordinate caste of
naked mole-rats shows incredibly variable rates of labour related tasks and defense against unfamiliar
mole-rats from another colony. Chapter 5 looks at whether this variability represents stable individual differences and whether ecological demands of the colony are capable of altering a normally stable behavioural profile.
Advisors/Committee Members: Holmes, Melissa M, Psychology.
Subjects/Keywords: Eusociality; Naked Mole-rat; Oxytocin; Polyethism; Prosociality; Task-switching; 0317
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APA (6th Edition):
Mooney, S. J. (2015). The Oxytocinergic Regulation of Social Behaviour and the Identification of Task Specialization in the Eusocial Naked Mole-rat. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/71558
Chicago Manual of Style (16th Edition):
Mooney, Skyler James. “The Oxytocinergic Regulation of Social Behaviour and the Identification of Task Specialization in the Eusocial Naked Mole-rat.” 2015. Doctoral Dissertation, University of Toronto. Accessed April 22, 2021.
http://hdl.handle.net/1807/71558.
MLA Handbook (7th Edition):
Mooney, Skyler James. “The Oxytocinergic Regulation of Social Behaviour and the Identification of Task Specialization in the Eusocial Naked Mole-rat.” 2015. Web. 22 Apr 2021.
Vancouver:
Mooney SJ. The Oxytocinergic Regulation of Social Behaviour and the Identification of Task Specialization in the Eusocial Naked Mole-rat. [Internet] [Doctoral dissertation]. University of Toronto; 2015. [cited 2021 Apr 22].
Available from: http://hdl.handle.net/1807/71558.
Council of Science Editors:
Mooney SJ. The Oxytocinergic Regulation of Social Behaviour and the Identification of Task Specialization in the Eusocial Naked Mole-rat. [Doctoral Dissertation]. University of Toronto; 2015. Available from: http://hdl.handle.net/1807/71558
University of Toronto
9.
Hathaway, Georgia Alexandra.
Oxytocin, Aggression, and Neural Activity in the Naked Mole-rat.
Degree: 2014, University of Toronto
URL: http://hdl.handle.net/1807/70193
► The neuropeptide Oxytocin (OT) is involved in social bonding and pro-social behaviour, however its role in aggression and social status is less clear. The naked…
(more)
▼ The neuropeptide Oxytocin (OT) is involved in social bonding and pro-social behaviour, however its role in aggression and social status is less clear. The naked mole-rat (Heterocephalus glaber) provides a unique model organism in which to study the effects of OT, exhibiting a social hierarchy that emphasizes certain roles for castes within the colony: soldiers defend colonies against outsiders and workers cooperate within the colony. Here, we wanted to determine whether OT is associated with defensive aggression in soldiers. We compared the behaviour of workers and soldiers using a modified resident-intruder paradigm and quantified neural activity of OT neurons in the hypothalamic paraventricular nucleus (PVN) using immunohistochemistry. Our results show that soldiers were more aggressive than workers when paired with an unfamiliar animal. However, preliminary analyses of the PVN suggest that workers have greater OT neural activity than soldiers, implying that OT is not associated with aggression in soldiers.
M.A.
Advisors/Committee Members: Holmes, Melissa M, Psychology.
Subjects/Keywords: Aggression; Naked Mole-Rat; Neural Activity; Oxytocin; Paraventricular Nucleus; Social Status; 0349
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APA (6th Edition):
Hathaway, G. A. (2014). Oxytocin, Aggression, and Neural Activity in the Naked Mole-rat. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/70193
Chicago Manual of Style (16th Edition):
Hathaway, Georgia Alexandra. “Oxytocin, Aggression, and Neural Activity in the Naked Mole-rat.” 2014. Masters Thesis, University of Toronto. Accessed April 22, 2021.
http://hdl.handle.net/1807/70193.
MLA Handbook (7th Edition):
Hathaway, Georgia Alexandra. “Oxytocin, Aggression, and Neural Activity in the Naked Mole-rat.” 2014. Web. 22 Apr 2021.
Vancouver:
Hathaway GA. Oxytocin, Aggression, and Neural Activity in the Naked Mole-rat. [Internet] [Masters thesis]. University of Toronto; 2014. [cited 2021 Apr 22].
Available from: http://hdl.handle.net/1807/70193.
Council of Science Editors:
Hathaway GA. Oxytocin, Aggression, and Neural Activity in the Naked Mole-rat. [Masters Thesis]. University of Toronto; 2014. Available from: http://hdl.handle.net/1807/70193
University of Toronto
10.
Mooney, Skyler.
Oxytocin-immunoreactive Neurons in the Paraventricular Nucleus of the Hypothalamus in Hetercephalus glaber: A Quantitative Analysis.
Degree: 2011, University of Toronto
URL: http://hdl.handle.net/1807/31347
► The naked mole-rat (Heterocephalus glaber) demonstrates a strict social and reproductive hierarchy. Oxytocin (OXT) is a peptide hormone that acts both peripherally and centrally in…
(more)
▼ The naked mole-rat (Heterocephalus glaber) demonstrates a strict social and reproductive hierarchy. Oxytocin (OXT) is a peptide hormone that acts both peripherally and centrally in the regulation of a number of sexual and social behaviours. The main area of central production of this peptide is the paraventricular nucleus of the hypothalamus (PVN). The present study characterized differences that exist in OXT neurons in this region. Breeders and subordinates from established colonies were sacrificed and brains were processed for OXT-immunoreactivity. Four further groups of paired animals underwent various social and hormonal manipulations (opposite-sex paired, same sex-paired, opposite-sex/gonadectomised paired, opposite-sex/vasectomized paired) and were also used for analysis. Results showed that subordinate naked mole-rats had significantly more OXT-immunoreactive neurons in the PVN than either breeders or paired animals that had been gonadectomised. However, no differences were found on measures of OXT cell volume. Possible functional significance of these differences is discussed.
MAST
Advisors/Committee Members: Homes, Melissa, Psychology.
Subjects/Keywords: oxytocin; naked mole-rat; paraventricular nucleus of the hypothalamus; Hetercephalus glaber; 0349
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CSE |
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APA (6th Edition):
Mooney, S. (2011). Oxytocin-immunoreactive Neurons in the Paraventricular Nucleus of the Hypothalamus in Hetercephalus glaber: A Quantitative Analysis. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/31347
Chicago Manual of Style (16th Edition):
Mooney, Skyler. “Oxytocin-immunoreactive Neurons in the Paraventricular Nucleus of the Hypothalamus in Hetercephalus glaber: A Quantitative Analysis.” 2011. Masters Thesis, University of Toronto. Accessed April 22, 2021.
http://hdl.handle.net/1807/31347.
MLA Handbook (7th Edition):
Mooney, Skyler. “Oxytocin-immunoreactive Neurons in the Paraventricular Nucleus of the Hypothalamus in Hetercephalus glaber: A Quantitative Analysis.” 2011. Web. 22 Apr 2021.
Vancouver:
Mooney S. Oxytocin-immunoreactive Neurons in the Paraventricular Nucleus of the Hypothalamus in Hetercephalus glaber: A Quantitative Analysis. [Internet] [Masters thesis]. University of Toronto; 2011. [cited 2021 Apr 22].
Available from: http://hdl.handle.net/1807/31347.
Council of Science Editors:
Mooney S. Oxytocin-immunoreactive Neurons in the Paraventricular Nucleus of the Hypothalamus in Hetercephalus glaber: A Quantitative Analysis. [Masters Thesis]. University of Toronto; 2011. Available from: http://hdl.handle.net/1807/31347
University of Toronto
11.
Poulson, Sandra Jaramillo.
Characterizing Neuropathic Pain in the Naked Mole-Rat (Heterocephalus glaber).
Degree: 2018, University of Toronto
URL: http://hdl.handle.net/1807/91621
► The nociceptive system of the African naked mole-rat (Heterocephalus glaber) contains unique adaptations that make the species insensitive to skin pain from some chemical stimuli.…
(more)
▼ The nociceptive system of the African naked mole-rat (Heterocephalus glaber) contains unique adaptations that make the species insensitive to skin pain from some chemical stimuli. Sensitivity to thermal and mechanical stimuli are hallmark symptoms of chronic pain following nerve injury. Upon damage, a cascade of molecular signals is released and contribute to chronic pain. To determine whether naked mole-rats develop long-lasting sensitivity, I adapted the spared nerve injury rodent model and applied the model to subordinate males and females of soldier and worker status. I then measured behavioral responses to mild and strong mechanical stimuli and a mild cold stimulus. Hypersensitivity to both mild and strong mechanical stimuli were comparable between naked mole-rats and mice following nerve injury. Unlike mice, naked mole-rats showed no reaction to mild cold after nerve injury. This non-response to mild cold could arise from unusual connectivity or atypical receptor expression or function.
Le système nociceptif du rat-taupe africain nu (Heterocephalus glaber) contient des adaptations uniques qui rendent l’espèce insensible aux douleurs de la peau causées par certains stimuli chimiques. La sensibilité aux stimuli thermiques et mécaniques est un symptôme caractéristique de la douleur chronique consécutive à une lésion nerveuse. Pour déterminer si les rats-taupes nus développent une sensibilité durable, j'ai adapté le modèle de rongeur lésé au nerf épargné et appliqué le modèle aux subordonnés mâles et femelles ayant le statut de soldat et de travailleur. J'ai ensuite mesuré les réponses comportementales à des stimuli mécaniques légers et forts et à un stimulus froid léger. L'hypersensibilité à des stimuli mécaniques légers et puissants était comparable chez les rats-taupes nus et les souris après une lésion nerveuse. Contrairement aux souris, les rats-taupes nus ne présentaient aucune réaction au froid léger après une lésion nerveuse.
M.A.
Advisors/Committee Members: Martin, Loren J, Holmes, Melissa M, Psychology.
Subjects/Keywords: naked mole-rat; neuropathic pain; nociception; rodent behavior; social status; TRP receptors; 0602
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Poulson, S. J. (2018). Characterizing Neuropathic Pain in the Naked Mole-Rat (Heterocephalus glaber). (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/91621
Chicago Manual of Style (16th Edition):
Poulson, Sandra Jaramillo. “Characterizing Neuropathic Pain in the Naked Mole-Rat (Heterocephalus glaber).” 2018. Masters Thesis, University of Toronto. Accessed April 22, 2021.
http://hdl.handle.net/1807/91621.
MLA Handbook (7th Edition):
Poulson, Sandra Jaramillo. “Characterizing Neuropathic Pain in the Naked Mole-Rat (Heterocephalus glaber).” 2018. Web. 22 Apr 2021.
Vancouver:
Poulson SJ. Characterizing Neuropathic Pain in the Naked Mole-Rat (Heterocephalus glaber). [Internet] [Masters thesis]. University of Toronto; 2018. [cited 2021 Apr 22].
Available from: http://hdl.handle.net/1807/91621.
Council of Science Editors:
Poulson SJ. Characterizing Neuropathic Pain in the Naked Mole-Rat (Heterocephalus glaber). [Masters Thesis]. University of Toronto; 2018. Available from: http://hdl.handle.net/1807/91621
University of Kentucky
12.
Triplett, Judy C.
PROTEOMICS AND PHOSPHOPROTEOMICS OF BRAIN: (1) ANALYSES OF THE PINK1 KNOCKOUT MODEL OF PARKINSON DISEASE; (2) INSIGHTS INTO THE PROGRESSION OF ALZHEIMER DISEASE; AND (3) THE NAKED MOLE-RAT MODEL OF SALUBRIOUS AGING.
Degree: 2015, University of Kentucky
URL: https://uknowledge.uky.edu/chemistry_etds/49
► Proteomics is the field of science in which proteins produced by an organism (the proteome) are identified. The level of a particular protein can vary…
(more)
▼ Proteomics is the field of science in which proteins produced by an organism (the proteome) are identified. The level of a particular protein can vary with time and the influence of cellular stressors. The study of phosphoproteomics is vital because tyrosine, serine and threonine phosphorylation modulate protein structure and function and is a crucial regulator of cellular signaling pathways. Dysregulation of protein and phosphorylation levels has been reported in multiple neurodegenerative disorders including Parkinson disease (PD) and Alzheimer disease (AD).
PINK1 is a mitochondrial serine/threonine kinase that polices mitochondrial integrity. Mutations in this protein are associated with familial early-onset PD. PD is characterized by accumulated Lewy bodies, largely composed of aggregated alpha-synuclein, and progressive dopaminergic neuronal degeneration in the substantia nigra. In this dissertation study, proteomics identified differences in protein expression and protein phosphorylation levels in the brains of PINK1 knockout mice. The observed changes suggest that perturbed metabolism, diminished proteostasis, decreased neuronal plasticity, and aberrant cellular signaling are implicated in familial PD pathogenesis.
AD is characterized by senile plaques, neurofibrillary tangles and synapse loss. Previously, multiple AD brain proteins were reported from our laboratory as abnormally phosphorylated, indicating that deregulated phosphorylation may play a key role in AD pathogenesis. In this dissertation study, quantitative phosphoproteomic analyses were conducted on the inferior parietal lobule from three different clinical stages of AD, i.e., late-stage AD, amnestic mild cognitive impairment (MCI) and preclinical AD (PCAD). The differential phosphoproteins identified provide insights into underlying mechanisms promoting the preservation of memory in PCAD with expansive AD pathology, while uncovering early aberrant phosphorylation events in MCI that conceivably may be involved in the progressive cognitive decline leading to dementia.
Aging is a primary risk factor for development of neurodegenerative disorders, including AD and PD. The naked mole-rat (NMR), which can live for 32 years, is currently under investigation to gain insights into extending human lifespan and healthspan. In this dissertation research, age-related alterations of the brain proteome and phosphoproteome of the NMR were identified, revealing key proteins involved in neuronal plasticity, energy metabolism, autophagy, and the ubiquitin-proteasome system that may contribute to salubrious longevity.
Subjects/Keywords: Proteomics; Phosphoproteomics; Parkinson Disease; Alzheimer Disease; Naked Mole-Rat; Medicine and Health Sciences
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APA (6th Edition):
Triplett, J. C. (2015). PROTEOMICS AND PHOSPHOPROTEOMICS OF BRAIN: (1) ANALYSES OF THE PINK1 KNOCKOUT MODEL OF PARKINSON DISEASE; (2) INSIGHTS INTO THE PROGRESSION OF ALZHEIMER DISEASE; AND (3) THE NAKED MOLE-RAT MODEL OF SALUBRIOUS AGING. (Doctoral Dissertation). University of Kentucky. Retrieved from https://uknowledge.uky.edu/chemistry_etds/49
Chicago Manual of Style (16th Edition):
Triplett, Judy C. “PROTEOMICS AND PHOSPHOPROTEOMICS OF BRAIN: (1) ANALYSES OF THE PINK1 KNOCKOUT MODEL OF PARKINSON DISEASE; (2) INSIGHTS INTO THE PROGRESSION OF ALZHEIMER DISEASE; AND (3) THE NAKED MOLE-RAT MODEL OF SALUBRIOUS AGING.” 2015. Doctoral Dissertation, University of Kentucky. Accessed April 22, 2021.
https://uknowledge.uky.edu/chemistry_etds/49.
MLA Handbook (7th Edition):
Triplett, Judy C. “PROTEOMICS AND PHOSPHOPROTEOMICS OF BRAIN: (1) ANALYSES OF THE PINK1 KNOCKOUT MODEL OF PARKINSON DISEASE; (2) INSIGHTS INTO THE PROGRESSION OF ALZHEIMER DISEASE; AND (3) THE NAKED MOLE-RAT MODEL OF SALUBRIOUS AGING.” 2015. Web. 22 Apr 2021.
Vancouver:
Triplett JC. PROTEOMICS AND PHOSPHOPROTEOMICS OF BRAIN: (1) ANALYSES OF THE PINK1 KNOCKOUT MODEL OF PARKINSON DISEASE; (2) INSIGHTS INTO THE PROGRESSION OF ALZHEIMER DISEASE; AND (3) THE NAKED MOLE-RAT MODEL OF SALUBRIOUS AGING. [Internet] [Doctoral dissertation]. University of Kentucky; 2015. [cited 2021 Apr 22].
Available from: https://uknowledge.uky.edu/chemistry_etds/49.
Council of Science Editors:
Triplett JC. PROTEOMICS AND PHOSPHOPROTEOMICS OF BRAIN: (1) ANALYSES OF THE PINK1 KNOCKOUT MODEL OF PARKINSON DISEASE; (2) INSIGHTS INTO THE PROGRESSION OF ALZHEIMER DISEASE; AND (3) THE NAKED MOLE-RAT MODEL OF SALUBRIOUS AGING. [Doctoral Dissertation]. University of Kentucky; 2015. Available from: https://uknowledge.uky.edu/chemistry_etds/49
13.
Seney, Marianne Louise.
Effects of Sex and Social Status on Neuromuscular Differentiation in the Eusocial Naked Mole-Rat (Heterocephalus Glaber).
Degree: PhD, Neuroscience and Behavior, 2009, U of Massachusetts : PhD
URL: https://scholarworks.umass.edu/open_access_dissertations/136
► Naked mole-rats live in large colonies and exhibit a strict reproductive hierarchy. Each colony has 1 breeding female and 1-3 breeding males; all other…
(more)
▼ Naked mole-rats live in large colonies and exhibit a strict reproductive hierarchy. Each colony has 1 breeding female and 1-3 breeding males; all other individuals are non-reproductive subordinates. Subordinates show a remarkable lack of sex differences in behavior and anatomy, but can become reproductive if removed from the colony. The striated perineal muscles and their innervating motoneurons, which are sexually dimorphic in all other mammals examined, are not dimorphic in subordinate
naked mole-rats. Here I asked whether sexual differentiation of this neuromuscular system occurs when subordinates become breeders. Sex differences in perineal motoneurons were not observed, regardless of social status. To my surprise counts of motoneurons in Onuf’s nucleus were increased in breeders of both sexes. This was accompanied by a reciprocal decrease in cells in Onuf’s nucleus that were characterized by small soma size. The neuronal changes correlate with increased perineal muscle volumes in breeders. Although not exhibiting typical motoneuron morphology, some small cells fit a neurochemical or functional definition of a motoneuron. I propose that small cells are recruited to the pool of large Onuf’s nucleus motoneurons when subordinate
naked mole-rats become breeders. I then looked at
naked mole-rats of varying status (subordinates, paired animals that have never reproduced, intact breeders, and gonadectomized breeders) to determine which cues elicit changes in perineal muscles and small cells in Onuf’s nucleus. I found that pairing is sufficient to cause decreases in the population of small cells in Onuf’s nucleus, while production of litters is necessary for increasing in perineal muscle size. The gonads were not necessary to maintain changes in small cells or perineal muscles. I hypothesized that the lack of sex differences in
naked mole-rats might be related to their unusual social structure. To test this, I compared the genitalia and perineal muscles in three African
mole-
rat species: the
naked mole-
rat, the solitary silvery
mole-
rat, and the Damaraland
mole-
rat, a species considered to be eusocial, but with less reproductive skew than
naked mole-rats. My findings support a relationship between social structure, mating system, and sexual differentiation.
Advisors/Committee Members: Nancy G. Forger, Geert J. de Vries, Bruce D. Goldman.
Subjects/Keywords: eusocial; naked mole-rat; sex difference; Neurosciences
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APA (6th Edition):
Seney, M. L. (2009). Effects of Sex and Social Status on Neuromuscular Differentiation in the Eusocial Naked Mole-Rat (Heterocephalus Glaber). (Doctoral Dissertation). U of Massachusetts : PhD. Retrieved from https://scholarworks.umass.edu/open_access_dissertations/136
Chicago Manual of Style (16th Edition):
Seney, Marianne Louise. “Effects of Sex and Social Status on Neuromuscular Differentiation in the Eusocial Naked Mole-Rat (Heterocephalus Glaber).” 2009. Doctoral Dissertation, U of Massachusetts : PhD. Accessed April 22, 2021.
https://scholarworks.umass.edu/open_access_dissertations/136.
MLA Handbook (7th Edition):
Seney, Marianne Louise. “Effects of Sex and Social Status on Neuromuscular Differentiation in the Eusocial Naked Mole-Rat (Heterocephalus Glaber).” 2009. Web. 22 Apr 2021.
Vancouver:
Seney ML. Effects of Sex and Social Status on Neuromuscular Differentiation in the Eusocial Naked Mole-Rat (Heterocephalus Glaber). [Internet] [Doctoral dissertation]. U of Massachusetts : PhD; 2009. [cited 2021 Apr 22].
Available from: https://scholarworks.umass.edu/open_access_dissertations/136.
Council of Science Editors:
Seney ML. Effects of Sex and Social Status on Neuromuscular Differentiation in the Eusocial Naked Mole-Rat (Heterocephalus Glaber). [Doctoral Dissertation]. U of Massachusetts : PhD; 2009. Available from: https://scholarworks.umass.edu/open_access_dissertations/136
University of Michigan
14.
Braude, Stanton.
The behavior and demographics of the naked mole-rat, Heterocephalus glaber.
Degree: PhD, Zoology, 1991, University of Michigan
URL: http://hdl.handle.net/2027.42/128677
► The question of how eusociality evolved in insects has been a major question for evolutionary biology since Darwin. Recently, a mammal, the naked mole-rat, was…
(more)
▼ The question of how eusociality evolved in insects has been a major question for evolutionary biology since Darwin. Recently, a mammal, the
naked mole-
rat, was discovered also to have queens and functionally sterile workers. From 1986 to 1990 I trapped, marked, and studied the demography and behavior of a wild population of over 2000
naked mole-rats in Meru National Park, Kenya. Sex ratios in wild colonies were male biased. However, higher mortality among small males resulted in female biased sex ratios among the larger members of the colony. Few phenotypic differences were found between the sexes and the reasons for higher mortality among small males were not discovered. Despite unusually high life spans reported for
naked mole-rats in captivity (16 years or greater), attrition in wild colonies sometimes exceeded 60 percent in a single year. Such mortality is compensated at the colony level by extremely high reproductive rates. Mortality of queens was much lower than that of workers. Attrition in wild colonies may be due in large part to mortality, during colony maintenance and defense or failed attempts to disperse. Although others have argued that
naked mole-rats only form new colonies by fissioning of existing colonies, I present evidence that pairs of
mole-rats can found new colonies. Individual
naked mole-rats also move about on the soil surface at times, perhaps in efforts to disperse. Discovery of eusociality in two new animal taxa in the past 15 years (Homoptera and Rodentia), suggests that the selective forces which have led to the evolution of eusociality in animals may have led to similar division of reproductive labor in the plant kingdom. Suggestions are made as to where to look for analogues of social behavior in the plant kingdom.
Advisors/Committee Members: Alexander, Richard D. (advisor).
Subjects/Keywords: Behavior; Demographics; Glaber; Heterocephalus; Kenya; Mole; Naked; Rat
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APA ·
Chicago ·
MLA ·
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APA (6th Edition):
Braude, S. (1991). The behavior and demographics of the naked mole-rat, Heterocephalus glaber. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/128677
Chicago Manual of Style (16th Edition):
Braude, Stanton. “The behavior and demographics of the naked mole-rat, Heterocephalus glaber.” 1991. Doctoral Dissertation, University of Michigan. Accessed April 22, 2021.
http://hdl.handle.net/2027.42/128677.
MLA Handbook (7th Edition):
Braude, Stanton. “The behavior and demographics of the naked mole-rat, Heterocephalus glaber.” 1991. Web. 22 Apr 2021.
Vancouver:
Braude S. The behavior and demographics of the naked mole-rat, Heterocephalus glaber. [Internet] [Doctoral dissertation]. University of Michigan; 1991. [cited 2021 Apr 22].
Available from: http://hdl.handle.net/2027.42/128677.
Council of Science Editors:
Braude S. The behavior and demographics of the naked mole-rat, Heterocephalus glaber. [Doctoral Dissertation]. University of Michigan; 1991. Available from: http://hdl.handle.net/2027.42/128677
15.
Peterson, Bethany L.
Extreme Resistance to Oxygen Deprivation in Brain Tissue from the Naked Mole-Rat.
Degree: 2012, University of Illinois – Chicago
URL: http://hdl.handle.net/10027/8659
► The naked mole-rat lives in large colonies living completely underground, a very unique way of life. This leads to an environment where the air is…
(more)
▼ The
naked mole-
rat lives in large colonies living completely underground, a very unique way of life. This leads to an environment where the air is low in oxygen and high in carbon dioxide. Adaptations in blood and metabolism have been previously reported in the
naked mole-
rat that help it survive these conditions. My study is aimed at specifically examining the tolerance to low oxygen (hypoxia) in the brain of this unusual species. My working hypothesis was that
naked mole-rats retain neonatal protective characteristics against hypoxia into adulthood.
First we exposed whole animals to no oxygen (anoxia) to see how long they survived. A group of
naked mole-rats was exposed for around 6 minutes and still recovered once put back in room air. This is remarkable when compared to mice, which only survived around 45 seconds and did not recover. We then measured the levels of ATP in the brains of adult
naked mole-rats compared to adult mice and neonatal mice. This is important because ATP is the energy of the brain and oxygen is needed for its synthesis. We found that ATP stores in adult
naked mole-
rat brain depleted slower than in adult mouse brain, however, it was not as slow as in neonatal mouse brain.
Next, since many hypoxia-tolerant model systems are able to prevent an increase in internal calcium that leads to cell death during hypoxia, we wanted to establish if
naked mole-rats could prevent this as well. We determined that in hippocampal brain slices from
naked mole-rats the increase in internal calcium was significantly reduced compared to both neonatal and weanling mice.
Lastly, we wanted to find out if the adult
naked mole-
rat brain retained more of the NMDA receptor subunit NR2D into adulthood compared to adult mouse brain. This subtype closes during hypoxia and is usually expressed more in neonatal mammals than in adults. We revealed that adult
naked mole-rats do have a higher proportion of the NR2D subunit in adulthood compared to mice.
These finding lead us to conclude that
naked mole-rats are retaining neonatal protective characteristics against hypoxia.
Advisors/Committee Members: Murphy, Alvin D. (advisor), Park, Thomas J. (committee member), Larson, John R. (committee member), Fall, Christopher P. (committee member), Leonard, John P. (committee member).
Subjects/Keywords: naked mole-rat; hypoxia; neonatal; brain tissue
…NMDA
N- methyl-D-aspartate
NMDAR
N- methyl-D-aspartate receptor
NMR
Naked mole-rat
OGD… …x29;
PKA
Protein kinase A
ROS
Reactive oxygen species
x
SUMMARY
The naked mole-rat… …oxygen is needed for its synthesis. We found that ATP stores in adult naked mole-rat
brain… …mice.
Lastly, we wanted to find out if the adult naked mole-rat brain retained more of the… …I examine the naked mole-rat, which lives in a chronically low oxygen environment.
I…
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APA (6th Edition):
Peterson, B. L. (2012). Extreme Resistance to Oxygen Deprivation in Brain Tissue from the Naked Mole-Rat. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/8659
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Peterson, Bethany L. “Extreme Resistance to Oxygen Deprivation in Brain Tissue from the Naked Mole-Rat.” 2012. Thesis, University of Illinois – Chicago. Accessed April 22, 2021.
http://hdl.handle.net/10027/8659.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Peterson, Bethany L. “Extreme Resistance to Oxygen Deprivation in Brain Tissue from the Naked Mole-Rat.” 2012. Web. 22 Apr 2021.
Vancouver:
Peterson BL. Extreme Resistance to Oxygen Deprivation in Brain Tissue from the Naked Mole-Rat. [Internet] [Thesis]. University of Illinois – Chicago; 2012. [cited 2021 Apr 22].
Available from: http://hdl.handle.net/10027/8659.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Peterson BL. Extreme Resistance to Oxygen Deprivation in Brain Tissue from the Naked Mole-Rat. [Thesis]. University of Illinois – Chicago; 2012. Available from: http://hdl.handle.net/10027/8659
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Michigan
16.
Ciszek, Deborah.
Behavior of the naked mole -rat (Heterocephalus glaber), with emphasis on factors related to the attainment of breeding status.
Degree: PhD, Zoology, 2001, University of Michigan
URL: http://hdl.handle.net/2027.42/130399
► I explored the evolution of eusociality through the study of naked mole-rats, small African rodents that are highly social: numerous non-breeding workers cooperate to raise…
(more)
▼ I explored the evolution of eusociality through the study of
naked mole-rats, small African rodents that are highly social: numerous non-breeding workers cooperate to raise the offspring of a single female, usually their mother. She breeds with a small number of males; the remaining colony members perform construction, maintenance, and defense of the colony. Though physiologically capable of reproduction, individuals delay doing so, such that many never directly reproduce. I investigated some of the factors underlying this extreme form of cooperation, especially traits correlated with future breeding status. The study utilized 200 captive individually-marked
mole-rats, comprising 14 colonies. The chapters take up various topics related to
naked mole-
rat behavior. In chapter one I describe a tendency of the animals to hold a chip of wood behind their incisors when they dig, and discuss alternative hypotheses explaining the behavior. For chapter two I measured change over time in skin pigmentation, and found that breeders lose coloration faster than do non-breeders. Chapters three and four comprise a study of colony formation. I tested for correlations between future breeding status and four categories of behavior: eating and provisioning of food to colonymates under conditions of both abundant and restricted food availability, tendency to exit the colony, defense of the colony against foreign conspecifics, and time budgets for typical daily behavior. There was no evidence that animals that would eventually become breeders behaved differently in their natal colonies than did animals that remained non-breeders. I took several measures of physical size and body fat content, and found that only weight significantly predicted eventual breeding status. Mating pairs in experimental colonies consisted of unfamiliar distant kin (despite the equivalent presence of familiar close kin) which is surprising given that high levels of genetic similarity within colonies had suggested that close inbreeding was typical. Chapter five describes a rare case of colony-wide aggression in this normally highly cooperative species. Finally, chapter six synthesizes current evolutionary and medical approaches to understanding senescence, with ramifications for
naked mole-rats and vertebrates in general.
Advisors/Committee Members: Alexander, Richard D. (advisor).
Subjects/Keywords: Attainment; Behavior; Breeding; Emphasis; Eusociality; Factors; Heterocephalus Glaber; Naked Mole-rat; Related; Status
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APA (6th Edition):
Ciszek, D. (2001). Behavior of the naked mole -rat (Heterocephalus glaber), with emphasis on factors related to the attainment of breeding status. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/130399
Chicago Manual of Style (16th Edition):
Ciszek, Deborah. “Behavior of the naked mole -rat (Heterocephalus glaber), with emphasis on factors related to the attainment of breeding status.” 2001. Doctoral Dissertation, University of Michigan. Accessed April 22, 2021.
http://hdl.handle.net/2027.42/130399.
MLA Handbook (7th Edition):
Ciszek, Deborah. “Behavior of the naked mole -rat (Heterocephalus glaber), with emphasis on factors related to the attainment of breeding status.” 2001. Web. 22 Apr 2021.
Vancouver:
Ciszek D. Behavior of the naked mole -rat (Heterocephalus glaber), with emphasis on factors related to the attainment of breeding status. [Internet] [Doctoral dissertation]. University of Michigan; 2001. [cited 2021 Apr 22].
Available from: http://hdl.handle.net/2027.42/130399.
Council of Science Editors:
Ciszek D. Behavior of the naked mole -rat (Heterocephalus glaber), with emphasis on factors related to the attainment of breeding status. [Doctoral Dissertation]. University of Michigan; 2001. Available from: http://hdl.handle.net/2027.42/130399
University of Illinois – Chicago
17.
Barone, Catherine M.
Maturation of the Structure and Function of the African Naked Mole-Rat Inner Ear.
Degree: 2019, University of Illinois – Chicago
URL: http://hdl.handle.net/10027/23704
► African naked mole-rats (Heterocephalus glaber) are a highly vocal and long-lived subterranean species with elevated auditory thresholds, poor frequency selectivity, and a limited ability to…
(more)
▼ African
naked mole-rats (Heterocephalus glaber) are a highly vocal and long-lived subterranean species with elevated auditory thresholds, poor frequency selectivity, and a limited ability to localize sound compared to other rodents. The poor hearing in
naked mole-rats (NMRs) suggests an under-developed auditory system, specifically the cochlea, which is responsible for encoding and relaying auditory signals to the brain. To examine
the patterns of innervation and physiology of the NMR cochlea techniques included: immunofluorescence and quantitative image analysis, physiological assessments of hair cell and auditory nerve function, and structural examination of the organ of Corti, the sensory epithelium in the cochlea. NMRs were compared to mice (Mus musculus), gerbils (Meriones unguiculatus), and Damaraland
mole-rats (Fukomys damarensis), another subterranean rodent. The results of the study indicate that in comparison to mice and gerbils, there are alterations in afferent and efferent innervation as well as in the patterns of developmental refinement in both
naked and Damaraland
mole-rats. However, there were noticeable differences in these alterations between
naked and Damaraland
mole-rats. In both
naked and Damaraland
mole-rats, inner hair cell afferent ribbon density was reduced, whereas outer hair cell afferent ribbon density was increased.
Naked and Damaraland
mole-rats also showed reduced lateral and medial efferent terminal density. Developmentally, NMRs showed reduced and prolonged postnatal reorganization of afferent and efferent innervation. However, Damaraland
mole-rats showed no evidence of postnatal reorganization. A restricted cochlear amplifier and altered organization of the organ of Corti and outer hair cell morphology compared to other rodents was also observed. Overall, these results provide more insight into the mechanisms that enhance frequency sensitivity and sound localization, maturation and aging of the auditory system, as well as the evolutionary adaptations occurring in response to subterranean environments.
Advisors/Committee Members: Park, Thomas (advisor), Alford, Simon (committee member), Pyott, Sonja (committee member), Lauer, Amanda (committee member), Lasek, Amy (chair).
Subjects/Keywords: naked mole-rat; auditory; cochlea; inner ear; inner and outer hair cells; presynaptic afferent ribbons; BK channels; lateral and medial efferent olivocochlear innervation; development
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APA ·
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MLA ·
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CSE |
Export
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APA (6th Edition):
Barone, C. M. (2019). Maturation of the Structure and Function of the African Naked Mole-Rat Inner Ear. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/23704
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Barone, Catherine M. “Maturation of the Structure and Function of the African Naked Mole-Rat Inner Ear.” 2019. Thesis, University of Illinois – Chicago. Accessed April 22, 2021.
http://hdl.handle.net/10027/23704.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Barone, Catherine M. “Maturation of the Structure and Function of the African Naked Mole-Rat Inner Ear.” 2019. Web. 22 Apr 2021.
Vancouver:
Barone CM. Maturation of the Structure and Function of the African Naked Mole-Rat Inner Ear. [Internet] [Thesis]. University of Illinois – Chicago; 2019. [cited 2021 Apr 22].
Available from: http://hdl.handle.net/10027/23704.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Barone CM. Maturation of the Structure and Function of the African Naked Mole-Rat Inner Ear. [Thesis]. University of Illinois – Chicago; 2019. Available from: http://hdl.handle.net/10027/23704
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Western Ontario
18.
Patel, Nisha.
A bioinformatics analysis of contributors to false discovery for a mouse genotyping array.
Degree: 2018, University of Western Ontario
URL: https://ir.lib.uwo.ca/etd/5647
► Microarray experiments employing massively-parallel hybridization are valuable for the study of genetic variation, however, errors during hybridization and limitations of single-species design must be considered…
(more)
▼ Microarray experiments employing massively-parallel hybridization are valuable for the study of genetic variation, however, errors during hybridization and limitations of single-species design must be considered for use within and across species. The Mouse Diversity Genotyping Array (MDGA) is a low cost, high-resolution microarray with probes that bind to target DNA for variant detection. Errors associated with probe design and incomplete protein removal from target DNA lead to false discovery and thus necessitate examination of probe suitability and target DNA availability. Bioinformatics methods were used to carry out confirmation of probe annotations, assessment of DNA accessibility for hybridization to probes, and prediction of the theoretical ability of MDGA probes to hybridize cross-species to naked mole-rat genomic DNA. The results are a filtered probe list demonstrated to reduce false discovery, a suggested approach to assess biases arising from protein-bound DNA, and predictions for cross-species application of the MDGA to naked mole-rat samples.
Subjects/Keywords: Mouse Diversity Genotyping Array; Mus musculus; hybridization; microarray probes; copy number variants; single nucleotide polymorphism; SNP genotyping; cross-species hybridization; naked mole-rat; Biology; Genetics and Genomics
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APA ·
Chicago ·
MLA ·
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CSE |
Export
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Manager
APA (6th Edition):
Patel, N. (2018). A bioinformatics analysis of contributors to false discovery for a mouse genotyping array. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/5647
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Patel, Nisha. “A bioinformatics analysis of contributors to false discovery for a mouse genotyping array.” 2018. Thesis, University of Western Ontario. Accessed April 22, 2021.
https://ir.lib.uwo.ca/etd/5647.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Patel, Nisha. “A bioinformatics analysis of contributors to false discovery for a mouse genotyping array.” 2018. Web. 22 Apr 2021.
Vancouver:
Patel N. A bioinformatics analysis of contributors to false discovery for a mouse genotyping array. [Internet] [Thesis]. University of Western Ontario; 2018. [cited 2021 Apr 22].
Available from: https://ir.lib.uwo.ca/etd/5647.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Patel N. A bioinformatics analysis of contributors to false discovery for a mouse genotyping array. [Thesis]. University of Western Ontario; 2018. Available from: https://ir.lib.uwo.ca/etd/5647
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
19.
Cousteils, Katelyn.
Role of High Molecular Weight Hyaluronan in Ultraviolet B Light-Induced Transformation.
Degree: 2017, University of Western Ontario
URL: https://ir.lib.uwo.ca/etd/5111
► Keratinocyte carcinomas (KCs) are the most common cancers globally. Ultraviolet light is the key risk factor for these cancers but sunscreen has proven ineffective in…
(more)
▼ Keratinocyte carcinomas (KCs) are the most common cancers globally. Ultraviolet light is the key risk factor for these cancers but sunscreen has proven ineffective in their prevention, indicating a need for new prophylactic agents. Chronic elevation of high molecular weight (HMW) tissue hyaluronan (HA) in skin is linked to tumor resistance in the naked mole rat. To directly assess the role of this polysaccharide in resistance to keratinocyte tumors, a HMW HA phosphatidylethanolamine (HA-PE) formulation that penetrates skin and accumulates as coats around keratinocytes was prepared. The tumor resistance properties of the HA-PE formulation were tested in a mouse model of UVB-induced KC (Hr-/- Ptch+/-). HA-PE significantly reduced the number of visible lesions per mouse compared to the control groups. None of these lesions were neoplastic; in contrast, approximately 20% (7/34) of lesions were neoplastic in control groups. These results show that HA-PE protects against UVB-induced keratinocyte transformation, suggesting that HA-PE may be an effective preventative therapy for KC.
Subjects/Keywords: cancer; hyaluronan; inflammation; keratinocyte; naked mole rat; phosphatidylethanolamine; skin; ultraviolet; Cancer Biology
…rat
cancer resistance to the accumulation of hyaluronan [106]. Naked mole rat skin… …x5D;.
Naked mole rat HAS2 has two amino acid substitutions relative to the otherwise well… …degrading
enzyme hyaluronidase 2 (HYAL2) in naked mole rat skin fibroblasts led to… …the cancerresistant, long-lived naked mole rat links HA to skin tumor resistance.
11
1.6… …x5D;.
Given the tumor resistance in the naked mole rat due to increased HA and our ability…
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Cousteils, K. (2017). Role of High Molecular Weight Hyaluronan in Ultraviolet B Light-Induced Transformation. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/5111
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Cousteils, Katelyn. “Role of High Molecular Weight Hyaluronan in Ultraviolet B Light-Induced Transformation.” 2017. Thesis, University of Western Ontario. Accessed April 22, 2021.
https://ir.lib.uwo.ca/etd/5111.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Cousteils, Katelyn. “Role of High Molecular Weight Hyaluronan in Ultraviolet B Light-Induced Transformation.” 2017. Web. 22 Apr 2021.
Vancouver:
Cousteils K. Role of High Molecular Weight Hyaluronan in Ultraviolet B Light-Induced Transformation. [Internet] [Thesis]. University of Western Ontario; 2017. [cited 2021 Apr 22].
Available from: https://ir.lib.uwo.ca/etd/5111.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Cousteils K. Role of High Molecular Weight Hyaluronan in Ultraviolet B Light-Induced Transformation. [Thesis]. University of Western Ontario; 2017. Available from: https://ir.lib.uwo.ca/etd/5111
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Illinois – Chicago
20.
Blass, Gregory R.
Extreme Resistance to Hypercapnia-Induced Pulmonary Edema of the African Naked Mole-Rat.
Degree: 2014, University of Illinois – Chicago
URL: http://hdl.handle.net/10027/18916
► The African naked-mole rat lives chronically in a hypercapnia due to many individuals living together in small enclosed burrows. At extreme hypercapnia, pulmonary edema is…
(more)
▼ The African
naked-
mole rat lives chronically in a hypercapnia due to many individuals living together in small enclosed burrows. At extreme hypercapnia, pulmonary edema is induced in many terrestrial mammals. The present study aim was to examine the resistance
naked mole-rats have to the physiological effects of hypercapnia and determine the mechanism of hypercapnia-induced pulmonary edema. We found extreme hypercapnia was unable to induce pulmonary edema in
naked mole-rats. Previously, their cutaneous c-fibers were found to be insensitive to acid stimuli and this was thought to be an adaptation to hypercapnia acidosis. Pulmonary c-fibers release the peptide substance P that can induce pulmonary edema. A related peptide, hemokinin-1, has the same endogenous receptor, neurokinin 1, and is also present within the lungs. We predicted that
naked mole-rats in response to hypercapnia would have attenuated release of substance P and hemokinin-1 within their lungs. Surprisingly,
naked mole-rats had no detectable amount of substance P or hemokinin-1 in lavage fluid at control or after 30% CO2 exposure. We further studied the function of pulmonary c-fiber acid sensitivity in hypercapnia-induced pulmonary edema. Mice that lack channels expressed by c-fibers that are acid sensitive, TrpV1 and ASIC3, were exposed to extreme hypercapnia. We found that the absence of these channels had no effect on hypercapnia-induced pulmonary edema. We also used mice that lacked substance P gene, tac1, expression and found significant increased edema that was counter to our original hypothesis. The volatile anesthetic isoflurane has previously been found to have anti-inflammatory effect on pulmonary induced inflammation. We used isoflurane in conjunction with acute 30% CO2 exposure in mice. We found that isoflurane greatly attenuated hypercapnia-induced edema and abolished the increased release of substance P and hemokinin-1 in lung lavage fluid of wild-type mice. These results indicated that hypercapnia-induced pulmonary edema may not be mediated by the acid-sensitivity of pulmonary c-fibers but may involve hemokinin-1. For the first time, isoflurane was found to attenuate hypercapnia-induced pulmonary edema. The absence of detectable substance P and hemokinin-1 within the
naked mole-
rat lungs may be part of their adaptation for living in hypercapnia.
Advisors/Committee Members: Malchow, Robert P. (advisor), Park, Thomas J. (committee member), Murphy, Alvin D. (committee member), Leonard, John P. (committee member), Minshall, Richard D. (committee member).
Subjects/Keywords: substance P; hypercapnia; pulmonary edema; c-fiber; acidosis; hemokinin-1; naked mole-rat; Tachykinin 1 Gene (tac1); Neurokinin 1 Receptor (NK1r); Transient Receptor Potential Vanilloid 1 Channel (TrpV1); Acid-sensing Ion Channel (ASIC3); isoflurane; anesthetic; respiration; pulmonary inflammation; lavage
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APA ·
Chicago ·
MLA ·
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CSE |
Export
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Manager
APA (6th Edition):
Blass, G. R. (2014). Extreme Resistance to Hypercapnia-Induced Pulmonary Edema of the African Naked Mole-Rat. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/18916
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Blass, Gregory R. “Extreme Resistance to Hypercapnia-Induced Pulmonary Edema of the African Naked Mole-Rat.” 2014. Thesis, University of Illinois – Chicago. Accessed April 22, 2021.
http://hdl.handle.net/10027/18916.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Blass, Gregory R. “Extreme Resistance to Hypercapnia-Induced Pulmonary Edema of the African Naked Mole-Rat.” 2014. Web. 22 Apr 2021.
Vancouver:
Blass GR. Extreme Resistance to Hypercapnia-Induced Pulmonary Edema of the African Naked Mole-Rat. [Internet] [Thesis]. University of Illinois – Chicago; 2014. [cited 2021 Apr 22].
Available from: http://hdl.handle.net/10027/18916.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Blass GR. Extreme Resistance to Hypercapnia-Induced Pulmonary Edema of the African Naked Mole-Rat. [Thesis]. University of Illinois – Chicago; 2014. Available from: http://hdl.handle.net/10027/18916
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
21.
Mongillo, Daniel Luigi.
Differential Effects of Chronic Fluoxetine on the Behaviour of Dominant and Subordinate Naked Mole-rats.
Degree: 2013, University of Toronto
URL: http://hdl.handle.net/1807/43261
► Naked mole-rats are eusocial rodents that live in subterranean colonies with a strict reproductive and social hierarchy. Breeders are socially dominant and other colony members…
(more)
▼ Naked mole-rats are eusocial rodents that live in subterranean colonies with a strict reproductive and social hierarchy. Breeders are socially dominant and other colony members are non-reproductive subordinates. The effects of manipulating the serotonergic system on aggression are well studied in many species, but not in eusocial rodents like the naked mole-rat. For the current study, the effects of fluoxetine hydrochloride (FLX) on status-specific behaviours of subordinates (Experiment 1) and queens (Experiment 2) were evaluated both in-colony and in a social-pairing paradigm to investigate how the serotonergic system influences aggression in this species. In accordance with our main hypothesis, chronic treatment of FLX attenuated the frequency and duration of aggression in queens, but not subordinates, when paired with an unfamiliar conspecific. Further exploration of pharmacological manipulation on status-specific behaviours of this eusocial species may elucidate the neurobiological mechanisms underlying their unique and rigid social hierarchy.
MAST
Advisors/Committee Members: Holmes, Melissa M., Psychology.
Subjects/Keywords: 5-hydroxytryptamine (5-HT); Fluoxetine hydrochloride (Prozac); Naked mole-rat; Social behaviour; Social status; 0349; 0384; 0620
…the naked mole-rat. In the following sections, eusociality
and its relevance to the naked… …of the naked mole-rat will be discussed with focus on the
9
current study’s… …naked mole-rat colony consists of a breeding female and one to
three breeding males; all other… …of behavioural differences
that are contingent upon the social status of the naked mole-rat… …certain extent, define the social role or status in a naked mole-rat colony
may be altered by…
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
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Manager
APA (6th Edition):
Mongillo, D. L. (2013). Differential Effects of Chronic Fluoxetine on the Behaviour of Dominant and Subordinate Naked Mole-rats. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/43261
Chicago Manual of Style (16th Edition):
Mongillo, Daniel Luigi. “Differential Effects of Chronic Fluoxetine on the Behaviour of Dominant and Subordinate Naked Mole-rats.” 2013. Masters Thesis, University of Toronto. Accessed April 22, 2021.
http://hdl.handle.net/1807/43261.
MLA Handbook (7th Edition):
Mongillo, Daniel Luigi. “Differential Effects of Chronic Fluoxetine on the Behaviour of Dominant and Subordinate Naked Mole-rats.” 2013. Web. 22 Apr 2021.
Vancouver:
Mongillo DL. Differential Effects of Chronic Fluoxetine on the Behaviour of Dominant and Subordinate Naked Mole-rats. [Internet] [Masters thesis]. University of Toronto; 2013. [cited 2021 Apr 22].
Available from: http://hdl.handle.net/1807/43261.
Council of Science Editors:
Mongillo DL. Differential Effects of Chronic Fluoxetine on the Behaviour of Dominant and Subordinate Naked Mole-rats. [Masters Thesis]. University of Toronto; 2013. Available from: http://hdl.handle.net/1807/43261
. 
Open Access Theses and Dissertations
