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You searched for subject:(multimode sensing). Showing records 1 – 2 of 2 total matches.

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Florida International University

1. Panday, Namuna. Scanning Ion Conductance Microscopy for Single Cell Imaging and Analysis.

Degree: PhD, Physics, 2017, Florida International University

Most biological experiments are performed on an ensemble of cells under the assumption that all cells are identical. However, recent evidence from single cells studies reveals that this assumption is incorrect. Individual cells within the same generation may differ dramatically, and these differences have important consequences for the health and function of the entire living body. I have used Scanning Ion Conductance Microscopy (SICM) for imaging and analysis of topographical change of single cell membrane, which is difficult to be revealed by optical microscopes. Morphological change in the fixed and live HeLa cell membrane during endocytosis of conjugated polymer nanoparticles was studied. Results demonstrated SICM is a powerful tool to study the interaction between nanoparticle and cell membrane during internalization of nanoparticles through the membrane. This research can improve our fundamental understanding of cellular behavior and will be helpful for drug delivery applications. Based on conventional SICM, we have developed a novel method to simultaneous map the topography and potential distributions of the single living cells membranes. At the first step, multifunctional nanopipettes (nanopore/nanoelectrode) have been fabricated and characterized. To demonstrate the potential sensing capability and understand the mechanism, I measured the ionic current and local electric potential change during translocation of 40 nm charged gold nanoparticles. Our results reveal the capability of the multifunctional probe for the highly sensitive detection of the ionic current and local electrical potential changes during the translocation of the charged entity through the nanopore. From the potential change, we revealed the dynamic assembly of GNPs before entering the nanopore. The experimental results are also nicely explained by the finite element method based numerical simulation results. At the second step, I have measured the surface potential of living cell membrane at selected locations. Very recently, I have obtained results to show that we can map the extracellular membrane potential distribution of the complicated living cell membrane with sub-micron spatial resolution.This new imaging technique can help biologist to explore the extracellular potential distribution of varieties of cells quantitatively.These studies will have impacts on several biomedical applications such as regenerative repair and cancer treatment. Advisors/Committee Members: Jin He, Wenzhi Li, Prem P Chapagain, Joong-Ho Moon.

Subjects/Keywords: SPM; SICM; Live Cell Imaging; Single cell Study; Extracellular potentail imaging; nanoelectrode; nanopipette; nanopore; nanoparticle accumulation; potential sensing; multimode sensing; Biological and Chemical Physics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Panday, N. (2017). Scanning Ion Conductance Microscopy for Single Cell Imaging and Analysis. (Doctoral Dissertation). Florida International University. Retrieved from http://digitalcommons.fiu.edu/etd/3477 ; 10.25148/etd.FIDC001918 ; FIDC001918

Chicago Manual of Style (16th Edition):

Panday, Namuna. “Scanning Ion Conductance Microscopy for Single Cell Imaging and Analysis.” 2017. Doctoral Dissertation, Florida International University. Accessed October 20, 2019. http://digitalcommons.fiu.edu/etd/3477 ; 10.25148/etd.FIDC001918 ; FIDC001918.

MLA Handbook (7th Edition):

Panday, Namuna. “Scanning Ion Conductance Microscopy for Single Cell Imaging and Analysis.” 2017. Web. 20 Oct 2019.

Vancouver:

Panday N. Scanning Ion Conductance Microscopy for Single Cell Imaging and Analysis. [Internet] [Doctoral dissertation]. Florida International University; 2017. [cited 2019 Oct 20]. Available from: http://digitalcommons.fiu.edu/etd/3477 ; 10.25148/etd.FIDC001918 ; FIDC001918.

Council of Science Editors:

Panday N. Scanning Ion Conductance Microscopy for Single Cell Imaging and Analysis. [Doctoral Dissertation]. Florida International University; 2017. Available from: http://digitalcommons.fiu.edu/etd/3477 ; 10.25148/etd.FIDC001918 ; FIDC001918

2. Thomas Lee, S; Dr.Nampoori,V P N. Design. Fabrication and Characterization of Fiber Optic Sensors for Physical and Chemical Applications.

Degree: 2003, Cochin University of Science and Technology

Advent of lasers together with the advancement in fiber optics technology has revolutionized the sensor technology. Advancement in the telemetric applications of optical fiber based measurements is an added bonus. The present thesis describes variety of fiber based sensors using techniques like micro bending, long period grating and evanescent waves. Sensors to measure various physical and chemical parameters are described in this thesis.

International School of Photonics, Cochin University of Science and Technology

Subjects/Keywords: Fiber Optics; Dielectric interfaces; Evanescent wave; Single Mode Fibers; Bandwidth; Fiber optic communication; Attenuation; Dispersion; Fiber optic Sensors; Polarimetric sensors; Spectrophotometry; Sensitive fiber optic pH sensors; Sol-gel glass; Chemical sensing; Microbent optical fibers; Interferometric weight; Displacement sensor; pollution monitoring sensors; Multimode fibers; Grating Fabrication Techniques

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Thomas Lee, S. D. N. P. N. (2003). Design. Fabrication and Characterization of Fiber Optic Sensors for Physical and Chemical Applications. (Thesis). Cochin University of Science and Technology. Retrieved from http://dyuthi.cusat.ac.in/purl/2117

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Thomas Lee, S; Dr Nampoori,V P N. “Design. Fabrication and Characterization of Fiber Optic Sensors for Physical and Chemical Applications.” 2003. Thesis, Cochin University of Science and Technology. Accessed October 20, 2019. http://dyuthi.cusat.ac.in/purl/2117.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Thomas Lee, S; Dr Nampoori,V P N. “Design. Fabrication and Characterization of Fiber Optic Sensors for Physical and Chemical Applications.” 2003. Web. 20 Oct 2019.

Vancouver:

Thomas Lee SDNPN. Design. Fabrication and Characterization of Fiber Optic Sensors for Physical and Chemical Applications. [Internet] [Thesis]. Cochin University of Science and Technology; 2003. [cited 2019 Oct 20]. Available from: http://dyuthi.cusat.ac.in/purl/2117.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Thomas Lee SDNPN. Design. Fabrication and Characterization of Fiber Optic Sensors for Physical and Chemical Applications. [Thesis]. Cochin University of Science and Technology; 2003. Available from: http://dyuthi.cusat.ac.in/purl/2117

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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