subject:(mouse)

University of Georgia

1. Kalaskar, Vijay Kumar. Analysis of the role of BMP signaling in early eye development.

Degree: PhD, Neuroscience, 2014, University of Georgia

URL: http://purl.galileo.usg.edu/uga_etd/kalaskar_vijay_k_201405_phd

► Bone morphogenetic proteins (BMP) and their receptors are expressed in ocular tissue during the stages of early eye specification and development, and are required for… (more)

▼ Bone morphogenetic proteins (BMP) and their receptors are expressed in ocular tissue during the stages of early eye specification and development, and are required for normal eye development. Recent screening of individuals with ocular malformations revealed mutations in the gene locus of one of the BMP members, BMP4. Compared to other BMP members, BMP4 expression is more predominant in ocular tissues during development. Understanding the role of BMP4 has been difficult as BMP4-/- homozygous mouse embryos die at mid-gestation, precluding the study of BMP4 in early eye development. However, co-culture studies revealed that BMP4 signaling in the optic vesicle was essential for its lens inducing activity. Although BMP4 is expressed at later stages, its role in mammalian eye development following lens induction is not clear. My dissertation research was directed towards elucidating the role of BMP signaling in mammalian eye development. To circumvent the problems associated with embryonic lethality, I developed a mouse embryo culture system capable of supporting eye development in a manner consistent with that observed in utero. I manipulated BMP signaling utilizing both gain and loss of function approaches through ectopic expression of BMP4 and Noggin proteins, respectively. I showed that BMP signaling plays several separable roles in eye development including specification, patterning and development. In cultured mouse embryos, ectopic BMP4 prevented development of pigmentation in retinal pigmented epithelium (RPE) through down-regulation of genes involved in RPE specification and development such as Mitf, Otx2 and Pax6. In neural retina (NR), ectopic BMP4 altered expression of genes involved in dorsal-ventral patterning, such as Tbx2, Tbx5, Msx1 and Vax2, and down-regulated the expression of genes involved in NR specification and development, including Vsx2, Pax6, Sox2, Rx and Lhx2. In contrast, loss of BMP signaling resulted in upregulation of genes such as Mitf and Pax6 and changed the expression domains of genes involved in dorsal-ventral patterning. Further analysis revealed that BMP signaling mediated these effects on NR and RPE by modulating the members of WNT and SHH signaling pathways. My results suggest a predominant role for BMP signaling in regulating the mechanisms important in NR and RPE specification and development. Advisors/Committee Members: James D. Lauderdale.

Subjects/Keywords: Mouse embryo

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APA (6^th Edition):

Kalaskar, V. K. (2014). Analysis of the role of BMP signaling in early eye development. (Doctoral Dissertation). University of Georgia. Retrieved from http://purl.galileo.usg.edu/uga_etd/kalaskar_vijay_k_201405_phd

Chicago Manual of Style (16^th Edition):

Kalaskar, Vijay Kumar. “Analysis of the role of BMP signaling in early eye development.” 2014. Doctoral Dissertation, University of Georgia. Accessed February 27, 2020. http://purl.galileo.usg.edu/uga_etd/kalaskar_vijay_k_201405_phd.

MLA Handbook (7^th Edition):

Kalaskar, Vijay Kumar. “Analysis of the role of BMP signaling in early eye development.” 2014. Web. 27 Feb 2020.

Vancouver:

Kalaskar VK. Analysis of the role of BMP signaling in early eye development. [Internet] [Doctoral dissertation]. University of Georgia; 2014. [cited 2020 Feb 27]. Available from: http://purl.galileo.usg.edu/uga_etd/kalaskar_vijay_k_201405_phd.

Council of Science Editors:

Kalaskar VK. Analysis of the role of BMP signaling in early eye development. [Doctoral Dissertation]. University of Georgia; 2014. Available from: http://purl.galileo.usg.edu/uga_etd/kalaskar_vijay_k_201405_phd

2. Lau, Bonnie W. CXCR4/SDF1 in recruitment of stem cells to orthotopic murine malignant mesothelioma spheroids.

Degree: PhD, Division of Biology and Medicine. Pathobiology, 2009, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:148/

► Malignant mesothelioma is an aggressive cancer of the mesothelial lining causally linked to asbestos exposure and is highly resistant to current therapies. We hypothesize a… (more)

▼ Malignant mesothelioma is an aggressive cancer of the mesothelial lining causally linked to asbestos exposure and is highly resistant to current therapies. We hypothesize a stem/progenitor cell population is recruited to the tumor and contributes to tumor cell growth and progression. Using an orthotopic murine tumor spheroid model shown to recapitulate human malignant mesothelioma, we identified a stem cell antigen-1 (Sca-1) positive cell population recruited to tumor spheroids in vivo. The Sca-1+ cell population was characterized by immunofluorescence staining and flow cytometry. Candidate chemokines involved in recruitment of this stem/progenitor cell population were identified with SuperArrayTM, and confirmed with ELISA and transwell migration assays. To test whether this recruited cell population contributes to tumor cell proliferation, malignant mesothelioma cells were grown in conditioned media from in vitro cultures and tumor cell proliferation was assessed. To test whether this cell population contributes to tumor progression in vivo, tumor cell-injected mice were treated with chemotactic inhibitors and tumor burden was assessed as compared to vehicle-injected control mice. The Sca-1+ cell population co-expresses markers for T lymphocytes, hematopoietic stem cells and mesenchymal stem cells. The tumor microenvironment expresses the chemokine SDF-1/CXCL12 and the cognate receptor CXCR4 that are involved in recruitment of these cell types. Involvement of the CXCR4/SDF1 chemotactic axis was confirmed when transwell migration of mesenchymal stem cells to lavage fluid was abrogated by treatment with small molecule inhibitors of CXCR4. Once recruited, this stem/progenitor cell population secretes factors that increase tumor cell proliferation. In conclusion, a stem/progenitor cell population is recruited to malignant mesothelioma spheroids, secretes factors that promote tumor cell growth and is a potentially novel therapeutic target. Advisors/Committee Members: Kane, Agnes (director), Broaddus, Courtney (reader), Padbury, James (reader), Morgan, Jeffrey (reader), Zhitkovich, Anatoly (reader).

Subjects/Keywords: mouse model

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APA (6^th Edition):

Lau, B. W. (2009). CXCR4/SDF1 in recruitment of stem cells to orthotopic murine malignant mesothelioma spheroids. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:148/

Chicago Manual of Style (16^th Edition):

Lau, Bonnie W. “CXCR4/SDF1 in recruitment of stem cells to orthotopic murine malignant mesothelioma spheroids.” 2009. Doctoral Dissertation, Brown University. Accessed February 27, 2020. https://repository.library.brown.edu/studio/item/bdr:148/.

MLA Handbook (7^th Edition):

Lau, Bonnie W. “CXCR4/SDF1 in recruitment of stem cells to orthotopic murine malignant mesothelioma spheroids.” 2009. Web. 27 Feb 2020.

Vancouver:

Lau BW. CXCR4/SDF1 in recruitment of stem cells to orthotopic murine malignant mesothelioma spheroids. [Internet] [Doctoral dissertation]. Brown University; 2009. [cited 2020 Feb 27]. Available from: https://repository.library.brown.edu/studio/item/bdr:148/.

Council of Science Editors:

Lau BW. CXCR4/SDF1 in recruitment of stem cells to orthotopic murine malignant mesothelioma spheroids. [Doctoral Dissertation]. Brown University; 2009. Available from: https://repository.library.brown.edu/studio/item/bdr:148/

University of Hawaii – Manoa

3. Raman, Arjun Venkat. Utilization of selenium in the mouse brain : implications for neurological disease.

Degree: 2016, University of Hawaii – Manoa

URL: http://hdl.handle.net/10125/101018

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Ph.D. University of Hawaii at Manoa 2012.

Selenium is a chemical element that is an essential micronutrient associated with various aspects of human health. The… (more)

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Ph.D. University of Hawaii at Manoa 2012.

Selenium is a chemical element that is an essential micronutrient associated with various aspects of human health. The biochemical activity of selenium is mediated by proteins, which incorporate it into the amino acid selenocysteine (Sec). There are 25 genes in humans encoding Sec-containing selenoproteins. The functionally characterized selenoproteins are oxidoreductase enzymes involved in cellular oxidation-reduction reactions. Most selenoproteins are expressed in the mammalian brain, and dietary selenium deficiency causes preferential retention in brain relative to other body organs. Further, dietary selenium deficiency and specific selenoproteins are associated with various brain diseases. Mouse models have been extensively used to study the function and handling of selenium in mammals. Genetic deletion of a Sec-rich protein in mice causes brain selenium deficiency, neurodegeneration and neurological impairment, and disruption of a phospholipid hydroperoxidase selenoenzyme causes rapid neurodegeneration. Therefore, selenoprotein expression and function promotes a healthy nervous system. However, selenium metabolism and the function of several selenoproteins in brain are not clearly defined. The overall purpose of this work is to clarify the function and utilization of selenium in the mammalian brain, to reveal implications for developmental and neurological diseases. The goal of these studies is to investigate changes in brain function and selenoprotein expression under conditions of altered selenium metabolism in mice. The research presented in this dissertation covers three major topics that are separated into chapters. To investigate selenium distribution in the brain, the neurological consequences of disrupting selenium transport and recycling in mice are assessed and compared. Disruption of selenium transport caused more profound neurological consequences than disruption of selenium recycling. To investigate potential functions of selenium in the nervous system, select selenoproteins were examined for cellular and subcellular expression in cells and brain tissue from transgenic and control mice. Select selenoproteins and synthesis factors were observed at synapses, suggesting localized expression and physiological relevance. To investigate a potential interaction between selenium and methamphetamine, expression profiling of selenoproteins in mouse brain after exposure to methamphetamine is described. Selenoprotein synthesis was adversely affected by methamphetamine administration in mice. These results confirm the importance of selenium in the mammalian brain.

Subjects/Keywords: selenium; mouse; brain

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APA (6^th Edition):

Raman, A. V. (2016). Utilization of selenium in the mouse brain : implications for neurological disease. (Thesis). University of Hawaii – Manoa. Retrieved from http://hdl.handle.net/10125/101018

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Raman, Arjun Venkat. “Utilization of selenium in the mouse brain : implications for neurological disease.” 2016. Thesis, University of Hawaii – Manoa. Accessed February 27, 2020. http://hdl.handle.net/10125/101018.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Raman, Arjun Venkat. “Utilization of selenium in the mouse brain : implications for neurological disease.” 2016. Web. 27 Feb 2020.

Vancouver:

Raman AV. Utilization of selenium in the mouse brain : implications for neurological disease. [Internet] [Thesis]. University of Hawaii – Manoa; 2016. [cited 2020 Feb 27]. Available from: http://hdl.handle.net/10125/101018.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Raman AV. Utilization of selenium in the mouse brain : implications for neurological disease. [Thesis]. University of Hawaii – Manoa; 2016. Available from: http://hdl.handle.net/10125/101018

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Dalhousie University

4. King, Jillian. Visual Adaptation in Mouse Primary Visual Cortex.

Degree: MS, Department of Psychology and Neuroscience, 2014, Dalhousie University

URL: http://hdl.handle.net/10222/55995

► Studying vision in mice is a relatively recent endeavor, with most research dating within the last 10 years. One goal of this research is to… (more)

Subjects/Keywords: mouse; vision; adaptation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

King, J. (2014). Visual Adaptation in Mouse Primary Visual Cortex. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/55995

Chicago Manual of Style (16^th Edition):

King, Jillian. “Visual Adaptation in Mouse Primary Visual Cortex.” 2014. Masters Thesis, Dalhousie University. Accessed February 27, 2020. http://hdl.handle.net/10222/55995.

MLA Handbook (7^th Edition):

King, Jillian. “Visual Adaptation in Mouse Primary Visual Cortex.” 2014. Web. 27 Feb 2020.

Vancouver:

King J. Visual Adaptation in Mouse Primary Visual Cortex. [Internet] [Masters thesis]. Dalhousie University; 2014. [cited 2020 Feb 27]. Available from: http://hdl.handle.net/10222/55995.

Council of Science Editors:

King J. Visual Adaptation in Mouse Primary Visual Cortex. [Masters Thesis]. Dalhousie University; 2014. Available from: http://hdl.handle.net/10222/55995

University of Adelaide

5. Shahrin, Nur Hezrin. Investigation of KLF5 function in normal haemopoiesis.

Degree: 2015, University of Adelaide

URL: http://hdl.handle.net/2440/92812

► Krüppel-like factor 5 (KLF5) is a zinc-finger transcription factor known to have regulatory roles in the growth and differentiation of many adult tissues. In humans,… (more)

▼ Krüppel-like factor 5 (KLF5) is a zinc-finger transcription factor known to have regulatory roles in the growth and differentiation of many adult tissues. In humans, KLF5 is located at 13q21-22, which is frequently lost in multiple tumour types, including tumours of the breast, endometrium, ovary and prostate where it is associated with loss of KLF5 expression. Little is known about the potential role of KLF5 in the haemopoietic system. Previous work by us and others has shown that KLF5 has a functional role in induction of differentiation of the myeloid compartment. In acute myeloid leukaemia (AML), our group has previously show that KLF5 expression is reduced relatively to normal CD34⁺ cells and that reduction of expression is associated with hypermethylation in intron 1. We also found that hypermethylation of KLF5 was associated with poor outcome, identifying KLF5 as an important target for further investigation in haemopoiesis and particularly the myeloid compartment. To extend the functional analysis of Klf5, an in vivo gene-ablation model was generated. As nonconditional Klf5 knockout mice (KO) die at embryonic day 8.5, pan-haemopoietic Klf5 conditional gene KO mice were generated by crossing Klf5fl/fl [fl/fl superscript] mice with Vav-cre transgenic mice. The Klf5fl/flVav-cre⁺ʹ⁻ [fl/fl superscript] and Klf5fl/fl [fl/fl superscript] mice were analysed at 3, 9 and 12 month of age for defects in steady state haemopoiesis. Peripheral blood (PB) analysis of 9 and 12 month old mice revealed that Klf5fl/flVav-cre⁺ʹ⁻ [fl/fl superscript] animals displayed significantly higher values for total white blood cell (WBC) count. To further characterise the changes in blood cell populations, flow cytometry was used with a range of different lineage antibody markers. The peripheral blood data indicated a decrease in the granulocytes of Klf5fl/flVav-cre⁺ʹ⁻ [fl/fl superscript] mice as well as an increase in the T-cell compartment. Interestingly, we also showed that the Klf5fl/flVav-cre⁺ʹ⁻ [fl/fl superscript] mice have increased numbers of blood and bone marrow eosinophils compared to Klf5fl/f [fl/fl superscript] mice. Consistently, we found significantly increased numbers of eosinophils in the lungs of Klf5fl/flVav-cre⁺ʹ⁻ [fl/fl superscript] mice compared to Klf5fl/fl [fl/fl superscript] mice. The spleen weight of Klf5fl/flVav-cre⁺ʹ⁻ [fl/fl superscript] mice was significantly higher compared to Klf5fl/fl [fl/fl superscript] mice. In addition, clonal assays conducted from the spleen of 9 and 12 month old mice showed a significant increase in colony number in the Klf5fl/flVav-cre⁺ʹ⁻ [fl/fl superscript]mice compared to Klf5fl/fl [fl/fl superscript] mice. This correlated with the flow cytometry data which showed a significant increase in haemopoietic stem cell (HSC) populations; short-term HSC (ST-HSC) and multipotent progenitor (MPP) in the spleen of Klf5fl/flVav-cre⁺ʹ⁻ [fl/fl superscript] mice. In summary, this study revealed multiple functional roles for Klf5 in haemopoiesis. Firstly, these studies demonstrated that as predicted… Advisors/Committee Members: D'Andrea, Richard James (advisor), Brown, Anna Louise (advisor), School of Molecular and Biomedical Science (school).

Subjects/Keywords: KLF5; haemopoiesis; mouse

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APA (6^th Edition):

Shahrin, N. H. (2015). Investigation of KLF5 function in normal haemopoiesis. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/92812

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shahrin, Nur Hezrin. “Investigation of KLF5 function in normal haemopoiesis.” 2015. Thesis, University of Adelaide. Accessed February 27, 2020. http://hdl.handle.net/2440/92812.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shahrin, Nur Hezrin. “Investigation of KLF5 function in normal haemopoiesis.” 2015. Web. 27 Feb 2020.

Vancouver:

Shahrin NH. Investigation of KLF5 function in normal haemopoiesis. [Internet] [Thesis]. University of Adelaide; 2015. [cited 2020 Feb 27]. Available from: http://hdl.handle.net/2440/92812.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shahrin NH. Investigation of KLF5 function in normal haemopoiesis. [Thesis]. University of Adelaide; 2015. Available from: http://hdl.handle.net/2440/92812

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

6. Kim, Dennis. Molecular Genetic Analysis of the Mouse Anorexia Mutation.

Degree: 2010, University of Toronto

URL: http://hdl.handle.net/1807/32211

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The serotonergic system regulates numerous behaviours and disruptions in this system have been associated with disorders of mood and mind. Although molecular genetic analysis has… (more)

Subjects/Keywords: serotonin; mouse; 0369

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kim, D. (2010). Molecular Genetic Analysis of the Mouse Anorexia Mutation. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/32211

Chicago Manual of Style (16^th Edition):

Kim, Dennis. “Molecular Genetic Analysis of the Mouse Anorexia Mutation.” 2010. Masters Thesis, University of Toronto. Accessed February 27, 2020. http://hdl.handle.net/1807/32211.

MLA Handbook (7^th Edition):

Kim, Dennis. “Molecular Genetic Analysis of the Mouse Anorexia Mutation.” 2010. Web. 27 Feb 2020.

Vancouver:

Kim D. Molecular Genetic Analysis of the Mouse Anorexia Mutation. [Internet] [Masters thesis]. University of Toronto; 2010. [cited 2020 Feb 27]. Available from: http://hdl.handle.net/1807/32211.

Council of Science Editors:

Kim D. Molecular Genetic Analysis of the Mouse Anorexia Mutation. [Masters Thesis]. University of Toronto; 2010. Available from: http://hdl.handle.net/1807/32211

University of Texas – Austin

7. -7420-459X. Computations in the early visual system in the mouse.

Degree: PhD, Neuroscience, 2019, University of Texas – Austin

URL: http://dx.doi.org/10.26153/tsw/5681

► In this dissertation, I have explored the mechanisms underlying the selectivity of different visual features in the mouse. I have compared these mechanisms to the… (more)

▼ In this dissertation, I have explored the mechanisms underlying the selectivity of different visual features in the mouse. I have compared these mechanisms to the canonical mechanisms for extracting these features. In chapter 2, I have demonstrated existence of nonclassical receptive fields in which the orientation preference can depend on the spatial frequency, in the mouse visual cortex. I have compared the experimental data with a model based on random connectivity between cells which predicts existence of such receptive fields. In chapter 3, I have studied the input differences between V1 neurons with varying degrees of linearity in spatial summation. I have demonstrated evidence of connectivity which deviates from the standard hierarchical connectivity model. I show that nonlinear cells in the mouse V1 can receive thalamic input which can itself be nonlinear and also orientation selective. In chapter 4, I have studied the development of binocular disparity tuning and using monocular deprivation. I show that disparity selectivity in the mouse is reduced following contralateral eye deprivation during critical period. This effect is due to a disruption of existing disparity selectivity in the circuit following deprivation, as we observe no difference in degree of selectivity between adult animals and young mice before critical period. This disruption may be due to formation of new inputs which disrupt the matching between left and right eye existing inputs. We provide evidence for this by demonstrating a reduction in spatial acuity for the open eye inputs following deprivation. Across all of these studies, I demonstrate multiple instances in which the mouse pathways differ from the classical early visual pathways. But I also find evidence for a distinctive connectivity, similar to the classical models. My thesis highlights the diversity in circuit computations which leads to the processing outcomes that are shared across the mammalian species Advisors/Committee Members: Priebe, Nicholas (advisor), Aldrich, Richard W (committee member), Fiete, Ila (committee member), Huk, Alexander C (committee member), Movshon, J Anthony (committee member).

Subjects/Keywords: Mouse; Vision; Neurons; Mouse visual system; Mouse visual features; Mouse visual cortex

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APA (6^th Edition):

-7420-459X. (2019). Computations in the early visual system in the mouse. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://dx.doi.org/10.26153/tsw/5681

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Chicago Manual of Style (16^th Edition):

-7420-459X. “Computations in the early visual system in the mouse.” 2019. Doctoral Dissertation, University of Texas – Austin. Accessed February 27, 2020. http://dx.doi.org/10.26153/tsw/5681.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

MLA Handbook (7^th Edition):

-7420-459X. “Computations in the early visual system in the mouse.” 2019. Web. 27 Feb 2020.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

-7420-459X. Computations in the early visual system in the mouse. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2019. [cited 2020 Feb 27]. Available from: http://dx.doi.org/10.26153/tsw/5681.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Council of Science Editors:

-7420-459X. Computations in the early visual system in the mouse. [Doctoral Dissertation]. University of Texas – Austin; 2019. Available from: http://dx.doi.org/10.26153/tsw/5681

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

University of Utah

8. Arch, Dorinda Deana. Altered liver parameters in a genetic mouse model of porphyria cutanea tarda and possible involvement of ABC transporters in the disease.

Degree: PhD, Pharmacology & Toxicology;, 2010, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/62/rec/68

► The project sought to examine the changes in the liver associated with porphyria and whether ATP binding cassette (ABC) transporters in the hepatocyte might in… (more)

Subjects/Keywords: Liver parameters; Mouse model

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APA (6^th Edition):

Arch, D. D. (2010). Altered liver parameters in a genetic mouse model of porphyria cutanea tarda and possible involvement of ABC transporters in the disease. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/62/rec/68

Chicago Manual of Style (16^th Edition):

Arch, Dorinda Deana. “Altered liver parameters in a genetic mouse model of porphyria cutanea tarda and possible involvement of ABC transporters in the disease.” 2010. Doctoral Dissertation, University of Utah. Accessed February 27, 2020. http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/62/rec/68.

MLA Handbook (7^th Edition):

Arch, Dorinda Deana. “Altered liver parameters in a genetic mouse model of porphyria cutanea tarda and possible involvement of ABC transporters in the disease.” 2010. Web. 27 Feb 2020.

Vancouver:

Arch DD. Altered liver parameters in a genetic mouse model of porphyria cutanea tarda and possible involvement of ABC transporters in the disease. [Internet] [Doctoral dissertation]. University of Utah; 2010. [cited 2020 Feb 27]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/62/rec/68.

Council of Science Editors:

Arch DD. Altered liver parameters in a genetic mouse model of porphyria cutanea tarda and possible involvement of ABC transporters in the disease. [Doctoral Dissertation]. University of Utah; 2010. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/62/rec/68

University of Georgia

9. Greene, Daniel Uriah. Trapping study of the endangered Key Largo cotton mouse (Peromyscus gossypinus allapaticola): a protocol for long-term population monitoring.

Degree: MS, Forest Resources, 2009, University of Georgia

URL: http://purl.galileo.usg.edu/uga_etd/greene_daniel_u_200905_ms

► The Key Largo cotton mouse (Peromyscus gossypinus allapaticola), a federally endangered sub-species of the cotton mouse, is currently restricted to less than 50% of its… (more)

Subjects/Keywords: Key Largo cotton mouse

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APA (6^th Edition):

Greene, D. U. (2009). Trapping study of the endangered Key Largo cotton mouse (Peromyscus gossypinus allapaticola): a protocol for long-term population monitoring. (Masters Thesis). University of Georgia. Retrieved from http://purl.galileo.usg.edu/uga_etd/greene_daniel_u_200905_ms

Chicago Manual of Style (16^th Edition):

Greene, Daniel Uriah. “Trapping study of the endangered Key Largo cotton mouse (Peromyscus gossypinus allapaticola): a protocol for long-term population monitoring.” 2009. Masters Thesis, University of Georgia. Accessed February 27, 2020. http://purl.galileo.usg.edu/uga_etd/greene_daniel_u_200905_ms.

MLA Handbook (7^th Edition):

Greene, Daniel Uriah. “Trapping study of the endangered Key Largo cotton mouse (Peromyscus gossypinus allapaticola): a protocol for long-term population monitoring.” 2009. Web. 27 Feb 2020.

Vancouver:

Greene DU. Trapping study of the endangered Key Largo cotton mouse (Peromyscus gossypinus allapaticola): a protocol for long-term population monitoring. [Internet] [Masters thesis]. University of Georgia; 2009. [cited 2020 Feb 27]. Available from: http://purl.galileo.usg.edu/uga_etd/greene_daniel_u_200905_ms.

Council of Science Editors:

Greene DU. Trapping study of the endangered Key Largo cotton mouse (Peromyscus gossypinus allapaticola): a protocol for long-term population monitoring. [Masters Thesis]. University of Georgia; 2009. Available from: http://purl.galileo.usg.edu/uga_etd/greene_daniel_u_200905_ms

University of Georgia

10. Moore, Martin Lawrence. Host immune response to mouse adenovirus type 1.

Degree: PhD, Genetics, 2003, University of Georgia

URL: http://purl.galileo.usg.edu/uga_etd/moore_martin_l_200312_phd

► Mouse adenovirus type 1 (MAV-1) provides a model of adenovirus pathogenesis. MAV-1 induces dose-dependent encephalomyelitis. To characterize the role of specific mechanisms of immunity in… (more)

▼ Mouse adenovirus type 1 (MAV-1) provides a model of adenovirus pathogenesis. MAV-1 induces dose-dependent encephalomyelitis. To characterize the role of specific mechanisms of immunity in MAV-1-induced disease, immunodeficient mouse models were utilized. T cells, major histocompatibility complex class I, and perforin contributed to MAV-1- induced acute disease. Mice lacking á / T cells succumbed to MAV-1 infection 9 to 16 weeks post-infection. á / T cells were required for clearance of infectious MAV-1 and for long-term survival. Mice lacking CD8 + T cells and mice lacking CD4 + T cells cleared MAV-1 like controls. These data are consistent with a model in which CD8 + T cells induce acute immunopathology and either CD8 + T cells or CD4 + T cells are required for long-term control of MAV-1 replication. B cell-deficient mice were highly susceptible to acute MAV-1 infection and succumbed with high viral loads, disseminated infection, and hepatitis. It was hypothesized that a T cell-independent (TI) B cell response is the critical protective mechanism. Bruton’s tyrosine kinase-deficient mice have reduced numbers of B cells and are unable to mount TI B cell responses to some antigens. Loss of Btk in mice results in the classic X-linked immunodeficiency (Xid) phenotype. Btk was required for survival of acute MAV-1 infection, demonstrating for the first time that Btk plays a role in protection from virus-induced disease in mice. Survival of acute MAV-1 infection correlated with TI antiviral IgM production, and treatment of lethally infected Btk-deficient mice with early anti-MAV-1 antiserum was protective. The role of interferon-á / (IFN-á /) signaling in MAV-1 infection was investigated using IFN-á / receptor null mice (IFN-á /R -/- ). Surprisingly, MAV-1 virulence and replication in the brain was not significantly altered in IFN-á /R -/- mice relative to control mice. However, IFN-á /R -/- mice exhibited a more disseminated MAV-1 infection than controls, indicating that IFN-á / is a determinant of MAV-1 organ tropism. IFN-stimulated genes (ISGs) whose steady-state mRNA levels were increased by MAV-1 infection in vitro and in vivo were identified. Northern analyses of mRNAs in infected mice suggest that interferon regulatory factor 7 and major histocompatibility complex class I play a role in IFN-á / signaling-dependent control of MAV-1 organ tropism. Advisors/Committee Members: Mary Bedell.

Subjects/Keywords: Mouse adenovirus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Moore, M. L. (2003). Host immune response to mouse adenovirus type 1. (Doctoral Dissertation). University of Georgia. Retrieved from http://purl.galileo.usg.edu/uga_etd/moore_martin_l_200312_phd

Chicago Manual of Style (16^th Edition):

Moore, Martin Lawrence. “Host immune response to mouse adenovirus type 1.” 2003. Doctoral Dissertation, University of Georgia. Accessed February 27, 2020. http://purl.galileo.usg.edu/uga_etd/moore_martin_l_200312_phd.

MLA Handbook (7^th Edition):

Moore, Martin Lawrence. “Host immune response to mouse adenovirus type 1.” 2003. Web. 27 Feb 2020.

Vancouver:

Moore ML. Host immune response to mouse adenovirus type 1. [Internet] [Doctoral dissertation]. University of Georgia; 2003. [cited 2020 Feb 27]. Available from: http://purl.galileo.usg.edu/uga_etd/moore_martin_l_200312_phd.

Council of Science Editors:

Moore ML. Host immune response to mouse adenovirus type 1. [Doctoral Dissertation]. University of Georgia; 2003. Available from: http://purl.galileo.usg.edu/uga_etd/moore_martin_l_200312_phd

University of Alberta

11. Yang, Fang. Characterizing the role of CECR1 in cat eye syndrome by using mouse models.

Degree: MS, Department of Biological Sciences, 2010, University of Alberta

URL: https://era.library.ualberta.ca/files/w0892c29j

► CECR1 (cat eye syndrome chromosome region, candidate 1) is located on chromosome 22q11.2. Duplication of this region results in the human disorder cat eye syndrome… (more)

Subjects/Keywords: CECR1; mouse; cat eye syndrome

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APA (6^th Edition):

Yang, F. (2010). Characterizing the role of CECR1 in cat eye syndrome by using mouse models. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/w0892c29j

Chicago Manual of Style (16^th Edition):

Yang, Fang. “Characterizing the role of CECR1 in cat eye syndrome by using mouse models.” 2010. Masters Thesis, University of Alberta. Accessed February 27, 2020. https://era.library.ualberta.ca/files/w0892c29j.

MLA Handbook (7^th Edition):

Yang, Fang. “Characterizing the role of CECR1 in cat eye syndrome by using mouse models.” 2010. Web. 27 Feb 2020.

Vancouver:

Yang F. Characterizing the role of CECR1 in cat eye syndrome by using mouse models. [Internet] [Masters thesis]. University of Alberta; 2010. [cited 2020 Feb 27]. Available from: https://era.library.ualberta.ca/files/w0892c29j.

Council of Science Editors:

Yang F. Characterizing the role of CECR1 in cat eye syndrome by using mouse models. [Masters Thesis]. University of Alberta; 2010. Available from: https://era.library.ualberta.ca/files/w0892c29j

Texas A&M University

12. Villarreal, Dorissa. Neurotropism of Theiler's murine encephalomyelitis virus.

Degree: 2005, Texas A&M University

URL: http://hdl.handle.net/1969.1/2647

► Theiler??s murine encephalomyelitis virus (TMEV) can infect the central nervous system (CNS) and cause neurological damage. The exact route by which TMEV enters the CNS… (more)

Subjects/Keywords: Mouse; Virus

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APA (6^th Edition):

Villarreal, D. (2005). Neurotropism of Theiler's murine encephalomyelitis virus. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/2647

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Villarreal, Dorissa. “Neurotropism of Theiler's murine encephalomyelitis virus.” 2005. Thesis, Texas A&M University. Accessed February 27, 2020. http://hdl.handle.net/1969.1/2647.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Villarreal, Dorissa. “Neurotropism of Theiler's murine encephalomyelitis virus.” 2005. Web. 27 Feb 2020.

Vancouver:

Villarreal D. Neurotropism of Theiler's murine encephalomyelitis virus. [Internet] [Thesis]. Texas A&M University; 2005. [cited 2020 Feb 27]. Available from: http://hdl.handle.net/1969.1/2647.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Villarreal D. Neurotropism of Theiler's murine encephalomyelitis virus. [Thesis]. Texas A&M University; 2005. Available from: http://hdl.handle.net/1969.1/2647

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

13. Epple - Farmer, Jessica Anne. Gender dependent survival of allogeneic trophoblast stem cells.

Degree: 2009, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-3047

► Pregnancy succeeds because the fetal allograft survives in the presence of a fully functional maternal immune system. The placenta, especially its trophoblast, provides the initial… (more)

Subjects/Keywords: embronic stem cell; mouse

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APA (6^th Edition):

Epple - Farmer, J. A. (2009). Gender dependent survival of allogeneic trophoblast stem cells. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-3047

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Epple - Farmer, Jessica Anne. “Gender dependent survival of allogeneic trophoblast stem cells.” 2009. Thesis, Texas A&M University. Accessed February 27, 2020. http://hdl.handle.net/1969.1/ETD-TAMU-3047.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Epple - Farmer, Jessica Anne. “Gender dependent survival of allogeneic trophoblast stem cells.” 2009. Web. 27 Feb 2020.

Vancouver:

Epple - Farmer JA. Gender dependent survival of allogeneic trophoblast stem cells. [Internet] [Thesis]. Texas A&M University; 2009. [cited 2020 Feb 27]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-3047.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Epple - Farmer JA. Gender dependent survival of allogeneic trophoblast stem cells. [Thesis]. Texas A&M University; 2009. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-3047

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

14. Bhatia, Sahil. Geometrically Decoupled Phased Array Coils for Mouse Imaging.

Degree: 2010, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-2009-05-797

► Phased array surface coils offer high SNR over a large field of view. Phased array volume coils have high SNR at the surface and centre… (more)

Subjects/Keywords: Mouse coils; Phased array

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APA (6^th Edition):

Bhatia, S. (2010). Geometrically Decoupled Phased Array Coils for Mouse Imaging. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2009-05-797

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bhatia, Sahil. “Geometrically Decoupled Phased Array Coils for Mouse Imaging.” 2010. Thesis, Texas A&M University. Accessed February 27, 2020. http://hdl.handle.net/1969.1/ETD-TAMU-2009-05-797.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bhatia, Sahil. “Geometrically Decoupled Phased Array Coils for Mouse Imaging.” 2010. Web. 27 Feb 2020.

Vancouver:

Bhatia S. Geometrically Decoupled Phased Array Coils for Mouse Imaging. [Internet] [Thesis]. Texas A&M University; 2010. [cited 2020 Feb 27]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2009-05-797.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bhatia S. Geometrically Decoupled Phased Array Coils for Mouse Imaging. [Thesis]. Texas A&M University; 2010. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2009-05-797

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Minnesota

15. Pisansky, Marc. Oxytocin and epigenetic mechanisms in mouse models of empathy and autism.

Degree: PhD, Neuroscience, 2016, University of Minnesota

URL: http://hdl.handle.net/11299/182773

► Empathy, the capacity to infer the emotional state of another, represents a normal process of social cognition that is impaired in several psychiatric diseases. This… (more)

Subjects/Keywords: Autism; Empathy; Epigenetics; Mouse; Oxytocin

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APA (6^th Edition):

Pisansky, M. (2016). Oxytocin and epigenetic mechanisms in mouse models of empathy and autism. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/182773

Chicago Manual of Style (16^th Edition):

Pisansky, Marc. “Oxytocin and epigenetic mechanisms in mouse models of empathy and autism.” 2016. Doctoral Dissertation, University of Minnesota. Accessed February 27, 2020. http://hdl.handle.net/11299/182773.

MLA Handbook (7^th Edition):

Pisansky, Marc. “Oxytocin and epigenetic mechanisms in mouse models of empathy and autism.” 2016. Web. 27 Feb 2020.

Vancouver:

Pisansky M. Oxytocin and epigenetic mechanisms in mouse models of empathy and autism. [Internet] [Doctoral dissertation]. University of Minnesota; 2016. [cited 2020 Feb 27]. Available from: http://hdl.handle.net/11299/182773.

Council of Science Editors:

Pisansky M. Oxytocin and epigenetic mechanisms in mouse models of empathy and autism. [Doctoral Dissertation]. University of Minnesota; 2016. Available from: http://hdl.handle.net/11299/182773

North Carolina State University

16. Summers, Caroline Rueda. Modulation of Inflammatory Responses by Green and Black Tea in LPS-induced RAW 264.7 Cells.

Degree: MS, Nutrition, 2010, North Carolina State University

URL: http://www.lib.ncsu.edu/resolver/1840.16/6332

► Recently, the World Health Organization estimated that chronic diseases are responsible for 46% of disease occurrence and 59% of all deaths worldwide. Growing evidence suggests… (more)

▼ Recently, the World Health Organization estimated that chronic diseases are responsible for 46% of disease occurrence and 59% of all deaths worldwide. Growing evidence suggests that increasing chronic disease incidence is dependent upon several factors, including inadequate consumption of antioxidant-rich fruits and vegetables and chronic inflammation. Many researchers have previously investigated potential health benefits associated with consuming plant-based foods, and the ability of these foods to prevent or suppress the pathologies linked to chronic diseases. Specifically, plant-based bioactive compounds called polyphenols have been widely studied, and show promise as a therapeutic agent against chronic diseases. Tea is produced from the leaves of the Camellia sinensis plant and, aside from water, is the most popular beverage in the world. Green tea, black tea, and oolong tea are the three major types of commercially produced tea. Black tea comprises over 75% of global tea production and consumption, followed by green tea at approximately 20%, and oolong tea at less than 2%. For centuries, tea has been known for its health effects. It has historically been used as a medicine in China and Japan. Tea polyphenols are particularly thought to have chemopreventive and cardioprotective effects due to their antioxidant and anti-inflammatory properties. Previous in vitro and animal studies have analyzed the anti-inflammatory activity of polyphenols, and the specific mechanisms by which these compounds suppress inflammation. But, to our knowledge, few studies have investigated teaâ€™s anti-inflammatory capacity as a whole food, or compared the potential anti-inflammatory effects of different tea types. Therefore, the objectives of the following study were to evaluate total phenol content in green tea (GT) and black tea (BT); to assess viability of cells exposed to GT, BT, and LPS; and to measure the modulation of inflammatory responses in lipopolysaccharide (LPS)-induced RAW 264.7 mouse macrophages by GT and BT. We predicted that GT and BT would differentially modulate inflammation because of differences in composition. First, the total phenolic content in commercially produced GT and BT was measured using the Folin-Ciocalteu method. Freshly prepared GT had a significantly higher phenolic content than freshly prepared BT (1317.1 + 6.0 GAE, 918.9 + 10.7 GAE). Stored at -80Â° C, the phenolic content of GT and BT significantly increased at one month (1770.0 + 35.2 GAE, 1124.0 + 19.1 GAE) and two months post-preparation (1587.2 + 21.5 GAE, 1003.2 + 8.6 GAE), then decreased at 3 months post-preparation (1407.8 + 13.4 GAE, 941.8 + 0.5 GAE) (p < 0.05). The second goal of our study was to assess viability in RAW 264.7 cells treated with GT, BT, and LPS. Viability was colorimetrically determined by the Trypan Blue assay and by measured absorbance values from the MTT assay. The GT, BT, and LPS treatments did not produce a cytotoxic effect, and cell viability values for each treatment were not significantly… Advisors/Committee Members: Dr. Brenda P. Alston-Mills, Committee Member (advisor), Dr. Jonathan C. Allen, Committee Co-Chair (advisor), Dr. Gabriel Keith Harris, Committee Chair (advisor).

Subjects/Keywords: LPS; tea; mouse macrophage; inflammation

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APA (6^th Edition):

Summers, C. R. (2010). Modulation of Inflammatory Responses by Green and Black Tea in LPS-induced RAW 264.7 Cells. (Thesis). North Carolina State University. Retrieved from http://www.lib.ncsu.edu/resolver/1840.16/6332

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Summers, Caroline Rueda. “Modulation of Inflammatory Responses by Green and Black Tea in LPS-induced RAW 264.7 Cells.” 2010. Thesis, North Carolina State University. Accessed February 27, 2020. http://www.lib.ncsu.edu/resolver/1840.16/6332.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Summers, Caroline Rueda. “Modulation of Inflammatory Responses by Green and Black Tea in LPS-induced RAW 264.7 Cells.” 2010. Web. 27 Feb 2020.

Vancouver:

Summers CR. Modulation of Inflammatory Responses by Green and Black Tea in LPS-induced RAW 264.7 Cells. [Internet] [Thesis]. North Carolina State University; 2010. [cited 2020 Feb 27]. Available from: http://www.lib.ncsu.edu/resolver/1840.16/6332.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Summers CR. Modulation of Inflammatory Responses by Green and Black Tea in LPS-induced RAW 264.7 Cells. [Thesis]. North Carolina State University; 2010. Available from: http://www.lib.ncsu.edu/resolver/1840.16/6332

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

17. Dingle, Yu-Ting Liu. In Vitro Modeling of the Central Nervous System: Towards Optimized Cell-based Therapies.

Degree: PhD, Biomedical Engineering, 2015, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:419530/

► Cell-based therapy is a promising treatment option for central nervous system (CNS) disease and injury, but therapy strategies require optimization to achieve clinical improvement. The… (more)

▼ Cell-based therapy is a promising treatment option for central nervous system (CNS) disease and injury, but therapy strategies require optimization to achieve clinical improvement. The primary motivation of this thesis is to gain knowledge of in vitro neuronal differentiation of stem cells and to develop three-dimensional (3D) culture models to investigate stem cell transplantation to the CNS. The first study in this thesis addressed the heterogeneity of mouse embryonic stem cell-derived dopamine neurons. In vitro, the percentage of calbindin+ subtype of DA neurons was higher than the calretinin+ subtype, which was a similar trend to in vivo. In addition, dopamine neuron subtype generation in vitro was not governed by exogenous sonic hedgehog and fibroblast growth factor 8. In the second study, we developed a scaffold-free, 3D neural spheroid culture using primary rat cerebral cortex cells. Cortical cells in agarose hydrogels containing round-bottom microwells self-assembled into spheroids. The 3D neural spheroids recapitulated key in vivo-like features including 3D neuronal and astroglial network formation, extracellular matrix production, electrical activity, circuitry formation via excitatory and inhibitory synapses, and brain-like mechanical properties. These physiologically relevant characteristics make these spheroids an effective in vitro model for the CNS. In the third study, we expanded the 3D culture technique to develop an in vitro model for stem cell transplantation to the CNS. To represent the host CNS tissue in vitro, trampoline-shaped 3D microtissues were fabricated using cortical cells. Neural stem cells (NSCs) in the form of spheroids were placed in the center of the CNS host trampoline microtissues, and NSC behavior in this transplantation model construct was monitored. In a proof-of-concept experiment, we utilized this model to test the effect of fibroblast growth factor 2 on NSC migration. Based on the microtissue characterization results, this 3D in vitro transplantation model has the potential to generate more translatable results than 2D co-culture platforms. These works together contribute to a deeper understanding of in vitro generation of neurons and provide a novel in vitro 3D engineered CNS model for the investigation of cell-based therapies. Advisors/Committee Members: Hoffman-Kim, Diane (Director), Morgan, Jeffrey (Reader), Darling, Eric (Reader), Coulombe, Kareen (Reader), Kaplan, David (Reader).

Subjects/Keywords: mouse embryonic stem cells

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APA (6^th Edition):

Dingle, Y. L. (2015). In Vitro Modeling of the Central Nervous System: Towards Optimized Cell-based Therapies. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:419530/

Chicago Manual of Style (16^th Edition):

Dingle, Yu-Ting Liu. “In Vitro Modeling of the Central Nervous System: Towards Optimized Cell-based Therapies.” 2015. Doctoral Dissertation, Brown University. Accessed February 27, 2020. https://repository.library.brown.edu/studio/item/bdr:419530/.

MLA Handbook (7^th Edition):

Dingle, Yu-Ting Liu. “In Vitro Modeling of the Central Nervous System: Towards Optimized Cell-based Therapies.” 2015. Web. 27 Feb 2020.

Vancouver:

Dingle YL. In Vitro Modeling of the Central Nervous System: Towards Optimized Cell-based Therapies. [Internet] [Doctoral dissertation]. Brown University; 2015. [cited 2020 Feb 27]. Available from: https://repository.library.brown.edu/studio/item/bdr:419530/.

Council of Science Editors:

Dingle YL. In Vitro Modeling of the Central Nervous System: Towards Optimized Cell-based Therapies. [Doctoral Dissertation]. Brown University; 2015. Available from: https://repository.library.brown.edu/studio/item/bdr:419530/

Purdue University

18. Umapathi, Udayan. Realization And Evaluation Of A 3-Degrees-Of-Freedom Mouse Model.

Degree: MS, Electrical and Computer Engineering, 2014, Purdue University

URL: http://docs.lib.purdue.edu/open_access_theses/387

► Kinesiology research has shown that translation and rotation are inseparable actions in the real world. Motivated by this fact, this thesis explores a model… (more)

Subjects/Keywords: Applied sciences; 3-degrees-of- freedom mouse; Intertial mouse; Mouse; Rotational mouse; Computer Engineering; Electrical and Computer Engineering

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APA (6^th Edition):

Umapathi, U. (2014). Realization And Evaluation Of A 3-Degrees-Of-Freedom Mouse Model. (Thesis). Purdue University. Retrieved from http://docs.lib.purdue.edu/open_access_theses/387

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Umapathi, Udayan. “Realization And Evaluation Of A 3-Degrees-Of-Freedom Mouse Model.” 2014. Thesis, Purdue University. Accessed February 27, 2020. http://docs.lib.purdue.edu/open_access_theses/387.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Umapathi, Udayan. “Realization And Evaluation Of A 3-Degrees-Of-Freedom Mouse Model.” 2014. Web. 27 Feb 2020.

Vancouver:

Umapathi U. Realization And Evaluation Of A 3-Degrees-Of-Freedom Mouse Model. [Internet] [Thesis]. Purdue University; 2014. [cited 2020 Feb 27]. Available from: http://docs.lib.purdue.edu/open_access_theses/387.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Umapathi U. Realization And Evaluation Of A 3-Degrees-Of-Freedom Mouse Model. [Thesis]. Purdue University; 2014. Available from: http://docs.lib.purdue.edu/open_access_theses/387

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brigham Young University

19. Chronis, Rhonda Nicole. Comparison of Cytokine Expression and Bacterial Growth During Periparturient and Mid Lactation Mastitis in a Mouse Model.

Degree: MS, 2017, Brigham Young University

URL: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7847&context=etd

► Clinical cases of bovine mastitis are most severe in the early stages of lactation. The causes of this increased propensity for severe mastitis during early… (more)

Subjects/Keywords: mastitis; periparturient; mouse model; Microbiology

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APA (6^th Edition):

Chronis, R. N. (2017). Comparison of Cytokine Expression and Bacterial Growth During Periparturient and Mid Lactation Mastitis in a Mouse Model. (Masters Thesis). Brigham Young University. Retrieved from https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7847&context=etd

Chicago Manual of Style (16^th Edition):

Chronis, Rhonda Nicole. “Comparison of Cytokine Expression and Bacterial Growth During Periparturient and Mid Lactation Mastitis in a Mouse Model.” 2017. Masters Thesis, Brigham Young University. Accessed February 27, 2020. https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7847&context=etd.

MLA Handbook (7^th Edition):

Chronis, Rhonda Nicole. “Comparison of Cytokine Expression and Bacterial Growth During Periparturient and Mid Lactation Mastitis in a Mouse Model.” 2017. Web. 27 Feb 2020.

Vancouver:

Chronis RN. Comparison of Cytokine Expression and Bacterial Growth During Periparturient and Mid Lactation Mastitis in a Mouse Model. [Internet] [Masters thesis]. Brigham Young University; 2017. [cited 2020 Feb 27]. Available from: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7847&context=etd.

Council of Science Editors:

Chronis RN. Comparison of Cytokine Expression and Bacterial Growth During Periparturient and Mid Lactation Mastitis in a Mouse Model. [Masters Thesis]. Brigham Young University; 2017. Available from: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7847&context=etd

Brunel University

20. Mouro Pinto, Ricardo. Therapeutic testing and epigenetic characterization of Friedreich Ataxia.

Degree: 2009, Brunel University

URL: http://bura.brunel.ac.uk/handle/2438/6335 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538549

► Friedreich ataxia (FRDA) is an autosomal recessive, neurodegenerative disorder with severely debilitating effects and no current cure. FRDA is mainly caused by the hyper-expansion of… (more)

Subjects/Keywords: 616.8; Mouse model; Frataxin; HDACi

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APA (6^th Edition):

Mouro Pinto, R. (2009). Therapeutic testing and epigenetic characterization of Friedreich Ataxia. (Doctoral Dissertation). Brunel University. Retrieved from http://bura.brunel.ac.uk/handle/2438/6335 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538549

Chicago Manual of Style (16^th Edition):

Mouro Pinto, Ricardo. “Therapeutic testing and epigenetic characterization of Friedreich Ataxia.” 2009. Doctoral Dissertation, Brunel University. Accessed February 27, 2020. http://bura.brunel.ac.uk/handle/2438/6335 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538549.

MLA Handbook (7^th Edition):

Mouro Pinto, Ricardo. “Therapeutic testing and epigenetic characterization of Friedreich Ataxia.” 2009. Web. 27 Feb 2020.

Vancouver:

Mouro Pinto R. Therapeutic testing and epigenetic characterization of Friedreich Ataxia. [Internet] [Doctoral dissertation]. Brunel University; 2009. [cited 2020 Feb 27]. Available from: http://bura.brunel.ac.uk/handle/2438/6335 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538549.

Council of Science Editors:

Mouro Pinto R. Therapeutic testing and epigenetic characterization of Friedreich Ataxia. [Doctoral Dissertation]. Brunel University; 2009. Available from: http://bura.brunel.ac.uk/handle/2438/6335 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538549

Universiteit Utrecht

21. Lange, T.A.D. The role of Cdx in embryonic and adult mammalian hematopoiesis.

Degree: 2011, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/209132

► All blood cells orginate from a common stem cell in the bone marrow: the hematopoietic stem cell (HSC), which is characterized by two main properties:… (more)

▼ All blood cells orginate from a common stem cell in the bone marrow: the hematopoietic stem cell (HSC), which is characterized by two main properties: self-renewal and multipotency. Hematopoiesis is a hierarchical system with the HSC at the top. During embryogenesis, hematopoietic cells and progenitors with broader potentials are progressively generated. Mammalian hematopoietic development begins in extra-embryonic structures and continues within the embryo proper. In the conceptus, the mesoderm is patterned along the anterior-posterior (A-P) axis. The positional identity of the mesoderm on the A-P axis is regulated by Hox genes. Cdx genes, another homeobox gene family, are required for the posterior growth of axial tissues during development. Cdx genes are known to act upstream of Hox. The first evidence for a role for Cdx in hematopoiesis was established in zebrafish. Using embryoid bodies, it was shown that the Cdx genes promote embryonic hematopoiesis in the mouse by upregulating target Hox genes. Induction of Cdx4 promotes proliferation of hematopoietic progenitors. HSCs were more successfully derived from ESCs upon Cdx4 and Hoxb4 induction. Cdx gene deficiency jeopardizes embryonic hematopoiesis, with severe consequences for blood development upon Cdx2 mutations. As adult Cdx4 knockout mice only displayed minimal hematopoietic abnormalities, Cdx4 is dispensable for adult hematopoiesis. Previous studies on Cdx1 and Cdx2 mutants did not report any hematopoietic malformations either. However, it was demonstrated that overexpression of Cdx4 promotes leukemia in adult mice and that ectopic expression of Cdx2 is a key event in myeloid leukemia. The Cdx genes thus act as stimulators of hematopoietic progenitor maintenance and proliferation. Loss of function of Cdx impairs embryonic hematopoiesis, whereas gain of function in the adult bone marrow results in overproliferation of hematopoietic progenitors, which can instigate leukemia. Advisors/Committee Members: Deschamps, J..

Subjects/Keywords: hematopoiesis; mouse; Cdx; leukemia

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APA (6^th Edition):

Lange, T. A. D. (2011). The role of Cdx in embryonic and adult mammalian hematopoiesis. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/209132

Chicago Manual of Style (16^th Edition):

Lange, T A D. “The role of Cdx in embryonic and adult mammalian hematopoiesis.” 2011. Masters Thesis, Universiteit Utrecht. Accessed February 27, 2020. http://dspace.library.uu.nl:8080/handle/1874/209132.

MLA Handbook (7^th Edition):

Lange, T A D. “The role of Cdx in embryonic and adult mammalian hematopoiesis.” 2011. Web. 27 Feb 2020.

Vancouver:

Lange TAD. The role of Cdx in embryonic and adult mammalian hematopoiesis. [Internet] [Masters thesis]. Universiteit Utrecht; 2011. [cited 2020 Feb 27]. Available from: http://dspace.library.uu.nl:8080/handle/1874/209132.

Council of Science Editors:

Lange TAD. The role of Cdx in embryonic and adult mammalian hematopoiesis. [Masters Thesis]. Universiteit Utrecht; 2011. Available from: http://dspace.library.uu.nl:8080/handle/1874/209132

Cape Peninsula University of Technology

22. Petrova, Antoinette. Modulation of ultrviolet light induced skin carcinogenesis by extracts of Rooibos and Honeybush using a mouse model:elucidating possible protective mechanisms .

Degree: 2009, Cape Peninsula University of Technology

URL: http://etd.cput.ac.za/handle/20.500.11838/1487

► This thesis provides the first scientific evidence of the photoprotective properties of rooibos and honeybush herbal tea extracts and to some extent, two major honeybush… (more)

▼ This thesis provides the first scientific evidence of the photoprotective properties of rooibos and honeybush herbal tea extracts and to some extent, two major honeybush polyphenols, hesperidin and mangiferin. These properties were demonstrated using in vivo models by: Providing evidence for the inhibition of tumour promotion by ultraviolet B (UVB) radiation in a two-stage skin carcinogenesis mouse model. Topical application of polyphenol-rich extracts of rooibos and honeybush prior to UVB tumour promotion of 7,12-dimethylbenz[a]anthracene (DMBA)-initiated mouse skin, inhibited the formation of tumours. The rooibos and honeybush extracts decreased the incidence and volume of the tumours. Topical application of hesperidin and mangiferin were less effective than the honeybush extracts as only the tumour volume was decreased, but not the incidence. Providing evidence for the inhibition of photodamage of the skin by UVB exposure in a mouse model. Topical application of polyphenolic rich extracts of honeybush prior to UVB irradiation of mouse skin reduced erythema, peeling, oedema and hyperplasia. The depletion of antioxidant enzymes catalase and superoxide dismutase (SOD) was prevented. The extracts protected the skin from oxidative and direct DNA damage, and reduced lipid peroxidation. The induction of cyclooxygenase-2 (COX-2) and ornithine decarboxylase (ODC) was also reduced. Topical application of the polyphenols hesperidin and mangiferin showed reduced protective effects compared to the extracts. Suggesting the possible mechanisms by which honeybush and the polyphenols protect against photocarcinogenesis such as reducing tumour promotion, inflammation and oxidative stress. Suggesting the benefits of including honeybush and rooibos as cosmeceuticals in skin care products and sunscreens as part of the strategy for preventing skin cancer. Discussing the recommendations for further study such as investigating more specific chemopreventive activities of these two South African herbal teas and their polyphenols, dose response studies and clinical evaluations.

Subjects/Keywords: rooibos; honeybush; carcinogenesis; mouse model

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APA (6^th Edition):

Petrova, A. (2009). Modulation of ultrviolet light induced skin carcinogenesis by extracts of Rooibos and Honeybush using a mouse model:elucidating possible protective mechanisms . (Thesis). Cape Peninsula University of Technology. Retrieved from http://etd.cput.ac.za/handle/20.500.11838/1487

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Petrova, Antoinette. “Modulation of ultrviolet light induced skin carcinogenesis by extracts of Rooibos and Honeybush using a mouse model:elucidating possible protective mechanisms .” 2009. Thesis, Cape Peninsula University of Technology. Accessed February 27, 2020. http://etd.cput.ac.za/handle/20.500.11838/1487.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Petrova, Antoinette. “Modulation of ultrviolet light induced skin carcinogenesis by extracts of Rooibos and Honeybush using a mouse model:elucidating possible protective mechanisms .” 2009. Web. 27 Feb 2020.

Vancouver:

Petrova A. Modulation of ultrviolet light induced skin carcinogenesis by extracts of Rooibos and Honeybush using a mouse model:elucidating possible protective mechanisms . [Internet] [Thesis]. Cape Peninsula University of Technology; 2009. [cited 2020 Feb 27]. Available from: http://etd.cput.ac.za/handle/20.500.11838/1487.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Petrova A. Modulation of ultrviolet light induced skin carcinogenesis by extracts of Rooibos and Honeybush using a mouse model:elucidating possible protective mechanisms . [Thesis]. Cape Peninsula University of Technology; 2009. Available from: http://etd.cput.ac.za/handle/20.500.11838/1487

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

23. Cates- Gatto, Chelsea. Effects of Zinc on Ethanol Drinking, Behavior, and Oxidative Stress Following Chronic Intermittent Ethanol Exposure .

Degree: 2013, California State University – San Marcos

URL: http://hdl.handle.net/10211.8/419

► The negative effects associated with increased alcohol consumption have been well documented, and include increased risk for depression, anxiety, sleep disorders, stroke, heart disease, certain… (more)

Subjects/Keywords: Ethanol; oxidative stress; mouse; behavior

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APA (6^th Edition):

Cates- Gatto, C. (2013). Effects of Zinc on Ethanol Drinking, Behavior, and Oxidative Stress Following Chronic Intermittent Ethanol Exposure . (Thesis). California State University – San Marcos. Retrieved from http://hdl.handle.net/10211.8/419

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cates- Gatto, Chelsea. “Effects of Zinc on Ethanol Drinking, Behavior, and Oxidative Stress Following Chronic Intermittent Ethanol Exposure .” 2013. Thesis, California State University – San Marcos. Accessed February 27, 2020. http://hdl.handle.net/10211.8/419.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cates- Gatto, Chelsea. “Effects of Zinc on Ethanol Drinking, Behavior, and Oxidative Stress Following Chronic Intermittent Ethanol Exposure .” 2013. Web. 27 Feb 2020.

Vancouver:

Cates- Gatto C. Effects of Zinc on Ethanol Drinking, Behavior, and Oxidative Stress Following Chronic Intermittent Ethanol Exposure . [Internet] [Thesis]. California State University – San Marcos; 2013. [cited 2020 Feb 27]. Available from: http://hdl.handle.net/10211.8/419.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cates- Gatto C. Effects of Zinc on Ethanol Drinking, Behavior, and Oxidative Stress Following Chronic Intermittent Ethanol Exposure . [Thesis]. California State University – San Marcos; 2013. Available from: http://hdl.handle.net/10211.8/419

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

UCLA

24. Berquist, Sean. Sound Production in the Isolated Mouse Larynx.

Degree: Physiological Science, 2013, UCLA

URL: http://www.escholarship.org/uc/item/0hr2b5x5

► Recent evidence indicates that laboratory mice use elaborate ultrasonic songs, and this behavior possibly may be learned. In the present study, air pressure was manipulated… (more)

Subjects/Keywords: Physiology; larynx; mouse; phonation

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APA (6^th Edition):

Berquist, S. (2013). Sound Production in the Isolated Mouse Larynx. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/0hr2b5x5

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Berquist, Sean. “Sound Production in the Isolated Mouse Larynx.” 2013. Thesis, UCLA. Accessed February 27, 2020. http://www.escholarship.org/uc/item/0hr2b5x5.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Berquist, Sean. “Sound Production in the Isolated Mouse Larynx.” 2013. Web. 27 Feb 2020.

Vancouver:

Berquist S. Sound Production in the Isolated Mouse Larynx. [Internet] [Thesis]. UCLA; 2013. [cited 2020 Feb 27]. Available from: http://www.escholarship.org/uc/item/0hr2b5x5.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Berquist S. Sound Production in the Isolated Mouse Larynx. [Thesis]. UCLA; 2013. Available from: http://www.escholarship.org/uc/item/0hr2b5x5

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Southern California

25. Liu, Baohua. Cortical synaptic circuitry underlying visual processing in the primary visual cortex.

Degree: PhD, Physiology & Biophysics, 2010, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/313409/rec/1669

► The simple-cell receptive field (RF) structure is an attractive and unique feature of the primary visual cortex, which is thought to reflect the circuitry principles… (more)

▼ The simple-cell receptive field (RF) structure is an attractive and unique feature of the primary visual cortex, which is thought to reflect the circuitry principles governing orientation selectivity. Synaptic inputs underlying spike RFs are key to understanding mechanisms for neuronal processing. The well-known push-pull model, which is proposed to explain the synaptic mechanism under simple-cell RFs, predicts that in simple cells the spatially separated excitation and inhibition does not interact with each other and that simple inhibitory neurons exist in the primary visual cortex (V1). However, previous experimental results suggest that synaptic inhibition plays an important role in shaping RF properties in the visual cortex. The synaptic mechanisms underlying simple-cell RFs remain not well understood, partly due to difficulties in systematically studying functional properties of cortical inhibitory neurons and precisely measuring excitatory and inhibitory synaptic inputs in vivo.; In the first part of this project, to explore the functional properties of inhibitory neurons, we established two-photon imaging targeted cell-attached recordings from genetically labeled inhibitory neurons and nearby “shadowed” excitatory neurons in the primary visual cortex of adult mice. We found that in layer 2/3 the majority of excitatory neurons exhibited both On and Off spike subfields, with their spatial arrangement varying from being completely segregated to overlapped. On the other hand, most layer 4 excitatory neurons exhibited only one discernable subfield. Interestingly, no RF structure with significantly segregated On and Off subfields was observed for layer 2/3 inhibitory neurons of either the fast-spike or regular-spike type. They predominantly possessed overlapped On and Off subfields with a significantly larger size than the excitatory neurons, and exhibited much weaker orientation tuning. These results suggest that different from the push-pull model of simple cells, layer 2/3 simple-type neurons with segregated spike On and Off subfields likely receive spatially overlapped inhibitory On and Off inputs, which can enhance the spatial distinctiveness of On and Off subfields through a gain control mechanism.; In the second part, to explore the synaptic mechanism underlying simple cells, we applied whole-cell voltage-clamp recordings to mouse V1 neurons to reveal the spatial patterns of their excitatory and inhibitory synaptic inputs evoked by On and Off stimuli. Surprisingly, neurons with either segregated or overlapped On/Off spike subfields exhibited substantial overlaps between all the four synaptic subfields. The segregated RF structures are generated by the integration of excitation and inhibition with a stereotypic pattern: the peaks of excitatory On/Off subfields are separated and flank co-localized peaks of inhibitory On/Off subfields. The small mismatch of excitation/inhibition leads to an asymmetric inhibitory shaping of On/Off spatial tunings, resulting in a great enhancement of their distinctiveness. Thus,… Advisors/Committee Members: Zhang, Li I. (Committee Chair), Sampath, Alapakkam P. (Committee Member), Chen, Jeannie (Committee Member), Chow, Robert HP. (Committee Member), Farley, Robert A. (Committee Member).

Subjects/Keywords: mouse; interneuron; excitation; inhibition; vision

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APA (6^th Edition):

Liu, B. (2010). Cortical synaptic circuitry underlying visual processing in the primary visual cortex. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/313409/rec/1669

Chicago Manual of Style (16^th Edition):

Liu, Baohua. “Cortical synaptic circuitry underlying visual processing in the primary visual cortex.” 2010. Doctoral Dissertation, University of Southern California. Accessed February 27, 2020. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/313409/rec/1669.

MLA Handbook (7^th Edition):

Liu, Baohua. “Cortical synaptic circuitry underlying visual processing in the primary visual cortex.” 2010. Web. 27 Feb 2020.

Vancouver:

Liu B. Cortical synaptic circuitry underlying visual processing in the primary visual cortex. [Internet] [Doctoral dissertation]. University of Southern California; 2010. [cited 2020 Feb 27]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/313409/rec/1669.

Council of Science Editors:

Liu B. Cortical synaptic circuitry underlying visual processing in the primary visual cortex. [Doctoral Dissertation]. University of Southern California; 2010. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/313409/rec/1669

Virginia Tech

26. Meaney, Mary Patricia. The growth of murine breast cancer cells in dystrophic mice.

Degree: PhD, Human Nutrition, Foods, and Exercise, 2011, Virginia Tech

URL: http://hdl.handle.net/10919/40177

► The American Cancer Society predicted that 230,480 women would be diagnosed with, and 39,520 women would die from breast cancer (BC) in the United States… (more)

▼ The American Cancer Society predicted that 230,480 women would be diagnosed with, and 39,520 women would die from breast cancer (BC) in the United States in 2011. While the incidence of female BC has been decreasing, BC remains the second leading cause of cancer death among women in the United States. Cancer cachexia, the cancer-related loss of muscle, affects up to 25% of BC patients and is associated with poor prognosis and decreased quality of life. Alterations to the dystrophin glycoprotein complex (DGC), a transmembrane, multi-subunit protein complex with structural and signaling roles, have been reported in mammary tumors of BC patients and skeletal muscles of cachectic cancer patients. However, this complex is most frequently studied for its role in Duchenne muscular dystrophy (DMD), a severe, progressive muscle wasting disease. Despite the similar alterations reported in these diseases, it is unclear whether alterations in the DGC in one tissue can impact the progression of disease in another. Purpose: The purpose of the studies described in this dissertation was to identify differences in body composition, energy expenditure and plasma cytokine content between the C57BL/10ScSn-Dmdmdx/J (mdx) mouse model of DMD and C57BL/10ScSnJ (BL/10) control mice and to determine whether systemic alteration of the DGC (as observed in the mdx mouse) alters the growth of E0771 murine mammary tumors. Results: There were differences in body composition and plasma cytokine profiles between mdx and BL/10 mice. We also found that, relative to controls, the tumorâ induced increase in cytokines that promote invasion and metastasis was not as severe in mdx mice. Conclusions: This study revealed several differences between mdx and BL/10 mice and provides support for the suggestion that the mdx mouse may not be an accurate model of DMD. In addition, the improved cytokine profile of tumor-bearing mdx mice suggests that the acute phase of DMD may be protective against BC invasion and metastasis. Further research should confirm this effect and determine whether alterations in the DGC of the mdx mouse are directly or indirectly responsible. Advisors/Committee Members: Ju, Young H. (committeechair), Robertson, John L. (committee member), Escobar, Jeffery (committee member), Schmelz, Eva M. (committee member), Grange, Robert W. (committee member).

Subjects/Keywords: mdx mouse; cachexia; breast cancer

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APA (6^th Edition):

Meaney, M. P. (2011). The growth of murine breast cancer cells in dystrophic mice. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/40177

Chicago Manual of Style (16^th Edition):

Meaney, Mary Patricia. “The growth of murine breast cancer cells in dystrophic mice.” 2011. Doctoral Dissertation, Virginia Tech. Accessed February 27, 2020. http://hdl.handle.net/10919/40177.

MLA Handbook (7^th Edition):

Meaney, Mary Patricia. “The growth of murine breast cancer cells in dystrophic mice.” 2011. Web. 27 Feb 2020.

Vancouver:

Meaney MP. The growth of murine breast cancer cells in dystrophic mice. [Internet] [Doctoral dissertation]. Virginia Tech; 2011. [cited 2020 Feb 27]. Available from: http://hdl.handle.net/10919/40177.

Council of Science Editors:

Meaney MP. The growth of murine breast cancer cells in dystrophic mice. [Doctoral Dissertation]. Virginia Tech; 2011. Available from: http://hdl.handle.net/10919/40177

Cornell University

27. Ko, Frank. In Vivo Noninvasive Mouse Model Of Load Induced Osteoarthritis .

Degree: 2014, Cornell University

URL: http://hdl.handle.net/1813/37056

► Osteoarthritis (OA) is the leading cause of disability among the elderly population, affecting approximately 27 millions Americans and costing $60 billion in related-health care costs.… (more)

▼ Osteoarthritis (OA) is the leading cause of disability among the elderly population, affecting approximately 27 millions Americans and costing $60 billion in related-health care costs. Mouse models of OA have been developed to study the mechanisms of OA and therapeutic interventions. However, traditional animal models induce OA pathology through traumatic surgeries, which only represent 10% of human OA patients. Thus, in this thesis, a novel noninvasive OA mouse model was developed, characterized, and applied to transgenic mice. The changes in articular cartilage and subchondral bone were analyzed by histology, immunohistochemistry, and microcomputed tomography. To develop a noninvasive OA mouse model, an in vivo tibial loading model was used to investigate the adaptive responses of cartilage and bone to mechanical loading and to assess the influence of load level and duration. Peak cyclic compression of 4.5 and 9.0N was applied to the left tibia via the knee joint of adult (26-week-old) male mice for 1, 2, and 6 weeks at 1200 cycles/day. In addition, 9.0N loading was utilized in young (10-week-old) mice. Loading promoted cartilage damage, cartilage thinning, and subchondral cortical bone thickening in both age groups. Both age groups developed periarticular osteophytes at the tibial plateau in response to the 9.0N load, but no osteophyte formation occurred in adult mice subjected to 4.5N load. Development of a novel noninvasive loading model was followed by investigating the traumatic vs. nontraumatic nature of cyclic loading of the mouse knee joint. To differentiate traumatic tissue damage versus cell-mediated processes in the development of OA pathology, a single nondestructive 5-minute loading session was applied to the left tibia of adult (26-weekold) mice at a peak load of 9.0N. Knee joints were subsequently analyzed at 0, 1 and 2 weeks after loading. At T = 0, no change was evident in cartilage or subchondral bone. However, cartilage pathology demonstrated by localized thinning, proteoglycan loss, and inhibition of chondrocyte autophagy occurred at 1 and 2 weeks after the single session of loading. Transient cancellous bone loss was evident at 1 week, associated with increased osteoclast number, reversed at 2 weeks. Finally, the in vivo tibial loading model was implemented to study the role of Dickkopf1, an inhibitor of the Wnt pathway, in the development of load-induced OA. To identify the role of Dickkopf-1 protein in OA, novel viable mice with Dickkopf-1 knockout and Wnt3 knockdown (Dkk1-/-;Wnt3+/-) were used. The left tibia of 10-week-old Dkk1-/-;Wnt3+/- and respective control groups, littermate control (Dkk1+/+;Wnt3+/+) and Wnt3 knockdown (Dkk1+/+;Wnt3+/-) mice, underwent cyclic compression at a peak load of 9.0N for 2 weeks. As a result of loading, both Dkk1-/-;Wnt3+/- and Dkk1+/+;Wnt3+/+ mice demonstrated cartilage erosion, subchondral cancellous bone loss, and osteophyte formation. However, Dkk1+/+;Wnt3+/- mice did not undergo cartilage degeneration and showed limited osteophyte formation, indicating… Advisors/Committee Members: Hernandez, Christopher J. (committeeMember), Farnum, Cornelia E (committeeMember), Wright, Timothy M. (committeeMember).

Subjects/Keywords: Osteoarthritis; Mouse model; Mechanical loading

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APA (6^th Edition):

Ko, F. (2014). In Vivo Noninvasive Mouse Model Of Load Induced Osteoarthritis . (Thesis). Cornell University. Retrieved from http://hdl.handle.net/1813/37056

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ko, Frank. “In Vivo Noninvasive Mouse Model Of Load Induced Osteoarthritis .” 2014. Thesis, Cornell University. Accessed February 27, 2020. http://hdl.handle.net/1813/37056.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ko, Frank. “In Vivo Noninvasive Mouse Model Of Load Induced Osteoarthritis .” 2014. Web. 27 Feb 2020.

Vancouver:

Ko F. In Vivo Noninvasive Mouse Model Of Load Induced Osteoarthritis . [Internet] [Thesis]. Cornell University; 2014. [cited 2020 Feb 27]. Available from: http://hdl.handle.net/1813/37056.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ko F. In Vivo Noninvasive Mouse Model Of Load Induced Osteoarthritis . [Thesis]. Cornell University; 2014. Available from: http://hdl.handle.net/1813/37056

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Colorado

28. Maranjian, Kayla Jean. Mechanical and material property changes in bone with experimental diabetes: a murine model.

Degree: MS, Mechanical Engineering, 2011, University of Colorado

URL: https://scholar.colorado.edu/mcen_gradetds/28

► Over 23 million people in the United States are plagued by diabetes mellitus. Studies have shown that those with diabetes have a higher occurrence… (more)

▼ Over 23 million people in the United States are plagued by diabetes mellitus. Studies have shown that those with diabetes have a higher occurrence of bone fractures than those without the disease, but risk factors associated with diabetes account for only a portion of these fractures (Schwartz 2003; Vestergaard 2006). This implies that there are properties of diabetic bones that account for this increase in fractures. Research has been performed on the bone mineral density (BMD) of those with and without diabetes. However, studying this singular property of bones does not fully explain the increase in bone fractures in the diabetic population. Additionally, this research has yielded inconclusive results: some studies show that diabetes leads to an increase in BMD while others show a decrease in this property (Krakauer et al. 1995; Retzepi & Donos 2010). The objective of this study is to analyze the effect of experimental diabetes on bone properties in mice. This relationship is explored through analyzing different mouse strains to determine a potential genetic link, kidney removal to mimic the effects of nephropathy, and an LXR agonist to explore a potential diabetes treatment. We hypothesize that diabetes will negatively impact bone properties across multiple strains of mice, kidney removal will further degrade bone properties and the LXR agonist will improve some of the negative bone effects that diabetes causes. In general, STZ-induced diabetes was accompanied by decreases in physical and compositional bone properties in both strains of mice. Kidney removal and treatment with an LXR-agonist had little to no effects on these bone properties. Kidney removal was performed in skeletally mature mice; this old age may have contributed to the lack of effects. Similarly, the LXR agonist was administered over a short time period, and the detrimental effects from the diabetes were not able to be overcome. The data presented here provides evidence that experimentally-induced diabetes corresponds with a decrease in bone properties and nephropathy. While LXR agonists hold promise for mitigating bone property changes in diabetes, further analysis is required to determine their potential effects. Advisors/Committee Members: Virginia L. Ferguson, Mark Rentschler, Karen, King.

Subjects/Keywords: Biomedical; Bone; Mouse; Mechanical Engineering

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APA (6^th Edition):

Maranjian, K. J. (2011). Mechanical and material property changes in bone with experimental diabetes: a murine model. (Masters Thesis). University of Colorado. Retrieved from https://scholar.colorado.edu/mcen_gradetds/28

Chicago Manual of Style (16^th Edition):

Maranjian, Kayla Jean. “Mechanical and material property changes in bone with experimental diabetes: a murine model.” 2011. Masters Thesis, University of Colorado. Accessed February 27, 2020. https://scholar.colorado.edu/mcen_gradetds/28.

MLA Handbook (7^th Edition):

Maranjian, Kayla Jean. “Mechanical and material property changes in bone with experimental diabetes: a murine model.” 2011. Web. 27 Feb 2020.

Vancouver:

Maranjian KJ. Mechanical and material property changes in bone with experimental diabetes: a murine model. [Internet] [Masters thesis]. University of Colorado; 2011. [cited 2020 Feb 27]. Available from: https://scholar.colorado.edu/mcen_gradetds/28.

Council of Science Editors:

Maranjian KJ. Mechanical and material property changes in bone with experimental diabetes: a murine model. [Masters Thesis]. University of Colorado; 2011. Available from: https://scholar.colorado.edu/mcen_gradetds/28

Cornell University

29. Pattabiraman, Shrivatsav. Brwd1, A Ubiquitously Expressed Gene, Has Non Redundant Sexually Dimorphic Functions In The Mammalian Germlinepage .

Degree: 2014, Cornell University

URL: http://hdl.handle.net/1813/36178

► Normal spermiogenesis requires the transcription of many genes that occurs exclusively after meiosis. This wave of transcriptional changes in haploid spermatids is well-documented, but the… (more)

Subjects/Keywords: brwd1; fertility; mouse; transcription; spermiogenesis

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APA (6^th Edition):

Pattabiraman, S. (2014). Brwd1, A Ubiquitously Expressed Gene, Has Non Redundant Sexually Dimorphic Functions In The Mammalian Germlinepage . (Thesis). Cornell University. Retrieved from http://hdl.handle.net/1813/36178

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pattabiraman, Shrivatsav. “Brwd1, A Ubiquitously Expressed Gene, Has Non Redundant Sexually Dimorphic Functions In The Mammalian Germlinepage .” 2014. Thesis, Cornell University. Accessed February 27, 2020. http://hdl.handle.net/1813/36178.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pattabiraman, Shrivatsav. “Brwd1, A Ubiquitously Expressed Gene, Has Non Redundant Sexually Dimorphic Functions In The Mammalian Germlinepage .” 2014. Web. 27 Feb 2020.

Vancouver:

Pattabiraman S. Brwd1, A Ubiquitously Expressed Gene, Has Non Redundant Sexually Dimorphic Functions In The Mammalian Germlinepage . [Internet] [Thesis]. Cornell University; 2014. [cited 2020 Feb 27]. Available from: http://hdl.handle.net/1813/36178.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pattabiraman S. Brwd1, A Ubiquitously Expressed Gene, Has Non Redundant Sexually Dimorphic Functions In The Mammalian Germlinepage . [Thesis]. Cornell University; 2014. Available from: http://hdl.handle.net/1813/36178

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Melbourne

30. Witkowski, Matthew Tadeusz Antoni. Reversible tumour suppression by Ikaros in mouse models of acute lymphoblastic leukaemia.

Degree: 2015, University of Melbourne

URL: http://hdl.handle.net/11343/55328

► Mutations reducing the function of haematopoietic transcription factor IKAROS (encoded by IKZF1) occur in distinct subsets of human B-cell progenitor acute lymphoblastic leukaemia (B-ALL) cases… (more)

▼ Mutations reducing the function of haematopoietic transcription factor IKAROS (encoded by IKZF1) occur in distinct subsets of human B-cell progenitor acute lymphoblastic leukaemia (B-ALL) cases and T-cell progenitor ALL (T-ALL) cases. Interestingly, IKZF1 mutations are particularly enriched in high-risk ALL subtypes, such as Ph+ B-ALL and Ph-like B-ALL, and confer resistance to chemotherapy. Despite this, there is little mechanistic understanding of how IKZF1 mutations confer such poor prognosis. This thesis describes a novel mouse model used to investigate the molecular mechanisms through which Ikaros hypomorphism contributes to ALL pathogenesis and therapy resistance. We have generated a novel transgenic mouse allowing inducible Ikaros knockdown throughout the haematopoietic compartment in vivo and demonstrate knockdown can effectively disable the tumour suppressive function of Ikaros in the T- and B-cell lineages. Using this approach, endogenous Ikaros expression can be inducibly restored within established leukaemia in vivo, providing novel insights into Ikaros function in T- and B-ALL in vivo and allowing identification of high-confidence Ikaros target genes using RNA-Seq. In Chapter Three and Chapter Four, we use our mouse model to investigate how Ikaros hypomorphism contributes to T-ALL. In Chapter Three, we show Ikaros restoration induces a glucocorticoid(GC)-response signature in T-ALL in vivo and functionally demonstrate a previously unappreciated role for Ikaros in pre-receptor GC activation. In Chapter Four, we find that Ikaros restoration represses Notch1 and its oncogenic target genes including Myc, leading to disease regression in multiple primary T-ALLs. In contrast, leukaemias expressing high levels of activated intracellular Notch1 (ICN1) resembling those found in human T-ALL rapidly relapse following Ikaros restoration, indicating that ICN1 functionally antagonizes Ikaros in established disease. Furthermore, we show that IKAROS mRNA expression is negatively regulated by activated NOTCH1 in human T-ALL cell lines, demonstrating for the first time that aberrant NOTCH activity compromises IKAROS function in mouse and human T-ALL. In Chapter Five, we demonstrate Ikaros knockdown accelerates Ph+ B-ALL development, and Ikaros restoration in established disease is required for tumour cell survival in vivo. Using RNA-Seq analysis of primary murine Ph+ B-ALL, we define a series of high-confidence murine Ikaros-activated and Ikaros-repressed genes. We then compared Ikaros-regulated genes in murine Ph+ B-ALL to IKAROS-activated and IKAROS-repressed genes derived from primary human B-ALL RNA-Seq data, and find a set of conserved IKAROS-regulated genes. Functional validation of these conserved Ikaros-regulated genes may pro-vide novel insights into the role of IKAROS mutations in high-risk B-ALL pathogenesis and therapy resistance.

Subjects/Keywords: leukaemia; Ikaros; acute; lymphoblastic; mouse

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APA (6^th Edition):

Witkowski, M. T. A. (2015). Reversible tumour suppression by Ikaros in mouse models of acute lymphoblastic leukaemia. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/55328

Chicago Manual of Style (16^th Edition):

Witkowski, Matthew Tadeusz Antoni. “Reversible tumour suppression by Ikaros in mouse models of acute lymphoblastic leukaemia.” 2015. Doctoral Dissertation, University of Melbourne. Accessed February 27, 2020. http://hdl.handle.net/11343/55328.

MLA Handbook (7^th Edition):

Witkowski, Matthew Tadeusz Antoni. “Reversible tumour suppression by Ikaros in mouse models of acute lymphoblastic leukaemia.” 2015. Web. 27 Feb 2020.

Vancouver:

Witkowski MTA. Reversible tumour suppression by Ikaros in mouse models of acute lymphoblastic leukaemia. [Internet] [Doctoral dissertation]. University of Melbourne; 2015. [cited 2020 Feb 27]. Available from: http://hdl.handle.net/11343/55328.

Council of Science Editors:

Witkowski MTA. Reversible tumour suppression by Ikaros in mouse models of acute lymphoblastic leukaemia. [Doctoral Dissertation]. University of Melbourne; 2015. Available from: http://hdl.handle.net/11343/55328

Open Access Theses and Dissertations