subject:(motor symptoms)

University of Tasmania

1. Green, L. Investigating the effects of motor symptoms on the development and assessment of non-motor symptoms in idiopathic Parkinson's disease.

Degree: 2014, University of Tasmania

URL: https://eprints.utas.edu.au/18642/1/Whole-Green-thesis.pdf ; https://eprints.utas.edu.au/18642/4/List%20of%20Appendices.pdf ; https://eprints.utas.edu.au/18642/5/Appendix%20A.zip ; https://eprints.utas.edu.au/18642/6/Appendix%20B.zip ; https://eprints.utas.edu.au/18642/7/Appendix%20C%20%282%29.zip

► Parkinson’s disease (PD) is a degenerative sub-cortical neurological disorder primarily involving morphologic and neurochemical changes in the human brain, particularly the basal ganglia. Basal ganglia… (more)

▼ Parkinson’s disease (PD) is a degenerative sub-cortical neurological disorder primarily involving morphologic and neurochemical changes in the human brain, particularly the basal ganglia. Basal ganglia is a term used to identify areas of the basal forebrain and midbrain known to be involved in the control of movement and some higher cortical functions. Cardinal motor symptoms in PD include muscle rigidity, tremor, bradykinesia, a loss of postural reflexes and, in extreme cases, akinesia. These symptoms can be experienced either unilaterally or bilaterally. Non-motor symptoms in PD include cognitive decline, depression, sleep disturbances, hallucinations, and apathy. Changes in cognitive functioning in PD can range from mild cognitive impairment to Parkinson's disease dementia (PDD). While studies investigating a potential relationship between motor symptom phenotype and cognitive decline in PD exist, results have been equivocal to date. Additional research has been recommended and this was the aim of the current studies. Participants (n = 88) were recruited from the Royal Hobart Hospital and administered a comprehensive assessment battery that included demographic and mood measures, a range of cognitive measures covering immediate and delayed memory, executive functioning, visuospatial functioning, and language, as well as several tests of motor functioning. Study One examined the link between current motor functioning and cognitive performance. Despite no significant between groups differences on demographic variables such as age, years of education, pre-morbid cognitive functioning, mood, and disease duration, participants in the lower motor functioning group consistently performed more poorly on all cognitive tasks included in the assessment battery. Study Two examined the impact of side of motor symptom onset, comparing the current cognitive functioning of participants who experience left sided, right sided, or bilateral motor symptoms at time of initial diagnosis. While no significant differences were found between those with left sided and right sided motor symptom onset, those with bilateral motor symptom onset were significantly (p < .001) more likely to achieve the poorest cognitive results. Study Three examined the potentially confounding impact of motor functioning and side of onset when assessing anxiety and depression in a PD population using the two-factor Hospital Anxiety and Depression Scale (HADS) as well as a three-factor model of the HADS that separated anxiety, depression, and psychomotor symptoms. Results cautioned against reliance on the traditional HADS for detecting mood symptoms in people with PD. Overall results indicate that motor symptom presentation can provide valuable information regarding cognitive functioning and mood in PD populations.

Subjects/Keywords: motor; non-motor; symptoms; Parkinson's disease; assessment

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APA (6^th Edition):

Green, L. (2014). Investigating the effects of motor symptoms on the development and assessment of non-motor symptoms in idiopathic Parkinson's disease. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/18642/1/Whole-Green-thesis.pdf ; https://eprints.utas.edu.au/18642/4/List%20of%20Appendices.pdf ; https://eprints.utas.edu.au/18642/5/Appendix%20A.zip ; https://eprints.utas.edu.au/18642/6/Appendix%20B.zip ; https://eprints.utas.edu.au/18642/7/Appendix%20C%20%282%29.zip

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Green, L. “Investigating the effects of motor symptoms on the development and assessment of non-motor symptoms in idiopathic Parkinson's disease.” 2014. Thesis, University of Tasmania. Accessed January 17, 2021. https://eprints.utas.edu.au/18642/1/Whole-Green-thesis.pdf ; https://eprints.utas.edu.au/18642/4/List%20of%20Appendices.pdf ; https://eprints.utas.edu.au/18642/5/Appendix%20A.zip ; https://eprints.utas.edu.au/18642/6/Appendix%20B.zip ; https://eprints.utas.edu.au/18642/7/Appendix%20C%20%282%29.zip.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Green, L. “Investigating the effects of motor symptoms on the development and assessment of non-motor symptoms in idiopathic Parkinson's disease.” 2014. Web. 17 Jan 2021.

Vancouver:

Green L. Investigating the effects of motor symptoms on the development and assessment of non-motor symptoms in idiopathic Parkinson's disease. [Internet] [Thesis]. University of Tasmania; 2014. [cited 2021 Jan 17]. Available from: https://eprints.utas.edu.au/18642/1/Whole-Green-thesis.pdf ; https://eprints.utas.edu.au/18642/4/List%20of%20Appendices.pdf ; https://eprints.utas.edu.au/18642/5/Appendix%20A.zip ; https://eprints.utas.edu.au/18642/6/Appendix%20B.zip ; https://eprints.utas.edu.au/18642/7/Appendix%20C%20%282%29.zip.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Green L. Investigating the effects of motor symptoms on the development and assessment of non-motor symptoms in idiopathic Parkinson's disease. [Thesis]. University of Tasmania; 2014. Available from: https://eprints.utas.edu.au/18642/1/Whole-Green-thesis.pdf ; https://eprints.utas.edu.au/18642/4/List%20of%20Appendices.pdf ; https://eprints.utas.edu.au/18642/5/Appendix%20A.zip ; https://eprints.utas.edu.au/18642/6/Appendix%20B.zip ; https://eprints.utas.edu.au/18642/7/Appendix%20C%20%282%29.zip

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Boston University

2. Salazar, Robert. Interactions of motor and non-motor symptoms in Parkinson's disease.

Degree: PhD, Psychological & Brain Sciences, 2019, Boston University

URL: http://hdl.handle.net/2144/39849

► Parkinson’s disease (PD) is characterized by motor dysfunction and multiple non-motor symptoms. Though motor/non-motor interactions are common, the lines of research focusing on motor and… (more)

Subjects/Keywords: Clinical psychology; Anxiety; Executive function; Motor symptoms; Non-motor symptoms; Parkinson's disease; Stigma

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APA (6^th Edition):

Salazar, R. (2019). Interactions of motor and non-motor symptoms in Parkinson's disease. (Doctoral Dissertation). Boston University. Retrieved from http://hdl.handle.net/2144/39849

Chicago Manual of Style (16^th Edition):

Salazar, Robert. “Interactions of motor and non-motor symptoms in Parkinson's disease.” 2019. Doctoral Dissertation, Boston University. Accessed January 17, 2021. http://hdl.handle.net/2144/39849.

MLA Handbook (7^th Edition):

Salazar, Robert. “Interactions of motor and non-motor symptoms in Parkinson's disease.” 2019. Web. 17 Jan 2021.

Vancouver:

Salazar R. Interactions of motor and non-motor symptoms in Parkinson's disease. [Internet] [Doctoral dissertation]. Boston University; 2019. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/2144/39849.

Council of Science Editors:

Salazar R. Interactions of motor and non-motor symptoms in Parkinson's disease. [Doctoral Dissertation]. Boston University; 2019. Available from: http://hdl.handle.net/2144/39849

Univerzitet u Beogradu

3. Petrović, Mirjana D., 1973-. Dugoročno praćenje motornih i nemotornih simptoma u Parkinsonovoj bolesti.

Degree: Medicinski fakultet, 2018, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:15309/bdef:Content/get

►

medicina - neurologija / Medicine - Neurology

Uvod: Parkinsonova bolest (PB) predstavlja progresivno neurodegenerativno oboljenje, prosečne dužine trajanja od oko 15 godina, koje se klinički… (more)

▼

medicina - neurologija / Medicine - Neurology

Uvod: Parkinsonova bolest (PB) predstavlja progresivno neurodegenerativno oboljenje, prosečne dužine trajanja od oko 15 godina, koje se klinički ispoljava motornim i čitavim spektrom nemotornih manifestacija. Progresija same bolesti je strogo individualna, veoma heterogena i značajno brža u početnim stadijumima bolesti (Hoehn and Yarh (HiY) stadijumima 1-2) i sa trajanjem bolesti postaje sporija (HiY stadijumi 3-5). Najčešći neuropsihijatrijski poremećaji u pacijenata sa PB su apatija, depresija i anksioznost. Demencija u PB predstavlja 3- 4% svih degenerativnih demencija. Kumulativna prevalenca demencije u PB je velika i oko 80% pacijenata razvije demenciju nakon 10 godina trajanja bolesti. Cilj: Utvrditi stepen progresije motornih manifestacija bolesti u petogodišnjem intervalu praćenja u pacijenata sa PB u odnosu na kliničku formu bolesti ali i u korelaciji sa nemotornim manifestacijama bolesti i utvrditi stepen progresije nemotornih manifestacija bolesti u petogodišnjem intervalu praćenja pacijenata sa PB i njihov značaj u lečenju, kao i uticaj na kvalitet života obolelih. Metode: Uzorak ispitanika čini 3θ0 pacijenata sa dijagnozom Parkinsonove bolesti postavljene prema kriterijumima- UK Parkinson’s disease Society Brain Bank Criteria koji su pregledani u periodu od 01.01.2004. do 31.12. 2008. godine i sa praćenjem toka bolesti istih u narednom petogodišnjem intervalu. Praćenje progresije motornih simptoma podrazumevalo je primenu Unifikovane skale za procenu Parkinsonove bolesti kao i utvrđivanje Hoehn i Yarh stadijuma bolesti; praćenje nemotornih simptoma PB podrazumevalo je procenu poremećaja raspoloženja i ponašanja primenom Marinove Skale apatije, Hamiltonove skale anksioznosti i Hamiltonove skale depresivnosti, dok je u cilju procene kognitivnog statusa pacijenata primenjen Mini- Mental test i Klinička skala za procenu demencije...

Advisors/Committee Members: Stefanova, Elka, 1959-.

Subjects/Keywords: Parkinson's disease; motor and non-motor symptoms in PD; mortality

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APA (6^th Edition):

Petrović, Mirjana D., 1. (2018). Dugoročno praćenje motornih i nemotornih simptoma u Parkinsonovoj bolesti. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:15309/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Petrović, Mirjana D., 1973-. “Dugoročno praćenje motornih i nemotornih simptoma u Parkinsonovoj bolesti.” 2018. Thesis, Univerzitet u Beogradu. Accessed January 17, 2021. https://fedorabg.bg.ac.rs/fedora/get/o:15309/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Petrović, Mirjana D., 1973-. “Dugoročno praćenje motornih i nemotornih simptoma u Parkinsonovoj bolesti.” 2018. Web. 17 Jan 2021.

Vancouver:

Petrović, Mirjana D. 1. Dugoročno praćenje motornih i nemotornih simptoma u Parkinsonovoj bolesti. [Internet] [Thesis]. Univerzitet u Beogradu; 2018. [cited 2021 Jan 17]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:15309/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Petrović, Mirjana D. 1. Dugoročno praćenje motornih i nemotornih simptoma u Parkinsonovoj bolesti. [Thesis]. Univerzitet u Beogradu; 2018. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:15309/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University College Cork

4. Dolan, Erin. Non-motor symptoms in the aav-α-synuclein rat model of Parkinson’s disease: exercise as a therapeutic intervention.

Degree: 2017, University College Cork

URL: http://hdl.handle.net/10468/6623

► Parkinson’s disease (PD) is no longer primarily classified as a motor disorder due to the emergence of a number of non-motor symptoms (NMS) of the… (more)

▼ Parkinson’s disease (PD) is no longer primarily classified as a motor disorder due to the emergence of a number of non-motor symptoms (NMS) of the disease. These NMS are highly prevalent and greatly affect the quality of life of patients with PD. Thus, an animal model that replicates these symptoms is greatly needed to enhance the translational impact of preclinical research. The AAV-α-synuclein rat model is the only animal model to date that has been shown to robustly and consistently reproduce the primary neuropathological and behavioural features of PD. However, there has been little research on the ability of the model to replicate NMS of the disease. Moreover, this model is most commonly employed unilaterally, which can confound cognitive testing due to contralateral functional compensation. Thus, the aim of this thesis was to use an AAV2/6 viral vector overexpressing human wild-type α-synuclein to characterise NMS of PD, exploring behavioural phenotypes of both unilaterally- and bilaterally-administered αsynuclein. Furthermore, it set out to explore whether voluntary exercise could ameliorate motor and NMS in this PD model, including if exercise could protect against hippocampal-associated cognitive deficits by modulating adult hippocampal neurogenesis. We demonstrated that unilateral and bilateral administration of AAV-αsynuclein induced distinct patterns of nigrostriatal degeneration and associated motor dysfunction. Overexpression of AAV-α-synuclein was used to model NMS associated with PD, including deficits in hippocampalassociated tasks. This was coupled with α-synuclein-positive immunostaining in the dentate gyrus of the hippocampus, confirming the propagation of the protein throughout distinct regions of the brain. Bilateral intranigral administration of AAV-α-synuclein was found to induce motor dysfunction and a significant loss of nigral dopaminergic neurons, neither of which were rescued by voluntary running. Overexpression of α-synuclein also resulted in significant impairment on a neurogenesis-dependent pattern separation task, as well as anxiety-like behaviours on both the open field and the elevated plus maze. Voluntary running improved performance on the pattern separation task only. This was substantiated by an effect on hippocampal neurogenesis levels in the dorsal, and not ventral, dentate gyrus, suggesting that the functional effects on pattern separation were mediated by increasing neurogenesis. Advisors/Committee Members: Sullivan, Aideen M., Nolan, Yvonne M..

Subjects/Keywords: Parkinson's disease; Alpha-synuclein; Non-motor symptoms; Exercise

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APA (6^th Edition):

Dolan, E. (2017). Non-motor symptoms in the aav-α-synuclein rat model of Parkinson’s disease: exercise as a therapeutic intervention. (Thesis). University College Cork. Retrieved from http://hdl.handle.net/10468/6623

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dolan, Erin. “Non-motor symptoms in the aav-α-synuclein rat model of Parkinson’s disease: exercise as a therapeutic intervention.” 2017. Thesis, University College Cork. Accessed January 17, 2021. http://hdl.handle.net/10468/6623.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dolan, Erin. “Non-motor symptoms in the aav-α-synuclein rat model of Parkinson’s disease: exercise as a therapeutic intervention.” 2017. Web. 17 Jan 2021.

Vancouver:

Dolan E. Non-motor symptoms in the aav-α-synuclein rat model of Parkinson’s disease: exercise as a therapeutic intervention. [Internet] [Thesis]. University College Cork; 2017. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10468/6623.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dolan E. Non-motor symptoms in the aav-α-synuclein rat model of Parkinson’s disease: exercise as a therapeutic intervention. [Thesis]. University College Cork; 2017. Available from: http://hdl.handle.net/10468/6623

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Iowa State University

5. Zaman, Andrew. The effects of stress on working memory, inhibitory gating, and motor symptoms in Parkinson’s disease.

Degree: 2020, Iowa State University

URL: https://lib.dr.iastate.edu/etd/18253

► Parkinson's disease (PD) is a neurodegenerative disorder in which the substantia nigra has suffered a severe amount of cell loss, resulting in basal ganglia dysfunction.… (more)

Subjects/Keywords: Inhbitory Gating; Motor Symptoms; Parkinson's; Stress; UPDRS; Working Memory

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APA (6^th Edition):

Zaman, A. (2020). The effects of stress on working memory, inhibitory gating, and motor symptoms in Parkinson’s disease. (Thesis). Iowa State University. Retrieved from https://lib.dr.iastate.edu/etd/18253

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zaman, Andrew. “The effects of stress on working memory, inhibitory gating, and motor symptoms in Parkinson’s disease.” 2020. Thesis, Iowa State University. Accessed January 17, 2021. https://lib.dr.iastate.edu/etd/18253.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zaman, Andrew. “The effects of stress on working memory, inhibitory gating, and motor symptoms in Parkinson’s disease.” 2020. Web. 17 Jan 2021.

Vancouver:

Zaman A. The effects of stress on working memory, inhibitory gating, and motor symptoms in Parkinson’s disease. [Internet] [Thesis]. Iowa State University; 2020. [cited 2021 Jan 17]. Available from: https://lib.dr.iastate.edu/etd/18253.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zaman A. The effects of stress on working memory, inhibitory gating, and motor symptoms in Parkinson’s disease. [Thesis]. Iowa State University; 2020. Available from: https://lib.dr.iastate.edu/etd/18253

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Virginia Commonwealth University

6. Garroway, Andrea. Resilience in Parkinson’s disease: An empirical examination of age-related components of the construct.

Degree: PhD, Psychology, 2014, Virginia Commonwealth University

URL: https://doi.org/10.25772/07M8-2631 ; https://scholarscompass.vcu.edu/etd/3474

► Although Parkinson’s disease (PD) is commonly characterized by motor symptoms and physical limitations, there is growing recognition of nonmotor and mood symptoms associated with… (more)

▼ Although Parkinson’s disease (PD) is commonly characterized by motor symptoms and physical limitations, there is growing recognition of nonmotor and mood symptoms associated with the disease as well. There has been limited research exploring how individual coping might affect the relationships between PD symptoms and mental health outcomes. The resilience construct was originally developed within the child literature, and it is often used in conceptualizing how people have adaptive or positive outcomes when facing adversity. Current resilience measures may not adequately assess the construct within an older population, however, given the unique emotion regulation and coping skills seen in late life. This survey study of 139 community-dwelling adults with PD (M age = 64.25 years, SD = 10.12, range 34-89 years) investigated whether resilience moderated the relationship between PD-related factors (nonmotor symptoms, functional impairment, and disease symptom-related QOL) and mental health outcomes (depression, apathy, satisfaction with and adjustment-quality of life). Further analyses explored whether hypothesized age-related resilience components (optimism, goal-flexibility, and meaning-making ability), accounted for unique variance above and beyond a standard resilience measure (Resilience Scale for Adults). Results indicated that disease symptom-related QOL predicted depression and adjustment-related QOL, while functional impairment predicted apathy, life satisfaction, and adjustment related QOL. Participants overall reported moderate to high resilience; resilience was a significant predictor of all mental health/QOL outcome measures, and those with comparatively lower self-reported resilience had worse disease symptoms. Resilience did not moderate the relationship between disease symptoms and mental health/QOL. Meaning-making ability and goal-flexibility accounted for unique variance above and beyond the standard resilience measure for several outcome variables. Age was a significant moderator, such that the protective value of meaning-making ability and optimism on depression were greater for younger compared to older participants. This study highlighted the presence of moderate to high resilience in PD patients, however those with comparatively lower resilience had poorer outcomes. Other coping variables appear to be important contributors to mental health/QOL beyond a standard resilience measure. Patient age also affected several outcomes, emphasizing the importance of further integration of developmental literature into our understanding of resilience in chronic disease management. Advisors/Committee Members: Bruce Rybarczyk.

Subjects/Keywords: Resilience; Parkinson's disease; Depression; Apathy; Non-motor symptoms; Aging; Quality of life; Psychology

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APA (6^th Edition):

Garroway, A. (2014). Resilience in Parkinson’s disease: An empirical examination of age-related components of the construct. (Doctoral Dissertation). Virginia Commonwealth University. Retrieved from https://doi.org/10.25772/07M8-2631 ; https://scholarscompass.vcu.edu/etd/3474

Chicago Manual of Style (16^th Edition):

Garroway, Andrea. “Resilience in Parkinson’s disease: An empirical examination of age-related components of the construct.” 2014. Doctoral Dissertation, Virginia Commonwealth University. Accessed January 17, 2021. https://doi.org/10.25772/07M8-2631 ; https://scholarscompass.vcu.edu/etd/3474.

MLA Handbook (7^th Edition):

Garroway, Andrea. “Resilience in Parkinson’s disease: An empirical examination of age-related components of the construct.” 2014. Web. 17 Jan 2021.

Vancouver:

Garroway A. Resilience in Parkinson’s disease: An empirical examination of age-related components of the construct. [Internet] [Doctoral dissertation]. Virginia Commonwealth University; 2014. [cited 2021 Jan 17]. Available from: https://doi.org/10.25772/07M8-2631 ; https://scholarscompass.vcu.edu/etd/3474.

Council of Science Editors:

Garroway A. Resilience in Parkinson’s disease: An empirical examination of age-related components of the construct. [Doctoral Dissertation]. Virginia Commonwealth University; 2014. Available from: https://doi.org/10.25772/07M8-2631 ; https://scholarscompass.vcu.edu/etd/3474

University of Pretoria

7. Van Rensburg, Celestè-Mari. The Lurking Shadow : a qualitative study of the experience of residual symptoms following a violent crime.

Degree: MA, Psychology, 2014, University of Pretoria

URL: http://hdl.handle.net/2263/46115

► This research explores the beliefs and behaviour of individuals who have suffered a traumatic experience, specifically the violent crimes of assault, motor vehicle hijackings and… (more)

▼ This research explores the beliefs and behaviour of individuals who have suffered a traumatic experience, specifically the violent crimes of assault, motor vehicle hijackings and armed robbery. The researcher focuses on the occurrence of residual, subclinical symptoms of PTSD that individuals experience subsequent to the specified violent crimes. By identifying and describing trends in commonalities that exist between research participants’ accounts of such residual, subclinical symptoms the research aims to explore and describe these trends, enabling a common understanding and awareness of the longstanding effects that these experiences have on individuals. The qualitative research design allowed for an exploration aimed at understanding the meaning that individuals ascribe to specific events. Three case studies were examined. The researcher ensured the exclusion of individuals who met the criteria for PTSD by making use of the PCL-S. From this approach a thematic analysis was done using the transcriptions of audiotaped interviews with the participants. The three participants chosen for the study were aged twenty-nine (29), thirty (30) and thirty-one (31) independently. Two of the participants experienced an armed robbery, which were, independently, followed by non-violent crime of housebreaking and theft. A third participant experienced an armed robbery during her early childhood, and an additional crime of aggravated robbery in adulthood. The studied violent crimes had taken place between one year eleven months and six years prior to this study. None of the participants have received therapy following their traumatic experience. Five important findings were identified and discussed. Firstly, some individuals still meet the requirements for a diagnosis of PTSD, even years following their experiences with traumatic events. Secondly, following the experience of a violent crime some individual’s core cognitive schemas regarding themselves, their world and their relationships undergo various changes. Thirdly, some individuals experience numerous posttraumatic symptoms, which are not extensive enough to validate the diagnosis of PTSD, but that affect the individual’s life on a regular basis. Nine symptoms were identified in this study. Fourthly, some individuals may experience additional effects following exposure to violent crimes, e.g. physical illness, that is not classified as posttraumatic symptoms. Fifthly, a few individuals who have been the victim of more than one crime may experience cumulative or diminished effects when one explores the overall effects of revictimisation. Results also indicated that individuals may experiences similar posttraumatic symptoms, but that the presentation of these symptoms are unique and are influenced by an individual’s history, cognitive schemas and the characteristics of the crimes that they have experienced. Finally, these findings explored and described the phenomenon of partial posttraumatic stress disorder in order to expand the understanding of this occurrence. Advisors/Committee Members: Eskell-Blokland, Linda (advisor).

Subjects/Keywords: UCTD; PTSD (Posttraumatic Stress Disorder); Residual symptoms; Cognitive behavioural therapy; Violent crime; Motor vehicle hijack

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APA (6^th Edition):

Rensburg, Celestè-Mari, V. (2014). The Lurking Shadow : a qualitative study of the experience of residual symptoms following a violent crime. (Masters Thesis). University of Pretoria. Retrieved from http://hdl.handle.net/2263/46115

Chicago Manual of Style (16^th Edition):

Rensburg, Celestè-Mari, Van. “The Lurking Shadow : a qualitative study of the experience of residual symptoms following a violent crime.” 2014. Masters Thesis, University of Pretoria. Accessed January 17, 2021. http://hdl.handle.net/2263/46115.

MLA Handbook (7^th Edition):

Rensburg, Celestè-Mari, Van. “The Lurking Shadow : a qualitative study of the experience of residual symptoms following a violent crime.” 2014. Web. 17 Jan 2021.

Vancouver:

Rensburg, Celestè-Mari V. The Lurking Shadow : a qualitative study of the experience of residual symptoms following a violent crime. [Internet] [Masters thesis]. University of Pretoria; 2014. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/2263/46115.

Council of Science Editors:

Rensburg, Celestè-Mari V. The Lurking Shadow : a qualitative study of the experience of residual symptoms following a violent crime. [Masters Thesis]. University of Pretoria; 2014. Available from: http://hdl.handle.net/2263/46115

8. Leonardi, Giuseppa MAria Grazia. Acting as therapeutic support in Parkinson's disease. A Field experiment.

Degree: 2014, Università degli Studi di Catania

URL: http://hdl.handle.net/10761/1503

► In the past, the clinical approach to Parkinson s disease focussed primarily on motor symptoms, whereas the current trend emphasises the importance of non-motor symptoms,… (more)

Subjects/Keywords: Area 06 - Scienze mediche; Parkinson s disease, non-motor symptoms, acting therapy, rehabilitation.

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APA (6^th Edition):

Leonardi, G. M. G. (2014). Acting as therapeutic support in Parkinson's disease. A Field experiment. (Thesis). Università degli Studi di Catania. Retrieved from http://hdl.handle.net/10761/1503

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Leonardi, Giuseppa MAria Grazia. “Acting as therapeutic support in Parkinson's disease. A Field experiment.” 2014. Thesis, Università degli Studi di Catania. Accessed January 17, 2021. http://hdl.handle.net/10761/1503.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Leonardi, Giuseppa MAria Grazia. “Acting as therapeutic support in Parkinson's disease. A Field experiment.” 2014. Web. 17 Jan 2021.

Vancouver:

Leonardi GMG. Acting as therapeutic support in Parkinson's disease. A Field experiment. [Internet] [Thesis]. Università degli Studi di Catania; 2014. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10761/1503.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Leonardi GMG. Acting as therapeutic support in Parkinson's disease. A Field experiment. [Thesis]. Università degli Studi di Catania; 2014. Available from: http://hdl.handle.net/10761/1503

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New South Wales

9. Devenney, Emma. Clinical characteristics and psychiatric features of the C9orf72 expansion.

Degree: Prince of Wales Clinical School, 2016, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/59693 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:49363/SOURCE02?view=true

► This thesis aimed to contribute to the literature concerning the clinical characteristics of FTD, and in particular the link between psychosis, psychiatric disorders and the… (more)

▼ This thesis aimed to contribute to the literature concerning the clinical characteristics of FTD, and in particular the link between psychosis, psychiatric disorders and the C9orf72 expansion. Furthermore the thesis explored the relationship between the C9orf72 expansion, progression and the international diagnostic criteria for bvFTD. The finding that many of the C9orf72 carriers were initially considered to be phenocopy cases led to a clinicopathological study of this syndrome. Prominent psychotic symptoms were identified in C9orf72 carriers, which prompted further study of delusions and hallucinations in this genetic group and FTD patients as a whole, using standardized interviews and neuroimaging techniques. The results showed that psychotic symptoms are common in FTD-MND, and are particularly prevalent in C9orf72 carriers. A network of regional brain atrophy correlated with psychotic symptoms and these regions were strikingly similar to areas of atrophy in schizophrenia patients, which reinforced the theory that FTD and in particular the C9orf72 expansion is related to psychiatric disease. To explore this link further a family history interview was conducted in patients with FTD, MND and the C9orf72 expansion. The results showed that major psychiatric disorders occurred with significantly greater frequency in C9orf72 kindreds than kindreds without the C9orf72 expansion and that autism spectrum disorders (ASD) were more frequent in FTD, regardless of genotype, than in MND kindreds. Finally this thesis considered the frequency of psychotic symptoms acrossthe entire FTD-MND continuum, including for the first time those with pure MND, and identified a continuum of psychosis ranging from most markedin FTD-MND and bvFTD to least prevalent in pure MND. Nonetheless, psychotic symptoms were reported by 21% of pure MND patients;significantly more than the control population. This thesis then explored perceptual abnormalities across the continuum and considered the potential role of psychosocial factors in the expression of psychotic symptoms. This study identified an association between depression, social anxiety, social isolation, poor cognition and psychotic symptoms. Together this thesis has identified novel features of the C9orf72 expansion and provides a platform or further exploration of the links between psychiatric disease and the FTDMND continuum Advisors/Committee Members: Hodges, John, Prince of Wales Clinical School, Faculty of Medicine, UNSW, Kiernan, Matthew, Prince of Wales Clinical School, Faculty of Medicine, UNSW.

Subjects/Keywords: Clinical phenotype; Frontotemporal dementia; Motor neurone disease; C9orf72 genetic expansion; Psychiatric symptoms

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Devenney, E. (2016). Clinical characteristics and psychiatric features of the C9orf72 expansion. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/59693 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:49363/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Devenney, Emma. “Clinical characteristics and psychiatric features of the C9orf72 expansion.” 2016. Doctoral Dissertation, University of New South Wales. Accessed January 17, 2021. http://handle.unsw.edu.au/1959.4/59693 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:49363/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Devenney, Emma. “Clinical characteristics and psychiatric features of the C9orf72 expansion.” 2016. Web. 17 Jan 2021.

Vancouver:

Devenney E. Clinical characteristics and psychiatric features of the C9orf72 expansion. [Internet] [Doctoral dissertation]. University of New South Wales; 2016. [cited 2021 Jan 17]. Available from: http://handle.unsw.edu.au/1959.4/59693 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:49363/SOURCE02?view=true.

Council of Science Editors:

Devenney E. Clinical characteristics and psychiatric features of the C9orf72 expansion. [Doctoral Dissertation]. University of New South Wales; 2016. Available from: http://handle.unsw.edu.au/1959.4/59693 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:49363/SOURCE02?view=true

Vrije Universiteit Amsterdam

10. Engels, G. Moving along the non-motor spectrum of Parkinson's disease .

Degree: 2019, Vrije Universiteit Amsterdam

URL: http://hdl.handle.net/1871/56073

Subjects/Keywords: Parkinson's disease; non-motor symptoms; networks; resting-state fMRI

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Engels, G. (2019). Moving along the non-motor spectrum of Parkinson's disease . (Doctoral Dissertation). Vrije Universiteit Amsterdam. Retrieved from http://hdl.handle.net/1871/56073

Chicago Manual of Style (16^th Edition):

Engels, G. “Moving along the non-motor spectrum of Parkinson's disease .” 2019. Doctoral Dissertation, Vrije Universiteit Amsterdam. Accessed January 17, 2021. http://hdl.handle.net/1871/56073.

MLA Handbook (7^th Edition):

Engels, G. “Moving along the non-motor spectrum of Parkinson's disease .” 2019. Web. 17 Jan 2021.

Vancouver:

Engels G. Moving along the non-motor spectrum of Parkinson's disease . [Internet] [Doctoral dissertation]. Vrije Universiteit Amsterdam; 2019. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/1871/56073.

Council of Science Editors:

Engels G. Moving along the non-motor spectrum of Parkinson's disease . [Doctoral Dissertation]. Vrije Universiteit Amsterdam; 2019. Available from: http://hdl.handle.net/1871/56073

University of Debrecen

11. Adaba, Anthony Gambo. Current pharmacological treatments for motor symptoms of Parkinson's disease .

Degree: DE – Általános Orvostudományi Kar, University of Debrecen

URL: http://hdl.handle.net/2437/218548

► The treatment of Parkinson is vast. This body of work explores both the previous treatments and the current as well as the ones that are… (more)

Subjects/Keywords: Parkinson; Motor symptoms; pharmacology; pharmacotherapy; current treatments

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Adaba, A. G. (n.d.). Current pharmacological treatments for motor symptoms of Parkinson's disease . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/218548

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Adaba, Anthony Gambo. “Current pharmacological treatments for motor symptoms of Parkinson's disease .” Thesis, University of Debrecen. Accessed January 17, 2021. http://hdl.handle.net/2437/218548.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Adaba, Anthony Gambo. “Current pharmacological treatments for motor symptoms of Parkinson's disease .” Web. 17 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Adaba AG. Current pharmacological treatments for motor symptoms of Parkinson's disease . [Internet] [Thesis]. University of Debrecen; [cited 2021 Jan 17]. Available from: http://hdl.handle.net/2437/218548.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Adaba AG. Current pharmacological treatments for motor symptoms of Parkinson's disease . [Thesis]. University of Debrecen; Available from: http://hdl.handle.net/2437/218548

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

12. Galet, Benjamin. Validating Gpr88 as a new therapeutic target in models of the neuropsychiatric symptoms of Parkinson's Disease : Validation de Gpr88 comme nouvelle cible thérapeutique dans des modèles des symptômes neuropsychiatriques de la Maladie de Parkinson.

Degree: Docteur es, Neurosciences, 2018, Sorbonne université

URL: http://www.theses.fr/2018SORUS524

►

Au-delà des symptômes moteurs, la maladie de Parkinson (MP) est également caractérisée par des symptômes psychiatriques tels que l’apathie, la dépression et des troubles cognitifs.… (more)

▼

Au-delà des symptômes moteurs, la maladie de Parkinson (MP) est également caractérisée par des symptômes psychiatriques tels que l’apathie, la dépression et des troubles cognitifs. Bien que les traitements courants puissent traiter ces symptômes, leur efficacité diminue au cours de la maladie et est limitée par le développement fréquent de complications graves telles que des dyskinésies et des troubles de l’impulsivité. Dans ce contexte, nous avons étudié le récepteur orphelin Gpr88 comme nouvelle cible thérapeutique. GPR88 est associé à des maladies neuropsychiatriques et est exprimé principalement dans le striatum, où il exerce une activité inhibitrice sur les afférences dopaminergiques qui dégénèrent au cours de la MP. Dans des modèles de symptômes moteurs ou psychiatriques de la MP chez le rat, nous avons donc inactivé l’expression de GPR88 dans différentes régions du striatum, et évalué les effets au niveau comportemental et moléculaire. Ces modèles nous ont permis de reproduire des altérations de l’activité striatale observées chez les patients, et de montrer que l’inactivation localisée de Gpr88 réduit les déficits moteurs, affectifs et cognitifs, notamment par la modulation du facteur de transcription ∆FosB. Ainsi, Gpr88 peut représenter une cible thérapeutique pertinente non seulement pour la MP, mais également pour d’autres maladies neuropsychiatriques.

Beyond the motor impairment, Parkinson’s disease (PD) is also characterised by an early appearance of psychiatric symptoms such as apathy, depression and cognitive deficits. While current treatments may provide some level of symptomatic relief, their efficacy decreases with time and is limited by the frequent development of adverse effects such as dyskinesia and impulse-control disorders. In this context, we evaluated the orphan receptor Gpr88 as a new therapeutic target. GPR88 is associated with neuropsychiatric disorders, and is highly expressed in the striatum where it exerts inhibitory control over the dopaminergic inputs that degenerate in PD. In rat models of the motor or psychiatric symptoms of PD, we thus knocked-down (KD) the expression of the Gpr88 in different striatal regions, and assessed the effects at behavioural and molecular levels. These models allowed us to reproduce alterations in striatal activity that have been observed in patients, and to demonstrate that localised Gpr88-KD reverses the deficits in motor activity, mood, motivation and cognition, notably through modulation of transcription factor ∆FosB. This work thus supports the relevance of Gpr88 as a therapeutic target for the treatment of PD, as well as for other neuropsychiatric disorders.

Advisors/Committee Members: Meloni, Rolando (thesis director).

Subjects/Keywords: Maladie de Parkinson; Symptômes non-moteurs; Modèles animaux; Gpr88; Vecteurs lentiviraux; Psychiatrie; Parkinson's disease; Non-motor symptoms; Gpr88; 573.84

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Galet, B. (2018). Validating Gpr88 as a new therapeutic target in models of the neuropsychiatric symptoms of Parkinson's Disease : Validation de Gpr88 comme nouvelle cible thérapeutique dans des modèles des symptômes neuropsychiatriques de la Maladie de Parkinson. (Doctoral Dissertation). Sorbonne université. Retrieved from http://www.theses.fr/2018SORUS524

Chicago Manual of Style (16^th Edition):

Galet, Benjamin. “Validating Gpr88 as a new therapeutic target in models of the neuropsychiatric symptoms of Parkinson's Disease : Validation de Gpr88 comme nouvelle cible thérapeutique dans des modèles des symptômes neuropsychiatriques de la Maladie de Parkinson.” 2018. Doctoral Dissertation, Sorbonne université. Accessed January 17, 2021. http://www.theses.fr/2018SORUS524.

MLA Handbook (7^th Edition):

Galet, Benjamin. “Validating Gpr88 as a new therapeutic target in models of the neuropsychiatric symptoms of Parkinson's Disease : Validation de Gpr88 comme nouvelle cible thérapeutique dans des modèles des symptômes neuropsychiatriques de la Maladie de Parkinson.” 2018. Web. 17 Jan 2021.

Vancouver:

Galet B. Validating Gpr88 as a new therapeutic target in models of the neuropsychiatric symptoms of Parkinson's Disease : Validation de Gpr88 comme nouvelle cible thérapeutique dans des modèles des symptômes neuropsychiatriques de la Maladie de Parkinson. [Internet] [Doctoral dissertation]. Sorbonne université; 2018. [cited 2021 Jan 17]. Available from: http://www.theses.fr/2018SORUS524.

Council of Science Editors:

Galet B. Validating Gpr88 as a new therapeutic target in models of the neuropsychiatric symptoms of Parkinson's Disease : Validation de Gpr88 comme nouvelle cible thérapeutique dans des modèles des symptômes neuropsychiatriques de la Maladie de Parkinson. [Doctoral Dissertation]. Sorbonne université; 2018. Available from: http://www.theses.fr/2018SORUS524

13. Engels, G. Moving along the non-motor spectrum of Parkinson's disease.

Degree: 2019, NARCIS

URL: https://research.vu.nl/en/publications/f7021c03-5fd7-4810-b403-bfb28be79399 ; urn:nbn:nl:ui:31-1871/56073 ; f7021c03-5fd7-4810-b403-bfb28be79399 ; 1871/56073 ; urn:isbn:9789402815030 ; urn:nbn:nl:ui:31-1871/56073 ; https://research.vu.nl/en/publications/f7021c03-5fd7-4810-b403-bfb28be79399

Subjects/Keywords: Parkinson's disease; non-motor symptoms; networks; resting-state fMRI

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Engels, G. (2019). Moving along the non-motor spectrum of Parkinson's disease. (Doctoral Dissertation). NARCIS. Retrieved from https://research.vu.nl/en/publications/f7021c03-5fd7-4810-b403-bfb28be79399 ; urn:nbn:nl:ui:31-1871/56073 ; f7021c03-5fd7-4810-b403-bfb28be79399 ; 1871/56073 ; urn:isbn:9789402815030 ; urn:nbn:nl:ui:31-1871/56073 ; https://research.vu.nl/en/publications/f7021c03-5fd7-4810-b403-bfb28be79399

Chicago Manual of Style (16^th Edition):

Engels, G. “Moving along the non-motor spectrum of Parkinson's disease.” 2019. Doctoral Dissertation, NARCIS. Accessed January 17, 2021. https://research.vu.nl/en/publications/f7021c03-5fd7-4810-b403-bfb28be79399 ; urn:nbn:nl:ui:31-1871/56073 ; f7021c03-5fd7-4810-b403-bfb28be79399 ; 1871/56073 ; urn:isbn:9789402815030 ; urn:nbn:nl:ui:31-1871/56073 ; https://research.vu.nl/en/publications/f7021c03-5fd7-4810-b403-bfb28be79399.

MLA Handbook (7^th Edition):

Engels, G. “Moving along the non-motor spectrum of Parkinson's disease.” 2019. Web. 17 Jan 2021.

Vancouver:

Engels G. Moving along the non-motor spectrum of Parkinson's disease. [Internet] [Doctoral dissertation]. NARCIS; 2019. [cited 2021 Jan 17]. Available from: https://research.vu.nl/en/publications/f7021c03-5fd7-4810-b403-bfb28be79399 ; urn:nbn:nl:ui:31-1871/56073 ; f7021c03-5fd7-4810-b403-bfb28be79399 ; 1871/56073 ; urn:isbn:9789402815030 ; urn:nbn:nl:ui:31-1871/56073 ; https://research.vu.nl/en/publications/f7021c03-5fd7-4810-b403-bfb28be79399.

Council of Science Editors:

Engels G. Moving along the non-motor spectrum of Parkinson's disease. [Doctoral Dissertation]. NARCIS; 2019. Available from: https://research.vu.nl/en/publications/f7021c03-5fd7-4810-b403-bfb28be79399 ; urn:nbn:nl:ui:31-1871/56073 ; f7021c03-5fd7-4810-b403-bfb28be79399 ; 1871/56073 ; urn:isbn:9789402815030 ; urn:nbn:nl:ui:31-1871/56073 ; https://research.vu.nl/en/publications/f7021c03-5fd7-4810-b403-bfb28be79399

14. Gustavsson, Emelie. Livskvalité vid Parkinsons sjukdom : En allmän litteraturstudie.

Degree: The Swedish Red Cross University College, 2017, The Swedish Red Cross University College

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:rkh:diva-2530

►

Bakgrund: Parkinsons sjukdom är en kronisk progredierande neurodegenerativ sjukdom och är den näst största i dess slag. Sjukdomen kan ge uttryck i både motoriska… (more)

▼

Bakgrund: Parkinsons sjukdom är en kronisk progredierande neurodegenerativ sjukdom och är den näst största i dess slag. Sjukdomen kan ge uttryck i både motoriska och icke-motoriska symtom. Genom sjukdomsförloppet genomgår personen olika faser som medför förlust av både mentala och kroppsliga funktioner. Förlusten av funktionerna ger en generellt sämre livskvalitet än hos andra personer. Syfte: Syftet med litteraturöversikten var att belysa symtomens påverkan på livskvaliteten hos personer med Parkinsons sjukdom. Metod: En allmän litteraturstudie baserad på tio kvalitativa studier. Resultat: Resultatet visar på att personer som lever med Parkinsons sjukdom har en komplex livssituation. De fysiska symtom som sjukdomen kännetecknas av ger svårigheter i vardagen. Resultatet visar också att den psykiska hälsan blir väsentligt påverkad i samband med detta. En följd av de fysiska och psykiska symtomen kan leda till social isolering, och tillsammans kan dessa skapa en kedjereaktion som leder till en försämrad livskvalitet. Slutsats och förslag på forskning: De motoriska symtomen är det mest påfrestande med att leva med Parkinsons sjukdom och bidrar starkt till en minskad livskvalitet. Därför behövs vidare omvårdnadsforskning för personer med Parkinsons sjukdom samt vilka omvårdnadsåtgärder som skulle kunna leda till förbättrad livskvalitet.

Background: Parkinson's disease is a chronic progressive neurodegenerative disease and is the second largest of its kind. The disease expresses both motor and non-motor symptoms. Through the course of the disease, the person undergoes different phases that cause loss of both mental and physical functions. The loss of functions gives a generally poorer quality of life than other people. Aim: The aim of the literature review was to highlight the effects of the symptoms on quality of life for people with Parkinson's disease. Method: A general literature study based on ten qualitative studies. Result: The result shows that people who are living with Parkinson's disease, lives in a complex life situation. The physical symptoms that the disease is characterized by creates difficulties in everyday life. The result also shows that mental health is significantly affected in this regard. A consequence of the physical and mental symptoms can lead to social isolation, and together they can create a chain reaction that leads to a deteriorating quality of life. Conclusion and Suggestions for Research: The motor symptoms are the most profound of living with Parkinson's disease and contribute significantly to a reduced quality of life. Therefore, nursing research is needed for people with Parkinson's disease as well as nursing measures that could lead to improved quality of life.

Subjects/Keywords: Parkinson’s disease; Quality of life; Motor and non-motor symptoms; Patient perspective; Daily life.; Parkinsons sjukdom; Livskvalitet; Motoriska och icke motoriska symtom; Patientperspektiv; Dagligt liv.; Nursing; Omvårdnad

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gustavsson, E. (2017). Livskvalité vid Parkinsons sjukdom : En allmän litteraturstudie. (Thesis). The Swedish Red Cross University College. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:rkh:diva-2530

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gustavsson, Emelie. “Livskvalité vid Parkinsons sjukdom : En allmän litteraturstudie.” 2017. Thesis, The Swedish Red Cross University College. Accessed January 17, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:rkh:diva-2530.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gustavsson, Emelie. “Livskvalité vid Parkinsons sjukdom : En allmän litteraturstudie.” 2017. Web. 17 Jan 2021.

Vancouver:

Gustavsson E. Livskvalité vid Parkinsons sjukdom : En allmän litteraturstudie. [Internet] [Thesis]. The Swedish Red Cross University College; 2017. [cited 2021 Jan 17]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:rkh:diva-2530.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gustavsson E. Livskvalité vid Parkinsons sjukdom : En allmän litteraturstudie. [Thesis]. The Swedish Red Cross University College; 2017. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:rkh:diva-2530

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

15. Millot, Mathilde. Implication de la sérotonine dans l'expression de troubles moteurs et neuropsycho-comportementaux dans la maladie de Parkison : Impact of a serotonergic lesion on the expression of motor and neuropsychiatric symptoms.

Degree: Docteur es, Neurosciences, 2019, Lyon

URL: http://www.theses.fr/2019LYSE1100

►

La maladie de Parkinson (MP) se caractérise par une dégénérescence progressive et irréversible des neurones dopaminergiques de la substance noire induisant une perte de dopamine… (more)

▼

La maladie de Parkinson (MP) se caractérise par une dégénérescence progressive et irréversible des neurones dopaminergiques de la substance noire induisant une perte de dopamine (DA) dans les structures cibles. Lorsque cette perte DA se situe entre 60 % et 80 %, les patients présentent des symptômes moteurs (rigidité, tremblement, akinésie) et non-moteurs très variés (dépression, anxiété, apathie). Ces derniers apparaissent avant et/ou en même temps que les symptômes moteurs. La dopathérapie permet de contrecarrer certains symptômes, mais tous ne sont pas sensibles à cette médication. Parallèlement à la dégénérescence DA, le système sérotoninergique (5-HT) serait aussi altéré de façon précoce dans la maladie. Cette dégénérescence est liée par l’expression de symptômes moteurs et non-moteurs. Néanmoins, aucun lien causal n’a été mis en évidence entre cette lésion 5-HT et la symptomatologie parkinsonienne. Ainsi, il était primordial de déterminer le rôle de la 5-HT dans 1) l’expression des troubles moteurs et non-moteurs 2) dans la réponse au traitement sérotoninergique et dopaminergique. Nous avons utilisé un nouveau modèle animal primate ayant une lésion 5-HT (via la MDMA) puis une lésion DA (via le MPTP). Ce modèle nous permet de mettre en évidence l’impact d’une lésion 5-HT précoce dans la symptomatologie. Des approches comportementales, pharmacologiques, d’imagerie et de neuroanatomie ont été utilisées. La lésion 5-HT a induit un trouble anxieux chez les animaux lésés à la MDMA, qui ne sont pas contrecarrer avec un traitement sérotoninergique (antidépresseur). Cette lésion a également induit une sévérité et une progression plus rapide des symptômes moteurs induits par la lésion DA

Parkinson’s disease (PD) is characterized by a progressive and irreversible degeneration of dopaminergic (DA) neurons localized in the substantia nigra, leading to a loss of dopamine within the target structures. When the loss of DA reaches 60 to 80 %, PD patients develop a wide range of motor (rigidity, tremor, akinesia fro example) and non-motor (depression, anxiety, apathy for example) symptoms. Dopatherapy allows the reduction of symptoms expression. But some motor and non-motor symptoms are not counteracted by those DA drugs. In addition to DA degeneration, patients present an early serotonergic (5-HT) lesion. This lesion is linked to the severity of some motor and non-motor symptoms. However, there is no causal link established between 5-HT lesion and parkinsonian symptoms. Therefore, it was essential to determine the role of 5-HT 1) in the expression of motor and non-motor symptoms 2) and in the response of DA and 5-HT treatments. For that, we used a new monkey model of PD, exhibiting a 5-HT lesion (with MDMA ‘”ecstasy”)) followed by a DA lesion (with MPTP). This model allowed us to evaluate the impact of an early 5-HT lesion on parkinsonian symptoms. We used different approaches: PET imaging, pharmacology, behavioral and neuroanatomy. The MDMA-driven early 5-HT lesion induced an anxious-like behavior on MDMA treatedmonkeys.…

Advisors/Committee Members: Sgambato-Faure, Véronique (thesis director).

Subjects/Keywords: Maladie de Parkinson; Dopamine; Sérotonine; MPTP; MDMA; Fluoxétine; Pramipexole; Symptômes moteurs et non-moteurs; Parkinson’s disease; Dopamine; Serotonin; MPTP; MDMA; Fluoxetine; Pramipexole; Motor and non-motor symptoms; 570

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Millot, M. (2019). Implication de la sérotonine dans l'expression de troubles moteurs et neuropsycho-comportementaux dans la maladie de Parkison : Impact of a serotonergic lesion on the expression of motor and neuropsychiatric symptoms. (Doctoral Dissertation). Lyon. Retrieved from http://www.theses.fr/2019LYSE1100

Chicago Manual of Style (16^th Edition):

Millot, Mathilde. “Implication de la sérotonine dans l'expression de troubles moteurs et neuropsycho-comportementaux dans la maladie de Parkison : Impact of a serotonergic lesion on the expression of motor and neuropsychiatric symptoms.” 2019. Doctoral Dissertation, Lyon. Accessed January 17, 2021. http://www.theses.fr/2019LYSE1100.

MLA Handbook (7^th Edition):

Millot, Mathilde. “Implication de la sérotonine dans l'expression de troubles moteurs et neuropsycho-comportementaux dans la maladie de Parkison : Impact of a serotonergic lesion on the expression of motor and neuropsychiatric symptoms.” 2019. Web. 17 Jan 2021.

Vancouver:

Millot M. Implication de la sérotonine dans l'expression de troubles moteurs et neuropsycho-comportementaux dans la maladie de Parkison : Impact of a serotonergic lesion on the expression of motor and neuropsychiatric symptoms. [Internet] [Doctoral dissertation]. Lyon; 2019. [cited 2021 Jan 17]. Available from: http://www.theses.fr/2019LYSE1100.

Council of Science Editors:

Millot M. Implication de la sérotonine dans l'expression de troubles moteurs et neuropsycho-comportementaux dans la maladie de Parkison : Impact of a serotonergic lesion on the expression of motor and neuropsychiatric symptoms. [Doctoral Dissertation]. Lyon; 2019. Available from: http://www.theses.fr/2019LYSE1100

Brno University of Technology

16. Galáž, Zoltán. Hodnocení Parkinsonovy nemoci na základě akustické analýzy hypokinetické dysartrie: Assessment of Parkinson’s Disease Based on Acoustic Analysis of Hypokinetic Dysarthria.

Degree: 2018, Brno University of Technology

URL: http://hdl.handle.net/11012/137115

► Hypokinetic dysarthria (HD) is a speech disorder occurring in up to 90% of patients suffering from idiopathic Parkinson’s disease (PD) that significantly contributes to unnaturalness… (more)

Subjects/Keywords: Parkinsonova nemoc; hypokinetická dysartrie; akustická analýza; diagnóza; kvantitativní analýza; motorické příznaky; nemotorické příznaky; objektivní hodnocení; statistické zpracování; strojové učení; zárazy v chůzi.; Parkinson’s disease; hypokinetic dysarthria; acoustic analysis; diagnosis; freezing of gait; machine learning; motor symptoms; non-motor symptoms; objective assessment; quantitative analysis; statistical processing.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Galáž, Z. (2018). Hodnocení Parkinsonovy nemoci na základě akustické analýzy hypokinetické dysartrie: Assessment of Parkinson’s Disease Based on Acoustic Analysis of Hypokinetic Dysarthria. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/137115

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Galáž, Zoltán. “Hodnocení Parkinsonovy nemoci na základě akustické analýzy hypokinetické dysartrie: Assessment of Parkinson’s Disease Based on Acoustic Analysis of Hypokinetic Dysarthria.” 2018. Thesis, Brno University of Technology. Accessed January 17, 2021. http://hdl.handle.net/11012/137115.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Galáž, Zoltán. “Hodnocení Parkinsonovy nemoci na základě akustické analýzy hypokinetické dysartrie: Assessment of Parkinson’s Disease Based on Acoustic Analysis of Hypokinetic Dysarthria.” 2018. Web. 17 Jan 2021.

Vancouver:

Galáž Z. Hodnocení Parkinsonovy nemoci na základě akustické analýzy hypokinetické dysartrie: Assessment of Parkinson’s Disease Based on Acoustic Analysis of Hypokinetic Dysarthria. [Internet] [Thesis]. Brno University of Technology; 2018. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/11012/137115.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Galáž Z. Hodnocení Parkinsonovy nemoci na základě akustické analýzy hypokinetické dysartrie: Assessment of Parkinson’s Disease Based on Acoustic Analysis of Hypokinetic Dysarthria. [Thesis]. Brno University of Technology; 2018. Available from: http://hdl.handle.net/11012/137115

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Univerzitet u Beogradu

17. Kresojević, Nikola D., 1981-. Učestalost i specifičnost ispoljavanja Parkinsonove bolesti kod homozigotnih i heterozigotnih nosilaca mutacije gena za glukocerebrozidazu.

Degree: Medicinski fakultet, 2016, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:12486/bdef:Content/get

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Medicina / Medicine

Uvod: Nedavno je otkriveno da nosioci mutacija u genu za glukocerebrozidazu (GBA), kako u homozigotnom stanju, kod pacijenata koji imaju Gošeovu bolest… (more)

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Medicina / Medicine

Uvod: Nedavno je otkriveno da nosioci mutacija u genu za glukocerebrozidazu (GBA), kako u homozigotnom stanju, kod pacijenata koji imaju Gošeovu bolest (GB), tako i kod heterozigotnih nosilaca ove mutacije, imaju veću šansu da obole od Parkinsonove bolesti (PB). Prema literaturnim podacima, klinička slika Parkinsonove bolesti kod nosilaca mutacije u GBA genu, slična je fenotipu sporadične forme. Ciljevi: Utvrđivanje učestalosti GBA mutacija u grupi pacijenata sa PB u Srbiji i karakterizacija genotipa. Određivanje specifičnosti kliničkog ispoljavanja PB kod heterozigotnih i homozigotnih nosilaca GBA mutacija i utvrđivanje genotipsko-fenotipske korelacije. Utvrđivanje neuroimidžing karakteristika PB pacijenata sa GBA mutacijama, zdravih nosilaca GBA mutacija i pacijenata sa GB. Materijal i metode: Analiza egzona 8-11 GBA gena obavljena je kod 644 PB pacijenta i 368 zdravih kontrola. Pored toga, pregledano je 18 pacijenata sa GB i njihovih 14 srodnika prvog stepena koji su obavezni nosioci GBA mutacija. Nakon određivanja GBA statusa i prisustva PB kod ovih ispitanika, formirane su grupe za dalju analizu. Dizajn po tipu studije preseka korišćen je za računanje odnosa šansi prisustva GBA mutacije u ispitivanim grupama, kao i za utvrđivanje osnovnih kliničkih karakeristika PB kod nosilaca GBA mutacija. Dizajn po tipu studije slučajeva i kontrola korišćen je za utvrđivanje nemotornih karakteristika kao i imidžing razlika kod PB udružene sa GBA mutacijama u poređenju sa sporadičnom PB (bez mutacija u GBA genu, sPB). Ekstenzivna testiranja za procenu kognitivnih, bihejvioralnih, motornih i nemotornih karakteristika uključile su: Unified Parkinson Disease Rating Scale (UPDRS), Hoehn i Yahr stadijum PB, Mini Mental State Examination (MMSE), Hamiltonovu skalu depresivnosti, Hamiltonovu skalu anksioznosti, Bekovu skalu za depresiju, skalu apatije, upitnik nemotornih simptoma, Adenbruksovo kognitivno ispitivanje i Bostonski test nominacije. Pregled mozga je obavljen na aparatu za magnetnu rezonanciju (MR) jačine 1,5 T. Na snimcima je određivano ukupno opterećenje hiperintenznim lezijama bele mase, zapremina sive mase mozga pomoću morfometrije zasnovane na vokselu i analiza puteva bele mase metodom difuzionog tenzorskog imidžinga. Transkranijalna sonografija mozga (TKS) korišćena je za analizu struktura srednje linije moždanog stabla. Kod zdravih nosilaca GBA mutacije, bez jasnih znakova PB, urađen je DaT-SPECT u cilju utvrđivanja premotorne faze PB...

Advisors/Committee Members: Kostić, Vladimir, 1953-.

Subjects/Keywords: Parkinson’s disease (PD); glucocerebrosidase (GC-ase); Gaucher's disease (GD); behavior; cognitive impairment; non-motor symptoms; magnetic resonance imaging (MRI); voxel-based morphometry (VBM); diffusion tensor imaging (DTI); transcranial sonography (TCS)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kresojević, Nikola D., 1. (2016). Učestalost i specifičnost ispoljavanja Parkinsonove bolesti kod homozigotnih i heterozigotnih nosilaca mutacije gena za glukocerebrozidazu. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:12486/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kresojević, Nikola D., 1981-. “Učestalost i specifičnost ispoljavanja Parkinsonove bolesti kod homozigotnih i heterozigotnih nosilaca mutacije gena za glukocerebrozidazu.” 2016. Thesis, Univerzitet u Beogradu. Accessed January 17, 2021. https://fedorabg.bg.ac.rs/fedora/get/o:12486/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kresojević, Nikola D., 1981-. “Učestalost i specifičnost ispoljavanja Parkinsonove bolesti kod homozigotnih i heterozigotnih nosilaca mutacije gena za glukocerebrozidazu.” 2016. Web. 17 Jan 2021.

Vancouver:

Kresojević, Nikola D. 1. Učestalost i specifičnost ispoljavanja Parkinsonove bolesti kod homozigotnih i heterozigotnih nosilaca mutacije gena za glukocerebrozidazu. [Internet] [Thesis]. Univerzitet u Beogradu; 2016. [cited 2021 Jan 17]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:12486/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kresojević, Nikola D. 1. Učestalost i specifičnost ispoljavanja Parkinsonove bolesti kod homozigotnih i heterozigotnih nosilaca mutacije gena za glukocerebrozidazu. [Thesis]. Univerzitet u Beogradu; 2016. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:12486/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

18. Bennouar, Khaled-Ezaheir. Le récepteur métabotropique du glutamate de type 4 comme cible thérapeutique pour la maladie de Parkinson : Targeting metabotropic glutamate receptor 4 for the treatment of Parkinson' s disease.

Degree: Docteur es, Neurosciences, 2012, Aix Marseille Université

URL: http://www.theses.fr/2012AIXM4022

►

La maladie de Parkinson (MP) est une maladie neurodégénérative chronique qui apparait en moyenne à partir 55 ans. Sa cause reste inconnue mais son apparition… (more)

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La maladie de Parkinson (MP) est une maladie neurodégénérative chronique qui apparait en moyenne à partir 55 ans. Sa cause reste inconnue mais son apparition et son développement sont corrélés avec la perte progressive des neurones dopaminergique de la substance noire qui innervent les ganglions de la base (GB). Jusqu'à ce jour le traitement le plus efficace est basé sur la compensation du déficit en dopamine (DA) par l'administration de son précurseur, la L-DOPA, qui est métabolisé en DA. Ce traitement améliore les symptômes moteurs de la maladie et donc la qualité de vie des patients. Néanmoins, après une certaine période des effets secondaires invalidants apparaissent, en particulier des fluctuations motrices et des mouvements anormaux involontaires appelés dyskinésies. De plus, ce traitement n'apporte pas de réponse à la progression de la dégénérescence et donc de la maladie. C'est pour ces raisons que la communauté scientifique est à la recherche d'une thérapie pharmacologique alternative à la L-DOPA, ou du moins visant à minimiser ses effets indésirables. Dans ce contexte, les récepteurs métabotropiques du glutamate, en particulier mGluR4, semblent constituer une cible privilégiée. En effet, mGluR4 est situé à des synapses des GB supposées hyperactives dans la MP, et son activation par des moyens pharmacologiques pourrait donc rétablir une activité normale grâce à son action inhibitrice sur la libération de neurotransmetteur. Nos résultats démontrent le bien-fondé de cette hypothèse sur le plan fonctionnel, en utilisant un nouvel agoniste allostérique spécifique de mGluR4, Lu AF21934.

Parkinson's disease (PD) is a progressive neurodegenerative disorder that appears around 55 years of age. The causes of PD remain unknown but its appearance and progression are correlated with the progressive loss of dopaminergic neurons of substantia nigra pars compacta innervating the basal ganglia (BG). Up to date, the most efficient treatment is based on restoring a normal level of dopamine (DA) in the brain by the administration of L-DOPA, a DA precursor that is metabolized to DA. However, at long term, L-DOPA treatment induces some side-effects, in particular the highly disabling L-DOPA-induced dyskinesia (LID). For this reason, the scientific community is searching for a pharmacological treatment alternative to L-DOPA and/or minimizing LID. In this context, metabotropic glutamate receptors, in particular mGluR4, are targets of interest. mGlu4 are localized at presynaptic terminals within BG circuitry that become hyperactive in PD. For this reason, mGluR4 has been considered a key strategic target for non-dopaminergic pharmacological treatments aimed at modulating these synapses, due to its ability to reduce neurotransmitter release. Herein we provide physiological and functional support to this hypothesis using Lu AF21934, a novel selective and brain-penetrant mGluR4 positive allosteric modulator (PAM). By in vitro electrophysiological recordings we demonstrate that Lu AF21934 inhibits corticostriatal synaptic…

Advisors/Committee Members: Gubellini, Paolo (thesis director).

Subjects/Keywords: Maladie de Parkinson; Symptômes moteurs; Akinesie; Dyskinesie; Récepteurs métabotropiques du glutamate; Modulateurs allostériques; Parkinson's disease; Motor symptoms; Akinesia; Dyskinesia; Metabotropic glutamate receptors; Allosteric modulators

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bennouar, K. (2012). Le récepteur métabotropique du glutamate de type 4 comme cible thérapeutique pour la maladie de Parkinson : Targeting metabotropic glutamate receptor 4 for the treatment of Parkinson' s disease. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2012AIXM4022

Chicago Manual of Style (16^th Edition):

Bennouar, Khaled-Ezaheir. “Le récepteur métabotropique du glutamate de type 4 comme cible thérapeutique pour la maladie de Parkinson : Targeting metabotropic glutamate receptor 4 for the treatment of Parkinson' s disease.” 2012. Doctoral Dissertation, Aix Marseille Université. Accessed January 17, 2021. http://www.theses.fr/2012AIXM4022.

MLA Handbook (7^th Edition):

Bennouar, Khaled-Ezaheir. “Le récepteur métabotropique du glutamate de type 4 comme cible thérapeutique pour la maladie de Parkinson : Targeting metabotropic glutamate receptor 4 for the treatment of Parkinson' s disease.” 2012. Web. 17 Jan 2021.

Vancouver:

Bennouar K. Le récepteur métabotropique du glutamate de type 4 comme cible thérapeutique pour la maladie de Parkinson : Targeting metabotropic glutamate receptor 4 for the treatment of Parkinson' s disease. [Internet] [Doctoral dissertation]. Aix Marseille Université 2012. [cited 2021 Jan 17]. Available from: http://www.theses.fr/2012AIXM4022.

Council of Science Editors:

Bennouar K. Le récepteur métabotropique du glutamate de type 4 comme cible thérapeutique pour la maladie de Parkinson : Targeting metabotropic glutamate receptor 4 for the treatment of Parkinson' s disease. [Doctoral Dissertation]. Aix Marseille Université 2012. Available from: http://www.theses.fr/2012AIXM4022

19. Hesselgren, Katarina. Översättning och validering av del III, Motor Examination, i bedömningsinstrumentet MDS-UPDRS för utvärdering av motoriska symtom vid Parkinsons sjukdom.

Degree: Medical Science, 2019, Dalarna University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:du-30782

►

Bakgrund: Unified Parkinson’s Disease Rating Scale är ett bedömningsinstrument som är frekvent använt, både i Sverige och internationellt, inom vården för personer med Parkinsons… (more)

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Bakgrund: Unified Parkinson’s Disease Rating Scale är ett bedömningsinstrument som är frekvent använt, både i Sverige och internationellt, inom vården för personer med Parkinsons sjukdom. Under 2001 granskades och reviderades instrumentet vilket resulterade i en ny version benämnt Movement Disorder Society Unified Disease Rating Scale. Del III av MDSUPDRS syftar till att undersöka motoriska symtom och anses viktiga i bland annat fysioterapeuters utredning och som utvärdering efter behandling. I dagsläget saknas en svensk validerad översättning av del III. Syfte: Syftet med detta arbete var att översätta del III av bedömningsinstrumentet MDSUPDRS från engelska till svenska och därefter undersöka innehållsvaliditet för den svenska versionen. Metod: Översättningen skedde genom forward translation, backward translation samt analys av innehållsvaliditet genom Content Validity Index (CVI). Översättningen undersöktes med hjälp av fem forskningspersoner, sakkunniga inom området. Validitet analyserades under två skattningsomgångar utifrån följande CVI-delar med tillhörande referensvärden: I-CVI (0,80), S-CVI/AVE (0,90) och S-CVI/UA (0,80). Resultat: Efter två omgångar skattade samtliga forskningspersoner 20 av 24 frågor som relevanta med ett I-CVI-värde på 1,0. Resterande fyra frågor uppnådde ett I-CVI-värde på 0,80. Värdena för S-CVI/AVE och S-CVI/UA var 0,97 respektive 0,83, vilket innebar att dessa översteg de uppsatta referensvärdena. Skalan kan därmed i sin helhet ses som valid, då samtliga CVI-värden uppnådde de uppsatta referensvärdena. Slutsats: Den översatta versionen kan i sin helhet betraktas som valid.

Background: The Unified Parkinson’s Disease Rating Scale is a frequently used assessment tool world wide in clinics in care of people with Parkinson’s disease. In 2001, the assessment tool were reviewed and revised, which was titled Movement Disorder Society Unified Parkinson’s Disease Rating Scale. Part III of MDS-UPDRS aims to investigate motor symptoms and is considered important in, among other things, physiotherapists' investigation, and as evaluation after treatment. Currently, a Swedish validated translation of Part III is lacking. Aim: The aim of this study is to translate part III of MDS-UPDRS from english to swedish, and then analyze content validity for the swedish version. Method: The translation was done with the use of forward translation, backward translation and the content validity was analyzed with Content Validity Index (CVI). The translation were analyzed in two rounds, with help by five individual proficient to the area. The content validity were set by following domains and reference values: I-CVI (0,80), S-CVI/AVE (0,90) and SCVI/UA (0,80). Results: After two rounds, 20 questions out of 24 reached an I-CVI of 1,0. The remaining four questions reached an I-CVI of 0,80. The values of S-CVI/AVE and S-CVI/UA were 0,97 and 0,83 which meant that it exceeded the set reference values. The integer scale can be considered valid based on the reference values on S-CVI/AVE and S-CVI/UA.…

Subjects/Keywords: Parkinson’s disease; translation; validation; assessment tool; MDS-UPDRS; motor symptoms.; Parkinsons sjukdom; översättning; validering; bedömningsinstrument; MDSUPDRS; motoriska symtom.; Other Medical Sciences; Annan medicin och hälsovetenskap

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hesselgren, K. (2019). Översättning och validering av del III, Motor Examination, i bedömningsinstrumentet MDS-UPDRS för utvärdering av motoriska symtom vid Parkinsons sjukdom. (Thesis). Dalarna University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:du-30782

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hesselgren, Katarina. “Översättning och validering av del III, Motor Examination, i bedömningsinstrumentet MDS-UPDRS för utvärdering av motoriska symtom vid Parkinsons sjukdom.” 2019. Thesis, Dalarna University. Accessed January 17, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:du-30782.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hesselgren, Katarina. “Översättning och validering av del III, Motor Examination, i bedömningsinstrumentet MDS-UPDRS för utvärdering av motoriska symtom vid Parkinsons sjukdom.” 2019. Web. 17 Jan 2021.

Vancouver:

Hesselgren K. Översättning och validering av del III, Motor Examination, i bedömningsinstrumentet MDS-UPDRS för utvärdering av motoriska symtom vid Parkinsons sjukdom. [Internet] [Thesis]. Dalarna University; 2019. [cited 2021 Jan 17]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:du-30782.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hesselgren K. Översättning och validering av del III, Motor Examination, i bedömningsinstrumentet MDS-UPDRS för utvärdering av motoriska symtom vid Parkinsons sjukdom. [Thesis]. Dalarna University; 2019. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:du-30782

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Western Ontario

20. Bernardinis, Matthew. Investigation of Visual Perceptions in Parkinson's Disease and the Development of Disease Monitoring Software.

Degree: 2019, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/6516

► Non-motor Parkinson’s Disease (PD) symptoms are substantial factors of PD arising throughout disease stages, yet their diagnosis and monitoring remain a challenge. Sensory abnormalities in… (more)

Subjects/Keywords: Parkinson's disease; Visual non-motor symptoms; Computer-generated graphical tool; velocity perception; displacement perception; temporal perception; Biomedical Devices and Instrumentation; Nervous System Diseases; Other Biomedical Engineering and Bioengineering

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bernardinis, M. (2019). Investigation of Visual Perceptions in Parkinson's Disease and the Development of Disease Monitoring Software. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/6516

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bernardinis, Matthew. “Investigation of Visual Perceptions in Parkinson's Disease and the Development of Disease Monitoring Software.” 2019. Thesis, University of Western Ontario. Accessed January 17, 2021. https://ir.lib.uwo.ca/etd/6516.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bernardinis, Matthew. “Investigation of Visual Perceptions in Parkinson's Disease and the Development of Disease Monitoring Software.” 2019. Web. 17 Jan 2021.

Vancouver:

Bernardinis M. Investigation of Visual Perceptions in Parkinson's Disease and the Development of Disease Monitoring Software. [Internet] [Thesis]. University of Western Ontario; 2019. [cited 2021 Jan 17]. Available from: https://ir.lib.uwo.ca/etd/6516.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bernardinis M. Investigation of Visual Perceptions in Parkinson's Disease and the Development of Disease Monitoring Software. [Thesis]. University of Western Ontario; 2019. Available from: https://ir.lib.uwo.ca/etd/6516

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Sydney

21. Bennett, Ethelle Jeanette. Functional Gastrointestinal Disorders: relations between psychosocial factors, symptoms and sensorimotor disturbances .

Degree: 1999, University of Sydney

URL: http://hdl.handle.net/2123/410

► Although a vast literature attests to the belief that psychosocial disturbance is an important component of functional gastrointestinal disorders (FGID), the relation of life stress,… (more)

▼ Although a vast literature attests to the belief that psychosocial disturbance is an important component of functional gastrointestinal disorders (FGID), the relation of life stress, psychological distress and personality to the development of these disorders is poorly understood. The broad objective of this thesis is to provide data on relations between psychosocial factors and FGID, especially irritable bowel syndrome (IBS) and functional dyspepsia (FD), in representative outpatient samples. Issues not previously addressed are examined in a series of studies. The first two studies are concerned with relations between psychosocial factors, extraintestinal (somatic) symptoms and the number and type of FGID syndromes present at consultation and, in IBS patients, the prospective relation of psychosocial factors to changes in symptom intensity over 16 months. The last three studies relate psychosocial factors to gastrointestinal (GI) transit, motor, and sensory function in FGID, abnormalities in these parameters representing the putative origin of symptoms in FGID. In total, 350 patients participated, representing a 95% participation rate. Important features of the methodology include the use of a recently standardised symptom-based classification system for FGID, an objective and reliable interview-based life stress instrument (The Life Events and Difficulties Schedule), and sophisticated and sensitive technologies to assess GI transit, motor and sensory function. Novel measures, which conceptually take into account the chronic, fluctuating and recurrent course of IBS and FD syndromes, and the tendency of these syndromes to coexist, are also included. Thus, measures of symptom outcome assess the number of syndromes present, while the symptom intensity variable reflects the severity and frequency of both FD and IBS symptoms, if both are present. Similarly, with respect to altered transit, and motor and sensory function, physiological outcome variables reflect not only the presence of an abnormality but the number of regions affected, and the type and number of abnormalities present. Cross-sectional findings showed for the first time that psychosocial disturbance is associated with FGID symptomatology in a quantitative manner, that chronic life stress threat is central to this process and this stress-related process is a prominent feature of a particular group of syndromes (ie IBS/FD) defined primarily by the presence of pain and discomfort. A combination of psychological, social and biological factors combined to predict the number of FGID syndromes present at entry into the study. Prominent among them was an angry, reactive and anxious (neurotic) personality, chronic life stress threat, increased coping, poor emotional support and increased age. In addition to a greater number of FD/IBS syndromes, individuals with an anger-reactive response style had experienced more intense pain and discomfort, and displayed more complete sensorimotor disturbance. Longitudinal data demonstrated (also for the first time) the…

Subjects/Keywords: functional gastrointestinal disorders; life stress; psychological; symptoms; sensory and motor disturbances

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bennett, E. J. (1999). Functional Gastrointestinal Disorders: relations between psychosocial factors, symptoms and sensorimotor disturbances . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/410

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bennett, Ethelle Jeanette. “Functional Gastrointestinal Disorders: relations between psychosocial factors, symptoms and sensorimotor disturbances .” 1999. Thesis, University of Sydney. Accessed January 17, 2021. http://hdl.handle.net/2123/410.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bennett, Ethelle Jeanette. “Functional Gastrointestinal Disorders: relations between psychosocial factors, symptoms and sensorimotor disturbances .” 1999. Web. 17 Jan 2021.

Vancouver:

Bennett EJ. Functional Gastrointestinal Disorders: relations between psychosocial factors, symptoms and sensorimotor disturbances . [Internet] [Thesis]. University of Sydney; 1999. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/2123/410.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bennett EJ. Functional Gastrointestinal Disorders: relations between psychosocial factors, symptoms and sensorimotor disturbances . [Thesis]. University of Sydney; 1999. Available from: http://hdl.handle.net/2123/410

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Western Ontario

22. Iftikar Mohideen, Shabna. The use of current steering during subthalamic deep brain stimulation to alleviate upper limb symptoms of Parkinson's disease.

Degree: 2018, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/5882

► Subthalamic (STN) deep brain stimulation (DBS) is an established treatment to alleviate the appendicular motor symptoms of Parkinson's Disease (PD). Current steering during DBS allows… (more)

Subjects/Keywords: Parkinson’s disease; deep brain stimulation; current steering; motor symptoms; appendicular symptoms; upper limb; electrical field; current fractionation; Analytical, Diagnostic and Therapeutic Techniques and Equipment; Nervous System; Nervous System Diseases; Neuroscience and Neurobiology; Pharmacology; Physiology

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APA (6^th Edition):

Iftikar Mohideen, S. (2018). The use of current steering during subthalamic deep brain stimulation to alleviate upper limb symptoms of Parkinson's disease. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/5882

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Iftikar Mohideen, Shabna. “The use of current steering during subthalamic deep brain stimulation to alleviate upper limb symptoms of Parkinson's disease.” 2018. Thesis, University of Western Ontario. Accessed January 17, 2021. https://ir.lib.uwo.ca/etd/5882.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Iftikar Mohideen, Shabna. “The use of current steering during subthalamic deep brain stimulation to alleviate upper limb symptoms of Parkinson's disease.” 2018. Web. 17 Jan 2021.

Vancouver:

Iftikar Mohideen S. The use of current steering during subthalamic deep brain stimulation to alleviate upper limb symptoms of Parkinson's disease. [Internet] [Thesis]. University of Western Ontario; 2018. [cited 2021 Jan 17]. Available from: https://ir.lib.uwo.ca/etd/5882.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Iftikar Mohideen S. The use of current steering during subthalamic deep brain stimulation to alleviate upper limb symptoms of Parkinson's disease. [Thesis]. University of Western Ontario; 2018. Available from: https://ir.lib.uwo.ca/etd/5882

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Leiden University

23. Zhu, K. Clinical Predictors of disease progression in Parkinson's disease.

Degree: 2017, Leiden University

URL: http://hdl.handle.net/1887/55513

► In this thesis, longitudinal analyses have been performed on the PROPARK-Cohort, a hospital-based cohort of 421 patients followed for a period of five years. The… (more)

Subjects/Keywords: Parkinson's disease; Non-motor symptoms; Predictors; Dementia; Psychosis; Depression; Sleeping disorders; Parkinson's disease; Non-motor symptoms; Predictors; Dementia; Psychosis; Depression; Sleeping disorders

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APA (6^th Edition):

Zhu, K. (2017). Clinical Predictors of disease progression in Parkinson's disease. (Doctoral Dissertation). Leiden University. Retrieved from http://hdl.handle.net/1887/55513

Chicago Manual of Style (16^th Edition):

Zhu, K. “Clinical Predictors of disease progression in Parkinson's disease.” 2017. Doctoral Dissertation, Leiden University. Accessed January 17, 2021. http://hdl.handle.net/1887/55513.

MLA Handbook (7^th Edition):

Zhu, K. “Clinical Predictors of disease progression in Parkinson's disease.” 2017. Web. 17 Jan 2021.

Vancouver:

Zhu K. Clinical Predictors of disease progression in Parkinson's disease. [Internet] [Doctoral dissertation]. Leiden University; 2017. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/1887/55513.

Council of Science Editors:

Zhu K. Clinical Predictors of disease progression in Parkinson's disease. [Doctoral Dissertation]. Leiden University; 2017. Available from: http://hdl.handle.net/1887/55513

24. Evans, Matthew C. Quantitative Analysis of Novel Chemical and shRNA Based Methods to Increase Survival of Motor Neuron Protein Levels.

Degree: Interdisciplinary Graduate Program, Medicine, 2011, U of Massachusetts : Med

URL: https://escholarship.umassmed.edu/gsbs_diss/566

► Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disorder that is the leading genetic cause of infantile death. SMA is caused by homozygous… (more)

▼ Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disorder that is the leading genetic cause of infantile death. SMA is caused by homozygous deletion or mutation of the survival of motor neuron 1 gene (SMN1). The SMN2 gene is nearly identical to SMN1, however is alternatively spliced. The close relationship to SMN1 results in SMN2 being a very power genetic modifier of SMA disease severity and a target for therapies. In this study we attempt to characterize novel chemical compounds identified as potential activators of the SMN2 gene. Additionally, we sought to determine the regulatory role individual HDAC proteins use to control expression of full length protein from the SMN2 gene. We used quantitative PCR to determine the effects of novel compounds and shRNA silencing of individual HDACs on the steady state levels of a SMN2-luciferase reporter transcripts. We determined that the compounds identified in multiple reporter high throughput screens increased SMN protein levels via transcriptional activation of the SMN2 gene. Other compounds identified in the same screen functioned post-transcriptionally, possibly stabilizing the SMN protein itself by decreasing degradation. Furthermore, we determined that reduction of individual HDAC proteins was sufficient to increase SMN protein levels in a transgenic reporter system. Knockdown of class I HDAC proteins preferentially activated the reporter by increased promoter transcription. Silencing of class II HDAC proteins maintained transcriptional activity; however silencing of HDAC 5 and 6 also appeared to enhance inclusion of an alternatively spliced exon. This collective work defines a quantitative RNA based protocol to determine mechanism of SMN reporter increase in response to any chosen treatment method. Additionally, this work highlights HDAC proteins 2 and 6 as excellent investigative targets. These data are important to the basic understanding of SMN expression regulation and the refinements of current therapeutic compounds as well as the development of novel SMA therapeutics. Advisors/Committee Members: Elliot J. Androphy, M.D..

Subjects/Keywords: Muscular Atrophy; Spinal; Survival of Motor Neuron 2 Protein; Histone Deacetylases; Amino Acids, Peptides, and Proteins; Enzymes and Coenzymes; Nervous System Diseases; Neuroscience and Neurobiology; Nucleic Acids, Nucleotides, and Nucleosides; Pathological Conditions, Signs and Symptoms

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APA (6^th Edition):

Evans, M. C. (2011). Quantitative Analysis of Novel Chemical and shRNA Based Methods to Increase Survival of Motor Neuron Protein Levels. (Doctoral Dissertation). U of Massachusetts : Med. Retrieved from https://escholarship.umassmed.edu/gsbs_diss/566

Chicago Manual of Style (16^th Edition):

Evans, Matthew C. “Quantitative Analysis of Novel Chemical and shRNA Based Methods to Increase Survival of Motor Neuron Protein Levels.” 2011. Doctoral Dissertation, U of Massachusetts : Med. Accessed January 17, 2021. https://escholarship.umassmed.edu/gsbs_diss/566.

MLA Handbook (7^th Edition):

Evans, Matthew C. “Quantitative Analysis of Novel Chemical and shRNA Based Methods to Increase Survival of Motor Neuron Protein Levels.” 2011. Web. 17 Jan 2021.

Vancouver:

Evans MC. Quantitative Analysis of Novel Chemical and shRNA Based Methods to Increase Survival of Motor Neuron Protein Levels. [Internet] [Doctoral dissertation]. U of Massachusetts : Med; 2011. [cited 2021 Jan 17]. Available from: https://escholarship.umassmed.edu/gsbs_diss/566.

Council of Science Editors:

Evans MC. Quantitative Analysis of Novel Chemical and shRNA Based Methods to Increase Survival of Motor Neuron Protein Levels. [Doctoral Dissertation]. U of Massachusetts : Med; 2011. Available from: https://escholarship.umassmed.edu/gsbs_diss/566

25. Rozas Afonso, Isabel. Terapia ocupacional y enfermedad de Parkinson .

Degree: 2012, Universidad da Coruña

URL: http://hdl.handle.net/2183/14419

► [Resumen] La Enfermedad de Parkinson (EP) es una enfermedad neurodegenerativa y que a día de hoy no tiene cura; aunque si que se pueden intentar… (more)

Subjects/Keywords: Enfermedad de Parkinson; Terapia ocupacional; Actividades de la vida diaria en la EP; Calidad de vida; Síntomas no motores; Parkinson's disease; Occupational therapy; Activities of daily living; Non motor symptoms; Quality of life

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APA (6^th Edition):

Rozas Afonso, I. (2012). Terapia ocupacional y enfermedad de Parkinson . (Masters Thesis). Universidad da Coruña. Retrieved from http://hdl.handle.net/2183/14419

Chicago Manual of Style (16^th Edition):

Rozas Afonso, Isabel. “Terapia ocupacional y enfermedad de Parkinson .” 2012. Masters Thesis, Universidad da Coruña. Accessed January 17, 2021. http://hdl.handle.net/2183/14419.

MLA Handbook (7^th Edition):

Rozas Afonso, Isabel. “Terapia ocupacional y enfermedad de Parkinson .” 2012. Web. 17 Jan 2021.

Vancouver:

Rozas Afonso I. Terapia ocupacional y enfermedad de Parkinson . [Internet] [Masters thesis]. Universidad da Coruña; 2012. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/2183/14419.

Council of Science Editors:

Rozas Afonso I. Terapia ocupacional y enfermedad de Parkinson . [Masters Thesis]. Universidad da Coruña; 2012. Available from: http://hdl.handle.net/2183/14419

University of Gothenburg / Göteborgs Universitet

26. Rung, Johan. Dopaminergic stabilizers for the treatment of schizophrenia. Rat studies focusing on negative symptoms and mechanisms of action.

Degree: 2007, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/7535

► Schizophrenia is a severe mental disorder manifested by positive, negative and cognitive symptoms. Current antipsychotic drugs have poor effects on negative and cognitive symptoms, thus… (more)

▼ Schizophrenia is a severe mental disorder manifested by positive, negative and cognitive symptoms. Current antipsychotic drugs have poor effects on negative and cognitive symptoms, thus necessitating the development of new antipsychotic treatments. Dopaminergic stabilizers constitute a novel concept for the treatment of schizophrenia. These drugs are claimed to normalize dopaminergic transmission in case of either excessive or deficient signalling. Possibly, such drugs are particularly useful for treating conditions involving both increased and decreased dopaminergic tone, as may be the case in schizophrenia. The present thesis focuses on the dopaminergic stabilizers (-)-OSU6162 and ACR16. The main objectives of this thesis were to 1) test the effects of (-)-OSU6162 and ACR16 in a rat model for negative symptoms, 2) explore their stabilizer properties and 3) shed light on the mechanisms of action of these drugs. (-)-OSU6162 and ACR16 were found to reverse social withdrawal in rats, induced by the NMDA receptor antagonist (+)-MK-801. These results suggest that these drugs may be effective against negative symptoms of schizophrenia. (-)-OSU6162 and ACR16 both had baseline dependent effects on motor activity in drug naïve rats, inhibiting behaviour in rats with a high motor activity level and stimulating behaviour in rats with a low activity level. These effects may be interpreted as support for dopaminergic stabilization. Based on the effects on prolactin secretion observed in the present work and results from studies performed in other laboratories, it appears that (-)-OSU6162, and probably also ACR16, have negligible intrinsic activities at the D2 receptor. Thus, the behavioural inhibition caused by these drugs is probably a result of D2 receptor blockade. The present results suggest that (-)-OSU6162 and ACR16 act via at least two D2-receptor associated targets with opposing actions on dopaminergic transmission. A recent in vitro study suggests that (-)-OSU6162, apart from blocking the orthosteric site, also facilitates receptor activation by binding to an allosteric site at the D2 receptor. This finding provides a candidate for the activating target for (-)-OSU6162 and ACR16.

Subjects/Keywords: ACR16; dopaminergic stabilizers; (+)-MK-801; motor activity; negative symptoms; (-)-OSU6162; prolactin; rat; schizophrenia; social withdrawal

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APA (6^th Edition):

Rung, J. (2007). Dopaminergic stabilizers for the treatment of schizophrenia. Rat studies focusing on negative symptoms and mechanisms of action. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/7535

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rung, Johan. “Dopaminergic stabilizers for the treatment of schizophrenia. Rat studies focusing on negative symptoms and mechanisms of action.” 2007. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed January 17, 2021. http://hdl.handle.net/2077/7535.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rung, Johan. “Dopaminergic stabilizers for the treatment of schizophrenia. Rat studies focusing on negative symptoms and mechanisms of action.” 2007. Web. 17 Jan 2021.

Vancouver:

Rung J. Dopaminergic stabilizers for the treatment of schizophrenia. Rat studies focusing on negative symptoms and mechanisms of action. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2007. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/2077/7535.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rung J. Dopaminergic stabilizers for the treatment of schizophrenia. Rat studies focusing on negative symptoms and mechanisms of action. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2007. Available from: http://hdl.handle.net/2077/7535

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

27. Hutchison, Erika Grear. Nature and Laterality of Motor Symptoms in Parkinson's Disease and Relationships to Cognitive Profile.

Degree: 2013, University of Washington

URL: http://hdl.handle.net/1773/21837

► Previous research suggested that the nature (bradykinesia, rigidity, or tremor) and laterality (left or right-sided) of motor symptoms in Parkinson's disease (PD) are related to… (more)

▼ Previous research suggested that the nature (bradykinesia, rigidity, or tremor) and laterality (left or right-sided) of motor symptoms in Parkinson's disease (PD) are related to cognitive-linguistic profile later in the progression of the disease. Approximately 600 individuals with PD recruited through the Pacific Northwest Udall Center (PANUC) PD Registry were considered for participation. Individuals completed a neuropsychological test battery that assessed language, memory, visuospatial function, and executive function. Three logistic regression models using the same set of input variables were run: a binomial model comparing left versus right side of onset, a binomial model comparing the type of onset symptom, and a multinomial model comparing the right onset group with tremor as the predominant symptom against the three other subgroups defined by laterality and symptom type. In all three regression models, the selected cognitive variables were regressed on subgroups determined by laterality and nature of initial motor symptoms. These subgroups were left bradykinesia/rigidity onset (L-B/RO), left tremor onset (L-TO), right bradykinesia/rigidity onset (R-B/RO), and right tremor onset (R-TO). Chi squared tests revealed that the four subgroups were equivalent with respect to sex, years of education, disease duration and disease severity. Groups were significantly different with respect to age at initial neuropsychological testing, age at disease onset, and Geriatric Depression Scale total score, and these variables were entered as covariates in the regression. Overall, the regression models did not significantly differentiate the left-onset group from the right-onset group or the tremor group from the bradykinesia/rigidity group. However, the regression model with subgroups based on the combination of laterality and symptom type was found to significantly differentiate the L-TO, L-B/RO and R-B/RO subgroups from the R-TO subgroup. This finding suggests that the interaction of laterality at disease onset and nature of motor symptoms is significantly associated with the cognitive-linguistic profile of individuals with PD. Advisors/Committee Members: Spencer, Kristie (advisor).

Subjects/Keywords: bradykinesia; cognitive; laterality; motor symptoms; Parkinson's disease; tremor; Speech therapy; Speech

…and cognition in individuals with Parkinson’s disease The cardinal motor symptoms of PD are… …commonly occurs following the onset of other motor symptoms and results from a loss of postural… …primary motor symptoms (tremor, rigidity, postural instability), the absence of… …with PD into clinical subgroups based on their initial motor symptoms to determine whether… …presentation is considered. Laterality of motor symptoms and cognition in individuals with…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hutchison, E. G. (2013). Nature and Laterality of Motor Symptoms in Parkinson's Disease and Relationships to Cognitive Profile. (Thesis). University of Washington. Retrieved from http://hdl.handle.net/1773/21837

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hutchison, Erika Grear. “Nature and Laterality of Motor Symptoms in Parkinson's Disease and Relationships to Cognitive Profile.” 2013. Thesis, University of Washington. Accessed January 17, 2021. http://hdl.handle.net/1773/21837.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hutchison, Erika Grear. “Nature and Laterality of Motor Symptoms in Parkinson's Disease and Relationships to Cognitive Profile.” 2013. Web. 17 Jan 2021.

Vancouver:

Hutchison EG. Nature and Laterality of Motor Symptoms in Parkinson's Disease and Relationships to Cognitive Profile. [Internet] [Thesis]. University of Washington; 2013. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/1773/21837.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hutchison EG. Nature and Laterality of Motor Symptoms in Parkinson's Disease and Relationships to Cognitive Profile. [Thesis]. University of Washington; 2013. Available from: http://hdl.handle.net/1773/21837

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universitat de Girona

28. Cabezas Llobet, Núria. Therapeutic potential of pituitary adenylate cyclase-activating polypeptide and epigallocatechin gallate in motor and cognitive deficits of Huntington's disease models.

Degree: Departament de Ciències Mèdiques, 2019, Universitat de Girona

URL: http://hdl.handle.net/10803/667119

► La malaltia de Huntington (MH) és un trastorn neurodegeneratiu progressiu caractritzat per una alteració del control motor, per dèficits cognitius i símptomes psiquiàtrics. A nivell… (more)

Subjects/Keywords: Malaltia de Huntington; Huntington disease; Enfermedad de Huntington; Receptor PAC1; PAC1 receptor; Enzim FASN; FASN enzyme; Enzima FASN; Plasticitat sinàptica; Synaptic plasticity; Plasticidad sináptica; Símptomes cognitius i motors; Cognitive and motor symptoms; Síntomas cognitivos y motores; PACAP; Pituitary adenylate cyclase-activating polypeptide; Polipèptid activador de l'adenilat ciclasa; Polipéptido activador de la adenilato ciclasa; EGCG; Epigallocatechin gallate; Epigalocatequina gal·lat; Epigalocatequina galato; 616.8

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APA (6^th Edition):

Cabezas Llobet, N. (2019). Therapeutic potential of pituitary adenylate cyclase-activating polypeptide and epigallocatechin gallate in motor and cognitive deficits of Huntington's disease models. (Thesis). Universitat de Girona. Retrieved from http://hdl.handle.net/10803/667119

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cabezas Llobet, Núria. “Therapeutic potential of pituitary adenylate cyclase-activating polypeptide and epigallocatechin gallate in motor and cognitive deficits of Huntington's disease models.” 2019. Thesis, Universitat de Girona. Accessed January 17, 2021. http://hdl.handle.net/10803/667119.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cabezas Llobet, Núria. “Therapeutic potential of pituitary adenylate cyclase-activating polypeptide and epigallocatechin gallate in motor and cognitive deficits of Huntington's disease models.” 2019. Web. 17 Jan 2021.

Vancouver:

Cabezas Llobet N. Therapeutic potential of pituitary adenylate cyclase-activating polypeptide and epigallocatechin gallate in motor and cognitive deficits of Huntington's disease models. [Internet] [Thesis]. Universitat de Girona; 2019. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10803/667119.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cabezas Llobet N. Therapeutic potential of pituitary adenylate cyclase-activating polypeptide and epigallocatechin gallate in motor and cognitive deficits of Huntington's disease models. [Thesis]. Universitat de Girona; 2019. Available from: http://hdl.handle.net/10803/667119

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

29. Botsjö, Alexandra. Upplevelsen av det dagliga livet med Parkinsons sjukdom : Att leva med en oförutsägbar kropp.

Degree: Health and Welfare, 2019, Halmstad University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-39366

►

Bakgrund: 20 000 personer i Sverige lever med Parkinsons sjukdom. Parkinsons sjukdom är en kronisk, neurologisk sjukdom som karaktäriseras av motoriska och icke-motoriska symtom. De… (more)

▼

Bakgrund: 20 000 personer i Sverige lever med Parkinsons sjukdom. Parkinsons sjukdom är en kronisk, neurologisk sjukdom som karaktäriseras av motoriska och icke-motoriska symtom. De motoriska symtomen försvårar utförandet av aktiviteter i det dagliga livet. Syfte: Syftet var att beskriva hur personer med Parkinsons sjukdom upplever att de motoriska symtomen påverkar det dagliga livet. Metod: En allmänlitteraturöversikt utifrån tio kvalitativa vetenskapliga artiklar. Resultat: En oförutsägbar kropp, förlorad självständighet och begränsning av det sociala livet var tre huvudkategorier som framkom i resultatet med respektive subkategorier. Resultatet visade att personer med Parkinsons sjukdom uttryckte att kroppen var olika från dag till dag vilket stoppade dem i det dagliga livet. Det ledde till en förändrad identitet och en känsla av förlorad självständighet. Konklusion: En ökad kunskap och förståelse för hur det är för personer att leva med Parkinsons sjukdom, kan ge sjuksköterskor möjlighet att bedriva en bättre personcentrerad vård kring personer med Parkinsons sjukdom.

Background: 20 000 people in Sweden are living with Parkinson’s disease. Parkinson´s disease is a chronic neurologic disease characterised by motor and non-motor symptoms. The motor symptoms complicate the performance of activities in everyday life. Aim: The aim of this study was to describe how people with Parkinson’s disease experience how the motor symptoms affect their everyday life. Method: A general literature study based on ten qualitative scientific articles. Results: An unpredictable body, lost independence and limitations of social life was three main categories that emerged in the result with respective subcategories. The result showed that people with Parkinson’s disease expressed that the body was different from day to day, which stopped them in everyday life. This led to a changed identity and a sense of lost independence. Conclusion: An increased understanding in how people with Parkinson`s disease experience life, can give nurses an opportunity to give a better person-centered care to people with Parkinson´s disease.

Subjects/Keywords: Everyday life; Experience; Motor symptoms; Parkinson’s disease; Det dagliga livet; Motoriska symtom; Parkinsons sjukdom; Upplevelser; Medical and Health Sciences; Medicin och hälsovetenskap

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APA (6^th Edition):

Botsjö, A. (2019). Upplevelsen av det dagliga livet med Parkinsons sjukdom : Att leva med en oförutsägbar kropp. (Thesis). Halmstad University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-39366

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Botsjö, Alexandra. “Upplevelsen av det dagliga livet med Parkinsons sjukdom : Att leva med en oförutsägbar kropp.” 2019. Thesis, Halmstad University. Accessed January 17, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-39366.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Botsjö, Alexandra. “Upplevelsen av det dagliga livet med Parkinsons sjukdom : Att leva med en oförutsägbar kropp.” 2019. Web. 17 Jan 2021.

Vancouver:

Botsjö A. Upplevelsen av det dagliga livet med Parkinsons sjukdom : Att leva med en oförutsägbar kropp. [Internet] [Thesis]. Halmstad University; 2019. [cited 2021 Jan 17]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-39366.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Botsjö A. Upplevelsen av det dagliga livet med Parkinsons sjukdom : Att leva med en oförutsägbar kropp. [Thesis]. Halmstad University; 2019. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-39366

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations