You searched for subject:(mild cognitive impairment).
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McMaster University
1.
Turner, Laura Elizabeth.
Occupational Performance and Mild Cognitive Impairment in a Primary Care Memory Clinic.
Degree: MSc, 2014, McMaster University
URL: http://hdl.handle.net/11375/16152 
► As Ontario faces a major shift in demographics, it is anticipated that the number of community-dwelling people living with cognitive impairment will increase significantly. Occupational…
(more)
▼ As Ontario faces a major shift in demographics, it is anticipated that the number of community-dwelling people living with cognitive impairment will increase significantly. Occupational therapists (OTs) may play a key role in ensuring timely diagnosis and/or informing a comprehensive plan of care for this population by assessing and reporting on functional abilities. The purpose of this study was to explore the impact of an OT home assessment on diagnosis and plan of care for persons with Mild Cognitive Impairment (MCI) in a primary care Memory Clinic setting using a before and after design. A toolkit of clinical measures was developed to assess self-perception of occupational performance, instrumental activities of daily living (IADLs), falls risk and home safety. Thirty-one participants who had been assessed by a Memory Clinic team completed a one-hour OT home assessment focused on these attributes. A change in the plan of care was proposed for 24 of 31 participants (i.e., 77%) after the assessment findings were reviewed by the lead physicians of three Memory Clinic teams. Clinical information from an OT home assessment was used by the Memory Clinic teams to change follow-up visit times, plan diagnosis and/or medication review and initiate additional community supports for persons with MCI. Women in this sample were more likely than men to experience changes to their plan of care and were also at a higher falls risk as indicated by scores on a screening tool of this attribute. Several time sensitive issues were identified during the OT home assessment including falls risk, home safety issues and participant concern with driving ability. The addition of an OT home visit to an existing Memory Clinic Model has the potential to change the overall plan of care and to identify issues that may impact overall health and wellness, and the ability to live well at home. While the context for this study was an existing Memory Clinic Model in primary care, the findings have implications for older adults in any health setting who are experiencing cognitive changes.
Thesis
Master of Science Rehabilitation Science (MSc)
Advisors/Committee Members: Law, Mary, Letts, Lori, Lee, Linda, Rehabilitation Science.
Subjects/Keywords: occupational therapy; mild cognitive impairment
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APA (6th Edition):
Turner, L. E. (2014). Occupational Performance and Mild Cognitive Impairment in a Primary Care Memory Clinic. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/16152
Chicago Manual of Style (16th Edition):
Turner, Laura Elizabeth. “Occupational Performance and Mild Cognitive Impairment in a Primary Care Memory Clinic.” 2014. Masters Thesis, McMaster University. Accessed January 17, 2021.
http://hdl.handle.net/11375/16152.
MLA Handbook (7th Edition):
Turner, Laura Elizabeth. “Occupational Performance and Mild Cognitive Impairment in a Primary Care Memory Clinic.” 2014. Web. 17 Jan 2021.
Vancouver:
Turner LE. Occupational Performance and Mild Cognitive Impairment in a Primary Care Memory Clinic. [Internet] [Masters thesis]. McMaster University; 2014. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/11375/16152.
Council of Science Editors:
Turner LE. Occupational Performance and Mild Cognitive Impairment in a Primary Care Memory Clinic. [Masters Thesis]. McMaster University; 2014. Available from: http://hdl.handle.net/11375/16152
University of Toronto
2.
Newsome, Rachel.
Attentional Selection and Reduced Interference Improve Visual Short-term Memory in Mild Cognitive Impairment.
Degree: 2011, University of Toronto
URL: http://hdl.handle.net/1807/31358
► Visual short-term memory (VSTM) is a vital cognitive ability, allowing us to hold online the contents of visual awareness. Healthy older adults have reduced VSTM…
(more)
▼ Visual short-term memory (VSTM) is a vital cognitive ability, allowing us to hold online the contents of visual awareness. Healthy older adults have reduced VSTM capacity compared to young adults; however recent evidence suggests that their performance may be improved by the use of a retroactive cue (“retro-cue”). The retro-cue reduces interference from irrelevant items within VSTM. Mild cognitive impairment (MCI) patients have reduced VSTM performance, compared to healthy older adults. Here, we examined whether the use of a retro-cue would increase VSTM capacity in MCI patients. By presenting a retro-cue after a to-be remembered array, we direct attention to the to-be probed location, which reduces interference from other items that are no longer relevant. The present findings suggest that VSTM capacity per se is not compromised in MCI patients, but these patients may be more susceptible to the effects of interference.
MAST
Advisors/Committee Members: Barense, Morgan, Psychology.
Subjects/Keywords: Memory; Mild Cognitive Impairment
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APA (6th Edition):
Newsome, R. (2011). Attentional Selection and Reduced Interference Improve Visual Short-term Memory in Mild Cognitive Impairment. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/31358
Chicago Manual of Style (16th Edition):
Newsome, Rachel. “Attentional Selection and Reduced Interference Improve Visual Short-term Memory in Mild Cognitive Impairment.” 2011. Masters Thesis, University of Toronto. Accessed January 17, 2021.
http://hdl.handle.net/1807/31358.
MLA Handbook (7th Edition):
Newsome, Rachel. “Attentional Selection and Reduced Interference Improve Visual Short-term Memory in Mild Cognitive Impairment.” 2011. Web. 17 Jan 2021.
Vancouver:
Newsome R. Attentional Selection and Reduced Interference Improve Visual Short-term Memory in Mild Cognitive Impairment. [Internet] [Masters thesis]. University of Toronto; 2011. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/1807/31358.
Council of Science Editors:
Newsome R. Attentional Selection and Reduced Interference Improve Visual Short-term Memory in Mild Cognitive Impairment. [Masters Thesis]. University of Toronto; 2011. Available from: http://hdl.handle.net/1807/31358
University of Manchester
3.
Karim, Salman.
Peripheral and central markers of inflammation in mild
cognitive impairment.
Degree: 2011, University of Manchester
URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:138972
► There has been accumulating scientific evidence, over the last three decades, of the role of inflammatory processes in the development of Alzheimer’s disease (AD). Population…
(more)
▼ There has been accumulating scientific evidence,
over the last three decades, of the role of inflammatory processes
in the development of Alzheimer’s disease (AD). Population based
studies suggest that plasma levels of inflammatory markers are
raised in peripheral blood of people with AD. People on long term
use of non-steroidal anti-inflammatory drugs have a lower
prevalence of AD. Moreover, both animal and human histopathology
studies have reported localization of inflammation in brain areas
primarily affected by AD pathology. Areas of increased inflammation
can be visualized in vivo by Positron Emission Tomography (PET)
scans using the PK11195 ligand that binds with the benzodiazepine
receptor sites of activated microglial cells. Cognitive decline in
AD has been shown to correlate with levels of microglial activation
using PK11195 PET scans. People with amnestic mild cognitive
impairment (MCI) are known to be at high risk of developing AD.We
aimed to investigate the association between peripheral and central
markers of inflammation and cognitive decline in a group of people
with amnestic MCI.MCI subjects (n=70) underwent cognitive testing,
IL-6 and CRP in peripheral blood were measured and repeated after 1
year. A sub group (n=15) was followed up for another year and
central brain microglial activation was measured by PET using
PK11195 along with cognitive and peripheral inflammatory marker
measurement.The mean CRP and IL-6 levels of the cohort increased
over one year but the rise was only significant for CRP. No
association was detected between inflammatory markers levels and
cognition as measured by a battery of cognitive instruments. Group
comparisons of the PET cohort with healthy controls (n=5) showed
increased PK11195 binding (mean binding potential) in frontal lobe,
temporal lobe, parietal lobe, putamen, occipital lobes and
significantly increased binding in posterior cingulate gyrus. This
study, to our knowledge, is unique in studying makers of
inflammation in amnestic MCI participants both in peripheral blood
and brain. The results of this study, in the light of current
literature, add to the importance of recognition of inflammatory
processes in people at risk of developing AD. The results suggest
that CRP levels rise significantly over time and are detectable in
peripheral blood by using practically simple laboratory techniques.
The results also suggest that activated microglia in amnestic MCI
patients can be visualized in vivo by using PK11195 PET scans and
show higher levels of activation as compared to healthy controls.
These finding could be useful in identifying people with
malactivated (pro-inflammatory) microglia as potential targets for
prevention/early treatment strategies. Further studies with larger
samples sizes and long term follow-up are needed to investigate
whether these peripheral and central inflammatory markers could
shed light on the aetiology of AD and be useful in monitoring
disease progression.
Subjects/Keywords: Mild cognitive impairment; Inflammation
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APA ·
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Manager
APA (6th Edition):
Karim, S. (2011). Peripheral and central markers of inflammation in mild
cognitive impairment. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:138972
Chicago Manual of Style (16th Edition):
Karim, Salman. “Peripheral and central markers of inflammation in mild
cognitive impairment.” 2011. Doctoral Dissertation, University of Manchester. Accessed January 17, 2021.
http://www.manchester.ac.uk/escholar/uk-ac-man-scw:138972.
MLA Handbook (7th Edition):
Karim, Salman. “Peripheral and central markers of inflammation in mild
cognitive impairment.” 2011. Web. 17 Jan 2021.
Vancouver:
Karim S. Peripheral and central markers of inflammation in mild
cognitive impairment. [Internet] [Doctoral dissertation]. University of Manchester; 2011. [cited 2021 Jan 17].
Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:138972.
Council of Science Editors:
Karim S. Peripheral and central markers of inflammation in mild
cognitive impairment. [Doctoral Dissertation]. University of Manchester; 2011. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:138972
University of Manchester
4.
Karim, Salman.
Peripheral and central markers of inflammation in mild cognitive impairment.
Degree: Thesis (M.D.), 2011, University of Manchester
URL: https://www.research.manchester.ac.uk/portal/en/theses/peripheral-and-central-markers-of-inflammation-in-mild-cognitive-impairment(bd21dafe-65c1-42c9-949b-733abfc71037).html
;
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553346
► There has been accumulating scientific evidence, over the last three decades, of the role of inflammatory processes in the development of Alzheimer's disease (AD). Population…
(more)
▼ There has been accumulating scientific evidence, over the last three decades, of the role of inflammatory processes in the development of Alzheimer's disease (AD). Population based studies suggest that plasma levels of inflammatory markers are raised in peripheral blood of people with AD. People on long term use of non-steroidal anti-inflammatory drugs have a lower prevalence of AD. Moreover, both animal and human histopathology studies have reported localization of inflammation in brain areas primarily affected by AD pathology. Areas of increased inflammation can be visualized in vivo by Positron Emission Tomography (PET) scans using the PK11195 ligand that binds with the benzodiazepine receptor sites of activated microglial cells. Cognitive decline in AD has been shown to correlate with levels of microglial activation using PK11195 PET scans. People with amnestic mild cognitive impairment (MCI) are known to be at high risk of developing AD.We aimed to investigate the association between peripheral and central markers of inflammation and cognitive decline in a group of people with amnestic MCI.MCI subjects (n=70) underwent cognitive testing, IL-6 and CRP in peripheral blood were measured and repeated after 1 year. A sub group (n=15) was followed up for another year and central brain microglial activation was measured by PET using PK11195 along with cognitive and peripheral inflammatory marker measurement. The mean CRP and IL-6 levels of the cohort increased over one year but the rise was only significant for CRP. No association was detected between inflammatory markers levels and cognition as measured by a battery of cognitive instruments. Group comparisons of the PET cohort with healthy controls (n=5) showed increased PK11195 binding (mean binding potential) in frontal lobe, temporal lobe, parietal lobe, putamen, occipital lobes and significantly increased binding in posterior cingulate gyrus. This study, to our knowledge, is unique in studying makers of inflammation in amnestic MCI participants both in peripheral blood and brain. The results of this study, in the light of current literature, add to the importance of recognition of inflammatory processes in people at risk of developing AD. The results suggest that CRP levels rise significantly over time and are detectable in peripheral blood by using practically simple laboratory techniques. The results also suggest that activated microglia in amnestic MCI patients can be visualized in vivo by using PK11195 PET scans and show higher levels of activation as compared to healthy controls. These finding could be useful in identifying people with malactivated (pro-inflammatory) microglia as potential targets for prevention/early treatment strategies. Further studies with larger samples sizes and long term follow-up are needed to investigate whether these peripheral and central inflammatory markers could shed light on the aetiology of AD and be useful in monitoring disease progression.
Subjects/Keywords: 616.831; Mild cognitive impairment; Inflammation
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APA ·
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CSE |
Export
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Manager
APA (6th Edition):
Karim, S. (2011). Peripheral and central markers of inflammation in mild cognitive impairment. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/peripheral-and-central-markers-of-inflammation-in-mild-cognitive-impairment(bd21dafe-65c1-42c9-949b-733abfc71037).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553346
Chicago Manual of Style (16th Edition):
Karim, Salman. “Peripheral and central markers of inflammation in mild cognitive impairment.” 2011. Doctoral Dissertation, University of Manchester. Accessed January 17, 2021.
https://www.research.manchester.ac.uk/portal/en/theses/peripheral-and-central-markers-of-inflammation-in-mild-cognitive-impairment(bd21dafe-65c1-42c9-949b-733abfc71037).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553346.
MLA Handbook (7th Edition):
Karim, Salman. “Peripheral and central markers of inflammation in mild cognitive impairment.” 2011. Web. 17 Jan 2021.
Vancouver:
Karim S. Peripheral and central markers of inflammation in mild cognitive impairment. [Internet] [Doctoral dissertation]. University of Manchester; 2011. [cited 2021 Jan 17].
Available from: https://www.research.manchester.ac.uk/portal/en/theses/peripheral-and-central-markers-of-inflammation-in-mild-cognitive-impairment(bd21dafe-65c1-42c9-949b-733abfc71037).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553346.
Council of Science Editors:
Karim S. Peripheral and central markers of inflammation in mild cognitive impairment. [Doctoral Dissertation]. University of Manchester; 2011. Available from: https://www.research.manchester.ac.uk/portal/en/theses/peripheral-and-central-markers-of-inflammation-in-mild-cognitive-impairment(bd21dafe-65c1-42c9-949b-733abfc71037).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553346
Georgia State University
5.
Stern, Susan.
Psychometric Properties of the Saint Louis University Mental Status Examination (SLUMS) for the Identification of Mild Cognitive Impairment (MCI) in a Veteran Sample.
Degree: PhD, Psychology, 2014, Georgia State University
URL: https://scholarworks.gsu.edu/psych_diss/125
► The Saint Louis University Mental Status (SLUMS) Examination is a relatively new brief cognitive screening measure developed for use with veterans. To date, there…
(more)
▼ The Saint Louis University Mental Status (SLUMS) Examination is a relatively new brief
cognitive screening measure developed for use with veterans. To date, there has been a paucity of research on its psychometric properties. Using a sample of 148 male veterans referred to a VA
Mild Cognitive Impairment (MCI) Clinic for evaluation, the SLUMS’ ability to discriminate between MCI versus other diagnoses or no diagnosis was compared to results from a more comprehensive neuropsychological battery. Approximately 51% of the sample was diagnosed with MCI, 16% with Major Depressive Disorder (MDD), 17% did not meet criteria for a diagnosis, and 16% were given some other DSM-IV-TR diagnosis. The SLUMS demonstrated poor internal consistency (Cronbach’s alpha = .57), but scores were significantly correlated with scores on every neuropsychological measure, except for Trails B. Diagnostic discriminability was comparable to that of the more time intensive neuropsychological battery for discriminating between MCI and no diagnosis, and MCI and MDD. In the current sample, a cutoff score of 25 was optimal for discriminating between MCI and no diagnosis, whereas a slightly lower cutoff score of 24 is recommended for discriminating between MCI and those with MDD. Diagnostic indicators were poor for the SLUMS and the battery when discriminating between MCI and a heterogeneous group of other disorders. Possible reasons for low reliability in such a screening measure in the context of convergent validity are discussed. It is concluded that the SLUMS may be a viable brief
cognitive screening measure in such veteran populations, particularly when discriminating between MCI and MDD; however, additional studies should be completed to evaluate other forms of consistency, such as test-retest reliability.
Advisors/Committee Members: Robin D. Morris, PhD, Suzanne Penna, PhD, ABPP-Cn, Erin Tone, PhD, Lindsey Cohen, PhD, David Washburn, PhD.
Subjects/Keywords: Cognitive screening; Mild cognitive impairment; SLUMS
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APA ·
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MLA ·
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Manager
APA (6th Edition):
Stern, S. (2014). Psychometric Properties of the Saint Louis University Mental Status Examination (SLUMS) for the Identification of Mild Cognitive Impairment (MCI) in a Veteran Sample. (Doctoral Dissertation). Georgia State University. Retrieved from https://scholarworks.gsu.edu/psych_diss/125
Chicago Manual of Style (16th Edition):
Stern, Susan. “Psychometric Properties of the Saint Louis University Mental Status Examination (SLUMS) for the Identification of Mild Cognitive Impairment (MCI) in a Veteran Sample.” 2014. Doctoral Dissertation, Georgia State University. Accessed January 17, 2021.
https://scholarworks.gsu.edu/psych_diss/125.
MLA Handbook (7th Edition):
Stern, Susan. “Psychometric Properties of the Saint Louis University Mental Status Examination (SLUMS) for the Identification of Mild Cognitive Impairment (MCI) in a Veteran Sample.” 2014. Web. 17 Jan 2021.
Vancouver:
Stern S. Psychometric Properties of the Saint Louis University Mental Status Examination (SLUMS) for the Identification of Mild Cognitive Impairment (MCI) in a Veteran Sample. [Internet] [Doctoral dissertation]. Georgia State University; 2014. [cited 2021 Jan 17].
Available from: https://scholarworks.gsu.edu/psych_diss/125.
Council of Science Editors:
Stern S. Psychometric Properties of the Saint Louis University Mental Status Examination (SLUMS) for the Identification of Mild Cognitive Impairment (MCI) in a Veteran Sample. [Doctoral Dissertation]. Georgia State University; 2014. Available from: https://scholarworks.gsu.edu/psych_diss/125
University of New South Wales
6.
Finn, Maurice.
COMPUTERISED COGNITIVE TRAINING FOR OLDER PERSONS WITH MILD COGNITIVE IMPAIRMENT.
Degree: Psychology, 2014, University of New South Wales
URL: http://handle.unsw.edu.au/1959.4/53517
;
https://unsworks.unsw.edu.au/fapi/datastream/unsworks:12212/SOURCE02?view=true
► Mild Cognitive Impairment (MCI) is understood as an intermediate state between normal ageing and dementia. It is a heterogeneous entity with varying presentations and outcomes.…
(more)
▼ Mild Cognitive Impairment (MCI) is understood as an intermediate state between normal ageing and dementia. It is a heterogeneous entity with varying presentations and outcomes. MCI is associated with both underlying neuropathology and functional changes.
Mild Cognitive Impairment is a controversial term with problems with both the definition and the stability of the condition. However, there remains a significant risk of developing dementia over a period of five years. The problems encountered by people with MCI are significant and problematic in everyday life. Efforts to treat MCI are in their infancy, with no proven pharmacological agents available, and a paucity of well-designed behavioural intervention studies. Most behavioural efforts have focussed on teaching memory strategies but a more recent approach seeks to ameliorate
cognitive decline via
cognitive exercises. This approach draws on evidence of the protective benefit of
cognitive stimulation and the plasticity in the ageing brain to argue that a program of
cognitive exercises delivered to an impaired sample may provide measurable benefits. The evidence for this proposition is reviewed and three studies are described that attempted to improve cognition in a group of people with MCI. The findings are discussed in the context of emerging research that suggests a number of avenues to more precisely target
cognitive exercises.
Advisors/Committee Members: McDonald, Skye, Psychology, Faculty of Science, UNSW.
Subjects/Keywords: Mild cognitive impairment; Cognitive training; Elderly; Computerised
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APA ·
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Manager
APA (6th Edition):
Finn, M. (2014). COMPUTERISED COGNITIVE TRAINING FOR OLDER PERSONS WITH MILD COGNITIVE IMPAIRMENT. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/53517 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:12212/SOURCE02?view=true
Chicago Manual of Style (16th Edition):
Finn, Maurice. “COMPUTERISED COGNITIVE TRAINING FOR OLDER PERSONS WITH MILD COGNITIVE IMPAIRMENT.” 2014. Doctoral Dissertation, University of New South Wales. Accessed January 17, 2021.
http://handle.unsw.edu.au/1959.4/53517 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:12212/SOURCE02?view=true.
MLA Handbook (7th Edition):
Finn, Maurice. “COMPUTERISED COGNITIVE TRAINING FOR OLDER PERSONS WITH MILD COGNITIVE IMPAIRMENT.” 2014. Web. 17 Jan 2021.
Vancouver:
Finn M. COMPUTERISED COGNITIVE TRAINING FOR OLDER PERSONS WITH MILD COGNITIVE IMPAIRMENT. [Internet] [Doctoral dissertation]. University of New South Wales; 2014. [cited 2021 Jan 17].
Available from: http://handle.unsw.edu.au/1959.4/53517 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:12212/SOURCE02?view=true.
Council of Science Editors:
Finn M. COMPUTERISED COGNITIVE TRAINING FOR OLDER PERSONS WITH MILD COGNITIVE IMPAIRMENT. [Doctoral Dissertation]. University of New South Wales; 2014. Available from: http://handle.unsw.edu.au/1959.4/53517 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:12212/SOURCE02?view=true
University of Rochester
7.
Johnson, Melissa A.; Hauenstein, Emily.
Self-Perception of Language Abilities in Older
Adults.
Degree: PhD, 2016, University of Rochester
URL: http://hdl.handle.net/1802/31550
► Purpose: To examine awareness of language abilities in cognitively healthy older adults and those with cognitive decline. Methods: A conceptual model of Awareness of Language…
(more)
▼ Purpose: To examine awareness of language abilities
in cognitively healthy older adults and those with cognitive
decline.
Methods: A conceptual model of Awareness of Language
Abilities (ALA) was developed to contribute to the limited existing
research and to provide a framework for the analyses for this study
and for future research. A descriptive, longitudinal secondary data
analysis using the Alzheimer’s Disease Neuroimaging Initiative
dataset was conducted, incorporating a series of generalized
estimating equations to model the relationship between language
abilities and self-perception of language performance across
cognitive subgroups.
Results: Within-group results: All
subgroups showed measureable declines in language abilities;
however, none of the groups showed measurable decline in
self-perception of language performance over time.
Between-group
results: There were significant between-group differences in
language abilities and self-perception of language performance at
baseline. Adults in the Alzheimer’s disease (AD) group declined the
fastest.
Interaction between objective language abilities and
self-perception of language performance: Compared to healthy
elders, those with mild cognitive impairment underestimated their
language abilities; those with AD overestimated their language
abilities.
Individual characteristics related to self-perception
of language abilities: Presence of depressive symptoms was
negatively correlated with and was the only individual
characteristic associated with self-perception of language
performance.
Results situated within ALA model: The ALA model
partially explained awareness of language abilities, but is in need
of revision and further research.
Clinical and Research
Implications: These findings have important implications for
assisting older adults in optimizing safety, decision-making and
quality of life. When language deficits are present and awareness
is high, older adults may socially withdraw, thereby accelerating
decline. They may benefit from interventions to promote meaningful
linguistically-rich social interactions. When language deficits are
significant and awareness is low, older adults may profit from
interventions to support communication of important linguistic
content. Further research, guided by the ALA model, is needed to
further clinical and theoretical understanding of awareness of
language abilities.
Conclusions: Awareness of language abilities
has the potential to moderate the effects of language deficits by
providing an opportunity for compensation. If awareness is impaired
as a function of cognitive decline, opportunities for compensation
can be lost.
Subjects/Keywords: Language; Awareness; Aging; Dementia; Mild cognitive impairment
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Manager
APA (6th Edition):
Johnson, Melissa A.; Hauenstein, E. (2016). Self-Perception of Language Abilities in Older
Adults. (Doctoral Dissertation). University of Rochester. Retrieved from http://hdl.handle.net/1802/31550
Chicago Manual of Style (16th Edition):
Johnson, Melissa A.; Hauenstein, Emily. “Self-Perception of Language Abilities in Older
Adults.” 2016. Doctoral Dissertation, University of Rochester. Accessed January 17, 2021.
http://hdl.handle.net/1802/31550.
MLA Handbook (7th Edition):
Johnson, Melissa A.; Hauenstein, Emily. “Self-Perception of Language Abilities in Older
Adults.” 2016. Web. 17 Jan 2021.
Vancouver:
Johnson, Melissa A.; Hauenstein E. Self-Perception of Language Abilities in Older
Adults. [Internet] [Doctoral dissertation]. University of Rochester; 2016. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/1802/31550.
Council of Science Editors:
Johnson, Melissa A.; Hauenstein E. Self-Perception of Language Abilities in Older
Adults. [Doctoral Dissertation]. University of Rochester; 2016. Available from: http://hdl.handle.net/1802/31550
University of Alberta
8.
Whitehead, Bonnie P.
CLU, CR1 and PICALM: Genotypic Effects on Mild Cognitive
Impairment Status and Stability.
Degree: MS, Department of Psychology, 2013, University of Alberta
URL: https://era.library.ualberta.ca/files/cr56n130f
► Objective: Clinical utility of the Mild Cognitive Impairment (MCI) classification is diminished by uncertainty regarding procedures for detecting preceding transitions from normal aging (NA) and…
(more)
▼ Objective: Clinical utility of the Mild Cognitive
Impairment (MCI) classification is diminished by uncertainty
regarding procedures for detecting preceding transitions from
normal aging (NA) and future transitions
to Alzheimer’s disease (AD). AD genetic markers may
clarify underlying neurodegenerative etiology, thereby improving
MCI classification. Method: Data are from the Victoria Longitudinal
Study. We determine if AD-related genotypes [Apolipoprotein E
(APOE; rs429358, rs7412), Clusterin (CLU; rs11136000), Complement
Receptor 1 (CR1; rs6656401), Phosphatidylinositol Binding Clathrin
Assembly Protein (PICALM; rs541458)] independently or interactively
distinguish (a) MCI (n=101) and NA adults (n=136) at baseline, and
(b) longitudinal groups representing two- wave (M=4.5 years)
profiles of MCI chronicity and change. Results: CLU and APOE
independently predicted baseline MCI. Each gene independently
differentiated one combination of longitudinal profiles. The CR1(2)
x APOE(2) interaction differentiated numerous longitudinal
profiles. Discussion: AD genetic markers are linked with
transitions and chronicity involving NA and MCI, and may augment
current MCI classification procedures.
Subjects/Keywords: CLU; PICALM; Mild Cognitive Impairment; CR1; Aging
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APA (6th Edition):
Whitehead, B. P. (2013). CLU, CR1 and PICALM: Genotypic Effects on Mild Cognitive
Impairment Status and Stability. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/cr56n130f
Chicago Manual of Style (16th Edition):
Whitehead, Bonnie P. “CLU, CR1 and PICALM: Genotypic Effects on Mild Cognitive
Impairment Status and Stability.” 2013. Masters Thesis, University of Alberta. Accessed January 17, 2021.
https://era.library.ualberta.ca/files/cr56n130f.
MLA Handbook (7th Edition):
Whitehead, Bonnie P. “CLU, CR1 and PICALM: Genotypic Effects on Mild Cognitive
Impairment Status and Stability.” 2013. Web. 17 Jan 2021.
Vancouver:
Whitehead BP. CLU, CR1 and PICALM: Genotypic Effects on Mild Cognitive
Impairment Status and Stability. [Internet] [Masters thesis]. University of Alberta; 2013. [cited 2021 Jan 17].
Available from: https://era.library.ualberta.ca/files/cr56n130f.
Council of Science Editors:
Whitehead BP. CLU, CR1 and PICALM: Genotypic Effects on Mild Cognitive
Impairment Status and Stability. [Masters Thesis]. University of Alberta; 2013. Available from: https://era.library.ualberta.ca/files/cr56n130f
University of Tasmania
9.
Klekociuk, S.
Longitudinal profiling of mild cognitive impairment subtypes.
Degree: 2013, University of Tasmania
URL: https://eprints.utas.edu.au/18256/1/front-Klekociuk-thesis.pdf
;
https://eprints.utas.edu.au/18256/2/Whole-Klekociuk-thesis-excluding-pub-mat.pdf
;
https://eprints.utas.edu.au/18256/3/Whole-Klekociuk-thesis-inc-pub-mat.pdf
;
https://eprints.utas.edu.au/18256/10/Appendix%20A.zip
;
https://eprints.utas.edu.au/18256/11/Appendix%20B.zip
;
https://eprints.utas.edu.au/18256/12/Appendix%20C.zip
;
https://eprints.utas.edu.au/18256/13/Appendix%20D.zip
► Mild Cognitive Impairment (MCI) was originally conceptualized as a condition that manifested prior to the onset of clinical dementia, particularly Alzheimer’s disease. However, longitudinal studies…
(more)
▼ Mild Cognitive Impairment (MCI) was originally conceptualized as a condition that
manifested prior to the onset of clinical dementia, particularly Alzheimer’s disease. However,
longitudinal studies show that MCI has an unstable course and may lead to various outcomes
including dementia, but also stability of cognitive deficits or recovery to age appropriate
levels of functioning. As a result, the status of MCI as a genuine diagnostic entity remains
questionable. The aim of the present thesis was to examine the validity of the MCI concept
by tracking groups of individuals classified into one of the MCI subtypes and to monitor their
neuropsychological profiles over time. To avoid previous criticisms of circularity,
participants were classified as MCI on a neuropsychological test battery and then reassessed
longitudinally using an alternate battery of neuropsychological tests. At each stage of testing,
participants were assessed on a comprehensive neuropsychological test battery tapping the
cognitive domains implicated in MCI. Findings from this thesis indicate that multiple domain
amnestic MCI may be the most valid subtype of MCI due to consistently poor performance
over time on a range of neuropsychological measures. Results also demonstrate that those
who are likely to remain on the MCI spectrum can be differentiated from healthy older adults
using reliable and valid measures of sustained attention, semantic memory, verbal episodic
memory, visual and verbal working memory, selective attention and strategy use. Despite
these findings, evidence from this thesis indicates that existing MCI clinical criteria lack
sufficient sensitivity and specificity. Although the concept of MCI remains useful, it cannot
be considered a clinical diagnostic entity. Future research should prioritize the observation of
those presenting with a multiple domain amnestic profile as these individuals may have the
poorest prognosis. Further, studies must utilize comprehensive testing protocols to increase
the sensitivity and specificity of identifying those with genuine subclinical impairments.
Subjects/Keywords: mild cognitive impairment; Aging; Alzheimers disease; Neuropsychology
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APA (6th Edition):
Klekociuk, S. (2013). Longitudinal profiling of mild cognitive impairment subtypes. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/18256/1/front-Klekociuk-thesis.pdf ; https://eprints.utas.edu.au/18256/2/Whole-Klekociuk-thesis-excluding-pub-mat.pdf ; https://eprints.utas.edu.au/18256/3/Whole-Klekociuk-thesis-inc-pub-mat.pdf ; https://eprints.utas.edu.au/18256/10/Appendix%20A.zip ; https://eprints.utas.edu.au/18256/11/Appendix%20B.zip ; https://eprints.utas.edu.au/18256/12/Appendix%20C.zip ; https://eprints.utas.edu.au/18256/13/Appendix%20D.zip
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Klekociuk, S. “Longitudinal profiling of mild cognitive impairment subtypes.” 2013. Thesis, University of Tasmania. Accessed January 17, 2021.
https://eprints.utas.edu.au/18256/1/front-Klekociuk-thesis.pdf ; https://eprints.utas.edu.au/18256/2/Whole-Klekociuk-thesis-excluding-pub-mat.pdf ; https://eprints.utas.edu.au/18256/3/Whole-Klekociuk-thesis-inc-pub-mat.pdf ; https://eprints.utas.edu.au/18256/10/Appendix%20A.zip ; https://eprints.utas.edu.au/18256/11/Appendix%20B.zip ; https://eprints.utas.edu.au/18256/12/Appendix%20C.zip ; https://eprints.utas.edu.au/18256/13/Appendix%20D.zip.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Klekociuk, S. “Longitudinal profiling of mild cognitive impairment subtypes.” 2013. Web. 17 Jan 2021.
Vancouver:
Klekociuk S. Longitudinal profiling of mild cognitive impairment subtypes. [Internet] [Thesis]. University of Tasmania; 2013. [cited 2021 Jan 17].
Available from: https://eprints.utas.edu.au/18256/1/front-Klekociuk-thesis.pdf ; https://eprints.utas.edu.au/18256/2/Whole-Klekociuk-thesis-excluding-pub-mat.pdf ; https://eprints.utas.edu.au/18256/3/Whole-Klekociuk-thesis-inc-pub-mat.pdf ; https://eprints.utas.edu.au/18256/10/Appendix%20A.zip ; https://eprints.utas.edu.au/18256/11/Appendix%20B.zip ; https://eprints.utas.edu.au/18256/12/Appendix%20C.zip ; https://eprints.utas.edu.au/18256/13/Appendix%20D.zip.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Klekociuk S. Longitudinal profiling of mild cognitive impairment subtypes. [Thesis]. University of Tasmania; 2013. Available from: https://eprints.utas.edu.au/18256/1/front-Klekociuk-thesis.pdf ; https://eprints.utas.edu.au/18256/2/Whole-Klekociuk-thesis-excluding-pub-mat.pdf ; https://eprints.utas.edu.au/18256/3/Whole-Klekociuk-thesis-inc-pub-mat.pdf ; https://eprints.utas.edu.au/18256/10/Appendix%20A.zip ; https://eprints.utas.edu.au/18256/11/Appendix%20B.zip ; https://eprints.utas.edu.au/18256/12/Appendix%20C.zip ; https://eprints.utas.edu.au/18256/13/Appendix%20D.zip
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Texas Southwestern Medical Center
10.
Rao, Shruthi.
Analysis of Practice Effects Across Cognitive Domains in Mild Cognitive Impairment.
Degree: 2014, University of Texas Southwestern Medical Center
URL: http://hdl.handle.net/2152.5/1441
► Serial assessments provide clinically useful information about progression of a disease. Since individuals with mild cognitive impairment are less likely to show decline in cognitive…
(more)
▼ Serial assessments provide clinically useful information about progression of a disease. Since individuals with
mild cognitive impairment are less likely to show decline in
cognitive areas other than memory, it is important to analyze which domains are more susceptible to practice effects than others.
The appearance of practice effects in serial assessments is a common challenge for clinicians interpreting neuropsychological tests. Detecting true change can be altered by factors such as test intervals, standardization procedures, alternate forms, respondent characteristics, and
cognitive domains impaired in a clinical population. Some
cognitive domains such as learning, memory, and executive functioning are known to be more susceptible to practice effects than others such as processing speed, attention, and language. Normal adults are also shown to have greater practice effects over multiple exposures than disease populations.
The review supports the claim that healthy adult individuals are more likely to improve and show greater practice effects during serial assessments than clinical populations. In patients with
mild cognitive impairment (MCI), domains that rely on recall and learning test rules like learning, memory, and executive functioning tend to be more susceptible to practice effects than crystallized and skill - based domains such as language, processing speed, and attention.
Future research should focus on developing reliable change indices for each
cognitive domain and possibly each neuropsychological test to help provide a comparison and detect true change in test scores. Studies should also focus on developing alternate equivalent forms, which would help minimize practice effects across populations.
Advisors/Committee Members: Lacritz, Laura, Cullum, C. Munro, Martin-Cook, Kristin.
Subjects/Keywords: Learning; Mild Cognitive Impairment; Neuropsychological Tests
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APA ·
Chicago ·
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Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Rao, S. (2014). Analysis of Practice Effects Across Cognitive Domains in Mild Cognitive Impairment. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/1441
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Rao, Shruthi. “Analysis of Practice Effects Across Cognitive Domains in Mild Cognitive Impairment.” 2014. Thesis, University of Texas Southwestern Medical Center. Accessed January 17, 2021.
http://hdl.handle.net/2152.5/1441.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Rao, Shruthi. “Analysis of Practice Effects Across Cognitive Domains in Mild Cognitive Impairment.” 2014. Web. 17 Jan 2021.
Vancouver:
Rao S. Analysis of Practice Effects Across Cognitive Domains in Mild Cognitive Impairment. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2014. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/2152.5/1441.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Rao S. Analysis of Practice Effects Across Cognitive Domains in Mild Cognitive Impairment. [Thesis]. University of Texas Southwestern Medical Center; 2014. Available from: http://hdl.handle.net/2152.5/1441
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Toronto
11.
Hird, Megan Alexandra.
Investigating Simulated Driving Behaviour and Brain Activation in Mild Cognitive Impairment.
Degree: 2016, University of Toronto
URL: http://hdl.handle.net/1807/74890
► There are no guidelines or tools to help physicians assess the driving safety of patients with MCI. This study combined fMRI and driving simulation to…
(more)
▼ There are no guidelines or tools to help physicians assess the driving safety of patients with MCI. This study combined fMRI and driving simulation to compare the driving performance, and corresponding brain activation patterns, of patients with MCI and healthy controls. Patients with MCI committed significantly more driving errors compared to controls. Patients with amnestic multiple-domain MCI patients were at a greater risk of difficulty relative to those with amnestic single-domain MCI. Patients with MCI exhibited increased recruitment of frontal brain regions compared to controls, particularly during left turns with traffic. Patients with sd-MCI exhibited increased recruitment of frontal and medial regions across turning conditions, whereas patients with md-MCI exhibited decreased recruitment of frontal and medial regions. The results suggest that patients with MCI can demonstrate driving difficulties and deviations in brain activation compared to controls and that the areas and degree of difficulty vary across the subtypes of MCI.
M.Sc.
Advisors/Committee Members: Schweizer, Tom A, Medical Science.
Subjects/Keywords: driving; fMRI; mild cognitive impairment; simulation; 0317
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APA ·
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Export
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Manager
APA (6th Edition):
Hird, M. A. (2016). Investigating Simulated Driving Behaviour and Brain Activation in Mild Cognitive Impairment. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/74890
Chicago Manual of Style (16th Edition):
Hird, Megan Alexandra. “Investigating Simulated Driving Behaviour and Brain Activation in Mild Cognitive Impairment.” 2016. Masters Thesis, University of Toronto. Accessed January 17, 2021.
http://hdl.handle.net/1807/74890.
MLA Handbook (7th Edition):
Hird, Megan Alexandra. “Investigating Simulated Driving Behaviour and Brain Activation in Mild Cognitive Impairment.” 2016. Web. 17 Jan 2021.
Vancouver:
Hird MA. Investigating Simulated Driving Behaviour and Brain Activation in Mild Cognitive Impairment. [Internet] [Masters thesis]. University of Toronto; 2016. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/1807/74890.
Council of Science Editors:
Hird MA. Investigating Simulated Driving Behaviour and Brain Activation in Mild Cognitive Impairment. [Masters Thesis]. University of Toronto; 2016. Available from: http://hdl.handle.net/1807/74890
University of Texas Southwestern Medical Center
12.
Horton, Daniel Kevin.
Abbreviated and Expanded Forms of the Montreal Cognitive Assessment for Dementia Screening.
Degree: 2015, University of Texas Southwestern Medical Center
URL: http://hdl.handle.net/2152.5/1735
► Cognitive screening is becoming increasingly important as the general population ages and the prevalence of dementia rises. However, popular cognitive screening tools have been criticized…
(more)
▼ Cognitive screening is becoming increasingly important as the general population ages and the prevalence of dementia rises. However, popular
cognitive screening tools have been criticized for their insensitivity to subtle
cognitive impairment, poor specificity, excessive administration time, and/or questionable methods of test development. The Montreal
Cognitive Assessment (MoCA) is a
cognitive screening instrument growing in popularity which has demonstrated increased sensitivity to
mild cognitive impairment (MCI), but takes roughly 10-15 minutes to administer and was developed without an empirically-driven item selection process. We devised two studies to address common limitations of
cognitive screening tools using the MoCA. The aim of Study 1 was to create a short form of the MoCA (SF-MoCA) including only the items found to be most sensitive to MCI and Alzheimer disease (AD) and compare the diagnostic classification accuracy of the SF-MoCA to the Mini-Mental State Examination (MMSE) and standard MoCA. Results revealed delayed recall, orientation, and serial subtraction items to be most useful in differentiating the diagnostic groups. Overall, diagnostic accuracy of the SF-MoCA was superior to the MMSE and comparable to the standard MoCA, suggesting that some MoCA items do not add to the sensitivity of the instrument in these populations. Given the brevity and sensitivity of the SF-MoCA, we suggested this measure may be useful for early detection of
cognitive impairment in primary care and other settings where evaluation time is limited. Despite the advantages of the SF-MoCA, this tool only assesses three
cognitive domains and may not be appropriate in settings where clinicians may want to efficiently assess additional domains affected in AD and MCI to gain a clearer picture of global functioning and assist in differential diagnosis. Therefore, we conducted a second study to determine if diagnostic accuracy of the SF-MoCA might be enhanced through the addition of several brief and well-validated neuropsychological measures shown to be sensitive to
cognitive impairment. Results revealed that the addition of measures of processing speed, category fluency, and verbal recall resulted in an Expanded SF-MoCA with diagnostic classification accuracy superior to both the standard MoCA and SF-MoCA. Findings of these studies have implications for current
cognitive screening procedures and techniques used to develop these tools.
Advisors/Committee Members: Cullum, C. Munro, Hynan, Linda S., Lacritz, Laura H., Rossetti, Heidi, Weiner, Myron F..
Subjects/Keywords: Dementia; Mild Cognitive Impairment; Neuropsychological Tests
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APA ·
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CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Horton, D. K. (2015). Abbreviated and Expanded Forms of the Montreal Cognitive Assessment for Dementia Screening. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/1735
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Horton, Daniel Kevin. “Abbreviated and Expanded Forms of the Montreal Cognitive Assessment for Dementia Screening.” 2015. Thesis, University of Texas Southwestern Medical Center. Accessed January 17, 2021.
http://hdl.handle.net/2152.5/1735.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Horton, Daniel Kevin. “Abbreviated and Expanded Forms of the Montreal Cognitive Assessment for Dementia Screening.” 2015. Web. 17 Jan 2021.
Vancouver:
Horton DK. Abbreviated and Expanded Forms of the Montreal Cognitive Assessment for Dementia Screening. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2015. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/2152.5/1735.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Horton DK. Abbreviated and Expanded Forms of the Montreal Cognitive Assessment for Dementia Screening. [Thesis]. University of Texas Southwestern Medical Center; 2015. Available from: http://hdl.handle.net/2152.5/1735
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Texas Southwestern Medical Center
13.
Ritter, Ashley Reyes.
Use of Cognitive Screening and the Influence of Psychosocial Variables in Identification of Cognitive Impairment in MS.
Degree: 2013, University of Texas Southwestern Medical Center
URL: http://hdl.handle.net/2152.5/1310
► BACKGROUND: The purpose of this project is to examine the potential of abbreviated cognitive screening to identify patients with clinically significant cognitive dysfunction. A secondary…
(more)
▼ BACKGROUND: The purpose of this project is to examine the potential of abbreviated
cognitive screening to identify patients with clinically significant
cognitive dysfunction. A secondary goal is to examine relationships between
cognitive functioning and psychosocial factors of disease.
SUBJECTS: The study includes 94 subjects with a Demyelinating disease [M age = 45.04 (11.08); M education = 15.40 (2.13)] who were referred to the University of Texas Southwestern Medical Multiple Sclerosis Clinical Center and Multiple Sclerosis Program and signed informed consent for a larger study on cognition in multiple sclerosis and demyelinating disease.
METHOD: Subjects completed a screening battery (JoL, 9HPT, PASAT, SDMT-Oral, and T25FW) at visit one and a larger
cognitive assessment within 4 weeks of visit one, which was used to divide subjects into impaired and non-impaired groups. Linear regression was used to assess which tests on the screening battery predicted
impairment on the longer battery. Associations between psychosocial factors of depression, fatigue, and sleepiness were examined in relation to
cognitive performance. The relationship between depression and objective versus subjective
cognitive performance was also examined.
RESULTS: The PASAT (p = .001) was the only measure in the screening battery that predicted group membership, with correct classification of 76% of subjects using a cut score of T ² 38. Depression (QIDS-SR) was significantly correlated with self-reported
cognitive dysfunction (MSNQ) (r = .57; p = <.001) but only modestly associated with the four measures on the screening battery (r = -.17 to .25). Those who endorsed depressive symptoms performed lower on JoL(p = .003), PASAT (p = .015) and SDMT (p = .023). Level of fatigue was associated with
cognitive performance, as significant mean differences were found on all screening battery measures in high versus low fatigue groups. There was no impact of sleepiness on cognition.
DISCUSSION: Complex attention was the most sensitive measure for predicting
cognitive impairment on a more comprehensive battery and may be a good screening tool in identifying who might benefit from more detailed testing. Higher levels of depression and fatigue significantly impacted test performance and highlight important areas for screening and treatment, while daytime sleepiness had no effect.
Advisors/Committee Members: Lacritz, Laura H., Hynan, Linda S., Cullum, C. Munro.
Subjects/Keywords: Multiple Sclerosis; Mild Cognitive Impairment; Psychological Tests
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APA ·
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Export
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APA (6th Edition):
Ritter, A. R. (2013). Use of Cognitive Screening and the Influence of Psychosocial Variables in Identification of Cognitive Impairment in MS. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/1310
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Ritter, Ashley Reyes. “Use of Cognitive Screening and the Influence of Psychosocial Variables in Identification of Cognitive Impairment in MS.” 2013. Thesis, University of Texas Southwestern Medical Center. Accessed January 17, 2021.
http://hdl.handle.net/2152.5/1310.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Ritter, Ashley Reyes. “Use of Cognitive Screening and the Influence of Psychosocial Variables in Identification of Cognitive Impairment in MS.” 2013. Web. 17 Jan 2021.
Vancouver:
Ritter AR. Use of Cognitive Screening and the Influence of Psychosocial Variables in Identification of Cognitive Impairment in MS. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2013. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/2152.5/1310.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Ritter AR. Use of Cognitive Screening and the Influence of Psychosocial Variables in Identification of Cognitive Impairment in MS. [Thesis]. University of Texas Southwestern Medical Center; 2013. Available from: http://hdl.handle.net/2152.5/1310
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Univerzitet u Beogradu
14.
Maćešić, Marija, 1978-.
Analiza uticaja insulinske rezistencije i metaboličkih
determinanti na kognitivnu disfunkciju u blagom kognitivnom
poremećaju i Alchajmerovoj bolesti.
Degree: Medicinski fakultet, 2017, Univerzitet u Beogradu
URL: https://fedorabg.bg.ac.rs/fedora/get/o:14648/bdef:Content/get
► medicina - endokrinologija / medicine - endocrinology
Uvod: Prethodne studije su ukazale na moguću ulogu snižene insulinske senzitivnosti i sekrecije u patogenezi Alchajmerove bolesti (AB)…
(more)
▼ medicina - endokrinologija / medicine -
endocrinology
Uvod: Prethodne studije su ukazale na moguću ulogu
snižene insulinske senzitivnosti i sekrecije u patogenezi
Alchajmerove bolesti (AB) i blagog kognitivnog poremećaja (BKP),
prelaznog stanja između normalnog procesa starenja i AB. Međutim,
složeni mehanizmi kojima poremećaji insulinske senzitivnosti mogu
ostvarivati svoj uticaj u nastanku kognitivne disfunkcije još uvek
nisu do kraja proučeni. Cilj:Cilj rada je ispitivanje povezanosti
insulinske rezistencije (IR) i metaboličkih parametara i
ispoljavanja kognitivne disfunkcije u BKP i AB. Metode: U
ispitivanje je uključeno 62 ispitanika sa AB (grupa A), 41
ispitanika sa BKP (grupa B) i 40 zdravih ispitanika (grupa C). U
svakog bolesnika je evaluirano stanje insulinske senzitivnosti
metodom hiperinsulinemijskog euglikemijskog klampa i metodom modela
homeostaze, kapacitet rane faze insulinske sekrecije metodom
intravenskog testa tolerancije glukoze (FPIR i AIR), nivo insulina
u serumu RIA metodom, adiponektina ELISA metodom, lipidni
parametri, ukupni holesterol (h), HDL-h, LDL-h, trigliceridi
metodom hromatografije, apolipoproteini ApoAI, ApoAII, ApoB, Lp(a),
ApoE metodom nefelometrije. Rezultati: Evaluacijom stanja
insulinske senzitivnosti primenom obe metode je pokazan značajno
viši nivo insulinske rezistencije (IR) u grupi A u odnosu na grupu
B i C, (M vrednost: A:6.22+/-0.31; B: 7.70+/-0.42; C:8.25+/-0.24
mg/min/kg, p<0.001); (HOMA-IR: A:4.59+/-0.28; B:3.35+/-0.27;
C:1.49+/-0.15, p<0.001). Istovremeno, oba parametra kapaciteta
rane faze insulinske sekrecije, AIR i FPIR su bila značajno niža u
grupi A u odnosu na grupu B i C (AIR: A:26.49+/-2.02;
B:49.54+/-6.26; C:72.05+/-3.68 mU/l); (FPIR: A:68.90+/-3.53;
B:112.51+/-7.36; C:147.43+/-8.86 mU/l, p<0.001). Bazalna
insulinemija je bila značajno viša u grupi A u odnosu na grupe B i
C (A:18.08+/-1.54; B:13.77+/-1.08; C:7.18+/-0.68 mU/l, p<0.01).
Nivo adiponektina u serumu je bio niži u grupu A vs B vs C
(A:14.91+/-0.42; B:16.99+/-0.91; C:18.63+/-0.58 ng/m, A vs B and A
vs C p<0.01, B vs C p< 0.05), dok je nivo ukupnog h, LDL-h,
ApoB and Lp(a) bio značajno niži, a HDL-h I ApoAI unačajno niži u
grupi A i B vs C. Nivo triglicerida i ApoAII se nije značajno
razlikovao među grupama. Binarnom logističkom regresijom je uočena
značajan uticaj M vrednosti, insulinemije našte i FPIR sa
ispoljavanjem BKP i AD (p=0.006, p=0.06, p=0.01, respektivno).
Zaključak: Naši rezultati ukazuju da u bolesnika sa AB i BKP, IR sa
sniženim kapacitetom insulinske sekrecije ostvaruje snažan uticaj
na ispoljavanje AB i BKP, sa manjim uticajem sniženog nivoa
adiponektina i aterogenim lipidnim profilom.
Advisors/Committee Members: Lalić, Nebojša M., 1958-.
Subjects/Keywords: insulin resistance; mild cognitive impairment;
Alcheimer’s disease
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Manager
APA (6th Edition):
Maćešić, Marija, 1. (2017). Analiza uticaja insulinske rezistencije i metaboličkih
determinanti na kognitivnu disfunkciju u blagom kognitivnom
poremećaju i Alchajmerovoj bolesti. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:14648/bdef:Content/get
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Maćešić, Marija, 1978-. “Analiza uticaja insulinske rezistencije i metaboličkih
determinanti na kognitivnu disfunkciju u blagom kognitivnom
poremećaju i Alchajmerovoj bolesti.” 2017. Thesis, Univerzitet u Beogradu. Accessed January 17, 2021.
https://fedorabg.bg.ac.rs/fedora/get/o:14648/bdef:Content/get.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Maćešić, Marija, 1978-. “Analiza uticaja insulinske rezistencije i metaboličkih
determinanti na kognitivnu disfunkciju u blagom kognitivnom
poremećaju i Alchajmerovoj bolesti.” 2017. Web. 17 Jan 2021.
Vancouver:
Maćešić, Marija 1. Analiza uticaja insulinske rezistencije i metaboličkih
determinanti na kognitivnu disfunkciju u blagom kognitivnom
poremećaju i Alchajmerovoj bolesti. [Internet] [Thesis]. Univerzitet u Beogradu; 2017. [cited 2021 Jan 17].
Available from: https://fedorabg.bg.ac.rs/fedora/get/o:14648/bdef:Content/get.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Maćešić, Marija 1. Analiza uticaja insulinske rezistencije i metaboličkih
determinanti na kognitivnu disfunkciju u blagom kognitivnom
poremećaju i Alchajmerovoj bolesti. [Thesis]. Univerzitet u Beogradu; 2017. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:14648/bdef:Content/get
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Illinois – Chicago
15.
Goyal, Nikita.
Role of mild cognitive impairment in postural control of older adults.
Degree: 2018, University of Illinois – Chicago
URL: http://hdl.handle.net/10027/23116
► This thesis primarily focuses on studying the effects of dual tasks on the postural control in older adults with Mild Cognitive Impairment (MCI). The study…
(more)
▼ This thesis primarily focuses on studying the effects of dual tasks on the postural control in older adults with
Mild Cognitive Impairment (MCI). The study tries to answer the following questions: Is there any difference in postural control between individuals with MCI and older adults? Will there be any difference in performance of a secondary task in individuals with MCI to that of older adults without impaired cognition? Will the dual task effect the postural control in the individuals with MCI? Will the complexity of the dual task affect postural control in individuals with MCI to a larger degree compared to healthy older adults?
The first chapter of the thesis provides information about the present statistics on population at falls risk. It then provides information about
Mild Cognitive Impairment (MCI) and describes the neuropathology basis of MCI as what changes occurs within the MCI and its progression. The chapter also introduces information related to the importance of study of postural balance in MCI and older adults and describes the previous research methods to study postural control. Than a statement of aims of the study is provided. Then information is provided about how participants were chosen for the study, the inclusion and exclusion criteria, IRB (International Review Board) approval obtained for the study, and the clinical assessment measures performed within the study to provide descriptive information about the study participants.
The second chapter describes the results of the study of the effect of a
cognitive task and light finger touch on standing balance in healthy adults. As previous studies have reported the individual effects of
cognitive task and light finger touch, this study is the first to determine the concurrent effect of the
cognitive task and finger touch on static balance in young healthy adults. This study involving healthy individuals provides a foundation for the study of the effect of a
cognitive task and finger touch in balance control of older adults and individuals with
cognitive impairment.
The third chapter includes 3 studies investigating dual task effect on static and dynamic balance in individuals with MCI as compared to healthy older adults. Part 1 of the third chapter is in line with the second chapter involving investigation of the concurrent effect of
cognitive task and light finger touch on standing balance in the individuals with MCI as compared to older adults. Part 2 of the third chapter focuses on the study of the effect of manual and
cognitive secondary task on spatio-temporal gait variables in older adults with
Mild Cognitive Impairment. Gait variables reported were gait velocity, cadence, step length and stride length that provides definite measures of gait cycle. Part 3 is devoted to the study of the effect of dual task on performance of clinical test of mobility and balance. In particular, we investigated how individuals with MCI perform Timed Up and Go (TUG) test in 3 experimental conditions involving concurrent secondary task performance. The TUG…
Advisors/Committee Members: Aruin, Alexander S (advisor), Luna, Geraldine (committee member), Girolami, Gay l (committee member), Aruin, Alexander S (chair).
Subjects/Keywords: Mild Cognitive Impairment; Postural control; MCI
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APA (6th Edition):
Goyal, N. (2018). Role of mild cognitive impairment in postural control of older adults. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/23116
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Goyal, Nikita. “Role of mild cognitive impairment in postural control of older adults.” 2018. Thesis, University of Illinois – Chicago. Accessed January 17, 2021.
http://hdl.handle.net/10027/23116.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Goyal, Nikita. “Role of mild cognitive impairment in postural control of older adults.” 2018. Web. 17 Jan 2021.
Vancouver:
Goyal N. Role of mild cognitive impairment in postural control of older adults. [Internet] [Thesis]. University of Illinois – Chicago; 2018. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/10027/23116.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Goyal N. Role of mild cognitive impairment in postural control of older adults. [Thesis]. University of Illinois – Chicago; 2018. Available from: http://hdl.handle.net/10027/23116
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Minnesota
16.
George, Kristen.
Dementia and Mild Cognitive Impairment: Epidemiologic Research of Risk Factors.
Degree: PhD, Epidemiology, 2019, University of Minnesota
URL: http://hdl.handle.net/11299/206665
► Dementia and mild cognitive impairment (MCI) are often caused by progressive and irreversible pathologic brain changes. Alzheimer’s disease, cerebrovascular disease, and Lewy body-related diseases are…
(more)
▼ Dementia and mild cognitive impairment (MCI) are often caused by progressive and irreversible pathologic brain changes. Alzheimer’s disease, cerebrovascular disease, and Lewy body-related diseases are the most common causes with many individuals having mixed etiologies. Characterizing risk factors for dementia and MCI is complex due to overlapping etiologies, long latency periods, and the influence of cognitive reserve. While major risk factors including advanced age, hypertension, and the ApoE4 allele have been identified, further investigation of early- and mid-life risk factors is needed. Using data from the Atherosclerosis Risk in Communities (ARIC) Neurocognitive Study, we examined prospectively risk factors for dementia and MCI. In the first manuscript, we assessed the association between life course socioeconomic status (LC-SES) and dementia and MCI. Low individual-level LC-SES was associated with an increased risk of dementia. Low individual-level economic factors of LC-SES (e.g. income, home ownership) were associated with increased risk of dementia independent of educational attainment. However, neighborhood-level LC-SES was not associated with risk of dementia or MCI. The second manuscript assessed the association between thyroid dysfunction (measured via autoimmune thyroid disease (AITD) and thyroid hormone levels) and risk of dementia and MCI. We found no association between AITD and dementia and MCI. Subclinical hypothyroidism was associated with a lower risk of dementia while overt hyperthyroidism, particularly with very elevated serum FT4 hormone levels, was associated with an increased risk of dementia compared to euthyroid participants. The third manuscript examined the association between lifetime history of migraine symptoms and risk of dementia and MCI. Despite published evidence of brain abnormalities in migraineurs, which might lead to cognitive impairment, we found no association between migraine and dementia and MCI. This dissertation extends our understanding of risk factors for cognitive impairment underscoring the importance of early- and mid-life exposures on late-life risk of dementia and MCI.
Subjects/Keywords: Cohort; Dementia; Mild Cognitive Impairment; Risk Factors
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APA (6th Edition):
George, K. (2019). Dementia and Mild Cognitive Impairment: Epidemiologic Research of Risk Factors. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/206665
Chicago Manual of Style (16th Edition):
George, Kristen. “Dementia and Mild Cognitive Impairment: Epidemiologic Research of Risk Factors.” 2019. Doctoral Dissertation, University of Minnesota. Accessed January 17, 2021.
http://hdl.handle.net/11299/206665.
MLA Handbook (7th Edition):
George, Kristen. “Dementia and Mild Cognitive Impairment: Epidemiologic Research of Risk Factors.” 2019. Web. 17 Jan 2021.
Vancouver:
George K. Dementia and Mild Cognitive Impairment: Epidemiologic Research of Risk Factors. [Internet] [Doctoral dissertation]. University of Minnesota; 2019. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/11299/206665.
Council of Science Editors:
George K. Dementia and Mild Cognitive Impairment: Epidemiologic Research of Risk Factors. [Doctoral Dissertation]. University of Minnesota; 2019. Available from: http://hdl.handle.net/11299/206665
California State University – Northridge
17.
Flowers, Amina.
Functional deficits in Mild Cognitive Impairment and Alzheimer's Disease.
Degree: MA, Department of Psychology, 2015, California State University – Northridge
URL: http://hdl.handle.net/10211.3/141675
► Alzheimer???s disease (AD) is a chronic neurocognitive degenerative disease affecting millions of individuals every day. Mild Cognitive Impairment (MCI) represents a prodromal gray-area state between…
(more)
▼ Alzheimer???s disease (AD) is a chronic neurocognitive degenerative disease affecting millions of individuals every day.
Mild Cognitive Impairment (MCI) represents a prodromal gray-area state between normal aging and
cognitive impairment. MCI is frequently a precursor to several forms of neurocognitive deficits, most commonly Alzheimer???s disease. Research suggests that early detection of the inability to carry out activities of daily living (ADL) may aid in identifying those at greatest risk for additional decline. Nonetheless, the severity of ADL functioning in MCI and
mild stages of AD remains unclear. The purpose of this study was to characterize
impairment in various domains of ADL functioning in MCI relative to AD and normal elderly controls. Participants were recruited from various medical and health centers in the greater Los Angeles area. The sample consisted of 59 AD patients, 38 MCI patients, and 64 normal controls. All participants were administered the Direct Assessment of Functional Status (DAFS), and the following 5 domains will be analyzed: 1) time orientation (Orientation); 2) communication abilities (Communication); 3) transportation knowledge (Transportation); 4) financial skills (Financial); and 5) shopping skills (Shopping). A multivariate analysis of variance was conducted to characterize and assess differences among groups. Results revealed significant differences among all three groups on DAFS overall performance. Post hoc analysis revealed that normal controls performed best, followed by MCI, and then the AD group on most of the DAFS subscales. This information can provide an understanding of the course of functional change and hopefully support the imperative need for the development of methods for treatment plans in functional deficits.
Advisors/Committee Members: Razani, Laleh J (advisor), Mitrushina, Maura N (committee member).
Subjects/Keywords: Mild Cognitive Impairment; Dissertations, Academic – CSUN – Psychology.
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APA ·
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APA (6th Edition):
Flowers, A. (2015). Functional deficits in Mild Cognitive Impairment and Alzheimer's Disease. (Masters Thesis). California State University – Northridge. Retrieved from http://hdl.handle.net/10211.3/141675
Chicago Manual of Style (16th Edition):
Flowers, Amina. “Functional deficits in Mild Cognitive Impairment and Alzheimer's Disease.” 2015. Masters Thesis, California State University – Northridge. Accessed January 17, 2021.
http://hdl.handle.net/10211.3/141675.
MLA Handbook (7th Edition):
Flowers, Amina. “Functional deficits in Mild Cognitive Impairment and Alzheimer's Disease.” 2015. Web. 17 Jan 2021.
Vancouver:
Flowers A. Functional deficits in Mild Cognitive Impairment and Alzheimer's Disease. [Internet] [Masters thesis]. California State University – Northridge; 2015. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/10211.3/141675.
Council of Science Editors:
Flowers A. Functional deficits in Mild Cognitive Impairment and Alzheimer's Disease. [Masters Thesis]. California State University – Northridge; 2015. Available from: http://hdl.handle.net/10211.3/141675
University of Canterbury
18.
Jones, Ann Judith.
Parkinson's Disease, Cognitive Status and Caregiver Outcomes.
Degree: MA, Psychology, 2013, University of Canterbury
URL: http://dx.doi.org/10.26021/5095
► Cognitive impairment in Parkinson’s disease (PD) can impact negatively on caregivers and is associated with carer distress and feelings of burden. To investigate this relationship…
(more)
▼ Cognitive impairment in Parkinson’s disease (PD) can impact negatively on caregivers and is associated with carer distress and feelings of burden. To investigate this relationship we examined level of burden, coping strategies, depression, anxiety and potential positive aspects of caregiving in the caregivers of 104 PD patients. The PD patients were classified as either showing normal cognition (PD-N; n=57), with mild cognitive impairment (PD-MCI; n=31) or with dementia (PD-D; n=16). The key finding was that mean Zarit burden score increased between carers of PD-N (M=14.1, SD=12.0) through to PD-MCI (M=21.1, SD=9.86) and PD-D (M=27.8, SD=10.61); F (2,101) =9.96, p<0.001. Post hoc tests (Newman-Keuls) identified significantly higher Zarit burden scores in PD-D caregivers compared to both PD-N (p<.001) and PD-MCI patients (p<.05), but carers of PD-MCI patients also showed increased burden scores relative to those of PD-N patients (p<.05). The proportion of carers showing significant levels of burden (Zarit burden score ≥21) also increased as cognition declined (21% for PD-N; 58% for PD-MCI; and 81% for PD-D). Time spent providing care and problem-focused, emotion-focused and dysfunctional coping strategies also increased with worsening cognition. While caregiver use of problem-focused coping mediated the association between patient cognitive status and caregiver burden, we could not be confident about this relationship as the inverse model was also significant. Caregiver Zarit burden was independent of caregiver depression, anxiety and positive attributions of caregiving. The study highlights the impact of Parkinson’s disease on those providing care when the patients’ cognition is poor, including those with MCI. Caregiver well-being has important implications for nursing home placement and disease course.
Subjects/Keywords: Parkinson's disease; mild cognitive impairment; caregiver burden
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APA (6th Edition):
Jones, A. J. (2013). Parkinson's Disease, Cognitive Status and Caregiver Outcomes. (Masters Thesis). University of Canterbury. Retrieved from http://dx.doi.org/10.26021/5095
Chicago Manual of Style (16th Edition):
Jones, Ann Judith. “Parkinson's Disease, Cognitive Status and Caregiver Outcomes.” 2013. Masters Thesis, University of Canterbury. Accessed January 17, 2021.
http://dx.doi.org/10.26021/5095.
MLA Handbook (7th Edition):
Jones, Ann Judith. “Parkinson's Disease, Cognitive Status and Caregiver Outcomes.” 2013. Web. 17 Jan 2021.
Vancouver:
Jones AJ. Parkinson's Disease, Cognitive Status and Caregiver Outcomes. [Internet] [Masters thesis]. University of Canterbury; 2013. [cited 2021 Jan 17].
Available from: http://dx.doi.org/10.26021/5095.
Council of Science Editors:
Jones AJ. Parkinson's Disease, Cognitive Status and Caregiver Outcomes. [Masters Thesis]. University of Canterbury; 2013. Available from: http://dx.doi.org/10.26021/5095
University of Sydney
19.
Jayaweera, Hirosha Keshani.
Delineating neural substrates of learning and memory impairments in older adults with depressive symptoms
.
Degree: 2016, University of Sydney
URL: http://hdl.handle.net/2123/16734
► Depression occurring in older people is often associated with cognitive impairment, underlying brain changes, treatment resistance and disability. Impairments in the domain of learning and…
(more)
▼ Depression occurring in older people is often associated with cognitive impairment, underlying brain changes, treatment resistance and disability. Impairments in the domain of learning and memory are particularly problematic as these tend persist despite depression symptom resolution. Furthermore, learning and memory impairments have been directly linked to hippocampal atrophy, which in turn has been associated with ongoing cognitive decline and dementia, longitudinally. However, the relationship between depression in older age, and learning/memory impairments, as well as underlying processes contributing to these deficits remains unclear. Contained within this thesis are a series of three published studies. Each examines learning and memory impairments in a clinical sample aged over 50 years whom have a lifetime diagnosis of major depression. The studies examine learning and memory performance with respect to hippocampal size, and its role in Mild Cognitive Impairment, in-vivo neurochemical markers of hippocampal neuronal integrity, and the anterior caudate nucleus, a subcortical structure that has been previously identified as being linked to clinical outcomes, and pathophysiology. The findings of these empirical studies thesis demonstrates the critical link between both hippocampal and caudate nucleus integrity and their role in specifically mediating memory performance, and have important implications for pathophysiology and early intervention models.
Subjects/Keywords: depression;
cognition;
hippocampus;
mild-cognitive impairment
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APA (6th Edition):
Jayaweera, H. K. (2016). Delineating neural substrates of learning and memory impairments in older adults with depressive symptoms
. (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/16734
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Jayaweera, Hirosha Keshani. “Delineating neural substrates of learning and memory impairments in older adults with depressive symptoms
.” 2016. Thesis, University of Sydney. Accessed January 17, 2021.
http://hdl.handle.net/2123/16734.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Jayaweera, Hirosha Keshani. “Delineating neural substrates of learning and memory impairments in older adults with depressive symptoms
.” 2016. Web. 17 Jan 2021.
Vancouver:
Jayaweera HK. Delineating neural substrates of learning and memory impairments in older adults with depressive symptoms
. [Internet] [Thesis]. University of Sydney; 2016. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/2123/16734.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Jayaweera HK. Delineating neural substrates of learning and memory impairments in older adults with depressive symptoms
. [Thesis]. University of Sydney; 2016. Available from: http://hdl.handle.net/2123/16734
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of New South Wales
20.
Gates, Nicola.
Psychological wellbeing and quality of life in mild cognitive impairment.
Degree: Psychiatry, 2013, University of New South Wales
URL: http://handle.unsw.edu.au/1959.4/52984
;
https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11662/SOURCE01?view=true
► A rising interest in Quality of Life (QoL) research has occurred in the context of increasing numbers of older adults, projections of dementia prevalence, policy…
(more)
▼ A rising interest in Quality of Life (QoL) research has occurred in the context of increasing numbers of older adults, projections of dementia prevalence, policy interest to reduce health expenditure, and the desire for positive ageing. Coupled with this has been the advancement of early interventions as a means to preserve independence, improve cognition and promote QoL. Evidence from epidemiological studies and clinical trials suggests that the introduction of
cognitive and physical interventions in adults with
mild cognitive impairment (MCI) may improve cognition. However, to date there has been limited investigation of QoL and psychological wellbeing (PWB) outcomes in these studies. The objective of this thesis was therefore to investigate PWB and QoL in adults with MCI. This research is based upon published literature as well as data from the Study of Mental Activity and Regular Training (SMART) Trial, a randomised
cognitive and resistance training trial on 100 community-dwelling adults with MCI. Four investigations were performed. Firstly, meta-analyses of QoL and PWB outcomes from randomised controlled trials of physical exercise and
cognitive training in MCI indicated limited benefit for QoL and PWB outcomes. Secondly, empirical analyses of a theoretical model of PWB, using cross sectional baseline data from the SMART trial, predicted 61% of the variance of PWB in MCI. Memory concern and
cognitive deficits were identified as significant predictors of PWB, along with negative affect and QoL. Thirdly, linear mixed model analyses of SMART physical and
cognitive intervention found that mental health-related QoL and Purpose in Life subscale within PWB domain improved following combined intervention. By contrast, isolated
cognitive or physical interventions had no significant benefit on any component of QoL or PWB. Lastly, regression analyses indicated that improvement in
cognitive function after the interventions was not associated with a reduction in memory concern or improvement in QoL or PWB. Overall, this thesis demonstrated that QoL and PWB in MCI have multiple influences, and that interventions designed to improve cognition do not necessarily improve PWB. Clinical implications from this research are discussed in terms of the development of early intervention programmes in MCI and future research studies.
Advisors/Committee Members: Valenzuela, Michael, The University of Sydney, Sachdev, Perminder, Faculty of Medicine, UNSW, Fiatarone-Singh, Maria, The University of Sydney.
Subjects/Keywords: Mild Cognitive Impairment; Quality of life; Wellbeing
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APA ·
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Manager
APA (6th Edition):
Gates, N. (2013). Psychological wellbeing and quality of life in mild cognitive impairment. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/52984 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11662/SOURCE01?view=true
Chicago Manual of Style (16th Edition):
Gates, Nicola. “Psychological wellbeing and quality of life in mild cognitive impairment.” 2013. Doctoral Dissertation, University of New South Wales. Accessed January 17, 2021.
http://handle.unsw.edu.au/1959.4/52984 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11662/SOURCE01?view=true.
MLA Handbook (7th Edition):
Gates, Nicola. “Psychological wellbeing and quality of life in mild cognitive impairment.” 2013. Web. 17 Jan 2021.
Vancouver:
Gates N. Psychological wellbeing and quality of life in mild cognitive impairment. [Internet] [Doctoral dissertation]. University of New South Wales; 2013. [cited 2021 Jan 17].
Available from: http://handle.unsw.edu.au/1959.4/52984 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11662/SOURCE01?view=true.
Council of Science Editors:
Gates N. Psychological wellbeing and quality of life in mild cognitive impairment. [Doctoral Dissertation]. University of New South Wales; 2013. Available from: http://handle.unsw.edu.au/1959.4/52984 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11662/SOURCE01?view=true
Virginia Tech
21.
Pasymowski, Stefan G.
Expressed Emotion in Families with Mild Cognitive Impairment.
Degree: PhD, Human Development, 2015, Virginia Tech
URL: http://hdl.handle.net/10919/73872
► Mild cognitive impairment (MCI) is a medical diagnosis that is conceptualized as existing on a continuum between normal cognitive aging and dementia. While a growing…
(more)
▼ Mild cognitive impairment (MCI) is a medical diagnosis that is conceptualized as existing on a continuum between normal
cognitive aging and dementia. While a growing body of research has established the impact of this condition on family members' emotional well-being, as well as the quality of family relationships, the reciprocal impact of family dynamics and the family environment on illness course has received much less attention. Expressed emotion (EE) is a measure of the family emotional climate that has been established as being highly predictive of relapse and symptom exacerbation for a variety of mental health disorders. The recent integration of attribution theory with EE has offered new insights into the underlying attitudes and beliefs that give rise to it. This mixed methods study applied the attribution model of EE to test the validity of EE in predicting the illness course of MCI, and to identify family members' attributions regarding MCI-related behaviors and symptoms that underlie their EE status. The study sample included 57 family dyads consisting of a person with MCI and a family member providing primary care or assistance. The results of the ANCOVA did not support the hypothesis that EE status would predict changes in the non-
cognitive features of MCI over time. However, methods of thematic analysis revealed four major themes, or care partner attributional stances: (a) non-blaming, (b) blaming, (c) variable, and (d) no identified. The analysis also revealed three subthemes, or attributional styles, within the variable stance: (a) ambivalent, (b) mixed, and (c) complex. These attributional stances and styles intersected with family EE status in notable ways and form the basis for future research in this area, as well as clinical interventions with these families that promote adaptation to the illness.
Advisors/Committee Members: Dolbin-MacNab, Megan L. (committeechair), Blieszner, Rosemary (committee member), Piercy, Fred P. (committee member), Roberto, Karen A. (committee member).
Subjects/Keywords: mild cognitive impairment; expressed emotion; attribution theory
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APA ·
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Export
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Manager
APA (6th Edition):
Pasymowski, S. G. (2015). Expressed Emotion in Families with Mild Cognitive Impairment. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/73872
Chicago Manual of Style (16th Edition):
Pasymowski, Stefan G. “Expressed Emotion in Families with Mild Cognitive Impairment.” 2015. Doctoral Dissertation, Virginia Tech. Accessed January 17, 2021.
http://hdl.handle.net/10919/73872.
MLA Handbook (7th Edition):
Pasymowski, Stefan G. “Expressed Emotion in Families with Mild Cognitive Impairment.” 2015. Web. 17 Jan 2021.
Vancouver:
Pasymowski SG. Expressed Emotion in Families with Mild Cognitive Impairment. [Internet] [Doctoral dissertation]. Virginia Tech; 2015. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/10919/73872.
Council of Science Editors:
Pasymowski SG. Expressed Emotion in Families with Mild Cognitive Impairment. [Doctoral Dissertation]. Virginia Tech; 2015. Available from: http://hdl.handle.net/10919/73872
University of New South Wales
22.
Song, Fei.
Plasma biomarkers of mild cognitive impairment and Alzheimer’s disease.
Degree: Psychiatry, 2011, University of New South Wales
URL: http://handle.unsw.edu.au/1959.4/51518
;
https://unsworks.unsw.edu.au/fapi/datastream/unsworks:10205/SOURCE02?view=true
► Purpose: With the move towards development of disease modifying treatments, there is a need for a more specific early diagnosis of mild cognitive impairment (MCI)…
(more)
▼ Purpose: With the move towards development of disease modifying treatments, there is a need for a more specific early diagnosis of
mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Plasma biomarkers are likely to play an important role in this. This thesis comprises a series of studies to examine established and novel plasma biomarkers of
cognitive disorders, in particular MCI and AD, and their progression. Methods: A meta-analysis was undertaken to evaluate whether plasma amyloid beta (Aβ) levels are an appropriate biomarker in cross-sectional and longitudinal studies of AD. A proteomics approach was then used to screen for MCI and AD protein biomarkers in pooled plasma in a cohort of 280 MCI, 19 AD and 411 cognitively normal subjects. Based on the proteomics data, multiplex bead immunoassay techniques were used to validate targeted protein biomarkers in individual samples. Results: Meta-analysis results showed that in longitudinal studies cognitively normal individuals who converted to AD had higher baseline Aβ1-40 and Aβ1-42 levels, and a non-significantly increased Aβ1-42/ Aβ1-40 ratio. Systematic review suggests a model of differential longitudinal changes in plasma Aβ levels in cognitively stable individuals versus those who go on to develop AD dementia. A proteomics study using isobaric tags for relative and absolute quantitation (iTRAQ) showed 30 proteins significantly dysregulated in MCI and AD, including ApoA1, ApoA2, ApoB100, ApoH, ApoJ (clusterin), vitamin D binding protein (VDBP), Ig mu chain C region (IGHM) and afamin. Western blot results confirmed iTRAQ results: IGHM was increased and afamin was decreased in the MCI and AD groups. A group of seven apolipoproteins, β2 microglobulin, haptoglobin, C-reactive protein and VDBP were assayed by multiplex assays. Lower ApoA1, ApoA2 and ApoH levels, and a higher ApoB/ApoA1 ratio, increased the risk of
cognitive decline over two years in cognitively normal individuals. ApoA1 was the most significant predictor of decline. These associations remained after statistically controlling for the lipid profile. Higher ApoJ levels predicted white matter atrophy over two years. VDBP was associated with
cognitive decline in female patients. Conclusion: Plasma Aβ1-40 and Aβ1-42 levels should be further explored as potential biomarkers. Proteomic approaches are promising techniques for screening for biomarkers. Although these findings need to be validated in different populations, they suggest that ApoA1, ApoH, ApoJ and VDBP can be considered as clinical biomarkers for
cognitive impairment. Dysregulation of these proteins provides new clues to the possible pathogenesis of AD.
Advisors/Committee Members: Sachdev, Perminder, Psychiatry, Faculty of Medicine, UNSW, Poljak, Anne, Medical Sciences, Faculty of Medicine, UNSW, Smythe, George, Medical Sciences, Faculty of Medicine, UNSW.
Subjects/Keywords: Alzheimer's disease; Plasma biomarkers; Mild Cognitive Impairment
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APA (6th Edition):
Song, F. (2011). Plasma biomarkers of mild cognitive impairment and Alzheimer’s disease. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/51518 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:10205/SOURCE02?view=true
Chicago Manual of Style (16th Edition):
Song, Fei. “Plasma biomarkers of mild cognitive impairment and Alzheimer’s disease.” 2011. Doctoral Dissertation, University of New South Wales. Accessed January 17, 2021.
http://handle.unsw.edu.au/1959.4/51518 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:10205/SOURCE02?view=true.
MLA Handbook (7th Edition):
Song, Fei. “Plasma biomarkers of mild cognitive impairment and Alzheimer’s disease.” 2011. Web. 17 Jan 2021.
Vancouver:
Song F. Plasma biomarkers of mild cognitive impairment and Alzheimer’s disease. [Internet] [Doctoral dissertation]. University of New South Wales; 2011. [cited 2021 Jan 17].
Available from: http://handle.unsw.edu.au/1959.4/51518 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:10205/SOURCE02?view=true.
Council of Science Editors:
Song F. Plasma biomarkers of mild cognitive impairment and Alzheimer’s disease. [Doctoral Dissertation]. University of New South Wales; 2011. Available from: http://handle.unsw.edu.au/1959.4/51518 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:10205/SOURCE02?view=true
Boston University
23.
Murati, Anastasia.
The automatic segmentation of the human amygdala in amnestic mild cognitive impairment.
Degree: MS, Anatomy & Neurobiology, 2020, Boston University
URL: http://hdl.handle.net/2144/41309
► BACKGROUND: Mild cognitive impairment (MCI) is a clinical condition that is characterized by mild changes in cognition. The amnestic form of MCI (aMCI) primarily affects…
(more)
▼ BACKGROUND:
Mild cognitive impairment (MCI) is a clinical condition that is characterized by
mild changes in cognition. The amnestic form of MCI (aMCI) primarily affects memory and is thought to represent a stage between healthy aging and Alzheimer’s disease (AD). The medial temporal lobe (MTL) and the limbic system are two areas of the brain that have been implicated in the amnestic form of MCI. While MCI represents a risk factor for AD, it does not always lead to dementias. Being a carrier of the APOE Ɛ4 allele has also shown to increase chances of progression from MCI to AD.
OBJECTIVE: To determine whether the subnuclei of the amygdala, along with other specific regions within the MTL, can differentiate between cognitively normal individuals and age-matched subjects with aMCI.
METHODS: T1-weighted magnetic resonance imaging (MRI) data from two sources, the Boston University Alzheimer’s Disease Center (BU-ADC) and the Alzheimer’s Disease Neuroimaging Initiative (ADNI), was compiled for cross-sectional analysis. 95 scans in total from 45 cognitively normal participants and 50 diagnosed with aMCI were analyzed and the volumes of interest were automatically generated by the developmental version of FreeSurfer v6.0. To evaluate how well the volumes could predict either group membership (i.e. control group or MCI group) or APOE Ɛ4 status (i.e. carrier or noncarrier), the variables were assessed by nominal logistic regression models.
RESULTS: Six of the nine nuclei of the amygdala had significantly reduced volumes in the aMCI group compared to controls. The whole amygdala and the perirhinal cortex also demonstrated reduced volumes in the aMCI group compared to the control group. The whole amygdala was a good predictor of group membership (R2 = 0.1386, whole model test chi square = 18.21558, p = 0.0004), but none of the subnuclei were good predictors individually. A model containing the 9 nuclei, the entorhinal cortex, and the perirhinal cortex provided a good fit for predicting APOE Ɛ4 status fit (R2 = 0.3000, whole model test chi square = 36.29563, p = 0.0002) and the best predictor was the corticoamygdaloid transition area of the amygdala.
CONCLUSIONS: The results of our study confirm previous findings of reduced whole amygdala volume and add to the limited literature of reduced perirhinal cortex and amygdaloid nuclei volumes in MCI compared to healthy controls. To the best of our knowledge, this was the first time the automatic segmentation atlas was used to analyze the volumes of nine subnuclei of the amygdala in a population of aMCI. Our model testing the volume of the whole amygdala accurately predicted aMCI subjects with 58% accuracy and controls with 70% accuracy; the accuracy rose to 69% when the entorhinal cortex and the perirhinal cortex were added to the model to predict aMCI subjects from controls. Additionally, the model for predicting APOE Ɛ4 status identified noncarriers of the allele at 85% accuracy. Future studies should consider increasing the sample size to better assess small ROIs and assess for…
Advisors/Committee Members: Killiany, Ronald J. (advisor), Mian, Asim (advisor).
Subjects/Keywords: Neurosciences; Amnestic mild cognitive impairment; Amygdala; Amygdala nuclei; Amygdala subnuclei; Mild cognitive impairment; Perirhinal cortex
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APA (6th Edition):
Murati, A. (2020). The automatic segmentation of the human amygdala in amnestic mild cognitive impairment. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/41309
Chicago Manual of Style (16th Edition):
Murati, Anastasia. “The automatic segmentation of the human amygdala in amnestic mild cognitive impairment.” 2020. Masters Thesis, Boston University. Accessed January 17, 2021.
http://hdl.handle.net/2144/41309.
MLA Handbook (7th Edition):
Murati, Anastasia. “The automatic segmentation of the human amygdala in amnestic mild cognitive impairment.” 2020. Web. 17 Jan 2021.
Vancouver:
Murati A. The automatic segmentation of the human amygdala in amnestic mild cognitive impairment. [Internet] [Masters thesis]. Boston University; 2020. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/2144/41309.
Council of Science Editors:
Murati A. The automatic segmentation of the human amygdala in amnestic mild cognitive impairment. [Masters Thesis]. Boston University; 2020. Available from: http://hdl.handle.net/2144/41309
Macquarie University
24.
McCade, Donna.
Emotion recognition in mild cognitive impairment.
Degree: 2012, Macquarie University
URL: http://hdl.handle.net/1959.14/267332
► Empirical thesis submitted in partial fulfilment of the requirements of the degree of Doctor of Psychology (Clinical Neuropsychology), Macquarie University, 2012.
Thesis by publication.
1.…
(more)
▼ Empirical thesis submitted in partial fulfilment of the requirements of the degree of Doctor of Psychology (Clinical Neuropsychology), Macquarie University, 2012.
Thesis by publication.
1. Dementia and the concept of mild cognitive impairment – 2. Literature review: emotion recognition and mild cognitive impairment – 3. Mild cognitive impairment and emotion recognition: research aims and hypotheses – 4. Study 1 – 5. Study 2 – 6. Discussion.
The aims of this research were firstly, to investigate whether emotion recognition abilities differ amongst Mild Cognitive Impairment (MCI) subtypes and secondly, to explore the real-life implications of emotion recognition deficits in MCI patients. In Study 1, 19 MCI patients with predominantly impaired memory (i.e., amnestic MCI; aMCI), 18 MCI patients with non-memory deficits (i.e., non-amnestic MCI; naMCI) and 19 age- and education-matched healthy control subjects were assessed with three emotion recognition tests differing in task demands (i.e., the provision of response prompts, facial or bodily displays of affect). Emotion recognition deficits were shown for aMCI, but not naMCI, patients regardless of task demands, with anger recognition selectively impaired. In Study 2, the emotion recognition abilities of 29 aMCI patients, 27 naMCI patients, and 22 control subjects were assessed. Self-report measures assessed subject functional disability, whilst informants rated caregiver burden. An emotion recognition deficit for anger was evident again for the amnestic subtype. Whilst patient groups reported greater social dysfunction than control subjects, a relationship between social functioning and anger recognition was evident only for naMCI patients. Caregiver burden and anger recognition were significantly associated for aMCI patients. Results suggest that impaired emotion recognition abilities are differentially affected in MCI subtypes potentially reflecting diverse degeneration of brain structures modulating emotional processing. Screening to detect emotion recognition impairment in MCI patients and interventions targeted at patients and caregivers is warranted.
1 online resource (xii, 214 pages)
Advisors/Committee Members: Macquarie University. Dept. of Psychology.
Subjects/Keywords: Mild cognitive impairment; Emotions and cognition; Recognition (Psychology); emotion recognition; mild cognitive impairment
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APA (6th Edition):
McCade, D. (2012). Emotion recognition in mild cognitive impairment. (Thesis). Macquarie University. Retrieved from http://hdl.handle.net/1959.14/267332
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
McCade, Donna. “Emotion recognition in mild cognitive impairment.” 2012. Thesis, Macquarie University. Accessed January 17, 2021.
http://hdl.handle.net/1959.14/267332.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
McCade, Donna. “Emotion recognition in mild cognitive impairment.” 2012. Web. 17 Jan 2021.
Vancouver:
McCade D. Emotion recognition in mild cognitive impairment. [Internet] [Thesis]. Macquarie University; 2012. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/1959.14/267332.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
McCade D. Emotion recognition in mild cognitive impairment. [Thesis]. Macquarie University; 2012. Available from: http://hdl.handle.net/1959.14/267332
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
25.
Wu-Puigbo, Ya-Huei.
Validation d'un test de barrage informatisé sur tablette évaluant les fonctions exécutives auprès d'une population gériatrique : Validation of a tablet-based cancellation test assessing executive function in older adults.
Degree: Docteur es, Psychologie, 2016, Sorbonne Paris Cité
URL: http://www.theses.fr/2016USPCB210
► Dans le contexte du diagnostic précoce de la maladie d’Alzheimer, une direction de la recherche émerge autour de l’informatisation de tests cognitifs. Nous avons conçu…
(more)
▼ Dans le contexte du diagnostic précoce de la maladie d’Alzheimer, une direction de la recherche émerge autour de l’informatisation de tests cognitifs. Nous avons conçu un test de barrage informatisé sur tablette (test e-CT), développé à partir d’un test de barrage papier-crayon. Nous avons étudié les variables influençant les performances au test e-CT et ses propriétés psychométriques. Nous avons observé que chez les sujets âgés sains, la seule variable influençant était l’âge. Les performances au test e-CT n’étaient pas influencées par l’expérience avec un appareil informatique. Cependant, chez les patients présentant des troubles cognitifs, ceux qui utilisaient quotidiennement un appareil informatique avaient une meilleure performance que ceux qui n’avaient pas un usage quotidien. En effet, les patients utilisant quotidiennement un appareil informatique présentaient de meilleures capacités cognitives. Le test e-CT était corrélé avec plusieurs tests des fonctions exécutives (validité convergente), mais pas avec le test de la mémoire épisodique (validité divergente). Il présente aussi une bonne fidélité test-retest. Le test e-CT présente des bonnes performances diagnostiques, permettant de différencier les personnes âgées saines des patients présentant des troubles cognitifs. En conclusion, le test e-CT présente des propriétés psychométriques satisfaisantes et peut être utilisé pour l’évaluation cognitive chez le sujet âgé.
In the context of early detection of cognitive impairment associated with dementia, an area of research focus concerns development and validation of computerized tests. We have developed a tablet-based cancellation test (e-CT), based on an existing paper-and-pencil cancellation test (K-T test). We studied the variables influencing performance on the e-CT and its psychometric properties. Among healthy older adults, only age was found to be an influencing variable. The performance on the e-CT was not influenced by experience with a computer-based device. However, for patients suffering from cognitive impairment, those using a computer-based device daily outperformed those who were not daily users. Further analyses showed that daily users conserved better cognitive capacities than non-daily users. The e-CT showed significant correlations with several measures of executive functions (convergent validity), but there was no relationship between the e-CT and the episodic memory test (divergent validity). It showed good test-retest reliability. The e-CT had good diagnostic accuracy in differentiating between healthy elderly subjects and patients with cognitive impairment. In conclusion, the e-CT test shows satisfying psychometric properties and is a promising tool for neuropsychological assessment in older adults
Advisors/Committee Members: Rigaud, Anne-Sophie (thesis director).
Subjects/Keywords: Fonctions exécutives; Tests cognitifs informatisés; Mild cognitive impairment; Maladie d'Alzheimer; Executive functions; Computerized cognitive assessment; Mild cognitive impairment; Alzheimer's disease; 616.831
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Wu-Puigbo, Y. (2016). Validation d'un test de barrage informatisé sur tablette évaluant les fonctions exécutives auprès d'une population gériatrique : Validation of a tablet-based cancellation test assessing executive function in older adults. (Doctoral Dissertation). Sorbonne Paris Cité. Retrieved from http://www.theses.fr/2016USPCB210
Chicago Manual of Style (16th Edition):
Wu-Puigbo, Ya-Huei. “Validation d'un test de barrage informatisé sur tablette évaluant les fonctions exécutives auprès d'une population gériatrique : Validation of a tablet-based cancellation test assessing executive function in older adults.” 2016. Doctoral Dissertation, Sorbonne Paris Cité. Accessed January 17, 2021.
http://www.theses.fr/2016USPCB210.
MLA Handbook (7th Edition):
Wu-Puigbo, Ya-Huei. “Validation d'un test de barrage informatisé sur tablette évaluant les fonctions exécutives auprès d'une population gériatrique : Validation of a tablet-based cancellation test assessing executive function in older adults.” 2016. Web. 17 Jan 2021.
Vancouver:
Wu-Puigbo Y. Validation d'un test de barrage informatisé sur tablette évaluant les fonctions exécutives auprès d'une population gériatrique : Validation of a tablet-based cancellation test assessing executive function in older adults. [Internet] [Doctoral dissertation]. Sorbonne Paris Cité; 2016. [cited 2021 Jan 17].
Available from: http://www.theses.fr/2016USPCB210.
Council of Science Editors:
Wu-Puigbo Y. Validation d'un test de barrage informatisé sur tablette évaluant les fonctions exécutives auprès d'une population gériatrique : Validation of a tablet-based cancellation test assessing executive function in older adults. [Doctoral Dissertation]. Sorbonne Paris Cité; 2016. Available from: http://www.theses.fr/2016USPCB210
Drexel University
26.
Truelove-Hill, Monica.
Using Machine Learning to Differentiate between Healthy Aging, Mild Cognitive Impairment, & Alzheimer’s Disease.
Degree: 2018, Drexel University
URL: https://idea.library.drexel.edu/islandora/object/idea%3A8145
► Alzheimer’s disease (AD) is an insidious disorder in which pathology may develop decades before outward symptoms become apparent. Identification of this disease in its earliest…
(more)
▼ Alzheimer’s disease (AD) is an insidious disorder in which pathology may develop decades before outward symptoms become apparent. Identification of this disease in its earliest stages would provide the greatest opportunity for successful treatment. Current recommendations place patients in groups based primarily upon CSF -amyloid (A) levels, but the procedure to gather these data is invasive. If less intrusive methods could be identified to successfully predict which individuals are especially prone to develop AD, the benefits would be invaluable. Many studies have attempted to identify these individuals using neuroimaging methods such as MRI or PET, but very few studies have incorporated EEG data, despite research indicating its relationship with AD pathology. In this analysis, multimodal classifiers incorporating EEG, MRI, and PET data were developed and used in an attempt to differentiate between AD patients and a healthy control group, as well as MCI patients with AD A pathology and those without. Additionally, repeated-measures event-related potential (ERP) data were analyzed to directly examine changes related to AD progression.
Ph.D., Psychology – Drexel University, 2018
Advisors/Committee Members: Kounios, John, College of Arts and Sciences.
Subjects/Keywords: Psychology; Cognitive psychology; Alzheimer's disease; Machine learning; Mild cognitive impairment
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APA (6th Edition):
Truelove-Hill, M. (2018). Using Machine Learning to Differentiate between Healthy Aging, Mild Cognitive Impairment, & Alzheimer’s Disease. (Thesis). Drexel University. Retrieved from https://idea.library.drexel.edu/islandora/object/idea%3A8145
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Truelove-Hill, Monica. “Using Machine Learning to Differentiate between Healthy Aging, Mild Cognitive Impairment, & Alzheimer’s Disease.” 2018. Thesis, Drexel University. Accessed January 17, 2021.
https://idea.library.drexel.edu/islandora/object/idea%3A8145.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Truelove-Hill, Monica. “Using Machine Learning to Differentiate between Healthy Aging, Mild Cognitive Impairment, & Alzheimer’s Disease.” 2018. Web. 17 Jan 2021.
Vancouver:
Truelove-Hill M. Using Machine Learning to Differentiate between Healthy Aging, Mild Cognitive Impairment, & Alzheimer’s Disease. [Internet] [Thesis]. Drexel University; 2018. [cited 2021 Jan 17].
Available from: https://idea.library.drexel.edu/islandora/object/idea%3A8145.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Truelove-Hill M. Using Machine Learning to Differentiate between Healthy Aging, Mild Cognitive Impairment, & Alzheimer’s Disease. [Thesis]. Drexel University; 2018. Available from: https://idea.library.drexel.edu/islandora/object/idea%3A8145
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Newcastle
27.
Cui, Yue.
Use of pattern classification to identify mild cognitive impairment and predict cognitive decline.
Degree: PhD, 2011, University of Newcastle
URL: http://hdl.handle.net/1959.13/930112
► Research Doctorate - Doctor of Philosophy (PhD)
Alzheimer’s disease (AD) is the most common cause of dementia in older people, with the prevalence doubling for…
(more)
▼ Research Doctorate - Doctor of Philosophy (PhD)
Alzheimer’s disease (AD) is the most common cause of dementia in older people, with the prevalence doubling for every 5-year interval beyond the age of 65. The combination of our ageing society and the broad-reaching and devastating impacts of AD make research into this disease an urgent priority. A desirable aim of such research is to develop means of making early and accurate diagnoses of individuals who either have or are at increased risk of developing AD. This will allow for timely interventions that may be effective in managing or treating AD. There is a cognitive continuum from normal ageing to dementia, with mild cognitive impairment (MCI) being a syndrome widely considered to be a prodromal stage of dementia. In this thesis, pattern classification algorithms were used for the identification of MCI and prediction of decline from normal cognition to MCI, and MCI to AD. Three studies were conducted: (1) identification of amnestic MCI among community-dwelling elderly adults, (2) prediction of the transition from normal cognition to MCI in community-dwelling elderly adults, and (3) prediction of the conversion from amnestic MCI to AD in a clinic-based sample. Due to there being only subtle brain changes in the very early stages of cognitive decline, early diagnosis is particularly challenging. The first study investigated the automated detection of MCI using a combination of spatial atrophy and white matter alterations, as changes in both brain structure and the capacity for information flow within and between structures are important contributors to cognitive dysfunction. Additionally, numerous socio-demographic, lifestyle, health and other factors were implicated in the misclassification of individuals. The second study used neuropsychological test scores and neuroimaging morphological measures to identify cognitively normal individuals at increased risk of developing MCI, and appears to be the first study to use pattern classification methods for this purpose. The third study investigated conversion from MCI to AD using multimodal data that included cerebrospinal fluid (CSF) protein concentrations, neuroimaging, and neuropsychological test scores. The classification and prediction schema used in these studies comprised feature extraction, feature selection and classification stages. Using an automated feature extraction process, measurements of brain structures were computed from neuroimages. In addition to these, cognitive data obtained from neuropsychological assessments and CSF biomarker data were also used. Meaningful features, which enabled optimal differentiation between cognitive groups, were then identified from the range of neuroimage, neuropsychological and CSF biomarker features using a feature selection process. In the classification stage, non-linear support vector machines were then used to train classifiers and test classification performance. These pattern classification methods achieved a high level of performance in all three studies. In…
Advisors/Committee Members: University of Newcastle. Faculty of Science and Information Technology, School of Design, Communication and Information Technology.
Subjects/Keywords: mild cognitive impairment; Alzheimer’s disease; dementia; pattern classification; cognitive decline
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APA (6th Edition):
Cui, Y. (2011). Use of pattern classification to identify mild cognitive impairment and predict cognitive decline. (Doctoral Dissertation). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/930112
Chicago Manual of Style (16th Edition):
Cui, Yue. “Use of pattern classification to identify mild cognitive impairment and predict cognitive decline.” 2011. Doctoral Dissertation, University of Newcastle. Accessed January 17, 2021.
http://hdl.handle.net/1959.13/930112.
MLA Handbook (7th Edition):
Cui, Yue. “Use of pattern classification to identify mild cognitive impairment and predict cognitive decline.” 2011. Web. 17 Jan 2021.
Vancouver:
Cui Y. Use of pattern classification to identify mild cognitive impairment and predict cognitive decline. [Internet] [Doctoral dissertation]. University of Newcastle; 2011. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/1959.13/930112.
Council of Science Editors:
Cui Y. Use of pattern classification to identify mild cognitive impairment and predict cognitive decline. [Doctoral Dissertation]. University of Newcastle; 2011. Available from: http://hdl.handle.net/1959.13/930112
28.
E. Rotondo.
PROGRESSIONE DA MILD COGNITIVE IMPAIRMENT A MALATTIA DI ALZHEIMER: IDENTIFICAZIONE DI PROFILI NEUROCOGNITIVI PREDITTIVI E CORRELAZIONE CON BIOMARCATORI LIQUORALI.
Degree: 2012, Università degli Studi di Milano
URL: http://hdl.handle.net/2434/173979
► Objective: To correlate neuropsychological testing with cerebrospinal fluid Amyloid beta (AD), tau and Ptau levels in patients with Mild Cognitive Impairment (MCI) Background: Principal diagnostic…
(more)
▼ Objective: To correlate neuropsychological testing with cerebrospinal fluid Amyloid beta (AD), tau and Ptau levels in patients with
Mild Cognitive Impairment (MCI)
Background: Principal diagnostic instrument to define global
cognitive state is the Mini Mental State Examination (MMSE).
Cognitive domains that best predict progression from amnestic MCI to AD are episodic memory and executive functioning. Were selected two neuropsychological tests for both domains: Story Recall Test (SRT) and Paired-Associate Learning (PAL) to examine episodic verbal memory, and Coloured Progressive Matrices of Raven (CPMR) and Clock Drawing Test (CDT) to investigate executive functioning.
Methods: Forty subjects with amnestic MCI were recruited. All of them underwent neurological exam, neuropsychological testing and lumbar puncture at time of diagnosis. Cognition were explored by MMSE (global
cognitive functioning), CPMR and CDT (executive functions), SRT and PAL (episodic verbal memory). Statistical analysis was carried out by using t-test and Spearman test for correlations.
Results: In the whole population, no significant correlation between
cognitive and biological markers was observed. Considering CSF biomarker level of amiloidβ, thirteen subjects showed an altered pattern and converted to AD after few months, the other subjects whit a normal profile did not convert.
MMSE show a significant difference between converters/no converters groups (26.4 versus 27.6 p=0.066). Also CDT and SRT had a significant difference between two groups (3 versus 5 p= 0.003 and 5.85 versus 8.32, p=0.03).
Conclusion: According to these results, MMSE value is lower in converters, in according to patological biomarkers profile. PAL and CDT are more specific to predict conversion from MCI to AD.
Advisors/Committee Members: tutor: L. Bergamaschini, supervisori: E. A. Scarpini, D. Galimberti, coordinatore: R. Weinstein, BERGAMASCHINI, LUIGI CESARE, WEINSTEIN, ROBERTO LODOVICO.
Subjects/Keywords: mild cognitive impairment; cognitive markers; Settore MED/09 - Medicina Interna
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APA (6th Edition):
Rotondo, E. (2012). PROGRESSIONE DA MILD COGNITIVE IMPAIRMENT A MALATTIA DI ALZHEIMER: IDENTIFICAZIONE DI PROFILI NEUROCOGNITIVI PREDITTIVI E CORRELAZIONE CON BIOMARCATORI LIQUORALI. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/173979
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Rotondo, E.. “PROGRESSIONE DA MILD COGNITIVE IMPAIRMENT A MALATTIA DI ALZHEIMER: IDENTIFICAZIONE DI PROFILI NEUROCOGNITIVI PREDITTIVI E CORRELAZIONE CON BIOMARCATORI LIQUORALI.” 2012. Thesis, Università degli Studi di Milano. Accessed January 17, 2021.
http://hdl.handle.net/2434/173979.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Rotondo, E.. “PROGRESSIONE DA MILD COGNITIVE IMPAIRMENT A MALATTIA DI ALZHEIMER: IDENTIFICAZIONE DI PROFILI NEUROCOGNITIVI PREDITTIVI E CORRELAZIONE CON BIOMARCATORI LIQUORALI.” 2012. Web. 17 Jan 2021.
Vancouver:
Rotondo E. PROGRESSIONE DA MILD COGNITIVE IMPAIRMENT A MALATTIA DI ALZHEIMER: IDENTIFICAZIONE DI PROFILI NEUROCOGNITIVI PREDITTIVI E CORRELAZIONE CON BIOMARCATORI LIQUORALI. [Internet] [Thesis]. Università degli Studi di Milano; 2012. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/2434/173979.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Rotondo E. PROGRESSIONE DA MILD COGNITIVE IMPAIRMENT A MALATTIA DI ALZHEIMER: IDENTIFICAZIONE DI PROFILI NEUROCOGNITIVI PREDITTIVI E CORRELAZIONE CON BIOMARCATORI LIQUORALI. [Thesis]. Università degli Studi di Milano; 2012. Available from: http://hdl.handle.net/2434/173979
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – San Diego
29.
Ingram, Katherine.
Pattern Separation in Healthy Aging and Dementia.
Degree: Psychology, 2015, University of California – San Diego
URL: http://www.escholarship.org/uc/item/9hc234zf
► The dissertation research described herein examined several facets of pattern separation (conceptualized as an encoding process whereby two very similar stimuli are stored as discrete…
(more)
▼ The dissertation research described herein examined several facets of pattern separation (conceptualized as an encoding process whereby two very similar stimuli are stored as discrete representations). Previous research has conceptualized pattern separation as a discrete, high threshold process and has relied upon performance measures that are derived from that theory. More recently, it has been suggested that pattern separation may be better fit by a continuous, signal-detection-based model. Should that be the case, it would mean that previous work examining pattern separation in aging and dementia has relied upon potentially misleading dependent measures. The current project had three goals: 1) to determine the most appropriate cognitive modeling for pattern separation, 2) to examine whether or not pattern separation is selectively impaired in aging and dementia populations, and 3) to compare biomarkers of preclinical impairment with performance on behavioral recognition memory and pattern separation tasks. In Chapter 1, ROC and d’ analyses showed that pattern separation is indeed best conceptualized as a continuous signal detection process. In Chapters 2 and 3, we took the framework for pattern separation identified in Chapter 1 and applied it to a population consisting of young adults, older adults, individuals with amnestic mild cognitive impairment (aMCI), and Alzheimer’s disease. The general approach was to first try to equate performance across groups on a recognition memory task and then compare group performance on the pattern separation task. Taken together, Chapters 2 and 3 provided evidence that pattern separation is selectively impaired in aMCI and possibly in healthy older adults as well, and this deficit is not explained by a recognition deficit alone. In Chapter 4 we measured the relationship between behavioral performance measures (on both the recognition memory tasks and pattern separation tasks) and cerebrospinal fluid biomarkers (Aβ42 and tau levels) in healthy aging participants. We found a significant positive correlation between performance on both the recognition memory task and the pattern separation task, but only for pictures of everyday objects. Thus, these biomarkers are predictive of general memory performance for objects but do not selectively predict pattern separation performance.
Subjects/Keywords: Cognitive psychology; healthy aging; mild cognitive impairment; pattern separation; preclinical impairment; signal detection theory
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APA (6th Edition):
Ingram, K. (2015). Pattern Separation in Healthy Aging and Dementia. (Thesis). University of California – San Diego. Retrieved from http://www.escholarship.org/uc/item/9hc234zf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Ingram, Katherine. “Pattern Separation in Healthy Aging and Dementia.” 2015. Thesis, University of California – San Diego. Accessed January 17, 2021.
http://www.escholarship.org/uc/item/9hc234zf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Ingram, Katherine. “Pattern Separation in Healthy Aging and Dementia.” 2015. Web. 17 Jan 2021.
Vancouver:
Ingram K. Pattern Separation in Healthy Aging and Dementia. [Internet] [Thesis]. University of California – San Diego; 2015. [cited 2021 Jan 17].
Available from: http://www.escholarship.org/uc/item/9hc234zf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Ingram K. Pattern Separation in Healthy Aging and Dementia. [Thesis]. University of California – San Diego; 2015. Available from: http://www.escholarship.org/uc/item/9hc234zf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Florida Atlantic University
30.
Powers-Jarvis, Robin Story.
Recognizing Functional Decline in Persons with MCI (Mild Cognitive Impairment).
Degree: 2015, Florida Atlantic University
URL: http://purl.flvc.org/fau/fd/FA00004536
► Summary: Although not all persons with mild cognitive impairment (MCI) go on to develop Alzheimer's disease (AD), MCI is recognized as an early stage of…
(more)
▼ Summary: Although not all persons with mild cognitive impairment (MCI) go on to develop Alzheimer's disease (AD), MCI is recognized as an early stage of AD. The effects of AD are devastating to all concerned. Research has identified that recognition of AD in its earliest stages and institution of known treatment modalities can forestall the ultimate outcome. Identification of the first subtle signs of MCI can assist in the recognition of this prodromal phase, and allow for institution of therapy while still in the initial stages. Unfortunately, the development of MCI is insidious in nature, thus making it difficult to detect. The purpose of this study was to identify areas of functional decline that occur in MCI in an effort to improve its early identification. A mixed-methods design that combined qualitative and quantitative methods was used. Fifty-three participants with memory complaints were interviewed using a semi structured interview technique with open-ended questions, the Montreal Cognitive Assessment (MoCA), the Geriatric Depression Scale (GDS) and a list of eighty-five items previously identified as indicative of functional decline. Twenty-nine persons were divided into two groups: 1) those identified as probable MCI (consensus diagnosis) (n=15) and possible MCI (based on screening examination) (n=14) and 2) those identified as Normal (no cognitive impairment) (n=10), and their subjective functional deficits compared. The findings suggest that there were certain areas of functional decline more commonly experienced by persons in the MCI group than by unimpaired. These include difficulty recalling details of information and forgetting conversations. There were also other changes identified, such as adaptations on the part of persons with MCI (an increased dependence on memory aids, for example, lists and calendars) and a dec rease in social activities leading to an increase in social isolation. Additionally identified were functional activities that appear to remain intact in persons with early MCI. This study highlights the subtlety with which MCI assaults the functional abilities of individuals, thus making its early identification problematic. The results of this study will contribute by providing information that will help professionals who are assessing persons experiencing memory issues for the possible presence of MCI. Additionally, it is hoped that these findings will assist in the development of a measurement tool designed to assess for possible MCI.
2015
Degree granted: Dissertation (Ph.D.) – Florida Atlantic University, 2015.
Collection: FAU
Advisors/Committee Members: Tappen, Ruth M. (Thesis advisor), Florida Atlantic University (Degree grantor), Christine E. Lynn College of Nursing.
Subjects/Keywords: Alzheimer's disease – Diagnosis; Amnestic mild cognitive impairment – Diagnosis; Dementia – Diagnosis; Memory disorders in old age – Diagnosis; Mild cognitive impairment – Diagnosis
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Powers-Jarvis, R. S. (2015). Recognizing Functional Decline in Persons with MCI (Mild Cognitive Impairment). (Thesis). Florida Atlantic University. Retrieved from http://purl.flvc.org/fau/fd/FA00004536
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Powers-Jarvis, Robin Story. “Recognizing Functional Decline in Persons with MCI (Mild Cognitive Impairment).” 2015. Thesis, Florida Atlantic University. Accessed January 17, 2021.
http://purl.flvc.org/fau/fd/FA00004536.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Powers-Jarvis, Robin Story. “Recognizing Functional Decline in Persons with MCI (Mild Cognitive Impairment).” 2015. Web. 17 Jan 2021.
Vancouver:
Powers-Jarvis RS. Recognizing Functional Decline in Persons with MCI (Mild Cognitive Impairment). [Internet] [Thesis]. Florida Atlantic University; 2015. [cited 2021 Jan 17].
Available from: http://purl.flvc.org/fau/fd/FA00004536.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Powers-Jarvis RS. Recognizing Functional Decline in Persons with MCI (Mild Cognitive Impairment). [Thesis]. Florida Atlantic University; 2015. Available from: http://purl.flvc.org/fau/fd/FA00004536
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
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Open Access Theses and Dissertations