subject:(microbiota)

University of Edinburgh

1. Glendinning, Laura. Sheep lung microbiota.

Degree: PhD, 2017, University of Edinburgh

► Until recently it was assumed that the healthy mammalian lung did not harbour a microbiota, unlike other body sites. However, through the use of sequencing… (more)

▼ Until recently it was assumed that the healthy mammalian lung did not harbour a microbiota, unlike other body sites. However, through the use of sequencing based technologies this has been shown to not be the case. Low biomass communities of microbes can be identified in the healthy lung and the lung microbiota in various diseases states has been shown to differ form these 'healthy' communities. The sheep respiratory microbiota is of interest from both an animal health perspective and due to the potential use of the sheep as a large animal model for studying the lung microbiota. In this thesis I seek to characterise the composition and variability of the sheep lung microbiota; the differences between the sheep upper and lower respiratory tract bacterial communities and to assess whether exhaled breath condensate collection can be used as a non-invasive lung microbiota sampling method. To study the bacterial communities present in samples I have used 16S rRNA gene sequencing and analysis. In Chapter 3 I examine the inter-individual and spatial variability present within the sheep lung microbiota. Protected specimen brushings were collected from three lung segments in six animals at three time-points. In a separate sheep a greater number of brushings was taken (n=16) in order to examine the amount of variability over a smaller spatial scale. I find that there can be large differences between the bacterial communities isolated from different locations within the lung, even over short distances. Samples also cluster by the sheep from which they were taken, indicating a host specific influence on the lung microbiota. In Chapter 4 I compare whole lung washes and oropharyngeal swabs from 40 lambs in order to examine the differences between the upper and lower respiratory tract microbiotas. I find that oropharyngeal swabs separate into rumen-like or upper respiratory tract-like bacterial communities. Despite the fact that in humans the upper and lower respiratory microbiotas have been shown to have similar compositions, the sheep lung microbiota samples in this study do not resemble either oropharyngeal samples or reagent only controls. In my first two results chapters, lung sampling methods were used which involved either anaesthesia combined with a bronchoscopic procedure (Chapter 3) or samples being taken from dead animals (Chapter 4). In Chapter 5 I assess whether there is a less invasive way of taking lung microbiota samples from a living individual, both to minimise the procedural stress on animals used as models and to increase the pool of potential volunteers for human lung microbiota studies. I compared samples taken via protected specimen brushings to samples taken via exhaled breath condensate collection, a less invasive sampling technique. I find that condensate samples contain less bacterial DNA and different bacteria than brushing samples, indicating that it is unlikely they could be used as a replacement for invasive sampling methods. In my final results chapter I compare the results across Chapters 3, 4 and 5…

Subjects/Keywords: lung microbiota; sheep microbiota; 16S

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APA (6^th Edition):

Glendinning, L. (2017). Sheep lung microbiota. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/29541

Chicago Manual of Style (16^th Edition):

Glendinning, Laura. “Sheep lung microbiota.” 2017. Doctoral Dissertation, University of Edinburgh. Accessed January 23, 2021. http://hdl.handle.net/1842/29541.

MLA Handbook (7^th Edition):

Glendinning, Laura. “Sheep lung microbiota.” 2017. Web. 23 Jan 2021.

Vancouver:

Glendinning L. Sheep lung microbiota. [Internet] [Doctoral dissertation]. University of Edinburgh; 2017. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1842/29541.

Council of Science Editors:

Glendinning L. Sheep lung microbiota. [Doctoral Dissertation]. University of Edinburgh; 2017. Available from: http://hdl.handle.net/1842/29541

McMaster University

2. Perez Guzman, Elizabeth. Functional Relationship Between Gut Microbiota and Anxiety.

Degree: MSc, 2017, McMaster University

URL: http://hdl.handle.net/11375/22310

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Depression and anxiety are etiologically heterogeneous disorders and their pathophysiology remains largely unknown. Gut microbiota has been shown to modulate brain function, behavior, and immune… (more)

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Depression and anxiety are etiologically heterogeneous disorders and their pathophysiology remains largely unknown. Gut microbiota has been shown to modulate brain function, behavior, and immune responses, and it has also been proposed to play a role in the pathophysiology of depression and anxiety. Our study aimed to investigate whether microbiota from patients with Generalized Anxiety Disorder (GAD) can induce anxiety and depressive-like behaviour in germ-free mice and whether this is accompanied by changes in immune markers and brain activity. Germ-free NIH Swiss mice (n=27) were colonized with microbiota from either a GAD patient (n=13) with severe anxiety and comorbid depression or an age and sex-matched healthy control (HC) (n=14). Six mice from each group were treated with infliximab for three weeks (5mg/kg/week) starting at week 1 post-colonization. Microbiota profiles were assessed via 16S rRNA based Illumina. Three weeks post-colonization, all mice underwent six standard psychometric tests, including the open field, digging, marble-burying, and tail-suspension test. Cecal -defensin-3 and serum kynurenine/tryptophan were measured via ELISA. BDNF expression was assessed by immunofluorescence, and gene expression by using Nanostring gene assay. Fecal -defensin levels were higher in GAD patients than in healthy controls. Similarly, -defensin levels were higher in GAD-colonized mice than in HC-colonized mice. GAD and HC-colonized mice had a unique and distinct microbiota, similar to that of their respective human donors. GAD-colonized mice exhibited anxiety and depressive-like behavior compared to HC- colonized mice, as assessed by the open field, digging, marble burying and tail suspension tests. BDNF expression was decreased in the hippocampus but increased in the amygdala of GAD-colonized mice. GAD-colonized mice also had a greater kynurenine/tryptophan ratio than HC-colonized mice. GAD and HC infliximab-treated mice showed no differences in behavior, central BDNF expression or kynurenine/tryptophan levels. Our results suggest that GAD microbiota has the ability to induce anxiety and depressive-like behavior and alter brain BDNF expression in a murine host. These changes are accompanied by the activation of the innate immune system and seem to be TNF- dependent.

Thesis

Master of Science (MSc)

Advisors/Committee Members: Bercik, Premysl, Medical Sciences (Division of Physiology/Pharmacology).

Subjects/Keywords: microbiota; anxiety

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APA (6^th Edition):

Perez Guzman, E. (2017). Functional Relationship Between Gut Microbiota and Anxiety. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/22310

Chicago Manual of Style (16^th Edition):

Perez Guzman, Elizabeth. “Functional Relationship Between Gut Microbiota and Anxiety.” 2017. Masters Thesis, McMaster University. Accessed January 23, 2021. http://hdl.handle.net/11375/22310.

MLA Handbook (7^th Edition):

Perez Guzman, Elizabeth. “Functional Relationship Between Gut Microbiota and Anxiety.” 2017. Web. 23 Jan 2021.

Vancouver:

Perez Guzman E. Functional Relationship Between Gut Microbiota and Anxiety. [Internet] [Masters thesis]. McMaster University; 2017. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/11375/22310.

Council of Science Editors:

Perez Guzman E. Functional Relationship Between Gut Microbiota and Anxiety. [Masters Thesis]. McMaster University; 2017. Available from: http://hdl.handle.net/11375/22310

McMaster University

3. Dupont, Haley. Examining abiotic and biotic factors influencing bacterial and host interactions in the female reproductive tract.

Degree: MSc, 2020, McMaster University

URL: http://hdl.handle.net/11375/25387

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Currently, the leading route of new HIV-1 infection is via heterosexual transmission, in which women are disproportionately burdened. One key factor associated with a fourfold… (more)

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Currently, the leading route of new HIV-1 infection is via heterosexual transmission, in which women are disproportionately burdened. One key factor associated with a fourfold increased risk of HIV-1 acquisition is a dysbiotic vaginal microbiota (VMB). A dysbiotic VMB is characterized by a diverse mix of anaerobic species without any appreciable amounts of beneficial Lactobacillus species. Our understanding of the species-specific manner by which vaginal bacteria interact with one another and with the host to induce susceptibility remains incompletely understood. With this, this study was designed to elucidate the interactions between common vaginal bacteria and host vaginal epithelial cells. The phenotypic and metabolic characteristics of these bacteria were also examined to provide a deeper understanding about the conditions in which each species may be able to survive and thrive. Common vaginal bacteria analyzed included dysbiosis associated species Gardnerella vaginalis and Prevotella bivia, as well as Lactobacillus species L. crispatus and L. iners. The presence of P. bivia, G. vaginalis and L. iners cocultured with vaginal epithelial cells in vitro resulted in reduced viability of vaginal epithelial cells, reduced barrier integrity and the production of pro-inflammatory cytokines. Conversely, the presence of L. crispatus did not, and was able to negate these adverse effects when placed in a dual species coculture with either of the other species. Additionally, we found that L. crispatus was the only one of these four species to produce hydrogen peroxide, and its supernatant was capable of inhibiting the growth of G. vaginalis and P. bivia. While we found that all four vaginal species could use glycogen for their growth, L. crispatus was able to use the widest range of carbohydrates tested. This translated to L. crispatus significantly outcompeting the other three bacterial species when cocultured in bacterial broth media with various carbohydrates tested. Our data provides insight into the species-specific nature by which common vaginal bacteria may interact with vaginal epithelial cells to increase host susceptibility to infection through cytotoxicity, decreased barrier function, and inflammation. We importantly observed the ability of L. crispatus to largely mitigate these effects and our phenotypic characterization place L. crispatus as the species most adept to provide protection in the FRT. Together, this work contributes to a better understanding of the interactions that govern the dynamics of the VMB and can be built upon to develop more rationale therapeutic or prophylactic interventions to improve the reproductive health of many vulnerable women.

Thesis

Master of Science (MSc)

Advisors/Committee Members: Kaushic, Charu, Medical Sciences.

Subjects/Keywords: Vaginal microbiota

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APA (6^th Edition):

Dupont, H. (2020). Examining abiotic and biotic factors influencing bacterial and host interactions in the female reproductive tract. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/25387

Chicago Manual of Style (16^th Edition):

Dupont, Haley. “Examining abiotic and biotic factors influencing bacterial and host interactions in the female reproductive tract.” 2020. Masters Thesis, McMaster University. Accessed January 23, 2021. http://hdl.handle.net/11375/25387.

MLA Handbook (7^th Edition):

Dupont, Haley. “Examining abiotic and biotic factors influencing bacterial and host interactions in the female reproductive tract.” 2020. Web. 23 Jan 2021.

Vancouver:

Dupont H. Examining abiotic and biotic factors influencing bacterial and host interactions in the female reproductive tract. [Internet] [Masters thesis]. McMaster University; 2020. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/11375/25387.

Council of Science Editors:

Dupont H. Examining abiotic and biotic factors influencing bacterial and host interactions in the female reproductive tract. [Masters Thesis]. McMaster University; 2020. Available from: http://hdl.handle.net/11375/25387

Texas A&M University

4. Whitfield-Cargile, Canaan M. NSAID Enteropathy: Novel Aspects of Pathophysiology, Diagnosis, and Treatment.

Degree: PhD, Biomedical Sciences, 2016, Texas A&M University

URL: http://hdl.handle.net/1969.1/158982

► Although non-steroidal anti-inflammatory drugs (NSAIDs) are among the most frequently used classes of medications in the world, they are well-known to induce an enteropathy that… (more)

▼ Although non-steroidal anti-inflammatory drugs (NSAIDs) are among the most frequently used classes of medications in the world, they are well-known to induce an enteropathy that is associated with high morbidity and mortality in upwards of 70% of users. The diagnosis of NSAID enteropathy is difficult. Furthermore, the underlying mechanisms by which NSAIDs induce enteropathy remain ill-defined although microbiota-host interactions appear to play an important role. Importantly, in addition to difficulty in diagnosing this disease, there are also no effective treatment strategies. Therefore, the purpose of this research was to determine if the microbiota-derived metabolite indole, could attenuate severity of NSAID enteropathy. A second goal was to determine if the transcriptome of exfoliated intestinal epithelial cells (IECs) found in the stool could be reflective of NSAID enteropathy, thereby allowing a non-invasive approach to studying how the mucosal transcriptome is altered by NSAIDs and potentially discriminating between healthy and diseased animals. We utilized a mouse model of NSAID enteropathy, whereby mice were assigned to 1 of 4 groups: 1) NSAID; 2) indole; 3) NSAID + indole; and, 4) untreated controls. Disease severity was determined by a number of assays including: fecal calprotectin, microscopic pathology, neutrophil infiltration, and RNA-seq of the ileal mucosa. Diversity and composition of the fecal microbiota was determined by 16S rRNA sequencing. Non-invasive examination of the mucosal transcriptome was determined by isolation and sequencing of polyA+ RNA from the stool followed by novel computational approaches to assess the inter-relatedness of exfoliated and tissue-level transcriptomes. Results from these assays revealed that indole did in fact attenuate disease severity and this improvement appeared to be related to composition of the microbiota. In addition, approximately 96% of all genes that were mapped from the exfoliated cell RNA were also present in the tissue-level RNA and the pathways represented by these genes and their directional changes were similar in both the small intestinal mucosa and exfoliated IEC transcriptome. These findings demonstrate that the exfoliated cell transcriptome correlates to the tissue-level transcriptome and can be used to gain longitudinal information related to NSAID-induced alterations of the mucosal transcriptome and to discriminate between diseased and healthy animals. Advisors/Committee Members: Cohen, Noah D (advisor), Alaniz, Robert (committee member), Hardy, Joanne (committee member), Lawhon, Sara (committee member), Suchodolski, Jan (committee member).

Subjects/Keywords: enteropathy; microbiota

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APA (6^th Edition):

Whitfield-Cargile, C. M. (2016). NSAID Enteropathy: Novel Aspects of Pathophysiology, Diagnosis, and Treatment. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/158982

Chicago Manual of Style (16^th Edition):

Whitfield-Cargile, Canaan M. “NSAID Enteropathy: Novel Aspects of Pathophysiology, Diagnosis, and Treatment.” 2016. Doctoral Dissertation, Texas A&M University. Accessed January 23, 2021. http://hdl.handle.net/1969.1/158982.

MLA Handbook (7^th Edition):

Whitfield-Cargile, Canaan M. “NSAID Enteropathy: Novel Aspects of Pathophysiology, Diagnosis, and Treatment.” 2016. Web. 23 Jan 2021.

Vancouver:

Whitfield-Cargile CM. NSAID Enteropathy: Novel Aspects of Pathophysiology, Diagnosis, and Treatment. [Internet] [Doctoral dissertation]. Texas A&M University; 2016. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1969.1/158982.

Council of Science Editors:

Whitfield-Cargile CM. NSAID Enteropathy: Novel Aspects of Pathophysiology, Diagnosis, and Treatment. [Doctoral Dissertation]. Texas A&M University; 2016. Available from: http://hdl.handle.net/1969.1/158982

5. Bilen, Melhem. Description of the human gut microbiota by culturomics : Description du microbiote intestinal humain par culturomics.

Degree: Docteur es, Pathologie humaine. Maladies infectieuses, 2018, Aix Marseille Université

URL: http://www.theses.fr/2018AIXM0177

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Le microbiote intestinal humain a été fortement corrélé avec la santé humaine et les maladies et a montré un potentiel dans les développements thérapeutiques. La… (more)

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Le microbiote intestinal humain a été fortement corrélé avec la santé humaine et les maladies et a montré un potentiel dans les développements thérapeutiques. La métagénomique a déjà montré qu'elle était capable de générer beaucoup de données, dont certaines sont dénuées de sens et constituaient la "matière noire". Alors culturomics a été développée pour compléter la métagénomique en ciblant des espèces bactériennes précédemment non cultivées. En utilisant la culturomics, nous avons décrit le microbiote intestinal humain des Pygmées et réussi à isoler un nombre significatif d'espèces bactériennes parmi lesquelles 38 étaient de nouvelles espèces. En comparant les résultats métagénomiques aux données culturomics, on constate que seulement 26% des espèces isolées ont été récupérées par métagénomique et que jusqu'à 59% des Operational taxonomic units détectées correspondaient à de nouvelles espèces bactériennes isolées par culturomique dans cette étude ou dans les précédentes.

The human gut microbiota has been correlated in general health and diseases. Thus its description became mandatory to better understand its role and therapeutic potential. However, metagenomics has previously showed to be able to generate a lot of data, of which some are meaningless and constituted the “Dark matter”. Thus, culturomics was developed to complement metagenomics by targeting previously uncultured bacterial species. Using culturomics, we described the human gut microbiota of Pygmy people and succeeded in isolating a significant number of bacterial species out of which 38 were new species. Comparing metagenomics results to culturomics data, we see that only 26% of the isolated species were recovered by metagenomics and that up to 59% of the Operational taxonomic units detected corresponded to new bacterial species isolated by culturomics either in this study or in previous ones.

Advisors/Committee Members: Raoult, Didier (thesis director), Daoud, Ziad (thesis director).

Subjects/Keywords: Microbiote; Microbiota

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APA (6^th Edition):

Bilen, M. (2018). Description of the human gut microbiota by culturomics : Description du microbiote intestinal humain par culturomics. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2018AIXM0177

Chicago Manual of Style (16^th Edition):

Bilen, Melhem. “Description of the human gut microbiota by culturomics : Description du microbiote intestinal humain par culturomics.” 2018. Doctoral Dissertation, Aix Marseille Université. Accessed January 23, 2021. http://www.theses.fr/2018AIXM0177.

MLA Handbook (7^th Edition):

Bilen, Melhem. “Description of the human gut microbiota by culturomics : Description du microbiote intestinal humain par culturomics.” 2018. Web. 23 Jan 2021.

Vancouver:

Bilen M. Description of the human gut microbiota by culturomics : Description du microbiote intestinal humain par culturomics. [Internet] [Doctoral dissertation]. Aix Marseille Université 2018. [cited 2021 Jan 23]. Available from: http://www.theses.fr/2018AIXM0177.

Council of Science Editors:

Bilen M. Description of the human gut microbiota by culturomics : Description du microbiote intestinal humain par culturomics. [Doctoral Dissertation]. Aix Marseille Université 2018. Available from: http://www.theses.fr/2018AIXM0177

University of Manitoba

6. Priyantha, Wengappuliarachchi. Infant gut microbiota changes during lactation and how it is shaped by human breast milk microbiota.

Degree: Human Nutritional Sciences, University of Manitoba

URL: http://hdl.handle.net/1993/30840

► Background: Human breast milk is a primary source of bacteria for the infant gut. This study aims to develop bacterial DNA extraction methods to determine… (more)

Subjects/Keywords: Microbiota

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APA (6^th Edition):

Priyantha, W. (n.d.). Infant gut microbiota changes during lactation and how it is shaped by human breast milk microbiota. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/30840

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Chicago Manual of Style (16^th Edition):

Priyantha, Wengappuliarachchi. “Infant gut microbiota changes during lactation and how it is shaped by human breast milk microbiota.” Masters Thesis, University of Manitoba. Accessed January 23, 2021. http://hdl.handle.net/1993/30840.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

MLA Handbook (7^th Edition):

Priyantha, Wengappuliarachchi. “Infant gut microbiota changes during lactation and how it is shaped by human breast milk microbiota.” Web. 23 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Priyantha W. Infant gut microbiota changes during lactation and how it is shaped by human breast milk microbiota. [Internet] [Masters thesis]. University of Manitoba; [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1993/30840.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Council of Science Editors:

Priyantha W. Infant gut microbiota changes during lactation and how it is shaped by human breast milk microbiota. [Masters Thesis]. University of Manitoba; Available from: http://hdl.handle.net/1993/30840

Note: this citation may be lacking information needed for this citation format:
No year of publication.

7. Bergentall, Mattias. On the role of gut microbiota in intestinal physiology and hepatic metabolism.

Degree: 2017, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/50862

► The gut microbiota, a complex and dynamic community of microbes in the mammalian gut, has coevolved with us for ample time providing mutual benefits. However,… (more)

▼ The gut microbiota, a complex and dynamic community of microbes in the mammalian gut, has coevolved with us for ample time providing mutual benefits. However, mechanistic knowledge of these has been limited, but are now becoming increasingly clear. We used germ-free mice to study three aspects of host physiology; the effects of the microbiota on small intestinal postnatal vascularization (I), small intestinal permeability (II), as well as the interplay between the gut microbiota and a steatogenic diet and the subsequent effects on hepatic metabolism (III). In Paper I we found a new mechanism underlying microbiota-induced vascular remodeling in the small intestinal villi. This mechanism involves activation of protease activated receptor-1(PAR1) induced by microbial regulation of tissue factor activity. As a consequence of PAR1 signaling we observe increased angiopoietin expression in the intestinal epithelium and subsequent expansion of blood vasculature. In Paper II we applied Ussing chambers to determine small intestinal permeability and observed increased permeability in conventionally raised (CONV-R) mice, compared with germ-free (GF) mice. This was accompanied by reduced mRNA expression of tight junction proteins and ultrastructure analyses revealed wider tight junctions and reduced numbers of desmosomes. The alterations between GF and CONV-R mice were abolished in the absence of farnesoid X receptor. In Paper III we investigated if the gut microbiota interacted with dietary sucrose to induce hepatic steatosis. GF and CONV-R mice were fed a zero-fat, high-sucrose diet (ZFD) or control diet and we observed a synergistic effect of diet and microbiota on hepatic steatosis by induction of de novo lipogenesis. Furthermore, we could establish a central role for the transcription factor sterol regulatory element-binding protein-1c (SREBP-1c) in this process. In conclusion, these studies show that the microbiota induces expansion of intestinal vasculature and increased permeability, which may both contribute to metabolic effects. Further, the microbiota is required for a zero-fat, high sucrose diet to be steatogenic. This could give rise to novel treatment options for non-alcoholic fatty liver disease. Keywords: Gut microbiota, Intestinal permeability, Non-alcoholic fatty liver disease ISBN: 978-91-629-0121-9 (TRYCK) ISBN: 978-91-628-0122-6 (PDF)

Subjects/Keywords: microbiota; metabolism

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APA (6^th Edition):

Bergentall, M. (2017). On the role of gut microbiota in intestinal physiology and hepatic metabolism. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/50862

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bergentall, Mattias. “On the role of gut microbiota in intestinal physiology and hepatic metabolism.” 2017. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed January 23, 2021. http://hdl.handle.net/2077/50862.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bergentall, Mattias. “On the role of gut microbiota in intestinal physiology and hepatic metabolism.” 2017. Web. 23 Jan 2021.

Vancouver:

Bergentall M. On the role of gut microbiota in intestinal physiology and hepatic metabolism. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2017. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/2077/50862.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bergentall M. On the role of gut microbiota in intestinal physiology and hepatic metabolism. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2017. Available from: http://hdl.handle.net/2077/50862

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University College Cork

8. O'Connor, Karen M. Bugs, breathing and blood pressure: the microbiota-gut-brain axis in cardiorespiratory control.

Degree: 2019, University College Cork

URL: http://hdl.handle.net/10468/9476

► Dysregulated microbiota-gut-brain axis communication adversely influences neurocontrol systems, consequently affecting brain behaviours. It is plausible that microbiota-gut-brain axis signalling has a role in the control… (more)

▼ Dysregulated microbiota-gut-brain axis communication adversely influences neurocontrol systems, consequently affecting brain behaviours. It is plausible that microbiota-gut-brain axis signalling has a role in the control of breathing and cardiovascular function, as networks that govern cardiorespiratory control reside within the brainstem, a region innervated by the vagus nerve, a key signalling pathway of the microbiota-gut-brain axis. Cardiovascular and respiratory diseases are serious, potentially life-threatening conditions with limited treatment options. Thus, improved understanding of the underlying pathophysiology and novel therapeutic approaches are required. We performed an assessment of cardiorespiratory physiology in animal models of modified gut microbiota [antibiotic-treated (ABX) and faecal microbiota transfer (FMT)], and sleep-disordered breathing [chronic intermittent hypoxia (CIH)-exposed guinea-pigs and rats]. We investigated if dietary prebiotic supplementation prevented CIH-induced cardiorespiratory dysfunction in rats. Whole-body plethysmography was used to record ventilation and metabolism in unanaesthetised animals during normoxia and chemostimulation. Under anaesthesia, cardiorespiratory assessments were performed during normoxia, chemosensory stimulation and drug administration. Brainstem neurochemistry was assessed by high-performance liquid chromatography. 16S rRNA and whole-metagenome shotgun sequencing was used to characterise the gut microbiota. ABX and FMT disrupted the gut microbiota, brain neurochemistry and intestinal integrity, blunting chemoreflex control of breathing. Decreased brainstem noradrenaline and altered gut microbiota as well as impaired respiratory and autonomic control were evident in CIH-exposed guinea-pigs. CIH–exposed rats developed cardiorespiratory pathologies and decreased gut Lactobacillus rhamnosus relative abundance. Prebiotic administration increased short-chain fatty acid concentrations, measured by gas chromatography, but Lactobacillus rhamnosus and cardiorespiratory dysfunctions were not restored. Several commensal and pathogenic bacterial species correlated with blood pressure parameters. Our findings add to emerging research exploring microbiota-gut-brain signalling in homeostatic systems, extending investigations to cardiorespiratory control. Our studies draw focus to the potential application of manipulation of the gut microbiota as an adjunctive therapy for cardiorespiratory disease. Advisors/Committee Members: O'Halloran, Ken D., Cryan, John, SFI.

Subjects/Keywords: Cardiorespiratory; Microbiota

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APA (6^th Edition):

O'Connor, K. M. (2019). Bugs, breathing and blood pressure: the microbiota-gut-brain axis in cardiorespiratory control. (Thesis). University College Cork. Retrieved from http://hdl.handle.net/10468/9476

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

O'Connor, Karen M. “Bugs, breathing and blood pressure: the microbiota-gut-brain axis in cardiorespiratory control.” 2019. Thesis, University College Cork. Accessed January 23, 2021. http://hdl.handle.net/10468/9476.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

O'Connor, Karen M. “Bugs, breathing and blood pressure: the microbiota-gut-brain axis in cardiorespiratory control.” 2019. Web. 23 Jan 2021.

Vancouver:

O'Connor KM. Bugs, breathing and blood pressure: the microbiota-gut-brain axis in cardiorespiratory control. [Internet] [Thesis]. University College Cork; 2019. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10468/9476.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

O'Connor KM. Bugs, breathing and blood pressure: the microbiota-gut-brain axis in cardiorespiratory control. [Thesis]. University College Cork; 2019. Available from: http://hdl.handle.net/10468/9476

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

9. Torrijo Bueno, Beatriz. Influencia de la microbiota en pacientes con trastornos del comportamiento.

Degree: Máster en Condicionantes Genéticos, Nutricionales y Ambientales del Crecimiento y el Desarrollo, 2017, Universidad de Cantabria

URL: http://hdl.handle.net/10902/12432

► Los estudios metabólicos en pacientes pediátricos con trastornos del comportamiento, habitualmente muestran alteraciones significativas en los patrones de ácidos orgánicos urinarios debidos a la presencia… (more)

Subjects/Keywords: Microbiota

…función del eje intestino-cerebro de la microbiota. Trastornos del control neurológico en… …la microbiota intestinal sobre el comportamiento también puede explicarse tanto por vías… …el sistema central de respuesta al estrés y afecta a la microbiota intestinal y viceversa… …microbiota intestinal también juega un papel importante en la modulación tanto del sistema inmune… …sistémicos de citoquinas, es posible que la microbiota implemente su efecto sobre el comportamiento…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Torrijo Bueno, B. (2017). Influencia de la microbiota en pacientes con trastornos del comportamiento. (Masters Thesis). Universidad de Cantabria. Retrieved from http://hdl.handle.net/10902/12432

Chicago Manual of Style (16^th Edition):

Torrijo Bueno, Beatriz. “Influencia de la microbiota en pacientes con trastornos del comportamiento.” 2017. Masters Thesis, Universidad de Cantabria. Accessed January 23, 2021. http://hdl.handle.net/10902/12432.

MLA Handbook (7^th Edition):

Torrijo Bueno, Beatriz. “Influencia de la microbiota en pacientes con trastornos del comportamiento.” 2017. Web. 23 Jan 2021.

Vancouver:

Torrijo Bueno B. Influencia de la microbiota en pacientes con trastornos del comportamiento. [Internet] [Masters thesis]. Universidad de Cantabria; 2017. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10902/12432.

Council of Science Editors:

Torrijo Bueno B. Influencia de la microbiota en pacientes con trastornos del comportamiento. [Masters Thesis]. Universidad de Cantabria; 2017. Available from: http://hdl.handle.net/10902/12432

Universitat Politècnica de València

10. Santacruz López, Yolanda Arlette. Influencia de la microbiota intestinal en la obesidad .

Degree: 2012, Universitat Politècnica de València

URL: http://hdl.handle.net/10251/16927

► La prevalencia de la obesidad es cada vez mayor y especialmente en niños y adolescentes. En el desarrollo de la obesidad interviene la dieta, factores… (more)

▼ La prevalencia de la obesidad es cada vez mayor y especialmente en niños y adolescentes. En el desarrollo de la obesidad interviene la dieta, factores genéticos, endócrinos, psicológicos y ambientales. El primer objetivo específico fue determinar la influencia de una intervención para el tratamiento de la obesidad sobre la microbiota intestinal de adolescentes obesos y con sobrepeso. Mediante las técnicas de la reacción en cadena de la polimerasa a tiempo real (q-PCR) y de hibridación con fluorescencia in situ (FISH) se cuantificaron los principales grupos bacterianos del tracto intestinal. Los adolescentes que experimentaron mayor perdida de peso, presentaron mayor cantidad de bacterias de los grupos Bacteroides fragilis, Clostridium leptum, Bifidobacterium catenulatum, Lactobacillus, y menor de los grupos y especies de Bifidobacterium, Lactobacillus, Clostridium coccoides, B. breve y B.bifidum, antes y después de la intervención con respecto al grupo de menor pérdida de peso. El segundo objetivo fue evaluar la microbiota intestinal de mujeres embarazadas con sobrepeso debido a que su microbiota influye en la microbiota del hijo. Con el análisis de la microbiota por qPCR y de parámetros bioquímicos se obtuvo que las mujeres con sobrepeso presentaron menor cantidad de Bifidobacterias y Bacteroides, y mayor cantidad de Staphylococcus, Enterobacterias y E.coli. que en el grupo normopeso. El número de Staphylococcus presentó una correlación positiva con el colesterol total, Bacteroides positiva con el colesterol HDL y con el ácido fólico, y negativa con los triglicéridos, el número de Bifidobacteriums presentó una correlación positiva con el ácido fólico, y los de Enterobacteriaceae y E.coli presentaron una correlación positiva con ferritina y negativa con transferrina. Por todo ello se puede decir, que la microbiota intestinal esta relacionada con el peso corporal, con la ganancia de peso y los parámetros metabólicos durante el embarazo, lo cual puede ser Advisors/Committee Members: Sanz Herranz, Mª Yolanda (advisor).

Subjects/Keywords: Microbiota; Obesidad

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Santacruz López, Y. A. (2012). Influencia de la microbiota intestinal en la obesidad . (Doctoral Dissertation). Universitat Politècnica de València. Retrieved from http://hdl.handle.net/10251/16927

Chicago Manual of Style (16^th Edition):

Santacruz López, Yolanda Arlette. “Influencia de la microbiota intestinal en la obesidad .” 2012. Doctoral Dissertation, Universitat Politècnica de València. Accessed January 23, 2021. http://hdl.handle.net/10251/16927.

MLA Handbook (7^th Edition):

Santacruz López, Yolanda Arlette. “Influencia de la microbiota intestinal en la obesidad .” 2012. Web. 23 Jan 2021.

Vancouver:

Santacruz López YA. Influencia de la microbiota intestinal en la obesidad . [Internet] [Doctoral dissertation]. Universitat Politècnica de València; 2012. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10251/16927.

Council of Science Editors:

Santacruz López YA. Influencia de la microbiota intestinal en la obesidad . [Doctoral Dissertation]. Universitat Politècnica de València; 2012. Available from: http://hdl.handle.net/10251/16927

University of Namibia

11. Angula, Maria A. Identification and characterization of beneficial microbiota in beef biltong from Namibia Central regions .

Degree: 2017, University of Namibia

URL: http://hdl.handle.net/11070/1945

► Microbiota associated with beef biltong has not been assessed in Namibia and there is limited data in the literature describing the presence and role of… (more)

▼ Microbiota associated with beef biltong has not been assessed in Namibia and there is limited data in the literature describing the presence and role of lactic acid bacteria (LAB) in biltong products which is involved in the transformation of many aroma and flavour compounds and therefore, the quality of the final product. The aims of this study were to document the steps involved in beef biltong production, determine the physicochemical parameters that may influence microbial growth, characterize and identify LAB, yeast and moulds associated with beef biltong and, profiling LAB isolates for enzymatic and bacteriocin activities. Beef biltong is produced by a dry curing process. Its average pH ranged from 5.1±0.15 to 5.98±0.16, average sodium chloride content ranged from 3.16±0.62 to 3.98±0.86 g/100g, the average moisture content ranged from 7.56±7.56% to 18.86±8.96% and average water activity (aw) ranged from 0.79±0.05 to 0.84±0.06. Beef biltong samples from Otjozondjupa, Omaheke and Khomas regions were characterized with an average total plate count ranging from 5.4±0.36 to 6.46±0.36 log CFU/g, average total LAB ranging from 5.66±0.41 to 7.02±0.35 log CFU/g while average total yeast and moulds ranged from 5.25±0.78 to 6.14±0.14 log CFU/g. Yeasts associated with beef biltong were identified as Candida zeylanoides, C. guilliermondii, C. famata, C. krusei, C. tropicalis, Meyerozyma guiliermondii and Yarrowia lipolytica using API 20 C AUX and sequencing of the 26S rRNA and ITS genes. The LAB were identified using API 50CHL and sequencing of the 16S rRNA as: Lactobacillus brevis, L. graminis, L. plantarum, L. pentosus, L. paraplantarum, Lactococcus lactis ssp. lactis, Leuconostoc mesenteroides ssp. mesenteroides, Pediococcus acidilactici, P. pentosaceus, Weisella cibaria, and W. confusa, The cell free supernatant (CFS) of LAB was found to exhibit a variable degree of antimicrobial activity by agar well diffusion method against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Clostridium perfringens, Candida albicans and Aspergillus niger. After pH neutralization of the CFS, the antimicrobial activity due to bacteriocin or bacteriocin-like substances was detected in L. plantarum against B. subtilis, C. albicans and A. niger. Enzymatic activities detected in LAB using API ZYM included esterase, lipase, valine arylamidase, cysteine arylamidase, acid phosphatase, leucine arylamidase and β galactosidase. Beef biltong samples were associated with beneficial yeast with applications in food industries, as well as LAB with biotechnological properties such as enzymatic activity and bacteriocin production. Therefore, these strains may be important to be used as starter cultures to improve the quality and safety of meat products.

Subjects/Keywords: Microbiota ; Beef biltong

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Angula, M. A. (2017). Identification and characterization of beneficial microbiota in beef biltong from Namibia Central regions . (Thesis). University of Namibia. Retrieved from http://hdl.handle.net/11070/1945

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Angula, Maria A. “Identification and characterization of beneficial microbiota in beef biltong from Namibia Central regions .” 2017. Thesis, University of Namibia. Accessed January 23, 2021. http://hdl.handle.net/11070/1945.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Angula, Maria A. “Identification and characterization of beneficial microbiota in beef biltong from Namibia Central regions .” 2017. Web. 23 Jan 2021.

Vancouver:

Angula MA. Identification and characterization of beneficial microbiota in beef biltong from Namibia Central regions . [Internet] [Thesis]. University of Namibia; 2017. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/11070/1945.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Angula MA. Identification and characterization of beneficial microbiota in beef biltong from Namibia Central regions . [Thesis]. University of Namibia; 2017. Available from: http://hdl.handle.net/11070/1945

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University College Cork

12. Clarke, Siobhan F. The impact of a variety of factors on the obesity associated gut microbiota.

Degree: 2013, University College Cork

URL: http://hdl.handle.net/10468/1554

► The obesity pandemic has become perhaps the most prevalent health issue of our time, with more than 10% of the world’s population now being obese.… (more)

Subjects/Keywords: Obesity; Gut microbiota

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APA (6^th Edition):

Clarke, S. F. (2013). The impact of a variety of factors on the obesity associated gut microbiota. (Thesis). University College Cork. Retrieved from http://hdl.handle.net/10468/1554

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Clarke, Siobhan F. “The impact of a variety of factors on the obesity associated gut microbiota.” 2013. Thesis, University College Cork. Accessed January 23, 2021. http://hdl.handle.net/10468/1554.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Clarke, Siobhan F. “The impact of a variety of factors on the obesity associated gut microbiota.” 2013. Web. 23 Jan 2021.

Vancouver:

Clarke SF. The impact of a variety of factors on the obesity associated gut microbiota. [Internet] [Thesis]. University College Cork; 2013. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10468/1554.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Clarke SF. The impact of a variety of factors on the obesity associated gut microbiota. [Thesis]. University College Cork; 2013. Available from: http://hdl.handle.net/10468/1554

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Urbana-Champaign

13. Harold, Kirsten Berding. Nutrition and the GI microbiota in children with autism spectrum disorder and impact on symptom severity.

Degree: PhD, Nutritional Sciences, 2018, University of Illinois – Urbana-Champaign

URL: http://hdl.handle.net/2142/101801

► The gastrointestinal (GI) microbiota is increasingly recognized for its ability to influence brain function and behavior. In children with Autism Spectrum Disorder (ASD), a microbial… (more)

▼ The gastrointestinal (GI) microbiota is increasingly recognized for its ability to influence brain function and behavior. In children with Autism Spectrum Disorder (ASD), a microbial dysbiosis has been described and some bacterial taxa were found to predict certain symptoms of ASD. Additionally, picky eating behavior and food aversions are common in children with ASD, resulting in limited diet variety and decreased nutrient intake (e.g., fiber). Diet is one of the major determinants of the GI microbiota; however, previous studies have not systematically investigated the role of diet in shaping the GI microbiota in children with ASD. Likewise, overall microbial stability is recognized as more beneficial due to its ability to protect against pathogen invasion and maintain overall function. In children with ASD little is known about the stability of the microbiota. Therefore, the goal this dissertation research was to assess the impact of diet on the GI microbiota in children with ASD and microbial stability over a 6-month period with the following aims :1) to investigate differences in microbiota composition and volatile fatty acid (VFA) concentration between children with ASD and unaffected controls and investigate the relationship to ASD symptoms; 2) to determine the effect of long-term dietary patterns and short-term nutrient intake on the fecal microbial composition and VFA concentration in children with ASD and uncover relationships between diet, fecal microbiota, VFAs and ASD symptoms; and 3) to analyze the microbiota composition and VFA concentrations in children with ASD and unaffected controls over a 6-month period and identify dietary factors that correlate with a more stable microbial profile. Children with ASD (ASD; n=26) and age- and sex-matched unaffected controls (CONT; n=32) were recruited in the Midwest area. Fecal samples, a 3-day food diary, a food frequency questionnaire, and an online questionnaire collecting information on demographics, GI health, nutrition supplement use were collected at baseline, 6-weeks post-baseline and 6-months post baseline. ASD symptoms were assessed using the Pervasive Developmental Disorder Behavior Inventory – Screening Version (PDDBI-SV). Bacterial DNA was analyzed using 16S rRNA sequencing and quantitative Polymerase Chain Reaction. VFA concentrations were analyzed by gas chromatography. Dietary patterns were derived from the Youth and Adolescence Food Frequency Questionnaire (YAQ) using Principal Component Analysis and exploratory Factor Analysis. Nutrient intake was assessed by the Nutrition Data System for Research. All data were analyzed using SAS 9.4. Differences in microbiota composition between ASD and CONT were observed. Overall, β-diversity assessed by permutational multivariate analysis (PERMANOVA) differed (p=0.02) based on unweighted but not weighted d UniFrac. α-diversity measured as observed Operational Taxonomic Units (OTUs) tended to be higher (p=0.08) in ASD. Microbial abundances on the phyla, family, order and genera level were observed. Namely,… Advisors/Committee Members: Donovan, Sharon M. (advisor), Dilger, Ryan N. (Committee Chair), Miller, Michael J. (committee member), Holscher, Hannah D. (committee member), Cohen, Amy P (committee member).

Subjects/Keywords: ASD; Microbiota; Nutrition

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Harold, K. B. (2018). Nutrition and the GI microbiota in children with autism spectrum disorder and impact on symptom severity. (Doctoral Dissertation). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/101801

Chicago Manual of Style (16^th Edition):

Harold, Kirsten Berding. “Nutrition and the GI microbiota in children with autism spectrum disorder and impact on symptom severity.” 2018. Doctoral Dissertation, University of Illinois – Urbana-Champaign. Accessed January 23, 2021. http://hdl.handle.net/2142/101801.

MLA Handbook (7^th Edition):

Harold, Kirsten Berding. “Nutrition and the GI microbiota in children with autism spectrum disorder and impact on symptom severity.” 2018. Web. 23 Jan 2021.

Vancouver:

Harold KB. Nutrition and the GI microbiota in children with autism spectrum disorder and impact on symptom severity. [Internet] [Doctoral dissertation]. University of Illinois – Urbana-Champaign; 2018. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/2142/101801.

Council of Science Editors:

Harold KB. Nutrition and the GI microbiota in children with autism spectrum disorder and impact on symptom severity. [Doctoral Dissertation]. University of Illinois – Urbana-Champaign; 2018. Available from: http://hdl.handle.net/2142/101801

University of Oregon

14. Schlomann, Brandon. Learning Biophysical Rules of Gut Bacterial Communities Through Live Imaging of Zebrafish.

Degree: PhD, Department of Physics, 2020, University of Oregon

URL: https://scholarsbank.uoregon.edu/xmlui/handle/1794/25611

► Vast communities of microorganisms inhabit the gastrointestinal tracts of humans and other animals, where they influence diverse aspects of animal health and disease. Our understanding… (more)

▼ Vast communities of microorganisms inhabit the gastrointestinal tracts of humans and other animals, where they influence diverse aspects of animal health and disease. Our understanding of the types of microbes present in the intestine and the genes that they carry has grown tremendously in recent years, but despite this progress, we are still unable to predict the abundances of microbial strains in the gut and their impact on host phenotypes. This deficiency limits our abilities to uncover causal mechanisms mediating host-microbe interactions and to rationally design novel therapeutic strategies. A major barrier to achieving these goals is our limited ability to experimentally probe the spatial organization of gut bacterial communities, which is thought to be a key driver of microbiota dynamics, but which is largely inaccessible in most systems. This dissertation work addresses these knowledge gaps by combining quantitative theory with controlled experiments in a model system that can uniquely surmount these technical challenges. The larval zebrafish is an optically transparent, model vertebrate that is amenable to live imaging studies, in which bacteria in the gut can be directly visualized and studied in situ. Through this approach, we discovered that the biophysical properties of bacteria in the gut, especially their aggregation and swimming behaviors, coupled to intestinal fluid flows, determine in robust but probabilistic ways several large-scale features of whole bacterial populations. These features include global spatial distributions of bacteria throughout the gut, bacterial population dynamics, both at baseline and in response to perturbations like antibiotics, and the ability of bacteria to stimulate immune responses. Through the study and validation of phenomenological models, we argue that these effects are generic and manifest in other animals, including humans, and suggest new strategies to harness these effects for precision microbiome engineering. Advisors/Committee Members: Parthasarathy, Raghuveer (advisor).

Subjects/Keywords: bacteria; microbiota; zebrafish

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APA (6^th Edition):

Schlomann, B. (2020). Learning Biophysical Rules of Gut Bacterial Communities Through Live Imaging of Zebrafish. (Doctoral Dissertation). University of Oregon. Retrieved from https://scholarsbank.uoregon.edu/xmlui/handle/1794/25611

Chicago Manual of Style (16^th Edition):

Schlomann, Brandon. “Learning Biophysical Rules of Gut Bacterial Communities Through Live Imaging of Zebrafish.” 2020. Doctoral Dissertation, University of Oregon. Accessed January 23, 2021. https://scholarsbank.uoregon.edu/xmlui/handle/1794/25611.

MLA Handbook (7^th Edition):

Schlomann, Brandon. “Learning Biophysical Rules of Gut Bacterial Communities Through Live Imaging of Zebrafish.” 2020. Web. 23 Jan 2021.

Vancouver:

Schlomann B. Learning Biophysical Rules of Gut Bacterial Communities Through Live Imaging of Zebrafish. [Internet] [Doctoral dissertation]. University of Oregon; 2020. [cited 2021 Jan 23]. Available from: https://scholarsbank.uoregon.edu/xmlui/handle/1794/25611.

Council of Science Editors:

Schlomann B. Learning Biophysical Rules of Gut Bacterial Communities Through Live Imaging of Zebrafish. [Doctoral Dissertation]. University of Oregon; 2020. Available from: https://scholarsbank.uoregon.edu/xmlui/handle/1794/25611

15. Douvropoulou, Olga. Interactions between Cryptosporidium parvum and the Intestinal Ecosystem.

Degree: 2017, King Abdullah University of Science and Technology

URL: http://hdl.handle.net/10754/623721

► Cryptosporidium parvum is an apicomplexan protozoan parasite commonly causing diarrhea, particularly in infants in developing countries. The research challenges faced in the development of therapies… (more)

Subjects/Keywords: Cryptosporidium; microbiota; dysbiosis

10 more images…

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APA (6^th Edition):

Douvropoulou, O. (2017). Interactions between Cryptosporidium parvum and the Intestinal Ecosystem. (Thesis). King Abdullah University of Science and Technology. Retrieved from http://hdl.handle.net/10754/623721

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Douvropoulou, Olga. “Interactions between Cryptosporidium parvum and the Intestinal Ecosystem.” 2017. Thesis, King Abdullah University of Science and Technology. Accessed January 23, 2021. http://hdl.handle.net/10754/623721.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Douvropoulou, Olga. “Interactions between Cryptosporidium parvum and the Intestinal Ecosystem.” 2017. Web. 23 Jan 2021.

Vancouver:

Douvropoulou O. Interactions between Cryptosporidium parvum and the Intestinal Ecosystem. [Internet] [Thesis]. King Abdullah University of Science and Technology; 2017. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10754/623721.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Douvropoulou O. Interactions between Cryptosporidium parvum and the Intestinal Ecosystem. [Thesis]. King Abdullah University of Science and Technology; 2017. Available from: http://hdl.handle.net/10754/623721

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Sul

16. Zanelatto, Carla. Ecologia de leveduras da cavidade bucal de pessoas saudáveis : diversidade de espécies e distribuição espacial.

Degree: 2015, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/129953

►

Para melhor compreender o papel dos micro-organismos nas doenças da cavidade bucal, é necessário inicialmente avaliar a diversidade microbiana naturalmente existente em indivíduos saudáveis, além… (more)

▼

Para melhor compreender o papel dos micro-organismos nas doenças da cavidade bucal, é necessário inicialmente avaliar a diversidade microbiana naturalmente existente em indivíduos saudáveis, além de sua distribuição espacial na cavidade bucal. Muitos estudos são conduzidos elucidando o papel do biofilme e das bactérias na saúde bucal, porém poucas pesquisas focaram na atuação das leveduras. Neste sentido, o objetivo do presente trabalho foi avaliar a diversidade e distribuição de leveduras do gênero Candida na microbiota bucal de indivíduos saudáveis. Foram coletadas amostras da boca pacientes adultos saudáveis. Foram obtidas amostras de 9 diferentes habitats da boca: bochechas direita e esquerda, assoalho da boca, palato, língua dorsal, língua ventral, dente molar, vestíbulo labial e saliva. Foram avaliados 100 pacientes com uma média de 28 dentes. Quarenta e nove indivíduos apresentaram leveduras na sua microbiota bucal. Candida albicans foi o micro-organismo mais prevalente (49%), seguido de Candida krusei, Candida parapsilosis, Meyerozyma guilliermondii (C. guilliermondii), Candida glabrata, Candida tropicalis e Candida dubliniensis. A associação das leveduras encontradas e os habitats bucais sugeriu que comunidades leveduriformes podem distinguir-se entre os diferentes tecidos da cavidade bucal. A língua (dorsal e ventral) apresentou colonização específica, caracterizada pelas espécies C. tropicalis e C. dubliniensis. De forma semelhante, a microbiota dos habitats revestidos por mucosa foi análoga. A microbiota da língua e dos tecidos duros assemelhou-se entre si em menor intensidade. Estes resultados introduzem a dimensão espacial desta diversidade microbiana que vem sendo estudada, complementando as informações obtidas nos estudos do microbioma humano.

To better understand the role of microorganisms in the diseases of the oral cavity, first it is necessary to evaluate the natural microbial diversity in healthy individuals, as well as their spatial distribution in the oral cavity. Many studies are conducted elucidating the role of biofilms and bacteria in oral health, but few research has focused on the yeast’s performance. In this sense, the objective of this study was to evaluate the diversity and distribution of Candida species in the oral microbiota of healthy individuals. Samples were colleted from the mouth of healthy adults. Samples of 9 different mouth habitats were obtained: right and left cheeks, floor of the mouth, palate, dorsal tongue, ventral tongue, molar tooth, labial vestibule and saliva. We evaluated 100 patients with an average of 28 teeth. Forty-nine subjects had yeasts in their oral microbiota. Candida albicans was the most prevalent microorganism (49%), followed by Candida krusei, Candida parapsilosis, Meyerozyma guilliermondii (C. guilliermondii), Candida glabrata, Candida tropicalis and Candida dubliniensis. The association found between the yeasts and oral habitats suggested that communities can be distinguished by the different tissues of the oral cavity. The tongue (dorsal and…

Advisors/Committee Members: Silva, Patrícia Valente da.

Subjects/Keywords: Leveduras; Boca; Candida; Microbiota; Fungos

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APA (6^th Edition):

Zanelatto, C. (2015). Ecologia de leveduras da cavidade bucal de pessoas saudáveis : diversidade de espécies e distribuição espacial. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/129953

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zanelatto, Carla. “Ecologia de leveduras da cavidade bucal de pessoas saudáveis : diversidade de espécies e distribuição espacial.” 2015. Thesis, Universidade do Rio Grande do Sul. Accessed January 23, 2021. http://hdl.handle.net/10183/129953.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zanelatto, Carla. “Ecologia de leveduras da cavidade bucal de pessoas saudáveis : diversidade de espécies e distribuição espacial.” 2015. Web. 23 Jan 2021.

Vancouver:

Zanelatto C. Ecologia de leveduras da cavidade bucal de pessoas saudáveis : diversidade de espécies e distribuição espacial. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2015. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10183/129953.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zanelatto C. Ecologia de leveduras da cavidade bucal de pessoas saudáveis : diversidade de espécies e distribuição espacial. [Thesis]. Universidade do Rio Grande do Sul; 2015. Available from: http://hdl.handle.net/10183/129953

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universiteit Utrecht

17. Giannakou, C. The Effect Of Probiotic Administration On The Risk Of Atopic Sensitization And Asthma induction In Children And Adults.

Degree: 2014, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/297815

► Nowadays, atopic diseases and allergic asthma show high rates within the population and especially children. The underlying mechanisms of these diseases’ induction, as unraveled up-to-date,… (more)

Subjects/Keywords: probiotics; asthma; microbiota; atopic diseases

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APA (6^th Edition):

Giannakou, C. (2014). The Effect Of Probiotic Administration On The Risk Of Atopic Sensitization And Asthma induction In Children And Adults. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/297815

Chicago Manual of Style (16^th Edition):

Giannakou, C. “The Effect Of Probiotic Administration On The Risk Of Atopic Sensitization And Asthma induction In Children And Adults.” 2014. Masters Thesis, Universiteit Utrecht. Accessed January 23, 2021. http://dspace.library.uu.nl:8080/handle/1874/297815.

MLA Handbook (7^th Edition):

Giannakou, C. “The Effect Of Probiotic Administration On The Risk Of Atopic Sensitization And Asthma induction In Children And Adults.” 2014. Web. 23 Jan 2021.

Vancouver:

Giannakou C. The Effect Of Probiotic Administration On The Risk Of Atopic Sensitization And Asthma induction In Children And Adults. [Internet] [Masters thesis]. Universiteit Utrecht; 2014. [cited 2021 Jan 23]. Available from: http://dspace.library.uu.nl:8080/handle/1874/297815.

Council of Science Editors:

Giannakou C. The Effect Of Probiotic Administration On The Risk Of Atopic Sensitization And Asthma induction In Children And Adults. [Masters Thesis]. Universiteit Utrecht; 2014. Available from: http://dspace.library.uu.nl:8080/handle/1874/297815

18. SILVA, Tatiana Maria da. Caracterização da microbiota bacteriana de Biomphalaria glabrata (Say, 1818)(Mollusca: Gastropoda) .

Degree: 2012, Universidade Federal de Pernambuco

URL: http://repositorio.ufpe.br/handle/123456789/11142

► Devido a grande importância da microbiota no desenvolvimento de parasitas nos invertebrados, muitos estudos vêm sendo desenvolvidos para o melhor entendimento desta interação. Desta forma,… (more)

Subjects/Keywords: Biomphalaria glabrata; Microbiota; Antimicrobianos

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APA (6^th Edition):

SILVA, T. M. d. (2012). Caracterização da microbiota bacteriana de Biomphalaria glabrata (Say, 1818)(Mollusca: Gastropoda) . (Thesis). Universidade Federal de Pernambuco. Retrieved from http://repositorio.ufpe.br/handle/123456789/11142

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

SILVA, Tatiana Maria da. “Caracterização da microbiota bacteriana de Biomphalaria glabrata (Say, 1818)(Mollusca: Gastropoda) .” 2012. Thesis, Universidade Federal de Pernambuco. Accessed January 23, 2021. http://repositorio.ufpe.br/handle/123456789/11142.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

SILVA, Tatiana Maria da. “Caracterização da microbiota bacteriana de Biomphalaria glabrata (Say, 1818)(Mollusca: Gastropoda) .” 2012. Web. 23 Jan 2021.

Vancouver:

SILVA TMd. Caracterização da microbiota bacteriana de Biomphalaria glabrata (Say, 1818)(Mollusca: Gastropoda) . [Internet] [Thesis]. Universidade Federal de Pernambuco; 2012. [cited 2021 Jan 23]. Available from: http://repositorio.ufpe.br/handle/123456789/11142.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

SILVA TMd. Caracterização da microbiota bacteriana de Biomphalaria glabrata (Say, 1818)(Mollusca: Gastropoda) . [Thesis]. Universidade Federal de Pernambuco; 2012. Available from: http://repositorio.ufpe.br/handle/123456789/11142

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

19. Cavalli, Daiana [UNESP]. Estudo comparativo de sistemas rotatório, reciprocante e híbrido no preparo de canais radiculares em dentes com infecção endodôntica primária: perfil microbiano e quantificação de endotoxinas.

Degree: 2017, Universidade Estadual Paulista

URL: http://hdl.handle.net/11449/148838

► Os objetivos deste trabalho são: 1) Quantificar por checkerboard a carga microbiana e pelo método de LAL endotoxinas (EU/mL) nas infecções endodônticas primárias; 2) Realizar… (more)

▼ Os objetivos deste trabalho são: 1) Quantificar por checkerboard a carga microbiana e pelo método de LAL endotoxinas (EU/mL) nas infecções endodônticas primárias; 2) Realizar o monitoramento dos níveis de endotoxinas (EU/mL) e de carga microbiana antes do tratamento, após o preparo biomecânico com sistemas de instrumentação rotatória, reciprocante e híbrida e após o uso da medicação intracanal; 3) Relacionar sinais e sintomas clínicos com níveis de endotoxinas, micro-orgnismos e com complexos bacterianos; 4) Relacionar volumetria dos canais radiculares por meio de TCFC com níveis de endotoxina, micro-organismos e complexos bacterianos. Trinta dentes com infecção endodôntica primária e presença de lesão periapical foram submetidos a TCFC antes do tratamento e avaliados quanto a presença de sinais e sintomas clínicos. Após abertura coronária, foi realizada a coleta inicial nos canais radiculares, e em seguida, procedeu-se com o tratamento endodôntico, sendo os dentes divididos em diferentes grupos experimentais de acordo com o sistema de instrumentação utilizado (n=10): rotatório Mtwo (MTWO), reciprocante Reciproc (REC), e híbrido Genius (GEN). Durante o preparo biomecânico, os canais foram irrigados com 24 mL de NaOCl 2,5%. Foram realizadas coletas do conteúdo dos canais radiculares: logo após a abertura coronária (1 col), após a instrumentação (2 col), e após a MIC por 14 dias, realizada com pasta de hidróxido de cálcio associada a solução salina fisiológica (3 col). A detecção de micro-organimos foi realizada pelo teste checkerboard DNA-DNA hybridization. A quantificação de endotoxinas foi realizada pelo teste cinético cromogênio do lisado de amebócito de Limulus. As volumetrias dos canais radiculares foram realizadas com auxílio do software Nemotec®. Todos os dados foram analisados estatisticamente. Os resultados mostraram a detecção de micro-organismos e endotoxinas em 100% das amostras iniciais, sendo as bactérias C. ochracea e F. nucleatum as mais prevalentes (53%). Após o PBM, os micro-organismos mais encontrados foram F. nucleatum e L. buccalis (50%); e após a MIC C. gracilis (53,3%). Não houve diferença estatística entre os grupos quanto à redução da carga microbiana. Quanto as endotoxinas, logo após o PBM, o grupo que mais reduziu foi o MTWO, seguido por GEN e REC; após a MIC, o grupo que mais reduziu foi o GEN, seguido pelo MTWO e REC, porém todos os grupos se comportaram de maneira semelhante. Dor espontânea foi relacionada com P. nigrescens; dor a percussão com P. gingivalis, V. parvula, S. sputigena, P. nigrescens e E. saburreum; presença de fístula foi relacionada com o complexo laranja, Gram-positivas e anaeróbios facultativos, e micro-organismos E. corrodens, P. micra, C. showae e E. saburreum. O maior volume do canal radicular foi correlacionado fortemente com anaeróbios estritos, com o complexo laranja e o micro-organismo P. micra. O PBM foi efetivo na redução de bactérias e endotoxinas do canal radicular, mas sem diferença estatística entre os três sistemas utilizados. Conclui-se que o PBM com… Advisors/Committee Members: Garakis, Marcia Carneiro Valera [UNESP], Cardoso, Flávia Goulart da Rosa [UNESP], Universidade Estadual Paulista (UNESP).

Subjects/Keywords: Endotoxina; Instrumentação; Microbiota; Endotoxin; Instrumentation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cavalli, D. [. (2017). Estudo comparativo de sistemas rotatório, reciprocante e híbrido no preparo de canais radiculares em dentes com infecção endodôntica primária: perfil microbiano e quantificação de endotoxinas. (Thesis). Universidade Estadual Paulista. Retrieved from http://hdl.handle.net/11449/148838

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cavalli, Daiana [UNESP]. “Estudo comparativo de sistemas rotatório, reciprocante e híbrido no preparo de canais radiculares em dentes com infecção endodôntica primária: perfil microbiano e quantificação de endotoxinas.” 2017. Thesis, Universidade Estadual Paulista. Accessed January 23, 2021. http://hdl.handle.net/11449/148838.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cavalli, Daiana [UNESP]. “Estudo comparativo de sistemas rotatório, reciprocante e híbrido no preparo de canais radiculares em dentes com infecção endodôntica primária: perfil microbiano e quantificação de endotoxinas.” 2017. Web. 23 Jan 2021.

Vancouver:

Cavalli D[. Estudo comparativo de sistemas rotatório, reciprocante e híbrido no preparo de canais radiculares em dentes com infecção endodôntica primária: perfil microbiano e quantificação de endotoxinas. [Internet] [Thesis]. Universidade Estadual Paulista; 2017. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/11449/148838.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cavalli D[. Estudo comparativo de sistemas rotatório, reciprocante e híbrido no preparo de canais radiculares em dentes com infecção endodôntica primária: perfil microbiano e quantificação de endotoxinas. [Thesis]. Universidade Estadual Paulista; 2017. Available from: http://hdl.handle.net/11449/148838

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Rochester

20. Li, Hongjie. Stem cell, compartmentalization, and microbiota in the aging Drosophila intestine.

Degree: PhD, 2016, University of Rochester

URL: http://hdl.handle.net/1802/30603

► The gastrointestinal (GI) tract of most metazoans, including humans, is lined by a series of epithelia that share common digestive function, but also have distinct… (more)

Subjects/Keywords: Aging; Drosophila; Microbiota; Stem cell

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Li, H. (2016). Stem cell, compartmentalization, and microbiota in the aging Drosophila intestine. (Doctoral Dissertation). University of Rochester. Retrieved from http://hdl.handle.net/1802/30603

Chicago Manual of Style (16^th Edition):

Li, Hongjie. “Stem cell, compartmentalization, and microbiota in the aging Drosophila intestine.” 2016. Doctoral Dissertation, University of Rochester. Accessed January 23, 2021. http://hdl.handle.net/1802/30603.

MLA Handbook (7^th Edition):

Li, Hongjie. “Stem cell, compartmentalization, and microbiota in the aging Drosophila intestine.” 2016. Web. 23 Jan 2021.

Vancouver:

Li H. Stem cell, compartmentalization, and microbiota in the aging Drosophila intestine. [Internet] [Doctoral dissertation]. University of Rochester; 2016. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1802/30603.

Council of Science Editors:

Li H. Stem cell, compartmentalization, and microbiota in the aging Drosophila intestine. [Doctoral Dissertation]. University of Rochester; 2016. Available from: http://hdl.handle.net/1802/30603

University of Alberta

21. Lin,Xiaoxi. Microbial ecology of food fermentations and intestinal ecosystems.

Degree: PhD, Department of Agricultural, Food, and Nutritional Science, 2014, University of Alberta

URL: https://era.library.ualberta.ca/files/6t053h01f

► Microbiota are ubiquitous in nature. Similarities as well as differences are present between microbiota in animals and fermentation systems. The aim of the PhD project… (more)

▼ Microbiota are ubiquitous in nature. Similarities as well as differences are present between microbiota in animals and fermentation systems. The aim of the PhD project was to investigate factors affects microbial ecology in rodent and sourdough models. To determine how compromised health of the host by tumor and CPT-11 therapies affects intestinal microbiota in tumor bearing rats, qualitative and quantitative taxonomic analyses were combined to characterize intestinal microbiota during CPT-11-based chemotherapy. Both tumor and CPT-11 chemotherapy increased cecal Clostridium cluster XI and Enterobacteriaceae. The effect of dietary fibre was evaluated in the same model. Cecal butyrate concentrations and feed intake were highly correlated. Moreover, a positive correlation of the host expression of MCT1 with body weight as well as a positive correlation of the abundance of bacterial butyryl-CoA gene with cecal butyrate concentrations were obeserved. These correlations support the interpretation that the influence of dietary fibre on CPT-11 toxicity is partially mediated by an increased cecal production of butyrate. Similar to intestinal microbiota, in sourdough, cereal substrates contain various compounds that may have selective effect on sourdough microbiota. The effect of growth rate and acid resistance on microbial competitiveness in sourdoughs was evaluated by assessing competitiveness of glycerol-dehydratase (gupCDE) positive and glutamate-decarboxylase (gadB) positive strains of L. reuteri relative to the corresponding null mutants. Both glycerol and glutamate metabolism determine the competitiveness of L. reuteri in sourdough fermentations. Besides competition over shared energy source, microbes also compete with each other by producing antimicrobial compounds. Reutericyclin is an antibiotic produced by sourdough-originated L. reuteri which is bactericidal against most gram-positive bacteria. A combination comparative genomics, bioinformatics analysis, and the characterization of null-mutants was used to determine the genetic determinants of reutericyclin biosynthesis. A gene cluster unique to reutericyclin producers was identified on a genomic island acquired through lateral gene transfer. It includes genes coding for a nonribosomal peptide synthetase (NRPS), a polyketide synthase (PKS), homologues of phlABC, and putative transport and regulatory proteins. The combination of PhlABC homologues with both a NRPS and PKS is exclusive to the lactic acid bacteria Streptococcus mutans, L. plantarum and L. reuteri, indicating that the genes in these organisms share a common evolutionary origin.

Subjects/Keywords: fermentation; ecology; sourdough; microbiota; microbial

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APA (6^th Edition):

Lin,Xiaoxi. (2014). Microbial ecology of food fermentations and intestinal ecosystems. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/6t053h01f

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Chicago Manual of Style (16^th Edition):

Lin,Xiaoxi. “Microbial ecology of food fermentations and intestinal ecosystems.” 2014. Doctoral Dissertation, University of Alberta. Accessed January 23, 2021. https://era.library.ualberta.ca/files/6t053h01f.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

MLA Handbook (7^th Edition):

Lin,Xiaoxi. “Microbial ecology of food fermentations and intestinal ecosystems.” 2014. Web. 23 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

Lin,Xiaoxi. Microbial ecology of food fermentations and intestinal ecosystems. [Internet] [Doctoral dissertation]. University of Alberta; 2014. [cited 2021 Jan 23]. Available from: https://era.library.ualberta.ca/files/6t053h01f.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Council of Science Editors:

Lin,Xiaoxi. Microbial ecology of food fermentations and intestinal ecosystems. [Doctoral Dissertation]. University of Alberta; 2014. Available from: https://era.library.ualberta.ca/files/6t053h01f

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

22. Majeau, Alicia Catherine. INVESTIGATING DIFFERENTIAL ATTRACTIVENESS OF HUMAN SKIN MICROBIOTA TO ANOPHELES GAMBIAE AS A POTENTIAL COMPONENT OF BAITED SUGAR TRAPS CONTAINING ANTI-PLASMODIUM BACTERIA FOR BIOLOGICAL CONTROL.

Degree: 2014, Johns Hopkins University

URL: http://jhir.library.jhu.edu/handle/1774.2/37217

► Malaria is a pressing global health problem that is difficult to eradicate or even control because of its complex biology. Currently employed control mechanisms are… (more)

Subjects/Keywords: Plasmodium falciparum; olfaction; skin microbiota

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APA (6^th Edition):

Majeau, A. C. (2014). INVESTIGATING DIFFERENTIAL ATTRACTIVENESS OF HUMAN SKIN MICROBIOTA TO ANOPHELES GAMBIAE AS A POTENTIAL COMPONENT OF BAITED SUGAR TRAPS CONTAINING ANTI-PLASMODIUM BACTERIA FOR BIOLOGICAL CONTROL. (Thesis). Johns Hopkins University. Retrieved from http://jhir.library.jhu.edu/handle/1774.2/37217

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Majeau, Alicia Catherine. “INVESTIGATING DIFFERENTIAL ATTRACTIVENESS OF HUMAN SKIN MICROBIOTA TO ANOPHELES GAMBIAE AS A POTENTIAL COMPONENT OF BAITED SUGAR TRAPS CONTAINING ANTI-PLASMODIUM BACTERIA FOR BIOLOGICAL CONTROL.” 2014. Thesis, Johns Hopkins University. Accessed January 23, 2021. http://jhir.library.jhu.edu/handle/1774.2/37217.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Majeau, Alicia Catherine. “INVESTIGATING DIFFERENTIAL ATTRACTIVENESS OF HUMAN SKIN MICROBIOTA TO ANOPHELES GAMBIAE AS A POTENTIAL COMPONENT OF BAITED SUGAR TRAPS CONTAINING ANTI-PLASMODIUM BACTERIA FOR BIOLOGICAL CONTROL.” 2014. Web. 23 Jan 2021.

Vancouver:

Majeau AC. INVESTIGATING DIFFERENTIAL ATTRACTIVENESS OF HUMAN SKIN MICROBIOTA TO ANOPHELES GAMBIAE AS A POTENTIAL COMPONENT OF BAITED SUGAR TRAPS CONTAINING ANTI-PLASMODIUM BACTERIA FOR BIOLOGICAL CONTROL. [Internet] [Thesis]. Johns Hopkins University; 2014. [cited 2021 Jan 23]. Available from: http://jhir.library.jhu.edu/handle/1774.2/37217.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Majeau AC. INVESTIGATING DIFFERENTIAL ATTRACTIVENESS OF HUMAN SKIN MICROBIOTA TO ANOPHELES GAMBIAE AS A POTENTIAL COMPONENT OF BAITED SUGAR TRAPS CONTAINING ANTI-PLASMODIUM BACTERIA FOR BIOLOGICAL CONTROL. [Thesis]. Johns Hopkins University; 2014. Available from: http://jhir.library.jhu.edu/handle/1774.2/37217

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manchester

23. White, Emily Claire. Infection by the gastrointestinal parasite Trichuris muris: Defining the microbiota of the parasite and the host.

Degree: 2016, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:305922

►

Intestinal dwelling parasites live in close association with the complex microbiota that inhabit our intestinal tracts. The intestinal helminth, Trichuris muris, depends on these bacteria… (more)

▼

Intestinal dwelling parasites live in close association with the complex microbiota that inhabit our intestinal tracts. The intestinal helminth, Trichuris muris, depends on these bacteria for egg hatching and successful establishment of infection within the epithelium of the caecum and colon. Infection causes significant alterations to the host intestinal microbiota, including a decrease in bacterial diversity and shifts in proportions of certain bacterial groups. This is accompanied by a decrease in Foxp3+ regulatory T cells and changes to the metabolic potential of the host microbiota, consequently impacting host health. However, the factor(s) driving these changes and the existence and role of its own intestinal microbiota is unknown. Infection of C57BL/6 and immunodeficient SCID mice with a high dose (~ 200 embryonated eggs) and a low dose (~ 20 embryonated eggs) of T. muris was used to determine the impact of worm burden and the adaptive immune system on the host intestinal microbiota, in comparison to naïve controls. Microbiota analysis was performed by 16S rRNA gene denaturing gradient gel electrophoresis (DGGE) and Illumina sequencing. This revealed that infection-induced microbiota changes were dose dependent and high level infection caused an increase in the Bacteroidaceae and Enterobacteriaceae families, independently of the host adaptive immune system. Development of a surface sterilisation protocol enabled the internal T. muris microbiota to be analysed by 16S rRNA gene DGGE and fluorescence in situ hybridisation (FISH). The resulting data indicated that T. muris requires its own diverse intestinal microbiota that is derived from, but distinct to, that of its host. A core microbiota is selected and maintained by the parasite regardless of the surrounding host microbiota. The parasite microbiota is important for its fitness, shown in vitro using an antibiotic motility assay and in vivo using germ free (GF) mice. Furthermore, infection with T. muris causes a significant reduction in caecal butyrate concentrations and consequently a decrease in the expression of butyrate transporters in caecal tissue. Interestingly, the T. muris microbiota is able to produce the short-chain fatty acid (SCFA) butyrate, which the parasite is unable to make itself yet secretes into its local environment. Together these strategies promote the long term survival of T. muris within the intestinal niche, adding a new level of complexity to the interaction between the pathogen, the host and their respective microbiotas that underpins successful chronic nematode infection.

Supplementary tables A and B in appendices. Provided as a DVD.

Advisors/Committee Members: GRENCIS, RICHARD RK, ROBERTSON, DAVID DL, Grencis, Richard, Roberts, Ian, Robertson, David.

Subjects/Keywords: Microbiota; Trichuris; Helminth; Infection

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

White, E. C. (2016). Infection by the gastrointestinal parasite Trichuris muris: Defining the microbiota of the parasite and the host. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:305922

Chicago Manual of Style (16^th Edition):

White, Emily Claire. “Infection by the gastrointestinal parasite Trichuris muris: Defining the microbiota of the parasite and the host.” 2016. Doctoral Dissertation, University of Manchester. Accessed January 23, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:305922.

MLA Handbook (7^th Edition):

White, Emily Claire. “Infection by the gastrointestinal parasite Trichuris muris: Defining the microbiota of the parasite and the host.” 2016. Web. 23 Jan 2021.

Vancouver:

White EC. Infection by the gastrointestinal parasite Trichuris muris: Defining the microbiota of the parasite and the host. [Internet] [Doctoral dissertation]. University of Manchester; 2016. [cited 2021 Jan 23]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:305922.

Council of Science Editors:

White EC. Infection by the gastrointestinal parasite Trichuris muris: Defining the microbiota of the parasite and the host. [Doctoral Dissertation]. University of Manchester; 2016. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:305922

University of Georgia

24. Matteson, Cody Thomas. Using nutrients and microbiota bioassessment to investigate potential benefits of gricultural wetlands.

Degree: 2018, University of Georgia

URL: http://hdl.handle.net/10724/38373

► Here we evaluate field-to-stream water quality gradients across a forested alluvial swamp and through a ditched wetland swale on the same working farm. During 2016… (more)

Subjects/Keywords: wetlands; agriculture; nitrate; phosphorus; microbiota

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APA (6^th Edition):

Matteson, C. T. (2018). Using nutrients and microbiota bioassessment to investigate potential benefits of gricultural wetlands. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/38373

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Matteson, Cody Thomas. “Using nutrients and microbiota bioassessment to investigate potential benefits of gricultural wetlands.” 2018. Thesis, University of Georgia. Accessed January 23, 2021. http://hdl.handle.net/10724/38373.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Matteson, Cody Thomas. “Using nutrients and microbiota bioassessment to investigate potential benefits of gricultural wetlands.” 2018. Web. 23 Jan 2021.

Vancouver:

Matteson CT. Using nutrients and microbiota bioassessment to investigate potential benefits of gricultural wetlands. [Internet] [Thesis]. University of Georgia; 2018. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10724/38373.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Matteson CT. Using nutrients and microbiota bioassessment to investigate potential benefits of gricultural wetlands. [Thesis]. University of Georgia; 2018. Available from: http://hdl.handle.net/10724/38373

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

25. Markel, Melissa. Characterization of the Fecal Microbiota in Dogs with Chronic Enteropathies and Acute Hemorrhagic Diarrhea.

Degree: MS, Biomedical Sciences, 2012, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-2012-08-11634

► Recent 16S rRNA gene sequencing studies of the duodenal and fecal microbiota have revealed alterations in the abundance of specific bacterial groups in dogs with… (more)

▼ Recent 16S rRNA gene sequencing studies of the duodenal and fecal microbiota have revealed alterations in the abundance of specific bacterial groups in dogs with gastrointestinal (GI) disorders. The aim of this study was to establish a panel of quantitative real-time PCR (qPCR) assays for the evaluation of specific bacterial groups in fecal samples of healthy dogs, dogs with chronic enteropathies (CE), and dogs with acute hemorrhagic diarrhea (AHD). Fecal samples from 242 healthy dogs, 118 dogs with CE, and 57 dogs with AHD were analyzed using qPCR assays targeting Faecalibacterium spp., Turicibacter spp., Bifidobacterium spp., Lactobacillus spp., Streptococcus spp., Ruminococcaceae, C. perfringens, E. coli, gamma-Proteobacteria, Bacteroidetes, and Firmicutes). Differences in bacterial abundance among the three groups were evaluated using a Kruskal-Wallis test followed by a Dunn's post-test. A Bonferroni correction was used to correct for multiple comparisons and an adjusted p<0.05 was considered for statistical significance. Faecalibacterium spp., Turicibacter spp., and Ruminococcaceae were significantly decreased in CE and AHD compared to healthy dogs (p<0.001 for all). Lactobacillus spp. and Streptococcus spp. were significantly increased in dogs with CE (p<0.001 for both) when compared to the healthy dogs. In contrast, Lactobacillus spp. and Streptococcus spp. were significantly decreased in dogs with AHD compared to healthy dogs (p<0.01 and p<0.05, respectively) and also when compared to the dogs with CE (p<0.001 for both). C. perfringens and E. coli were significantly increased in dogs with AHD (p<0.001 and p<0.01, respectively), when compared to healthy dogs. E. coli was also significantly increased in dogs with CE when compared to the healthy dogs (p<0.001). Bacteroidetes were significantly lower in dogs with CE compared to healthy dogs (<0.001). Firmicutes were significantly higher in healthy dogs in comparison to dogs with AHD (p<0.05). Bifidobacterium spp. and gamma-Proteobacteria were not significantly different among all three groups of dogs. In conclusion, the qPCR panel employed here revealed a fecal dysbiosis in dogs with CE and AHD when compared to healthy dogs. These results are similar to recently reported findings using molecular sequencing approaches. Quantification of these bacterial groups by qPCR may be a useful adjunct for the diagnosis or monitoring of gastrointestinal disease in dogs. Advisors/Committee Members: Suchodolski, Jan S. (advisor), Steiner, Joerg M. (committee member), Lawhon, Sara (committee member).

Subjects/Keywords: canine; gastrointestinal; dysbiosis; microbiota

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Markel, M. (2012). Characterization of the Fecal Microbiota in Dogs with Chronic Enteropathies and Acute Hemorrhagic Diarrhea. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2012-08-11634

Chicago Manual of Style (16^th Edition):

Markel, Melissa. “Characterization of the Fecal Microbiota in Dogs with Chronic Enteropathies and Acute Hemorrhagic Diarrhea.” 2012. Masters Thesis, Texas A&M University. Accessed January 23, 2021. http://hdl.handle.net/1969.1/ETD-TAMU-2012-08-11634.

MLA Handbook (7^th Edition):

Markel, Melissa. “Characterization of the Fecal Microbiota in Dogs with Chronic Enteropathies and Acute Hemorrhagic Diarrhea.” 2012. Web. 23 Jan 2021.

Vancouver:

Markel M. Characterization of the Fecal Microbiota in Dogs with Chronic Enteropathies and Acute Hemorrhagic Diarrhea. [Internet] [Masters thesis]. Texas A&M University; 2012. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2012-08-11634.

Council of Science Editors:

Markel M. Characterization of the Fecal Microbiota in Dogs with Chronic Enteropathies and Acute Hemorrhagic Diarrhea. [Masters Thesis]. Texas A&M University; 2012. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2012-08-11634

McMaster University

26. Gohir, Wajiha. High-fat diet-induced obesity modulates pregnancy gut microbiota and alters maternal intestinal adaptations to pregnancy.

Degree: MSc, 2016, McMaster University

URL: http://hdl.handle.net/11375/18941

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Maternal obesity is a key predictor of childhood obesity. It has been shown to cause changes in maternal adaptation to pregnancy that result in an… (more)

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Maternal obesity is a key predictor of childhood obesity. It has been shown to cause changes in maternal adaptation to pregnancy that result in an adverse in utero environment, inducing increased risk of obesity and metabolic disease in the offspring. Perturbation of gut microbiota over the course of pregnancy has been implicated in maternal metabolic adaptations. We investigated how high-fat (HF) diet-induced obesity before and during pregnancy affects gut microbiota and maternal intestinal barrier function, and whether altered maternal gut adaptations to pregnancy influence placental development. Microbiota of HF mice was modified by diet, and further modulated by pregnancy. Changes in mucin-degrading and short chain fatty acid (SCFA) producing bacteria were found in microbiota from HF pregnant mice. SCFA receptor, GPR41, expression was reduced in the duodenum and jejunum of HF dams. Intestinal barrier function was impaired in HF pregnancies as indicated by increased paracellular intestinal permeability measured by passage of FITC-Dextran and increased concentration of bacterial lipopolysaccharide in the maternal serum, observations that were consistent with reduced gene expression of tight junction proteins in the small intestine of HF dams. Diet-induced maternal obesity altered gene expression of inflammatory and immune cell marker genes in different gut sections. However, no change in TNF and IL-6 in maternal serum suggested that HF diet-induced obesity was not associated with systemic maternal inflammation. Female placenta from HF pregnancies were smaller in size, as calculated by measuring the cross sectional area of the placenta, which may be regulated by increased apoptosis. Augmented placental inflammation was not observed in HF placentas. Changes in maternal intestinal adaptations appear to be modified by diet-induced obesity before and during pregnancy, in a manner that reduced maternal barrier function and increased intestinal immune cell markers but these changes appeared not be associated with placental pro-inflammatory status.

Thesis

Master of Science (MSc)

Advisors/Committee Members: Sloboda, Deborah, Biochemistry and Biomedical Sciences.

Subjects/Keywords: pregnancy; microbiota; obesity; maternal nutrition

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APA (6^th Edition):

Gohir, W. (2016). High-fat diet-induced obesity modulates pregnancy gut microbiota and alters maternal intestinal adaptations to pregnancy. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/18941

Chicago Manual of Style (16^th Edition):

Gohir, Wajiha. “High-fat diet-induced obesity modulates pregnancy gut microbiota and alters maternal intestinal adaptations to pregnancy.” 2016. Masters Thesis, McMaster University. Accessed January 23, 2021. http://hdl.handle.net/11375/18941.

MLA Handbook (7^th Edition):

Gohir, Wajiha. “High-fat diet-induced obesity modulates pregnancy gut microbiota and alters maternal intestinal adaptations to pregnancy.” 2016. Web. 23 Jan 2021.

Vancouver:

Gohir W. High-fat diet-induced obesity modulates pregnancy gut microbiota and alters maternal intestinal adaptations to pregnancy. [Internet] [Masters thesis]. McMaster University; 2016. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/11375/18941.

Council of Science Editors:

Gohir W. High-fat diet-induced obesity modulates pregnancy gut microbiota and alters maternal intestinal adaptations to pregnancy. [Masters Thesis]. McMaster University; 2016. Available from: http://hdl.handle.net/11375/18941

27. Morris, Marc. Biological markers demonstrate utility and predictive value in inflammatory bowel disease.

Degree: 2015, University of Saskatchewan

URL: http://hdl.handle.net/10388/ETD-2015-12-2350

► Biological markers (“biomarkers”) may have applications in inflammatory bowel disease (IBD), a chronic disease of the gastrointestinal tract. Clinicians are presented with several challenges when… (more)

▼ Biological markers (“biomarkers”) may have applications in inflammatory bowel disease (IBD), a chronic disease of the gastrointestinal tract. Clinicians are presented with several challenges when treating IBD. Instead of performing expensive and invasive endoscopic procedures - if even possible, as resources for these procedures can be limited - biomarkers could be used to diagnose, assess disease activity and prognosis, and guide medical therapy, particularly in situations where novel biologics are involved. At this time, the use of biomarkers is limited, since few have been useful in predicting disease severity, prognosis and therapeutic response in IBD. Previous research cohorts studying biomarkers are limited due to varying heterogeneity between subjects that confounds the results since patients have variable disease courses. The main aim of this work was to evaluate the utility of biomarkers in IBD. To do this, biomarkers were included into a composite score with other patient reported outcomes (PRO) to predict endoscopic disease activity. Next, we examined the role of biomarkers in newly diagnosed IBD. Lastly, fecal calprotectin (FC) was evaluated in healthy pregnant and IBD patients, establishing reference values and practicality in this clinical group. We also studied the relationship between biomarkers and environmental factors, such as fecal microbiota. We hypothesized biomarker concentration would be elevated with increased clinical and endoscopic measures, and predictive of response to medical therapy in newly diagnosed patients. Additionally, we theorized the inclusion of biomarkers into composite scores would outperform existing scoring models in predicting endoscopic severity. Furthermore, FC levels would be below the limit of detection in healthy pregnancy and elevated in IBD pregnancy. The inclusion of biomarkers into composite scoring models outperformed existing clinical scores. In newly diagnosed patients, modest relationships were found between biomarkers and clinical and endoscopic markers of disease. Lastly, the presence of FC was elevated in pregnant IBD and not significant in healthy pregnancy; thus, FC is useful in IBD and pregnancy. Our work confirmed the significance of biomarkers in several clinical areas of IBD, along with the issues presented in recruiting newly diagnosed patients in small research centres. Future work will incorporate biomarkers into medical triage and as an endpoint in nutritional interventions. Advisors/Committee Members: Zello, Gordon A., Jones, Jennifer L., Alcorn, Jane, Fowler, Sharyle A., Rodgers, Carol, Dahl, Wendy.

Subjects/Keywords: biomarkers; IBD; microbiota; nutrition.

12 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Morris, M. (2015). Biological markers demonstrate utility and predictive value in inflammatory bowel disease. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/ETD-2015-12-2350

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Morris, Marc. “Biological markers demonstrate utility and predictive value in inflammatory bowel disease.” 2015. Thesis, University of Saskatchewan. Accessed January 23, 2021. http://hdl.handle.net/10388/ETD-2015-12-2350.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Morris, Marc. “Biological markers demonstrate utility and predictive value in inflammatory bowel disease.” 2015. Web. 23 Jan 2021.

Vancouver:

Morris M. Biological markers demonstrate utility and predictive value in inflammatory bowel disease. [Internet] [Thesis]. University of Saskatchewan; 2015. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10388/ETD-2015-12-2350.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Morris M. Biological markers demonstrate utility and predictive value in inflammatory bowel disease. [Thesis]. University of Saskatchewan; 2015. Available from: http://hdl.handle.net/10388/ETD-2015-12-2350

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

28. Rangé, Hélène. Bactériémies parodontales et évolution de l'athérosclérose humaine : Periodontal bacteriemia and human atherosclerosis evolution.

Degree: Docteur es, Médecine. Pathologie cardio-vasculaire, 2016, Sorbonne Paris Cité

URL: http://www.theses.fr/2016USPCC318

►

Depuis la fin des années 1980, de nombreuses études épidémiologiques ont montré une association positive et indépendante entre les maladies cardiovasculaires et les maladies parodontales.… (more)

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Depuis la fin des années 1980, de nombreuses études épidémiologiques ont montré une association positive et indépendante entre les maladies cardiovasculaires et les maladies parodontales. Les maladies parodontales, responsables de bactériémies transitoires et répétées, ont la capacité d’initier ou d’aggraver les lésions d’athérosclérose. Deux mécanismes pathogéniques majeurs sont aujourd’hui avancés. L’un est indirect par augmentation des médiateurs de l’inflammation induite par les parodontites et l’autre est direct lié au microbiote oral. Cette hypothèse majeure repose sur deux mécanismes non exclusifs, la translocation des bactéries parodontales au sein des plaques d’athérosclérose par la circulation générale et sur la modification du microbiote intestinal. L’objectif de la thèse était d'explorer l'association entre l’exposition systémique aux bactéries parodontales et leur présence au sein des plaques d’athérosclérose sur les complications cardio- et neuro-vasculaires chez l’homme. Les résultats obtenus montrent que les bactéries parodontales sont associées à un phénotype vulnérable des plaques d’athérosclérose coronariennes et carotidiennes. Les lésions d’athérosclérose compliquées par des hémorragies intraplaques sont le siège d’une activation plus intense des neutrophiles. Les effets délétères des leucocytes sur les tissus vasculaires sont potentiellement augmentés et entretenus par les bactéries majorant la vulnérabilité à la rupture des plaques d’athérosclérose. La confirmation clinique de la relation biologique entre le microbiote parodontal et les complications cardio- et neuro-vasculaires de l’athérosclérose est une perspective importante de cette thèse.

Since the late 1980s, many epidemiological studies have shown a positive and independent association between cardiovascular disease and periodontal disease. Periodontal disease inducing transient bacteraemia, can initiate or worsen atherosclerotic lesions. Two major pathophysiologic mechanisms are supported by evidence. One is by indirect increase in inflammatory systemic periodontitis-induced mediators and the other is directly related to the oral microbiota. This major hypothesis is based on two non-exclusive mechanisms, the translocation of periodontal bacteria in atherosclerotic plaques by the general circulation and the impact on the gut microbiota.The aim of the thesis was to explore the association between systemic exposure to periodontal bacteria and their presence in atherosclerotic plaques on the cardiovascular and neurovascular complications in human.The results obtained show that periodontal bacteria are associated to a vulnerable phenotype of coronary and carotid atherosclerotic plaques. Atherosclerotic lesions complicated by intraplaque haemorrhage are the trigger of a super activation of neutrophils. The deleterious effects of leukocytes to the vascular tissues are potentially increased and maintained by the bacteria which increase the atherosclerotic plaques vulnerability to rupture.The clinical confirmation of the biological…

Advisors/Committee Members: Meilhac, Olivier (thesis director), Bouchard, Philippe (thesis director).

Subjects/Keywords: Microbiote parodontal; Periodontal microbiota

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rangé, H. (2016). Bactériémies parodontales et évolution de l'athérosclérose humaine : Periodontal bacteriemia and human atherosclerosis evolution. (Doctoral Dissertation). Sorbonne Paris Cité. Retrieved from http://www.theses.fr/2016USPCC318

Chicago Manual of Style (16^th Edition):

Rangé, Hélène. “Bactériémies parodontales et évolution de l'athérosclérose humaine : Periodontal bacteriemia and human atherosclerosis evolution.” 2016. Doctoral Dissertation, Sorbonne Paris Cité. Accessed January 23, 2021. http://www.theses.fr/2016USPCC318.

MLA Handbook (7^th Edition):

Rangé, Hélène. “Bactériémies parodontales et évolution de l'athérosclérose humaine : Periodontal bacteriemia and human atherosclerosis evolution.” 2016. Web. 23 Jan 2021.

Vancouver:

Rangé H. Bactériémies parodontales et évolution de l'athérosclérose humaine : Periodontal bacteriemia and human atherosclerosis evolution. [Internet] [Doctoral dissertation]. Sorbonne Paris Cité; 2016. [cited 2021 Jan 23]. Available from: http://www.theses.fr/2016USPCC318.

Council of Science Editors:

Rangé H. Bactériémies parodontales et évolution de l'athérosclérose humaine : Periodontal bacteriemia and human atherosclerosis evolution. [Doctoral Dissertation]. Sorbonne Paris Cité; 2016. Available from: http://www.theses.fr/2016USPCC318

29. Reis, Cátia Sofia Ferreira. Eficácia do preparo biomecânico na eliminação de um grupo de bactérias do microbiota endodôntico.

Degree: 2011, RCAAP

URL: http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ucp.pt:10400.14/7493

► O presente estudo teve como objectivo a identificação de um grupo de seis bactérias em amostras recolhidas de tecido humano pulpar em estado de infecção… (more)

Subjects/Keywords: Endodontia; Microbiota endodôntico; PCR

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APA (6^th Edition):

Reis, C. S. F. (2011). Eficácia do preparo biomecânico na eliminação de um grupo de bactérias do microbiota endodôntico. (Thesis). RCAAP. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ucp.pt:10400.14/7493

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Reis, Cátia Sofia Ferreira. “Eficácia do preparo biomecânico na eliminação de um grupo de bactérias do microbiota endodôntico.” 2011. Thesis, RCAAP. Accessed January 23, 2021. http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ucp.pt:10400.14/7493.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Reis, Cátia Sofia Ferreira. “Eficácia do preparo biomecânico na eliminação de um grupo de bactérias do microbiota endodôntico.” 2011. Web. 23 Jan 2021.

Vancouver:

Reis CSF. Eficácia do preparo biomecânico na eliminação de um grupo de bactérias do microbiota endodôntico. [Internet] [Thesis]. RCAAP; 2011. [cited 2021 Jan 23]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ucp.pt:10400.14/7493.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Reis CSF. Eficácia do preparo biomecânico na eliminação de um grupo de bactérias do microbiota endodôntico. [Thesis]. RCAAP; 2011. Available from: http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ucp.pt:10400.14/7493

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Otago

30. Krittaphol, Woravimol. Influence of the gut microbiota and probiotics on selenium metabolism in the rat: In vitro and in vivo studies .

Degree: 2011, University of Otago

URL: http://hdl.handle.net/10523/1652

► Selenium plays a major role in the immune system and in decreasing the risk of cancer. Plasma selenium levels are low in patients with certain… (more)

▼ Selenium plays a major role in the immune system and in decreasing the risk of cancer. Plasma selenium levels are low in patients with certain gastrointestinal disorders suggesting a role for the gut microbiota in selenium metabolism and disposition. Probiotic treatment can modulate the gut microbiota but the effect of such treatment on the metabolism of selenium supplements is unknown. The present study investigated the metabolism of L-selenomethionine (L-SeMet) and selenite, commonly used as selenium supplements, by probiotic bacteria in vitro and by rat gut contents ex vivo. The effect of probiotic treatment on the disposition of selenium after oral dosing with L-SeMet and selenite in rats was also investigated. After anaerobic incubation of L-SeMet (0.51 mM) with 10% w/w suspensions of the contents of jejunum, ileum, caecum and colon from male Wistar rats at 37°C for 3 h, L-SeMet metabolism (30%) was greatest in caecum contents followed by colon, ileum and jejunum. Dimethyldiselenide (DMDSe) was produced to the extent of 8.7% of the L-SeMet added and 28.9% of the L-SeMet lost. A similar result was obtained after incubation of selenite (0.58 mM) with metabolism being complete in caecum contents and almost complete in colon. Dimethylselenide (DMSe) (5.7% of the selenite added) was produced accompanied by a red precipitate of elemental selenium. When L-SeMet (0.51 mM) was incubated anaerobically with individual antibiotic-resistant probiotic strains (Streptococcus salivarius K12, Lactobacillus rhamnosus 67B, Lactobacillus acidophilus L10 and Bifidobacterium lactis LAFTI® B94) (1 - 5x1010 cfu/mL) and with a mixture of the four probiotic strains (ca. 3x1010 cfu/mL) at 37°C for 24 h, 10 - 18% was metabolised with 36-80% of L-SeMet being converted to DMDSe and DMSe. In similar incubations with selenite (0.58 mM), metabolism was more extensive (26 - 100%) particularly by the lactobacilli with 0-4.8% of selenite being converted to DMSe and DMDSe accompanied by the formation of elemental selenium. Metabolism of L-SeMet or selenite in incubations with a combination of gut contents and the four probiotic strains indicated some suppression of L-SeMet metabolism and enhancement of selenite metabolism. These results suggest probiotics and gut microorganisms interact in relation to selenium metabolism in the gut. In the in vivo study, three groups of rats (n = 3/group) were given saline or a single oral dose of 2 mg selenium/kg as L-SeMet or selenite by gavage (untreated rats). Another four groups of rats (n = 6/group) were given the same dose of either L-SeMet or selenite (2 mg selenium/kg) at the time of the last dose of treatment with 3 mL of a mixture containing equal numbers of the four antibiotic-resistant probiotic strains (total cell count ca. 1x1010 cfu/mL) or vehicle (a mixture of the lyoprotectants trehalose, maltodextrin and lactitol) every 12 h for three days (treated rats). Blood was collected from five rats in each treatment group over 24 h and serum analysed for selenium along with samples of liver… Advisors/Committee Members: Fawcett, J. Paul (advisor).

Subjects/Keywords: selenium; gut microbiota; probiotics; rat

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Krittaphol, W. (2011). Influence of the gut microbiota and probiotics on selenium metabolism in the rat: In vitro and in vivo studies . (Doctoral Dissertation). University of Otago. Retrieved from http://hdl.handle.net/10523/1652

Chicago Manual of Style (16^th Edition):

Krittaphol, Woravimol. “Influence of the gut microbiota and probiotics on selenium metabolism in the rat: In vitro and in vivo studies .” 2011. Doctoral Dissertation, University of Otago. Accessed January 23, 2021. http://hdl.handle.net/10523/1652.

MLA Handbook (7^th Edition):

Krittaphol, Woravimol. “Influence of the gut microbiota and probiotics on selenium metabolism in the rat: In vitro and in vivo studies .” 2011. Web. 23 Jan 2021.

Vancouver:

Krittaphol W. Influence of the gut microbiota and probiotics on selenium metabolism in the rat: In vitro and in vivo studies . [Internet] [Doctoral dissertation]. University of Otago; 2011. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10523/1652.

Council of Science Editors:

Krittaphol W. Influence of the gut microbiota and probiotics on selenium metabolism in the rat: In vitro and in vivo studies . [Doctoral Dissertation]. University of Otago; 2011. Available from: http://hdl.handle.net/10523/1652

Open Access Theses and Dissertations