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University of Toledo Health Science Campus
1.
Aldokhail, Abdullah M.
Automated Signal to Noise Ratio Analysis for Magnetic
Resonance Imaging Using a Noise Distribution Model.
Degree: MSBS, Biomedical Sciences (Medical Physics: Diagnostic
Radiology), 2017, University of Toledo Health Science Campus
URL: http://rave.ohiolink.edu/etdc/view?acc_num=mco1469557255 
► Signal to noise ratio (SNR) is a fundamental index of image quality in Magnetic Resonance Imaging (MRI) and it has traditionally been considered as a…
(more)
▼ Signal to noise ratio (SNR) is a fundamental index of
image quality in Magnetic Resonance
Imaging (MRI) and it has
traditionally been considered as a sensitive test to monitor the
performance of MRI systems. As part of quality assurance program,
SNR measurement should have a high level of reproducibility and
accuracy. Currently accepted methods to evaluate SNR rely upon
manual analysis and are observer dependent. The goal of this
project is to develop a robust automated method for SNR analysis to
eliminate individual’s variability when performing such a test.
This method uses a macro file that has been written using imageJ
software to automatically segment the phantom from the background
region, measure the mean signal from an area covering 80% of the
phantom and determine the noise by fitting a noise distribution
model to the background histogram. Fifty-four phantom scans from a
variety of RF coils were used to compare the automated SNR analysis
method with the manual SNR methods described in the ACR QC Manual.
The automated SNR method proved to be accurate, highly
reproducible, and relatively insensitive to the existence of minor
artifacts in the noise measurement region.
Advisors/Committee Members: Parsai, E. Ishmael (Committee Chair).
Subjects/Keywords: Medical Imaging
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APA (6th Edition):
Aldokhail, A. M. (2017). Automated Signal to Noise Ratio Analysis for Magnetic
Resonance Imaging Using a Noise Distribution Model. (Masters Thesis). University of Toledo Health Science Campus. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=mco1469557255
Chicago Manual of Style (16th Edition):
Aldokhail, Abdullah M. “Automated Signal to Noise Ratio Analysis for Magnetic
Resonance Imaging Using a Noise Distribution Model.” 2017. Masters Thesis, University of Toledo Health Science Campus. Accessed January 20, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=mco1469557255.
MLA Handbook (7th Edition):
Aldokhail, Abdullah M. “Automated Signal to Noise Ratio Analysis for Magnetic
Resonance Imaging Using a Noise Distribution Model.” 2017. Web. 20 Jan 2020.
Vancouver:
Aldokhail AM. Automated Signal to Noise Ratio Analysis for Magnetic
Resonance Imaging Using a Noise Distribution Model. [Internet] [Masters thesis]. University of Toledo Health Science Campus; 2017. [cited 2020 Jan 20].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=mco1469557255.
Council of Science Editors:
Aldokhail AM. Automated Signal to Noise Ratio Analysis for Magnetic
Resonance Imaging Using a Noise Distribution Model. [Masters Thesis]. University of Toledo Health Science Campus; 2017. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=mco1469557255
Cleveland State University
2.
Morgan, Ashraf.
Measuring Radiation Dose in Computed Tomography Using
Elliptic Phantom and Free-In-Air, and Evaluating Iterative Metal
Artifact Reduction Algorithm.
Degree: Doctor of Engineering, Washkewicz College of Engineering, 2016, Cleveland State University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=csu1472078731
► The need for an accurate and reliable way for measuring patient dose in multi-row detector computed tomography (MDCT) has increased significantly. This research was focusing…
(more)
▼ The need for an accurate and reliable way for
measuring patient dose in multi-row detector computed tomography
(MDCT) has increased significantly. This research was focusing on
the possibility of measuring CT dose in air to estimate Computed
Tomography Dose Index (CTDI) for routine quality control purposes.
New elliptic CTDI phantom that better represent human geometry was
manufactured for investigating the effect of the
subject shape on
measured CTDI. Monte Carlo simulation was utilized in order to
determine the dose distribution in comparison to the traditional
cylindrical CTDI phantom. This research also investigated the
effect of Siemens health care newly developed iMAR (iterative metal
artifact reduction) algorithm, arthroplasty phantom was designed
and manufactured that purpose. The design of new phantoms was part
of the research as they mimic the human geometry more than the
existing CTDI phantom. The standard CTDI phantom is a right
cylinder that does not adequately represent the geometry of the
majority of the patient population. Any dose reduction algorithm
that is used during patient scan will not be utilized when scanning
the CTDI phantom, so a better-designed phantom will allow the use
of dose reduction algorithms when measuring dose, which leads to
better dose estimation and/or better understanding of dose
delivery. Doses from a standard CTDI phantom and the newly-designed
phantoms were compared to doses measured in air. Iterative
reconstruction is a promising technique in MDCT dose reduction and
artifacts correction. Iterative reconstruction algorithms have been
developed to address specific
imaging tasks as is the case with
Iterative Metal Artifact Reduction or iMAR which was developed by
Siemens and is to be in use with the company’s future computed
tomography platform. The goal of iMAR is to reduce metal artifact
when
imaging patients with metal implants and recover CT number of
tissues adjacent to the implant. This research evaluated iMAR
capability of recovering CT numbers and reducing noise. Also, the
use of iMAR should allow using lower tube voltage instead of 140
KVp which is used frequently to image patients with shoulder
implants. The evaluations of image quality and dose reduction were
carried out using an arthroplasty phantom.
Advisors/Committee Members: Dong, Frank (Committee Chair).
Subjects/Keywords: Medical Imaging
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APA (6th Edition):
Morgan, A. (2016). Measuring Radiation Dose in Computed Tomography Using
Elliptic Phantom and Free-In-Air, and Evaluating Iterative Metal
Artifact Reduction Algorithm. (Doctoral Dissertation). Cleveland State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=csu1472078731
Chicago Manual of Style (16th Edition):
Morgan, Ashraf. “Measuring Radiation Dose in Computed Tomography Using
Elliptic Phantom and Free-In-Air, and Evaluating Iterative Metal
Artifact Reduction Algorithm.” 2016. Doctoral Dissertation, Cleveland State University. Accessed January 20, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=csu1472078731.
MLA Handbook (7th Edition):
Morgan, Ashraf. “Measuring Radiation Dose in Computed Tomography Using
Elliptic Phantom and Free-In-Air, and Evaluating Iterative Metal
Artifact Reduction Algorithm.” 2016. Web. 20 Jan 2020.
Vancouver:
Morgan A. Measuring Radiation Dose in Computed Tomography Using
Elliptic Phantom and Free-In-Air, and Evaluating Iterative Metal
Artifact Reduction Algorithm. [Internet] [Doctoral dissertation]. Cleveland State University; 2016. [cited 2020 Jan 20].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=csu1472078731.
Council of Science Editors:
Morgan A. Measuring Radiation Dose in Computed Tomography Using
Elliptic Phantom and Free-In-Air, and Evaluating Iterative Metal
Artifact Reduction Algorithm. [Doctoral Dissertation]. Cleveland State University; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=csu1472078731
3.
Punugu, Venkatapavani Pallavi.
Machine Learning in Neuroimaging.
Degree: 2017, State University of New York at Buffalo
URL: http://pqdtopen.proquest.com/#viewpdf?dispub=10284048
► The application of machine learning algorithms to analyze and determine disease related patterns in neuroimaging has emerged to be of extreme interest in Computer-Aided…
(more)
▼ The application of machine learning algorithms to analyze and determine disease related patterns in neuroimaging has emerged to be of extreme interest in Computer-Aided Diagnosis (CAD). This study is a small step towards categorizing Alzheimer's disease, Neurode-generative diseases, Psychiatric diseases and Cerebrovascular Small Vessel diseases using CAD. In this study, the SPECT neuroimages are pre-processed using powerful data reduction techniques such as Singular Value Decomposition (SVD), Independent Component Analysis (ICA) and Automated Anatomical Labeling (AAL). Each of the pre-processing methods is used in three machine learning algorithms namely: Artificial Neural Networks (ANNs), Support Vector Machines (SVMs) and k-Nearest Neighbors (k-nn) to recognize disease patterns and classify the diseases. While neurodegenerative diseases and psychiatric diseases overlap with a mix of diseases and resulted in fairly moderate classification, the classification between Alzheimer's disease and Cerebrovascular Small Vessel diseases yielded good results with an accuracy of up to 73.7%.
Subjects/Keywords: Medical imaging
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APA (6th Edition):
Punugu, V. P. (2017). Machine Learning in Neuroimaging. (Thesis). State University of New York at Buffalo. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=10284048
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Punugu, Venkatapavani Pallavi. “Machine Learning in Neuroimaging.” 2017. Thesis, State University of New York at Buffalo. Accessed January 20, 2020.
http://pqdtopen.proquest.com/#viewpdf?dispub=10284048.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Punugu, Venkatapavani Pallavi. “Machine Learning in Neuroimaging.” 2017. Web. 20 Jan 2020.
Vancouver:
Punugu VP. Machine Learning in Neuroimaging. [Internet] [Thesis]. State University of New York at Buffalo; 2017. [cited 2020 Jan 20].
Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10284048.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Punugu VP. Machine Learning in Neuroimaging. [Thesis]. State University of New York at Buffalo; 2017. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10284048
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
4.
Miles, Jadrian.
A Multi-Scale Model of Brain White-Matter Structure and Its
Fitting Method for Diffusion MRI.
Degree: PhD, Computer Science, 2015, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:419545/
► This dissertation describes three primary contributions to the field of medical imaging: (1) a mathematical model ("Blockhead") of the macroscopic and microscopic structure of the…
(more)
▼ This dissertation describes three primary
contributions to the field of
medical imaging: (1) a mathematical
model ("Blockhead") of the macroscopic and microscopic structure of
the white matter of the human brain; (2) a technique for computing
the parameters of such a model from MRI scans of a given
subject;
and (3) an application of existing statistical tools to compare
instances of any different tissue models according to their
accuracy and parsimony with respect to MR images of the
subject.
The Blockhead model has both discrete and continuous parameters. As
such the fitting method demonstrates a novel synthesis of
techniques from combinatorial and numerical optimization: namely,
the inclusion of short gradient-descent steps into the neighborhood
of a local-search solver. The thesis of this work is that this
multi-scale tissue model admits of an instance that, for certain
inputs with simple geometry, has better fit to the input (in the
sense of accuracy and parsimony) than current voxel-oriented
techniques. Furthermore the fitting method is capable, in some
circumstances, of computing this model instance. The dissertation
also details the shortcomings of this model and proposes future
refinements to better represent realistic tissue
geometry.
Advisors/Committee Members: Laidlaw, David (Director), Hughes, John (Reader), Raphael, Ben (Reader), Basser, Peter (Reader).
Subjects/Keywords: Medical Imaging
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APA (6th Edition):
Miles, J. (2015). A Multi-Scale Model of Brain White-Matter Structure and Its
Fitting Method for Diffusion MRI. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:419545/
Chicago Manual of Style (16th Edition):
Miles, Jadrian. “A Multi-Scale Model of Brain White-Matter Structure and Its
Fitting Method for Diffusion MRI.” 2015. Doctoral Dissertation, Brown University. Accessed January 20, 2020.
https://repository.library.brown.edu/studio/item/bdr:419545/.
MLA Handbook (7th Edition):
Miles, Jadrian. “A Multi-Scale Model of Brain White-Matter Structure and Its
Fitting Method for Diffusion MRI.” 2015. Web. 20 Jan 2020.
Vancouver:
Miles J. A Multi-Scale Model of Brain White-Matter Structure and Its
Fitting Method for Diffusion MRI. [Internet] [Doctoral dissertation]. Brown University; 2015. [cited 2020 Jan 20].
Available from: https://repository.library.brown.edu/studio/item/bdr:419545/.
Council of Science Editors:
Miles J. A Multi-Scale Model of Brain White-Matter Structure and Its
Fitting Method for Diffusion MRI. [Doctoral Dissertation]. Brown University; 2015. Available from: https://repository.library.brown.edu/studio/item/bdr:419545/
Boston University
5.
Hendry, Owen MacLeod.
Quantitative T1 mapping in cardiomyopathy.
Degree: MS, Bioimaging, 2014, Boston University
URL: http://hdl.handle.net/2144/15333
► Recent advancements in techniques of Cardiac Magnetic Resonance Imaging provide extended quantitative measurements of myocardial T1. Important tissue characteristics can be tracked noninvasively to allow…
(more)
▼ Recent advancements in techniques of Cardiac Magnetic Resonance Imaging provide extended quantitative measurements of myocardial T1. Important tissue characteristics can be tracked noninvasively to allow practitioners to quantify important properties of regional and global myocardium function. Quantification of these T1 measures involves the compilation of multiple images to create a T1 recovery curve, providing a map that estimates the T1 value as an encoded pixel value. After contrast injection, the data is compared with native (no applied contrast agent) T1 to examine myocardial disease involving the interstitium as well as the extracellular volume fraction. Myocardial T1 mapping is an emerging biomarker for quantification of myocardial disease (since an important indicator of heart disease is the expansion of myocardial interstitial space, as is fibrosis).
This paper explores the detection and quantification of cardiac involvement using delayed gadolinium enhancement combined with T1 mapping and myocardial extracellular volume fraction. It extends the research being conducted on Cardiac sarcoidosis, an important cardiomyopathy. Cardiac sarcoidosis is a multisystem granulomatous disease of unknown etiology. Cardiac MR is able to detect the active, inflammatory phase of the disease as well as the chronic phase where scarring and fibrosis are dominant. The use of gadolinium-based contrast agents improves the ability to discriminate ischemic from nonischemic etiologies, owing to different patterns among the various nonischemic cardiomyopathies. Since gadolinium shortens T1 relaxation time, the result is a brighter signal intensity in areas with increased interstitial space on inversion recovery T1-weighted sequences.
The 1.5 Tesla Philips Achieva XR Scanner was used to collect the pre- and post- contrast images from five anonymous patients (subjects), following the MOLLI protocol. These images were stacked and run through MRMap, which creates parametric image maps of the MOLLI data. Data was graphed employing the Gado Partition Coefficient.
Subjects/Keywords: Medical imaging
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APA ·
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Manager
APA (6th Edition):
Hendry, O. M. (2014). Quantitative T1 mapping in cardiomyopathy. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/15333
Chicago Manual of Style (16th Edition):
Hendry, Owen MacLeod. “Quantitative T1 mapping in cardiomyopathy.” 2014. Masters Thesis, Boston University. Accessed January 20, 2020.
http://hdl.handle.net/2144/15333.
MLA Handbook (7th Edition):
Hendry, Owen MacLeod. “Quantitative T1 mapping in cardiomyopathy.” 2014. Web. 20 Jan 2020.
Vancouver:
Hendry OM. Quantitative T1 mapping in cardiomyopathy. [Internet] [Masters thesis]. Boston University; 2014. [cited 2020 Jan 20].
Available from: http://hdl.handle.net/2144/15333.
Council of Science Editors:
Hendry OM. Quantitative T1 mapping in cardiomyopathy. [Masters Thesis]. Boston University; 2014. Available from: http://hdl.handle.net/2144/15333
Boston University
6.
Dunn, Matthew Christopher.
Multiparametric 3 Tesla magnetic resonance imaging as a clinical tool to characterize prostate cancer.
Degree: MS, Bioimaging, 2014, Boston University
URL: http://hdl.handle.net/2144/15343
► Scientists have come a long way in understanding prostate cancer as a disease and how its progression affects the men who develop it. Prostate adenocarcinoma…
(more)
▼ Scientists have come a long way in understanding prostate cancer as a disease and how its progression affects the men who develop it. Prostate adenocarcinoma may be present without causing clinical symptoms. Prostate cancer may metastasize, which increases the likelihood of fatality. The cause of the disease is still not completely clear, but genetics, race, tissue damage, history of previous infections, diet, and environmental influences appear to play a role in its development. Magnetic resonance imaging (MRI) has become an excellent clinical tool to characterize prostate cancer without the use of ionizing radiation or surgery. It is concluded that MRI is the optimal imaging modality to achieve detection, characterization, and staging of intracapsular and extracapsular prostate disease. The advances in MRI technology, particularly 3 Tesla, allows for reduced surgical intervention thus improving quality of life for patients with the disease.
Subjects/Keywords: Medical imaging
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APA (6th Edition):
Dunn, M. C. (2014). Multiparametric 3 Tesla magnetic resonance imaging as a clinical tool to characterize prostate cancer. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/15343
Chicago Manual of Style (16th Edition):
Dunn, Matthew Christopher. “Multiparametric 3 Tesla magnetic resonance imaging as a clinical tool to characterize prostate cancer.” 2014. Masters Thesis, Boston University. Accessed January 20, 2020.
http://hdl.handle.net/2144/15343.
MLA Handbook (7th Edition):
Dunn, Matthew Christopher. “Multiparametric 3 Tesla magnetic resonance imaging as a clinical tool to characterize prostate cancer.” 2014. Web. 20 Jan 2020.
Vancouver:
Dunn MC. Multiparametric 3 Tesla magnetic resonance imaging as a clinical tool to characterize prostate cancer. [Internet] [Masters thesis]. Boston University; 2014. [cited 2020 Jan 20].
Available from: http://hdl.handle.net/2144/15343.
Council of Science Editors:
Dunn MC. Multiparametric 3 Tesla magnetic resonance imaging as a clinical tool to characterize prostate cancer. [Masters Thesis]. Boston University; 2014. Available from: http://hdl.handle.net/2144/15343
Boston University
7.
Aisaborhale, Ehimen Edward.
Relationship between primary liver hepatocellular carcinoma volumes on portal-venous phase CT imaging.
Degree: MS, Bioimaging, 2014, Boston University
URL: http://hdl.handle.net/2144/15388
► The liver is an important organ in the body. It is located under the rib cage on the right side. The liver performs many important…
(more)
▼ The liver is an important organ in the body. It is located under the rib cage on the right side. The liver performs many important functions, it processes food for nutrients that the body requires and also helps in the detoxification of harmful materials. Like any organ in the body, the liver is susceptible to diseases such as liver cancer. Liver cancer is the growth and spread of unhealthy cells of the liver. There are several risk factor for liver cancer, these are: Cirrhosis (scarring of the liver), long term hepatitis B and hepatitis C infection and diabetes patients with long term drinking problem. Hepatocellular Carcinoma is the most common form of liver cancer in adult population which begins in the main type of liver cell (hepatocyte). Because Hepatocellular carcinoma starts from the primary liver cell itself (hepatocytes), as such it is a primary liver cancer. About 30,000 Americans are diagnosed with primary liver cancer yearly, making it an important disease that plaques our society and therefore needs proper diagnosis.
In clinical evaluation of primary liver cancer such as HCC, the use of medical imaging technology has been commonplace. Most medical facilities across the country and globally typically use Computed Tomography (CT) and/or Magnetic Resonance Imaging (MRI) in the diagnosis and treatment follow up of Hepatocellular carcinoma. The medical imaging devices are used to determine the extent and volume of the tumor of the cancerous liver cells. In clinical trials involving the imaging of HCC tumors, the typical protocol used in the CT imaging of HCC involves the use of contrast enhanced dual phase acquisition. This approach is based on the physiology of the blood flow through the liver. Since HCC tumors are hypervascular in nature, it would thus be more apparent in the arterial phase of an acquired CT image. The aforementioned characteristic was tested with a volume paradigm which measure and compare the volume of both the arterial phase and portal venous phase acquired images in the experiment. Overall this study helps in furthering goals to reduce the patient dose from the x-ray tubes during clinical trials. The results of the experiments (n = 19, t = 0.67, p = 0.26), indicates no significant difference between the volume of the HCC tumor images acquired both in the AP and PVP.
Subjects/Keywords: Medical imaging
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APA ·
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APA (6th Edition):
Aisaborhale, E. E. (2014). Relationship between primary liver hepatocellular carcinoma volumes on portal-venous phase CT imaging. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/15388
Chicago Manual of Style (16th Edition):
Aisaborhale, Ehimen Edward. “Relationship between primary liver hepatocellular carcinoma volumes on portal-venous phase CT imaging.” 2014. Masters Thesis, Boston University. Accessed January 20, 2020.
http://hdl.handle.net/2144/15388.
MLA Handbook (7th Edition):
Aisaborhale, Ehimen Edward. “Relationship between primary liver hepatocellular carcinoma volumes on portal-venous phase CT imaging.” 2014. Web. 20 Jan 2020.
Vancouver:
Aisaborhale EE. Relationship between primary liver hepatocellular carcinoma volumes on portal-venous phase CT imaging. [Internet] [Masters thesis]. Boston University; 2014. [cited 2020 Jan 20].
Available from: http://hdl.handle.net/2144/15388.
Council of Science Editors:
Aisaborhale EE. Relationship between primary liver hepatocellular carcinoma volumes on portal-venous phase CT imaging. [Masters Thesis]. Boston University; 2014. Available from: http://hdl.handle.net/2144/15388
Boston University
8.
Nadershahh, Mohammed.
Assessment of the healing of vascularized fibula bone graft in the reconstruction of the mandible using computed tomography.
Degree: MS, Bioimaging, 2015, Boston University
URL: http://hdl.handle.net/2144/15714
► PURPOSE: Vascularized bone graft has become the standard for the reconstruction of large Mandibular defects, those with soft tissue defect or after radiation to the…
(more)
▼ PURPOSE: Vascularized bone graft has become the standard for the reconstruction of large Mandibular defects, those with soft tissue defect or after radiation to the area. Fibula free flap represents the workhorse for simultaneous bone and soft tissue reconstruction of the Mandible. The aim of this study is to quantify bone formation, if any, in the graft-mandible and graft-graft gaps using computed tomography (CT) scans by developing a reliable threshold-based post-imaging processing tool, compare the healing of fibula to the mandible to the healing of the fibula to itself using this tool, and to investigate potential factors affecting bone formation specifically the linear distance between the bony edges during surgery.
PATIENTS AND METHODS: This is a multicenter study centered at Boston medical center. DICOM images were analyzed using Osirix software (V.3.7.1, 32 bits) after blinding identifying data. The inclusion criteria for this study: 1) patients received a vascularized Fibula free flap for Mandible reconstruction; 2) patients who have at least 2 postoperative CT scans with at least one month interval; 3) the first CT is within the first 3 months after the surgery; 4) no signs of clinical failure of the graft or hardware failure. The reliability of this technique was tested using two independent blinded examiners. Each blinded examiner tested each scan three times. Pearson's correlation coefficient was used to assess inter-rater reliability while the mean, Standard deviation error, and standard deviation of the mean assessed the intra-rater reliability. Paired T-test was used to compare the amount of volume change over time in participants who had both graft-graft gaps and graft-Mandible gaps. Multiple linear regressions were used to investigate the relation between the initial linear distance between the bony edges of the gap, age, and time interval against the percentage of change in gap volume. All statistics were conducted using Microsoft excel software and SPSS.
RESULTS: Twenty bony gaps from nine subjects were included in this study. This includes five graft-graft gaps and fifteen graft-Mandible gaps. The first post-operative CT scan was done within first three months after surgery (range= 2-77 days, mean= 22.2 days). Each subject had two CT scans with time interval ranging between 33 days to 390 days (mean= 191.1 days). The subjects' age ranged between 30 and 72 years (mean= 56.1 years). 12 bony gaps were used for assessing inter-rater and intra-rater reliability. The Pearson's correlation coefficient for inter-rater reliability was 0.94. Inter-reliability standard deviation error average was 0.03 and the standard error of the mean average was 0.003. Two-tailed paired T-test comparing the interval change in volume of graft-graft gaps to graft-Mandible gaps was 0.304. We found a significant negative correlation between absolute volume change and distance in mm (Pearson =-0.476, p-value=0.017). 22.7% of the variability in volume change can be explained by the initial linear distance between the bony…
Subjects/Keywords: Medical imaging
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APA ·
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to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Nadershahh, M. (2015). Assessment of the healing of vascularized fibula bone graft in the reconstruction of the mandible using computed tomography. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/15714
Chicago Manual of Style (16th Edition):
Nadershahh, Mohammed. “Assessment of the healing of vascularized fibula bone graft in the reconstruction of the mandible using computed tomography.” 2015. Masters Thesis, Boston University. Accessed January 20, 2020.
http://hdl.handle.net/2144/15714.
MLA Handbook (7th Edition):
Nadershahh, Mohammed. “Assessment of the healing of vascularized fibula bone graft in the reconstruction of the mandible using computed tomography.” 2015. Web. 20 Jan 2020.
Vancouver:
Nadershahh M. Assessment of the healing of vascularized fibula bone graft in the reconstruction of the mandible using computed tomography. [Internet] [Masters thesis]. Boston University; 2015. [cited 2020 Jan 20].
Available from: http://hdl.handle.net/2144/15714.
Council of Science Editors:
Nadershahh M. Assessment of the healing of vascularized fibula bone graft in the reconstruction of the mandible using computed tomography. [Masters Thesis]. Boston University; 2015. Available from: http://hdl.handle.net/2144/15714
Boston University
9.
Rahimpour, Yashar.
Compressed sensing and undersampling k-space.
Degree: MS, Bioimaging, 2015, Boston University
URL: http://hdl.handle.net/2144/16257
► In the field of medical imaging, one of the most important concepts consists of the creation of the image from an obtained signal. The creation…
(more)
▼ In the field of medical imaging, one of the most important concepts consists of the creation of the image from an obtained signal. The creation of the image is broken down into a subset of tasks. The first is the basic concept of isolating the element crucial to creating an image. One example is the isolation of different atoms in different modalities, for example PET or SPECT. Second, is using the intrinsic properties of these atoms to create a signal that can be recorded, this is done by magnets, gradients, coils, and other technological advances specific to other imaging modalities. Third, is the method used to record the signal. This can be done in many different ways, including but not limited to, radon space and k-space. Last but not least is the transform of the data in their respective spaces into images that are read by technologists. What is described here is, a very simple explanation for the process that different modalities go through in order to create an image. This review paper will be focused mainly on k-space acquisition and the different ways that the acquisition of k-space and image creation can be accelerated to improve patient time spent in the machine.
Subjects/Keywords: Medical imaging
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APA (6th Edition):
Rahimpour, Y. (2015). Compressed sensing and undersampling k-space. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/16257
Chicago Manual of Style (16th Edition):
Rahimpour, Yashar. “Compressed sensing and undersampling k-space.” 2015. Masters Thesis, Boston University. Accessed January 20, 2020.
http://hdl.handle.net/2144/16257.
MLA Handbook (7th Edition):
Rahimpour, Yashar. “Compressed sensing and undersampling k-space.” 2015. Web. 20 Jan 2020.
Vancouver:
Rahimpour Y. Compressed sensing and undersampling k-space. [Internet] [Masters thesis]. Boston University; 2015. [cited 2020 Jan 20].
Available from: http://hdl.handle.net/2144/16257.
Council of Science Editors:
Rahimpour Y. Compressed sensing and undersampling k-space. [Masters Thesis]. Boston University; 2015. Available from: http://hdl.handle.net/2144/16257
UCLA
10.
Wang, Da.
M1-Space Under-Sampling Fast Phase Contrast Magnetic Resonance Imaging.
Degree: Biomedical Physics, 2017, UCLA
URL: http://www.escholarship.org/uc/item/3hg9044p
► Phase Contrast Magnetic Resonance Imaging (PC-MRI) is one of the primary means for quantification of blood flow and velocity. In conventional PC-MRI, the Flow Compensated…
(more)
▼ Phase Contrast Magnetic Resonance Imaging (PC-MRI) is one of the primary means for quantification of blood flow and velocity. In conventional PC-MRI, the Flow Compensated (FC) and the three-directional (3D) Flow Encoded (FE) images are acquired in an interleaved fashion, and each directional blood flow velocity is encoded in the phase difference between each directional FE and the FC data. This acquisition strategy often limits its achievable temporal sampling period and temporal footprint. Temporal sampling period and temporal footprint are two important indices govern the measurement accuracy of the maximum peak velocity. The underestimation of the maximum peak velocity due to long temporal sampling period and long temporal footprint may result in misdiagnosis of a number of clinical diseases, such as artery stenosis. In the conventional 4D flow PC-MRI, each cardiac phase requires four acquisitions (i.e. one FC and 3D FE, FC/3FE) to update the 3D velocity vector field. Thus, the temporal sampling period and temporal footprint of 4D flow PC-MRI equal to 4*TR*Views-per-segment. Using a small views-per-segment (VPS) can achieve a decreased temporal sampling period and temporal footprint but concomitantly increase the total scan time. So far, fast PC-MRI techniques are majorly implemented to compensate the increase of the total acquisition time. In this work, we first introduce the gradient first moment (M1) space under-sampling, which aims to reduce the number of the four samples (FC and 3D FE) required for 4D flow reconstruction. This is the unique advantage of M1-space under-sampling over conventional fast PC-MRI techniques. It can improve both the temporal sampling period and temporal footprint without increasing the total scan time or reduce the total scan time with fixed temporal sampling period and temporal footprint. Furthermore, the M1-space is a novel dimension to accelerate 4D flow scans, so it can be combined with K-space, K-t-space, temporal dimension fast PC-MRI techniques to achieve further acceleration. In Chapter 2, we propose a technique to use sliding window temporal view sharing of the FC data (FCVS) to accelerate PC-MRI. The technique aims to accelerate certain PC-MRI applications, such as assessment of volumetric blood flow in the carotid arteries, intracranial vessels and peripheral vessels, where the physiological motion is minor and the FC background phase is not expected to change significantly over time. In this regard, the conventional PC-MRI acquisition strategy is redundant since it repetitively acquires the similar FC data for each cardiac phase. Especially the FC data does not contain dynamic flow velocity information. The FCVS technique achieves two-fold acceleration compared to standard through-plane encoding (FC/FE) PC-MRI. More importantly, the FCVS approach improves both the temporal sampling period and temporal footprint, which are very important for accurate velocity and flow quantification. Computational simulations and both retrospective and prospective in vivo studies…
Subjects/Keywords: Medical imaging
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APA (6th Edition):
Wang, D. (2017). M1-Space Under-Sampling Fast Phase Contrast Magnetic Resonance Imaging. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/3hg9044p
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Wang, Da. “M1-Space Under-Sampling Fast Phase Contrast Magnetic Resonance Imaging.” 2017. Thesis, UCLA. Accessed January 20, 2020.
http://www.escholarship.org/uc/item/3hg9044p.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Wang, Da. “M1-Space Under-Sampling Fast Phase Contrast Magnetic Resonance Imaging.” 2017. Web. 20 Jan 2020.
Vancouver:
Wang D. M1-Space Under-Sampling Fast Phase Contrast Magnetic Resonance Imaging. [Internet] [Thesis]. UCLA; 2017. [cited 2020 Jan 20].
Available from: http://www.escholarship.org/uc/item/3hg9044p.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Wang D. M1-Space Under-Sampling Fast Phase Contrast Magnetic Resonance Imaging. [Thesis]. UCLA; 2017. Available from: http://www.escholarship.org/uc/item/3hg9044p
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
UCLA
11.
Lee, Sungah.
Quantitative Analysis of Human Facial Expression: Moving Towards The Creation of a Virtual Patient.
Degree: Oral Biology, 2017, UCLA
URL: http://www.escholarship.org/uc/item/6m022427
► ABSTRACT OF THE THESISQuantitative Analysis of Human Facial Expression: Moving Towards The Creation of a Virtual PatientBy Sungah Lee Master of Science in Oral Biology…
(more)
▼ ABSTRACT OF THE THESISQuantitative Analysis of Human Facial Expression: Moving Towards The Creation of a Virtual PatientBy Sungah Lee Master of Science in Oral Biology University of California Los Angeles, 2017Background: Recent introduction of three dimensional facial images allows us to have access to more information than ever before, creating the potential for more accurate facial evaluation. In orthodontic diagnostics and treatment planning, facial soft tissue analysis has been broadly recognized as a critical factor leading to successful orthodontic treatment outcomes. Even though facial soft tissue is by nature dynamic data and facial expressions are the dynamic movement of these facial soft tissue, 2D static photos have been used in facial analysis in orthodontics. Our overall objective is to develop an innovative method to quantifies the dynamic movements of soft tissue in 3D during facial expressions, which could further not only orthodontics field but also other health care fields. Methods: Dynamic system to quantify 3D facial soft tissue movement was explored through investigation into physics and mathematical modeling. 3dMD facial images of 29 participants at five different time points (T1, T2, T3, T4, T5) during smiling were collected from starting of each facial expression till the end. Smiling patterns were classified and only homogenous samples were finally included. 3D meshes were processed for vertex correspondence, and 28 landmarks were tracked. Data analyses were performed via MATLAB. Average smiling faces at five different time points were generated. Average displacement vectors between each time point were computed, producing the average smiling movement trajectories. Statistical p values of all landmarks in three-dimension were computed to show the significance level of displacement. Color-coded displacement vector p maps were generated for movement of each landmark over the 5 time points. Results: 3D meshes of 10 participants at five different time points (T1, T2, T3, T4, T5) while smiling were finally included in our study. 28 landmarks were quantitatively tracked and analyzed. Average smiling faces at five time points, average displacement vectors between each time point, and statistical p values of all landmarks in 3D were generated. Average movement trajectory while smiling was generated. Corner of lip showed maximum displacement of 6.42 mm (p<~ 0.01) in upward and outward directions. Statistically Significant displacements were shown at most landmarks of oral regions (p<0.05) rather than landmarks of nasal, eye, or eyebrow regions between each time point. Conclusion: This is the first study to demonstrate that dynamic 3D movements of facial expressions can be quantitatively tracked and analyzed, offering an added dimension to the diagnosis and treatment planning of patients. This new approach which can allow us to analyze patients’ facial expressions in three dimension would shift the diagnostic paradigms currently used in craniofacial analysis, that is, 2D static facial…
Subjects/Keywords: Medical imaging
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APA ·
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APA (6th Edition):
Lee, S. (2017). Quantitative Analysis of Human Facial Expression: Moving Towards The Creation of a Virtual Patient. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/6m022427
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Lee, Sungah. “Quantitative Analysis of Human Facial Expression: Moving Towards The Creation of a Virtual Patient.” 2017. Thesis, UCLA. Accessed January 20, 2020.
http://www.escholarship.org/uc/item/6m022427.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Lee, Sungah. “Quantitative Analysis of Human Facial Expression: Moving Towards The Creation of a Virtual Patient.” 2017. Web. 20 Jan 2020.
Vancouver:
Lee S. Quantitative Analysis of Human Facial Expression: Moving Towards The Creation of a Virtual Patient. [Internet] [Thesis]. UCLA; 2017. [cited 2020 Jan 20].
Available from: http://www.escholarship.org/uc/item/6m022427.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Lee S. Quantitative Analysis of Human Facial Expression: Moving Towards The Creation of a Virtual Patient. [Thesis]. UCLA; 2017. Available from: http://www.escholarship.org/uc/item/6m022427
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Boston University
12.
Kaifi, Reham Essam.
Monitoring dynamically the gelation phase transition of agarose with diffusion QMRI as a function of temperature at 3T.
Degree: MS, Bioimaging, 2014, Boston University
URL: http://hdl.handle.net/2144/14315
► The purpose of this experiment is to observe the diffusion coefficient of agarose solution as a function of temperature during the process of gel formation.…
(more)
▼ The purpose of this experiment is to observe the diffusion coefficient of agarose solution as a function of temperature during the process of gel formation. The focus is on understanding how liquids become semi organized or semi-solid by monitoring dynamically with diffusion quantitative MRI the liquid-to-gel phase transition of pure agarose as a function of gel concentration. Four different concentrations of agarose solutions were allowed to cool down while scanning dynamically with 3 T MRI scanner (Achieva, Philips Medical Systems, Cleveland, OH) with diffusion qMRI, 70 dynamics with 56 seconds dynamic time. The 1%, 2%, 3%, and 4% agarose solutions were prepared by pouring agarose powder in distilled water and heating the solutions until they reached the boiling point ~80°C and completely dissolved. Then, scanning the phantoms dynamically as these cooled down immediately after preparation. A single axial slice diffusion-weighted-imaging turbo-spin-echo (DWI-TSE) pulse sequence was used. The diffusion versus time (temperature) curves of different agarose solutions show a distinct phase transition region characterized by a hump of increased diffusion. The diffusion coefficient as a function of time (temperature) curves of all the four concentrations shows similar behaviors with a phase transition characterized by a hump shaped at about 24 minutes at which time the gelation phase transition begins. These results may be useful for testing theoretical models of the NMR diffusion coefficient properties during liquids transforming to semi organized or semi solid
Subjects/Keywords: Medical imaging
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APA ·
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APA (6th Edition):
Kaifi, R. E. (2014). Monitoring dynamically the gelation phase transition of agarose with diffusion QMRI as a function of temperature at 3T. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/14315
Chicago Manual of Style (16th Edition):
Kaifi, Reham Essam. “Monitoring dynamically the gelation phase transition of agarose with diffusion QMRI as a function of temperature at 3T.” 2014. Masters Thesis, Boston University. Accessed January 20, 2020.
http://hdl.handle.net/2144/14315.
MLA Handbook (7th Edition):
Kaifi, Reham Essam. “Monitoring dynamically the gelation phase transition of agarose with diffusion QMRI as a function of temperature at 3T.” 2014. Web. 20 Jan 2020.
Vancouver:
Kaifi RE. Monitoring dynamically the gelation phase transition of agarose with diffusion QMRI as a function of temperature at 3T. [Internet] [Masters thesis]. Boston University; 2014. [cited 2020 Jan 20].
Available from: http://hdl.handle.net/2144/14315.
Council of Science Editors:
Kaifi RE. Monitoring dynamically the gelation phase transition of agarose with diffusion QMRI as a function of temperature at 3T. [Masters Thesis]. Boston University; 2014. Available from: http://hdl.handle.net/2144/14315
Boston University
13.
Banaja, Duaa.
Improved detection and characterization of obscured central gland tumors of the prostate: texture analysis of non contrast and contrast enhanced MR images for differentiation of benign prostate hyperplasia (BPH) nodules and cancer.
Degree: MS, Bioimaging, 2016, Boston University
URL: http://hdl.handle.net/2144/19200
► OBJECTIVE: The purpose of this study to assess the value of texture analysis (TA) for prostate cancer (PCa) detection on T2 weighted images (T2WI) and…
(more)
▼ OBJECTIVE: The purpose of this study to assess the value of texture analysis (TA) for prostate cancer (PCa) detection on T2 weighted images (T2WI) and dynamic contrast-enhanced images (DCE) by differentiating between the PCa and Benign Prostate Hyperplasia (BPH).
MATERIALS & METHODS: This study used 10 retrospective MRI data sets that were acquired from men with confirmed PCa. The prostate region of interest (ROI) was delineated by an expert on MRI data sets using automated prostate capsule segmentation scheme. The statistical significance test was used for feature selection scheme for optimal differentiation of PCa from BPH on MR images. In pre-processing, for T2-WI, Bias correction and all images intensities are standardized to a representative template. For DCE images, Bias correction and all images are registered to time point 1 for that patient. Following pre-processing texture, features from ROI were extracted and analyzed. Texture features that were extracted are: Intensity mean and standard deviation, Sobel (Edge detection), Haralick features, and Gabor features.
RESULTS: In T2-WI, statistically significant differences were observed in Haralick features. In DCE images, statistically significant differences were observed in mean intensity, Sobel, Gabor, and Haralick features.
CONCLUSION: BPH is better differentiated in DCE images compared to T2-WI. The statically significant features may be combined to build a BPH vs. cancer detection system in future.
Subjects/Keywords: Medical imaging
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APA ·
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MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Banaja, D. (2016). Improved detection and characterization of obscured central gland tumors of the prostate: texture analysis of non contrast and contrast enhanced MR images for differentiation of benign prostate hyperplasia (BPH) nodules and cancer. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/19200
Chicago Manual of Style (16th Edition):
Banaja, Duaa. “Improved detection and characterization of obscured central gland tumors of the prostate: texture analysis of non contrast and contrast enhanced MR images for differentiation of benign prostate hyperplasia (BPH) nodules and cancer.” 2016. Masters Thesis, Boston University. Accessed January 20, 2020.
http://hdl.handle.net/2144/19200.
MLA Handbook (7th Edition):
Banaja, Duaa. “Improved detection and characterization of obscured central gland tumors of the prostate: texture analysis of non contrast and contrast enhanced MR images for differentiation of benign prostate hyperplasia (BPH) nodules and cancer.” 2016. Web. 20 Jan 2020.
Vancouver:
Banaja D. Improved detection and characterization of obscured central gland tumors of the prostate: texture analysis of non contrast and contrast enhanced MR images for differentiation of benign prostate hyperplasia (BPH) nodules and cancer. [Internet] [Masters thesis]. Boston University; 2016. [cited 2020 Jan 20].
Available from: http://hdl.handle.net/2144/19200.
Council of Science Editors:
Banaja D. Improved detection and characterization of obscured central gland tumors of the prostate: texture analysis of non contrast and contrast enhanced MR images for differentiation of benign prostate hyperplasia (BPH) nodules and cancer. [Masters Thesis]. Boston University; 2016. Available from: http://hdl.handle.net/2144/19200
Boston University
14.
Cheng, Anh-Dao M.
Optic nerve atrophy: a comparison of two imaging modalities to evaluate their sensitivity for diagnostic purposes.
Degree: MS, Medical Sciences, 2017, Boston University
URL: http://hdl.handle.net/2144/23757
► PURPOSE: To evaluate the efficacy of MRI as a diagnostic tool by comparing it to OCT in patients with suspected optic nerve atrophy. Currently, MRI…
(more)
▼ PURPOSE: To evaluate the efficacy of MRI as a diagnostic tool by comparing it to OCT in patients with suspected optic nerve atrophy. Currently, MRI is an established noninvasive imaging modality for tumors and inflammatory tissues; however their use in optic nerve atrophy is limited to advanced cases. Our study investigates the use of OCT, a more sensitive imaging modality, compared to MRI as a potential adjunct to the clinical diagnosis of optic nerve atrophy.
METHODS: This retrospective study analyzed 27 medical records (40 eyes) of patients with suspected optic nerve atrophy referred to the Neuro-ophthalmology Clinic of the Beth Israel Deaconess Medical Center (2009-2016) who had both MR imaging of the orbits and SD-OCT scans. Based on the RNFL thickness obtained from OCT scans, optic atrophy was defined as border, mild, moderate, or severe. MRIs were used to measure the optic nerve area, optic nerve diameter and sheath area of all eyes. From there, the ratio of optic nerve area to sheath area, percent difference in optic nerve diameters in a patient and percent difference in optic nerve areas in a patient were determined.
RESULTS: As atrophy worsens, the optic nerve area and sheath area seem to steadily decline. The ratio between the two seems to remain constant (0.27) regardless of degree of atrophy. Focusing on unilateral patients, the percent difference in optic nerve area with mild optic atrophy seemed minimal (14%). It becomes more significant in moderate and severe atrophy cases (56.06% and 26.18% respectively). Overall, there does not seem to be a strong correlation between MRI measurements and OCT RNFL values.
CONCLUSIONS: Overall, a strong correlation was not found between MRI measurements and OCT RNFL thickness values. While a general trend existed, there was too much variation to determine cut off points for atrophy based solely on the measurement of a single eye. MRI may be useful in identifying severe and moderate optic nerve atrophy especially in unilateral patients. Once the RNFL thins to about 70 μm, the difference in size is detectable on MRI. For all cases of mild optic atrophy and bilateral moderate atrophy, OCT remains a more reliable imaging diagnostic. Changes in nerve size appear minimal compared to a healthy human. The optic nerve sheath was also shown to decrease in size in cases of atrophy. Future studies with a larger sample size are needed to produce more conclusive results.
Subjects/Keywords: Medical imaging
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APA (6th Edition):
Cheng, A. M. (2017). Optic nerve atrophy: a comparison of two imaging modalities to evaluate their sensitivity for diagnostic purposes. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/23757
Chicago Manual of Style (16th Edition):
Cheng, Anh-Dao M. “Optic nerve atrophy: a comparison of two imaging modalities to evaluate their sensitivity for diagnostic purposes.” 2017. Masters Thesis, Boston University. Accessed January 20, 2020.
http://hdl.handle.net/2144/23757.
MLA Handbook (7th Edition):
Cheng, Anh-Dao M. “Optic nerve atrophy: a comparison of two imaging modalities to evaluate their sensitivity for diagnostic purposes.” 2017. Web. 20 Jan 2020.
Vancouver:
Cheng AM. Optic nerve atrophy: a comparison of two imaging modalities to evaluate their sensitivity for diagnostic purposes. [Internet] [Masters thesis]. Boston University; 2017. [cited 2020 Jan 20].
Available from: http://hdl.handle.net/2144/23757.
Council of Science Editors:
Cheng AM. Optic nerve atrophy: a comparison of two imaging modalities to evaluate their sensitivity for diagnostic purposes. [Masters Thesis]. Boston University; 2017. Available from: http://hdl.handle.net/2144/23757
Boston University
15.
Diamse, Matthew Rey.
Alzheimer's-like pathology features in brains of rabbits with inflamed aortic atherosclerotic plaques.
Degree: MS, Nutrition and Metabolism, 2019, Boston University
URL: http://hdl.handle.net/2144/36540
► With the continual growth of the average age of the population and the global rise in obesity, it is important to investigate age related cognitive…
(more)
▼ With the continual growth of the average age of the population and the global rise
in obesity, it is important to investigate age related cognitive decline and its many related
risk factors. Alzheimer’s Disease is the most common cause of dementia and has been
linked to another inflammation-associated disease, atherosclerosis. In our lab’s recent
findings, we have demonstrated this mechanistic link between inflammation and
atherosclerosis with specialized pro-resolving mediators, such as lipoxin and resolvin
found in Omega-3 fatty acids. Here we investigated the viability of our rabbit model of
atherosclerosis as a model of Alzheimer’s Disease, in an effort to eventually test the
impact of inflammation resolution as a treatment to AD. We developed and optimized an
MRI protocol as a way to demonstrate and quantify the effect of vascular inflammation
on a brain ex vivo in first a murine model of arterial stiffness. We then applied the refined
protocol for use on our rabbit model of atherosclerosis. The mouse brains induced with
arterial stiffness showed a significant increase of cerebral microbleeds (indicators of
cerebral amyloid angiopathy). Some of the rabbit brains used for this study were found to
be preserved for too long but found good images in recently harvested and perfused
rabbit brains. While the our findings are currently inconclusive, this thesis proposes a
novel method for investigating the mechanistic and synergistic link between
inflammation, atherosclerosis, and Alzheimer’s Disease.
Advisors/Committee Members: Hamilton, James A. (advisor), Deeney, Jude T. (advisor).
Subjects/Keywords: Medical imaging
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APA ·
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APA (6th Edition):
Diamse, M. R. (2019). Alzheimer's-like pathology features in brains of rabbits with inflamed aortic atherosclerotic plaques. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/36540
Chicago Manual of Style (16th Edition):
Diamse, Matthew Rey. “Alzheimer's-like pathology features in brains of rabbits with inflamed aortic atherosclerotic plaques.” 2019. Masters Thesis, Boston University. Accessed January 20, 2020.
http://hdl.handle.net/2144/36540.
MLA Handbook (7th Edition):
Diamse, Matthew Rey. “Alzheimer's-like pathology features in brains of rabbits with inflamed aortic atherosclerotic plaques.” 2019. Web. 20 Jan 2020.
Vancouver:
Diamse MR. Alzheimer's-like pathology features in brains of rabbits with inflamed aortic atherosclerotic plaques. [Internet] [Masters thesis]. Boston University; 2019. [cited 2020 Jan 20].
Available from: http://hdl.handle.net/2144/36540.
Council of Science Editors:
Diamse MR. Alzheimer's-like pathology features in brains of rabbits with inflamed aortic atherosclerotic plaques. [Masters Thesis]. Boston University; 2019. Available from: http://hdl.handle.net/2144/36540
University of California – San Francisco
16.
Li, Elizabeth.
ADC as an early indicator of breast cancer response to neoadjuvant treatment.
Degree: Biomedical Imaging, 2015, University of California – San Francisco
URL: http://www.escholarship.org/uc/item/5vj2714t
► Quantitative MRI can accelerate drug development by providing non-invasive methods to determine treatment response. The primary aim of this study is to assess the change…
(more)
▼ Quantitative MRI can accelerate drug development by providing non-invasive methods to determine treatment response. The primary aim of this study is to assess the change in normalized apparent diffusion coefficient values (ΔADCN), derived from diffusion-weighted MRI (DWI), as an alternative method to standard dynamic contrast-enhanced (DCE) MRI for assessing response of primary breast tumors to neoadjuvant chemotherapy. Secondary aims are to: assess the influence of image quality scoring on the predictive performance of ΔADCN; test correlations between ΔADCN and change in functional tumor volume (ΔFTV) at early (ΔFTV2) and late (ΔFTV4) time points; and assess ΔADCN of responders versus non-responders. Methods: 134 patients with primary breast cancers 2.5 cm in diameter and high MammaPrint scores were included. 62 and 72 patients received standard and experimental drug regimens respectively. ΔADCN was determined from DW images acquired at baseline and three weeks into chemotherapy. FTV (70% DCE-MRI enhancement at 2.5 minutes post-contrast) was used as an indication of tumor response throughout treatment. Pathologic complete response (pCR) was determined by histopathology following surgery. Whole tumor regions of interest (ROIs) and quality scoring was performed on 126 cases, of which 102 had passing quality scores. Results: The area under the receiver operating characteristic (ROC) curve (AUC) for ΔADCN was 0.653 (95% confidence interval (CI) [0.538, 0.768], p=0.00605). The estimated AUC for ΔFTV2 was not significantly higher than ΔADCN (mean difference: -0.011±0.086, p=0.896). Using a ΔFTV4 cutoff of -97.8% as a surrogate endpoint, the AUC estimates were not significantly greater than 0.5. Image quality did not impact the predictive ability or distribution of ΔADCN, which increased by 0.836% (95% CI [-0.48, 0.026], p=0.34) with quality scoring. ΔADCN was not very correlated with ΔFTV2 or ΔFTV4. ΔADCN increased by 9.74% (95% CI [2.24, 17.51], p=0.012) with response in the full cohort. Summary: These findings suggest that ΔADCN may be similar to ΔFTV2 in predictive performance. While changes in ADC and FTV both reflect changes in tissue properties, they are indicative of independent biological processes. DWI is a promising non-contrast technique that can provide additional information to better predict treatment response.
Subjects/Keywords: Medical imaging
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APA (6th Edition):
Li, E. (2015). ADC as an early indicator of breast cancer response to neoadjuvant treatment. (Thesis). University of California – San Francisco. Retrieved from http://www.escholarship.org/uc/item/5vj2714t
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Li, Elizabeth. “ADC as an early indicator of breast cancer response to neoadjuvant treatment.” 2015. Thesis, University of California – San Francisco. Accessed January 20, 2020.
http://www.escholarship.org/uc/item/5vj2714t.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Li, Elizabeth. “ADC as an early indicator of breast cancer response to neoadjuvant treatment.” 2015. Web. 20 Jan 2020.
Vancouver:
Li E. ADC as an early indicator of breast cancer response to neoadjuvant treatment. [Internet] [Thesis]. University of California – San Francisco; 2015. [cited 2020 Jan 20].
Available from: http://www.escholarship.org/uc/item/5vj2714t.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Li E. ADC as an early indicator of breast cancer response to neoadjuvant treatment. [Thesis]. University of California – San Francisco; 2015. Available from: http://www.escholarship.org/uc/item/5vj2714t
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – San Francisco
17.
Avadiappan, Sivakami.
Simultaneous Visualization of Arteries, Veins, and Cerebral Microbleeds from 7T MRA-SWI Images for Assessing the Effects of Radiation Therapy on the Brain.
Degree: Biomedical Imaging, 2017, University of California – San Francisco
URL: http://www.escholarship.org/uc/item/9gn6c0h0
► The use of radiation therapy for treatment of brain tumor is controversial due to its long-term effects on neurocognitive function, especially in pediatric patients. Developing…
(more)
▼ The use of radiation therapy for treatment of brain tumor is controversial due to its long-term effects on neurocognitive function, especially in pediatric patients. Developing objective criteria for evaluating the severity of radiation-related injury is critical for children, due to their longer survival times and impact on early cognitive development. Cerebral microbleeds (CMB) which are deposits of hemosiderin that initially accumulate around vessels and can appear as early as 6 months post radiation therapy and continue to increase in number over time, however their vascular etiology is unknown. The aim of this project is to develop a method for simultaneous visualization of arteries, veins, and CMBs in order to automatically calculate vascular metrics from the fusion of MRA and SWI images obtained from a multi echo sequence at 7 Tesla. A strategy to assess the distribution of CMB’s relative to surrounding arteries and veins would help establish a connection between CMB formation and underlying vascular pathology. The tools developed in this study will be evaluated in pediatric patients with CMBs who have been treated with uniform supratentorial cranial radiation therapy for childhood brain tumors in order to ultimately determine whether metrics describing vascular structure could serve as quantitative markers for radiation injury, help in identifying regions of the brain that are most susceptible to radiation, and predict the formation of new CMBs and subsequent cognitive impairment.
Subjects/Keywords: Medical imaging
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APA (6th Edition):
Avadiappan, S. (2017). Simultaneous Visualization of Arteries, Veins, and Cerebral Microbleeds from 7T MRA-SWI Images for Assessing the Effects of Radiation Therapy on the Brain. (Thesis). University of California – San Francisco. Retrieved from http://www.escholarship.org/uc/item/9gn6c0h0
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Avadiappan, Sivakami. “Simultaneous Visualization of Arteries, Veins, and Cerebral Microbleeds from 7T MRA-SWI Images for Assessing the Effects of Radiation Therapy on the Brain.” 2017. Thesis, University of California – San Francisco. Accessed January 20, 2020.
http://www.escholarship.org/uc/item/9gn6c0h0.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Avadiappan, Sivakami. “Simultaneous Visualization of Arteries, Veins, and Cerebral Microbleeds from 7T MRA-SWI Images for Assessing the Effects of Radiation Therapy on the Brain.” 2017. Web. 20 Jan 2020.
Vancouver:
Avadiappan S. Simultaneous Visualization of Arteries, Veins, and Cerebral Microbleeds from 7T MRA-SWI Images for Assessing the Effects of Radiation Therapy on the Brain. [Internet] [Thesis]. University of California – San Francisco; 2017. [cited 2020 Jan 20].
Available from: http://www.escholarship.org/uc/item/9gn6c0h0.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Avadiappan S. Simultaneous Visualization of Arteries, Veins, and Cerebral Microbleeds from 7T MRA-SWI Images for Assessing the Effects of Radiation Therapy on the Brain. [Thesis]. University of California – San Francisco; 2017. Available from: http://www.escholarship.org/uc/item/9gn6c0h0
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Toledo Health Science Campus
18.
Alarady, Mamdooh R.
Characterization of Image Quality between Multi-Slice
Computed Tomography and Cone Beam Computed Tomography for Clinical
Used Protocols in Radiation Therapy Treatment Planning.
Degree: MSBS, Biomedical Sciences (Medical Physics: Radiation
Oncology), 2017, University of Toledo Health Science Campus
URL: http://rave.ohiolink.edu/etdc/view?acc_num=mco151080400269082
► From diagnosis to treatment and continuous monitoring, imaging is one of the most important steps of cancer treatment. Diagnostic imaging is a useful tool that…
(more)
▼ From diagnosis to treatment and continuous monitoring,
imaging is one of the most important steps of cancer treatment.
Diagnostic
imaging is a useful tool that allows healthcare
professionals to obtain anatomical and physiological information
from patients’ in a non-invasive way. In Radiation Oncology, x-ray
imaging is used to calculate the anatomical radiation dose as well
as it can be a tool for assessing correct positioning of a patient
through a treatment course. Image quality is a key factor in the
process of cancer patient care for all the treatment team.
Radiation Oncologists use Computed Tomography (CT) images to
identify a tumor and delineate a target for radiation therapy
planning.
Medical Physicists fuse CT images with images from other
modalities such as MRI to help physicians in tumor anatomy
contouring. The physicists also use the CT images for radiation
treatment planning. Radiation Therapists use CT images to
accurately position patients prior to radiation therapy sessions.
Due to its importance in Radiation Oncology, the quality control of
imaging systems is commonly incorporated into the quality assurance
program in Radiation Oncology.This research has characterized the
differences in image quality between two
imaging modalities, Fan
Beam CT (FBCT) and Cone Beam CT (CBCT). For the three scanners that
we have in the University of Toledo Dana cancer center, two CBCT,
Varian True Beam OBI CBCT and Varian Edge OBI CBCT, and one FBCT,
Philips Gemini TF Big Bore PET/CT, were used for this study. We
analyzed image quality using several routine scanning protocols on
the three
imaging systems. Seven parameters of image quality have
been evaluated; slice thickness, spatial linearity, CT number
accuracy, spatial resolution, low contrast detectability,
contrast-to-noise ratio (CNR) and image uniformity. All tests were
conducted using the Catphan-504 phantom. Image analysis was done
using two methods, automated software and manual analysis. The
automated software was RIT software (version 6.6) while the manual
analysis was done using a software called MIM software (version
5.6). The comparison showed a similarity in all parameters except
of the low contrast detectability, where the FBCT was superior to
the CBCT. The latter finding may be attributed to the excess
scattered radiation at the detector in CBCT, which in turn
increases the noise and degrades the low contrast
detectability.
Advisors/Committee Members: Parsai, E. Ishmael (Committee Chair).
Subjects/Keywords: Medical Imaging; Physics
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APA (6th Edition):
Alarady, M. R. (2017). Characterization of Image Quality between Multi-Slice
Computed Tomography and Cone Beam Computed Tomography for Clinical
Used Protocols in Radiation Therapy Treatment Planning. (Masters Thesis). University of Toledo Health Science Campus. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=mco151080400269082
Chicago Manual of Style (16th Edition):
Alarady, Mamdooh R. “Characterization of Image Quality between Multi-Slice
Computed Tomography and Cone Beam Computed Tomography for Clinical
Used Protocols in Radiation Therapy Treatment Planning.” 2017. Masters Thesis, University of Toledo Health Science Campus. Accessed January 20, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=mco151080400269082.
MLA Handbook (7th Edition):
Alarady, Mamdooh R. “Characterization of Image Quality between Multi-Slice
Computed Tomography and Cone Beam Computed Tomography for Clinical
Used Protocols in Radiation Therapy Treatment Planning.” 2017. Web. 20 Jan 2020.
Vancouver:
Alarady MR. Characterization of Image Quality between Multi-Slice
Computed Tomography and Cone Beam Computed Tomography for Clinical
Used Protocols in Radiation Therapy Treatment Planning. [Internet] [Masters thesis]. University of Toledo Health Science Campus; 2017. [cited 2020 Jan 20].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=mco151080400269082.
Council of Science Editors:
Alarady MR. Characterization of Image Quality between Multi-Slice
Computed Tomography and Cone Beam Computed Tomography for Clinical
Used Protocols in Radiation Therapy Treatment Planning. [Masters Thesis]. University of Toledo Health Science Campus; 2017. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=mco151080400269082
Wayne State University
19.
Price, Ryan Glen.
Toward magnetic resonance only treatment planning| Distortion mitigation and image-guided radiation therapy validation.
Degree: 2016, Wayne State University
URL: http://pqdtopen.proquest.com/#viewpdf?dispub=10153444
► While MR-only treatment planning has shown promise, there are still several well-known challenges that are currently limiting widespread clinical implementation. Firstly, MR images are…
(more)
▼ While MR-only treatment planning has shown promise, there are still several well-known challenges that are currently limiting widespread clinical implementation. Firstly, MR images are affected by both patient-induced and system-level geometric distortions that can significantly degrade treatment planning accuracy. In addition, the availability of comprehensive distortion analysis software is currently limited. Also while many groups have been working toward a synthetic CT solution, further study is needed on the implementation of synCTs as the reference datasets for linac-based image-guided radiation therapy (IGRT) to help determine their robustness in an MR-only workflow. To determine candidate materials for phantom and software development, 1.0 T MR and CT images were acquired of twelve urethane foam samples of various densities and strengths. Samples were precision machined to accommodate 6 mm diameter paintballs used as landmarks. Final material candidates were selected by balancing strength, machinability, weight, and cost. Bore sizes and minimum aperture width resulting from couch position were tabulated from the literature. Bore geometry and couch position were simulated using MATLAB to generate machine-specific models to optimize the phantom build. Previously developed software for distortion characterization was modified for several magnet geometries, compared against previously published 1.0 T results, and integrated into the 3DSlicer application platform. To evaluate the performance of synthetic CTs in an image guided workflow, magnetic resonance simulation and CT simulation images were acquired of an anthropomorphic skull phantom and 12 patient brain cancer cases. SynCTs were generated using fluid attenuation inversion recovery, ultrashort echo time, and Dixon data sets through a voxel-based weighted summation of 5 tissue classifications. The DRRs were generated from the phantom synCT, and geometric fidelity was assessed relative to CT-generated DRRs through bounding box and landmark analysis. An offline retrospective analysis was conducted to register cone beam CTs to synCTs and CTs using automated rigid registration in the treatment planning system. Planar MV and KV images were rigidly registered to synCT and CT DRRs using an in-house script. Planar and volumetric registration reproducibility was assessed and margin differences were characterized by the van Herk formalism. Over the sampled FOV, non-negligible residual gradient distortions existed as close as 9.5 cm from isocenter, with a maximum distortion of 7.4mm as close as 23 cm from isocenter. Over 6 months, average gradient distortions were -0.07±1.10 mm and 0.10±1.10 mm in the x and y-directions for the transverse plane, 0.03±0.64 and -0.09±0.70 mm in the sagittal plane, and 0.4±1.16 and 0.04±0.40 mm in the coronal plane. After implementing 3D correction maps, distortions were reduced to < 1 pixel width (1mm) for all voxels up to 25 cm from magnet isocenter. …
Subjects/Keywords: Medical imaging; Oncology
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CSE |
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to Zotero / EndNote / Reference
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APA (6th Edition):
Price, R. G. (2016). Toward magnetic resonance only treatment planning| Distortion mitigation and image-guided radiation therapy validation. (Thesis). Wayne State University. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=10153444
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Price, Ryan Glen. “Toward magnetic resonance only treatment planning| Distortion mitigation and image-guided radiation therapy validation.” 2016. Thesis, Wayne State University. Accessed January 20, 2020.
http://pqdtopen.proquest.com/#viewpdf?dispub=10153444.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Price, Ryan Glen. “Toward magnetic resonance only treatment planning| Distortion mitigation and image-guided radiation therapy validation.” 2016. Web. 20 Jan 2020.
Vancouver:
Price RG. Toward magnetic resonance only treatment planning| Distortion mitigation and image-guided radiation therapy validation. [Internet] [Thesis]. Wayne State University; 2016. [cited 2020 Jan 20].
Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10153444.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Price RG. Toward magnetic resonance only treatment planning| Distortion mitigation and image-guided radiation therapy validation. [Thesis]. Wayne State University; 2016. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10153444
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Case Western Reserve University
20.
Barron, Nicholas Henry.
An Analysis of an Advanced Software Business Model for
Magnetic Resonance Imaging Data Post Processing.
Degree: MSs, Physics, 2016, Case Western Reserve University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1459422647
► Over the past few decades, many of the most significant contributions to the field ofmagnetic resonance imaging have been made by Dr. E. Mark Haacke,…
(more)
▼ Over the past few decades, many of the most
significant contributions to the field ofmagnetic resonance
imaging
have been made by Dr. E. Mark Haacke, his collaborators, andmost
recently his company. In 1994, Dr. Haacke founded Magnetic
Resonance InnovationsInc., which now creates software for advanced
MRI postprocessing, DICOM viewersoftware, sequence design, and
more. The company is in the process of pivoting toward adirect
sales business model to hospitals and
imaging centers. This paper
will present multiplemodels concerning revenue, staffing, and
investment strategies being considered for theimmediate future. It
is the opinion of the author that assuming key milestones are
reached,executive staffing needs are satisfied, and clinical
research supporting the need for advancedanalysis continues, that
the proposed business plan accurately represents the future of
thecompany, specifically reaching over $20MM in revenue selling
software to hospitals andimaging centers within five
years.
Advisors/Committee Members: Caner, Edward (Committee Chair).
Subjects/Keywords: Medical Imaging; Entrepreneurship
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APA ·
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to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Barron, N. H. (2016). An Analysis of an Advanced Software Business Model for
Magnetic Resonance Imaging Data Post Processing. (Masters Thesis). Case Western Reserve University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1459422647
Chicago Manual of Style (16th Edition):
Barron, Nicholas Henry. “An Analysis of an Advanced Software Business Model for
Magnetic Resonance Imaging Data Post Processing.” 2016. Masters Thesis, Case Western Reserve University. Accessed January 20, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case1459422647.
MLA Handbook (7th Edition):
Barron, Nicholas Henry. “An Analysis of an Advanced Software Business Model for
Magnetic Resonance Imaging Data Post Processing.” 2016. Web. 20 Jan 2020.
Vancouver:
Barron NH. An Analysis of an Advanced Software Business Model for
Magnetic Resonance Imaging Data Post Processing. [Internet] [Masters thesis]. Case Western Reserve University; 2016. [cited 2020 Jan 20].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1459422647.
Council of Science Editors:
Barron NH. An Analysis of an Advanced Software Business Model for
Magnetic Resonance Imaging Data Post Processing. [Masters Thesis]. Case Western Reserve University; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1459422647
McMaster University
21.
Zheng, Xiaoqing.
INVESTIGATION OF CADMIUM ZINC TELLURIDE DETECTOR FOR MEDICAL IMAGING APPLICATIONS.
Degree: PhD, 2017, McMaster University
URL: http://hdl.handle.net/11375/23880
► The wide band gap semiconductor Cadmium Zinc Telluride (CZT) is of recent interest for medical imaging at room temperature. A number of properties, including superior…
(more)
▼ The wide band gap semiconductor Cadmium Zinc Telluride (CZT) is of recent
interest for medical imaging at room temperature. A number of properties, including
superior energy resolution, 3D photon position sensitivity, compact size, direct
photon conversion and energy-resolving capability, make CZT a promising candidate
for positron emission tomography (PET) and photon-counting X-ray imaging systems.
Despite these advantages, drawbacks, such as low mobility of holes, hole trapping,
charge sharing effect and characteristic X-ray escape degrade the performance of
large volume CZT detectors.
In this research, characterization and evaluation of single-crystal CZT photon
detector using simulation and experimental studies were done. First, a comprehensive
analytical model was developed and implemented by using Monte Carlo simulation
and finite element analyses. This model includes the generation and transportation of
charge carries within CZT detectors, and it provides useful guidance in optimizing the
electrode design and associated readout circuits.
Second, the performance of a 20×20×5mm3
CZT crystal with 8×8 pixel anodes
and a planar cathode was integrated with readout electronics that can be used to build
a PET system was studied. The experiments demonstrate an energy resolution of
~2.26±0.84% full width half maximum (FWHM) at 662 keV and 19±3 ns
coincidence time resolution with planar parallel field configuration. A novel
algorithm based on charge sharing effect and transient signal analysis targeting the
improvement of spatial resolution, was proposed. The sub-pitch spatial resolution is
found to be ~30 µm and ~250 µm under signal-to-noise ratio of ~17, for inside and
outside the valid range of charge sharing, respectively.
Finally, the feasibility of CZT in photon-counting Computed Tomography (CT)
was studied by using monoenergetic sources, with a special attention paid to energy
degradation due to characteristic X-ray escape and the charge sharing effect. The
effects of detector configuration and incident beam location were also investigated.
The results show that the pixel size can be reduced to 500 µm without significant
count loss (~5%) and charge loss (~15%) for the photo-counting X-ray applications.
Thesis
Doctor of Philosophy (PhD)
Advisors/Committee Members: Deen, M. Jamal, Electrical and Computer Engineering.
Subjects/Keywords: CZT; Medical Imaging
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to Zotero / EndNote / Reference
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APA (6th Edition):
Zheng, X. (2017). INVESTIGATION OF CADMIUM ZINC TELLURIDE DETECTOR FOR MEDICAL IMAGING APPLICATIONS. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/23880
Chicago Manual of Style (16th Edition):
Zheng, Xiaoqing. “INVESTIGATION OF CADMIUM ZINC TELLURIDE DETECTOR FOR MEDICAL IMAGING APPLICATIONS.” 2017. Doctoral Dissertation, McMaster University. Accessed January 20, 2020.
http://hdl.handle.net/11375/23880.
MLA Handbook (7th Edition):
Zheng, Xiaoqing. “INVESTIGATION OF CADMIUM ZINC TELLURIDE DETECTOR FOR MEDICAL IMAGING APPLICATIONS.” 2017. Web. 20 Jan 2020.
Vancouver:
Zheng X. INVESTIGATION OF CADMIUM ZINC TELLURIDE DETECTOR FOR MEDICAL IMAGING APPLICATIONS. [Internet] [Doctoral dissertation]. McMaster University; 2017. [cited 2020 Jan 20].
Available from: http://hdl.handle.net/11375/23880.
Council of Science Editors:
Zheng X. INVESTIGATION OF CADMIUM ZINC TELLURIDE DETECTOR FOR MEDICAL IMAGING APPLICATIONS. [Doctoral Dissertation]. McMaster University; 2017. Available from: http://hdl.handle.net/11375/23880
University of California – San Francisco
22.
Yu, Justin.
Optimization of pH Imaging Methodology for Hyperpolarized 13C MRI.
Degree: Biomedical Imaging, 2017, University of California – San Francisco
URL: http://www.escholarship.org/uc/item/8cv2m04w
► Background: The acidification of the tumor microenvironment is a result of extensivemetabolic reprogramming in cancer cells and is linked with tumor metastasis. HyperpolarizedMRI is a…
(more)
▼ Background: The acidification of the tumor microenvironment is a result of extensivemetabolic reprogramming in cancer cells and is linked with tumor metastasis. HyperpolarizedMRI is a method for imaging and quantifying this change in pH, but suffers from rapid signalloss from spin-lattice (T1) relaxation. We propose using hydrogen/deuterium exchange onhyperpolarized 13C probes in order to prolong hyperpolarized signal by reducing T1 relaxation.Methods: H/D exchange was performed on several amino acids and amino acid derivativeswith utility in HP-MRI. Isotopic enrichment was evaluated using 1H NMR. The T1 relaxationconstant was quantified by analyzing the decay of hyperpolarized signal of deuterated vs nondeuterated 13C compounds. Results: H/D exchange was successfully used to enrich compoundswith deuterium with high isotopic enrichment and moderate to high chemical yield. The T1relaxation constant of all fully analyzed 13C compounds exhibited a significant increase afterdeuteration at 3T: T1 of 13C Gly increased from 52.0±3.2 to 65.0±1.2s, 13C Ala from 52.9±2.2to 66.4±1.7s, 13C Val from 38.1±1.1 to 49.2±0.4s. Conclusion: H/D exchange methoddescribed is a viable technique for inexpensive and direct deuterium labeling. Deuteriumlabeling be applied to hyperpolarized 13C MRI probes to prolong HP signal by lengthening T1.
Subjects/Keywords: Medical imaging; Chemistry
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APA (6th Edition):
Yu, J. (2017). Optimization of pH Imaging Methodology for Hyperpolarized 13C MRI. (Thesis). University of California – San Francisco. Retrieved from http://www.escholarship.org/uc/item/8cv2m04w
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Yu, Justin. “Optimization of pH Imaging Methodology for Hyperpolarized 13C MRI.” 2017. Thesis, University of California – San Francisco. Accessed January 20, 2020.
http://www.escholarship.org/uc/item/8cv2m04w.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Yu, Justin. “Optimization of pH Imaging Methodology for Hyperpolarized 13C MRI.” 2017. Web. 20 Jan 2020.
Vancouver:
Yu J. Optimization of pH Imaging Methodology for Hyperpolarized 13C MRI. [Internet] [Thesis]. University of California – San Francisco; 2017. [cited 2020 Jan 20].
Available from: http://www.escholarship.org/uc/item/8cv2m04w.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Yu J. Optimization of pH Imaging Methodology for Hyperpolarized 13C MRI. [Thesis]. University of California – San Francisco; 2017. Available from: http://www.escholarship.org/uc/item/8cv2m04w
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
West Virginia University
23.
Sparks, Ronnie J.
A Comparison of Airway Dimensions among Different Skeletal Craniofacial Patterns.
Degree: MS, Orthodontics, 2012, West Virginia University
URL: https://researchrepository.wvu.edu/etd/4921
► Background and Objectives: Much attention has been given to the association of craniofacial skeletal morphology, upper airway dimension, and respiratory function with patients suffering from…
(more)
▼ Background and Objectives: Much attention has been given to the association of craniofacial skeletal morphology, upper airway dimension, and respiratory function with patients suffering from obstructive sleep apnea. However, much of the information gathered on the aforementioned has been established with the use of 2-Dimensional lateral cephalometry. The objective of this study was to investigate upper airway dimensions among different skeletal patterns using cone-beam computed tomography (CBCT). Methods: A sample of 279 patients who seught orthodontic treatment at the University of Nevada Las Vegas School of Dentistry Department of Orthodontics was included in this study. Pre-treatment multi-slice CBCT scans of these subjects were divided into three sagittal groups: Class I subjects with an ANB angle 0° to 5°, Class II subjects with an ANB angle > 5°, and Class III subjects with an ANB angle < 0°. The CBCT scans were also divided into three vertical groups: normodivergent subjects with a mandibular plane angle 22° to 30°, hyperdivergent subjects with a mandibular plane angle > 30°, and hypodivergent subjects with a mandibular plane angle< 22°. The sagittal and vertical groups were analyzed individually (6 groups) and together (9 groups) to determine if the various combination of skeletal patterns has any effects on airway volume, minimum cross sectional area (CSA), and airway shape. CBCT scans were analyzed using Dolphin
Imaging 10.5 Premium and Anatomage In VivoDental(TM) software version 5.1. Data were analyzed using ANOV A, Tukey-Kramer, Student t test, and Wilcoxon/Kruskal-Wallis tests. Results: Significant differences were found among the sagittal groups for airway volume and minimum CSA, p < .05. Class III subjects were found to have the largest airway volume and minimum CSA while Class II subjects were found to have the smallest airway volume and minimum CSA. Minimum CSA was found to have an increasing function of airway volume. CSA increased by 10.23 mm2 for every cc increase in airway volume. No significant differences were found among the vertical groups. However, Class II subjects with hyperdivergent skeletal pattern were found to have the smallest airway volume and minimum CSA. No associations were found between the airway shapes and airway volume when evaluating sagittal and/or vertical skeletal patterns. However, wide airway shapes were shown to have the largest airway volume while long airway shapes were shown to have the smallest airways. Conclusions: Airway dimensions can be affected by craniofacial skeletal pattern. Patients with Class II hyperdivergent skeletal pattern may be more prone to obstructive sleep apnea problems.
Advisors/Committee Members: Peter Ngan, Chris Martin, Thomas Razmus.
Subjects/Keywords: Dentistry; Medical imaging
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APA (6th Edition):
Sparks, R. J. (2012). A Comparison of Airway Dimensions among Different Skeletal Craniofacial Patterns. (Thesis). West Virginia University. Retrieved from https://researchrepository.wvu.edu/etd/4921
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Sparks, Ronnie J. “A Comparison of Airway Dimensions among Different Skeletal Craniofacial Patterns.” 2012. Thesis, West Virginia University. Accessed January 20, 2020.
https://researchrepository.wvu.edu/etd/4921.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Sparks, Ronnie J. “A Comparison of Airway Dimensions among Different Skeletal Craniofacial Patterns.” 2012. Web. 20 Jan 2020.
Vancouver:
Sparks RJ. A Comparison of Airway Dimensions among Different Skeletal Craniofacial Patterns. [Internet] [Thesis]. West Virginia University; 2012. [cited 2020 Jan 20].
Available from: https://researchrepository.wvu.edu/etd/4921.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Sparks RJ. A Comparison of Airway Dimensions among Different Skeletal Craniofacial Patterns. [Thesis]. West Virginia University; 2012. Available from: https://researchrepository.wvu.edu/etd/4921
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Duke University
24.
Whitley, Melodi Javid.
Preclinical and Clinical Studies of an Investigational Protease-Activated Fluorescent Probe for Cancer Theranostics
.
Degree: 2017, Duke University
URL: http://hdl.handle.net/10161/14350
► Local recurrence is a common cause of treatment failure for patients with solid tumors. Intra-operative detection and selective ablation of microscopic residual cancer in…
(more)
▼ Local recurrence is a common cause of treatment failure for patients with solid tumors. Intra-operative detection and selective ablation of microscopic residual cancer in the tumor bed could be used to decrease the risk of a positive surgical margin, reduce rates of re-excision, and tailor adjuvant therapy, all of which may contribute to improved disease control. Here, we use a protease–activated fluorescent
imaging probe, LUM015, to detect cancer in vivo in a mouse model of soft tissue sarcoma (STS) and ex vivo in a first-in-human Phase I clinical trial. In mice, intravenous injection of LUM015 labeled tumor cells and residual fluorescence detected within the tumor bed predicted local recurrence. In fifteen patients with STS or breast cancer, intravenous injection of LUM015 prior to surgery was well tolerated.
Imaging of resected human tissues showed that fluorescence from tumor was significantly higher than fluorescence from normal tissue. Comparison of LUM015 biodistribution and metabolism in mouse and human subjects revealed similar pharmacokinetic profiles for this PEGylated
imaging probe. The major fluorescent LUM015 metabolite was determined to be Cy5-Lysine. Tissue concentrations of LUM015 and its metabolites demonstrated that LUM015 is selectively distributed to tumors where it is activated by proteases to establish tumor to normal contrast. Experiments in mice with a constitutively active PEGylated fluorescent
imaging probe support a model where tumor-selective probe distribution is a determinant of increased fluorescence in cancer. These co-clinical studies suggest that the tumor-specificity of protease-activated
imaging probes, such as LUM015, is significantly dependent on both biodistribution and protease-activation. These results support future clinical trials of LUM015 in which intraoperative
imaging of the tumor bed is compared to surgical margin histopathology. I also describe a novel pulsed Nd:YAG laser ablation system that, when used in conjunction with LUM015, can identify and ablate cancer in vivo. Mice with primary STS were injected with the protease-activatable probe LUM015 to label tumors. Resected tissues from the mice were then imaged and treated with the laser using the paired fluorescence-
imaging/ laser ablation device, generating ablation clefts with sub-millimeter precision and minimal underlying tissue damage. Laser ablation was guided by fluorescence to target tumor tissues, avoiding normal structures. The selective ablation of tumor implants in vivo improved recurrence-free survival after tumor resection. This prototype system has the potential to be modified so that it can be used during surgery to improve recurrence-free survival in patients with cancer.
Advisors/Committee Members: Kirsch, David G (advisor).
Subjects/Keywords: Oncology;
Medical imaging
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APA (6th Edition):
Whitley, M. J. (2017). Preclinical and Clinical Studies of an Investigational Protease-Activated Fluorescent Probe for Cancer Theranostics
. (Thesis). Duke University. Retrieved from http://hdl.handle.net/10161/14350
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Whitley, Melodi Javid. “Preclinical and Clinical Studies of an Investigational Protease-Activated Fluorescent Probe for Cancer Theranostics
.” 2017. Thesis, Duke University. Accessed January 20, 2020.
http://hdl.handle.net/10161/14350.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Whitley, Melodi Javid. “Preclinical and Clinical Studies of an Investigational Protease-Activated Fluorescent Probe for Cancer Theranostics
.” 2017. Web. 20 Jan 2020.
Vancouver:
Whitley MJ. Preclinical and Clinical Studies of an Investigational Protease-Activated Fluorescent Probe for Cancer Theranostics
. [Internet] [Thesis]. Duke University; 2017. [cited 2020 Jan 20].
Available from: http://hdl.handle.net/10161/14350.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Whitley MJ. Preclinical and Clinical Studies of an Investigational Protease-Activated Fluorescent Probe for Cancer Theranostics
. [Thesis]. Duke University; 2017. Available from: http://hdl.handle.net/10161/14350
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
West Virginia University
25.
Talkington, William James.
Early and Late Stage Mechanisms for Vocalization Processing in the Human Auditory System.
Degree: PhD, Neurology, 2013, West Virginia University
URL: https://researchrepository.wvu.edu/etd/218
► The human auditory system is able to rapidly process incoming acoustic information, actively filtering, categorizing, or suppressing different elements of the incoming acoustic stream. Vocalizations…
(more)
▼ The human auditory system is able to rapidly process incoming acoustic information, actively filtering, categorizing, or suppressing different elements of the incoming acoustic stream. Vocalizations produced by other humans (conspecifics) likely represent the most ethologically-relevant sounds encountered by hearing individuals. Subtle acoustic characteristics of these vocalizations aid in determining the identity, emotional state, health, intent, etc. of the producer. The ability to assess vocalizations is likely subserved by a specialized network of structures and functional connections that are optimized for this stimulus class. Early elements of this network would show sensitivity to the most basic acoustic features of these sounds; later elements may show categorically-selective response patterns that represent high-level semantic organization of different classes of vocalizations. A combination of functional magnetic resonance
imaging and electrophysiological studies were performed to investigate and describe some of the earlier and later stage mechanisms of conspecific vocalization processing in human auditory cortices. Using fMRI, cortical representations of harmonic signal content were found along the middle superior temporal gyri between primary auditory cortices along Heschl's gyri and the superior temporal sulci, higher-order auditory regions. Additionally, electrophysiological findings also demonstrated a parametric response profile to harmonic signal content. Utilizing a novel class of vocalizations, human-mimicked versions of animal vocalizations, we demonstrated the presence of a left-lateralized cortical vocalization processing hierarchy to conspecific vocalizations, contrary to previous findings describing similar bilateral networks. This hierarchy originated near primary auditory cortices and was further supported by auditory evoked potential data that suggests differential temporal processing dynamics of conspecific human vocalizations versus those produced by other species. Taken together, these results suggest that there are auditory cortical networks that are highly optimized for processing utterances produced by the human vocal tract. Understanding the function and structure of these networks will be critical for advancing the development of novel communicative therapies and the design of future assistive hearing devices.
Advisors/Committee Members: James W. Lewis, Albert S. Berrebi, David W. Graham.
Subjects/Keywords: Neurosciences; Medical imaging
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Chicago ·
MLA ·
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CSE |
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to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Talkington, W. J. (2013). Early and Late Stage Mechanisms for Vocalization Processing in the Human Auditory System. (Doctoral Dissertation). West Virginia University. Retrieved from https://researchrepository.wvu.edu/etd/218
Chicago Manual of Style (16th Edition):
Talkington, William James. “Early and Late Stage Mechanisms for Vocalization Processing in the Human Auditory System.” 2013. Doctoral Dissertation, West Virginia University. Accessed January 20, 2020.
https://researchrepository.wvu.edu/etd/218.
MLA Handbook (7th Edition):
Talkington, William James. “Early and Late Stage Mechanisms for Vocalization Processing in the Human Auditory System.” 2013. Web. 20 Jan 2020.
Vancouver:
Talkington WJ. Early and Late Stage Mechanisms for Vocalization Processing in the Human Auditory System. [Internet] [Doctoral dissertation]. West Virginia University; 2013. [cited 2020 Jan 20].
Available from: https://researchrepository.wvu.edu/etd/218.
Council of Science Editors:
Talkington WJ. Early and Late Stage Mechanisms for Vocalization Processing in the Human Auditory System. [Doctoral Dissertation]. West Virginia University; 2013. Available from: https://researchrepository.wvu.edu/etd/218
University of Minnesota
26.
Shapovalova, Mariya.
Molecular Imaging of Prostate Cancer Using Biomarker-Guided Strategies.
Degree: PhD, Pharmacology, 2019, University of Minnesota
URL: http://hdl.handle.net/11299/208849
► Prostate cancer affects 1 in 9 men in their lifetime. While disease that is detected early can be very treatable, recurrence affects about 30% of…
(more)
▼ Prostate cancer affects 1 in 9 men in their lifetime. While disease that is detected early can be very treatable, recurrence affects about 30% of the patients. Imaging is an important tool for detecting and assessing therapeutic regimens for prostate cancer patients. Patients with advanced stages of prostate cancer, typically those who have had a recurrence and are forming resistance to hormone therapy, are in a great need for a more accurate assessment of the extent of their disease for a better understanding of its aggressiveness. Clinical imaging offers physicians information about the location and extent of disease. Unfortunately, conventional imaging methods often lack the sensitivity needed to detect some lesions properly, especially when the disease is no longer localized and has spread outside of the prostate, which leads to insufficient information that is needed for proper diagnosis and treatment planning. Most of the current imaging techniques are not specific for tumor physiological processes. Therefore, a clinical need remains for new imaging agents that can target prostate tumors more specifically and sensitively. My PhD research focused on using molecular-genetic imaging approaches to develop imaging agents in vitro and in vivo that can detect prostate cancer using the cancer's unique regulatory genetic differences from normal cells. I investigated the expression two prostate cancer-specific genes, AMACR and PEG10 and used the genes' unique transcriptional regulations in the prostate cancer cells to induce prostate cancer-specific expression of reporter proteins. Specifically, I used the promoters of AMACR and PEG10 in adenovirus and plasmid DNA vectors upstream of various reporter genes to induce expression of reporter proteins in prostate cancer cells. By using the prostate cancer-specific promoters, I was able to image prostate cancer in vivo using various vectors and different modes of imaging such as bioluminescence/fluorescence and positron emission tomography imaging. My results strongly support that prostate cancer specific promoters can induce prostate cancer specific gene expression and may have the potential to be used for imaging purposes.
Subjects/Keywords: Oncology; Medical imaging
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Shapovalova, M. (2019). Molecular Imaging of Prostate Cancer Using Biomarker-Guided Strategies. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/208849
Chicago Manual of Style (16th Edition):
Shapovalova, Mariya. “Molecular Imaging of Prostate Cancer Using Biomarker-Guided Strategies.” 2019. Doctoral Dissertation, University of Minnesota. Accessed January 20, 2020.
http://hdl.handle.net/11299/208849.
MLA Handbook (7th Edition):
Shapovalova, Mariya. “Molecular Imaging of Prostate Cancer Using Biomarker-Guided Strategies.” 2019. Web. 20 Jan 2020.
Vancouver:
Shapovalova M. Molecular Imaging of Prostate Cancer Using Biomarker-Guided Strategies. [Internet] [Doctoral dissertation]. University of Minnesota; 2019. [cited 2020 Jan 20].
Available from: http://hdl.handle.net/11299/208849.
Council of Science Editors:
Shapovalova M. Molecular Imaging of Prostate Cancer Using Biomarker-Guided Strategies. [Doctoral Dissertation]. University of Minnesota; 2019. Available from: http://hdl.handle.net/11299/208849
University of Washington
27.
Zeng, Geng.
Methods for a dedicated breast cancer scanner combining positron emission tomography (PET) and mammography imaging.
Degree: PhD, 2018, University of Washington
URL: http://hdl.handle.net/1773/43130
► The PET/X breast imaging system is designed to be a compact positron emission tomography (PET) scanner with a rectangular field of view (FOV) that can…
(more)
▼ The PET/X breast
imaging system is designed to be a compact positron emission tomography (PET) scanner with a rectangular field of view (FOV) that can be mounted directly over the conventional mammography scanner. This thesis studies the prototyping of this dedicated breast cancer scanner that combines PET and mammography, using mostly computer modeling methods, while the hardware of data acquisition system is being concurrently developed. Apart from processing scripts and functions, two major simulation software packages are used: SimSET and CatSim. The former models PET emission process and the latter models mammography projection. This thesis delves into the details of using these packages and presents results of applying them to the PET/X system. By studying reconstructed images using simulated PET data, this thesis characterizes the proposed PET/X scanner and estimates its performance upper bound. Under several idealized detector conditions, the PET/X scanner exceeds the design goal of detecting a 20% change of radiotracer concentration with high sensitivity and specificity. This thesis also explores the use of X-ray (mammography) images for necessary attenuation correction of the PET data. Preliminary result shows that the X-ray-based attenuation correction (XAC) method has potential to be a surrogate for ground truth attenuation correction for the PET/X system.
Advisors/Committee Members: Kinahan, Paul E. (advisor).
Subjects/Keywords:
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Zeng, G. (2018). Methods for a dedicated breast cancer scanner combining positron emission tomography (PET) and mammography imaging. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/43130
Chicago Manual of Style (16th Edition):
Zeng, Geng. “Methods for a dedicated breast cancer scanner combining positron emission tomography (PET) and mammography imaging.” 2018. Doctoral Dissertation, University of Washington. Accessed January 20, 2020.
http://hdl.handle.net/1773/43130.
MLA Handbook (7th Edition):
Zeng, Geng. “Methods for a dedicated breast cancer scanner combining positron emission tomography (PET) and mammography imaging.” 2018. Web. 20 Jan 2020.
Vancouver:
Zeng G. Methods for a dedicated breast cancer scanner combining positron emission tomography (PET) and mammography imaging. [Internet] [Doctoral dissertation]. University of Washington; 2018. [cited 2020 Jan 20].
Available from: http://hdl.handle.net/1773/43130.
Council of Science Editors:
Zeng G. Methods for a dedicated breast cancer scanner combining positron emission tomography (PET) and mammography imaging. [Doctoral Dissertation]. University of Washington; 2018. Available from: http://hdl.handle.net/1773/43130
University of Manchester
28.
Armstrong, Ian.
Quantitative Accuracy of Iterative Reconstruction
Algorithms in Positron Emission Tomography.
Degree: 2017, University of Manchester
URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306784
► Positron Emission Tomography (PET) plays an essential role in the management of patients with cancer. It is used to detect and characterise malignancy as well…
(more)
▼ Positron Emission Tomography (PET) plays an
essential role in the management of patients with cancer. It is
used to detect and characterise malignancy as well as monitor
response to therapy. PET is a quantitative
imaging tool, producing
images that quantify the uptake of a radiotracer that has been
administered to the patient. The most common measure of uptake
derived from the image is known as a Standardised Uptake Value
(SUV). Data acquired on the scanner is processed to produce images
that are reported by clinicians. This task is known as image
reconstruction and uses computational algorithms to process the
scan data. The last decade has seen substantial development of
these algorithms, which have become commercially available:
modelling of the scanner spatial resolution (resolution modelling)
and time of flight (TOF). The Biograph mCT was the first scanner
from Siemens Healthcare to feature these two algorithms and the
scanner at Central Manchester University Hospitals was the first
Biograph mCT to go live in the UK. This PhD project, sponsored by
Siemens Healthcare, aims to evaluate the effect of these algorithms
on SUV in routine oncology
imaging through a combination of phantom
and patient studies.Resolution modelling improved visualisation of
small objects and resulted in significant increases of uptake
measurements. This may pose a challenge to clinicians when
interpreting established uptake metrics that are used as an
indication of disease status. Resolution modelling reduced the
variability of SUV. This improved precision is particularly
beneficial when assessing SUV changes during therapy monitoring.TOF
was shown to reduce image noise with a conservation of FDG uptake
measurements, relative to non-TOF algorithms. As a result of this
work, TOF has been used routinely since mid-2014 at the CMUH
department. This has facilitated a reduction of patient and staff
radiation dose and an increase of 100 scans performed each year in
the department.
Advisors/Committee Members: WILLIAMS, HEATHER HA, Williams, Heather, Matthews, Julian.
Subjects/Keywords: Oncology; Medical Imaging; Image Reconstruction; PET imaging
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Armstrong, I. (2017). Quantitative Accuracy of Iterative Reconstruction
Algorithms in Positron Emission Tomography. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306784
Chicago Manual of Style (16th Edition):
Armstrong, Ian. “Quantitative Accuracy of Iterative Reconstruction
Algorithms in Positron Emission Tomography.” 2017. Doctoral Dissertation, University of Manchester. Accessed January 20, 2020.
http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306784.
MLA Handbook (7th Edition):
Armstrong, Ian. “Quantitative Accuracy of Iterative Reconstruction
Algorithms in Positron Emission Tomography.” 2017. Web. 20 Jan 2020.
Vancouver:
Armstrong I. Quantitative Accuracy of Iterative Reconstruction
Algorithms in Positron Emission Tomography. [Internet] [Doctoral dissertation]. University of Manchester; 2017. [cited 2020 Jan 20].
Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306784.
Council of Science Editors:
Armstrong I. Quantitative Accuracy of Iterative Reconstruction
Algorithms in Positron Emission Tomography. [Doctoral Dissertation]. University of Manchester; 2017. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306784
Boston University
29.
Subaran, Sarah Samira.
A visual comparison between the Ultrasound X6-1 Matrix transducer and MRI in lesion detection in the dome of the liver.
Degree: MS, Bioimaging, 2014, Boston University
URL: http://hdl.handle.net/2144/14393
► Imaging the dome of the liver can be a very challenging area to image by Ultrasound. Due to its position inside the ribcage there can…
(more)
▼ Imaging the dome of the liver can be a very challenging area to image by Ultrasound. Due to its position inside the ribcage there can be difficulty with rib shadowing artifacts causing the sonographer to miss small lesions. The X6–1 Matrix transducer is one of the newest of its kind and claims to be the better multi-use transducer. Its larger aperture reduces rib artifacts and is composed of PureWave Crystal Technology. A phantom will serve as a great approach in this abdominal study to visually compare the lesions between MRI (gold standard) and the new X6–1 Matrix Ultrasound transducer. The X6–1 transducers did reveal minimal rib shadowing and the small lesions were identified.
Subjects/Keywords: Medical imaging; Imaging; Liver; MRI; Ultrasound
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Subaran, S. S. (2014). A visual comparison between the Ultrasound X6-1 Matrix transducer and MRI in lesion detection in the dome of the liver. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/14393
Chicago Manual of Style (16th Edition):
Subaran, Sarah Samira. “A visual comparison between the Ultrasound X6-1 Matrix transducer and MRI in lesion detection in the dome of the liver.” 2014. Masters Thesis, Boston University. Accessed January 20, 2020.
http://hdl.handle.net/2144/14393.
MLA Handbook (7th Edition):
Subaran, Sarah Samira. “A visual comparison between the Ultrasound X6-1 Matrix transducer and MRI in lesion detection in the dome of the liver.” 2014. Web. 20 Jan 2020.
Vancouver:
Subaran SS. A visual comparison between the Ultrasound X6-1 Matrix transducer and MRI in lesion detection in the dome of the liver. [Internet] [Masters thesis]. Boston University; 2014. [cited 2020 Jan 20].
Available from: http://hdl.handle.net/2144/14393.
Council of Science Editors:
Subaran SS. A visual comparison between the Ultrasound X6-1 Matrix transducer and MRI in lesion detection in the dome of the liver. [Masters Thesis]. Boston University; 2014. Available from: http://hdl.handle.net/2144/14393
30.
Hilt, Silvia.
Spin Labeled Fluorene Compounds are a Versatile Sword in the Fight Against Amyloid Beta Peptide of Alzheimer's Disease.
Degree: 2016, University of California, Davis
URL: http://pqdtopen.proquest.com/#viewpdf?dispub=10182862
► Amyloid-β (Aβ) peptide is generated after sequential cleavage of the constitutively expressed amyloid precursor protein (APP) by γ and β secretases, and is recognized…
(more)
▼ Amyloid-β (Aβ) peptide is generated after sequential cleavage of the constitutively expressed amyloid precursor protein (APP) by γ and β secretases, and is recognized as the primary causative agent underlying the neuropathogenesis of Alzheimer’sDisease (AD). Once generated, monomeric Aβ demonstrates a high propensity to aggregate into toxic Aβ oligomers (AβO) of various sizes, which eventually accumulate in the brain in the form of amyloid plaques. Mutations in either the gene for APP or one or both of its processing genes, presenilin-1 (PS1) and presenilin-2 (PS2) of the secretases complex leading to accumulation of Aβ and early-onset familial AD. Late onset AD is modulated by mutations in the gene for apolipoprotein E (apo-E), with the isoform apo-E4 leading to an approximate eight-fold increase in risk for AD, and by environmental and life style factors. The Alzheimer’s disease process develops over decades, with substantial neurological loss occurring before a clinical diagnosis of dementia can be rendered. A major roadblock to the management of AD is the inability to definitively diagnose AD until post-mortem examination. It is therefore imperative to develop methods that permit safe, early detection and monitoring of disease progression. Magnetic resonance imaging (MRI) is a non-invasive way to detect and monitor AD progression and therapy, but so far MRI contrast has been obtained only using Gd(III) based contrast agents. Fluorene compounds have garnered attention as amyloid imaging agents. Our lab has developed a spin labeled fluorene (SLF) compound that contains a fluorene moiety with known affinity for Aβ and a pyrroline nitroxyl spin-label moiety. We hypothesized that the SLF compound will specifically coat assemblies of amyloid beta in the brain and, by establishing a boundary of magnetic field inhomogeneity, produce MRI contrast in tissues with elevated levels of the Aβ peptide. I found that labeling of brain specimens with the SLF compound produces negative contrast in samples from AD model mice whereas no negative contrast is seen in specimens harvested from wild-type mice. Injection of SLF into live mice resulted in good brain penetration, with the compound able to generate contrast 24-hr post injection. (Abstract shortened by ProQuest.)
Subjects/Keywords: Neurosciences; Biochemistry; Medical imaging
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
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to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Hilt, S. (2016). Spin Labeled Fluorene Compounds are a Versatile Sword in the Fight Against Amyloid Beta Peptide of Alzheimer's Disease. (Thesis). University of California, Davis. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=10182862
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hilt, Silvia. “Spin Labeled Fluorene Compounds are a Versatile Sword in the Fight Against Amyloid Beta Peptide of Alzheimer's Disease.” 2016. Thesis, University of California, Davis. Accessed January 20, 2020.
http://pqdtopen.proquest.com/#viewpdf?dispub=10182862.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hilt, Silvia. “Spin Labeled Fluorene Compounds are a Versatile Sword in the Fight Against Amyloid Beta Peptide of Alzheimer's Disease.” 2016. Web. 20 Jan 2020.
Vancouver:
Hilt S. Spin Labeled Fluorene Compounds are a Versatile Sword in the Fight Against Amyloid Beta Peptide of Alzheimer's Disease. [Internet] [Thesis]. University of California, Davis; 2016. [cited 2020 Jan 20].
Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10182862.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hilt S. Spin Labeled Fluorene Compounds are a Versatile Sword in the Fight Against Amyloid Beta Peptide of Alzheimer's Disease. [Thesis]. University of California, Davis; 2016. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10182862
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
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Open Access Theses and Dissertations