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University of Manchester
1.
Forbes, Sarah.
Assessment of Apolipoprotein E Derived Peptides as Novel
Antimicrobials for the Coating of Biomedical Devices.
Degree: 2013, University of Manchester
URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:185610 
► The microbial contamination of biomedical devices is a leading cause of hospital- acquired infection. A number of strategies aimed at developing device coatings that are…
(more)
▼ The microbial contamination of biomedical devices
is a leading cause of hospital- acquired infection. A number of
strategies aimed at developing
device coatings that are refractory
to microbial adhesion, colonisation and biofilm formation have been
developed, but the problem remains. The incorporation of biocides
into biomedical
device surface coatings has shown promising results
in preventing the establishment of infection. Current controversy
over the possibility that extensive use of biocides could
potentially lead to antimicrobial resistance has fuelled the search
for new actives with good antimicrobial activity and low
cytotoxicity, that maintain marked efficacy after prolonged use.
This doctoral thesis aims to evaluate the antimicrobial potential
of a novel peptide based on human apolipoprotein E receptor binding
region (apoEdpL-W). The spectrum of antimicrobial activity and
anti-biofilm efficacy of apoEdpL-W was compared to that of common
biocides polyhexamethylene biguanide, triclosan, cetrimide and
chlorhexidine. The potential to induce bacterial insusceptibility
towards these agents after long-term sub-lethal level exposure was
assessed. Initial examination against 18 test microorganisms,
commonly associated with
device infection, showed that apoEdpL-W
displayed broad-range antimicrobial and anti-biofilm efficacy.
ApoEdpL-W also maintained marked antibacterial activity after
incorporation onto various biomaterial polymers, often used in
device surface coatings. Alterations in bacterial susceptibility
after prolonged exposure to apoEdpL-W, as well as to the other
biocides, were often temporary and partially reverted once the
bacteria had been grown in the absence of the antimicrobial agent.
The adaption of Staphylococcus aureus to the presence of triclosan
resulted in the formation of small colony variants (SVCs) with
reduced triclosan susceptibility. Analysis of the physiological
characteristics of the triclosan induced SCVs revealed the loss of
virulence determinants and potentially reduced pathogenic
capability, when compared to the parent strain. The
biocompatibility index values of the test actives were determined
by the parallel assessment of their antibacterial activity and in
vitro cytotoxicity. ApoEdpL-W showed good antibacterial efficacy
whilst remaining relatively less toxic to mammalian cells than
triclosan or chlorhexidine. We studied the interactions of the test
antimicrobials with a preformed phospholipid bilayer using the
quartz crystal microbalance
device and dual polarisation
interferometry, to better understand potential mode of action.
Analysis revealed that ApoEdpL-W and PHMB induced the highest level
of bilayer disruption, of all the antimicrobials tested. These data
suggest that apoEdpL-W demonstrates antibacterial activity;
biocompatibility and long-term efficacy on a level that compares
favourably to that of currently used biocides. The peptide
demonstrates good antimicrobial efficacy when incorporated into a
range of biomaterial polymers and shows the potential to be
developed as an…
Advisors/Committee Members: MCBAIN, ANDREW AJ, Dobson, Curtis, Mcbain, Andrew.
Subjects/Keywords: Biocide; Antimicrobial peptide; Medical device
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APA (6th Edition):
Forbes, S. (2013). Assessment of Apolipoprotein E Derived Peptides as Novel
Antimicrobials for the Coating of Biomedical Devices. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:185610
Chicago Manual of Style (16th Edition):
Forbes, Sarah. “Assessment of Apolipoprotein E Derived Peptides as Novel
Antimicrobials for the Coating of Biomedical Devices.” 2013. Doctoral Dissertation, University of Manchester. Accessed January 17, 2021.
http://www.manchester.ac.uk/escholar/uk-ac-man-scw:185610.
MLA Handbook (7th Edition):
Forbes, Sarah. “Assessment of Apolipoprotein E Derived Peptides as Novel
Antimicrobials for the Coating of Biomedical Devices.” 2013. Web. 17 Jan 2021.
Vancouver:
Forbes S. Assessment of Apolipoprotein E Derived Peptides as Novel
Antimicrobials for the Coating of Biomedical Devices. [Internet] [Doctoral dissertation]. University of Manchester; 2013. [cited 2021 Jan 17].
Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:185610.
Council of Science Editors:
Forbes S. Assessment of Apolipoprotein E Derived Peptides as Novel
Antimicrobials for the Coating of Biomedical Devices. [Doctoral Dissertation]. University of Manchester; 2013. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:185610
Tampere University
2.
Siipo, Helena.
Heuristic Evaluation of a Medical Device Prototype
.
Degree: 2019, Tampere University
URL: https://trepo.tuni.fi/handle/10024/118428
► Usability principles are often secondary to clinical effectiveness when assessing medical devices. However, the majority of medical device incidents are linked to user error. Greater…
(more)
▼ Usability principles are often secondary to clinical effectiveness when assessing medical devices. However, the majority of medical device incidents are linked to user error. Greater attention to usability evaluation during the development of a medical device can prevent patient-endangering errors. In this study, the usability of a medical device prototype is assessed through heuristic evaluation. The aim was to carry out an evaluation and to assess heuristic evaluation as a method to improve medical device usability.
The evaluated prototype is a mobile eye blink pacemaker aimed at patients with unilateral facial palsy. Facial palsy impairs the muscles responsible for producing the eye blink. Lack of blinking can result in complications such as dry eye disease and corneal ulceration. The purpose of the studied prototype is to evoke the eye blink with electrical stimulation. The device could be a simple and cost-effective alternative for more invasive methods.
Heuristics targeted particularly for medical devices are yet to be developed. Heuristic applied in this study are a combination of heuristics formerly used in other studies analyzing medical devices. The majority of usability problems detected concerned the user’s control and physical effort. The most severe problems were related to error situations. Most of the heuristic violations were rated as minor problems; no catastrophic problems were found. The most problematic part of the prototype was the adjustment of the stimulation level.
The heuristic evaluation is a quick and resource-efficient method to identify usability problems and their severities in medical devices. However, more research is needed to create a standard set of heuristics aimed especially at medical devices.
Subjects/Keywords: heuristics;
medical device;
facial palsy
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APA (6th Edition):
Siipo, H. (2019). Heuristic Evaluation of a Medical Device Prototype
. (Masters Thesis). Tampere University. Retrieved from https://trepo.tuni.fi/handle/10024/118428
Chicago Manual of Style (16th Edition):
Siipo, Helena. “Heuristic Evaluation of a Medical Device Prototype
.” 2019. Masters Thesis, Tampere University. Accessed January 17, 2021.
https://trepo.tuni.fi/handle/10024/118428.
MLA Handbook (7th Edition):
Siipo, Helena. “Heuristic Evaluation of a Medical Device Prototype
.” 2019. Web. 17 Jan 2021.
Vancouver:
Siipo H. Heuristic Evaluation of a Medical Device Prototype
. [Internet] [Masters thesis]. Tampere University; 2019. [cited 2021 Jan 17].
Available from: https://trepo.tuni.fi/handle/10024/118428.
Council of Science Editors:
Siipo H. Heuristic Evaluation of a Medical Device Prototype
. [Masters Thesis]. Tampere University; 2019. Available from: https://trepo.tuni.fi/handle/10024/118428
Indian Institute of Science
3.
Arunagiri, Srigowtham.
Assessment of University Technology Transfer Efficiency in the Context of Medical Device Technologies.
Degree: PhD, Faculty of Engineering, 2018, Indian Institute of Science
URL: http://etd.iisc.ac.in/handle/2005/3850
► Data to understand the inventiveness and technology transfer process for medical devices in India is lacking and majority of medical devices are imported. The presence…
(more)
▼ Data to understand the inventiveness and technology transfer process for
medical devices in India is lacking and majority of
medical devices are imported. The presence of a
medical school in a university system is expected to enhance healthcare inventiveness. Universities with
medical schools have 2.5 times more R&D expenditure and productivity than universities without
medical schools. Therefore, the presence or absence of
medical schools in universities serves as interesting samples for technology transfer analysis. This thesis focuses on
medical device inventiveness and technology transfer office efficiencies of American universities. Three sample sets are used. The first is data from 1242 US universities, of which 734 had
medical schools, and their Technology Transfer Office (TTO) productivity from years 1999-2008. The second consisted of 5693
medical device patents filed at USPTO by universities worldwide during years 1999-2008, including US universities. The third consisted of 32 cochlear implant university based patents from 7 primary patent classes in USPTO.
Universities involved in
medical device research (MDU) and universities not involved in
medical device research (NMDU) are compared in our study to understand differences in their technology transfer activities. Initially, Social network analysis is used to understand the interrelatedness of technologies in university based research using patent classes. Degree, betweenness and closeness centrality of 32 cochlear implant patents (out of 345 overall filed patents in USPTO including corporate filings), showed the importance of universities’ R&D contribution to the overall evolution of cochlear implant technology. Dynamics in terms of emergence and disappearance of technologies (represented by US patent classes in years 1977 to 2012), are identified.
Our study highlights that universities' research focus within
medical device research is confined to few technology classes like surgery, drugs and body treating compositions for therapeutic purposes and image analysis. In these technology areas, universities share of patent holding is found to be more compared to other
medical device technologies. Multivariate OLS and binary logistic regressions are used to understand university characteristics that influences amount of patenting by universities. Our study attempts to delineate and highlight university characteristics that may influence amount of patenting in general, i.e., across all technologies and specifically those university characteristics that may influence more patenting in
medical device technologies. Our study establishes that university characteristic variables like age, public/private ownership and research productivity influences amount of patenting by universities in general, across all technologies. However, additional university characteristics like presence of
medical school and expenditure on legal fees are found influencing amount of patenting in
medical device technologies by universities. Data Envelopment Analysis (DEA) is used in our…
Advisors/Committee Members: Ramachandran, Parthasarathy (advisor).
Subjects/Keywords: University Technology Transfer; Technology Transfer, Medical Device; Medical Device Research; Medical Device Technology Patents; Universities’ Patents; Medical Device Patents (MDU); Management
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APA (6th Edition):
Arunagiri, S. (2018). Assessment of University Technology Transfer Efficiency in the Context of Medical Device Technologies. (Doctoral Dissertation). Indian Institute of Science. Retrieved from http://etd.iisc.ac.in/handle/2005/3850
Chicago Manual of Style (16th Edition):
Arunagiri, Srigowtham. “Assessment of University Technology Transfer Efficiency in the Context of Medical Device Technologies.” 2018. Doctoral Dissertation, Indian Institute of Science. Accessed January 17, 2021.
http://etd.iisc.ac.in/handle/2005/3850.
MLA Handbook (7th Edition):
Arunagiri, Srigowtham. “Assessment of University Technology Transfer Efficiency in the Context of Medical Device Technologies.” 2018. Web. 17 Jan 2021.
Vancouver:
Arunagiri S. Assessment of University Technology Transfer Efficiency in the Context of Medical Device Technologies. [Internet] [Doctoral dissertation]. Indian Institute of Science; 2018. [cited 2021 Jan 17].
Available from: http://etd.iisc.ac.in/handle/2005/3850.
Council of Science Editors:
Arunagiri S. Assessment of University Technology Transfer Efficiency in the Context of Medical Device Technologies. [Doctoral Dissertation]. Indian Institute of Science; 2018. Available from: http://etd.iisc.ac.in/handle/2005/3850
Victoria University of Wellington
4.
Houlihan, Christina.
The development of an intellectual property strategy for a biotechnology company.
Degree: 2015, Victoria University of Wellington
URL: http://hdl.handle.net/10063/4890
► The 2014 Masters of Advanced Technology Enterprise (MATE) programme is a multi-disciplinary course with the goal of creating teams that explore the challenges of creating…
(more)
▼ The 2014 Masters of Advanced Technology Enterprise (MATE) programme is a multi-disciplinary course with the goal of creating teams that explore the challenges of creating successful technology enterprises. NacreTech is the result of one of the enterprises which has been developed within this course. It has found a market application for a nacre-like material as a biodegradable osteoconductive load bearing materials for orthopaedic implants and developed a target product profile to help guide further material development to out-compete existing materials on the market. In addition a proof of concept testing plan, intellectual property strategy and regulatory analysis has been conducted.
This thesis is based on the author’s experience working within NacreTech while applying current knowledge and thinking surrounding protecting intellectual property for biotechnology. In particular, the author has investigated the intellectual property aspects, such as the requirements of the complete specification, filing dates and locations, and existing strategy models, required for commercialisation of the NacreTech biomaterial and examines the factors which influenced the development of the intellectual strategy.
Advisors/Committee Members: Ackerly, David.
Subjects/Keywords: Patent; Biotechnology; Strategy; Medical Device
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APA (6th Edition):
Houlihan, C. (2015). The development of an intellectual property strategy for a biotechnology company. (Masters Thesis). Victoria University of Wellington. Retrieved from http://hdl.handle.net/10063/4890
Chicago Manual of Style (16th Edition):
Houlihan, Christina. “The development of an intellectual property strategy for a biotechnology company.” 2015. Masters Thesis, Victoria University of Wellington. Accessed January 17, 2021.
http://hdl.handle.net/10063/4890.
MLA Handbook (7th Edition):
Houlihan, Christina. “The development of an intellectual property strategy for a biotechnology company.” 2015. Web. 17 Jan 2021.
Vancouver:
Houlihan C. The development of an intellectual property strategy for a biotechnology company. [Internet] [Masters thesis]. Victoria University of Wellington; 2015. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/10063/4890.
Council of Science Editors:
Houlihan C. The development of an intellectual property strategy for a biotechnology company. [Masters Thesis]. Victoria University of Wellington; 2015. Available from: http://hdl.handle.net/10063/4890
Indian Institute of Science
5.
Rekha, G Naga.
An Exploratory Study of Indian Medical Device Clinical Trials : Landscaping and Assessment of Challenges.
Degree: PhD, Faculty of Engineering, 2018, Indian Institute of Science
URL: http://etd.iisc.ac.in/handle/2005/3812
► The present day world has been experiencing rapid technological advancement on the one hand and increasing number of diseases afflicting the human beings on the…
(more)
▼ The present day world has been experiencing rapid technological advancement on the one hand and increasing number of diseases afflicting the human beings on the other. To deal with the later,
medical devices are innovated and introduced in to the market (making use of the technological advancements), on a continuous basis across the world. However, taking an innovated
medical device to the market poses innumerable challenges and therefore, these have to be clinically trialled before its launch to ensure safety and efficacy. Of late, India has emerged as one of the preferred destinations to carry out clinical studies due to numerous advantages, primarily its diverse human gene pool and cost-competitiveness. However, there is very little understanding on the landscape of
medical devices clinically trialled in India. It is to throw light on this critical issue with respect to the selection of participants in the clinical trial process, selection of locations and determination of trial duration that the present study has been carried out. In addition, the role of patents associated with the introduction of new
medical devices in relation to the key challenges is examined. Furthermore, we studied the characteristics of clinical trials by industry and non-industry sponsors and between cardiovascular and other disease related trials. The present study has been carried out based on secondary data covering 108
medical device clinical trial registrations accessed from Clinical Trial Registry of India (CTRI) database pertaining to the period 2008-2014. At the outset, the pattern of trials related to the most prominent diseases such as cardiology and cardiovascular diseases and those which are invasive and non-invasive are examined. Our findings indicate that almost 50% of the trials are related to diseases of cardiology, cardiovascular diseases and those which are invasive in nature. For studying the patenting aspect, we proposed a conceptual grouping of sponsors as Incumbent, Potential Entrant and Supporter, based on their patent holdings in the domestic market and in PCT (Patent Cooperation Treaty) filings. Patents owned by Primary Sponsor (PS) showed significant variations in their clinical trial characteristics particularly the invasiveness of
device, disease type, locations and participants. Three quantitative models are developed to identify the factors that influence the selection of number of participants, locations and time taken to execute
medical device clinical trials using multivariate statistical techniques. The results of the three conceptual models on number of participants, locations and trial duration showed invasiveness of
device and disease type playing significant roles in all the three models. The number of PCTs owned by PS was found to be influential in selecting the number of locations and participants but not the patents owned in IPO (Indian Patent Office). We also observed significant differences between industry and non-industry sponsors in terms of their clinical trial characteristics. The findings…
Advisors/Committee Members: Bala Subrahmanya, M H (advisor).
Subjects/Keywords: Indian Health Care Industry; Medical Device Patenting; Medical Device Clinical Trail -India; Indian Medical Devices Industry; Medical Device Clinical Trials; Medical Device Clinical Trial Landscape; Management
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APA ·
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APA (6th Edition):
Rekha, G. N. (2018). An Exploratory Study of Indian Medical Device Clinical Trials : Landscaping and Assessment of Challenges. (Doctoral Dissertation). Indian Institute of Science. Retrieved from http://etd.iisc.ac.in/handle/2005/3812
Chicago Manual of Style (16th Edition):
Rekha, G Naga. “An Exploratory Study of Indian Medical Device Clinical Trials : Landscaping and Assessment of Challenges.” 2018. Doctoral Dissertation, Indian Institute of Science. Accessed January 17, 2021.
http://etd.iisc.ac.in/handle/2005/3812.
MLA Handbook (7th Edition):
Rekha, G Naga. “An Exploratory Study of Indian Medical Device Clinical Trials : Landscaping and Assessment of Challenges.” 2018. Web. 17 Jan 2021.
Vancouver:
Rekha GN. An Exploratory Study of Indian Medical Device Clinical Trials : Landscaping and Assessment of Challenges. [Internet] [Doctoral dissertation]. Indian Institute of Science; 2018. [cited 2021 Jan 17].
Available from: http://etd.iisc.ac.in/handle/2005/3812.
Council of Science Editors:
Rekha GN. An Exploratory Study of Indian Medical Device Clinical Trials : Landscaping and Assessment of Challenges. [Doctoral Dissertation]. Indian Institute of Science; 2018. Available from: http://etd.iisc.ac.in/handle/2005/3812
NSYSU
6.
Liu, Yin-Tse.
Study of the Information System Application in Consignment Inventory Management: A Case of the Logistic Service Provider.
Degree: Master, EMBA, 2014, NSYSU
URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0631114-091107
► In 1995, the National Health Insurance (NHI) governed by the Ministry of Health and Welfare in Taiwan was instituted nationwide. Since the time NHI was…
(more)
▼ In 1995, the National Health Insurance (NHI) governed by the Ministry of Health and Welfare in Taiwan was instituted nationwide. Since the time NHI was conceived, the budget has been running a deficit, frequently relying on government assistance with its financial problems. To solve the problems, the Ministry of Health and Welfare begin to cut costs, in ways which it changed its current reimbursement structure of current fee-for-service basis reimbursement to same pre-determined amount in the same diagnosis related groups reimbursement. This switch was known as Taiwan DRG.
The Taiwan DRG system has been controversial. Due to its nature of limiting the reimbursements, the hospitals will now try to limit costs to a minimum, therefore limiting the patients for proper care. Since
medical devices are responsible for 30% to 40% of hospital costs per DRG reimbursement, hospitals have now the incentive to specifically lower costs in
medical devices. One way to lower costs in this area is to use the consignment method in managing
medical device inventory. This means
medical device suppliers now face a new set of problems with consignment inventory management: discrepancies in inventory, product availability, and overall efficiency in logistics. Suppliers still lack the experience and knowledge to properly execute consignment management with hospitals under the Taiwan DRG system.
DKSH Healthcare is the leading partner for hospitals seeking to stabilize and grow. DKSH offer services ranging from market expansion services, and marketing and sales to physical distribution. Since 2008, our team at DKSH has accumulated many years of consignment management experience, leveraging DKSHâs high tech approach in using the latest tech solutions to solve problems for its partners.
This thesis will observe and analyze DKSH Healthcareâs methods and solutions for consignment management problems. The research and efforts spent with hospitals and suppliers from DHSK are expected to benefit everyone with a more efficient and effective process in consignment management for
medical deceives. DKSH will continue to discover new solutions and efficiencies for consignment inventory management as it partners with more hospitals and suppliers in the future.
Advisors/Committee Members: Pei-How Huang (committee member), Tsai, Hsien-tang (chair), Cher-Min Fong (chair).
Subjects/Keywords: Barcode; RFID; Inventory; Consignment; Medical Device
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APA ·
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APA (6th Edition):
Liu, Y. (2014). Study of the Information System Application in Consignment Inventory Management: A Case of the Logistic Service Provider. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0631114-091107
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Liu, Yin-Tse. “Study of the Information System Application in Consignment Inventory Management: A Case of the Logistic Service Provider.” 2014. Thesis, NSYSU. Accessed January 17, 2021.
http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0631114-091107.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Liu, Yin-Tse. “Study of the Information System Application in Consignment Inventory Management: A Case of the Logistic Service Provider.” 2014. Web. 17 Jan 2021.
Vancouver:
Liu Y. Study of the Information System Application in Consignment Inventory Management: A Case of the Logistic Service Provider. [Internet] [Thesis]. NSYSU; 2014. [cited 2021 Jan 17].
Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0631114-091107.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Liu Y. Study of the Information System Application in Consignment Inventory Management: A Case of the Logistic Service Provider. [Thesis]. NSYSU; 2014. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0631114-091107
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
NSYSU
7.
Yang, Ya-Wen.
Designs of Novel Antennas and Artificial Electromagnetic Cover Layers for Medical Implant Communication Systems.
Degree: Master, Electrical Engineering, 2012, NSYSU
URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0716112-161948
► In this thesis, we design novel implantable antennas for medical implant communication systems and it could operate with the metamaterial which is the artificial electromagnetic…
(more)
▼ In this thesis, we design novel implantable antennas for
medical implant communication systems and it could operate with the metamaterial which is the artificial electromagnetic (EM) cover layer. The metamaterial based matching layer placed on the surface of the body can improve the performance of the implantable antenna.
First, we propose two layers and three layers antenna design. The three layers antenna features high tolerance, high gain, low-profile and miniaturization. The antenna achieves gain −21.7 dBi and efficiency 0.2%. Compared with other literatures of implanted antenna design, the proposed three layers antenna reveals the best gain with similar dimensions. Furthermore, its frequency response is insensitive to the change of the implanted environment.
The conception of impedance matching is applied to further improve the gain of the proposed antenna. The matching layers are realized by utilizing the metamaterial and it is placed between the body and the air. In this case, the gain of the threeâlayer antenna can be enhanced by 1.23â5.2 dB. Furthermore, we propose a size reduction technique to reduce the thickness of the matching layer. The miniature matching layers can increase the gain of the threeâlayer antenna by 1.64 dB and 2.63 dB with the dimension of 40Ã40Ã4mm³ and 60Ã60Ã4mm³ respectively.
Finally, we propose a coâdesign method of the antenna and metamaterial. The antenna will resonate after placing metamaterial on the surface of the body. So that we can control the antenna whether to transmit power or not by the circuit design in the biomedical
device to detect the return loss of the antenna.
Advisors/Committee Members: Chih-Wen Kuo (chair), Ken-Huang Lin (committee member), Lih-Tyng Hwang (chair), Hsin-Lung Su (chair), Sung-Lin Chen (chair).
Subjects/Keywords: Implantable antenna; Implantable medical device (IMD); Metamaterial
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APA ·
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Manager
APA (6th Edition):
Yang, Y. (2012). Designs of Novel Antennas and Artificial Electromagnetic Cover Layers for Medical Implant Communication Systems. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0716112-161948
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Yang, Ya-Wen. “Designs of Novel Antennas and Artificial Electromagnetic Cover Layers for Medical Implant Communication Systems.” 2012. Thesis, NSYSU. Accessed January 17, 2021.
http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0716112-161948.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Yang, Ya-Wen. “Designs of Novel Antennas and Artificial Electromagnetic Cover Layers for Medical Implant Communication Systems.” 2012. Web. 17 Jan 2021.
Vancouver:
Yang Y. Designs of Novel Antennas and Artificial Electromagnetic Cover Layers for Medical Implant Communication Systems. [Internet] [Thesis]. NSYSU; 2012. [cited 2021 Jan 17].
Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0716112-161948.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Yang Y. Designs of Novel Antennas and Artificial Electromagnetic Cover Layers for Medical Implant Communication Systems. [Thesis]. NSYSU; 2012. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0716112-161948
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
NSYSU
8.
Wang, Kuan-Ju.
The Study on Integration Strategy of Medical Device Industry in Taiwan â The Case of the Joint Venture Project between Excelsior and Sinopharm.
Degree: Master, EMBA, 2012, NSYSU
URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0730112-233051
► Up to date, the biggest challenge of Taiwanâs medical device industry is that the major market was occupied by international companies which directly hold the…
(more)
▼ Up to date, the biggest challenge of Taiwanâs
medical device industry is that the major market was occupied by international companies which directly hold the research and development, manufacture and selling. In addition, the
medical devices have the properties in producing few products with diverse forms, research and development with complicating technology and high threshold in the application of product license. As the domestic market in Taiwan is quite small, small and medium-sized enterprises are the mainscales of Enterprises' Operating Capacity here. The chosen of joint venture of two enterprises through strategic cooperation may be one solution to survive in such ecology and play their good in order to create the core value supporting the goal of sustainability for business management. According to the policy considerations, the biotechnology and
medical treatment industry are as the important issue in ECFA agreement between Taiwan and mainland China in 2010. All together, there are hundreds and thousands of opportunities for merger, acquisitions and strategic alliance within this industyin the foreseeable future.
This study was based on the study case of the 32-years-old Excelsior. It began with dialysis market-oriented industry and then branched out into all the
medical equipment industry. Through strategic co-operation, it expanded to become a
medical integration platform providing services regarding to comprehensive roles from trade to hospital management. It accommodates the full range of downstream applications for
Medical Engineering Services, Pharmaceutical warehousing and logistics, Procurement and supply, and health care management.
Although the Excelsior has been to China ten years ago, it fails to succeed and returns back. In 2011, Excelsior makes the joining venture cooperates with the biggest pharmaceutic distributor in China, Sinopharm focuses on four major medicalterritory that are dialysis,
medical cosmetic, dentistry and health-check, and approaches the 5000 billion market in Health-Care-Reform offered by the 12th-Five year-plan of China.
However, this time it attempts a come back to become the most valuable of the integrated
medical and health industry in Asia.
Through study on the history and outcome of joining venture between Excelsior and Sinopharm in the field of
medical device industry, this thesis addresses factors that will affect business innovation integrated and product line expression. Through studying the case of Excelsior on its background, history of Strategic cooperationã integrated product lineãfinancial management and experience of success or failure in the past may provide the reference for the development of Taiwan
medical device industry.
Advisors/Committee Members: Jung-Ing Huang (committee member), Min-Hsin Huang (chair), Huang,Jen-Jsung (chair), Ying-Chun Li (committee member).
Subjects/Keywords: Sinopharm; Excelsior; Joint venture; medical device industry
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APA (6th Edition):
Wang, K. (2012). The Study on Integration Strategy of Medical Device Industry in Taiwan â The Case of the Joint Venture Project between Excelsior and Sinopharm. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0730112-233051
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Wang, Kuan-Ju. “The Study on Integration Strategy of Medical Device Industry in Taiwan â The Case of the Joint Venture Project between Excelsior and Sinopharm.” 2012. Thesis, NSYSU. Accessed January 17, 2021.
http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0730112-233051.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Wang, Kuan-Ju. “The Study on Integration Strategy of Medical Device Industry in Taiwan â The Case of the Joint Venture Project between Excelsior and Sinopharm.” 2012. Web. 17 Jan 2021.
Vancouver:
Wang K. The Study on Integration Strategy of Medical Device Industry in Taiwan â The Case of the Joint Venture Project between Excelsior and Sinopharm. [Internet] [Thesis]. NSYSU; 2012. [cited 2021 Jan 17].
Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0730112-233051.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Wang K. The Study on Integration Strategy of Medical Device Industry in Taiwan â The Case of the Joint Venture Project between Excelsior and Sinopharm. [Thesis]. NSYSU; 2012. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0730112-233051
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – Berkeley
9.
Kanjanapas, Kan.
Human Mechatronics Considerations of Sensing and Actuation Systems for Rehabilitation Application.
Degree: Mechanical Engineering, 2014, University of California – Berkeley
URL: http://www.escholarship.org/uc/item/8vg7w7bp
► With the predicted increase in worldwide elderly population in the future and already significant populations of disabled people, assistive technologies and rehabilitation devices are demanded…
(more)
▼ With the predicted increase in worldwide elderly population in the future and already significant populations of disabled people, assistive technologies and rehabilitation devices are demanded significantly. Utilizing a human mechatronic approach results in several advantages, including capability of measuring insightful information for patient's condition and providing proper assistive torque for abnormal movement correction. This dissertation investigates several domains, including (1) human dynamics model, (2) monitoring systems, and (3) design and control of active lower extremity exoskeleton.The dissertation begins with a study of a human dynamic model and sensing system for diagnosis and evaluation of patient's gait condition as first step of rehabilitation. A 7-DOF exoskeleton equipped with multiple position sensors and smart shoes is developed, so that this system can deliver patient's joint motion and estimated joint torque information. A human walking dynamic model is derived as it consists of multiple sub-dynamic models corresponding to each gait phase. In addition, a 3D human motion capture system is proposed as it utilizes an inertial measurement unit (IMU) sensor for 3D attitude estimation with embedded time varying complementary filter. This sensing system can deliver 3D orientations of upper extremities, and a forward kinematics animation. For the development of a rehabilitation device, an active lower extremity exoskeleton is proposed. A rotary series elastic actuator (RSEA) is utilized as a main actuator of the exoskeleton. The RSEA uses a torsion spring yielding elastic joint characteristics, which is safe for human robot interaction applications. A RSEA controller design is implemented, including a PID controller, a feedforward controller for friction compensation, and a disturbance observer for disturbance rejection. All sensing and actuation systems developed in this dissertation are verified by simulation studies and experiments.
Subjects/Keywords: Mechanical engineering; Control; Mechatronics; Medical Device; Rehabilitation
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APA (6th Edition):
Kanjanapas, K. (2014). Human Mechatronics Considerations of Sensing and Actuation Systems for Rehabilitation Application. (Thesis). University of California – Berkeley. Retrieved from http://www.escholarship.org/uc/item/8vg7w7bp
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kanjanapas, Kan. “Human Mechatronics Considerations of Sensing and Actuation Systems for Rehabilitation Application.” 2014. Thesis, University of California – Berkeley. Accessed January 17, 2021.
http://www.escholarship.org/uc/item/8vg7w7bp.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kanjanapas, Kan. “Human Mechatronics Considerations of Sensing and Actuation Systems for Rehabilitation Application.” 2014. Web. 17 Jan 2021.
Vancouver:
Kanjanapas K. Human Mechatronics Considerations of Sensing and Actuation Systems for Rehabilitation Application. [Internet] [Thesis]. University of California – Berkeley; 2014. [cited 2021 Jan 17].
Available from: http://www.escholarship.org/uc/item/8vg7w7bp.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kanjanapas K. Human Mechatronics Considerations of Sensing and Actuation Systems for Rehabilitation Application. [Thesis]. University of California – Berkeley; 2014. Available from: http://www.escholarship.org/uc/item/8vg7w7bp
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Vanderbilt University
10.
Garbin, Nicolo.
Endoscopic and magnetic actuation for miniature lifesaving devices.
Degree: PhD, Mechanical Engineering, 2019, Vanderbilt University
URL: http://hdl.handle.net/1803/10533
► The need for medical technologies that improve patient access to diagnostic techniques and treat pathological conditions in a minimally invasive approach is capitalized in this…
(more)
▼ The need for
medical technologies that improve patient access to diagnostic techniques and treat pathological conditions in a minimally invasive approach is capitalized in this dissertation with the development, characterization, and testing toward clinical use of a series of endoscopically and magnetically actuated devices.
The first half of this dissertation proposed an alternative solution to the use of conventional flexible endoscopy for the diagnosis of the upper gastrointestinal tract. The proposed disposable flexible endoscope is, compared to conventional endoscopy, more cost effective, intuitive, and hygienic. The device’s endoscopic tip is controlled via pneumatic actuation. Modeling was inspired from multi-backbone continuum robots, and two user interfaces were investigated. First, a robotic platform is used to tackle the closed-loop control problem, then a novel user interface allows direct user-to-task mapping via pure mechanical actuation. The effectiveness of the latter approach was further assessed during in-vivo and cadaveric trials, ease of use was instead determined via approved user studies that involved
medical providers with different backgrounds. The
device is currently undergoing design freeze toward human trials.
The second half of this dissertation exploits robotic control of magnetic actuation to develop therapeutic
medical devices with applications in minimally invasive surgery and subcutaneous implants. A laparoscopic retractor able to retract up to 10 times its own weight, and laparoscopic camera with an hemispherical workspace via a compact unique magnetic coupling, decrease by two the number of incisions needed for abdominal surgery. These technologies decrease trauma, pain, and risk of infection for the patients, and offer better visibility, surgical workspace access, and decrease trocar crowding for the surgeons. Then, a subcutaneously implantable pump developed for the treatment of refractory ascites removes a large quantity of fluids without the need of on-board electronics. All of these devices were tested during ex-vivo and in-vivo trials highlighting the advantages and effectiveness of using magnetic coupling for clinically relevant therapeutic tasks.
Advisors/Committee Members: Thomas J. Withrow (committee member), Robert J. Webster III (committee member), Nabil Simaan (committee member), Pietro Valdastri (Committee Chair), Keith L. Obstein (Committee Chair).
Subjects/Keywords: magnetic actuation; disposable; robotic; medical device
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APA (6th Edition):
Garbin, N. (2019). Endoscopic and magnetic actuation for miniature lifesaving devices. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/10533
Chicago Manual of Style (16th Edition):
Garbin, Nicolo. “Endoscopic and magnetic actuation for miniature lifesaving devices.” 2019. Doctoral Dissertation, Vanderbilt University. Accessed January 17, 2021.
http://hdl.handle.net/1803/10533.
MLA Handbook (7th Edition):
Garbin, Nicolo. “Endoscopic and magnetic actuation for miniature lifesaving devices.” 2019. Web. 17 Jan 2021.
Vancouver:
Garbin N. Endoscopic and magnetic actuation for miniature lifesaving devices. [Internet] [Doctoral dissertation]. Vanderbilt University; 2019. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/1803/10533.
Council of Science Editors:
Garbin N. Endoscopic and magnetic actuation for miniature lifesaving devices. [Doctoral Dissertation]. Vanderbilt University; 2019. Available from: http://hdl.handle.net/1803/10533
Queens University
11.
Esau, Greg.
Analysis and Design of Bearing Systems in Controlled Passive Energy Management (CPEM) Prosthetic Feet
.
Degree: Mechanical and Materials Engineering, 2014, Queens University
URL: http://hdl.handle.net/1974/12439
► The overall goal of this study is to advance the availability of prosthetic devices for developing and post conflict regions by establishing a framework for…
(more)
▼ The overall goal of this study is to advance the availability of prosthetic devices for developing and post conflict regions by establishing a framework for their design based on those used for Class II medical devices. The Niagara Foot Model 2 was used as an example case. This device has been refined within an international consortium of engineers, prosthetists, materials scientists and non-governmental organizations over the past decade. It is a unique Controlled Passive Energy Management (CPEM) foot that can be modified to suit the needs of a particular user. Its success has prompted interest in the development of other devices for this market.
Quality Function Deployment (QFD) and Failure Mode and Effects Analysis (FMEA) were used to assess the current design. A systematic literature review was used to generate 29 User-centred Functional Requirements, which were compared to 47 engineering variables extracted from the design archives. In addition, 33 potential failure modes and their mechanisms were assessed based on a Failure Mode and Effects Analysis.
Features controlling energy management in the CPEM System had the greatest impact on User-centred Functional Requirements. The potential for top plate fracture at the connection to the pylon had the highest risk rating. These observations prompted the analysis and design of the bearing system for controlled passive energy management in the current design. The analysis showed a bearing contact area, sliding speed and contact force that produced a PV value 25% above the recommended limit for Hytrel® 8238 which the horn portion of the CPEM System is comprised of. A modification to the contact geometry was proposed that would reduce the PV value by 63%, and would move the contact point forward 1.6mm. Based on a simplified static analysis, this would further reduce the peak moment in the top plate by 2%, therefore the risk to top plate failure would not be increased.
Subjects/Keywords: Analysis
;
Biomechanics
;
Design
;
Medical Device
;
Prosthetic foot
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APA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Esau, G. (2014). Analysis and Design of Bearing Systems in Controlled Passive Energy Management (CPEM) Prosthetic Feet
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/12439
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Esau, Greg. “Analysis and Design of Bearing Systems in Controlled Passive Energy Management (CPEM) Prosthetic Feet
.” 2014. Thesis, Queens University. Accessed January 17, 2021.
http://hdl.handle.net/1974/12439.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Esau, Greg. “Analysis and Design of Bearing Systems in Controlled Passive Energy Management (CPEM) Prosthetic Feet
.” 2014. Web. 17 Jan 2021.
Vancouver:
Esau G. Analysis and Design of Bearing Systems in Controlled Passive Energy Management (CPEM) Prosthetic Feet
. [Internet] [Thesis]. Queens University; 2014. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/1974/12439.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Esau G. Analysis and Design of Bearing Systems in Controlled Passive Energy Management (CPEM) Prosthetic Feet
. [Thesis]. Queens University; 2014. Available from: http://hdl.handle.net/1974/12439
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Toronto
12.
Lam, Albert.
Automation of a Multiplexed Microbead-based DNA Assay Platform.
Degree: 2015, University of Toronto
URL: http://hdl.handle.net/1807/69656
► Microbead-based diagnostic technology has been explored in academia for over 30 years. As the technology matured, it became clear that this was a competitive platform…
(more)
▼ Microbead-based diagnostic technology has been explored in academia for over 30 years. As the technology matured, it became clear that this was a competitive platform for multiplexed point- of-care diagnostics for a number of different applications spanning from healthcare, border defense, food safety and environmental monitoring. To realize the benefits of this technology to Canada and the rest of the world, it is imperative to develop an automation scheme to enable minimally trained users to be able to leverage this technology in a point-of-care setting where there is no access to a full lab, and often without reliable water or electricity. This thesis aims to leverage the use of microfluidics and magnetism to enable a simple way of automating the microbead platform for this purpose.
M.A.S.
Advisors/Committee Members: Chan, Warren CW, Biomedical Engineering.
Subjects/Keywords: diagnostics; medical device; microfluidics; nanotechnology; 0541
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APA (6th Edition):
Lam, A. (2015). Automation of a Multiplexed Microbead-based DNA Assay Platform. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/69656
Chicago Manual of Style (16th Edition):
Lam, Albert. “Automation of a Multiplexed Microbead-based DNA Assay Platform.” 2015. Masters Thesis, University of Toronto. Accessed January 17, 2021.
http://hdl.handle.net/1807/69656.
MLA Handbook (7th Edition):
Lam, Albert. “Automation of a Multiplexed Microbead-based DNA Assay Platform.” 2015. Web. 17 Jan 2021.
Vancouver:
Lam A. Automation of a Multiplexed Microbead-based DNA Assay Platform. [Internet] [Masters thesis]. University of Toronto; 2015. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/1807/69656.
Council of Science Editors:
Lam A. Automation of a Multiplexed Microbead-based DNA Assay Platform. [Masters Thesis]. University of Toronto; 2015. Available from: http://hdl.handle.net/1807/69656
University of Illinois – Chicago
13.
Zellander, Amelia.
Designing Novel Biomaterials for Cornea Replacement.
Degree: 2013, University of Illinois – Chicago
URL: http://hdl.handle.net/10027/10367
► Artificial corneas, also known as keratoprostheses (KPros), are an alternative cornea replacement therapy when donor cornea is either inappropriate or inaccessible to a patient. KPro…
(more)
▼ Artificial corneas, also known as keratoprostheses (KPros), are an alternative cornea replacement therapy when donor cornea is either inappropriate or inaccessible to a patient. KPro recipients often have preexisting ocular diseases, ocular tissue injury, or a history of corneal graft failure. While a number of KPro models are available on the market, each fails to completely address one or more of the following vital parameters: host integration, mass transport, tissue epithelialization, or innervation. This study presents biomaterials that can potentially improve stable host integration and long term vision restoration. KPros made with poly (2-hydroxyethyl methacrylate) (PHEMA) - poly (methyl methacrylate) (PMMA) (PHEMA-PMMA) and copolymers made with of PHEMA and PEG (polyethylene glycol) are structurally, mechanically, and biologically appropriate for corneal replacement. The center region of the KPro is optically transparent to permit vision; the outer rim of the
device is porous to permit tissue ingrowth. Following the addition of cell adhesion components (collagen type I) human corneal fibroblasts proliferated on the porous skirt structures. Mechanical tensile data indicated that the KPro structures are strong enough to resist rupture under the mechanical forces of the eye. PHEMA-PMMA based KPros are mechanically stable enough to be sutured in as full thickness corneal replacement devices. PHEMA and PEG copolymers, mechanically weaker than PHEMA-PMMA, are better suited for suture-less cornea replacement strategies. SEM and Micro CT data show that the pores in the skirts are large enough to permit cell ingrowth. In vivo, healthy tissues penetrate the voids of the porous copolymers. Since diseased ocular tissue is more reluctant to colonize synthetic biomaterials compared to natural-synthetic hybrids, the each skirt’s amenability to cell adhesion component addition is vital to the survival of the KPro in the target patient population. A cell adhesive KPro skirt with a high density of cell permeable pores and physiologically relevant mass transport could potentially facilitate the stable integration of a KPro into ocular tissue.
Advisors/Committee Members: Cho, Michael (advisor), Magin, Richard (committee member), Djalilian, Ali (committee member), Gemeinhart, Richard (committee member), McNallan, Michael (committee member).
Subjects/Keywords: cornea; keratoprosthesis; polymer; tissue engineering; medical device
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Export
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Manager
APA (6th Edition):
Zellander, A. (2013). Designing Novel Biomaterials for Cornea Replacement. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/10367
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Zellander, Amelia. “Designing Novel Biomaterials for Cornea Replacement.” 2013. Thesis, University of Illinois – Chicago. Accessed January 17, 2021.
http://hdl.handle.net/10027/10367.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Zellander, Amelia. “Designing Novel Biomaterials for Cornea Replacement.” 2013. Web. 17 Jan 2021.
Vancouver:
Zellander A. Designing Novel Biomaterials for Cornea Replacement. [Internet] [Thesis]. University of Illinois – Chicago; 2013. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/10027/10367.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Zellander A. Designing Novel Biomaterials for Cornea Replacement. [Thesis]. University of Illinois – Chicago; 2013. Available from: http://hdl.handle.net/10027/10367
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Manchester
14.
Forbes, Sarah.
Assessment of apolipoprotein E derived peptides as novel antimicrobials for the coating of biomedical devices.
Degree: PhD, 2013, University of Manchester
URL: https://www.research.manchester.ac.uk/portal/en/theses/assessment-of-apolipoprotein-e-derived-peptides-as-novel-antimicrobials-for-the-coating-of-biomedical-devices(86d1dcbb-33f8-4ea4-bec0-9f07b97c29b6).html
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.734200
► The microbial contamination of biomedical devices is a leading cause of hospital- acquired infection. A number of strategies aimed at developing device coatings that are…
(more)
▼ The microbial contamination of biomedical devices is a leading cause of hospital- acquired infection. A number of strategies aimed at developing device coatings that are refractory to microbial adhesion, colonisation and biofilm formation have been developed, but the problem remains. The incorporation of biocides into biomedical device surface coatings has shown promising results in preventing the establishment of infection. Current controversy over the possibility that extensive use of biocides could potentially lead to antimicrobial resistance has fuelled the search for new actives with good antimicrobial activity and low cytotoxicity, that maintain marked efficacy after prolonged use. This doctoral thesis aims to evaluate the antimicrobial potential of a novel peptide based on human apolipoprotein E receptor binding region (apoEdpL-W). The spectrum of antimicrobial activity and anti-biofilm efficacy of apoEdpL-W was compared to that of common biocides polyhexamethylene biguanide, triclosan, cetrimide and chlorhexidine. The potential to induce bacterial insusceptibility towards these agents after long-term sub-lethal level exposure was assessed. Initial examination against 18 test microorganisms, commonly associated with device infection, showed that apoEdpL-W displayed broad-range antimicrobial and anti-biofilm efficacy. ApoEdpL-W also maintained marked antibacterial activity after incorporation onto various biomaterial polymers, often used in device surface coatings. Alterations in bacterial susceptibility after prolonged exposure to apoEdpL-W, as well as to the other biocides, were often temporary and partially reverted once the bacteria had been grown in the absence of the antimicrobial agent. The adaption of Staphylococcus aureus to the presence of triclosan resulted in the formation of small colony variants (SVCs) with reduced triclosan susceptibility. Analysis of the physiological characteristics of the triclosan induced SCVs revealed the loss of virulence determinants and potentially reduced pathogenic capability, when compared to the parent strain. The biocompatibility index values of the test actives were determined by the parallel assessment of their antibacterial activity and in vitro cytotoxicity. ApoEdpL-W showed good antibacterial efficacy whilst remaining relatively less toxic to mammalian cells than triclosan or chlorhexidine. We studied the interactions of the test antimicrobials with a preformed phospholipid bilayer using the quartz crystal microbalance device and dual polarisation interferometry, to better understand potential mode of action. Analysis revealed that ApoEdpL-W and PHMB induced the highest level of bilayer disruption, of all the antimicrobials tested. These data suggest that apoEdpL-W demonstrates antibacterial activity; biocompatibility and long-term efficacy on a level that compares favourably to that of currently used biocides. The peptide demonstrates good antimicrobial efficacy when incorporated into a range of biomaterial polymers and shows the potential to be developed as an…
Subjects/Keywords: 610.28; Medical device; Biocide; Antimicrobial peptide
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APA (6th Edition):
Forbes, S. (2013). Assessment of apolipoprotein E derived peptides as novel antimicrobials for the coating of biomedical devices. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/assessment-of-apolipoprotein-e-derived-peptides-as-novel-antimicrobials-for-the-coating-of-biomedical-devices(86d1dcbb-33f8-4ea4-bec0-9f07b97c29b6).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.734200
Chicago Manual of Style (16th Edition):
Forbes, Sarah. “Assessment of apolipoprotein E derived peptides as novel antimicrobials for the coating of biomedical devices.” 2013. Doctoral Dissertation, University of Manchester. Accessed January 17, 2021.
https://www.research.manchester.ac.uk/portal/en/theses/assessment-of-apolipoprotein-e-derived-peptides-as-novel-antimicrobials-for-the-coating-of-biomedical-devices(86d1dcbb-33f8-4ea4-bec0-9f07b97c29b6).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.734200.
MLA Handbook (7th Edition):
Forbes, Sarah. “Assessment of apolipoprotein E derived peptides as novel antimicrobials for the coating of biomedical devices.” 2013. Web. 17 Jan 2021.
Vancouver:
Forbes S. Assessment of apolipoprotein E derived peptides as novel antimicrobials for the coating of biomedical devices. [Internet] [Doctoral dissertation]. University of Manchester; 2013. [cited 2021 Jan 17].
Available from: https://www.research.manchester.ac.uk/portal/en/theses/assessment-of-apolipoprotein-e-derived-peptides-as-novel-antimicrobials-for-the-coating-of-biomedical-devices(86d1dcbb-33f8-4ea4-bec0-9f07b97c29b6).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.734200.
Council of Science Editors:
Forbes S. Assessment of apolipoprotein E derived peptides as novel antimicrobials for the coating of biomedical devices. [Doctoral Dissertation]. University of Manchester; 2013. Available from: https://www.research.manchester.ac.uk/portal/en/theses/assessment-of-apolipoprotein-e-derived-peptides-as-novel-antimicrobials-for-the-coating-of-biomedical-devices(86d1dcbb-33f8-4ea4-bec0-9f07b97c29b6).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.734200
Victoria University of Wellington
15.
Hazelton, Madeleine.
Hiding in plain sight: Designing medical devices for adolescents with type 1 diabetes to match their preferences for conspicuity.
Degree: 2019, Victoria University of Wellington
URL: http://hdl.handle.net/10063/8490
► Adolescents with type 1 diabetes use medical devices that attract attention in public settings. While adolescents have varying experiences with this attention, current medical devices…
(more)
▼ Adolescents with type 1 diabetes use
medical devices that attract attention in public settings. While adolescents have varying experiences with this attention, current
medical devices do not allow them control over the conspicuousness of self-management. Accordingly, this research used a participatory design methodology to investigate adolescents’ self-management experiences and preferences regarding conspicuity, and to develop semantic strategies to inform the design of
medical devices.
Adolescent participants had varied experiences using their
medical devices to manage type 1 diabetes in public. Some adolescents were comfortable managing their diabetes in public and disclosing their condition to new people. However, other adolescents preferred to manage their type 1 diabetes in private and feel embarrassed disclosing their diabetes.
Four semantic strategies were used to design devices that could appeal to the different preferences of adolescents: to enhance traditional
medical devices to make them more beautiful, to personalise the
medical device for the user, to disguise the
medical device as a non-
medical item, and to conceal the
medical device from the public. Adolescents displayed different preferences towards these strategies and associated design concepts.
As adolescents have a range of experiences and preferences, but little control over the conspicuousness of their
medical devices, the study found that these
medical devices could be better designed to facilitate adolescents’ agency through catering to their nuanced and differing preferences for conspicuity.
Advisors/Committee Members: McCarthy, Gillian, Rodriguez Ramirez, Edgar.
Subjects/Keywords: Conspicuity; Medical device design; Type 1 diabetes
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Manager
APA (6th Edition):
Hazelton, M. (2019). Hiding in plain sight: Designing medical devices for adolescents with type 1 diabetes to match their preferences for conspicuity. (Masters Thesis). Victoria University of Wellington. Retrieved from http://hdl.handle.net/10063/8490
Chicago Manual of Style (16th Edition):
Hazelton, Madeleine. “Hiding in plain sight: Designing medical devices for adolescents with type 1 diabetes to match their preferences for conspicuity.” 2019. Masters Thesis, Victoria University of Wellington. Accessed January 17, 2021.
http://hdl.handle.net/10063/8490.
MLA Handbook (7th Edition):
Hazelton, Madeleine. “Hiding in plain sight: Designing medical devices for adolescents with type 1 diabetes to match their preferences for conspicuity.” 2019. Web. 17 Jan 2021.
Vancouver:
Hazelton M. Hiding in plain sight: Designing medical devices for adolescents with type 1 diabetes to match their preferences for conspicuity. [Internet] [Masters thesis]. Victoria University of Wellington; 2019. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/10063/8490.
Council of Science Editors:
Hazelton M. Hiding in plain sight: Designing medical devices for adolescents with type 1 diabetes to match their preferences for conspicuity. [Masters Thesis]. Victoria University of Wellington; 2019. Available from: http://hdl.handle.net/10063/8490
University of Waterloo
16.
Zhang, Shuo.
Classification of Sleep Staging For Narcolepsy Assistive Device.
Degree: 2008, University of Waterloo
URL: http://hdl.handle.net/10012/3565
► Narcolepsy is a chronic neurological disorder caused by the brain’s inability to regulate sleep wake cycles normally [1]. Narcoleptic patients feel overwhelmingly tired and sleepy.…
(more)
▼ Narcolepsy is a chronic neurological disorder caused by the brain’s inability to regulate sleep wake cycles normally [1]. Narcoleptic patients feel overwhelmingly tired and sleepy. They do not have the ability to carry out normal day time activities, such as work or study, hence proper treatment is essential. In order to provide an accurate diagnosis of the sleep disorder, physicians must analyze the sleep stages of the patient.
Sleep staging analysis is the process of extracting sleep information with brain signals known as electrophysiological signals. There are three major electrophysiological signals: Electroencephalograms (EEG), Electro-oculograms (EOG), and Electromyograms (EMG).
Through the three signals, physicians and technicians can classify the sleep stages. Although all three signals are important, most physicians and researchers agree that 95% of information can be extracted from EEG signal.
With the current technology, patients must go to the hospital and sleep there over night to perform the sleep stage studies. Electrodes are placed on their scalp, eyelids and skin for this examination. Often patients feel that it is very inconvenient and time consuming. Moreover, the technicians are prone to make human errors during the classification of the sleep stages. These errors are a result of fatigue that the technicians experience while doing the long process of classification of the sleep stages, and the complexity and ambiguity of the rules to determine the sleep stages.
Our research group has worked together to construct a portable device that will provide advice to the narcolepsy patient for activity planning and medication dosage. In addition, it provides fore-warning to the patients prior to an narcoleptic attack. This device will also perform real-time sleep analysis and alertness assessment through processing of electroencephalogram (EEG) signal.
The classification accuracy is extremely important to the development of this device. With high accuracy of the classifier, treatment for the patients can be determined more accurately by the physicians. As a result, the main purpose of the research presented in this thesis is to analyze different classification methodology and to optimize the parameters of each technology to obtain the optimal sleep stage classification results. The thesis will also present the description of the portable device and its components used for the development of the prototype.
Subjects/Keywords: Medical Device Design
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APA (6th Edition):
Zhang, S. (2008). Classification of Sleep Staging For Narcolepsy Assistive Device. (Thesis). University of Waterloo. Retrieved from http://hdl.handle.net/10012/3565
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Zhang, Shuo. “Classification of Sleep Staging For Narcolepsy Assistive Device.” 2008. Thesis, University of Waterloo. Accessed January 17, 2021.
http://hdl.handle.net/10012/3565.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Zhang, Shuo. “Classification of Sleep Staging For Narcolepsy Assistive Device.” 2008. Web. 17 Jan 2021.
Vancouver:
Zhang S. Classification of Sleep Staging For Narcolepsy Assistive Device. [Internet] [Thesis]. University of Waterloo; 2008. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/10012/3565.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Zhang S. Classification of Sleep Staging For Narcolepsy Assistive Device. [Thesis]. University of Waterloo; 2008. Available from: http://hdl.handle.net/10012/3565
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Sydney
17.
McDonald, Sarah.
Quantification of forces exerted through labour
.
Degree: 2018, University of Sydney
URL: http://hdl.handle.net/2123/20814
► This thesis is about applying a multidisciplinary approach in order to better understand the labour process. To do this the author, a mechatronic engineer, had…
(more)
▼ This thesis is about applying a multidisciplinary approach in order to better understand the labour process. To do this the author, a mechatronic engineer, had to understand what is medically known about labour and become familiar with the clinical process. This thesis explores literature related to pregnancy and labour, as well as the literature covering clinical assessments and the related supporting technology. This literary understanding was enhanced through experiences in the clinical environment. This work then combines literature and clinical learnings to best apply an engineering approach to the development of initial models and simulations. Normal labour progression was modelled by deriving formulas that focused on quantifying the forces required to dilate the cervix. These were tested using measurements from the literature and showed promise for use with clinical data. Describing the process used to develop monitoring technology, this thesis steps through the process of developing a technology that would allow women in labour to be monitored without impact to their comfort or interfering with the birthing process itself. In addition, methods used to collect clinical data from 81 women in labour are described. The thesis then combines the learnings discussed, to describe the developed methods for automatic contraction identification and models to better quantify the forces presented in labour to achieve cervical dilatation. This work provides value for both medical and engineering disciplines. It contributes to the understanding of normal labour progression and the forces exerted in labour. It shows how a multidiscipline approach can be used to better understand and solve long standing medical problems. Most importantly, this work will improve outcomes for mother and baby as it is developed with further research and commercial applications in mind.
Subjects/Keywords: pregnancy;
labour;
cervix;
progression;
medical device
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APA (6th Edition):
McDonald, S. (2018). Quantification of forces exerted through labour
. (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/20814
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
McDonald, Sarah. “Quantification of forces exerted through labour
.” 2018. Thesis, University of Sydney. Accessed January 17, 2021.
http://hdl.handle.net/2123/20814.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
McDonald, Sarah. “Quantification of forces exerted through labour
.” 2018. Web. 17 Jan 2021.
Vancouver:
McDonald S. Quantification of forces exerted through labour
. [Internet] [Thesis]. University of Sydney; 2018. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/2123/20814.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
McDonald S. Quantification of forces exerted through labour
. [Thesis]. University of Sydney; 2018. Available from: http://hdl.handle.net/2123/20814
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Akron
18.
Quang, Tri T.
Development of Compact Multimodal Optical Imaging and
Medical Assessment Systems.
Degree: MSin Engineering, Biomedical Engineering, 2015, University of Akron
URL: http://rave.ohiolink.edu/etdc/view?acc_num=akron1452533192
► Development of medical devices in a small size, lightweight and low cost design is attracting growing attentions in healthcare. Compact, portable and easy to use…
(more)
▼ Development of
medical devices in a small size,
lightweight and low cost design is attracting growing attentions in
healthcare. Compact, portable and easy to use systems that can
solve a specific
medical or health related problem and also offer
customization and integration abilities to perform multi-functional
features are appealing options to clinicians. In the thesis, two
proposed systems for multimodal optical imaging and
medical
assessment are presented. The first part describes a novel mobile
eye tracking based traumatic brain injury assessment system that
was developed to detect traumatic brain injuries (TBIs). Integrated
visual tracking and visuomotor tests were developed to assess TBI
quickly and conveniently. The system can be operated in mobile
devices such as tablets and cell phones and enables
videooculographic and visuomotor assessment of patients based on a
target-oriented visual tracking-touching synchronization. Two
simulation tests were utilized to test system performance in
detection of impaired eye movement. Statistically significant
differences between the pathological simulation and normal cases
were found in the concentration test (P<.0001), the horizontal
(P=.0005) and circular movement tests (P=.0013) with a statistical
power of 80.5%. 100% touch success and shorter time in performing
the visuomotor test were obtained in normal cases. The second part
describes the development of a Fluorescence Imaging Topology
Scanning (FITS) system. Clinically, conventional imaging modalities
such as positron emission tomography, x-ray computed tomography and
fluorescence molecular tomography can provide useful data to
clinicians. However, these tomographic imaging modalities are not
optimized for intraoperative settings due to the slow scan time and
the lack of real time update which is crucial for guiding surgery.
The FITS system can offer color reflectance imaging, fluorescence
imaging and surface topology scanning capabilities for
three-dimensional multimodal imaging. In this study, system
characterization, ex vivo image-guided surgeries in chicken and in
vivo multimodal imaging of sentinel lymph nodes (SLNs) in mice
using FITS and PET/CT were conducted to validate the capabilities
of the system in providing multimodal imaging for surgery. The
prototype offers a sub-millimeter lateral resolution, a
sub-millimeter depth resolution for topology and 10nM fluorescence
detection sensitivity. Fluorescence labeled targets were
successfully identified and highlighted. Lymph vessels (diameter
< 0.3mm) and the SLNs were imaged (average SBR of the lymph node
= 6.09 ± 0.6). The system is compact and portable, and thus
suitable for deployment in the operating room. These systems have
demonstrated great potential in supporting clinical decision making
and guiding
medical assessments.
Advisors/Committee Members: Liu, Yang (Advisor).
Subjects/Keywords: Biomedical Engineering; medical device; TBI; FITS
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APA (6th Edition):
Quang, T. T. (2015). Development of Compact Multimodal Optical Imaging and
Medical Assessment Systems. (Masters Thesis). University of Akron. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=akron1452533192
Chicago Manual of Style (16th Edition):
Quang, Tri T. “Development of Compact Multimodal Optical Imaging and
Medical Assessment Systems.” 2015. Masters Thesis, University of Akron. Accessed January 17, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=akron1452533192.
MLA Handbook (7th Edition):
Quang, Tri T. “Development of Compact Multimodal Optical Imaging and
Medical Assessment Systems.” 2015. Web. 17 Jan 2021.
Vancouver:
Quang TT. Development of Compact Multimodal Optical Imaging and
Medical Assessment Systems. [Internet] [Masters thesis]. University of Akron; 2015. [cited 2021 Jan 17].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=akron1452533192.
Council of Science Editors:
Quang TT. Development of Compact Multimodal Optical Imaging and
Medical Assessment Systems. [Masters Thesis]. University of Akron; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=akron1452533192
University of Illinois – Urbana-Champaign
19.
Lee, Yun Young.
Safe medical device interaction rules.
Degree: MS, 0112, 2011, University of Illinois – Urbana-Champaign
URL: http://hdl.handle.net/2142/18451
► The advent of computerized medical devices has resulted in better accuracy and increased safety for patients and clinicians, yet medical accidents are still not uncommon.…
(more)
▼ The advent of computerized
medical devices has resulted in better accuracy and increased safety for patients and clinicians, yet
medical accidents are still not uncommon. With the computerized
medical devices and their technical complexity, any given clinical environment is a composition of complex com- puter systems. This introduces new form of risks, not only with the usage of a single
device but with the interactions of multiple devices, which increase exponentially with respect to the number of devices. Even the most advanced
medical devices fail to serve their purpose if their users cannot effectively use them, or if their complexity deters the users.
This thesis presents an English-like configuration language for defining
device interactions rules, which makes it easier for non-programmers like clinicians and surgeons to configure a complex
medical system. The user- defined rules are then automatically and formally proven for its safety, by means of a state machine and the reachability of safe states within it. The automatic checker ensures that there is no error-by-omissions and conflicts between the rules.
Advisors/Committee Members: Johnson, Ralph E. (advisor).
Subjects/Keywords: Medical Informatics; Safety; MDPnP; Medical Devices; Medical Device Interaction.
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Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Lee, Y. Y. (2011). Safe medical device interaction rules. (Thesis). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/18451
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Lee, Yun Young. “Safe medical device interaction rules.” 2011. Thesis, University of Illinois – Urbana-Champaign. Accessed January 17, 2021.
http://hdl.handle.net/2142/18451.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Lee, Yun Young. “Safe medical device interaction rules.” 2011. Web. 17 Jan 2021.
Vancouver:
Lee YY. Safe medical device interaction rules. [Internet] [Thesis]. University of Illinois – Urbana-Champaign; 2011. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/2142/18451.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Lee YY. Safe medical device interaction rules. [Thesis]. University of Illinois – Urbana-Champaign; 2011. Available from: http://hdl.handle.net/2142/18451
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Delft University of Technology
20.
Krijgsman, Laurens (author).
The Design of a Compact Angular Drilling Device for Medical Application.
Degree: 2019, Delft University of Technology
URL: http://resolver.tudelft.nl/uuid:390e6263-ce15-496e-b7a3-3d8c3421f693
► The technology used in health care is one of the fastest developing fields in Precision Engineering. The main focus in this field is on the…
(more)
▼ The technology used in health care is one of the fastest developing fields in Precision Engineering. The main focus in this field is on the development of steerable, small dimensioned instruments. Using these, surgeries can be done with minimal damage to the patient, shorter hospital stay and more aesthetical healing. From the medical field the question arises why medical drilling devices are not developed into smaller, less invasive devices in the last years. The bulkiness of the medical drilling devices currently used is leading to inevitable challenges for surgeons. Sometimes the desired drilling location at the bone is impossible to reach with the devices currently used, alternative methods must be applied, leading to less proper healing, longer hospital stay and revalidation time. Therefore the goal of this research is to design a compact, angular drilling device for medical application. Experimental research is performed to model, analyse and understand the bone drilling process and a conceptual design for a compact, angular drill is developed.
Mechanical Engineering | Mechatronic System Design (MSD)
Advisors/Committee Members: Spronck, Jo (mentor), Delft University of Technology (degree granting institution).
Subjects/Keywords: Medical device design; Medical Drilling; Bone Drilling; Drilling Model; Angular Drill; Compact Drill; Drilling Device
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Manager
APA (6th Edition):
Krijgsman, L. (. (2019). The Design of a Compact Angular Drilling Device for Medical Application. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:390e6263-ce15-496e-b7a3-3d8c3421f693
Chicago Manual of Style (16th Edition):
Krijgsman, Laurens (author). “The Design of a Compact Angular Drilling Device for Medical Application.” 2019. Masters Thesis, Delft University of Technology. Accessed January 17, 2021.
http://resolver.tudelft.nl/uuid:390e6263-ce15-496e-b7a3-3d8c3421f693.
MLA Handbook (7th Edition):
Krijgsman, Laurens (author). “The Design of a Compact Angular Drilling Device for Medical Application.” 2019. Web. 17 Jan 2021.
Vancouver:
Krijgsman L(. The Design of a Compact Angular Drilling Device for Medical Application. [Internet] [Masters thesis]. Delft University of Technology; 2019. [cited 2021 Jan 17].
Available from: http://resolver.tudelft.nl/uuid:390e6263-ce15-496e-b7a3-3d8c3421f693.
Council of Science Editors:
Krijgsman L(. The Design of a Compact Angular Drilling Device for Medical Application. [Masters Thesis]. Delft University of Technology; 2019. Available from: http://resolver.tudelft.nl/uuid:390e6263-ce15-496e-b7a3-3d8c3421f693
Massey University
21.
Kioumars, Amir Hoshang.
Wireless data acquisition and monitoring for healthcare services systems : a thesis in the partial fulfillment of the requirement for the Masters of Engineering (Electronics and Computer Systems), Massey University, Palmerston North, New Zealand
.
Degree: 2011, Massey University
URL: http://hdl.handle.net/10179/3585
► The aging population brings challenges to healthcare systems. To cope with the high demand on health professionals and services, the feasible solution is to engage…
(more)
▼ The aging population brings challenges to healthcare systems. To cope with the high demand
on health professionals and services, the feasible solution is to engage modern technologies.
Wireless communication, service robots and information technology have become the active
research areas for future healthcare systems. In the field of human health, collecting and
analysing the real-time data is vital. New facilities and advanced tools give health service
providers and their patients more choices to readily access and use health information and
collect and store real-time health data. Information technology (IT) has the potential to improve
the quality, safety, and efficiency of healthcare. IT allows healthcare providers to collect, store,
retrieve and transfer information electronically. Together with modern communication
technologies and intelligent systems, patients are able to monitor their own vital health signs
from home and communicate the results to their health providers wirelessly. This will increase
the ability to address a problem before a patient requires acute care. The ability to remotely
monitor vital signs of a patient in real-time using a simple, low-cost and compact device with a
minimum training time is highly desirable in a society with an increasing aging population.
This research outlines the design and development of a cost effective and reliable wireless
sensing device for collecting real-time health vital signs such as human body temperature and
heart rate. A software system is also developed to provide two-way communications with the
remote sensor device in order to receive and store the collected data by the sensor device in a
central database. The literature review led to the use of ATmega micro-controller, ZigBee
technology for wireless communication and the development of highly adaptable, flexible and
intelligent software written in Microsoft C-Sharp (C#). A unique communication data packet is
also developed and implemented to overcome the micro-controller memory limitations,
improving the reliability of the communication and increasing the security of data as well as
saving power. The system is able to communicate with service robots and host computers via
the network of XBees.
The proposed hardware device is able to collect the human heart rate and body temperature in
real-time. It is light-weight, low-cost, power efficient and maintainable. It can be wrapped around
the wrist and carried with the person. It transmits the data when it is needed and stays on sleep
mode to save power.
The developed software system (T-HBR, stands for temperature-heart beat rate) is capable of
receiving the data from the remote device and storing the data to a central database. T-HBR
allows health professionals such as general practitioners (GPs), nurses and healthcare
providers to be able to collect the real-time data, see the patient‟s history, issue a new
prescription and send it to the patient, other GPs or nurses by e-mails or text messages. The
software can be a…
Subjects/Keywords: Wireless communication systems;
Medical telematics;
Remote sensing;
Remote sensing device design;
Wireless communication device design;
Healthcare device design;
Medical informatics
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APA ·
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Manager
APA (6th Edition):
Kioumars, A. H. (2011). Wireless data acquisition and monitoring for healthcare services systems : a thesis in the partial fulfillment of the requirement for the Masters of Engineering (Electronics and Computer Systems), Massey University, Palmerston North, New Zealand
. (Thesis). Massey University. Retrieved from http://hdl.handle.net/10179/3585
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kioumars, Amir Hoshang. “Wireless data acquisition and monitoring for healthcare services systems : a thesis in the partial fulfillment of the requirement for the Masters of Engineering (Electronics and Computer Systems), Massey University, Palmerston North, New Zealand
.” 2011. Thesis, Massey University. Accessed January 17, 2021.
http://hdl.handle.net/10179/3585.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kioumars, Amir Hoshang. “Wireless data acquisition and monitoring for healthcare services systems : a thesis in the partial fulfillment of the requirement for the Masters of Engineering (Electronics and Computer Systems), Massey University, Palmerston North, New Zealand
.” 2011. Web. 17 Jan 2021.
Vancouver:
Kioumars AH. Wireless data acquisition and monitoring for healthcare services systems : a thesis in the partial fulfillment of the requirement for the Masters of Engineering (Electronics and Computer Systems), Massey University, Palmerston North, New Zealand
. [Internet] [Thesis]. Massey University; 2011. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/10179/3585.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kioumars AH. Wireless data acquisition and monitoring for healthcare services systems : a thesis in the partial fulfillment of the requirement for the Masters of Engineering (Electronics and Computer Systems), Massey University, Palmerston North, New Zealand
. [Thesis]. Massey University; 2011. Available from: http://hdl.handle.net/10179/3585
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University College Cork
22.
O'Shea, Conor.
Medical device design within the ISO 13485 framework.
Degree: 2017, University College Cork
URL: http://hdl.handle.net/10468/3630
► The design and development of medical devices has become an increasing complex and regulated process. Little if any consideration is given to the regulatory requirements…
(more)
▼ The design and development of
medical devices has become an increasing complex and regulated process. Little if any consideration is given to the regulatory requirements when developing
medical devices in universities. This has resulted in an imposing barrier preventing academic innovation reaching clinical adoption. The scope of universities is not to become the legal manufacturer of
medical devices. However, should the development of novel devices ever aim to benefit patient care and reach a clinical setting, design controls must be implemented throughout the project life cycle to demonstrate feasibility and safety. The aim of this thesis is to develop user-centred technologies which comply with industrial design control practices whilst helping to bolster and promote innovation within academia. Four projects relating to
medical devices have been designed in response to well-defined and end-user-originated clinical needs. These devices can serve as the exemplar for the framework developed in this work with each reaching staggered phases of development within a controlled design process. Although unique, the devices have significant overlapping characteristics that lend the devices to parallel development, leveraging in-house know-how and ‘lessons learned’ into the process of innovation. This thesis focuses on the novelty and design of the aforementioned projects in a discrete structured approach and reflects on the development of each project within the context of a design control process which was developed as part of this work. It is the ultimate goal of this work to develop a flexible structured system compliant with the international requirements for product design and development which may be exported internationally. However, the full execution of this ambition was limited due physical, and financial limitations. This manuscript will describe the technical and commercial opportunity of devices and reflects on the success of developing same within a design control process developed as part of this work.
Advisors/Committee Members: Cantillon-Murphy, Padraig.
Subjects/Keywords: Medical devices; Medical device design; ISO 13485 framework
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Manager
APA (6th Edition):
O'Shea, C. (2017). Medical device design within the ISO 13485 framework. (Thesis). University College Cork. Retrieved from http://hdl.handle.net/10468/3630
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
O'Shea, Conor. “Medical device design within the ISO 13485 framework.” 2017. Thesis, University College Cork. Accessed January 17, 2021.
http://hdl.handle.net/10468/3630.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
O'Shea, Conor. “Medical device design within the ISO 13485 framework.” 2017. Web. 17 Jan 2021.
Vancouver:
O'Shea C. Medical device design within the ISO 13485 framework. [Internet] [Thesis]. University College Cork; 2017. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/10468/3630.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
O'Shea C. Medical device design within the ISO 13485 framework. [Thesis]. University College Cork; 2017. Available from: http://hdl.handle.net/10468/3630
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Harvard University
23.
Xu, Shuai.
PROMOTING BREAKTHROUGH MEDICAL INNOVATION: INSIGHTS FROM AN ANALYSIS OF RECENT TRANSFORMATIVE DRUGS, BIOLOGICS AND MEDICAL DEVICES.
Degree: Doctor of Medicine, 2014, Harvard University
URL: http://etds.lib.harvard.edu/hms/admin/view/54
;
http://nrs.harvard.edu/urn-3:HUL.InstRepos:12407612
► Given the recent concern from multiple healthcare stakeholders that the pipeline of medical innovation is slowing, this thesis provides insights on how to spur breakthrough…
(more)
▼ Given the recent concern from multiple healthcare stakeholders that the pipeline of medical innovation is slowing, this thesis provides insights on how to spur breakthrough medical innovation in present day. The findings and recommendations are derived from one of the largest collections of interview transcripts from biomedical innovators (n=143) responsible for developing critical devices, drugs and diagnostics used in medicine today. An exemplary case (coronary artery stent) was selected for an in-depth analysis, which included a detailed recounting of stent development and an exhaustive analysis of the patent literature. External factors either catalyzed (e.g., supportive institutions, strong underlying science and collaboration) or hindered (e.g., technology transfer challenges, lack of funding and onerous conflict of interest rules) the development process. Strategies aimed towards promoting transformative medical innovation should focus on institutional-level policies targeting early stages of innovation. This includes providing individuals with unique expertise with the capacity to pursue innovative work. Technology transfer processes should be simplified to enable collaboration for individuals between institutions with disparate expertise. Policymakers should continue to support basic science research, which underlies future innovations. In contrast, policies that increase reimbursement or reduce taxes for industry or extend patent terms are less likely to impact transformative innovation.
Subjects/Keywords: medical innovation; FDA; medical technology; drug development; device development
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APA (6th Edition):
Xu, S. (2014). PROMOTING BREAKTHROUGH MEDICAL INNOVATION: INSIGHTS FROM AN ANALYSIS OF RECENT TRANSFORMATIVE DRUGS, BIOLOGICS AND MEDICAL DEVICES. (Doctoral Dissertation). Harvard University. Retrieved from http://etds.lib.harvard.edu/hms/admin/view/54 ; http://nrs.harvard.edu/urn-3:HUL.InstRepos:12407612
Chicago Manual of Style (16th Edition):
Xu, Shuai. “PROMOTING BREAKTHROUGH MEDICAL INNOVATION: INSIGHTS FROM AN ANALYSIS OF RECENT TRANSFORMATIVE DRUGS, BIOLOGICS AND MEDICAL DEVICES.” 2014. Doctoral Dissertation, Harvard University. Accessed January 17, 2021.
http://etds.lib.harvard.edu/hms/admin/view/54 ; http://nrs.harvard.edu/urn-3:HUL.InstRepos:12407612.
MLA Handbook (7th Edition):
Xu, Shuai. “PROMOTING BREAKTHROUGH MEDICAL INNOVATION: INSIGHTS FROM AN ANALYSIS OF RECENT TRANSFORMATIVE DRUGS, BIOLOGICS AND MEDICAL DEVICES.” 2014. Web. 17 Jan 2021.
Vancouver:
Xu S. PROMOTING BREAKTHROUGH MEDICAL INNOVATION: INSIGHTS FROM AN ANALYSIS OF RECENT TRANSFORMATIVE DRUGS, BIOLOGICS AND MEDICAL DEVICES. [Internet] [Doctoral dissertation]. Harvard University; 2014. [cited 2021 Jan 17].
Available from: http://etds.lib.harvard.edu/hms/admin/view/54 ; http://nrs.harvard.edu/urn-3:HUL.InstRepos:12407612.
Council of Science Editors:
Xu S. PROMOTING BREAKTHROUGH MEDICAL INNOVATION: INSIGHTS FROM AN ANALYSIS OF RECENT TRANSFORMATIVE DRUGS, BIOLOGICS AND MEDICAL DEVICES. [Doctoral Dissertation]. Harvard University; 2014. Available from: http://etds.lib.harvard.edu/hms/admin/view/54 ; http://nrs.harvard.edu/urn-3:HUL.InstRepos:12407612
Loughborough University
24.
Grant, Tom.
The involvement of users in the design of home use medical devices : challenges and incentives for change.
Degree: PhD, 2014, Loughborough University
URL: http://hdl.handle.net/2134/16283
► The prevalence and use of medical devices in the home environment continues to grow in the United Kingdom (UK) and Worldwide. It is recognised that…
(more)
▼ The prevalence and use of medical devices in the home environment continues to grow in the United Kingdom (UK) and Worldwide. It is recognised that such devices offer significant benefits to both patients and the National Health Service in the UK. The design of home use medical devices however represents a considerable challenge to designers and manufacturers alike. Developing devices that are usable and understandable by inexperienced, lay or dexterity impaired users requires an understanding across a breadth of disciplines. Previous research in this field has explored these challenges in attempt to offer support for developers of home use medical devices. There have been very few studies however that have explored whether the design community actually need, want or use such guidance, before considering whether this literature is adopted correctly. Through case studies, an online survey and in depth interviews this thesis suggests that industry practitioners are sceptical of the value of design guidance towards user involvement in home use medical device design. Consequently the practitioners in this research make little or no use of the formal design methods and supportive guidance documents available to them. More typically, practitioners in the home use medical device field use their own personal experiences and knowledge from working in the industry to adapt their own approaches to design. This thesis reports that the greatest challenge to involving users in the design of home use medical devices are the internal corporate and traditionally hierarchical barriers between stakeholders within the design process. In contrast to previous research offering support for designers and developers of home use medical devices this thesis calls for a wider change in design practice to facilitate the application of usability principles. As a conclusion to this thesis, recommendations for further research to address these changes in practice are proposed to industry professionals in the medical device industry. This thesis is submitted as part of the requirement for the Degree of Doctor of Philosophy at Loughborough University.
Subjects/Keywords: 610.28; User involvement; Medical device design; Home use medical devices; Usability
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APA (6th Edition):
Grant, T. (2014). The involvement of users in the design of home use medical devices : challenges and incentives for change. (Doctoral Dissertation). Loughborough University. Retrieved from http://hdl.handle.net/2134/16283
Chicago Manual of Style (16th Edition):
Grant, Tom. “The involvement of users in the design of home use medical devices : challenges and incentives for change.” 2014. Doctoral Dissertation, Loughborough University. Accessed January 17, 2021.
http://hdl.handle.net/2134/16283.
MLA Handbook (7th Edition):
Grant, Tom. “The involvement of users in the design of home use medical devices : challenges and incentives for change.” 2014. Web. 17 Jan 2021.
Vancouver:
Grant T. The involvement of users in the design of home use medical devices : challenges and incentives for change. [Internet] [Doctoral dissertation]. Loughborough University; 2014. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/2134/16283.
Council of Science Editors:
Grant T. The involvement of users in the design of home use medical devices : challenges and incentives for change. [Doctoral Dissertation]. Loughborough University; 2014. Available from: http://hdl.handle.net/2134/16283
University of California – Irvine
25.
Sookwongse, Kurt Kittipon.
Modification of the External Flange of the Tympanostomy Tube to Prevent Water Entry.
Degree: Biomedical Engineering, 2014, University of California – Irvine
URL: http://www.escholarship.org/uc/item/0wx1m898
► The standard of care for Eustachian tube dysfunction is myringotomy and tympanostomy tube placement. Tympanostomy tube placement has become one of the most common otolaryngological…
(more)
▼ The standard of care for Eustachian tube dysfunction is myringotomy and tympanostomy tube placement. Tympanostomy tube placement has become one of the most common otolaryngological procedures performed today. Postoperative otorrhea remains the most common complication of tympanostomy tube placement. This has been attributed to water, and bacteria, entry into the middle ear via the conventional patent tympanostomy tube lumen. To ventilate the middle ear, the tympanostomy tube creates a constantly open tympanic membrane when it normally is closed. Patients are often advised to take precautions during common activities involving water exposure, such as bathing, showering, and swimming.In this present study, a modification was made to the external flange of a tympanostomy tube to prevent water entry, by attaching a biocompatible, hydrophobic, gas permeable membrane. Modified tympanostomy tubes and test systems to evaluate them were developed. Oxygen flow testing confirmed that the biocompatible membrane allowed air to pass through. A fluid-filled syringe and pressure gauge system allowed for testing various water column pressures and verifying that the modified tube was indeed able to prevent water entry. The final modified tubes were assembled, packaged, and sterilized for a future clinical trial pilot study.
Subjects/Keywords: Biomedical engineering; Engineering; medical device; pressure equalization; tympanostomy tube; ventilation tube
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APA (6th Edition):
Sookwongse, K. K. (2014). Modification of the External Flange of the Tympanostomy Tube to Prevent Water Entry. (Thesis). University of California – Irvine. Retrieved from http://www.escholarship.org/uc/item/0wx1m898
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Sookwongse, Kurt Kittipon. “Modification of the External Flange of the Tympanostomy Tube to Prevent Water Entry.” 2014. Thesis, University of California – Irvine. Accessed January 17, 2021.
http://www.escholarship.org/uc/item/0wx1m898.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Sookwongse, Kurt Kittipon. “Modification of the External Flange of the Tympanostomy Tube to Prevent Water Entry.” 2014. Web. 17 Jan 2021.
Vancouver:
Sookwongse KK. Modification of the External Flange of the Tympanostomy Tube to Prevent Water Entry. [Internet] [Thesis]. University of California – Irvine; 2014. [cited 2021 Jan 17].
Available from: http://www.escholarship.org/uc/item/0wx1m898.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Sookwongse KK. Modification of the External Flange of the Tympanostomy Tube to Prevent Water Entry. [Thesis]. University of California – Irvine; 2014. Available from: http://www.escholarship.org/uc/item/0wx1m898
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
26.
FENG, LILI.
Electrochemical Biosensing Techniques for Detection of NADH, Estradiol and Choline.
Degree: Chemical Engineering, 2016, UCLA
URL: http://www.escholarship.org/uc/item/8th0c8tv
► This thesis primarily focuses on optimizing electrode behavior for sensing NADH, estradiol and a metabolite of a common neurotransmitter, choline. NADH is a crucial coenzyme…
(more)
▼ This thesis primarily focuses on optimizing electrode behavior for sensing NADH, estradiol and a metabolite of a common neurotransmitter, choline. NADH is a crucial coenzyme involved in cellular energy metabolism and is one of the products of enzyme-catalyzed oxidation of estradiol that is used in its sensing. The sensing of estradiol is important for the prediction and prevention of ovarian hyperstimulation syndrome. Most current electrooxidation methods for detection of NADH rely on glassy carbon electrodes so as to avoid the electrode fouling observed with platinum and other noble metal electrodes. The modification of platinum electrodes with an acid-treated, carbon nanotube film was applied in this work to eliminate the electrode fouling effect and to increase the electrode sensitivity. A detection limit as low as 0.17 μM and an average sensitivity of 370 mA M−1 cm−2 were achieved. Also, a reduced potential could be used at the sensing electrode due to the electrocatalytic properties of the carbon nanotube coating, thus less interference from electroactive species in a sample was observed. These promising NADH sensing results suggested the feasibility of an electrochemical enzyme-multiplied immunoassay technique (EMIT) for estradiol detection. EMIT is a fast and convenient homogeneous immunoassay technology that can be practiced without much of the bulky and expensive instrumentation and tedious washing steps associated with the competing ELISA approach. EMIT relies on antibody-induced inhibition of an analyte-labeled reporter enzyme. Free analyte in solution competes for binding antibody thereby reducing reporter enzyme inhibition and resulting in increased signal with increased analyte concentration. The reporter enzyme, glucose-6-phosphate dehydrogenase, catalyzes the oxidation of glucose-6-phosphate and transfer of electrons to the β-nicotinamide adenine dinucleotide (NAD+) coenzyme to give NADH. The NADH produced has historically been detected spectrophotometrically, however our electrochemical NADH detection technology can also be used to follow reporter enzyme activity by constant potential amperometry. Electrochemical EMIT shows a linear logit-log range from 3 nM to 30 μM stradiol and exhibits a background signal that is about two times better than with spectrophotometric EMIT. The second major project of this thesis research was focused on sensing an important neurochemical, choline, with a microbiosensor on a microelectrode array microprobe. Choline is produced in the brain when the neurotransmitter, acetylcholine, is rapidly hydrolyzed. In fact, choline may serve as an effective surrogate for acetylcholine since it is turned over so rapidly to choline and acetate. Thus, there is great interest among the neuroscience community in a sensitive and fast choline sensor for near real time in vivo recording. The choline biosensor fabrication process first entails the electropolymerization of a permselective poly-m-phenylenediamine (PPD) film on the electrode surface to provide good selectivity against…
Subjects/Keywords: Chemical engineering; Biomedical engineering; biosensor; estradiol; medical device; NADH; neurotransmitters
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APA (6th Edition):
FENG, L. (2016). Electrochemical Biosensing Techniques for Detection of NADH, Estradiol and Choline. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/8th0c8tv
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
FENG, LILI. “Electrochemical Biosensing Techniques for Detection of NADH, Estradiol and Choline.” 2016. Thesis, UCLA. Accessed January 17, 2021.
http://www.escholarship.org/uc/item/8th0c8tv.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
FENG, LILI. “Electrochemical Biosensing Techniques for Detection of NADH, Estradiol and Choline.” 2016. Web. 17 Jan 2021.
Vancouver:
FENG L. Electrochemical Biosensing Techniques for Detection of NADH, Estradiol and Choline. [Internet] [Thesis]. UCLA; 2016. [cited 2021 Jan 17].
Available from: http://www.escholarship.org/uc/item/8th0c8tv.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
FENG L. Electrochemical Biosensing Techniques for Detection of NADH, Estradiol and Choline. [Thesis]. UCLA; 2016. Available from: http://www.escholarship.org/uc/item/8th0c8tv
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
UCLA
27.
Suwarnasarn, Arnold Tirapat.
Materials approach to novel endovascular coils with enhanced wound healing for intracranial aneurysms.
Degree: Bioengineering, 2015, UCLA
URL: http://www.escholarship.org/uc/item/46j3w5pv
► An intracranial aneurysm (ICA) is a local distension within the arterial wall of the brain. Within the United States it is estimated that 15 million…
(more)
▼ An intracranial aneurysm (ICA) is a local distension within the arterial wall of the brain. Within the United States it is estimated that 15 million people have some form of an ICA, with an additional incidence rate of 75,000 patients per year. When a patient experiences an aneurysm rupture, 15% of patients will die before reaching the hospital. However shockingly, 50% of patients that receive treatment with existing technology will die within the first 30 days. Therefore, current technology must be improved to for fast and effective treatment. The goal of this research was to utilize inherent biomaterial properties for the purposes of accelerating the ICA wound healing process. We have developed a novel endovascular device around clinical practice with high potential for commercial development. Requirements for technological development were to limit friction during deployment, validate coating quality for commercial fabrication, and achieve accelerated intracranial aneurysm wound healing above bare platinum coils (BPC). Research has shown that materials can influence the wound healing cascade. It was hypothesized that inducing a stronger inflammatory reaction will lead to accelerated wound healing mechanisms downstream. We have shown that fast degrading acid modified poly(lactic-co-glycolic) polymers (aPLGA) can further accelerate this process by early induction of the inflammatory phase. To further understand the mechanism behind accelerated ICA wound healing, we performed in vitro analysis of low molecular weight aPLGA. Cellular response to aPLGA showed increased levels of inflammatory cytokines as well as collagen deposition. In addition, in vivo tests were performed in swine and showed significant healing above BPCs and another commercially available coil type.Degradable metals were investigated for the potential to induce accelerated ICA healing in vitro. Candidate degradable metals were chosen based on biocompatibility and commercial feasibility for production. Electroplated iron on BPCs showed an increase of inflammatory cytokines in vitro as well as collagen deposition against controls. Proof of concept for commercial development was shown by atomic sputter deposition. The goal of this research was to develop novel solutions to achieve accelerated ICA wound healing through inherent biomaterial properties. This goal was achieved by elucidating candidate materials which induced enhanced inflammatory reactions, and then constructed processes for commercial fabrication.
Subjects/Keywords: Biomedical engineering; biomaterials; inflammation; intracranial aneurysm; medical device
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APA ·
Chicago ·
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Export
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APA (6th Edition):
Suwarnasarn, A. T. (2015). Materials approach to novel endovascular coils with enhanced wound healing for intracranial aneurysms. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/46j3w5pv
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Suwarnasarn, Arnold Tirapat. “Materials approach to novel endovascular coils with enhanced wound healing for intracranial aneurysms.” 2015. Thesis, UCLA. Accessed January 17, 2021.
http://www.escholarship.org/uc/item/46j3w5pv.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Suwarnasarn, Arnold Tirapat. “Materials approach to novel endovascular coils with enhanced wound healing for intracranial aneurysms.” 2015. Web. 17 Jan 2021.
Vancouver:
Suwarnasarn AT. Materials approach to novel endovascular coils with enhanced wound healing for intracranial aneurysms. [Internet] [Thesis]. UCLA; 2015. [cited 2021 Jan 17].
Available from: http://www.escholarship.org/uc/item/46j3w5pv.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Suwarnasarn AT. Materials approach to novel endovascular coils with enhanced wound healing for intracranial aneurysms. [Thesis]. UCLA; 2015. Available from: http://www.escholarship.org/uc/item/46j3w5pv
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Utah
28.
Li, Huizhong.
Vascular coupling device for end-to-end anastomosis.
Degree: PhD, Mechanical Engineering, 2015, University of Utah
URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/3932/rec/2885
► In microsurgical operating room environments, it is often necessary to cut and reattach vessels multiple times during surgery. The current method of vascularanastomosis is hand…
(more)
▼ In microsurgical operating room environments, it is often necessary to cut and reattach vessels multiple times during surgery. The current method of vascularanastomosis is hand suturing. This technique is time consuming, difficult, and requires complex instruments. To solve this problem, researchers have explored alternative ways to improve this technique. Typical examples are staples, clips, cuffing rings, adhesives,and laser welding. The potential of these techniques has been hindered due to the lack of biocompatibility, complex procedures for use, and general inefficiency. As a result, few of these devices have been commercialized.One promising alternative is a ring-pin coupling device. This device has been shown to be useful for venous anastomosis, but lacks the versatility necessary for arterial applications. One purpose of this study was to optimize a vascular coupling design that could be used for arteries and veins of various sizes. To achieve this, finite element analysis was used to simulate the vessel-device interaction during anastomosis.Parametric simulations were performed to optimize the number of pins, the wing pivot point, and the pin offset of the design. The interaction of the coupler with various blood vessel sizes was also evaluated.The optimal vascular coupling device has four rotatable wings and one translatable spike in each wing. Prototypes were manufactured using polytetrafluoroethylene (PTFE) and high-density polyethylene (HDPE). A set of installation tools was designed to facilitate the anastomosis process. Proof-of-concept testing with the vascular coupler using plastic tubes and porcine cadaver vessels showed that the coupler could be efficiently attached to blood vessels, did not leak after the anastomosis was performed,had sufficient joint strength, and had little impact on flow in the vessel. A simplified finite element model assisted in the evaluation of the tearing likelihood of humanvessels during installation of the coupler. The entire anastomosis process can be completed in three minutes when using the vascular coupler to join porcine cadavervessels.A metal-free vascular coupling system that can be used for both arteries and veins was designed, fabricated, and tested. A set of corresponding instruments weredeveloped to facilitate the anastomosis process. Evaluation of the anastomosis by Scanning Electron Microscopy (SEM) and Magnetic Resonance Imaging (MRI)demonstrated that the installation process does not cause damage to the vessel intima and the vascular coupling system is not exposed to the vessel lumen. Mechanical testing results showed that vessels reconnected with the vascular coupling system couldwithstand 12.7±2.2 N tensile force and have superior leak profiles compared to hand sutured vessels. The anastomotic process was successfully demonstrated on both arteries and veins in cadaver and live pigs.
Subjects/Keywords: Anastomosis; Blood Vessel; Finite Element Analysis; Medical Device; Microsurgery; Vascular Coupler
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APA ·
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APA (6th Edition):
Li, H. (2015). Vascular coupling device for end-to-end anastomosis. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/3932/rec/2885
Chicago Manual of Style (16th Edition):
Li, Huizhong. “Vascular coupling device for end-to-end anastomosis.” 2015. Doctoral Dissertation, University of Utah. Accessed January 17, 2021.
http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/3932/rec/2885.
MLA Handbook (7th Edition):
Li, Huizhong. “Vascular coupling device for end-to-end anastomosis.” 2015. Web. 17 Jan 2021.
Vancouver:
Li H. Vascular coupling device for end-to-end anastomosis. [Internet] [Doctoral dissertation]. University of Utah; 2015. [cited 2021 Jan 17].
Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/3932/rec/2885.
Council of Science Editors:
Li H. Vascular coupling device for end-to-end anastomosis. [Doctoral Dissertation]. University of Utah; 2015. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/3932/rec/2885
University of Manchester
29.
Chung, Chao-Chen.
Government, Governance and the Development of the
Innovation Systems: The example of the Taiwanese biotechnology and
related sectoral policies.
Degree: 2011, University of Manchester
URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:122082
► This thesis focuses on the research of RTDI policies (research, technology, development and innovation), and the main theme of this thesis is to link the…
(more)
▼ This thesis focuses on the research of RTDI
policies (research, technology, development and innovation), and
the main theme of this thesis is to link the three variables
together: RTDI policy-making process – the contents of RTDI
policies – the appropriateness of RTDI policies on configuration of
the national, the sectoral and the technological innovation
systems. We assume the policy-making process of RTDI policies would
shape the contents of the RTDI policies. Once the contents of RTDI
policies are implemented, the RTDI policies would influence,
whether appropriate or inappropriate, on configuration of the three
innovation systems. We define the configuration of the three
innovation systems as national, sectoral and technological
innovation system (NSTIS). We use the Taiwanese biotechnology and
related sectoral policies as the empirical examples. Biotechnology
in Taiwan configures with three sectors, i.e. pharmaceuticals,
agriculture and medical device. Between 2000 and 2008, the
Taiwanese government intensively promoted many policies in order to
support the development of biotechnology and related sectors. Among
the various policies, we choose the National Science and Technology
Programs and the regulation policies (in terms of Law of
Pharmaceutical Affairs and the Agro-pesticides Management Act) as
our two empirical cases and set up the in-depth discussion for the
policy-making process of the two policies.On the basis of the
empirical cases of Taiwan, we explore the influence of the RTDI
policy-making process on the contents of RTDI policies which
further shapes the development of the NSTIS.
NO
NO
Advisors/Committee Members: MCMEEKIN, ANDREW AP, Mcmeekin, Andrew, Edler, Jakob.
Subjects/Keywords: innovation system; policy; policy-making; Taiwan; biotechnology; pharmaceuticals; agriculture; medical device
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APA ·
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MLA ·
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Manager
APA (6th Edition):
Chung, C. (2011). Government, Governance and the Development of the
Innovation Systems: The example of the Taiwanese biotechnology and
related sectoral policies. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:122082
Chicago Manual of Style (16th Edition):
Chung, Chao-Chen. “Government, Governance and the Development of the
Innovation Systems: The example of the Taiwanese biotechnology and
related sectoral policies.” 2011. Doctoral Dissertation, University of Manchester. Accessed January 17, 2021.
http://www.manchester.ac.uk/escholar/uk-ac-man-scw:122082.
MLA Handbook (7th Edition):
Chung, Chao-Chen. “Government, Governance and the Development of the
Innovation Systems: The example of the Taiwanese biotechnology and
related sectoral policies.” 2011. Web. 17 Jan 2021.
Vancouver:
Chung C. Government, Governance and the Development of the
Innovation Systems: The example of the Taiwanese biotechnology and
related sectoral policies. [Internet] [Doctoral dissertation]. University of Manchester; 2011. [cited 2021 Jan 17].
Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:122082.
Council of Science Editors:
Chung C. Government, Governance and the Development of the
Innovation Systems: The example of the Taiwanese biotechnology and
related sectoral policies. [Doctoral Dissertation]. University of Manchester; 2011. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:122082
Vanderbilt University
30.
Di Natali, Christian.
Magnetic Medical Capsule Robots.
Degree: PhD, Mechanical Engineering, 2015, Vanderbilt University
URL: http://hdl.handle.net/1803/12993
► Over the last decade, researchers have started exploring the design space of Medical Capsule Robots (MCRs): devices that can operate within the human body performing…
(more)
▼ Over the last decade, researchers have started exploring the design space of
Medical
Capsule Robots (MCRs): devices that can operate within the human body performing
functionalities such as diagnosing, monitoring, and treating diseases. Clinical applications
for MCRs span from abdominal surgery to endoscopy. MCRs are severely resource constrained
devices in size and in available mechanical/electrical power.
Magnetic manipulation is becoming one of the main strategies for MCRs navigation and
remote actuation, as it allows the transmission of forces across a physical barrier without
requiring an internal source of power.
The current state of the art lacks proprioceptive systems able to control magnetic actuation
to enable MCRs to perform
medical procedures. This dissertation presents controllable
strategies for remote and local magnetic manipulation of MCRs combined with real-time
proprioceptive sensing.
The study focuses on two main applications: magnetic pose detection for navigation
of Wireless Capsule Endoscope (WCE) along the gastrointestinal (GI) tract, and Local
Magnetic Actuation (LMA) for powering Degrees of Freedoms (DOFs) of abdominal surgical
robots.
The proposed magnetic pose detection algorithms were successfully applied to remote
navigation on several WCE prototypes during in-vivo trials. Two different approaches
for magnetic pose detection compatible with magnetic actuation based on sensor fusion
are presented and evaluated. The first approach takes advantage of the magnetic field
mathematical derivation based on cylindrical symmetry, performing absolute pose detection
for 50 Hz real-time systems. The second algorithm achieves a refresh rate of 1 kHz applying
a least square interpolation to the finite element solution of the magnetic field, to obtain
Jacobians closed-form expression function of capsule poses changes. A third algorithm
estimates the force generated by magnetic coupling along the magnetization direction to
study the force required to drag WCEs along the GI tract.
The second topic covers the design and control for the LMA. This concept allows
the transmission of rotary motion by applying the magnetic spur gear concept to actuate
robotic DOFs of MCRs. The proposed dynamic model is used to design closed-loop control
strategies. Two surgical tools based on the LMA are presented: a single-DOF retractor and
a 4-DOF manipulator.
Advisors/Committee Members: Keith Obstein (committee member), Nabil Simaan (committee member), Robert Webster (committee member), Karl Zelik (committee member), Pietro Valdastri (Committee Chair).
Subjects/Keywords: control; endoscopy; surgery; magnetic localization; magnetic device; medical robotisc
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APA ·
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Manager
APA (6th Edition):
Di Natali, C. (2015). Magnetic Medical Capsule Robots. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/12993
Chicago Manual of Style (16th Edition):
Di Natali, Christian. “Magnetic Medical Capsule Robots.” 2015. Doctoral Dissertation, Vanderbilt University. Accessed January 17, 2021.
http://hdl.handle.net/1803/12993.
MLA Handbook (7th Edition):
Di Natali, Christian. “Magnetic Medical Capsule Robots.” 2015. Web. 17 Jan 2021.
Vancouver:
Di Natali C. Magnetic Medical Capsule Robots. [Internet] [Doctoral dissertation]. Vanderbilt University; 2015. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/1803/12993.
Council of Science Editors:
Di Natali C. Magnetic Medical Capsule Robots. [Doctoral Dissertation]. Vanderbilt University; 2015. Available from: http://hdl.handle.net/1803/12993
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Open Access Theses and Dissertations
