subject:(lung health)

University of Melbourne

1. Bui, Dinh Son. Risk factors for and outcomes of lung function deficits throughout the lifespan.

Degree: 2019, University of Melbourne

► Good lung function is essential for general health and longevity. The lungs are responsible for providing oxygen to meet the metabolic demands of the body… (more)

▼ Good lung function is essential for general health and longevity. The lungs are responsible for providing oxygen to meet the metabolic demands of the body and expelling waste products of cellular respiration. They also play a critical role in maintaining acid-base balance. Impaired lung function imposes significant health issues. Chronic obstructive pulmonary disease (COPD) in late adulthood is responsible for the largest burden. Across the life course, lung function passes through different phases (development, growth, plateau, and decline). Lung function is influenced by multiple risk factors that act at different periods, which together form a complex web contributing to lifetime risk. Understanding how particular risk factors influence each phase as well as the lifetime trajectory of lung function and the consequences of these impairments is critical for evidence-based strategies to promote lung health and prevent lung diseases. However, such understanding is limited. Specifically, some major gaps in this literature include: how reduced lung development and growth in early life influence the risk of COPD and its phenotypes in later life; how multiple early life factors interact and predict long-term lung function deficits and COPD; how adult life factors interact with genetic and early life factors to influence lung function decline; and what are the determinants and consequences of different lifetime lung function trajectories. In this thesis, I aim to investigate risk factors for, and outcomes of, lung function deficits throughout the life course, using data from the Tasmanian Longitudinal Health Study (TAHS). My specific objectives are (1) to investigate the association between childhood lung function and asthma-COPD phenotypes in middle age, (2) to identify childhood respiratory risk factor profiles that influence lung function and COPD development in middle age and to examine the causal pathways involving potential mediators and effect modifiers, (3) to establish trajectories of lung function from childhood to the sixth decade and to investigate the association between identified lung function trajectories and both early life determinants and subsequent COPD risk, and (4) to investigate how interactions between major adverse exposures in adulthood, early life respiratory risk factors and potential genetic factors may influence lung function decline in middle age. In chapter 4, I present my findings that lower lung function at age seven years predicted higher risk of COPD and asthma-COPD overlap syndrome (ACOS) in middle age, independent of personal smoking. In particular, I found that being in the lowest quartile of the ratio of forced expiratory volume in 1 second to forced vital capacity (FEV1/FVC) at age seven years was associated with a 5.8 fold and 9.8 fold increase in the risk of COPD and ACOS, respectively. In chapter 5, I present my results identifying six distinct profiles of childhood respiratory risk factors. These risk profiles were associated with differing risks of reduced lung…

Subjects/Keywords: lung function; lung health; risk factor; COPD; epidemiology; biostatistics; respiratory; allergy

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APA (6^th Edition):

Bui, D. S. (2019). Risk factors for and outcomes of lung function deficits throughout the lifespan. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/225032

Chicago Manual of Style (16^th Edition):

Bui, Dinh Son. “Risk factors for and outcomes of lung function deficits throughout the lifespan.” 2019. Doctoral Dissertation, University of Melbourne. Accessed March 04, 2021. http://hdl.handle.net/11343/225032.

MLA Handbook (7^th Edition):

Bui, Dinh Son. “Risk factors for and outcomes of lung function deficits throughout the lifespan.” 2019. Web. 04 Mar 2021.

Vancouver:

Bui DS. Risk factors for and outcomes of lung function deficits throughout the lifespan. [Internet] [Doctoral dissertation]. University of Melbourne; 2019. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11343/225032.

Council of Science Editors:

Bui DS. Risk factors for and outcomes of lung function deficits throughout the lifespan. [Doctoral Dissertation]. University of Melbourne; 2019. Available from: http://hdl.handle.net/11343/225032

University of South Carolina

2. Kilpatrick, Daniel John. Investigating the Relationship of COPD, Lung Cancer, and Polycyclic Aromatic Hydrocarbons From Ambient Air Pollution.

Degree: PhD, Environmental Health Sciences, 2019, University of South Carolina

URL: https://scholarcommons.sc.edu/etd/5573

► Polycylic aromatic hydrocarbons (PAHs) are a group of chemically-related compounds with a well-established body of evidence of adverse human health impacts. Additionally, there is… (more)

▼ Polycylic aromatic hydrocarbons (PAHs) are a group of chemically-related compounds with a well-established body of evidence of adverse human health impacts. Additionally, there is a growing area of research on the health outcomes following PAH exposure via air pollution, specifically with chronic obstructive pulmonary disorder (COPD) and lung cancer. The purpose of this dissertation was to investigate the strength of associations among PAHs, COPD, and lung cancer from ambient (outdoor) air pollution. The first objective was to determine if there is a potential environmental link among PAHs, COPD, and lung cancer occurrence among nonsmokers using data from the National Health and Nutrition Examination Survey (NHANES). The second objective was to test the hypothesis that a significant association exists among PAHs, COPD, and lung cancer deaths in South Carolina (SC) using the National Air Toxics Assessment (NATA) models developed by the Environmental Protection Agency (EPA). The third and final objective of this research was to utilize the models developed in the previous objective and apply it to a large metropolitan context to determine if the same or similar associations with COPD and lung cancer deaths were observed. New York City was selected as the jurisdiction for this section of the research due to its context of a probable interface with a dense population and a variety of known air pollution sources i.e. the port of NY/NJ. For the first objective, PAHs were not statistically significant (p=0.4828) in their association with COPD occurrence among non-smoking respondents after adjusting for known confounders i.e. age, secondhand smoke exposure, former smokers, BMI, etc. The results investigating the strength of association between PAHs and lung cancer among nonsmokers were unreliable due to the small sample size of lung cancer respondents (n=37) in the NHANES dataset and are not included. For the second objective, PAHs were significantly associated with COPD deaths (p=0.0094 to p The results for the third objective for New York City were mixed. For both COPD and lung cancer death models, there were statistically significant associations with PAHs at the census tract level (p In conclusion, taking into account each of the confounders included in the analysis for the COPD death model in SC specifically, there are implications for air pollution remediation across the state. Additional study is warranted investigating a morbidity model using data such as hospitalizations from acute exacerbations of COPD (as well as lung cancer or other respiratory-related illnesses, i.e. asthma) and investigating their associations with PAHs at the census tract level. A death model includes a longer period of time between dose and response which could be mitigated with a morbidity model. Next, other biomarkers for air pollutants, i.e. particulate matter Advisors/Committee Members: Geoffrey I. Scott, Dwayne E. Porter.

Subjects/Keywords: Environmental Health; COPD; lung cancer; lung; air pollution

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APA (6^th Edition):

Kilpatrick, D. J. (2019). Investigating the Relationship of COPD, Lung Cancer, and Polycyclic Aromatic Hydrocarbons From Ambient Air Pollution. (Doctoral Dissertation). University of South Carolina. Retrieved from https://scholarcommons.sc.edu/etd/5573

Chicago Manual of Style (16^th Edition):

Kilpatrick, Daniel John. “Investigating the Relationship of COPD, Lung Cancer, and Polycyclic Aromatic Hydrocarbons From Ambient Air Pollution.” 2019. Doctoral Dissertation, University of South Carolina. Accessed March 04, 2021. https://scholarcommons.sc.edu/etd/5573.

MLA Handbook (7^th Edition):

Kilpatrick, Daniel John. “Investigating the Relationship of COPD, Lung Cancer, and Polycyclic Aromatic Hydrocarbons From Ambient Air Pollution.” 2019. Web. 04 Mar 2021.

Vancouver:

Kilpatrick DJ. Investigating the Relationship of COPD, Lung Cancer, and Polycyclic Aromatic Hydrocarbons From Ambient Air Pollution. [Internet] [Doctoral dissertation]. University of South Carolina; 2019. [cited 2021 Mar 04]. Available from: https://scholarcommons.sc.edu/etd/5573.

Council of Science Editors:

Kilpatrick DJ. Investigating the Relationship of COPD, Lung Cancer, and Polycyclic Aromatic Hydrocarbons From Ambient Air Pollution. [Doctoral Dissertation]. University of South Carolina; 2019. Available from: https://scholarcommons.sc.edu/etd/5573

3. Sandhu, Ritem. Estimating the Burden of Disease of Lung Cancer at the County-Level in California.

Degree: Social Sciences, 2018, University of California – Merced

URL: http://www.escholarship.org/uc/item/4dk2r7f1

► An estimated 40,000 people in California suffered from lung cancer in 2014, including nearly 2,000 Medi-Cal recipients. Although the increased coverage by Center for Medicaid… (more)

Subjects/Keywords: Public health; Costs; Lung cancer; QALYs; ROI

1 more image…

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APA (6^th Edition):

Sandhu, R. (2018). Estimating the Burden of Disease of Lung Cancer at the County-Level in California. (Thesis). University of California – Merced. Retrieved from http://www.escholarship.org/uc/item/4dk2r7f1

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sandhu, Ritem. “Estimating the Burden of Disease of Lung Cancer at the County-Level in California.” 2018. Thesis, University of California – Merced. Accessed March 04, 2021. http://www.escholarship.org/uc/item/4dk2r7f1.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sandhu, Ritem. “Estimating the Burden of Disease of Lung Cancer at the County-Level in California.” 2018. Web. 04 Mar 2021.

Vancouver:

Sandhu R. Estimating the Burden of Disease of Lung Cancer at the County-Level in California. [Internet] [Thesis]. University of California – Merced; 2018. [cited 2021 Mar 04]. Available from: http://www.escholarship.org/uc/item/4dk2r7f1.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sandhu R. Estimating the Burden of Disease of Lung Cancer at the County-Level in California. [Thesis]. University of California – Merced; 2018. Available from: http://www.escholarship.org/uc/item/4dk2r7f1

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Michigan

4. Lau, Yan Kwan. Translational Epidemiology: An Application of Lung Cancer Prevention Strategies in USA and Mexico.

Degree: PhD, Epidemiological Science, 2019, University of Michigan

URL: http://hdl.handle.net/2027.42/151443

► Lung cancer is the number one cause of cancer-related deaths in the US and worldwide. This is an aggressive disease with few treatment options if… (more)

▼ Lung cancer is the number one cause of cancer-related deaths in the US and worldwide. This is an aggressive disease with few treatment options if discovered at a late stage, as it often is. Therefore, reducing the burden of lung cancer should focus on primary and secondary prevention strategies: tobacco control and lung cancer screening. However, to implement effective interventions, we need to be familiar with a variety of methods and engage with different perspectives and stakeholders. Through the lens of translational epidemiology, this dissertation presents three analyses applied to different contexts to address the lung cancer burden. First, we describe a study using mixed methods to design and evaluate a web-tool for lung cancer screening informed decision-making in Metro Detroit. Through participatory design workshops, we identify design features that may be salient for other developers of web-based decision aids for both lung cancer screening and other health interventions. Afterwards, we conduct a quasi-experimental study with before-after surveys to test a modified version of a web-based decision aid, shouldiscreen.com, in an African American community in Detroit. We find that using the decision aid moderately improves lung cancer screening knowledge and concordance of individual preference for screening with clinical guidelines. Use of the tool also decreases decisional conflict with regards to lung cancer screening. We contact these survey participants after six months over the phone and ask if they had taken steps to see a clinician and enquire about lung cancer screening. A subset of the survey takers also participate in a focus group to give more in-depth feedback about their experience using shouldiscreen.com, which we use to triangulate our findings in the participatory design workshops. This aim demonstrates various design and implementation challenges for web-based lung cancer screening decision aids, particularly when considering the needs of low-resource communities with limited access to the internet and individuals with low levels of literacy. Second, we present an age-period-cohort analysis of smoking patterns in Mexico using nationally representative cross-sectional data from 1987 to 2016. Specifically,we estimate trends in smoking prevalence, initiation and cessation by birth cohort and sex. The results show that while smoking prevalence and initiation have decreased,progress has slowed and even reversed for younger birth cohorts. Moreover, the analysis reveals that there has been a shift in smoking patterns from daily to non-daily smoking in recent years. This shift may have implications in how tobacco control policies would be implemented in future. Third, we develop a computational model of smoking prevalence for Mexico, which accounts for the current patterns of use uncovered in Aim 2, and explicitly tracks daily and non-daily smokers. The model suggests that if smoking initiation and cessation remain at current levels, there will be around 18 million male and 4 million female smokers… Advisors/Committee Members: Meza, Rafael (committee member), Rozek, Laura Marie (committee member), Arenberg, Doug (committee member), Eisenberg, Marisa Cristina (committee member), Jeon, Jihyoun (committee member).

Subjects/Keywords: smoking; lung cancer screening; Public Health; Health Sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lau, Y. K. (2019). Translational Epidemiology: An Application of Lung Cancer Prevention Strategies in USA and Mexico. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/151443

Chicago Manual of Style (16^th Edition):

Lau, Yan Kwan. “Translational Epidemiology: An Application of Lung Cancer Prevention Strategies in USA and Mexico.” 2019. Doctoral Dissertation, University of Michigan. Accessed March 04, 2021. http://hdl.handle.net/2027.42/151443.

MLA Handbook (7^th Edition):

Lau, Yan Kwan. “Translational Epidemiology: An Application of Lung Cancer Prevention Strategies in USA and Mexico.” 2019. Web. 04 Mar 2021.

Vancouver:

Lau YK. Translational Epidemiology: An Application of Lung Cancer Prevention Strategies in USA and Mexico. [Internet] [Doctoral dissertation]. University of Michigan; 2019. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/2027.42/151443.

Council of Science Editors:

Lau YK. Translational Epidemiology: An Application of Lung Cancer Prevention Strategies in USA and Mexico. [Doctoral Dissertation]. University of Michigan; 2019. Available from: http://hdl.handle.net/2027.42/151443

University of Michigan

5. Chang, Joanne. Characterizing the Temporal Aspects of Tobacco Use and Its Related Diseases.

Degree: PhD, Epidemiological Science, 2017, University of Michigan

URL: http://hdl.handle.net/2027.42/137154

► Tobacco use is a causative agent of various diseases including cancer, cardiovascular diseases (CVD), chronic obstructive pulmonary disease (COPD) and other non-communicable diseases (NCDs). However,… (more)

▼ Tobacco use is a causative agent of various diseases including cancer, cardiovascular diseases (CVD), chronic obstructive pulmonary disease (COPD) and other non-communicable diseases (NCDs). However, the way in which complex time-varying tobacco use patterns shape disease risk is less well understood. In the United States (US), smoking prevalence has declined, but the use of alternative tobacco products (chewing tobacco, snus, snuff, e-cigarettes) has remained constant or is increasing. These changes further complicate the relationship between tobacco exposure and health outcomes at the population and individual levels. Globally, there is a drastic shift in global tobacco use from high-income countries to low- and middle- income countries, where the burden of tobacco-related NCDs is predicted to rise 70% by 2030. This dissertation seeks to address the temporal aspects of tobacco use and its related health conditions to further assess the health and financial costs of the tobacco use epidemic globally. This dissertation addresses the temporal relationship of tobacco use and its related diseases in three parts. First, the Tobacco Use Supplement of the Current Population Survey was used with joinpoint regression analysis to better understand trends and factors related to smokeless tobacco use (SLT) and cigarette smoking in the US. We found that while smoking continues to decrease, SLT has remained constant since the early 2000s. In addition, we found that while smoking cessation rates doubled from 2002 to 2010, SLT cessation rates remained constant. Second, individual smoking history information from the Nurses’ Health Study and Health Professionals’ Follow-up Study were used to develop and validate a COPD risk prediction model. By including detailed smoking information, we improved the model calibration and predictability. The resulting model was then used to investigate how time-varying cigarette smoking exposures, characterized by duration, intensity, time since quitting, determine COPD risk. Third, population-based cancer surveillance lung cancer data from four cancer registries were used to characterize and project sex-specific lung cancer incidence trends by histology in Thailand using joinpoint regression, age-period cohort, and Nordpred models. We found that lung cancer trends vary greatly by sex, region and histology, and projected rates of adenocarcinoma will continue to increase compared to those of squamous-cell carcinoma. This dissertation shows the benefits of, and need for, incorporating for the temporal aspects of tobacco exposure and disease outcomes, and provides examples of methodological approaches that can be used for the analysis of epidemiological time trends. Use of these and other methods is critical to properly assess the current and future burden of tobacco use, and the impact of interventions to reduce its burden. Advisors/Committee Members: Meza, Rafael (committee member), Banerjee, Mousumi (committee member), Arenberg, Douglas A (committee member), Jeon, Jihyoun (committee member), Levy, David T (committee member), Pearce, Celeste L (committee member).

Subjects/Keywords: Tobacco use; COPD; Lung cancer; Public Health; Health Sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chang, J. (2017). Characterizing the Temporal Aspects of Tobacco Use and Its Related Diseases. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/137154

Chicago Manual of Style (16^th Edition):

Chang, Joanne. “Characterizing the Temporal Aspects of Tobacco Use and Its Related Diseases.” 2017. Doctoral Dissertation, University of Michigan. Accessed March 04, 2021. http://hdl.handle.net/2027.42/137154.

MLA Handbook (7^th Edition):

Chang, Joanne. “Characterizing the Temporal Aspects of Tobacco Use and Its Related Diseases.” 2017. Web. 04 Mar 2021.

Vancouver:

Chang J. Characterizing the Temporal Aspects of Tobacco Use and Its Related Diseases. [Internet] [Doctoral dissertation]. University of Michigan; 2017. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/2027.42/137154.

Council of Science Editors:

Chang J. Characterizing the Temporal Aspects of Tobacco Use and Its Related Diseases. [Doctoral Dissertation]. University of Michigan; 2017. Available from: http://hdl.handle.net/2027.42/137154

University of Kansas

6. Taylor, Jane B. Impact of Intercurrent Respiratory Infections on Lung Health in Infants Born <29 Weeks with BPD.

Degree: MS, Clinical Research, 2013, University of Kansas

URL: http://hdl.handle.net/1808/14209

► Abstract: Objective: To assess the impact of intercurrent respiratory infections on infants born <29 weeks gestation with bronchopulmonary dysplasia (BPD). Study Design: A retrospective cohort… (more)

Subjects/Keywords: Medicine; Health sciences; Public health; Bacterial; Bronchopulmonary dysplAsia; Lung; Premature; Viral

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APA (6^th Edition):

Taylor, J. B. (2013). Impact of Intercurrent Respiratory Infections on Lung Health in Infants Born <29 Weeks with BPD. (Masters Thesis). University of Kansas. Retrieved from http://hdl.handle.net/1808/14209

Chicago Manual of Style (16^th Edition):

Taylor, Jane B. “Impact of Intercurrent Respiratory Infections on Lung Health in Infants Born <29 Weeks with BPD.” 2013. Masters Thesis, University of Kansas. Accessed March 04, 2021. http://hdl.handle.net/1808/14209.

MLA Handbook (7^th Edition):

Taylor, Jane B. “Impact of Intercurrent Respiratory Infections on Lung Health in Infants Born <29 Weeks with BPD.” 2013. Web. 04 Mar 2021.

Vancouver:

Taylor JB. Impact of Intercurrent Respiratory Infections on Lung Health in Infants Born <29 Weeks with BPD. [Internet] [Masters thesis]. University of Kansas; 2013. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1808/14209.

Council of Science Editors:

Taylor JB. Impact of Intercurrent Respiratory Infections on Lung Health in Infants Born <29 Weeks with BPD. [Masters Thesis]. University of Kansas; 2013. Available from: http://hdl.handle.net/1808/14209

University of South Carolina

7. Ersek, Jennifer Lynne. Utilization Of Lung Cancer Screening And Molecular Testing To Improve Lung Cancer Outcomes.

Degree: PhD, Epidemiology and Biostatistics, 2017, University of South Carolina

URL: https://scholarcommons.sc.edu/etd/4490

► Despite progress in detection and treatment, lung cancer remains the leading cause of cancer-related death in the United States. The United States Preventive Services… (more)

▼ Despite progress in detection and treatment, lung cancer remains the leading cause of cancer-related death in the United States. The United States Preventive Services Task Force (USPSTF) recommends adults at high risk for lung cancer undergo annual low-dose computed tomography (LDCT) screening, however, lung cancer screening (LCS) uptake remains low. Qualitative research on family physician (FP) perceptions and experiences with LCS has been limited since USPSTF publication and Centers for Medicare and Medicaid Services (CMS) decision memo. We conducted a qualitative study to assess FP knowledge and perceptions of LCS and gain insight into their current experiences with LDCT. A convenience sample of FPs were asked to participate in Skype audio interviews. A semi-structured interview guide was used to navigate the interviews. A theme codebook was developed using the constant comparison technique. All interviews were coded by two reviewers We found that FP knowledge about the scientific evidence and patient eligibility criteria for LDCT was suboptimal. Age and smoking history were the primary drivers of a FPs decision to discuss LCS. Most FPs knew that they should initiate LDCT discussions with high risk patients, however, they indicated that they would be willing to screen patients outside of the specified criteria. LDCT cost and lack of time were cited as barriers. Facilitators included screening tools in the clinic waiting room and electronic medical record notifications. These results indicate a need for FP education about LCS, as well as tools to assist providers in the clinic. As LCS becomes more widely adopted, more lung cancers will be detected at an earlier stage. While tumor molecular testing (MT) is currently recommended for patients with metastatic disease, MT could increasingly be used in early stage patients to guide initial treatment decisions. Disparities in MT and targeted therapy utilization may exist. We quantitatively evaluated factors related to MT and erlotinib utilization and the impact of these on overall survival (OS). Stage IIIB/IV non-small cell lung cancer (NSCLC) cases diagnosed between January 1, 2002 and December 31, 2012 and available through the South Carolina Central Cancer Registry were linked to SC State Employee Health Plan (SCSEHP) and Medicaid administrative claims data. MT and erlotinib utilization were independently categorized as “yes” or “no” based on claims data. We found several characteristics associated with MT, including younger age, having an out-of-state provider, being diagnosed in 2010 or later, adenocarcinoma histology, and low tumor grade. Risk of death was reduced and OS was longer for patients with MT. Younger age, female sex, SCSHEP insurance, having an out-of-state provider, adenocarcinoma histology, and having molecular testing were associated with erlotinib utilization. Risk of death was lower for patients treated with erlotinib and OS was longer. These results suggest that tumor MT and erlotinib utilization lead to improved patient… Advisors/Committee Members: Jan M. Eberth.

Subjects/Keywords: Epidemiology; Medicine and Health Sciences; Public Health; Utilization; Lung Cancer Screening; Molecular Testing; Improve Lung Cancer Outcomes

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APA (6^th Edition):

Ersek, J. L. (2017). Utilization Of Lung Cancer Screening And Molecular Testing To Improve Lung Cancer Outcomes. (Doctoral Dissertation). University of South Carolina. Retrieved from https://scholarcommons.sc.edu/etd/4490

Chicago Manual of Style (16^th Edition):

Ersek, Jennifer Lynne. “Utilization Of Lung Cancer Screening And Molecular Testing To Improve Lung Cancer Outcomes.” 2017. Doctoral Dissertation, University of South Carolina. Accessed March 04, 2021. https://scholarcommons.sc.edu/etd/4490.

MLA Handbook (7^th Edition):

Ersek, Jennifer Lynne. “Utilization Of Lung Cancer Screening And Molecular Testing To Improve Lung Cancer Outcomes.” 2017. Web. 04 Mar 2021.

Vancouver:

Ersek JL. Utilization Of Lung Cancer Screening And Molecular Testing To Improve Lung Cancer Outcomes. [Internet] [Doctoral dissertation]. University of South Carolina; 2017. [cited 2021 Mar 04]. Available from: https://scholarcommons.sc.edu/etd/4490.

Council of Science Editors:

Ersek JL. Utilization Of Lung Cancer Screening And Molecular Testing To Improve Lung Cancer Outcomes. [Doctoral Dissertation]. University of South Carolina; 2017. Available from: https://scholarcommons.sc.edu/etd/4490

Georgia Tech

8. Nevius, Brandi N. The Mechanical Design and Optimization of a Wearable Multimodal Health Sensing System.

Degree: MS, Mechanical Engineering, 2020, Georgia Tech

URL: http://hdl.handle.net/1853/64186

► It has been demonstrated that both acoustic measurements and bioimpedance spectroscopy can be useful for noninvasively monitoring the health of the human body, for instance… (more)

Subjects/Keywords: Wearable; Biomedical; Health; Sensing device; Joint health; COVID-19; Lung health; optimization; brace

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APA (6^th Edition):

Nevius, B. N. (2020). The Mechanical Design and Optimization of a Wearable Multimodal Health Sensing System. (Masters Thesis). Georgia Tech. Retrieved from http://hdl.handle.net/1853/64186

Chicago Manual of Style (16^th Edition):

Nevius, Brandi N. “The Mechanical Design and Optimization of a Wearable Multimodal Health Sensing System.” 2020. Masters Thesis, Georgia Tech. Accessed March 04, 2021. http://hdl.handle.net/1853/64186.

MLA Handbook (7^th Edition):

Nevius, Brandi N. “The Mechanical Design and Optimization of a Wearable Multimodal Health Sensing System.” 2020. Web. 04 Mar 2021.

Vancouver:

Nevius BN. The Mechanical Design and Optimization of a Wearable Multimodal Health Sensing System. [Internet] [Masters thesis]. Georgia Tech; 2020. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1853/64186.

Council of Science Editors:

Nevius BN. The Mechanical Design and Optimization of a Wearable Multimodal Health Sensing System. [Masters Thesis]. Georgia Tech; 2020. Available from: http://hdl.handle.net/1853/64186

Florida International University

9. Glaze, Joy Adella. The Lived Experiences of Caregivers of Lung Transplant Recipients.

Degree: PhD, Nursing, 2018, Florida International University

URL: https://digitalcommons.fiu.edu/etd/3683 ; 10.25148/etd.FIDC006913 ; FIDC006913

► Lung transplantation is a treatment for patients with end stage lung disease; they will not survive without such surgery. A caregiver is essential for… (more)

▼ Lung transplantation is a treatment for patients with end stage lung disease; they will not survive without such surgery. A caregiver is essential for a patient to become eligible for a lung transplant and the caregiver plays an essential role in the transplant recipient’s care both before and after transplant surgery. Most caregiver research has been conducted on caregivers of persons with Alzheimer’s disease, dementia or on elderly patients, however, it is important to examine caregivers’ experiences caring for other patient groups with disabling conditions. Caregivers of transplant recipients are one such group. The purpose of this qualitative study, using a hermeneutic phenomenological approach, was to examine the lived experiences of caregivers of lung transplant recipients pre- and post-lung transplantation. The study used semi- structured, face to face, tape recorded in- depth interviews to document the experiences of a purposive sampling of 20 caregivers of lung transplant recipients. Interviews (English, Spanish) were transcribed verbatim and analyzed for emerging themes. The resulting 4 themes and 12 sub themes were: 1) Establishing the diagnosis; 2) Caregivers roles; 3) Caregivers psychological and psychosocial Issues; and 4) Support. The 12 sub themes were:1) Caregivers reaction to transplant option; 2) Caregivers’ lack of basic knowledge as related to lung transplant 3) Disease progression: Reality of unanticipated changes/fear of death; 4) Pre- transplant experiences; 5) Hospital course; 6) Home care; 7) Lifestyle changes and Social activities;8) Physical health and Emotional health ; 9) Financial and Employment issues;10) Family/Friends;11) Professional support; 12) Support groups. Study results demonstrated caregivers’ lack of knowledge about transplantation, dramatic changes in caregivers ‘family life, social activities, employment, and often financial status. Results also demonstrated a need for health care providers and policy makers to recognize caregivers’ stressful life changes and implement informational, psychological and emotional interventions and policies to assist these caregivers during their stressful and tedious experiences. Advisors/Committee Members: Dorothy Brooten, JoAnne Youngblut, Jean Hannan, Timothy Page.

Subjects/Keywords: Lung transplant; Lung transplant recipient; Lung transplant caregiver; Caregivers' burden; Caregivers' role; Caregivers' health; Caregivers' gender; Informal caregivers; Phenomenology; Hermeneutic phenomenology; Medicine and Health Sciences; Nursing

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APA (6^th Edition):

Glaze, J. A. (2018). The Lived Experiences of Caregivers of Lung Transplant Recipients. (Doctoral Dissertation). Florida International University. Retrieved from https://digitalcommons.fiu.edu/etd/3683 ; 10.25148/etd.FIDC006913 ; FIDC006913

Chicago Manual of Style (16^th Edition):

Glaze, Joy Adella. “The Lived Experiences of Caregivers of Lung Transplant Recipients.” 2018. Doctoral Dissertation, Florida International University. Accessed March 04, 2021. https://digitalcommons.fiu.edu/etd/3683 ; 10.25148/etd.FIDC006913 ; FIDC006913.

MLA Handbook (7^th Edition):

Glaze, Joy Adella. “The Lived Experiences of Caregivers of Lung Transplant Recipients.” 2018. Web. 04 Mar 2021.

Vancouver:

Glaze JA. The Lived Experiences of Caregivers of Lung Transplant Recipients. [Internet] [Doctoral dissertation]. Florida International University; 2018. [cited 2021 Mar 04]. Available from: https://digitalcommons.fiu.edu/etd/3683 ; 10.25148/etd.FIDC006913 ; FIDC006913.

Council of Science Editors:

Glaze JA. The Lived Experiences of Caregivers of Lung Transplant Recipients. [Doctoral Dissertation]. Florida International University; 2018. Available from: https://digitalcommons.fiu.edu/etd/3683 ; 10.25148/etd.FIDC006913 ; FIDC006913

University of California – Berkeley

10. Gale, Sara Lynn. The Impact of Neighborhood Traffic Density and Deprivation on Lung Function Among Children with Asthma.

Degree: Epidemiology, 2012, University of California – Berkeley

URL: http://www.escholarship.org/uc/item/6h38n5tn

► To investigate the extent to which traffic exposure affects the lung function of children with asthma and how local neighborhood factors may modify this relation,… (more)

▼ To investigate the extent to which traffic exposure affects the lung function of children with asthma and how local neighborhood factors may modify this relation, a merge of epidemiologic, environmental health and geographic methods is necessary. People and places are linked; therefore, it is necessary to consider place-effects on health as well as environmental exposures. The Fresno Asthmatic Children's Environment Study (FACES) is a longitudinal cohort study of children with asthma in Fresno, California that followed participants from 2000-2008 to explore short-term and long-term effects of ambient air pollution on lung function (as measured by spirometry, wheeze, and asthma symptoms). With publicly available data on traffic counts in Fresno, CA from 2000-2008, I built a spatial model of traffic exposure that varies both temporally and spatially for the FACES cohort. To capture and quantify neighborhood characteristics, I constructed individual neighborhoods based on global positioning software (GPS) data and walking distances around participant homes. To evaluate neighborhood deprivation, I collected geographic information system (GIS) data on parks, grocery stores, bus stops, etc. from publicly available sources and created an index based on Item Response Theory. To assess the marginal risk difference of lung function among children with asthma exposed to high levels of traffic pollution and those exposed to lower levels of traffic pollution (as measured by traffic density), I apply semi-parametric causal inference methods and use Targeted Maximum Likelihood Estimation (TMLE). More FACES participants who live in high deprivation neighborhoods are also farther away from high traffic areas. Neighborhood deprivation, as defined by a combination of GIS variables in this study, does not track well with US Census poverty. The marginal change in lung function from exposure to high neighborhood traffic to lower neighborhood traffic, without stratification for neighborhood deprivation, is -0.233 (95% CI -0.338, -0.129). The results can be interpreted as – the average decrease of FEV1 is 0.233 L, or there is a 12% reduction in lung function. Either neighborhood deprivation does not modify the effect of traffic on lung function or there is not enough data to evaluate this type of effect modification. The findings indicate that neighborhood exposure to traffic adversely affects lung function among the FACES cohort of children with asthma.

Subjects/Keywords: Epidemiology; Environmental health; Air pollution; Asthma; Deprivation; Lung function; Neighborhood; Traffic

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gale, S. L. (2012). The Impact of Neighborhood Traffic Density and Deprivation on Lung Function Among Children with Asthma. (Thesis). University of California – Berkeley. Retrieved from http://www.escholarship.org/uc/item/6h38n5tn

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gale, Sara Lynn. “The Impact of Neighborhood Traffic Density and Deprivation on Lung Function Among Children with Asthma.” 2012. Thesis, University of California – Berkeley. Accessed March 04, 2021. http://www.escholarship.org/uc/item/6h38n5tn.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gale, Sara Lynn. “The Impact of Neighborhood Traffic Density and Deprivation on Lung Function Among Children with Asthma.” 2012. Web. 04 Mar 2021.

Vancouver:

Gale SL. The Impact of Neighborhood Traffic Density and Deprivation on Lung Function Among Children with Asthma. [Internet] [Thesis]. University of California – Berkeley; 2012. [cited 2021 Mar 04]. Available from: http://www.escholarship.org/uc/item/6h38n5tn.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gale SL. The Impact of Neighborhood Traffic Density and Deprivation on Lung Function Among Children with Asthma. [Thesis]. University of California – Berkeley; 2012. Available from: http://www.escholarship.org/uc/item/6h38n5tn

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

11. Gazala, Sayf. The Relationship between Health Related Quality of Life and Non-Small Cell Lung Cancer Surgery.

Degree: MS, School Public Health Sciences, 2012, University of Alberta

URL: https://era.library.ualberta.ca/files/nk322f81n

► Objectives: To review the studies those have assessed Quality Of Life (QOL) after Video Assisted Thoracoscopic Surgery (VATS) and Thoracotomy for resection of lung cancer,… (more)

Subjects/Keywords: Lung Cancer; Health Related Quality of Life; Video Assisted Thoracoscopic Surgery

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APA (6^th Edition):

Gazala, S. (2012). The Relationship between Health Related Quality of Life and Non-Small Cell Lung Cancer Surgery. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/nk322f81n

Chicago Manual of Style (16^th Edition):

Gazala, Sayf. “The Relationship between Health Related Quality of Life and Non-Small Cell Lung Cancer Surgery.” 2012. Masters Thesis, University of Alberta. Accessed March 04, 2021. https://era.library.ualberta.ca/files/nk322f81n.

MLA Handbook (7^th Edition):

Gazala, Sayf. “The Relationship between Health Related Quality of Life and Non-Small Cell Lung Cancer Surgery.” 2012. Web. 04 Mar 2021.

Vancouver:

Gazala S. The Relationship between Health Related Quality of Life and Non-Small Cell Lung Cancer Surgery. [Internet] [Masters thesis]. University of Alberta; 2012. [cited 2021 Mar 04]. Available from: https://era.library.ualberta.ca/files/nk322f81n.

Council of Science Editors:

Gazala S. The Relationship between Health Related Quality of Life and Non-Small Cell Lung Cancer Surgery. [Masters Thesis]. University of Alberta; 2012. Available from: https://era.library.ualberta.ca/files/nk322f81n

Temple University

12. Malone, Daniel Joseph. PERFLUOROCHEMICAL AUGMENTED INTRATRACHEAL DELIVERY OF ANTIOXIDANT ENZYMES AND GENES TO ATTENUATE OXIDATIVE STRESS-INDUCED LUNG AND RESPIRATORY MUSCLE ALTERATIONS.

Degree: PhD, 2009, Temple University

URL: http://digital.library.temple.edu/u?/p245801coll10,24041

►

Physiology

Supraphysiologic concentrations of oxygen are used in the management of critically ill patients across the lifespan. However, hyperoxia (HO) results in alveolar- capillary membrane… (more)

▼

Physiology

Supraphysiologic concentrations of oxygen are used in the management of critically ill patients across the lifespan. However, hyperoxia (HO) results in alveolar- capillary membrane destruction, pulmonary edema, pleural effusions, infiltration and activation of inflammatory cells, altered pulmonary mechanics and gas exchange prompting increased loading of the respiratory muscle. These abnormalities of pulmonary structure and function increase the work of breathing necessitating increased respiratory muscle force production to maintain alveolar ventilation. When the load placed on the respiratory muscle pump exceeds its capacity, respiratory failure develops and is ultimately fatal unless therapeutic interventions are able to reduce the ventilatory load. The use of perfluorochemical (PFC) liquids as a respiratory medium has been effective in the treatment of respiratory distress syndrome and acute lung injury (ALI) requiring mechanical ventilation. Mechanistically, by eliminating the air-liquid interface, PFC liquids reduce surface tension enabling lung volume recruitment at low inspiratory pressures and have high respiratory gas solubility which supports gas exchange. Additionally, through mechanical as well as cytoprotective mechanisms, intrapulmonary PFC liquids reduce inflammatory cell activation and recruitment. Cell culture, animal and human studies have suggested that acute and chronic lung injury secondary to prolonged HO may be ameliorated by administration of antioxidant enzymes (AOE), with superoxide dismutases (SOD) having significant protective effects. Because the lung is exposed to the highest O2 concentrations, a logical strategy to reduce HO-induced damage is to specifically target antioxidant enzymes to the lungs. However, intratracheal delivery of AOE by vehicles like normal saline may transiently impair lung function and be poorly distributed. PFC fluids have previously been shown to be effective respiratory media for pulmonary administration of various drugs. The premise of the proposed studies are to to characterize hyperoxic lung injury in a spontaneously breathing animal model and to develop therapeutic strategies to reduce oxidatative stress and supplement endogenous AOE. With respect to the diaphragm, we reason that HO-induced lung damage and oxidative stress will increase contractile demand of the diaphragm. If AOE activity could be increased in the lungs and respiratory muscles with AOE proteins or the genes encoding these enzymes, then cell damage, inflammatory changes, damage to the lung and respiratory "pump" might be ameliorated or prevented. The results show that PFC and SOD can attenuate the HO- induced decline in lung mechanics and gas exchange, ameliorate the inflammatory and oxidative stress profiles, and promote lung and muscle structural integrity resulting in a survival benefit. These findings support the novel application of PFC liquids in a spontaneously breathing model and support the concept that PFC preconditioning and AOE supplementation play a protective…

Advisors/Committee Members: Wolfson, Marla R., Shaffer, Thomas H., Autieri, Michael V., Barbe, Mary F., Kazzaz, Jeffery A..

Subjects/Keywords: Biology, Physiology; Health Sciences, Medicine and Surgery; diaphragm; hyperoxia; lung injury

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Malone, D. J. (2009). PERFLUOROCHEMICAL AUGMENTED INTRATRACHEAL DELIVERY OF ANTIOXIDANT ENZYMES AND GENES TO ATTENUATE OXIDATIVE STRESS-INDUCED LUNG AND RESPIRATORY MUSCLE ALTERATIONS. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,24041

Chicago Manual of Style (16^th Edition):

Malone, Daniel Joseph. “PERFLUOROCHEMICAL AUGMENTED INTRATRACHEAL DELIVERY OF ANTIOXIDANT ENZYMES AND GENES TO ATTENUATE OXIDATIVE STRESS-INDUCED LUNG AND RESPIRATORY MUSCLE ALTERATIONS.” 2009. Doctoral Dissertation, Temple University. Accessed March 04, 2021. http://digital.library.temple.edu/u?/p245801coll10,24041.

MLA Handbook (7^th Edition):

Malone, Daniel Joseph. “PERFLUOROCHEMICAL AUGMENTED INTRATRACHEAL DELIVERY OF ANTIOXIDANT ENZYMES AND GENES TO ATTENUATE OXIDATIVE STRESS-INDUCED LUNG AND RESPIRATORY MUSCLE ALTERATIONS.” 2009. Web. 04 Mar 2021.

Vancouver:

Malone DJ. PERFLUOROCHEMICAL AUGMENTED INTRATRACHEAL DELIVERY OF ANTIOXIDANT ENZYMES AND GENES TO ATTENUATE OXIDATIVE STRESS-INDUCED LUNG AND RESPIRATORY MUSCLE ALTERATIONS. [Internet] [Doctoral dissertation]. Temple University; 2009. [cited 2021 Mar 04]. Available from: http://digital.library.temple.edu/u?/p245801coll10,24041.

Council of Science Editors:

Malone DJ. PERFLUOROCHEMICAL AUGMENTED INTRATRACHEAL DELIVERY OF ANTIOXIDANT ENZYMES AND GENES TO ATTENUATE OXIDATIVE STRESS-INDUCED LUNG AND RESPIRATORY MUSCLE ALTERATIONS. [Doctoral Dissertation]. Temple University; 2009. Available from: http://digital.library.temple.edu/u?/p245801coll10,24041

University of Louisville

13. Zimmaro, Lauren Ann. Understanding the relationship between positive affect and cortisol in lung cancer patients.

Degree: PhD, 2018, University of Louisville

URL: 10.18297/etd/3047 ; https://ir.library.louisville.edu/etd/3047

► Positive psychobiological processes within lung cancer patients are drastically understudied. This dissertation explores the nature of positive affect (PA) and potential associations with diurnal… (more)

▼ Positive psychobiological processes within lung cancer patients are drastically understudied. This dissertation explores the nature of positive affect (PA) and potential associations with diurnal cortisol among lung cancer patients, given the prognostic significance of diurnal cortisol rhythms. Theoretical underpinnings and current literature involving PA, cancer, and diurnal cortisol are first reviewed. An original integrated model of PA and cortisol among cancer patients is then presented, from which the proposed dissertation study and analyses are derived. Sixty-one non-small cell lung cancer patients provided self-report assessment of mood (PANAS PA and NA subscales, CES-D PA subscale), medical and demographic characteristics, and 10-day salivary cortisol. Aim 1 tested hypotheses that: (1) patients will experience moderate PA, and more PA than NA, (2) PA and NA will emerge as separate factors in factor analyses, and (3) higher PA will correlate with variables reflecting lower disease burden. Aim 1 was assessed through descriptive statistics, correlations, t-tests, and exploratory factor analyses. Aim 2 tested hypotheses that: (1) higher PA will relate to lower cortisol means, (2) higher PA will relate to steeper diurnal �� slope, (3) PA will relate more strongly to overall mean cortisol than diurnal slope. Aim 2 was tested through hierarchical linear regressions and path analyses. Aim 1 results showed that patients generally held positive emotions and endorsed PA items that reflected determination and resilience. They also reported more PA than NA; these two constructs emerged as separate and distinct factors. Race, smoking, and current treatment all significantly related to PA. Aim 2 revealed that PA did not significantly associate with mean cortisol variables or diurnal slope. However, higher NA was associated with flattened slopes, after excluding patients taking corticosteroids. Although the relationship between PA and mean cortisol was consistently stronger than with diurnal slope in path analyses, the associations were non-significant. Patients reported experiencing positive emotions that may reflect resilience and adaptive coping. Positive affect did not have strong associations with cortisol, which may be due to pre-existing cortisol dysregulation or small sample size. Future studies should continue to explore mind-body associations of positive psychological processes in lung cancer patients. Advisors/Committee Members: Sephton, Sandra, Salmon, Paul, Salmon, Paul, Mast, Benjamin, Woodruff-Borden, Janet, Newton, Tamara, Cash, Elizabeth.

Subjects/Keywords: cortisol; lung cancer; positive affect; cancer patient; Clinical Psychology; Health Psychology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zimmaro, L. A. (2018). Understanding the relationship between positive affect and cortisol in lung cancer patients. (Doctoral Dissertation). University of Louisville. Retrieved from 10.18297/etd/3047 ; https://ir.library.louisville.edu/etd/3047

Chicago Manual of Style (16^th Edition):

Zimmaro, Lauren Ann. “Understanding the relationship between positive affect and cortisol in lung cancer patients.” 2018. Doctoral Dissertation, University of Louisville. Accessed March 04, 2021. 10.18297/etd/3047 ; https://ir.library.louisville.edu/etd/3047.

MLA Handbook (7^th Edition):

Zimmaro, Lauren Ann. “Understanding the relationship between positive affect and cortisol in lung cancer patients.” 2018. Web. 04 Mar 2021.

Vancouver:

Zimmaro LA. Understanding the relationship between positive affect and cortisol in lung cancer patients. [Internet] [Doctoral dissertation]. University of Louisville; 2018. [cited 2021 Mar 04]. Available from: 10.18297/etd/3047 ; https://ir.library.louisville.edu/etd/3047.

Council of Science Editors:

Zimmaro LA. Understanding the relationship between positive affect and cortisol in lung cancer patients. [Doctoral Dissertation]. University of Louisville; 2018. Available from: 10.18297/etd/3047 ; https://ir.library.louisville.edu/etd/3047

Texas Medical Center

14. Zhang, Fanmao. Novel serum biomarkers for lung cancer early diagnosis and clinical outcome.

Degree: PhD, 2014, Texas Medical Center

URL: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/477

► The five-year survival rate for all stages of lung cancer combined is only 17%, which has changed little over the past 40 years. Despite… (more)

▼ The five-year survival rate for all stages of lung cancer combined is only 17%, which has changed little over the past 40 years. Despite the tremendous efforts made, serum biomarkers with clinical utility for lung cancer early detection and clinical outcome prediction are still lacking. Metabolic alterations have been recognized as an emerging hallmark of cancer. We aimed to investigate the metabolic changes associated with lung cancer and to identify novel clinically applicable serum biomarkers for lung cancer early diagnosis and clinical outcome. Serum metabolites are potential biomarkers for lung cancer early detection. We first performed global metabolomic profiling followed by targeted validation of individual metabolites in a case-control design of 386 lung cancer cases and 193 matched controls. We then validated the most significant metabolite bilirubin as a risk marker for lung cancer incidence and mortality in a large prospective cohort comprised of 425,660 participants. In this cohort, the inverse association was only seen in male smokers. For every 0.1 mg/dL decrease of bilirubin, the risks for lung cancer incidence and mortality increased by 5% and 6%, respectively (both P < 0.001). We next investigated pre-treatment laboratory tests indicative of a patient’s overall metabolic status, as biomarkers for non-small cell lung cancer (NSCLC) clinical outcome. We assessed seven pre-treatment serum laboratory test levels in 2,675 NSCLC patients, including 623 early stage and 2,052 advanced stage patients. Among 978 advanced stage NSCLC patients we studied who were treated with platinum-based chemotherapy, lower than normal levels of albumin, higher than normal levels of alkaline phosphatase and lactate dehydrogenase were all associated with worse 2-year overall survival, after adjusting for other variables. In addition, there was a cumulative effect among these three adverse laboratory test levels. In conclusion, low serum bilirubin levels are associated with higher risks of lung cancer incidence and mortality in male smokers and may be used to identify higher risk smokers for lung cancer. In addition, pre-treatment laboratory test levels indicative of metabolic status could be utilized to enhance predictions of survival among advanced stage NSCLC patients treated with platinum-based chemotherapy. Taken together, our results suggested that metabolic alterations associated with lung cancer could serve as novel serum biomarkers with clinical significance for lung cancer early detection and clinical outcome. Advisors/Committee Members: Xifeng Wu, Paul Chiao, Jian Gu.

Subjects/Keywords: Lung cancer; serum biomarker; metabolism; Epidemiology; Medicine and Health Sciences; Oncology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zhang, F. (2014). Novel serum biomarkers for lung cancer early diagnosis and clinical outcome. (Doctoral Dissertation). Texas Medical Center. Retrieved from https://digitalcommons.library.tmc.edu/utgsbs_dissertations/477

Chicago Manual of Style (16^th Edition):

Zhang, Fanmao. “Novel serum biomarkers for lung cancer early diagnosis and clinical outcome.” 2014. Doctoral Dissertation, Texas Medical Center. Accessed March 04, 2021. https://digitalcommons.library.tmc.edu/utgsbs_dissertations/477.

MLA Handbook (7^th Edition):

Zhang, Fanmao. “Novel serum biomarkers for lung cancer early diagnosis and clinical outcome.” 2014. Web. 04 Mar 2021.

Vancouver:

Zhang F. Novel serum biomarkers for lung cancer early diagnosis and clinical outcome. [Internet] [Doctoral dissertation]. Texas Medical Center; 2014. [cited 2021 Mar 04]. Available from: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/477.

Council of Science Editors:

Zhang F. Novel serum biomarkers for lung cancer early diagnosis and clinical outcome. [Doctoral Dissertation]. Texas Medical Center; 2014. Available from: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/477

Texas Medical Center

15. Wang, Yifan. ENHANCING RADIATION SENSITIVITY IN NON-SMALL CELL LUNG CANCER.

Degree: PhD, 2018, Texas Medical Center

URL: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/884

► Lung cancer is the leading cause of cancer-related death. While radiation therapy is one of the standard treatments for lung cancer, the disease outcome… (more)

▼ Lung cancer is the leading cause of cancer-related death. While radiation therapy is one of the standard treatments for lung cancer, the disease outcome after radiotherapy is still far from satisfactory despite ongoing advances in radiation techniques. Enhancing the radiosensitivity of lung cancer has the potential to improve the disease outcome of radiation treatments. Using a novel high throughput radiation sensitizing screen, previous work in the lab has identified several potent radiation sensitizers. The focus of my dissertation is on two of the identified pathways, HSP90 and MEK, using the potent and clinically relevant inhibitors ganetespib and trametinib. Using both in vitro experiments in multiple non-small cell lung cancer (NSCLC) cell lines and in vivo experiments in animal models, I tested the ability of these inhibitors to radiosensitize lung tumors in the clinically relevant context of chemoradiation. I have found that ganetespib sensitized lung cancer cells to radiation through attenuating DNA damage repair through attenuating DNA damage repair and accentuating G2-M cell cycle arrest. However, when combined with chemoradiation in vivo, ganetespib has variable effects on different cells. For radiation sensitization through MEK inhibition, I found that trametinib selectively sensitized KRAS-LKB1 co-mutant NSCLC, but not KRAS-TP53 mutant cells, through radiation-induced senescence. In the LKB1 wild type background, trametinib and radiation activated AMPK-autophagy pathway to rescue cells from senescence, therefore conferring resistance to the radiosensitization. In summary, my studies which focused on how these two specific targeted pathways caused radiation sensitization emphasized the need to better understand the molecular and signaling complexities in determining radiation sensitization effects especially when multiple modalities are combined. Preclinical studies in the context of clinically relevant treatment settings are warranted for optimal clinical translation and personalized cancer therapy. Advisors/Committee Members: Steven H. Lin, M.D., Ph.D., Junjie Chen, Ph.D., Lei Li, Ph.D..

Subjects/Keywords: lung cancer; radiotherapy; radio sensitization; KRAS; LKB1; Medicine and Health Sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wang, Y. (2018). ENHANCING RADIATION SENSITIVITY IN NON-SMALL CELL LUNG CANCER. (Doctoral Dissertation). Texas Medical Center. Retrieved from https://digitalcommons.library.tmc.edu/utgsbs_dissertations/884

Chicago Manual of Style (16^th Edition):

Wang, Yifan. “ENHANCING RADIATION SENSITIVITY IN NON-SMALL CELL LUNG CANCER.” 2018. Doctoral Dissertation, Texas Medical Center. Accessed March 04, 2021. https://digitalcommons.library.tmc.edu/utgsbs_dissertations/884.

MLA Handbook (7^th Edition):

Wang, Yifan. “ENHANCING RADIATION SENSITIVITY IN NON-SMALL CELL LUNG CANCER.” 2018. Web. 04 Mar 2021.

Vancouver:

Wang Y. ENHANCING RADIATION SENSITIVITY IN NON-SMALL CELL LUNG CANCER. [Internet] [Doctoral dissertation]. Texas Medical Center; 2018. [cited 2021 Mar 04]. Available from: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/884.

Council of Science Editors:

Wang Y. ENHANCING RADIATION SENSITIVITY IN NON-SMALL CELL LUNG CANCER. [Doctoral Dissertation]. Texas Medical Center; 2018. Available from: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/884

16. Lynn, Thérése Marion. The Role of Bone Morphogenetic Protein Signalling in Adult Lung Health and Disease.

Degree: 2015, RIAN

URL: http://eprints.maynoothuniversity.ie/7084/

► Bone morphogenetic protein (BMP) signalling is essential for correct lung morphogenesis. The pathway controls branching morphogenesis in the nascent lung and is also involved in… (more)

▼ Bone morphogenetic protein (BMP) signalling is essential for correct lung morphogenesis. The pathway controls branching morphogenesis in the nascent lung and is also involved in the establishment of correct epithelial cell distribution throughout the airways. In the adult lung, BMP signalling is reactivated during airway injury and inflammation and there is evidence of aberrant signalling in lung cancer and in chronic lung diseases such as asthma and fibrosis. However, little is known about the role of BMP signalling in healthy adult airways. Furthermore the effect of incorrect BMP pathway expression during epithelial repair and inflammatory and malignant lung diseases remains elusive. The aims of this project were to characterise BMP pathway expression in the descending airways of large animal models and to investigate the role of BMP signalling during adult airway homeostasis, recovery and disease. To investigate the role of BMP signalling in malignant lung disease we used a heterogeneous lung cancer cell line DLKP. We explored the effect of the BMP pathway on epithelial-to-mesenchymal (EMT) progression and phenotypic plasticity between the tumour subpopulations. BMP-4 treatment induced mesenchymal-like projections in the DLKP-SQ clones and significant morphological changes in the DLKP-M clones towards the stem-cell like colonies of DLKP-I populations. Elevated N-cadherin and Vimentin protein expression was also evident in the clones following BMP-4 treatment. By stably transfecting an E-cadherin gene in these E-cadherin-null cells we demonstrated the distinct phenotypic differences between these tumour subpopulations. Healthy porcine and rhesus macaque lungs were used to characterise BMP pathway expression throughout the airways. Active BMP signalling was present in the descending airway epithelium and a gradient in pathway activation along the proximal-distal axis of the lungs was observed [1]. Using a primary porcine tracheal in vitro explant model the BMP signalling gradient was investigated further and it was found that by modulating BMP signalling, using exogenous BMP-4 stimulation, the epithelial phenotype of the porcine tracheal cells was altered. Finally, to assess the role of BMP signalling during airway inflammation and repair an established non-human primate model of allergic airway disease was used. A reduction in pSMAD1/5/8 expression was present in the epithelium of asthmatic monkeys compared to healthy controls. In addition, following a period of six months in filtered air to facilitate airway repair, there was a significant increase in Proliferating Cell Nuclear Antigen (PCNA), BMP Receptor 1a (BMPRIa) and pSMAD1/5/8 throughout the asthmatic airways. Taken together, these data suggest that not only is the developmental pathway re-activated during inflammatory airway disease but that basal BMP pathway expression is important for maintaining healthy airways. Overall these data highlight the presence and importance of BMP signalling gradients in healthy adult airways and further implicate BMP…

Subjects/Keywords: Bone Morphogenetic Protein Signalling; Adult Lung Health; Disease

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lynn, T. M. (2015). The Role of Bone Morphogenetic Protein Signalling in Adult Lung Health and Disease. (Thesis). RIAN. Retrieved from http://eprints.maynoothuniversity.ie/7084/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lynn, Thérése Marion. “The Role of Bone Morphogenetic Protein Signalling in Adult Lung Health and Disease.” 2015. Thesis, RIAN. Accessed March 04, 2021. http://eprints.maynoothuniversity.ie/7084/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lynn, Thérése Marion. “The Role of Bone Morphogenetic Protein Signalling in Adult Lung Health and Disease.” 2015. Web. 04 Mar 2021.

Vancouver:

Lynn TM. The Role of Bone Morphogenetic Protein Signalling in Adult Lung Health and Disease. [Internet] [Thesis]. RIAN; 2015. [cited 2021 Mar 04]. Available from: http://eprints.maynoothuniversity.ie/7084/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lynn TM. The Role of Bone Morphogenetic Protein Signalling in Adult Lung Health and Disease. [Thesis]. RIAN; 2015. Available from: http://eprints.maynoothuniversity.ie/7084/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

17. Lynn, Thérése Marion. The Role of Bone Morphogenetic Protein Signalling in Adult Lung Health and Disease.

Degree: 2015, RIAN

URL: http://mural.maynoothuniversity.ie/7084/

► Bone morphogenetic protein (BMP) signalling is essential for correct lung morphogenesis. The pathway controls branching morphogenesis in the nascent lung and is also involved in… (more)

▼ Bone morphogenetic protein (BMP) signalling is essential for correct lung morphogenesis. The pathway controls branching morphogenesis in the nascent lung and is also involved in the establishment of correct epithelial cell distribution throughout the airways. In the adult lung, BMP signalling is reactivated during airway injury and inflammation and there is evidence of aberrant signalling in lung cancer and in chronic lung diseases such as asthma and fibrosis. However, little is known about the role of BMP signalling in healthy adult airways. Furthermore the effect of incorrect BMP pathway expression during epithelial repair and inflammatory and malignant lung diseases remains elusive. The aims of this project were to characterise BMP pathway expression in the descending airways of large animal models and to investigate the role of BMP signalling during adult airway homeostasis, recovery and disease. To investigate the role of BMP signalling in malignant lung disease we used a heterogeneous lung cancer cell line DLKP. We explored the effect of the BMP pathway on epithelial-to-mesenchymal (EMT) progression and phenotypic plasticity between the tumour subpopulations. BMP-4 treatment induced mesenchymal-like projections in the DLKP-SQ clones and significant morphological changes in the DLKP-M clones towards the stem-cell like colonies of DLKP-I populations. Elevated N-cadherin and Vimentin protein expression was also evident in the clones following BMP-4 treatment. By stably transfecting an E-cadherin gene in these E-cadherin-null cells we demonstrated the distinct phenotypic differences between these tumour subpopulations. Healthy porcine and rhesus macaque lungs were used to characterise BMP pathway expression throughout the airways. Active BMP signalling was present in the descending airway epithelium and a gradient in pathway activation along the proximal-distal axis of the lungs was observed [1]. Using a primary porcine tracheal in vitro explant model the BMP signalling gradient was investigated further and it was found that by modulating BMP signalling, using exogenous BMP-4 stimulation, the epithelial phenotype of the porcine tracheal cells was altered. Finally, to assess the role of BMP signalling during airway inflammation and repair an established non-human primate model of allergic airway disease was used. A reduction in pSMAD1/5/8 expression was present in the epithelium of asthmatic monkeys compared to healthy controls. In addition, following a period of six months in filtered air to facilitate airway repair, there was a significant increase in Proliferating Cell Nuclear Antigen (PCNA), BMP Receptor 1a (BMPRIa) and pSMAD1/5/8 throughout the asthmatic airways. Taken together, these data suggest that not only is the developmental pathway re-activated during inflammatory airway disease but that basal BMP pathway expression is important for maintaining healthy airways. Overall these data highlight the presence and importance of BMP signalling gradients in healthy adult airways and further implicate BMP…

Subjects/Keywords: Bone Morphogenetic Protein Signalling; Adult Lung Health; Disease

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lynn, T. M. (2015). The Role of Bone Morphogenetic Protein Signalling in Adult Lung Health and Disease. (Thesis). RIAN. Retrieved from http://mural.maynoothuniversity.ie/7084/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lynn, Thérése Marion. “The Role of Bone Morphogenetic Protein Signalling in Adult Lung Health and Disease.” 2015. Thesis, RIAN. Accessed March 04, 2021. http://mural.maynoothuniversity.ie/7084/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lynn, Thérése Marion. “The Role of Bone Morphogenetic Protein Signalling in Adult Lung Health and Disease.” 2015. Web. 04 Mar 2021.

Vancouver:

Lynn TM. The Role of Bone Morphogenetic Protein Signalling in Adult Lung Health and Disease. [Internet] [Thesis]. RIAN; 2015. [cited 2021 Mar 04]. Available from: http://mural.maynoothuniversity.ie/7084/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lynn TM. The Role of Bone Morphogenetic Protein Signalling in Adult Lung Health and Disease. [Thesis]. RIAN; 2015. Available from: http://mural.maynoothuniversity.ie/7084/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Georgia State University

18. Neal, Fredrick. GEOGRAPHIC VARIATION OF RADON GAS CONCENTRATIONS IN RELATIONSHIP TO HOUSING CHARACTERISTICS IN DEKALB COUNTY, GEORGIA.

Degree: MS, Geosciences, 2016, Georgia State University

URL: https://scholarworks.gsu.edu/geosciences_theses/104

► Radon (RN-222), naturally released from underground, is the second leading cause of lung cancer for at-risk groups after smoking, and the leading cause of… (more)

Subjects/Keywords: Radon; GIS; Indoor air pollution; Lung cancer; Environmental health; Spatial autocorrelation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Neal, F. (2016). GEOGRAPHIC VARIATION OF RADON GAS CONCENTRATIONS IN RELATIONSHIP TO HOUSING CHARACTERISTICS IN DEKALB COUNTY, GEORGIA. (Thesis). Georgia State University. Retrieved from https://scholarworks.gsu.edu/geosciences_theses/104

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Neal, Fredrick. “GEOGRAPHIC VARIATION OF RADON GAS CONCENTRATIONS IN RELATIONSHIP TO HOUSING CHARACTERISTICS IN DEKALB COUNTY, GEORGIA.” 2016. Thesis, Georgia State University. Accessed March 04, 2021. https://scholarworks.gsu.edu/geosciences_theses/104.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Neal, Fredrick. “GEOGRAPHIC VARIATION OF RADON GAS CONCENTRATIONS IN RELATIONSHIP TO HOUSING CHARACTERISTICS IN DEKALB COUNTY, GEORGIA.” 2016. Web. 04 Mar 2021.

Vancouver:

Neal F. GEOGRAPHIC VARIATION OF RADON GAS CONCENTRATIONS IN RELATIONSHIP TO HOUSING CHARACTERISTICS IN DEKALB COUNTY, GEORGIA. [Internet] [Thesis]. Georgia State University; 2016. [cited 2021 Mar 04]. Available from: https://scholarworks.gsu.edu/geosciences_theses/104.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Neal F. GEOGRAPHIC VARIATION OF RADON GAS CONCENTRATIONS IN RELATIONSHIP TO HOUSING CHARACTERISTICS IN DEKALB COUNTY, GEORGIA. [Thesis]. Georgia State University; 2016. Available from: https://scholarworks.gsu.edu/geosciences_theses/104

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Kentucky

19. Levy, Adam J. Laboratory Performance Comparison of Vortecone Inertial Dust Scrubber to Flooded-Bed Dust Scrubber.

Degree: 2017, University of Kentucky

URL: https://uknowledge.uky.edu/mng_etds/33

► Increasing incidence of Black Lung disease in miners since the early 1990s has concerned law makers and the mining industry. New regulations promulgated by MSHA… (more)

Subjects/Keywords: Respirable Dust; Black Lung; Vortecone; Health and Safety; Mining Engineering

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Levy, A. J. (2017). Laboratory Performance Comparison of Vortecone Inertial Dust Scrubber to Flooded-Bed Dust Scrubber. (Masters Thesis). University of Kentucky. Retrieved from https://uknowledge.uky.edu/mng_etds/33

Chicago Manual of Style (16^th Edition):

Levy, Adam J. “Laboratory Performance Comparison of Vortecone Inertial Dust Scrubber to Flooded-Bed Dust Scrubber.” 2017. Masters Thesis, University of Kentucky. Accessed March 04, 2021. https://uknowledge.uky.edu/mng_etds/33.

MLA Handbook (7^th Edition):

Levy, Adam J. “Laboratory Performance Comparison of Vortecone Inertial Dust Scrubber to Flooded-Bed Dust Scrubber.” 2017. Web. 04 Mar 2021.

Vancouver:

Levy AJ. Laboratory Performance Comparison of Vortecone Inertial Dust Scrubber to Flooded-Bed Dust Scrubber. [Internet] [Masters thesis]. University of Kentucky; 2017. [cited 2021 Mar 04]. Available from: https://uknowledge.uky.edu/mng_etds/33.

Council of Science Editors:

Levy AJ. Laboratory Performance Comparison of Vortecone Inertial Dust Scrubber to Flooded-Bed Dust Scrubber. [Masters Thesis]. University of Kentucky; 2017. Available from: https://uknowledge.uky.edu/mng_etds/33

20. Santos, Abigail. Coffee and Tea Consumption and the Risk of Lung Cancer in a Population of Postmenopausal Women.

Degree: University of Massachusetts

URL: https://scholarworks.umass.edu/masters_theses_2/42

► Lung cancer has been the leading cause of cancer death in women for the past three decades. Although smoking is the most important risk… (more)

Subjects/Keywords: lung cancer; women; Women's Health

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Santos, A. (n.d.). Coffee and Tea Consumption and the Risk of Lung Cancer in a Population of Postmenopausal Women. (Thesis). University of Massachusetts. Retrieved from https://scholarworks.umass.edu/masters_theses_2/42

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Santos, Abigail. “Coffee and Tea Consumption and the Risk of Lung Cancer in a Population of Postmenopausal Women.” Thesis, University of Massachusetts. Accessed March 04, 2021. https://scholarworks.umass.edu/masters_theses_2/42.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Santos, Abigail. “Coffee and Tea Consumption and the Risk of Lung Cancer in a Population of Postmenopausal Women.” Web. 04 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Santos A. Coffee and Tea Consumption and the Risk of Lung Cancer in a Population of Postmenopausal Women. [Internet] [Thesis]. University of Massachusetts; [cited 2021 Mar 04]. Available from: https://scholarworks.umass.edu/masters_theses_2/42.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Santos A. Coffee and Tea Consumption and the Risk of Lung Cancer in a Population of Postmenopausal Women. [Thesis]. University of Massachusetts; Available from: https://scholarworks.umass.edu/masters_theses_2/42

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

University of Manchester

21. Wright, Stuart James. Accounting for Capacity Constraints in Economic Evaluations of Precision Medicine.

Degree: 2020, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:326430

► Background Precision medicine involves the use of tests, algorithms, or other information to target treatments to improve benefits or avoid harm for patients. Examples of… (more)

▼ Background Precision medicine involves the use of tests, algorithms, or other information to target treatments to improve benefits or avoid harm for patients. Examples of precision medicine represent complex interventions and there are many barriers, or health system capacity constraints (hereafter "capacity constraints"), to their introduction into clinical practice. The assumptions underlying economic evaluations of healthcare interventions do not currently allow for the incorporation and measurement of the impact of capacity constraints. The overall aim of this PhD was to identify and quantify the impact of including capacity constraints in decision-analytic model-based cost-effectiveness analysis to better inform resource allocation decisions and the introduction of precision medicine into clinical practice. Methods This thesis comprised six empirical chapters using different methods. A systematic review of systematic reviews (meta-review) was used to identify existing economic evaluations of precision medicine to determine if and how these studies quantified the impact of capacity constraints. Static and dynamic value of implementation methods were adapted to allow for the varying marginal costs and benefits which may arise due to health system capacity constraints and these methods were applied to a case study in breast cancer. To develop a typology of barriers to the introduction of examples of precision medicine, qualitative interviews were conducted with stakeholders in the implementation of examples of precision medicine in non-small cell lung cancer. A case study example of precision medicine was selected based on these interviews and a base case decision analytic model, replicating a published technology appraisal conducted by the National Institute for Health and Care Excellence (NICE), was created to evaluate the cost-effectiveness of immunohistochemistry (IHC) and fluorescent in-situ hybridisation (FISH) testing for anaplastic lymphoma kinase (ALK) alterations to guide treatment with crizotinib or docetaxel. Three capacity constraints were selected based on the qualitative interviews and these were incorporated into the base case model. The impact of these capacity constraints was quantified using static value of implementation methods. Hypothetical investments to reduce the impact of the capacity constraints were proposed and their potential value was determined using dynamic value of implementation methods. Results The meta-review identified 45 previous reviews of economic evaluations of precision medicine from which a sample of 222 economic evaluations focusing on "test-treat" interventions were selected. Of these, 33 studies qualitatively discussed potential capacity constraints and nine studies attempted to quantify the impact of capacity constraints. It was identified that capacity constraints may impact the marginal costs and benefits of an intervention and therefore its cost-effectiveness. When the static and dynamic value of implementation methods were adapted to allow for this varying… Advisors/Committee Members: NEWMAN, WILLIAM WG, DAKER-WHITE, GAVIN GJ, Payne, Katherine, Newman, William, Daker-White, Gavin.

Subjects/Keywords: Precision Medicine; Health Economics; Economic Evaluation; Capacity; Lung Cancer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wright, S. J. (2020). Accounting for Capacity Constraints in Economic Evaluations of Precision Medicine. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:326430

Chicago Manual of Style (16^th Edition):

Wright, Stuart James. “Accounting for Capacity Constraints in Economic Evaluations of Precision Medicine.” 2020. Doctoral Dissertation, University of Manchester. Accessed March 04, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:326430.

MLA Handbook (7^th Edition):

Wright, Stuart James. “Accounting for Capacity Constraints in Economic Evaluations of Precision Medicine.” 2020. Web. 04 Mar 2021.

Vancouver:

Wright SJ. Accounting for Capacity Constraints in Economic Evaluations of Precision Medicine. [Internet] [Doctoral dissertation]. University of Manchester; 2020. [cited 2021 Mar 04]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:326430.

Council of Science Editors:

Wright SJ. Accounting for Capacity Constraints in Economic Evaluations of Precision Medicine. [Doctoral Dissertation]. University of Manchester; 2020. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:326430

University of Manchester

22. Wright, Stuart. Accounting for capacity constraints in economic evaluations of precision medicine.

Degree: PhD, 2020, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/accounting-for-capacity-constraints-in-economic-evaluations-of-precision-medicine(6d330eca-695e-4563-875f-11ebe576cc15).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.820116

► Background: Precision medicine involves the use of tests, algorithms, or other information to target treatments to improve benefits or avoid harm for patients. Examples of… (more)

▼ Background: Precision medicine involves the use of tests, algorithms, or other information to target treatments to improve benefits or avoid harm for patients. Examples of precision medicine represent complex interventions and there are many barriers, or health system capacity constraints (hereafter "capacity constraints"), to their introduction into clinical practice. The assumptions underlying economic evaluations of healthcare interventions do not currently allow for the incorporation and measurement of the impact of capacity constraints. The overall aim of this PhD was to identify and quantify the impact of including capacity constraints in decision-analytic model-based cost-effectiveness analysis to better inform resource allocation decisions and the introduction of precision medicine into clinical practice. Methods: This thesis comprised six empirical chapters using different methods. A systematic review of systematic reviews (meta-review) was used to identify existing economic evaluations of precision medicine to determine if and how these studies quantified the impact of capacity constraints. Static and dynamic value of implementation methods were adapted to allow for the varying marginal costs and benefits which may arise due to health system capacity constraints and these methods were applied to a case study in breast cancer. To develop a typology of barriers to the introduction of examples of precision medicine, qualitative interviews were conducted with stakeholders in the implementation of examples of precision medicine in non-small cell lung cancer. A case study example of precision medicine was selected based on these interviews and a base case decision analytic model, replicating a published technology appraisal conducted by the National Institute for Health and Care Excellence (NICE), was created to evaluate the cost-effectiveness of immunohistochemistry (IHC) and fluorescent in-situ hybridisation (FISH) testing for anaplastic lymphoma kinase (ALK) alterations to guide treatment with crizotinib or docetaxel. Three capacity constraints were selected based on the qualitative interviews and these were incorporated into the base case model. The impact of these capacity constraints was quantified using static value of implementation methods. Hypothetical investments to reduce the impact of the capacity constraints were proposed and their potential value was determined using dynamic value of implementation methods. Results: The meta-review identified 45 previous reviews of economic evaluations of precision medicine from which a sample of 222 economic evaluations focusing on "test-treat" interventions were selected. Of these, 33 studies qualitatively discussed potential capacity constraints and nine studies attempted to quantify the impact of capacity constraints. It was identified that capacity constraints may impact the marginal costs and benefits of an intervention and therefore its cost-effectiveness. When the static and dynamic value of implementation methods were adapted to allow for this varying…

Subjects/Keywords: Capacity; Economic Evaluation; Lung Cancer; Precision Medicine; Health Economics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wright, S. (2020). Accounting for capacity constraints in economic evaluations of precision medicine. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/accounting-for-capacity-constraints-in-economic-evaluations-of-precision-medicine(6d330eca-695e-4563-875f-11ebe576cc15).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.820116

Chicago Manual of Style (16^th Edition):

Wright, Stuart. “Accounting for capacity constraints in economic evaluations of precision medicine.” 2020. Doctoral Dissertation, University of Manchester. Accessed March 04, 2021. https://www.research.manchester.ac.uk/portal/en/theses/accounting-for-capacity-constraints-in-economic-evaluations-of-precision-medicine(6d330eca-695e-4563-875f-11ebe576cc15).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.820116.

MLA Handbook (7^th Edition):

Wright, Stuart. “Accounting for capacity constraints in economic evaluations of precision medicine.” 2020. Web. 04 Mar 2021.

Vancouver:

Wright S. Accounting for capacity constraints in economic evaluations of precision medicine. [Internet] [Doctoral dissertation]. University of Manchester; 2020. [cited 2021 Mar 04]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/accounting-for-capacity-constraints-in-economic-evaluations-of-precision-medicine(6d330eca-695e-4563-875f-11ebe576cc15).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.820116.

Council of Science Editors:

Wright S. Accounting for capacity constraints in economic evaluations of precision medicine. [Doctoral Dissertation]. University of Manchester; 2020. Available from: https://www.research.manchester.ac.uk/portal/en/theses/accounting-for-capacity-constraints-in-economic-evaluations-of-precision-medicine(6d330eca-695e-4563-875f-11ebe576cc15).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.820116

University of South Florida

23. Latifi, Kujtim. Assessment of the Dependence of Ventilation Image Calculation from 4D-CT on Deformation and Ventilation Algorithms.

Degree: 2011, University of South Florida

URL: https://scholarcommons.usf.edu/etd/3197

► Ventilation imaging using 4D-CT is a convenient and cost effective functional imaging methodology which might be of value in radiotherapy treatment planning to spare functional… (more)

▼ Ventilation imaging using 4D-CT is a convenient and cost effective functional imaging methodology which might be of value in radiotherapy treatment planning to spare functional lung volumes. To calculate ventilation imaging from 4D-CT we must use deformable image registration (DIR). This study validates the DIR methods and investigates the dependence of calculated ventilation on DIR methods and ventilation algorithms. The first hypothesis is if ventilation algorithms are robust then they will be insensitive to the precise DIR used provided the DIR is accurate. The second hypothesis is that the change in Houndsfield Unit (HU) method is less dependent on the DIR used and depends more on the CT image quality due to the inherent noise of HUs in normal CT imaging. DIR of the normal end expiration and inspiration phases of the 4D-CT images was used to correlate the voxels between the two respiratory phases. All DIR algorithms were validated using a 4D pixel-based and point-validated breathing thorax model, consisting of a 4D-CT image data set along with associated landmarks. Three different DIR algorithms, Optical Flow (OF), Diffeomorphic Demons (DD) and Diffeomorphic Morphons (DM), were retrospectively applied to the same group of 10 esophagus and 10 lung cancer cases all of which had associated 4D-CT image sets that encompassed the entire lung volume. Three different ventilation calculation algorithms were compared (Jacobian, ΔV, and HU) using the Dice similarity coefficient comparison. In the validation of the DIR algorithms, the average target registration errors with one standard deviation for the DIR algorithms were 1.6 ± 0.7 mm, maximum 3.1 mm for OF, 1.3 ± 0.6 mm, maximum 3.3 mm for DM, 1.3 ± 0.6 mm, maximum 2.8 mm for DD, indicating registration errors were within 2 voxels. Dependence of ventilation images on the DIR was greater for the ΔV and the Jacobian methods than for the HU method. The Dice similarity coefficient for 20% of low ventilation volume for ΔV was 0.33 ± 0.03 between OF and DM, 0.44 ± 0.05 between OF and DD and 0.51 ± 0.04 between DM and DD. The similarity comparisons for Jacobian was 0.32 ± 0.03, 0.44 ± 0.05 and 0.51 ± 0.04 respectively, and for HU 0.53 ± 0.03, 0.56 ± 0.03 and 0.76 ± 0.04 respectively. Dependence of ventilation images on the ventilation method used showed good agreement between the ΔV and Jacobian methods but differences between these two and the HU method were significantly greater. Dice similarity coefficient for using OF as DIR was 0.86 ± 0.01 between ΔV and Jacobian, 0.28 ± 0.04 between ΔV and HU and 0.28 ± 0.04 between Jacobian and HU respectively. When using DM or DD as DIR, similar values were obtained when comparing the different ventilation calculation methods. The similarity values for 20% of the high ventilation volume were close to those found for the 20% low ventilation volume. Mean target registration error for all three DIR methods was within one voxel suggesting that the registration done by either of the methods is quite accurate. Ventilation calculation from…

Subjects/Keywords: Deformable Image Registration; Deformation; Lung Cancer; Lung Function; Radiotherapy; Ventilation Imaging; American Studies; Arts and Humanities; Medicine and Health Sciences; Physics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Latifi, K. (2011). Assessment of the Dependence of Ventilation Image Calculation from 4D-CT on Deformation and Ventilation Algorithms. (Thesis). University of South Florida. Retrieved from https://scholarcommons.usf.edu/etd/3197

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Latifi, Kujtim. “Assessment of the Dependence of Ventilation Image Calculation from 4D-CT on Deformation and Ventilation Algorithms.” 2011. Thesis, University of South Florida. Accessed March 04, 2021. https://scholarcommons.usf.edu/etd/3197.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Latifi, Kujtim. “Assessment of the Dependence of Ventilation Image Calculation from 4D-CT on Deformation and Ventilation Algorithms.” 2011. Web. 04 Mar 2021.

Vancouver:

Latifi K. Assessment of the Dependence of Ventilation Image Calculation from 4D-CT on Deformation and Ventilation Algorithms. [Internet] [Thesis]. University of South Florida; 2011. [cited 2021 Mar 04]. Available from: https://scholarcommons.usf.edu/etd/3197.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Latifi K. Assessment of the Dependence of Ventilation Image Calculation from 4D-CT on Deformation and Ventilation Algorithms. [Thesis]. University of South Florida; 2011. Available from: https://scholarcommons.usf.edu/etd/3197

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Loma Linda University

24. Siler, Shaunna. Clinicians’ Perspectives on Adopting a Lung Cancer Palliative Care Intervention.

Degree: PhD, Nursing, 2017, Loma Linda University

URL: https://scholarsrepository.llu.edu/etd/480

► Despite the significant progress in implementing palliative care interventions for cancer patients, few intervention studies seek healthcare clinicians’ input prior to implementation. The purpose… (more)

▼ Despite the significant progress in implementing palliative care interventions for cancer patients, few intervention studies seek healthcare clinicians’ input prior to implementation. The purpose of this research was then to explore palliative care and oncology clinicians’ (e.g., physicians, nurses, social workers, and chaplains) perspectives on current challenges and useful practices in meeting the quality of life needs of lung cancer patients and family caregivers, and to increase the likelihood of the adoption of a palliative care intervention based on understanding current trends in palliative care delivery at three outpatient oncology sites. The conceptual framework used for this study was the RE-AIM Model: Reach, efficacy, adoption, implementation, and maintenance of intervention research to successfully translate and sustain evidence-based practice. This was a multi-site qualitative study using focus group and key informant interviews with oncology and palliative care clinicians. Focus groups and individual phone interviews were conducted with 19 clinicians, who addressed useful practices and challenges in the following areas: (a) early palliative care; (b) interdisciplinary care planning; (c) symptom management; (d) addressing psychological and social needs; and (e) providing culturally respectful care, including spiritual care. In preparation for the intervention, specific education needs and organizational challenges were revealed through focus group and individual interviews with clinicians. These challenges included timing and staffing constraints, the need for clinician education on palliative care services to increase organizational buy-in and referrals, and support and education in providing spiritual support for patients and family caregivers. These findings highlight an important, often overlooked, step in the translation of palliative care intervention studies and may inform education and training in the areas of palliative care and spiritual care for lung cancer patients. Further, these findings pattern the adoption component of the Re-AIM Model for intervention studies in eliciting organizational support prior to implementation. Advisors/Committee Members: Mamier, Iris, Ferrell, Betty, Winslow, Betty W..

Subjects/Keywords: Medicine and Health Sciences; Nursing; Oncology; Palliative Care; Palliative treatment; Nursing; Lung Neoplasms; Oncology; Lung Cancer; Palliative Care; Oncology Clinicians

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Siler, S. (2017). Clinicians’ Perspectives on Adopting a Lung Cancer Palliative Care Intervention. (Doctoral Dissertation). Loma Linda University. Retrieved from https://scholarsrepository.llu.edu/etd/480

Chicago Manual of Style (16^th Edition):

Siler, Shaunna. “Clinicians’ Perspectives on Adopting a Lung Cancer Palliative Care Intervention.” 2017. Doctoral Dissertation, Loma Linda University. Accessed March 04, 2021. https://scholarsrepository.llu.edu/etd/480.

MLA Handbook (7^th Edition):

Siler, Shaunna. “Clinicians’ Perspectives on Adopting a Lung Cancer Palliative Care Intervention.” 2017. Web. 04 Mar 2021.

Vancouver:

Siler S. Clinicians’ Perspectives on Adopting a Lung Cancer Palliative Care Intervention. [Internet] [Doctoral dissertation]. Loma Linda University; 2017. [cited 2021 Mar 04]. Available from: https://scholarsrepository.llu.edu/etd/480.

Council of Science Editors:

Siler S. Clinicians’ Perspectives on Adopting a Lung Cancer Palliative Care Intervention. [Doctoral Dissertation]. Loma Linda University; 2017. Available from: https://scholarsrepository.llu.edu/etd/480

University of California – Berkeley

25. Dauphine, David. Arsenic in Drinking Water and Lung Disease in Chile, California and Nevada.

Degree: Environmental Health Sciences, 2015, University of California – Berkeley

URL: http://www.escholarship.org/uc/item/4j8025j6

► Millions of people are exposed to arsenic in drinking water. An ancient poison, arsenic occurs naturally in groundwater and geothermal springs. Removing arsenic from drinking… (more)

▼ Millions of people are exposed to arsenic in drinking water. An ancient poison, arsenic occurs naturally in groundwater and geothermal springs. Removing arsenic from drinking water costs about $200 million every year in the United States alone. The brunt of this is borne by California and other western states, where groundwater is needed more for drinking water. Arsenic in drinking water causes cardiovascular death, cognitive deficits in children, reproductive problems, and cancer. Surprisingly, many studies have shown that the human lung is especially susceptible to ingested arsenic. After being consumed in drinking water, arsenic accumulates in the lungs. Lung cancer is now believed to be the most common cause of death from this widespread contaminant. Most lung carcinogens, including tobacco smoke, asbestos, and silica, also cause non-malignant respiratory effects. Evidence suggests that arsenic in drinking water follows this pattern, but nearly all data involve adults with recent exposures. The impacts of early-life arsenic exposures on nonmalignant lung disease are largely unknown. In northern Chile, the city of Antofagasta (population 390,000 in 2014) had high concentrations of arsenic in drinking water (>800 µg/L) from 1958 until 1970, when a new treatment plant was installed. This scenario, with its large population, distinct period of high exposure, and accurate data on past exposure, is virtually unprecedented in environmental epidemiology. Chapter 2 of this dissertation describes a pilot study on early-life arsenic exposure and long-term lung function. We recruited a convenience sample consisting primarily of nursing school employees in Antofagasta and Arica (population 160,000) a city with low drinking water arsenic. Lung function and respiratory symptoms in 32 adults exposed to >800 µg/L arsenic before age 10 were compared to 65 adults without high early-life exposure. Early-life arsenic exposure was associated with 11.5% lower forced expiratory volume in one second (FEV1) (p = 0.04), 12.2% lower forced vital capacity (FVC) (p = 0.04), and increased breathlessness (prevalence odds ratio = 5.94, 95% confidence interval 1.36–26.02). Exposure-response relationships between early-life arsenic concentration and adult FEV1 and FVC were also identified (p trend = 0.03). These results suggest that early-life exposure to arsenic in drinking water may have irreversible respiratory effects of a magnitude similar to smoking throughout adulthood. Given the small study size and non-random recruitment methods, further research is needed to confirm these findings.The arsenic concentrations >800 µg/L in Chile can reveal previously unknown health outcomes, but they do not shed much light on what the drinking water standard should be. Arsenic is known to cause lung cancer at concentrations above about 200 µg/L. The effects of lower exposures are unknown. This uncertainty has created controversy over the 10 µg/L World Health Organization guideline and U.S. regulatory limit for public water supplies because arsenic is…

Subjects/Keywords: Health sciences; Environmental science; Aquatic sciences; Arsenic; Cancer; Drinking Water; Environmental Epidemiology; Health; Lung

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dauphine, D. (2015). Arsenic in Drinking Water and Lung Disease in Chile, California and Nevada. (Thesis). University of California – Berkeley. Retrieved from http://www.escholarship.org/uc/item/4j8025j6

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dauphine, David. “Arsenic in Drinking Water and Lung Disease in Chile, California and Nevada.” 2015. Thesis, University of California – Berkeley. Accessed March 04, 2021. http://www.escholarship.org/uc/item/4j8025j6.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dauphine, David. “Arsenic in Drinking Water and Lung Disease in Chile, California and Nevada.” 2015. Web. 04 Mar 2021.

Vancouver:

Dauphine D. Arsenic in Drinking Water and Lung Disease in Chile, California and Nevada. [Internet] [Thesis]. University of California – Berkeley; 2015. [cited 2021 Mar 04]. Available from: http://www.escholarship.org/uc/item/4j8025j6.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dauphine D. Arsenic in Drinking Water and Lung Disease in Chile, California and Nevada. [Thesis]. University of California – Berkeley; 2015. Available from: http://www.escholarship.org/uc/item/4j8025j6

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas Medical Center

26. Pu, Xia. Genetic Predictors of Clinical Outcomes in Non-Small Cell Lung Cancer Patients.

Degree: PhD, 2012, Texas Medical Center

URL: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/264

► Lung cancer is the leading cause of cancer-related mortality in the US. Emerging evidence has shown that host genetic factors can interact with environmental… (more)

▼ Lung cancer is the leading cause of cancer-related mortality in the US. Emerging evidence has shown that host genetic factors can interact with environmental exposures to influence patient susceptibility to the diseases as well as clinical outcomes, such as survival and recurrence. We aimed to identify genetic prognostic markers for non-small cell lung cancer (NSCLC), a major (85%) subtype of lung cancer, and also in other subgroups. With the fast evolution of genotyping technology, genetic association studies have went through candidate gene approach, to pathway-based approach, to the genome wide association study (GWAS). Even in the era of GWAS, pathway-based approach has its own advantages on studying cancer clinical outcomes: it is cost-effective, requiring a smaller sample size than GWAS easier to identify a validation population and explore gene-gene interactions. In the current study, we adopted pathway-based approach focusing on two critical pathways - miRNA and inflammation pathways. MicroRNAs (miRNA) post-transcriptionally regulate around 30% of human genes. Polymorphisms within miRNA processing pathways and binding sites may influence patients’ prognosis through altered gene regulation. Inflammation plays an important role in cancer initiation and progression, and also has shown to impact patients’ clinical outcomes. We first evaluated 240 single nucleotide polymorphisms (SNPs) in miRNA biogenesis genes and predicted binding sites in NSCLC patients to determine associations with clinical outcomes in early-stage (stage I and II) and late-stage (stage III and IV) lung cancer patients, respectively. First, in 535 early-stage patients, after correcting multiple comparisons, FZD4:rs713065 (hazard ratio [HR]:0.46, 95% confidence interval [CI]:0.32-0.65) showed a significant inverse association with survival in early stage surgery-only patients. SP1:rs17695156 (HR:2.22, 95% CI:1.44-3.41) and DROSHA:rs6886834 (HR:6.38, 95% CI:2.49-16.31) conferred increased risk of progression in the all patients and surgery-only populations, respectively. FAS:rs2234978 was significantly associated with improved survival in all patients (HR:0.59, 95% CI:0.44-0.77) and in the surgery plus chemotherapy populations (HR:0.19, 95% CI:0.07-0.46).. Functional genomics analysis demonstrated that this variant creates a miR-651 binding site resulting in altered miRNA regulation of FAS, providing biological plausibility for the observed association. We then analyzed these associations in 598 late-stage patients. After multiple comparison corrections, no SNPs remained significant in the late stage group, while the top SNP NAT1:rs15561 (HR=1.98, 96%CI=1.32-2.94) conferred a significantly increased risk of death in the chemotherapy subgroup. To test the hypothesis that genetic variants in the inflammation-related pathways may be associated with survival in NSCLC patients, we first conducted a three-stage study. In the discovery phase, we investigated a comprehensive panel of… Advisors/Committee Members: Xifeng Wu, Craig L. Hanis, Gary E. Gallick.

Subjects/Keywords: Lung Cancer; clinical outcomes; polymorphism; Epidemiology; Medicine and Health Sciences; Public Health

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APA (6^th Edition):

Pu, X. (2012). Genetic Predictors of Clinical Outcomes in Non-Small Cell Lung Cancer Patients. (Doctoral Dissertation). Texas Medical Center. Retrieved from https://digitalcommons.library.tmc.edu/utgsbs_dissertations/264

Chicago Manual of Style (16^th Edition):

Pu, Xia. “Genetic Predictors of Clinical Outcomes in Non-Small Cell Lung Cancer Patients.” 2012. Doctoral Dissertation, Texas Medical Center. Accessed March 04, 2021. https://digitalcommons.library.tmc.edu/utgsbs_dissertations/264.

MLA Handbook (7^th Edition):

Pu, Xia. “Genetic Predictors of Clinical Outcomes in Non-Small Cell Lung Cancer Patients.” 2012. Web. 04 Mar 2021.

Vancouver:

Pu X. Genetic Predictors of Clinical Outcomes in Non-Small Cell Lung Cancer Patients. [Internet] [Doctoral dissertation]. Texas Medical Center; 2012. [cited 2021 Mar 04]. Available from: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/264.

Council of Science Editors:

Pu X. Genetic Predictors of Clinical Outcomes in Non-Small Cell Lung Cancer Patients. [Doctoral Dissertation]. Texas Medical Center; 2012. Available from: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/264

University of Texas Southwestern Medical Center

27. Ma, Tsung-wei. Two Psychological Survey Studies: (1) Understanding the Stigma Toward Lung Cancer and (2) Using Research Domain Criteria Project (RDoC) to Predict Remission Rates of Major Depressive Disorder Patients.

Degree: 2017, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/7741

► This dissertation is composed of two psychological survey studies. In the first study, people's negative attitudes toward lung cancer are assessed and discussed. The second… (more)

Subjects/Keywords: Attitude of Health Personnel; Health Personnel; Lung Neoplasms; Mental Disorders; Psychiatry; Research; Social Stigma

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APA (6^th Edition):

Ma, T. (2017). Two Psychological Survey Studies: (1) Understanding the Stigma Toward Lung Cancer and (2) Using Research Domain Criteria Project (RDoC) to Predict Remission Rates of Major Depressive Disorder Patients. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/7741

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ma, Tsung-wei. “Two Psychological Survey Studies: (1) Understanding the Stigma Toward Lung Cancer and (2) Using Research Domain Criteria Project (RDoC) to Predict Remission Rates of Major Depressive Disorder Patients.” 2017. Thesis, University of Texas Southwestern Medical Center. Accessed March 04, 2021. http://hdl.handle.net/2152.5/7741.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ma, Tsung-wei. “Two Psychological Survey Studies: (1) Understanding the Stigma Toward Lung Cancer and (2) Using Research Domain Criteria Project (RDoC) to Predict Remission Rates of Major Depressive Disorder Patients.” 2017. Web. 04 Mar 2021.

Vancouver:

Ma T. Two Psychological Survey Studies: (1) Understanding the Stigma Toward Lung Cancer and (2) Using Research Domain Criteria Project (RDoC) to Predict Remission Rates of Major Depressive Disorder Patients. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2017. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/2152.5/7741.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ma T. Two Psychological Survey Studies: (1) Understanding the Stigma Toward Lung Cancer and (2) Using Research Domain Criteria Project (RDoC) to Predict Remission Rates of Major Depressive Disorder Patients. [Thesis]. University of Texas Southwestern Medical Center; 2017. Available from: http://hdl.handle.net/2152.5/7741

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Washington

28. Mani, Deepthi. Mortality benefit from LDCT lung cancer screening.

Degree: 2017, University of Washington

URL: http://hdl.handle.net/1773/40592

► Introduction: The estimated mortality benefit to current and former smokers of cigarettes from annual lung cancer screening with low dose helical computed tomography (LDCT) is… (more)

Subjects/Keywords: LDCT; Lung cancer screening; Screening Mortality benefit; Public health; Medicine; Health services

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APA (6^th Edition):

Mani, D. (2017). Mortality benefit from LDCT lung cancer screening. (Thesis). University of Washington. Retrieved from http://hdl.handle.net/1773/40592

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mani, Deepthi. “Mortality benefit from LDCT lung cancer screening.” 2017. Thesis, University of Washington. Accessed March 04, 2021. http://hdl.handle.net/1773/40592.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mani, Deepthi. “Mortality benefit from LDCT lung cancer screening.” 2017. Web. 04 Mar 2021.

Vancouver:

Mani D. Mortality benefit from LDCT lung cancer screening. [Internet] [Thesis]. University of Washington; 2017. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1773/40592.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mani D. Mortality benefit from LDCT lung cancer screening. [Thesis]. University of Washington; 2017. Available from: http://hdl.handle.net/1773/40592

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Washington

29. Gowda, Shilpa. Ambient Air Pollution and Lung Cancer Risk in the Women's Health Initiative Observational Study.

Degree: 2016, University of Washington

URL: http://hdl.handle.net/1773/36449

► Background: Outdoor air pollution was recently classified as a human carcinogen by the International Agency for Research on Cancer. However, epidemiologic studies supporting this classification… (more)

▼ Background: Outdoor air pollution was recently classified as a human carcinogen by the International Agency for Research on Cancer. However, epidemiologic studies supporting this classification have focused on lung cancer mortality rather than incidence, and most previous studies have included relatively few women. Women in older age groups with higher incidence of lung cancer have been particularly underrepresented. New studies that address these limitations are needed to further explore and quantify the strength of the association between ambient air pollution and lung cancer. Methods: We sought to evaluate this association, using data from the observational arm of the Women’s Health Initiative (WHI) study, a large, U.S.-based cohort of post-menopausal women (final sample size after applying exclusions = 86,146, with 1,332 lung cancer cases). Mean follow-up time of participants was 11 years, with a maximum follow-up time of 15 years. We used previously validated state-of-the-art geospatial models to estimate exposures to fine particulate matter (PM2.5) and nitrogen dioxide (NO2), two major constituents of ambient air pollution, based on participants’ residential addresses. NO2 is considered a proxy measure for traffic- related air pollutants. We also characterized participants’ exposures to traffic-related air pollution by the distances of their residential addresses to a primary limited-access highway. Using Cox proportional hazards regression models, we calculated hazard ratios (HRs) for the risk of lung cancer in association with these exposure metrics. We adjusted for several potential confounders, including age, race, body mass index, region of residence (including urbanicity), smoking habits, and socioeconomic status. Furthermore, we conducted exploratory analyses restricted to never smokers, adjusting for second-hand smoke exposures. Separate exploratory analyses stratified lung cancer outcomes by major histological subtypes. Results: In our primary analyses, no significant associations were observed. For example, when comparing the highest quartile of PM2.5 exposure (>14.59 µg/m3) to the lowest quartile (≤10.58 µg/m3), a HR of 0.91 [95% Confidence Interval (CI): 0.61-1.34] was observed. There were no consistent relationships seen between distance to roadway and lung cancer. There were also no significant associations observed in our exploratory analyses. Conclusions: Overall, we did not observe an association between ambient air pollution and lung cancer risk. However, despite the large sample size, our results do not exclude effect sizes seen in some previous studies. Additional years of follow-up and inclusion of participants from the WHI clinical trial arm would enhance study power and may make results more informative. Advisors/Committee Members: Kaufman, Joel (advisor), Bhatti, Parveen (advisor).

Subjects/Keywords: air pollution; cancer; environmental health; environmental medicine; lung cancer; particulate matter; Public health; Environmental health; Environmental health

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gowda, S. (2016). Ambient Air Pollution and Lung Cancer Risk in the Women's Health Initiative Observational Study. (Thesis). University of Washington. Retrieved from http://hdl.handle.net/1773/36449

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gowda, Shilpa. “Ambient Air Pollution and Lung Cancer Risk in the Women's Health Initiative Observational Study.” 2016. Thesis, University of Washington. Accessed March 04, 2021. http://hdl.handle.net/1773/36449.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gowda, Shilpa. “Ambient Air Pollution and Lung Cancer Risk in the Women's Health Initiative Observational Study.” 2016. Web. 04 Mar 2021.

Vancouver:

Gowda S. Ambient Air Pollution and Lung Cancer Risk in the Women's Health Initiative Observational Study. [Internet] [Thesis]. University of Washington; 2016. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1773/36449.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gowda S. Ambient Air Pollution and Lung Cancer Risk in the Women's Health Initiative Observational Study. [Thesis]. University of Washington; 2016. Available from: http://hdl.handle.net/1773/36449

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

30. Watkins, W. Tyler. Optimization of Radiation Therapy in Time-Dependent Anatomy.

Degree: PhD, Medical Physics, 2013, Virginia Commonwealth University

URL: https://doi.org/10.25772/1JM1-3604 ; https://scholarscompass.vcu.edu/etd/3069

► The objective of this dissertation is to develop treatment planning techniques that have the potential to improve radiation therapy of time-dependent (4D) anatomy. Specifically, this… (more)

▼ The objective of this dissertation is to develop treatment planning techniques that have the potential to improve radiation therapy of time-dependent (4D) anatomy. Specifically, this study examines dose estimation, dose evaluation, and decision making in the context of optimizing lung cancer radiation therapy. Two methods of dose estimation are compared in patients with locally advanced and early stage lung cancer: dose computed on a single image (3D-dose) and deformably registered, accumulated dose (or 4D-dose). The results indicate that differences between 3D- and 4D- dose are not significant in organs at risk (OARs), however, 4D-dose to a moving lung cancer target can deviate from 3D-dose. These differences imply that optimization of the 4D-dose through multiple-anatomy optimization (MAO) can improve radiation therapy in 4D-anatomy. MAO incorporates time-dependent target and OAR geometry while enabling a simple, clinically realizable delivery. MAO has the potential to enhance the therapeutic ratio in terms of target coverage and OAR sparing in 4D-anatomy. In dose evaluation within 4D-anatomy; dose-to-mass is a more intuitive and precise metric in estimating the effects of radiation in tissues. Assuming physical density is proportional to functional tissue density, dose-to-mass has a 1-1 correspondence with radiation damage. Dose-to-mass optimization boosts dose in massive regions of lung cancer targets and can reduce integral dose to lung by preferentially treating through regions of low-density lung tissue. Finally, multi-criteria optimization (MCO) is implemented in order to clarify decision making during plan design for lung cancer treatment. An MCO basis set establishes a patient-specific decision space which reveals trade-offs in OAR-dose at a fixed, constrained target dose. By interpolating the MCO basis set and evaluating the plan on 4D-anatomy, patient- and organ- specific conservatism in plan design can be expressed in real time. Through improved methods of dose estimation, dose evaluation, and decision making, this dissertation will positively impact radiation therapy of time-dependent anatomy. Advisors/Committee Members: Jeffrey V. Siebers.

Subjects/Keywords: Radiation Therapy; treatment planning; lung cancer; optimization; Health and Medical Physics; Medicine and Health Sciences; Public Health

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Watkins, W. T. (2013). Optimization of Radiation Therapy in Time-Dependent Anatomy. (Doctoral Dissertation). Virginia Commonwealth University. Retrieved from https://doi.org/10.25772/1JM1-3604 ; https://scholarscompass.vcu.edu/etd/3069

Chicago Manual of Style (16^th Edition):

Watkins, W Tyler. “Optimization of Radiation Therapy in Time-Dependent Anatomy.” 2013. Doctoral Dissertation, Virginia Commonwealth University. Accessed March 04, 2021. https://doi.org/10.25772/1JM1-3604 ; https://scholarscompass.vcu.edu/etd/3069.

MLA Handbook (7^th Edition):

Watkins, W Tyler. “Optimization of Radiation Therapy in Time-Dependent Anatomy.” 2013. Web. 04 Mar 2021.

Vancouver:

Watkins WT. Optimization of Radiation Therapy in Time-Dependent Anatomy. [Internet] [Doctoral dissertation]. Virginia Commonwealth University; 2013. [cited 2021 Mar 04]. Available from: https://doi.org/10.25772/1JM1-3604 ; https://scholarscompass.vcu.edu/etd/3069.

Council of Science Editors:

Watkins WT. Optimization of Radiation Therapy in Time-Dependent Anatomy. [Doctoral Dissertation]. Virginia Commonwealth University; 2013. Available from: https://doi.org/10.25772/1JM1-3604 ; https://scholarscompass.vcu.edu/etd/3069

Open Access Theses and Dissertations