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Erasmus University Rotterdam

1. Lambregts, Suzanne. Long-term Outcome in Children and Youth with Acquired Brain Injury.

Degree: Department of Rehabilitation Medicine, 2019, Erasmus University Rotterdam

textabstractThis thesis focused on long-term neurological outcome, participation, health-related quality of life, family impact and their predictors in children and youth with acquired brain injury.

Subjects/Keywords: Niet-aangeboren hersenletsel; lange termijn gevolgen; neurologische stoornissen; participatie; kwaliteit van leven; impact gezin; kinderen en adolescenten; voorspellers

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Lambregts, S. (2019). Long-term Outcome in Children and Youth with Acquired Brain Injury. (Doctoral Dissertation). Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/122598

Chicago Manual of Style (16th Edition):

Lambregts, Suzanne. “Long-term Outcome in Children and Youth with Acquired Brain Injury.” 2019. Doctoral Dissertation, Erasmus University Rotterdam. Accessed December 04, 2020. http://hdl.handle.net/1765/122598.

MLA Handbook (7th Edition):

Lambregts, Suzanne. “Long-term Outcome in Children and Youth with Acquired Brain Injury.” 2019. Web. 04 Dec 2020.

Vancouver:

Lambregts S. Long-term Outcome in Children and Youth with Acquired Brain Injury. [Internet] [Doctoral dissertation]. Erasmus University Rotterdam; 2019. [cited 2020 Dec 04]. Available from: http://hdl.handle.net/1765/122598.

Council of Science Editors:

Lambregts S. Long-term Outcome in Children and Youth with Acquired Brain Injury. [Doctoral Dissertation]. Erasmus University Rotterdam; 2019. Available from: http://hdl.handle.net/1765/122598

2. Zellem, Lennart. For better or worse? Long-term outcome of critical illness in childhood: Long-term outcome of critical illness in childhood.

Degree: 2015, Erasmus University Medical Center

markdownabstract__Abstract__ The aim of this thesis was to investigate the long-term outcome of critically ill children admitted to the pediatric intensive care unit (PICU) of the Erasmus MC – Sophia Children’s’ Hospital in Rotterdam, the Netherlands. Our main focus was to investigate the long-term health status, health-related quality of life (HR-QoL), emotional and behavioral functioning, and neuropsychological functioning in survivors of cardiac arrest (CA) in childhood. This included a semi-structured interview, physical and neuropsychological examination, and the use of validated, internationally well-known questionnaires with a multi-informant approach. Further, the influence of medical predictor variables, such as the impact of hyperoxia on mortality after CA, and analgesia-sedation on the long-term neuropsychological outcome after a critical illness (specifically meningococcal septic shock) was examined. In the study described in chapter 2 we analyzed the relationship between the partial pressure of arterial oxygen (PaO2) and in-hospital (IH) mortality in children after CA. We compared the conventional cut-off analysis, with the cumulative analysis, a new method in PaO2 analysis. The innovative aspect of this study is that it uses a novel and simple method (area under the curve) to analyze this cumulative PaO2. We found that patients with mild therapeutic hypothermia (MTH) and higher cumulative PaO2 had a lower mortality rate. With the cumulative PaO2 measurement, we could not reproduce the relationship between higher PaO2 and IH-mortality in children after CA as found in various cut-off studies. In chapter 3 we provided a detailed overview of the long-term health status and health-related quality of life (HR-QoL) in survivors of CA in childhood and their parents. After the initial survival another 9% died following PICU discharge. A minority of CA survivors showed long-term neurological impairments, chronic symptoms, and renal impairments. On health status and HR-QoL, parent-reports of CA survivors showed significantly worse outcomes on physical scales and parental impact compared to normative data. On self-reports no significant differences with normative data were found. Surprisingly, parents reported better scores towards their own functioning. Patients’ health status, general health perceptions and physical summary scores were significantly associated with CA-related pre-existing condition. In chapter 4 the results of the long-term emotional and behavioral functioning of CA survivors are presented. Compared to normative data, CA survivors showed significantly more long-term attention problems and somatic complaints, on parents’ and teachers’ reports. On self-reports, significantly less social problems were found. According to parents, children showed more often psychopathological problem behavior. Remarkably, less social problems (self-reports) and no higher levels on anxiety, depression or posttraumatic stress problems were found. Boys, older children, and basic life support were…

Subjects/Keywords: Long-term outcome; Cardiac arrest; Children; Meningococcal septic shock; PICU; Cumulative oxygen; reanimatie; kinderen; lange-termijn gevolgen

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Zellem, L. (2015). For better or worse? Long-term outcome of critical illness in childhood: Long-term outcome of critical illness in childhood. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/78304

Chicago Manual of Style (16th Edition):

Zellem, Lennart. “For better or worse? Long-term outcome of critical illness in childhood: Long-term outcome of critical illness in childhood.” 2015. Doctoral Dissertation, Erasmus University Medical Center. Accessed December 04, 2020. http://hdl.handle.net/1765/78304.

MLA Handbook (7th Edition):

Zellem, Lennart. “For better or worse? Long-term outcome of critical illness in childhood: Long-term outcome of critical illness in childhood.” 2015. Web. 04 Dec 2020.

Vancouver:

Zellem L. For better or worse? Long-term outcome of critical illness in childhood: Long-term outcome of critical illness in childhood. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2015. [cited 2020 Dec 04]. Available from: http://hdl.handle.net/1765/78304.

Council of Science Editors:

Zellem L. For better or worse? Long-term outcome of critical illness in childhood: Long-term outcome of critical illness in childhood. [Doctoral Dissertation]. Erasmus University Medical Center; 2015. Available from: http://hdl.handle.net/1765/78304

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