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You searched for subject:(labirinto de Barnes). Showing records 1 – 3 of 3 total matches.

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Universidade Federal de Santa Maria

1. Mauren Assis de Souza. O envolvimento de proteínas quinases na facilitação do aprendizado espacial induzido por creatina.

Degree: 2009, Universidade Federal de Santa Maria

O declínio cognitivo associado a doenças neurodegenerativas é um sintoma cada vez mais comum encontrado em pacientes, provavelmente devido ao aumento da expectativa de vida da população. Dada a escassez de medidas terapêuticas efetivas para o déficit de memória apresentado por pacientes, evidencia-se a importância da busca de novos compostos e do estudo de seus mecanismos de ação. Nesse contexto, recentes estudos mostraram a eficácia de algumas substâncias com ação neuroprotetora, como a creatina (Cr), na terapia de pacientes com déficit de memória e em modelos experimentais. A Cr é um composto guanidínico sintetizado endogenamente nos rins, fígado, pâncreas e cérebro, que apresenta ação neuroprotetora e neuromoduladora no sistema nervoso central. Estudos mostram que a administração de compostos guanidínicos, como a Cr, podem estar relacionados com a melhora da memória devido à interação com o sítio das poliaminas no receptor N-metil-D-Aspartato (NMDA) e por atuar como tampão energético intracelular. Neste contexto, o objetivo deste estudo foi investigar o envolvimento do transportador de Cr (CreaT), das proteínas quinases dependente de AMPc (PKA) e dependente de Ca2+/calmodulina II (CaMKII) na melhora do aprendizado espacial induzido por Cr no hipocampo de ratos. Após o treino no labirinto de Barnes, os ratos foram injetados no hipocampo, bilateralmente, com Cr e/ou 3-ácido guanidinico propiônico (3-GPA, um inibidor do transportador de creatina); Cr e/ou [N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide, Di-HCl Salt] (H-89, um inibidor da PKA); Cr e/ou 1,8-Naphthoylene benzimidazole-3- carboxylic acid (STO-609, um inibidor da CaMKII). A administração de 3-GPA, H-89 e STO-609 diminuiu o efeito facilitatório da Cr na memória espacial de ratos, observado no teste do labirinto de Barnes. De acordo com esses resultados, decidimos investigar o envolvimento da ativação do elemento de ligação responsivo ao AMPc (pCREB), PKA (pPKA) e CaMKII (pCaMKII) após a administração de Cr no hipocampo de animais treinados no labirinto de Barnes. Trinta minutos após a injeção de Cr, foi observado um aumento nos níveis de pCREB e pCaMKII, mas não nos níveis de pPKA no hipocampo de ratos. Estes achados sugerem que a facilitação do aprendizado espacial induzido pela Cr depende do seu transporte para o meio intracelular, assim como, envolve a via de sinalização celular da CaMKII/CREB no hipocampo de ratos.

Decline cognitive related to neurodegenerative diseases are very commom in patients, probably in function of aging. Since there are few effectives therapeutics approaches to loss memory treatment, but studies about new therapeutics approaches are necessary regarding neuroprotective drugs. Thus, recent works have been showing the efficacy of some neuroprotective compounds like creatine (Cr) in treatment of patients and experimental models with memory defcit. Creatine is a guanidine compound synthesized from glycine, arginine and S-adenosylmethionine in the kidneys, liver and brain that have been presented neuroprotective and…

Advisors/Committee Members: Cristina Wayne Nogueira, Michele Rechia Fighera, Maribel Antonello Rubin.

Subjects/Keywords: protein kinase; creatine; proteínas quinases; creatina; labirinto de Barnes; memória espacial; FARMACIA; spatial learning; Barnes maze

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Souza, M. A. d. (2009). O envolvimento de proteínas quinases na facilitação do aprendizado espacial induzido por creatina. (Thesis). Universidade Federal de Santa Maria. Retrieved from http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=2890

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Souza, Mauren Assis de. “O envolvimento de proteínas quinases na facilitação do aprendizado espacial induzido por creatina.” 2009. Thesis, Universidade Federal de Santa Maria. Accessed June 16, 2019. http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=2890.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Souza, Mauren Assis de. “O envolvimento de proteínas quinases na facilitação do aprendizado espacial induzido por creatina.” 2009. Web. 16 Jun 2019.

Vancouver:

Souza MAd. O envolvimento de proteínas quinases na facilitação do aprendizado espacial induzido por creatina. [Internet] [Thesis]. Universidade Federal de Santa Maria; 2009. [cited 2019 Jun 16]. Available from: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=2890.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Souza MAd. O envolvimento de proteínas quinases na facilitação do aprendizado espacial induzido por creatina. [Thesis]. Universidade Federal de Santa Maria; 2009. Available from: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=2890

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Universidade do Rio Grande do Norte

2. Macêdo, Priscila Tavares. Investigação dos sintomas iniciais da doença de alzheimer em ratos wistar submetidos à infusão intracerebral de peptídeos amilóides e do potencial neuroprotetor do extrato de erythrina velutina por meio do labirinto de barnes .

Degree: 2018, Universidade do Rio Grande do Norte

Alzheimer’s disease (AD) is present in 46.8 million people in the world, and is characterized by the progressive decline of cognition, mainly episodic memory. AD is multifactorial, and the accumulation of amyloid peptides (Aβ) is the main proposed mechanism underlying neurodegeneration. Aβ are the main components of the amyloid plaques in the brain, that are physiopathological hallmarks of the disease. Intracerebral infusion of Aβ in rats is usually used as an animal model of DA and generates the accumulation of these peptides in the brain together with spatial memory impairment. However, most studies show moderate to severe deficits after chronic Aβ infusion, without evaluation of possible subtle initial deficits. The study of the initial stages of AD is relevant for mechanicistic and therapeutic investigations. The Barnes maze has been used for investigating deficits in the hippocampal function in rats. The animals are exposed to a circular apparatus with holes in its periphery. One of the holes is connected to a safe place. In this task, rats navigate guided by distal cues to find this safe compartment. The evaluation is conduct by parameters of general performance (latency and distance to reach target, number of errors, among others) and by a specific analysis of search strategies. In this way, the animal use spatial information and move directly towards the target (direct strategy), visit sequential holes until reach the target (serial strategy) or visit holes in a non-systematic fashion until reach the target (aleatory search). The analysis of strategies allows the detection of alterations in the mode of solution of the task. In the present study, we aimed to investigate initial cognitive signs of AD in Wistar rats submitted to intracerebral infusions of Aβ, as well as the effects of a potentially neuroprotective treatment, by the evaluation of spatial memory in the Barnes maze. We used the alkaloid extract of Erythrina velutina (“mulungu”), which was previously studied for anxiolytic, anti-inflammatory, antioxidant and cholinergic actions. First, we standardized the task to our experimental conditions, and verified a possible influence of repeated expositions to the apparatus (for future long-term protocols) or of the implantation of the cannulas in the brain. Rats went through (or not) to implantation of cannulas (bilaterally in the hippocampal CA1 and in the lateral ventricle) and were exposed to 5 sequences of exposition to the Barnes maze (4 trainning sessions with 4 trials each, a 24h test and a 10-day retest sessions). Both groups showed task retrieval, and there was a slightly improved performance in the implanted group. We concluded that the task can be held repeatedly, and in implanted animals, without altering the performance. In the second phase, we investigated the use of different strategies in the Barnes maze by rats submitted to the presence of absence of distal cues. Rats were exposed to the training phase, and in the probe session (24 h later) half the animals… Advisors/Committee Members: Silva, Regina Helena da (advisor), 18747270829 (advisor), Costa, Marcos Romualdo (advisor), 05278916737 (advisor).

Subjects/Keywords: Alzheimer; Peptídeos beta-amilóides; Memória espacial; Preferência de estratégia; Labirinto de Barnes; Erythrina velutina (mulungu)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Macêdo, P. T. (2018). Investigação dos sintomas iniciais da doença de alzheimer em ratos wistar submetidos à infusão intracerebral de peptídeos amilóides e do potencial neuroprotetor do extrato de erythrina velutina por meio do labirinto de barnes . (Doctoral Dissertation). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/25471

Chicago Manual of Style (16th Edition):

Macêdo, Priscila Tavares. “Investigação dos sintomas iniciais da doença de alzheimer em ratos wistar submetidos à infusão intracerebral de peptídeos amilóides e do potencial neuroprotetor do extrato de erythrina velutina por meio do labirinto de barnes .” 2018. Doctoral Dissertation, Universidade do Rio Grande do Norte. Accessed June 16, 2019. http://repositorio.ufrn.br/handle/123456789/25471.

MLA Handbook (7th Edition):

Macêdo, Priscila Tavares. “Investigação dos sintomas iniciais da doença de alzheimer em ratos wistar submetidos à infusão intracerebral de peptídeos amilóides e do potencial neuroprotetor do extrato de erythrina velutina por meio do labirinto de barnes .” 2018. Web. 16 Jun 2019.

Vancouver:

Macêdo PT. Investigação dos sintomas iniciais da doença de alzheimer em ratos wistar submetidos à infusão intracerebral de peptídeos amilóides e do potencial neuroprotetor do extrato de erythrina velutina por meio do labirinto de barnes . [Internet] [Doctoral dissertation]. Universidade do Rio Grande do Norte; 2018. [cited 2019 Jun 16]. Available from: http://repositorio.ufrn.br/handle/123456789/25471.

Council of Science Editors:

Macêdo PT. Investigação dos sintomas iniciais da doença de alzheimer em ratos wistar submetidos à infusão intracerebral de peptídeos amilóides e do potencial neuroprotetor do extrato de erythrina velutina por meio do labirinto de barnes . [Doctoral Dissertation]. Universidade do Rio Grande do Norte; 2018. Available from: http://repositorio.ufrn.br/handle/123456789/25471


Universidade Federal de Santa Maria

3. Frederico Diniz Lima. O papel da enzima Na+,K+-ATPase no déficit cognitivo e no efeito profilático induzido pelo exercício físico após o Traumatismo Crânio-Encefálico.

Degree: 2009, Universidade Federal de Santa Maria

Traumatic Brain Injury (TBI) is the major cause of death or cognitive deficits in industrialized countries. Although studies have indicate that the oxidative stress and functional deficits after TBI are connected events, the mechanisms that outline the development of these cognitive deficits are, still, limited. In this context, we investigated the involvement of oxidative stress markers (thiobarbituric acid reactive species; TBARS and protein carbonylation) and the Na+,K+-ATPase enzyme activity on the spatial learning after one and three months from a fluid percussion injury (FPI) in rats. The results revealed that FPI increase the latency of escape and the number of the errors on the Barnes Maze Test one and three months after FPI. We also found an increase of TBARS and protein carbonylation in parietal cortex after one and three months FPI. In addition, statistical analysis revealed a decrease of the Na+,K+- ATPase enzyme activity in the parietal cortex after FPI (time-dependent). These results suggest that cognitive impairment following FPI may result, at least in part, from increase of two oxidative stress markers, protein carbonylation and TBARS that occurs concomitantly to a decrease in Na+,K+-ATPase activity. Physical exercise, despite the involvement on the generation of the reactive oxygen species (ROS), is used on the rehabilitation of TBI. However, although the favorable effects of physical exercise on traumatic brain injury (TBI) patients is well known, the specific mechanisms involved in this protection after TBI has been limited. Thus, we investigated whether physical training protects against oxidative damage (measured by protein carbonylation and TBARS) and neurochemical alterations represented by immunodetection of alpha subunit and activity of Na+,K+-ATPase after FPI in cerebral cortex of rats. The results revealed that physical training protected against oxidative damage induced by FPI. In addition, physical training was effective against Na+,K+- ATPase enzyme activity inhibition and α subunit level decrease after FPI. The Pearson correlation showed that the decrease of the catalytical levels of the Na+,K+- ATPase enzyme α subunit is related with the increasing on oxidative stress markers. Moreover, the physical activity-related protection against free radicals induced by FPI links with maintenance of α subunit immunocontent. These results suggest that the effective protection stimulated by physical exercise on the neuronal damage induced by TBI has connection with the protection of the specific targets from the free radicals action, like Na+,K+-ATPase enzyme.

O Traumatismo crânio-encefálico (TCE) é uma das maiores causas de morte ou déficits cognitivos nos países industrializados. Apesar de os estudos indicarem que o estresse oxidativo e os déficits funcionais que ocorrem após TCE serem eventos interrelacionados, os mecanismos que delineiam o desenvolvimento destes déficits cognitivos são, ainda, limitados. Neste contexto nós investigamos o envolvimento de marcadores de estresse…

Advisors/Committee Members: Adair Roberto Soares dos Santos, Luiz Fernando Freire Royes, Álvaro Reischak de Oliveira.

Subjects/Keywords: TBARS; carbonilação protéica; estresse oxidativo; Na+,K+-ATPase; TCE; FARMACIA; FPI; Na+,K+-ATPase; TBI; oxidative damage; protein carbonylation; TBARS; Barnes maze; physical exercise; exercício físico; labirinto de Barnes

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Lima, F. D. (2009). O papel da enzima Na+,K+-ATPase no déficit cognitivo e no efeito profilático induzido pelo exercício físico após o Traumatismo Crânio-Encefálico. (Thesis). Universidade Federal de Santa Maria. Retrieved from http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=2781

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Lima, Frederico Diniz. “O papel da enzima Na+,K+-ATPase no déficit cognitivo e no efeito profilático induzido pelo exercício físico após o Traumatismo Crânio-Encefálico.” 2009. Thesis, Universidade Federal de Santa Maria. Accessed June 16, 2019. http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=2781.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Lima, Frederico Diniz. “O papel da enzima Na+,K+-ATPase no déficit cognitivo e no efeito profilático induzido pelo exercício físico após o Traumatismo Crânio-Encefálico.” 2009. Web. 16 Jun 2019.

Vancouver:

Lima FD. O papel da enzima Na+,K+-ATPase no déficit cognitivo e no efeito profilático induzido pelo exercício físico após o Traumatismo Crânio-Encefálico. [Internet] [Thesis]. Universidade Federal de Santa Maria; 2009. [cited 2019 Jun 16]. Available from: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=2781.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lima FD. O papel da enzima Na+,K+-ATPase no déficit cognitivo e no efeito profilático induzido pelo exercício físico após o Traumatismo Crânio-Encefálico. [Thesis]. Universidade Federal de Santa Maria; 2009. Available from: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=2781

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.