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University of Melbourne
1.
GRIFFITH, JESSICA.
Characterisation of the leptin signalling targets in kidney development and obesity-related kidney disease.
Degree: 2015, University of Melbourne
URL: http://hdl.handle.net/11343/56393 
► The adipokine leptin regulates many biological functions including hunger and satiety, and organ development. Leptin has been implicated in the development of obesity-related kidney disease…
(more)
▼ The adipokine leptin regulates many biological functions including hunger and satiety, and organ development. Leptin has been implicated in the development of obesity-related kidney disease (via elevated leptin concentrations) and altered renal development (via low leptin concentrations). Most studies’ investigating the role of leptin in the pathogenesis of kidney disease has solely focused on the glomerulus, with no research investigating leptin’s effect on the proximal tubule, which is critical in renal albumin handling. To investigate this association Opossum kidney cells, an in vitro proximal tubule cell line, were acutely treated with leptin to identify the signalling mediators activated and to determine if leptin directly alters proximal tubular structure and function. Significantly, Chapter 3 and Chapter 4 reports that leptin activates signalling targets in the proximal tubule via megalin. This resulted in proximal tubular atrophy, upregulation of fibrotic mediator expression and impaired albumin handling. As obesity is a multifactorial disease, where a number of molecules are dysregulated, it is possible the changes observed in vitro, where leptin is elevated, will not translate to the obese state. To address this, Sprague Dawley rats were fed a high fat diet for 12 weeks and changes in fibrotic mediator expression and albumin handling were measured. Interestingly, Chapter 5 identified that consumption of a high fat diet did not alter fibrotic mediator expression in the kidney, but resulted in low molecular weight proteinuria.
Fetal growth restriction occurs in 10% of pregnancies worldwide and is characterised by a reduction in oxygen and nutrient transfer to the growing fetus. In Western cultures, the main cause of fetal growth restriction is due to uteroplacental insufficiency. Research in both humans and animals have well documented that fetal growth restriction reduces nephron number and increases the risk of cardiorenal disease in adulthood, with males being more severely affected. Additionally, cross-fostering studies have demonstrated that cross-fostering Restricted pups onto a Control mother with normal lactation restores the nephron deficit. Recent research has demonstrated that inhibiting leptin in the early postnatal period in rats reduces nephron number. To identify if leptin plays a role in the nephron deficit in fetal growth restriction, a rat model to mimic uteroplacental insufficiency was used, where the uterine vessels were bilaterally ligated during late pregnancy. Chapter 6 demonstrated that fetal growth restriction reduces plasma leptin concentrations, which was restored when these Restricted pups were cross-fostered onto a Control mother. Additionally, growth restriction altered pup renal leptin signalling targets, which were not restored with cross-fostering.
This thesis identifies that the maintenance of physiological plasma leptin concentrations is critical to human health. These studies have identified the role leptin plays in renal function and development when plasma leptin…
Subjects/Keywords: leptin; kidney; obesity; kidney development; kidney disease
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APA (6th Edition):
GRIFFITH, J. (2015). Characterisation of the leptin signalling targets in kidney development and obesity-related kidney disease. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/56393
Chicago Manual of Style (16th Edition):
GRIFFITH, JESSICA. “Characterisation of the leptin signalling targets in kidney development and obesity-related kidney disease.” 2015. Doctoral Dissertation, University of Melbourne. Accessed March 01, 2021.
http://hdl.handle.net/11343/56393.
MLA Handbook (7th Edition):
GRIFFITH, JESSICA. “Characterisation of the leptin signalling targets in kidney development and obesity-related kidney disease.” 2015. Web. 01 Mar 2021.
Vancouver:
GRIFFITH J. Characterisation of the leptin signalling targets in kidney development and obesity-related kidney disease. [Internet] [Doctoral dissertation]. University of Melbourne; 2015. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/11343/56393.
Council of Science Editors:
GRIFFITH J. Characterisation of the leptin signalling targets in kidney development and obesity-related kidney disease. [Doctoral Dissertation]. University of Melbourne; 2015. Available from: http://hdl.handle.net/11343/56393
University of Alberta
2.
Sun, Xuan.
Arsenic Speciation in Poultry Kidney.
Degree: MS, Department of Chemistry, 2014, University of Alberta
URL: https://era.library.ualberta.ca/files/cf7623c68k
► An organoarsenic compound, 3-nitro-4-hydroxyphenyl arsenic acid (also known as Roxarsone), has been used as a feed additive. Roxarsone was approved by the Food and Drug…
(more)
▼ An organoarsenic compound, 3-nitro-4-hydroxyphenyl
arsenic acid (also known as Roxarsone), has been used as a feed
additive. Roxarsone was approved by the Food and Drug
Administration (FDA) to control diseases in poultry, and to improve
weight gain, feed efficiency, and meat pigmentation. Contrary to
the previous belief that most of the Roxarsone is excreted
unchanged in the manure, researchers from the FDA recently reported
increases in inorganic arsenic concentration in the liver of a
small number of chickens fed with Roxarsone. This thesis focuses on
a much larger scale feeding study, involving a subset of 142
chickens from a total of 1600 chickens over a 35-day period. Within
this subset, 71 chickens were fed a Roxarsone-supplemented diet,
and the other 71 chickens were fed a control diet not supplemented
with Roxarsone. The objectives of this research are to develop a
method for arsenic speciation analysis and to quantify arsenic
species in chicken kidney. Kidney samples were treated with pepsin,
and the extracts were analyzed for arsenic species using high
performance liquid chromatography (HPLC) separation with
simultaneous detection by inductively coupled plasma mass
spectrometry (ICP-MS) and electrospray ionization tandem mass
spectrometry (ESI MS/MS). The temporal profile of each arsenic
species was acquired and the analyses show the presence of eleven
arsenic compounds in the extracts of the chicken kidney samples.
HPLC-ICP-MS allowed for the quantification of the arsenic species,
and ESI MS/MS provided complementary information for the
identification of the arsenic species. Results from the analyses of
both the control and the Roxarsone-fed chickens are important to
our understanding of arsenic metabolism, distribution, and
retention in chicken.
Subjects/Keywords: arsenic; kidney
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APA (6th Edition):
Sun, X. (2014). Arsenic Speciation in Poultry Kidney. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/cf7623c68k
Chicago Manual of Style (16th Edition):
Sun, Xuan. “Arsenic Speciation in Poultry Kidney.” 2014. Masters Thesis, University of Alberta. Accessed March 01, 2021.
https://era.library.ualberta.ca/files/cf7623c68k.
MLA Handbook (7th Edition):
Sun, Xuan. “Arsenic Speciation in Poultry Kidney.” 2014. Web. 01 Mar 2021.
Vancouver:
Sun X. Arsenic Speciation in Poultry Kidney. [Internet] [Masters thesis]. University of Alberta; 2014. [cited 2021 Mar 01].
Available from: https://era.library.ualberta.ca/files/cf7623c68k.
Council of Science Editors:
Sun X. Arsenic Speciation in Poultry Kidney. [Masters Thesis]. University of Alberta; 2014. Available from: https://era.library.ualberta.ca/files/cf7623c68k
McMaster University
3.
KITALA, PATRICIA.
Characterization of the Role of Shroom3 in Nephron Formation.
Degree: MSMS, 2019, McMaster University
URL: http://hdl.handle.net/11375/24826
► Proper development of the nephron, the functional unit of the kidney, is essential for kidney function. The nephron develops from a pool of cap mesenchymal…
(more)
▼ Proper development of the nephron, the functional unit of the kidney, is essential for
kidney function. The nephron develops from a pool of cap mesenchymal cells, as defined
by a cluster of cells adjacent to the ureteric bud tips of branching ureteric epithelium,
giving rise to two subset populations: the self renewing cells and the nephron progenitors.
These nephron progenitors undergo mesenchymal-epithelial transition (MET) to develop
into polarized renal vesicles (RV), and eventually fuse with the epithelial tubule to
develop into a mature nephron. Although these processes are essential for the formation
of functional kidneys, little is known about the molecular mechanisms that regulate them.
In this study, we characterize several steps during cap mesenchyme and renal vesicle
formation using our Shroom3 knockout mouse kidney as our model. Previous researchers
have associated Shroom3 with chronic kidney disease. Detecting and analyzing the
genetic components of CKD is needed to improve our understanding of its pathogenesis.
Shroom3 encodes an actin-binding protein that regulates cell shape changes through
induction of apical constriction. However, there is a lack of evidence about Shroom3’s
expression pattern and functional role upstream of developed nephrons. Here, I defined
the spatial and temporal expression of Shroom3 within the cap mesenchyme region. I
investigated the nephron progenitors between Shroom3 wildtypes and mutants. Lastly, I
analyzed the renal vesicle polarity in mutants, by analyzing apical membrane markers on
RVs to characterize any abnormalities in their orientation and establishment of polarity.
Thesis
Master of Science in Medical Sciences (MSMS)
Advisors/Committee Members: BRIDGEWATER, DARREN.
Subjects/Keywords: Shroom3; Kidney
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APA (6th Edition):
KITALA, P. (2019). Characterization of the Role of Shroom3 in Nephron Formation. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/24826
Chicago Manual of Style (16th Edition):
KITALA, PATRICIA. “Characterization of the Role of Shroom3 in Nephron Formation.” 2019. Masters Thesis, McMaster University. Accessed March 01, 2021.
http://hdl.handle.net/11375/24826.
MLA Handbook (7th Edition):
KITALA, PATRICIA. “Characterization of the Role of Shroom3 in Nephron Formation.” 2019. Web. 01 Mar 2021.
Vancouver:
KITALA P. Characterization of the Role of Shroom3 in Nephron Formation. [Internet] [Masters thesis]. McMaster University; 2019. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/11375/24826.
Council of Science Editors:
KITALA P. Characterization of the Role of Shroom3 in Nephron Formation. [Masters Thesis]. McMaster University; 2019. Available from: http://hdl.handle.net/11375/24826
University of Illinois – Chicago
4.
Yoo, Jongwon.
Predicting One-year Kidney Graft Failure and Death with Cardiovascular and Immunological Factors.
Degree: 2016, University of Illinois – Chicago
URL: http://hdl.handle.net/10027/20887
► Cardiovascular and immunological factors increase the levels of uncertainty and risk associated with transplantation. Kidney transplant programs are reluctant to risk performing transplant surgery on…
(more)
▼ Cardiovascular and immunological factors increase the levels of uncertainty and risk associated with transplantation.
Kidney transplant programs are reluctant to risk performing transplant surgery on high risk candidates because of poor outcomes. Patients with high risk have limited access to
kidney transplantation in spite of possible survival benefits of
kidney transplantation. We developed four predictive models according to donor types (living donor- and deceased donor-) and transplant outcomes (graft failure and patient death) using national transplant registry data (Scientific Registry Transplant Recipients, n = 218,657) which have different probabilities of one-year
kidney graft failure and death compared to the currently used models. We showed that by including two more risk factors in the analyses that current models underestimate predicted risks. The two factors were cardiovascular comorbidities and immunological barriers. The predictive models showed risk of high risk candidates were underestimated by current predictive models. If transplant community used our models, they would find that predicted risk of failure is higher and more generous. Then, more high risk patients could have access to
kidney transplantation without the transplant programs’ jeopardizing theirs status as high quality programs. The predictive models were shown to be valid and reliable.These models will help (1) quantify risks of transplant outcomes in high-risk candidates, (2) screen the most appropriate candidates and eventually, (3) improve accessibility of
kidney transplantation and (4) better utilize the most limited and scarce resources, donated kidneys.
Advisors/Committee Members: Ryan, Catherine (advisor), Matthews, Alicia (committee member), Murks, Catherine (committee member), Puzantian, Houry (committee member), Park, Chang Gi (committee member), Quinn, Lauretta (committee member), Collins, Eileen (committee member).
Subjects/Keywords: Kidney; Transplantation
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APA (6th Edition):
Yoo, J. (2016). Predicting One-year Kidney Graft Failure and Death with Cardiovascular and Immunological Factors. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/20887
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Yoo, Jongwon. “Predicting One-year Kidney Graft Failure and Death with Cardiovascular and Immunological Factors.” 2016. Thesis, University of Illinois – Chicago. Accessed March 01, 2021.
http://hdl.handle.net/10027/20887.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Yoo, Jongwon. “Predicting One-year Kidney Graft Failure and Death with Cardiovascular and Immunological Factors.” 2016. Web. 01 Mar 2021.
Vancouver:
Yoo J. Predicting One-year Kidney Graft Failure and Death with Cardiovascular and Immunological Factors. [Internet] [Thesis]. University of Illinois – Chicago; 2016. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/10027/20887.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Yoo J. Predicting One-year Kidney Graft Failure and Death with Cardiovascular and Immunological Factors. [Thesis]. University of Illinois – Chicago; 2016. Available from: http://hdl.handle.net/10027/20887
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
McGill University
5.
Musey, Paul Isaac.
Metabolism of free and conjugated estrogens by renal preparations in vitro.
Degree: MS, Department of Biochemistry, 1969, McGill University
URL: https://escholarship.mcgill.ca/downloads/h989r567d.pdf
;
https://escholarship.mcgill.ca/concern/theses/z603r1098
► Renal tissue homogenates of different species: rat, hen, rabbit and dog were used to study the metabolism of 3H-Estrone (El), Estradiol 17S (Ez); Estrone Sulfate…
(more)
▼ Renal tissue homogenates of different species: rat, hen, rabbit and dog were used to study the metabolism of 3H-Estrone (El), Estradiol 17S (Ez); Estrone Sulfate (EIS) and Estradiol 17S glucuronide (EZG) separately. The metabolites were separated by various extraction procedures and the conjugates investigated by chromatography on DEAE-sephadex. The main steroid found following incubation of El or Ez in all species was El. This agrees with most in vitro studies except where gonadal tissue is concerned. More polar metabolites were virtually absent and there was no evidence of sulfurylation having occurred. Some glucuronide formation was apparent. Incubation of EIS showed a wide range of sulfatase activities, extremely high in the rat and very low in the dog. The hen, followed by the rabbit showed intermediate values.
Kidney preparations from rabbit and dog appeared capable of metabolizing EIS without prior hydrolysis. Little evidence was obtained for the presence of significant S-glucuronidase activity in these tissues. On occasion it appeared that EzG could be converted to conjugated metabolites probably the N-acetyl glucosamine derivative.
Advisors/Committee Members: Hobkirk, R. (Supervisor).
Subjects/Keywords: Kidney
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APA (6th Edition):
Musey, P. I. (1969). Metabolism of free and conjugated estrogens by renal preparations in vitro. (Masters Thesis). McGill University. Retrieved from https://escholarship.mcgill.ca/downloads/h989r567d.pdf ; https://escholarship.mcgill.ca/concern/theses/z603r1098
Chicago Manual of Style (16th Edition):
Musey, Paul Isaac. “Metabolism of free and conjugated estrogens by renal preparations in vitro.” 1969. Masters Thesis, McGill University. Accessed March 01, 2021.
https://escholarship.mcgill.ca/downloads/h989r567d.pdf ; https://escholarship.mcgill.ca/concern/theses/z603r1098.
MLA Handbook (7th Edition):
Musey, Paul Isaac. “Metabolism of free and conjugated estrogens by renal preparations in vitro.” 1969. Web. 01 Mar 2021.
Vancouver:
Musey PI. Metabolism of free and conjugated estrogens by renal preparations in vitro. [Internet] [Masters thesis]. McGill University; 1969. [cited 2021 Mar 01].
Available from: https://escholarship.mcgill.ca/downloads/h989r567d.pdf ; https://escholarship.mcgill.ca/concern/theses/z603r1098.
Council of Science Editors:
Musey PI. Metabolism of free and conjugated estrogens by renal preparations in vitro. [Masters Thesis]. McGill University; 1969. Available from: https://escholarship.mcgill.ca/downloads/h989r567d.pdf ; https://escholarship.mcgill.ca/concern/theses/z603r1098
McMaster University
6.
Khalili, Hadiseh.
SHROOM3 IN THE KIDNEY.
Degree: MSc, 2015, McMaster University
URL: http://hdl.handle.net/11375/17413
► Chronic kidney disease (CKD), defined as an irreversible reduction in glomerular filtration rate, is a large public health concern. Dissecting the genetic components of CKD…
(more)
▼ Chronic kidney disease (CKD), defined as an irreversible reduction in glomerular filtration rate, is a large public health concern. Dissecting the genetic components of CKD is required to improve our understanding of disease pathogenesis. Researchers have identified that SHROOM3, has very high associations with kidney disease and function. Shroom3 encodes an actin-binding protein important in regulating cell and tissue morphogenesis. However, there is a lack of evidence supporting a role for Shroom3 in kidney function or disease. Here, I investigated the developmental and functional role of Shroom3 in the mammalian kidney. For the first time, I described the expression pattern of Shroom3 in the embryonic and adult mouse kidneys. By performing in situ hybridization and immunohistochemistry, I demonstrated that Shroom3 is expressed in the condensing mesenchyme, podocytes, and collecting ducts. I further showed that Shroom3 protein is localized in the foot processes of podocytes, utilizing immunogold labeling and transmission electron microscopy. In order to uncover a potential role of Shroom3 in the kidney, we utilized Shroom3 knockout mice. Shroom3 mutants demonstrated marked glomerular abnormalities including cystic and degenerating glomeruli, and reduced glomerular number. Scanning and transmission electron microscopic analyses of Shroom3 mutant glomeruli revealed disruptions in podocyte morphology characterized by disorganized foot processes with less interdigitation and segmental foot processes effacement. Furthermore, immunofluorescence analysis of mutant kidneys revealed aberrant distribution of podocyte actin-associated proteins. Elucidating the underlying molecular mechanism of this abnormal podocyte architecture;
v
we demonstrated that in the absence of Shroom3, Rho kinase is mislocalized in the apical membrane of podocytes. As a result, mislocalized Rho kinase failed to phosphorylate non-muscle myosin and induce actomyosin contraction resulting in a patchy granular distribution of actin in the podocytes of Shroom3 mutants. Taken together, our findings established that Shroom3 is essential for proper actin organization in the podocytes through interaction with Rock. Furthermore, we took advantage of a haploinsufficiency phenotype of Shroom3 heterozygote adult mice and demonstrated these mice develop glomerulosclerosis and proteinuria. In conclusion, our studies provided evidence to support a role for Shroom3 in kidney development and disease and support the GWAS studies that suggested a correlation between SHROOM3 variants and kidney function in humans.
Thesis
Master of Science (MSc)
Advisors/Committee Members: Bridgewater, Darren, Medical Sciences.
Subjects/Keywords: Kidney; Glomerulus; Podocyte; Shroom3; CKD; Kidney Development
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APA (6th Edition):
Khalili, H. (2015). SHROOM3 IN THE KIDNEY. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/17413
Chicago Manual of Style (16th Edition):
Khalili, Hadiseh. “SHROOM3 IN THE KIDNEY.” 2015. Masters Thesis, McMaster University. Accessed March 01, 2021.
http://hdl.handle.net/11375/17413.
MLA Handbook (7th Edition):
Khalili, Hadiseh. “SHROOM3 IN THE KIDNEY.” 2015. Web. 01 Mar 2021.
Vancouver:
Khalili H. SHROOM3 IN THE KIDNEY. [Internet] [Masters thesis]. McMaster University; 2015. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/11375/17413.
Council of Science Editors:
Khalili H. SHROOM3 IN THE KIDNEY. [Masters Thesis]. McMaster University; 2015. Available from: http://hdl.handle.net/11375/17413
Victoria University of Wellington
7.
Anderson, Olivia.
Transplant Tourism: New Zealand Residents Deciding on Commercial Transplantation Overseas.
Degree: 2020, Victoria University of Wellington
URL: http://hdl.handle.net/10063/8885
► The demand for organs exceeds supply in almost every country, including New Zealand. As such, scholars have argued that this has contributed to a rise…
(more)
▼ The demand for organs exceeds supply in almost every country, including New Zealand. As such, scholars have argued that this has contributed to a rise in illegal
kidney purchase and commercial transplantation. Taking into account the likelihood that patients in New Zealand have been involved, this research considers the factors that motivate these patients to circumvent the transplant opportunities here in favour of a commercial transplant overseas. In addition, this project examines the ethical concerns that arise for medical professionals who suspect or become aware of a patient’s intention to procure an organ outside of New Zealand. Interviews were conducted with eight medical professionals working in the field of
kidney donation and transplantation, two key informants (stakeholder and academic), and two patients. The patients have previously undergone a
kidney transplant in New Zealand and have both — to varying degrees — considered transplant tourism. Using narrative thematic analysis, the data was organised into three predominant themes; The Desire for Health, Transplant Tourism: An Uncommon Phenomenon, and The Healthcare Response. Numerous insights were generated from this analysis. While transplant tourism is considered by many patients in New Zealand, it is pursued infrequently and arguably only by those with connections to common destination countries. When such instances occur, medical professionals in New Zealand encounter a variety of ethical, legal, and professional dilemmas that affect their ability to prevent transplantrelated crimes. This research concludes that patients (regardless of whether or not they pursue transplant tourism) experience feelings of frustration and hopelessness as a result of their illness experiences along with the current healthcare infrastructures. Assisting patients in setting realistic expectations of their treatment options, as well as increasing the transparency of the deceased donor waiting list is recommended. Moreover, it is suggested that transplant professionals at all levels are offered education about organ trafficking and transplant tourism, and a policy statement on organ trafficking and transplant tourism should be developed to clarify the rights and obligations of medical professionals in relation to organ purchase and offer guidance on how they can interact with patients who travel or plan to travel abroad for a transplant.
Advisors/Committee Members: Shaw, Rhonda.
Subjects/Keywords: Kidney donation; Commercial transplantation; Kidney trade
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APA (6th Edition):
Anderson, O. (2020). Transplant Tourism: New Zealand Residents Deciding on Commercial Transplantation Overseas. (Masters Thesis). Victoria University of Wellington. Retrieved from http://hdl.handle.net/10063/8885
Chicago Manual of Style (16th Edition):
Anderson, Olivia. “Transplant Tourism: New Zealand Residents Deciding on Commercial Transplantation Overseas.” 2020. Masters Thesis, Victoria University of Wellington. Accessed March 01, 2021.
http://hdl.handle.net/10063/8885.
MLA Handbook (7th Edition):
Anderson, Olivia. “Transplant Tourism: New Zealand Residents Deciding on Commercial Transplantation Overseas.” 2020. Web. 01 Mar 2021.
Vancouver:
Anderson O. Transplant Tourism: New Zealand Residents Deciding on Commercial Transplantation Overseas. [Internet] [Masters thesis]. Victoria University of Wellington; 2020. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/10063/8885.
Council of Science Editors:
Anderson O. Transplant Tourism: New Zealand Residents Deciding on Commercial Transplantation Overseas. [Masters Thesis]. Victoria University of Wellington; 2020. Available from: http://hdl.handle.net/10063/8885
University of Minnesota
8.
Leither, Maxwell.
Outpatient Acute Kidney Injury Increases Risk of Mortality and Chronic Kidney Disease.
Degree: MS, Clinical Research, 2017, University of Minnesota
URL: http://hdl.handle.net/11299/198958
► Introduction: Limited data exist regarding outcomes of patients with outpatient acute kidney injury (AKI). To determine whether outpatient AKI is associated with increased mortality and…
(more)
▼ Introduction: Limited data exist regarding outcomes of patients with outpatient acute kidney injury (AKI). To determine whether outpatient AKI is associated with increased mortality and chronic kidney disease (CKD), we conducted a retrospective cohort study utilizing an electronic health record in Minnesota. Methods: All adult patients receiving primary care through Fairview Health Services were included. All outpatient Cr values during an 18 month exposure period were used to define five comparator groups as follows: No outpatient AKI (reference group), outpatient AKI with recovery, outpatient AKI without recovery, outpatient AKI without repeat Cr, or no Cr. A Cox proportional hazard model was utilized to assess whether outpatient AKI was associated with an increase in mortality, CKD stage 4 and secondary outcomes including hospitalization and recurrent AKI. Results: The cohort consisted of 384,869 patients and 51% had at least one Cr measured during the exposure period. Outpatient AKI occurred in 1.4% of patients during the 18 month exposure period and 37.8% recovered while 26.5% had no repeat Cr. Mortality was 3.2% over an average follow-up of 5.3 years. Outpatient AKI was associated with an increased risk of mortality (aHR 1.90, 95% CI 1.76-2.06) and CKD stage 4 (aHR 1.33, 95% CI 1.11-1.59) including those that recovered from their AKI (mortality aHR 2.15, 95% CI 1.91-2.41; CKD aHR 1.73, 95% CI 1.37-2.19) and in those with stage 1 AKI (mortality aHR 1.90, 95% CI 1.74-2.07; CKD aHR 1.34, 95% CI 1.10-1.62). Outpatient AKI was also associated with with an increased risk of hospitalization (aHR 1.71, 95% CI 1.63-1.79), hospital AKI (aHR 2.14, 95% CI 1.93-2.37), and recurrent outpatient AKI (aHR 2.75, 95% CI 2.57-2.93). Conclusion: Outpatient AKI is common and is a risk factor for death, CKD, hospitalization, and recurrent AKI, including those with stage 1 AKI and those that recover.
Subjects/Keywords: acute kidney injury; chronic kidney disease; nephrology
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APA (6th Edition):
Leither, M. (2017). Outpatient Acute Kidney Injury Increases Risk of Mortality and Chronic Kidney Disease. (Masters Thesis). University of Minnesota. Retrieved from http://hdl.handle.net/11299/198958
Chicago Manual of Style (16th Edition):
Leither, Maxwell. “Outpatient Acute Kidney Injury Increases Risk of Mortality and Chronic Kidney Disease.” 2017. Masters Thesis, University of Minnesota. Accessed March 01, 2021.
http://hdl.handle.net/11299/198958.
MLA Handbook (7th Edition):
Leither, Maxwell. “Outpatient Acute Kidney Injury Increases Risk of Mortality and Chronic Kidney Disease.” 2017. Web. 01 Mar 2021.
Vancouver:
Leither M. Outpatient Acute Kidney Injury Increases Risk of Mortality and Chronic Kidney Disease. [Internet] [Masters thesis]. University of Minnesota; 2017. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/11299/198958.
Council of Science Editors:
Leither M. Outpatient Acute Kidney Injury Increases Risk of Mortality and Chronic Kidney Disease. [Masters Thesis]. University of Minnesota; 2017. Available from: http://hdl.handle.net/11299/198958
University of Alberta
9.
Aderibigbe, Ayodeji O.
The Regulation of Na+/H+ Exchanger Isoform 1 in Kidney
Cells.
Degree: PhD, Department of Biochemistry, 2016, University of Alberta
URL: https://era.library.ualberta.ca/files/cnv935307z
► The mammalian Na+/H+ exchanger isoform 1 (NHE1) is a ubiquitous plasma membrane protein that regulates intracellular pH by removing a proton in exchange for extracellular…
(more)
▼ The mammalian Na+/H+ exchanger isoform 1 (NHE1) is a
ubiquitous plasma membrane protein that regulates intracellular pH
by removing a proton in exchange for extracellular sodium. NHE1 is
expressed in many tissues including the kidney where it has been
demonstrated to play essential roles in pH and cell volume
regulation. It has also been implicated in some pathological
conditions of the kidney including ischemia and chronic kidney
diseases. NHE1 has a large 315 amino-acid cytosolic regulatory
domain that regulates the catalytic membrane domain. The cytosolic
domain is mainly regulated by phosphorylation and protein
interaction. This study examined how these regulatory mechanisms
regulate NHE1 in kidney cells. The activation of NHE1 in myocardial
cells by sustained intracellular acidosis (SIA) was shown to be
mediated by ERK1/2 phosphorylation. In this study, we also
demonstrate that SIA stimulates NHE1 activity in Mardin-Darby
Canine Kidney (MDCK) cells. To characterize how SIA stimulates NHE1
in kidney cells, wild-type and mutant NHE1 cDNAs were stably
expressed in MDCK cells and examined for activation and
phosphorylation in response to SIA. All the cDNAs had a L163F/G174S
mutation, which conferred a 100-fold resistance to EMD87580, an
NHE1-specific inhibitor. This allowed us to assay exogenous NHE1
activity while inhibiting endogenous activity with EMD87580 and
while inhibiting the NHE3 isoform of the Na⁺/H⁺ exchanger using the
isoform-specific inhibitor S3226. We demonstrated that the amino
acids Ser771, Ser776, Thr779, and Ser785 are important for NHE1
phosphorylation and activation after acute SIA. SIA also activated
ERK-dependent pathways in MDCK cells, and this was blocked by
treatment with the MEK inhibitor U0126. Treatment with U0126 also
blocked activation of NHE1 by SIA. These results suggest that acute
acidosis activates NHE1 in mammalian kidney cells and that in MDCK
cells this activation occurs through phosphorylation of a distinct
set of amino acids in the cytosolic regulatory tail of NHE1 by
ERK1/2. We also examined how protein interaction regulates NHE1
activity. Using affinity chromatography with the C-terminus of
NHE1, we determined the NHE1 binding proteins in the kidney which
includes 14-3-3 protein, heat shock proteins (Hsp90 and Hsp70) and
Na+/K+ ATPase. We also confirmed that 14-3-3 and heat shock
proteins bind to or regulate NHE1 but could not confirm that Na+/K+
ATPase binds to the intact protein. The Hsp90 inhibitor 17-AAG
decreased NHE1 activity and NHE1 phosphorylation in MDCK cells but
did not decrease protein levels. Additionally, 17-AAG decreased
phospho-AKT levels. Direct inhibition of AKT with MK2206 decreased
NHE1 activity, though this effect was not additive with the effect
of 17-AAG. These results are the first demonstration that in renal
cells, NHE1 is associated with several regulatory proteins
including Hsp90, and suggest that this interaction affect NHE1
function through altered phosphorylation of the protein via the AKT
kinase.
Subjects/Keywords: NHE1; Kidney; Acidosis
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APA (6th Edition):
Aderibigbe, A. O. (2016). The Regulation of Na+/H+ Exchanger Isoform 1 in Kidney
Cells. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/cnv935307z
Chicago Manual of Style (16th Edition):
Aderibigbe, Ayodeji O. “The Regulation of Na+/H+ Exchanger Isoform 1 in Kidney
Cells.” 2016. Doctoral Dissertation, University of Alberta. Accessed March 01, 2021.
https://era.library.ualberta.ca/files/cnv935307z.
MLA Handbook (7th Edition):
Aderibigbe, Ayodeji O. “The Regulation of Na+/H+ Exchanger Isoform 1 in Kidney
Cells.” 2016. Web. 01 Mar 2021.
Vancouver:
Aderibigbe AO. The Regulation of Na+/H+ Exchanger Isoform 1 in Kidney
Cells. [Internet] [Doctoral dissertation]. University of Alberta; 2016. [cited 2021 Mar 01].
Available from: https://era.library.ualberta.ca/files/cnv935307z.
Council of Science Editors:
Aderibigbe AO. The Regulation of Na+/H+ Exchanger Isoform 1 in Kidney
Cells. [Doctoral Dissertation]. University of Alberta; 2016. Available from: https://era.library.ualberta.ca/files/cnv935307z
University of Alberta
10.
MacDonald, Christine, L.
Acute Kidney Injury After Heart Transplant in Children; Risk
Factors and Outcomes.
Degree: Master of Nursing, Faculty of Nursing, 2015, University of Alberta
URL: https://era.library.ualberta.ca/files/kp78gj706
► Background: Heart transplant is life-saving for children with end-stage congenital heart disease or acquired heart failure. Critical illness following transplantation can include acute kidney injury…
(more)
▼ Background: Heart transplant is life-saving for
children with end-stage congenital heart disease or acquired heart
failure. Critical illness following transplantation can include
acute kidney injury (AKI). There is little data on the epidemiology
of, risk factors for, or impact on outcomes of AKI after pediatric
heart transplant. Methods: Using secondary analysis of data from an
ongoing prospective cohort study, we evaluated 72 children (0- 5
yrs) who had a heart transplant between 2001 and 2012. We
evaluated: 1) postoperative AKI rate (defined by pRIFLE); 2) pre-,
intra-, and early postoperative AKI risk factors (days on waitlist,
inotrope use and ventilation pre-transplant, ECMO / ventricular
assist device at transplant, preoperative estimated glomerular
filtration rate (eGFR), ABO incompatibility, donor ischemic time,
peak intraoperative lactate, tacrolimus level early
postoperatively) using stepwise logistic regression; 3) effect of
AKI on short-term outcomes (duration of ventilation and length of
PICU stay). Results: AKI occurred in 73% of children. Independent
predictors of AKI were pre-transplant ventilation (OR 8.6, p=0.007)
and higher eGFR (p=0.032). Following adjustment, preoperative
inotrope significantly reduced the risk of AKI (OR 0.13, p=0.016).
Sixteen percent of children had a tacrolimus level >15 ug/L
on day 3 post-transplant and these children had more AKI than
children without (OR 7.8, p=0.086). Although not statistically
significant, automated model selection retained tacrolimus level
>15 ug/L as a predictor (using multiple different modeling
strategies). AKI resulted in longer ventilation days and ICU stay
(p=0.038 & p=0.004, respectively). Conclusion: AKI was
common after heart transplant and was associated with important
outcomes. As in other pediatric cardiac surgery populations, lower
preoperative GFR was protective against postoperative AKI; the role
of modified immune suppressive strategies in this context needs to
be further evaluated. Although not statistically significant,
elevated early postoperative tacrolimus is likely biologically
important in the prediction of AKI risk and needs further
evaluation in a larger cohort.
Subjects/Keywords: Heart; Kidney; Transplant
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Manager
APA (6th Edition):
MacDonald, Christine, L. (2015). Acute Kidney Injury After Heart Transplant in Children; Risk
Factors and Outcomes. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/kp78gj706
Chicago Manual of Style (16th Edition):
MacDonald, Christine, L. “Acute Kidney Injury After Heart Transplant in Children; Risk
Factors and Outcomes.” 2015. Masters Thesis, University of Alberta. Accessed March 01, 2021.
https://era.library.ualberta.ca/files/kp78gj706.
MLA Handbook (7th Edition):
MacDonald, Christine, L. “Acute Kidney Injury After Heart Transplant in Children; Risk
Factors and Outcomes.” 2015. Web. 01 Mar 2021.
Vancouver:
MacDonald, Christine L. Acute Kidney Injury After Heart Transplant in Children; Risk
Factors and Outcomes. [Internet] [Masters thesis]. University of Alberta; 2015. [cited 2021 Mar 01].
Available from: https://era.library.ualberta.ca/files/kp78gj706.
Council of Science Editors:
MacDonald, Christine L. Acute Kidney Injury After Heart Transplant in Children; Risk
Factors and Outcomes. [Masters Thesis]. University of Alberta; 2015. Available from: https://era.library.ualberta.ca/files/kp78gj706
Vanderbilt University
11.
Norlander, Allison Elizabeth.
SGK1, influenced by salt and IL-17A, promotes hypertension and end-organ damage.
Degree: PhD, Molecular Physiology and Biophysics, 2017, Vanderbilt University
URL: http://hdl.handle.net/1803/11007
► Hypertension is a leading cause of cardiovascular morbidity and mortality, leading to myocardial infarction, heart failure, stroke, and chronic kidney disease. We have previously shown…
(more)
▼ Hypertension is a leading cause of cardiovascular morbidity and mortality, leading to myocardial infarction, heart failure, stroke, and chronic
kidney disease. We have previously shown that the pro-inflammatory cytokine interleukin-17A (IL-17A) plays a critical role in angiotensin II-induced hypertension and vascular dysfunction. Additionally, many studies have demonstrated a link between increased dietary salt intake and hypertension. Recently, excess salt has been shown to promote the differentiation of CD4+ T cells into pathogenic IL-17A-producing Th17 cells via a serum and glucocorticoid-regulated kinase 1 (SGK1) dependent pathway in CD4+ T cells. Classically, SGK1 is known to play an important role in the stabilization of distal sodium transporters in the
kidney. Thus, we sought to investigate the role of T cell SGK1 in the development of hypertension and the mechanism by which IL17A promotes renal dysfunction in hypertension. We found that T cell SGK1 is essential for the maintenance of both angiotensin II and deoxycorticosterone acetate (DOCA) salt-induced hypertension. T cell SGK1 deficient mice exhibited blunted blood pressure, abrogated renal/vascular inflammation, and preserved renal/vascular function in response to hypertensive stimuli. Moreover, we found that IL-17A regulates proximal and distal tubule sodium transporters in the
kidney via an SGK1 dependent pathway. Together, these data demonstrate that IL-17A and SGK1 may be important therapeutic targets for hypertension.
Advisors/Committee Members: Raymond Harris (committee member), Jacek Hawiger (committee member), Katherine Murray (committee member), Jens Titze (committee member), Alyssa Hasty (Committee Chair).
Subjects/Keywords: immunology; hypertension; kidney
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APA (6th Edition):
Norlander, A. E. (2017). SGK1, influenced by salt and IL-17A, promotes hypertension and end-organ damage. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/11007
Chicago Manual of Style (16th Edition):
Norlander, Allison Elizabeth. “SGK1, influenced by salt and IL-17A, promotes hypertension and end-organ damage.” 2017. Doctoral Dissertation, Vanderbilt University. Accessed March 01, 2021.
http://hdl.handle.net/1803/11007.
MLA Handbook (7th Edition):
Norlander, Allison Elizabeth. “SGK1, influenced by salt and IL-17A, promotes hypertension and end-organ damage.” 2017. Web. 01 Mar 2021.
Vancouver:
Norlander AE. SGK1, influenced by salt and IL-17A, promotes hypertension and end-organ damage. [Internet] [Doctoral dissertation]. Vanderbilt University; 2017. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/1803/11007.
Council of Science Editors:
Norlander AE. SGK1, influenced by salt and IL-17A, promotes hypertension and end-organ damage. [Doctoral Dissertation]. Vanderbilt University; 2017. Available from: http://hdl.handle.net/1803/11007
12.
Madhvi Awasthi.
Counseling of kidney stone patients based on their
dietary pattern in the selected areas of district kangra
HP;.
Degree: 2013, INFLIBNET
URL: http://shodhganga.inflibnet.ac.in/handle/10603/10257
► The present study was planned and executed with the specific objectives to counsel the kidney stone patients based on their dietary pattern in the selected…
(more)
▼ The present study was planned and executed with the
specific objectives to counsel the kidney stone patients based on
their dietary pattern in the selected areas of district Kangra
(Himachal Pradesh). Out of total 130 selected kidney stone
patients, majority were males varying in their time of stone
diagnosis, symptoms of the disease, recurrence and inheritance of
stones and anthropometrical measurements. Majority of patients were
non-vegetarian with normal body weight. Their intake of macro
nutrient and water was lower than RDA while intake of minerals
(sodium, calcium and phosphorus) and oxalates was higher than RDA
which may be a contributory factor of stone formation. The
assessment of knowledge regarding general nutrition awareness,
knowledge regarding kidney stones and knowledge regarding nutrition
and kidney stone was done and nutrition education was also provided
to patients. There was positive correlation between literacy level
and general nutrition awareness and literacy level and nutrition
and kidney stones. Correlation study between literacy level and
gain in knowledge regarding kidney stones after nutrition education
was also positive. Overall comparison of mean gain and quantum of
improvement in knowledge of three categories revealed that there
was more gain and improvement of knowledge regarding nutrition and
kidney stones and more than half of respondents had gain in
knowledge categorized as high. The study revealed that if patients
are counseled and guided properly in the selection of appropriate
foods, much of recurrence and complications of kidneys can be
prevented thereby improving the general health. Proper nutrition
can support healthy kidney function and may discourage stone
formation. newline
Advisors/Committee Members: Dr. (Mrs.) S.R. Malhotra.
Subjects/Keywords: Dietary; kidney stone
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Manager
APA (6th Edition):
Awasthi, M. (2013). Counseling of kidney stone patients based on their
dietary pattern in the selected areas of district kangra
HP;. (Thesis). INFLIBNET. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/10257
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Awasthi, Madhvi. “Counseling of kidney stone patients based on their
dietary pattern in the selected areas of district kangra
HP;.” 2013. Thesis, INFLIBNET. Accessed March 01, 2021.
http://shodhganga.inflibnet.ac.in/handle/10603/10257.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Awasthi, Madhvi. “Counseling of kidney stone patients based on their
dietary pattern in the selected areas of district kangra
HP;.” 2013. Web. 01 Mar 2021.
Vancouver:
Awasthi M. Counseling of kidney stone patients based on their
dietary pattern in the selected areas of district kangra
HP;. [Internet] [Thesis]. INFLIBNET; 2013. [cited 2021 Mar 01].
Available from: http://shodhganga.inflibnet.ac.in/handle/10603/10257.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Awasthi M. Counseling of kidney stone patients based on their
dietary pattern in the selected areas of district kangra
HP;. [Thesis]. INFLIBNET; 2013. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/10257
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Addis Ababa University
13.
Afewerki, Bekele.
Project paper on: The effect of zinc exposure on the histology of liver and kidney
.
Degree: 2014, Addis Ababa University
URL: http://etd.aau.edu.et/dspace/handle/123456789/5190
► Summary Zinc is one of the most important trace elements in the body that participates in the biological function of several proteins and enzymes. Despite…
(more)
▼ Summary
Zinc is one of the most important trace elements in the body that participates in the biological function of several proteins and enzymes. Despite the fact that small quantity of zinc is required for the normal development and metabolism, its effect is toxic when a certain concentration is exceeded. The aim of this paper is to review scientific literatures on the protective and toxic effect of zinc exposure on the histology of liver and
kidney. The studies were evaluated in relation to dose of zinc, zinc combination with other toxic metals, duration of exposure, type of animal model used, method of study used and parameter used to measure protective effect of zinc against toxic metals and toxic effect of zinc alone. The different literatures reviewed in this paper used rats, mice, lambs, fishes, ducks. The literature reviewed showed that Zn administration together with Al, Cd, as well as organic solvent such as ethanol has a protective effect against Al, Cd induced toxicity in liver and
kidney tissues and ethanol induced toxicity in liver tissue. On the other hand, as zinc dose level and duration of the exposure increases, it act as toxic metal to histology of liver and
kidney.
Advisors/Committee Members: Girma Seyoum (PhD) (advisor).
Subjects/Keywords: zinc; liver; kidney
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Manager
APA (6th Edition):
Afewerki, B. (2014). Project paper on: The effect of zinc exposure on the histology of liver and kidney
. (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/5190
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Afewerki, Bekele. “Project paper on: The effect of zinc exposure on the histology of liver and kidney
.” 2014. Thesis, Addis Ababa University. Accessed March 01, 2021.
http://etd.aau.edu.et/dspace/handle/123456789/5190.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Afewerki, Bekele. “Project paper on: The effect of zinc exposure on the histology of liver and kidney
.” 2014. Web. 01 Mar 2021.
Vancouver:
Afewerki B. Project paper on: The effect of zinc exposure on the histology of liver and kidney
. [Internet] [Thesis]. Addis Ababa University; 2014. [cited 2021 Mar 01].
Available from: http://etd.aau.edu.et/dspace/handle/123456789/5190.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Afewerki B. Project paper on: The effect of zinc exposure on the histology of liver and kidney
. [Thesis]. Addis Ababa University; 2014. Available from: http://etd.aau.edu.et/dspace/handle/123456789/5190
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – San Francisco
14.
Du, David.
Effects of Periodontal Treatment on Diabetes and Chronic Kidney Disease.
Degree: Oral and Craniofacial Sciences, 2015, University of California – San Francisco
URL: http://www.escholarship.org/uc/item/02k290s0
► Introduction: Periodontitis affects 47.2% of the US population and 64% of adults over 65 (20). Chronic kidney disease (CKD) affects an estimated 13% to 16%…
(more)
▼ Introduction: Periodontitis affects 47.2% of the US population and 64% of adults over 65 (20). Chronic kidney disease (CKD) affects an estimated 13% to 16% of the US population and accounts for 27% of Medicare spending in 2007 (1). The central question (PICO) in this study is: In a population of patients with compromised renal function, is there a difference in reduction of systemic markers of HBA1C and serum albumin between the intensive periodontal intervention and community treatment group? Materials and Methods: This is an ongoing unblinded, randomized, controlled pilot trial with two intent-to-treat treatment arms: immediate intensive periodontal therapy or delayed intensive periodontal therapy. The goal of this study was to test the feasibility of conducting this trial among an underserved population (mostly poor and/or low literacy), and to determine the variability of HbA1c levels and albumin/creatinine ratio (A/C%) in response to intensive periodontal therapy over a 4-month period among participants with both CKD and significant periodontal disease. Smoking habits were also reported in a survey taken at baseline.Results: In the treatment group, HbA1c at baseline (6.35%) did not show any difference at 4 months (6.4%) with a change of 0.05. In the control group, HbA1c was virtually the same at baseline (6.68%) and 4 months (6.5%) with a change of -.018. The A/C % ratio for the treatment group at baseline (674.80 mg/g) and at 4 months (639.68 mg/g) showed a change of 167.47. In the control group, the A/C % ratio at baseline (629.40 mg/g) and at 4 months (302.75 mg/g) showed a change of -232.97. Although the changes in A/C % ratio seemed dramatic, their p-values were 0.5625 and 1.000, respectively, indicating no statistical difference. Correlation for smokers could not be performed due to low sample size of 5 subjects in treatment and 2 in control groups.Conclusion: Given the small sample size, this study showed no statistically significant reduction in systemic markers of diabetes as represented by HbA1c or chronic renal disease as represented by albumin/creatinine % ratio. Since this is an ongoing study, when it reaches 51 subjects, there may be a statistically significant improvement in systemic markers of HbA1c and albumin/creatinine % levels. Finally, when all the analysis of the blood samples taken are completed on 51 subjects at 12 months, there will be much more information that can be used to answer the research question.
Subjects/Keywords: Dentistry; Kidney; Periodontitis
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Manager
APA (6th Edition):
Du, D. (2015). Effects of Periodontal Treatment on Diabetes and Chronic Kidney Disease. (Thesis). University of California – San Francisco. Retrieved from http://www.escholarship.org/uc/item/02k290s0
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Du, David. “Effects of Periodontal Treatment on Diabetes and Chronic Kidney Disease.” 2015. Thesis, University of California – San Francisco. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/02k290s0.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Du, David. “Effects of Periodontal Treatment on Diabetes and Chronic Kidney Disease.” 2015. Web. 01 Mar 2021.
Vancouver:
Du D. Effects of Periodontal Treatment on Diabetes and Chronic Kidney Disease. [Internet] [Thesis]. University of California – San Francisco; 2015. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/02k290s0.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Du D. Effects of Periodontal Treatment on Diabetes and Chronic Kidney Disease. [Thesis]. University of California – San Francisco; 2015. Available from: http://www.escholarship.org/uc/item/02k290s0
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Manitoba
15.
Hwang, Sun-Young.
Role of hyperhomocysteinemia in the regulation of oxidative stress and inflammatory responses in the kidney: protective effect of folic acid supplementation.
Degree: Animal Science, 2011, University of Manitoba
URL: http://hdl.handle.net/1993/5066
► Hyperhomocysteinemia, a condition of elevated blood homocysteine (Hcy) level, is an independent risk factor for cardiovascular disease. Folic acid supplementation can effectively reduce blood Hcy…
(more)
▼ Hyperhomocysteinemia, a condition of elevated blood homocysteine (Hcy) level, is an independent risk factor for cardiovascular disease. Folic acid supplementation can effectively reduce blood Hcy levels. Recent studies have demonstrated that hyperhomocysteinemia is also associated with
kidney disease. However, the underlying mechanisms remain unclear. The overall objective of the study was to investigate the biochemical and molecular mechanisms of Hcy-induced
kidney injury and the effect of folic acid supplementation on Hcy-induced
kidney injury.
Hyperhomocysteinemia was induced in Sprague-Dawley rats by feeding a high-methionine diet for 12 weeks. An elevation of serum total Hcy level was observed in hyperhomocysteinemic rats. Hyperhomocysteinemia-induced superoxide anion production via nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation resulted in oxidative stress in the
kidney. Reduction of oxidative stress by inhibiting superoxide anion production effectively ameliorated hyperhomocysteinemia-induced
kidney injury.
Inflammatory responses such as increased chemokine expression have been implicated as one of the mechanisms of
kidney disease. Monocyte chemoattractant protein-1 (MCP-1) is a potent chemokine that is involved in the inflammatory response in
kidney disease. Nuclear factor-kappa B (NF-kappaB) plays an important role in upregulation of MCP-1 expression. We investigated the effect of hyperhomocysteinemia on MCP-1 expression and the molecular mechanism responsible for such an effect in rat kidneys as well as in human
kidney proximal tubular cells.
Advisors/Committee Members: O, Karmin (Animal Science) (supervisor), Guenter, Bill (Animal Science) House, Jamnes (Animal Science) Suh, Miyoung (Human Nutritional Science) (examiningcommittee).
Subjects/Keywords: Homocysteine; Kidney Disease
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Hwang, S. (2011). Role of hyperhomocysteinemia in the regulation of oxidative stress and inflammatory responses in the kidney: protective effect of folic acid supplementation. (Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/5066
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hwang, Sun-Young. “Role of hyperhomocysteinemia in the regulation of oxidative stress and inflammatory responses in the kidney: protective effect of folic acid supplementation.” 2011. Thesis, University of Manitoba. Accessed March 01, 2021.
http://hdl.handle.net/1993/5066.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hwang, Sun-Young. “Role of hyperhomocysteinemia in the regulation of oxidative stress and inflammatory responses in the kidney: protective effect of folic acid supplementation.” 2011. Web. 01 Mar 2021.
Vancouver:
Hwang S. Role of hyperhomocysteinemia in the regulation of oxidative stress and inflammatory responses in the kidney: protective effect of folic acid supplementation. [Internet] [Thesis]. University of Manitoba; 2011. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/1993/5066.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hwang S. Role of hyperhomocysteinemia in the regulation of oxidative stress and inflammatory responses in the kidney: protective effect of folic acid supplementation. [Thesis]. University of Manitoba; 2011. Available from: http://hdl.handle.net/1993/5066
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Manitoba
16.
Choi, Nora.
Study of iron pathophysiology for early diagnosis of acute kidney injury secondary to ischemia reperfusion injury following cardiopulmonary bypass.
Degree: Immunology, 2017, University of Manitoba
URL: http://hdl.handle.net/1993/32763
► Currently, there are no successful therapies proven to ameliorate acute kidney injury (AKI). AKI secondary to ischemia reperfusion injury (IRI) leads to increased morbidity and…
(more)
▼ Currently, there are no successful therapies proven to ameliorate acute
kidney injury (AKI). AKI secondary to ischemia reperfusion injury (IRI) leads to increased morbidity and mortality. The role of iron sequestration throughout cardiac surgery remains unclear, however it may be an important modifier of renal ischemia reperfusion injury. The primary goal was to characterize iron regulatory pathways in a prospective observational cohort of adult cardiac surgery patients in the context of clinical AKI predictors and in relation to clinical prediction alone. The secondary goal was to evaluate potential proteins that may act as non-invasive biomarkers for the early detection of AKI, including urine hepcidin-25, serum ferritin, serum transferrin saturation (TSAT) and urine lactotransferrin. We found that urine hepcidin-25 at postoperative day 1 and serum ferritin and TSAT at 1 hour into cardiopulmonary bypass were independent predictors of AKI avoidance on multivariate analysis, enhancing clinical prediction alone.
Advisors/Committee Members: Ho, Julie (Immunology) (supervisor), HayGlass, Kent (Immunology).
Subjects/Keywords: Acute kidney injury
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APA ·
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to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Choi, N. (2017). Study of iron pathophysiology for early diagnosis of acute kidney injury secondary to ischemia reperfusion injury following cardiopulmonary bypass. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/32763
Chicago Manual of Style (16th Edition):
Choi, Nora. “Study of iron pathophysiology for early diagnosis of acute kidney injury secondary to ischemia reperfusion injury following cardiopulmonary bypass.” 2017. Masters Thesis, University of Manitoba. Accessed March 01, 2021.
http://hdl.handle.net/1993/32763.
MLA Handbook (7th Edition):
Choi, Nora. “Study of iron pathophysiology for early diagnosis of acute kidney injury secondary to ischemia reperfusion injury following cardiopulmonary bypass.” 2017. Web. 01 Mar 2021.
Vancouver:
Choi N. Study of iron pathophysiology for early diagnosis of acute kidney injury secondary to ischemia reperfusion injury following cardiopulmonary bypass. [Internet] [Masters thesis]. University of Manitoba; 2017. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/1993/32763.
Council of Science Editors:
Choi N. Study of iron pathophysiology for early diagnosis of acute kidney injury secondary to ischemia reperfusion injury following cardiopulmonary bypass. [Masters Thesis]. University of Manitoba; 2017. Available from: http://hdl.handle.net/1993/32763
University of Newcastle
17.
Boudville, Neil.
Outcomes following living kidney donation.
Degree: 2018, University of Newcastle
URL: http://hdl.handle.net/1959.13/1385432
► Higher Doctorate - Doctor of Medicine (DMed)
The research that forms the content of this thesis has been performed over the last 14 years and…
(more)
▼ Higher Doctorate - Doctor of Medicine (DMed)
The research that forms the content of this thesis has been performed over the last 14 years and is an ongoing line of research that I am likely to perform for the rest of my career. While a great deal of research has been performed on transplant recipients, it became clear to me 14 years ago that there was limited good research on the outcomes of people who donate their kidneys to people with end-stage kidney disease (except for short-term outcomes in the immediate post-operative period). I subsequently embarked on a research path that commenced with a series of systematic reviews, followed by cross-sectional studies and finally to the commencement of a large prospective observational study to explore in more detail the outcomes of living kidney donors. This dissertation reviews my research to date, with the large prospective study still years away from completion. My research efforts have not included commercial donors, who likely have quite different outcomes. There are a number of important patient-level outcomes that I have explored and so I have divided this thesis into chapters based upon groups of these outcomes. Within the chapters I follow a primarily temporal order for my research and describe some other key publications from other research groups.
Advisors/Committee Members: University of Newcastle. Faculty of Health & Medicine, School of Medicine and Public Health.
Subjects/Keywords: chronic kidney disease; kidney transplantation; living kidney transplantation; living donor
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APA (6th Edition):
Boudville, N. (2018). Outcomes following living kidney donation. (Thesis). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/1385432
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Boudville, Neil. “Outcomes following living kidney donation.” 2018. Thesis, University of Newcastle. Accessed March 01, 2021.
http://hdl.handle.net/1959.13/1385432.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Boudville, Neil. “Outcomes following living kidney donation.” 2018. Web. 01 Mar 2021.
Vancouver:
Boudville N. Outcomes following living kidney donation. [Internet] [Thesis]. University of Newcastle; 2018. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/1959.13/1385432.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Boudville N. Outcomes following living kidney donation. [Thesis]. University of Newcastle; 2018. Available from: http://hdl.handle.net/1959.13/1385432
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Western Ontario
18.
Naylor, Kyla L.
Epidemiology of Fracture in Adults with Kidney Disease.
Degree: 2015, University of Western Ontario
URL: https://ir.lib.uwo.ca/etd/3003
► Fractures are a global health concern, leading to morbidity and mortality. Individuals with reduced kidney function experience bone mineral metabolism changes which can increase fracture…
(more)
▼ Fractures are a global health concern, leading to morbidity and mortality. Individuals with reduced kidney function experience bone mineral metabolism changes which can increase fracture risk. Yet, there is little consensus on the fundamentals: prediction, incidence, risk factors, and screening of fractures in kidney disease patients. This thesis addressed these critical areas helping decrease the health burden of fracture in this unique population.
This research used data from the Canadian Multicentre Osteoporosis Study (CaMos) to examine individuals with chronic kidney disease (CKD) (n=320). CaMos is a national longitudinal study designed to collect information on fractures. To examine kidney transplant recipients data from Ontario administrative healthcare databases was used (n=4821). The predictive ability of the Fracture Risk Assessment Tool (FRAX) in individuals with CKD was evaluated using area under the receiver operator characteristic curves and survival analyses. The incidence and risk factors for fracture in kidney transplant recipients were assessed using incidence rates and Cox hazard regression analysis.
The first manuscript systematically summarized the incidence and risk factors for fracture in kidney transplant recipients; fracture incidence and risk factors were variable across studies.
The second manuscript examined the predictive value of FRAX in individuals with CKD compared to individuals with normal kidney function. The discriminative ability of FRAX for fracture prediction was comparable in both groups.
The third manuscript examined the incidence of fracture in kidney transplant recipients. The cumulative incidence of fracture was low with approximately 2% sustaining a hip fracture over 10-years.
The fourth manuscript examined risk factors for fracture in kidney transplant recipients. Transplant-specific risk factors (i.e., diabetes or cystic kidney disease as the cause of end-stage renal disease and donor age) and general risk factors (i.e., older recipient age and female sex) were significantly associated with fractures.
The fifth manuscript examined the frequency and variability in bone mineral density (BMD) testing across Ontario transplant centres. Over half of kidney transplant recipients received at least one BMD and the ordering of BMD tests varied widely by centre – from 15% to 92%.
Results can be used to improve prognostication, advance clinical guidelines, clarify fracture incidence, and guide informed consent.
Subjects/Keywords: fracture; kidney disease; chronic kidney disease; kidney transplant recipient; epidemiology; bone; Epidemiology
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APA (6th Edition):
Naylor, K. L. (2015). Epidemiology of Fracture in Adults with Kidney Disease. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/3003
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Naylor, Kyla L. “Epidemiology of Fracture in Adults with Kidney Disease.” 2015. Thesis, University of Western Ontario. Accessed March 01, 2021.
https://ir.lib.uwo.ca/etd/3003.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Naylor, Kyla L. “Epidemiology of Fracture in Adults with Kidney Disease.” 2015. Web. 01 Mar 2021.
Vancouver:
Naylor KL. Epidemiology of Fracture in Adults with Kidney Disease. [Internet] [Thesis]. University of Western Ontario; 2015. [cited 2021 Mar 01].
Available from: https://ir.lib.uwo.ca/etd/3003.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Naylor KL. Epidemiology of Fracture in Adults with Kidney Disease. [Thesis]. University of Western Ontario; 2015. Available from: https://ir.lib.uwo.ca/etd/3003
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Sydney
19.
Hanson, Camilla Sara.
Improving Access and Outcomes in Living Kidney Donor Transplantation
.
Degree: 2017, University of Sydney
URL: http://hdl.handle.net/2123/17370
► Shortages in deceased organ donation have necessitated widespread acceptance of living donor kidney transplantation, which offers better outcomes in terms of graft survival, life expectancy…
(more)
▼ Shortages in deceased organ donation have necessitated widespread acceptance of living donor kidney transplantation, which offers better outcomes in terms of graft survival, life expectancy and quality of life for many patients with end-stage kidney disease, compared with deceased donor kidney transplantation and dialysis. However, there are barriers and challenges that exist in the current practice of living kidney donor transplantation. Overall, the rates of living kidney donor transplantation have decreased or plateaued, with ethic and socio-economic disparities in access to living kidney donation reported in many countries that remain largely unexplained. Living donors must accept risks associated with undergoing nephrectomy, yet the evidence on the long-term risks of living kidney donation remains uncertain. In response, there have been efforts to identify and describe the barriers and disparities in living kidney donor transplantation, improve the pathway for living donors and to assess a range of outcomes for living donors. A comprehensive understanding of the values, beliefs, experiences, priorities and preferences of the key stakeholders, including donors and health professionals involved in their care is needed to ensure that research; clinical practice and policy in living kidney donation address their needs and priorities. This is a thesis by publication containing published and submitted work. The aims of the studies included in this thesis are: 1) To identify and describe the beliefs, attitudes and expectations of patients with CKD regarding living kidney donation. 2) To describe kidney donors’ experiences of the evaluation process, and the motivations and challenges to sustaining commitment prior to donation. 3) To describe nephrologists’ perspectives on barriers to living kidney donation and disparities in access to living kidney donor transplantation. 4) To identify living kidney donors’ priorities for outcomes and describe the reasons for their choices. 5) To determine the characteristics and heterogeneity of outcomes reported in randomised trials and observational studies in adult living kidney donors
Subjects/Keywords: Kidney disease;
kidney transplant;
living kidney donor;
qualitative;
nominal group technique;
outcomes
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Manager
APA (6th Edition):
Hanson, C. S. (2017). Improving Access and Outcomes in Living Kidney Donor Transplantation
. (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/17370
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hanson, Camilla Sara. “Improving Access and Outcomes in Living Kidney Donor Transplantation
.” 2017. Thesis, University of Sydney. Accessed March 01, 2021.
http://hdl.handle.net/2123/17370.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hanson, Camilla Sara. “Improving Access and Outcomes in Living Kidney Donor Transplantation
.” 2017. Web. 01 Mar 2021.
Vancouver:
Hanson CS. Improving Access and Outcomes in Living Kidney Donor Transplantation
. [Internet] [Thesis]. University of Sydney; 2017. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/2123/17370.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hanson CS. Improving Access and Outcomes in Living Kidney Donor Transplantation
. [Thesis]. University of Sydney; 2017. Available from: http://hdl.handle.net/2123/17370
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Otago
20.
Nejat, Maryam.
Biomarkers in early diagnosis of acute kidney injury
.
Degree: 2011, University of Otago
URL: http://hdl.handle.net/10523/1915
► Acute Kidney injury (AKI) is common and frequently fatal. Delay in plasma creatinine based diagnosis of AKI has compromised clinical trials of experimentally promising therapies…
(more)
▼ Acute
Kidney injury (AKI) is common and frequently fatal. Delay in plasma creatinine based diagnosis of AKI has compromised clinical trials of experimentally promising therapies of
kidney injury. Therefore, a number of potential early urinary and plasma biomarkers of renal cell injury have been evaluated in several clinical and experimental studies. However, many uncertainties remain in the diagnostic and predictive capability of these biomarkers in various forms of AKI, especially in heterogeneous population.
The overall aim in this project was to analyse the diagnostic and predictive performance of some novel AKI biomarkers in a heterogeneous high-risk population. This project focused on the performance of plasma and urinary cystatin C (CysC) as markers of
kidney function and injury respectively and both as predictors of mortality. This involved separate analysis of plasma and urinary CysC clinical data, and an experimental study investigating the performance of urinary CysC in the presence of albuminuria. Finally, the ability of fractional urinary biomarkers (fractional excretion of sodium (FENa) and urea (FEurea) to distinguish between so-called pre-renal AKI and established AKI was assessed.
Clinical data came from the EARLYARF study, which was initiated by Professor Zoltan Endre prior to commencement of my PhD project. I participated in data collection and data entry for the large part of this study and I was provided access to the database to address the objectives of my thesis. The hypotheses were explored by analysing data arising from this study. The experimental study of the effect of proteinuria and albuminuria on urinary CysC arose from the observation of cystatinuria in children with proteinuria. This was explored in an animal model of transient albuminuria, which I developed.
Plasma CysC has been proposed as an alternative to plasma creatinine as a measure of renal function. In Chapter 3, relative changes of plasma CysC and plasma creatinine were compared in critically ill patients. I was able to demonstrate that plasma CysC generally increased prior to plasma creatinine. Plasma CysC and creatinine were similarly moderately predictive of death or the need for dialysis. Plasma CysC was a more effective and earlier surrogate marker of decreased renal function than plasma creatinine in a general intensive care unit population.
In Chapter 4, the utility of urinary CysC as a diagnostic marker of AKI, and predictor of mortality in critically ill patients was evaluated. Urinary CysC was diagnostic of and predictive of death. Unexpectedly, it was also found to be diagnostic of sepsis. Concentrations of urinary CysC were significantly higher in the presence of sepsis (p<0.0001) or AKI (p<0.0001). There was no interaction between sepsis and AKI on the urinary CysC concentrations (p=0.53). Urinary CysC was independently associated with AKI, sepsis, and death within 30 days.
Low molecular weight (LMW) proteins, including albumin and novel urinary biomarkers of AKI such as CysC and neutrophil…
Advisors/Committee Members: Endre, Zoltan Huba (advisor).
Subjects/Keywords: Acute kidney injury;
Biomarkers
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APA (6th Edition):
Nejat, M. (2011). Biomarkers in early diagnosis of acute kidney injury
. (Doctoral Dissertation). University of Otago. Retrieved from http://hdl.handle.net/10523/1915
Chicago Manual of Style (16th Edition):
Nejat, Maryam. “Biomarkers in early diagnosis of acute kidney injury
.” 2011. Doctoral Dissertation, University of Otago. Accessed March 01, 2021.
http://hdl.handle.net/10523/1915.
MLA Handbook (7th Edition):
Nejat, Maryam. “Biomarkers in early diagnosis of acute kidney injury
.” 2011. Web. 01 Mar 2021.
Vancouver:
Nejat M. Biomarkers in early diagnosis of acute kidney injury
. [Internet] [Doctoral dissertation]. University of Otago; 2011. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/10523/1915.
Council of Science Editors:
Nejat M. Biomarkers in early diagnosis of acute kidney injury
. [Doctoral Dissertation]. University of Otago; 2011. Available from: http://hdl.handle.net/10523/1915
21.
Antonio Gomes da Silva Neto.
Estudo dos efeitos vasculares e renais causados pelo 6-gingerol isolado do gengibre.
Degree: Master, 2012, Universidade Federal do Ceará
URL: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=11522
;
► O gengibre possui em sua composiÃÃo inÃmeras substÃncias volÃteis e nÃo volÃteis. Dentre as substÃncias nÃo-volÃteis destacam-se, principalmente, os gingerols, sendo o 6-gingerol o composto…
(more)
▼ O gengibre possui em sua composiÃÃo inÃmeras substÃncias volÃteis e nÃo volÃteis. Dentre as substÃncias nÃo-volÃteis destacam-se, principalmente, os gingerols, sendo o 6-gingerol o composto mais abundante e o responsÃvel pela grande maioria das atividades farmacolÃgicas descritas, como a anti-hipertensiva. Neste trabalho, foram investigados os efeitos renais, vasculares e em cultura de cÃlulas tubulares renais do tipo MDCK (Madin-Darby Canine
Kidney) causados pelo 6-gingerol. Foram utilizados ratos Wistar machos pesando entre 250 e 300g, cujos rins foram isolados e perfundidos com SoluÃÃo de Krebs-Hanseleit contendo 6%p/v de albumina bovina previamente dialisada. Foram investigados os efeitos do 6-gingerol (3 μM, 10 μM, 30 μM; n=6) sobre a PressÃo de PerfusÃo (PP), ResistÃncia Vascular Renal (RVR), Fluxo UrinÃrio (FU), Ritmo de FiltraÃÃo Glomerular (RFG), Percentual de Transporte Tubular de SÃdio (%TNa+), de PotÃssio (%TK+) e de Cloreto (%TCl-). O 6-gingerol foi adicionado apÃs 30 minutos de controle interno. As cÃlulas MDCK foram cultivadas em meio de cultura RPMI 1640 suplementado com 10% v/v de Soro Bovino Fetal e entÃo avaliadas na presenÃa do composto em diversas concentraÃÃes em dois perÃodos de incubaÃÃo, 6 (seis) e 24 (vinte e quatro) horas. ApÃs esses perÃodos, foram realizados ensaios de viabilidade celular. Foi avaliada a resposta do 6-gingerol em diversas concentraÃÃes na pressÃo arterial mÃdia de ratos wistar normotensos anestesiados. Os resultados encontrados na pressÃo arterial dos animais foi uma queda acentuada de maneira dose-dependente na pressÃo arterial destes animais. Em relaÃÃo à perfusÃo renal, o 6-gingerol mostrou-se um potente diurÃtico e com baixÃssimos danos renais tanto nos dados encontrados no perfil histolÃgico, como nos experimentos de avaliaÃÃo de viabilidade celular em cÃlulas MDCK o que està em consonÃncia com o conhecimento da medicina tradicional.
Os resultados encontrados nÃo foram totalmente abolidos pelo inibidor especÃfico do receptor TRPV1 utilizado no estudo, demonstrando que o 6-gingerol possui outras vias renais a serem exploradas em estudos posteriores.
Advisors/Committee Members: Helena Serra Azul Monteiro, Renata de Sousa Alves, Alexandre Havt BindÃ.
Subjects/Keywords: FARMACOLOGIA; Gengibre; Rim; Ginger; Kidney
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APA (6th Edition):
Neto, A. G. d. S. (2012). Estudo dos efeitos vasculares e renais causados pelo 6-gingerol isolado do gengibre. (Masters Thesis). Universidade Federal do Ceará. Retrieved from http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=11522 ;
Chicago Manual of Style (16th Edition):
Neto, Antonio Gomes da Silva. “Estudo dos efeitos vasculares e renais causados pelo 6-gingerol isolado do gengibre.” 2012. Masters Thesis, Universidade Federal do Ceará. Accessed March 01, 2021.
http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=11522 ;.
MLA Handbook (7th Edition):
Neto, Antonio Gomes da Silva. “Estudo dos efeitos vasculares e renais causados pelo 6-gingerol isolado do gengibre.” 2012. Web. 01 Mar 2021.
Vancouver:
Neto AGdS. Estudo dos efeitos vasculares e renais causados pelo 6-gingerol isolado do gengibre. [Internet] [Masters thesis]. Universidade Federal do Ceará 2012. [cited 2021 Mar 01].
Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=11522 ;.
Council of Science Editors:
Neto AGdS. Estudo dos efeitos vasculares e renais causados pelo 6-gingerol isolado do gengibre. [Masters Thesis]. Universidade Federal do Ceará 2012. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=11522 ;
Universiteit Utrecht
22.
Verhoek, J.H.P.
Hyperaldosteronism: The Prevalence and Role in Cats with Chronic Kidney Disease.
Degree: 2010, Universiteit Utrecht
URL: http://dspace.library.uu.nl:8080/handle/1874/272875
► Introduction- The zona glomerulosa of the adrenal glands produces aldosterone. In primary hyperaldosteronism there is an aldosterone excess due to an adrenocortical tumor or a…
(more)
▼ Introduction- The zona glomerulosa of the adrenal glands produces aldosterone. In primary hyperaldosteronism there is an aldosterone excess due to an adrenocortical tumor or a non-tumoral adrenocortical hyperplasia. A mineralocorticoid excess causes increased sodium retention and an increased potassium excretion. This can lead to muscle weakness or paralysis and acute blindness by ablatio retinae or intraocular bleeding. It is also associated with slowly progressive renal failure.
Aim of the study- The aim of the research is to demonstrate that hyperaldosteronism is more common among cats than is assumed and to investigate the prevalence of primary hyperaldosteronism in cats with chronic renal failure. When the disease is diagnosed in an early stage a treatment can be started and the renal damage may be limited.
Hypothesis- The prevalence of primary hyperaldosteronism in cats with chronic
kidney disease is approximately 10%.
Animals- Twenty-one cats kept as companion animal have been examined for this study. After measuring creatinine and thyroxine levels, seven of the twenty-one cats could not be taken into account in the study because of a creatinine level within the reference range (indicating no renal failure is present) or thyroxine levels above the upper reference value (indicating a possible thyroid problem). Therefore fourteen cats were suitable for measurement of plasma aldosterone concentration (PAC) and plasma renin concentration (PRA).
Methods- Blood pressure measurements, blood and urine collection and analysis and eye examinations were performed on the cats.
Results- There were no significant correlations found. Eight of the cats had a blood pressure >160 mmHg. In six cases the plasma potassium concentration was below the reference values, six cats had an aldosterone-renin ratio above the reference values. The specific gravity of the urine was below the reference values in six cats and in two cats retinal abnormalities were found.
Conclusion- Given the limited number of cats examined, no firm conclusions can be drawn. It is necessary to obtain more data in order to determine the prevalence of primary hyperaldosteronism in cats with chronic
kidney disease. However, six out of fourteen cats had an aldosterone-renin ratio above the reference value and may have primary hyperaldosteronism.
Advisors/Committee Members: Kooistra, H.S..
Subjects/Keywords: Diergeneeskunde; hyperaldosteronism, cat, kidney
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APA (6th Edition):
Verhoek, J. H. P. (2010). Hyperaldosteronism: The Prevalence and Role in Cats with Chronic Kidney Disease. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/272875
Chicago Manual of Style (16th Edition):
Verhoek, J H P. “Hyperaldosteronism: The Prevalence and Role in Cats with Chronic Kidney Disease.” 2010. Doctoral Dissertation, Universiteit Utrecht. Accessed March 01, 2021.
http://dspace.library.uu.nl:8080/handle/1874/272875.
MLA Handbook (7th Edition):
Verhoek, J H P. “Hyperaldosteronism: The Prevalence and Role in Cats with Chronic Kidney Disease.” 2010. Web. 01 Mar 2021.
Vancouver:
Verhoek JHP. Hyperaldosteronism: The Prevalence and Role in Cats with Chronic Kidney Disease. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2010. [cited 2021 Mar 01].
Available from: http://dspace.library.uu.nl:8080/handle/1874/272875.
Council of Science Editors:
Verhoek JHP. Hyperaldosteronism: The Prevalence and Role in Cats with Chronic Kidney Disease. [Doctoral Dissertation]. Universiteit Utrecht; 2010. Available from: http://dspace.library.uu.nl:8080/handle/1874/272875
Universiteit Utrecht
23.
Hoek, G. van de.
Identifying novel genes involved in congenital anomalies of the kidney and urinary tract.
Degree: 2013, Universiteit Utrecht
URL: http://dspace.library.uu.nl:8080/handle/1874/287149
► The recent collation of a large patient cohort encompassing the complete CAKUT spectrum, the advent of next generation sequencing (NGS) and progress in bioinformatic developmental…
(more)
▼ The recent collation of a large patient cohort encompassing the complete CAKUT spectrum, the advent of next generation sequencing (NGS) and progress in bioinformatic developmental gene network modeling have created the opportunity to identify novel genetic causes, characterize complex genotype-phenotype relationships and develop rapid and reliable gene diagnostic tools for CAKUT. The studies on CAKUT genetics will have important implications for affected patients and their families. The elucidation of the complex genetics of disease transmission through studies of exome-wide genetic variability will pave the way towards individualized and more effective genetic counseling of families affected by CAKUT.
Advisors/Committee Members: Renkema, K.
Subjects/Keywords: Kidney disease; next generation sequencing
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APA (6th Edition):
Hoek, G. v. d. (2013). Identifying novel genes involved in congenital anomalies of the kidney and urinary tract. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/287149
Chicago Manual of Style (16th Edition):
Hoek, G van de. “Identifying novel genes involved in congenital anomalies of the kidney and urinary tract.” 2013. Masters Thesis, Universiteit Utrecht. Accessed March 01, 2021.
http://dspace.library.uu.nl:8080/handle/1874/287149.
MLA Handbook (7th Edition):
Hoek, G van de. “Identifying novel genes involved in congenital anomalies of the kidney and urinary tract.” 2013. Web. 01 Mar 2021.
Vancouver:
Hoek Gvd. Identifying novel genes involved in congenital anomalies of the kidney and urinary tract. [Internet] [Masters thesis]. Universiteit Utrecht; 2013. [cited 2021 Mar 01].
Available from: http://dspace.library.uu.nl:8080/handle/1874/287149.
Council of Science Editors:
Hoek Gvd. Identifying novel genes involved in congenital anomalies of the kidney and urinary tract. [Masters Thesis]. Universiteit Utrecht; 2013. Available from: http://dspace.library.uu.nl:8080/handle/1874/287149
Oregon State University
24.
Lee, Yun-hwa.
[8-¹⁴C]zeatin metabolism in Phaseolus embryos.
Degree: MS, Horticulture, 1984, Oregon State University
URL: http://hdl.handle.net/1957/25533
Subjects/Keywords: Kidney bean
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APA (6th Edition):
Lee, Y. (1984). [8-¹⁴C]zeatin metabolism in Phaseolus embryos. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/25533
Chicago Manual of Style (16th Edition):
Lee, Yun-hwa. “[8-¹⁴C]zeatin metabolism in Phaseolus embryos.” 1984. Masters Thesis, Oregon State University. Accessed March 01, 2021.
http://hdl.handle.net/1957/25533.
MLA Handbook (7th Edition):
Lee, Yun-hwa. “[8-¹⁴C]zeatin metabolism in Phaseolus embryos.” 1984. Web. 01 Mar 2021.
Vancouver:
Lee Y. [8-¹⁴C]zeatin metabolism in Phaseolus embryos. [Internet] [Masters thesis]. Oregon State University; 1984. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/1957/25533.
Council of Science Editors:
Lee Y. [8-¹⁴C]zeatin metabolism in Phaseolus embryos. [Masters Thesis]. Oregon State University; 1984. Available from: http://hdl.handle.net/1957/25533
25.
Uchiyama, Takanobu; Takata, Shunsuke; Ishikawa, Hiroyuki.
Altered dynamics in the renal lymphatic circulation of type 1 and type 2 diabetic mice. : Altered dynamics in the renal lymphatic circulation of type 1 and type 2 diabetic mice.
Degree: 博士（歯学）, 2014, Fukuoka Dental College / 福岡歯科大学
URL: http://id.nii.ac.jp/1167/00000009/
► The dynamics of the renal lymphatic circulation in diabetic nephropathy is not fully elucidated. The present study evaluated the effect of diabetic nephropathy on the…
(more)
▼ The dynamics of the renal lymphatic circulation in diabetic nephropathy is not fully elucidated. The present study evaluated the effect of diabetic nephropathy on the renal lymphatic circulation in streptozotocin (STZ)-induced type 1 diabetic mice (ICR-STZ) and in type 2 diabetic KK/Ta mice which were fed a high fat diet (KK/Ta-HF). The diabetic mouse kidneys developed edema because of the nephropathy. In control mice renal lymphatic vessels distributed in the cortex but rarely in the medulla while in ICR-STZ and KK/Ta-HF mice, there were many lymphatic vessels with small lumen in both cortex and medulla. Total numbers and areas of renal blood vessels in the diabetic mice were similar to those in the controls while the total numbers and areas of renal lymphatic vessels were larger in diabetic mice than in the controls. There were statistically significant differences in the numbers of lymphatic vessels with diameters of 50-100 µm between the ICR-STZ and the control ICR mice, and in the numbers of lymphatic capillaries with diameters smaller than 50 µm between the KK/Ta-HF and the control KK/Ta mice. The diabetic nephropathy may induce the lymphangiogenesis or result in at least the renal lymphatic vessel expansion.
2013年度
Subjects/Keywords: diabetes; kidney; lymphangiogenesis; lymphatics; nephropathy
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APA (6th Edition):
Uchiyama, Takanobu; Takata, Shunsuke; Ishikawa, H. (2014). Altered dynamics in the renal lymphatic circulation of type 1 and type 2 diabetic mice. : Altered dynamics in the renal lymphatic circulation of type 1 and type 2 diabetic mice. (Thesis). Fukuoka Dental College / 福岡歯科大学. Retrieved from http://id.nii.ac.jp/1167/00000009/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Uchiyama, Takanobu; Takata, Shunsuke; Ishikawa, Hiroyuki. “Altered dynamics in the renal lymphatic circulation of type 1 and type 2 diabetic mice. : Altered dynamics in the renal lymphatic circulation of type 1 and type 2 diabetic mice.” 2014. Thesis, Fukuoka Dental College / 福岡歯科大学. Accessed March 01, 2021.
http://id.nii.ac.jp/1167/00000009/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Uchiyama, Takanobu; Takata, Shunsuke; Ishikawa, Hiroyuki. “Altered dynamics in the renal lymphatic circulation of type 1 and type 2 diabetic mice. : Altered dynamics in the renal lymphatic circulation of type 1 and type 2 diabetic mice.” 2014. Web. 01 Mar 2021.
Vancouver:
Uchiyama, Takanobu; Takata, Shunsuke; Ishikawa H. Altered dynamics in the renal lymphatic circulation of type 1 and type 2 diabetic mice. : Altered dynamics in the renal lymphatic circulation of type 1 and type 2 diabetic mice. [Internet] [Thesis]. Fukuoka Dental College / 福岡歯科大学; 2014. [cited 2021 Mar 01].
Available from: http://id.nii.ac.jp/1167/00000009/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Uchiyama, Takanobu; Takata, Shunsuke; Ishikawa H. Altered dynamics in the renal lymphatic circulation of type 1 and type 2 diabetic mice. : Altered dynamics in the renal lymphatic circulation of type 1 and type 2 diabetic mice. [Thesis]. Fukuoka Dental College / 福岡歯科大学; 2014. Available from: http://id.nii.ac.jp/1167/00000009/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Mississippi State University
26.
Grant, Joshua.
The development of a model for vascular calcification and the effects of magnesium supplementation on <i>in vitro</i> calcification.
Degree: MS, Agricultural and Biological Engineering, 2015, Mississippi State University
URL: http://sun.library.msstate.edu/ETD-db/theses/available/etd-10292015-215744/
;
► Cardiovascular disease is most deadly medical condition in the United States. Medial vascular calcification is a disease that often precedes other more serious cardiovascular…
(more)
▼ Cardiovascular disease is most deadly medical condition in the United States. Medial vascular calcification is a disease that often precedes other more serious cardiovascular diseases that have high mortality. In order to research new therapies for the treatment of medial vascular calcification, an <i>in vitro</i> cell culture model must be developed that mimics the process <i>in vivo</i>. This disease is shown to be an active, cell-mediated process where the vascular smooth muscle cells (VSMCs) in the arteries are differentiating into osteoblast-like cells and depositing hydroxyapatite mineral in the artery walls. By administering inorganic phosphate to cell culture medium, an osteogenic shift can initiated in VSMCs <i>in vitro</i> resulting in calcium deposition and an increase in bone related proteins. We propose to develop and characterize a model for vascular calcification and investigate the effects of magnesium supplementation on <i>in vitro</i> calcification and cellular phosphate uptake.
Advisors/Committee Members: Chartrisa LaShan Simpson (chair), Jun Liao (committee member), George Eli Howell III (committee member), Steven H. Elder (committee member).
Subjects/Keywords: Chronic Kidney Disease; Osteogenic Differentiation
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APA (6th Edition):
Grant, J. (2015). The development of a model for vascular calcification and the effects of magnesium supplementation on <i>in vitro</i> calcification. (Masters Thesis). Mississippi State University. Retrieved from http://sun.library.msstate.edu/ETD-db/theses/available/etd-10292015-215744/ ;
Chicago Manual of Style (16th Edition):
Grant, Joshua. “The development of a model for vascular calcification and the effects of magnesium supplementation on <i>in vitro</i> calcification.” 2015. Masters Thesis, Mississippi State University. Accessed March 01, 2021.
http://sun.library.msstate.edu/ETD-db/theses/available/etd-10292015-215744/ ;.
MLA Handbook (7th Edition):
Grant, Joshua. “The development of a model for vascular calcification and the effects of magnesium supplementation on <i>in vitro</i> calcification.” 2015. Web. 01 Mar 2021.
Vancouver:
Grant J. The development of a model for vascular calcification and the effects of magnesium supplementation on <i>in vitro</i> calcification. [Internet] [Masters thesis]. Mississippi State University; 2015. [cited 2021 Mar 01].
Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-10292015-215744/ ;.
Council of Science Editors:
Grant J. The development of a model for vascular calcification and the effects of magnesium supplementation on <i>in vitro</i> calcification. [Masters Thesis]. Mississippi State University; 2015. Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-10292015-215744/ ;
University of Alberta
27.
Desai, Prajakta V.
Deciphering the Claudins that Mediate Renal Calcium
Reabsorption.
Degree: MS, Medical Sciences-Paediatrics, 2012, University of Alberta
URL: https://era.library.ualberta.ca/files/7s75dd66w
► Kidney stones and osteoporosis are prevalent clinical conditions posing a large economic burden to the healthcare system. A common risk factor for both these diseases…
(more)
▼ Kidney stones and osteoporosis are prevalent clinical
conditions posing a large economic burden to the healthcare system.
A common risk factor for both these diseases is hypercalciuria,
which is the inappropriate excretion of calcium in urine. Changes
in serum calcium levels are detected by the calcium sensing
receptor (CaSR). In the kidney, the CaSR is localized in tubular
segments where calcium (Ca2+) flux occurs via the paracellular
pathway, specifically the proximal tubule and the thick ascending
limb of Henle’s loop (TAL). Claudins are proteins localized in the
tight junction of epithelia that control paracellular ion flux.
Recently, claudin-14 (Cldn14) expression was observed in the TAL.
We found that Cldn14 is regulated by dietary Ca2+ intake and by
elevated serum Ca2+ levels after prolonged 1,25-dihydroxyvitamin D3
administration in mice. Consistent with this, in vivo activation of
the CaSR by administration of the calcimimetic Cinacalcet, lead to
a 40-fold increase in Cldn14 mRNA abundance. Overexpression of
Cldn14 in a renal tubular cell culture model inhibited paracellular
Ca2+ flux. Together the data suggests that when serum Ca2+ level
increases it activates the CaSR leading to increased Cldn14
expression in the TAL. This in turn blocks Ca2+ reabsorption and
induces calciuria. Dysregulation of this newly described
CaSR-Cldn14 axis likely contributes to the development of
hypercalciuria and kidney stones.
Subjects/Keywords: Kidney Stones; Osteoporosis; Claudins; Calcium
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APA (6th Edition):
Desai, P. V. (2012). Deciphering the Claudins that Mediate Renal Calcium
Reabsorption. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/7s75dd66w
Chicago Manual of Style (16th Edition):
Desai, Prajakta V. “Deciphering the Claudins that Mediate Renal Calcium
Reabsorption.” 2012. Masters Thesis, University of Alberta. Accessed March 01, 2021.
https://era.library.ualberta.ca/files/7s75dd66w.
MLA Handbook (7th Edition):
Desai, Prajakta V. “Deciphering the Claudins that Mediate Renal Calcium
Reabsorption.” 2012. Web. 01 Mar 2021.
Vancouver:
Desai PV. Deciphering the Claudins that Mediate Renal Calcium
Reabsorption. [Internet] [Masters thesis]. University of Alberta; 2012. [cited 2021 Mar 01].
Available from: https://era.library.ualberta.ca/files/7s75dd66w.
Council of Science Editors:
Desai PV. Deciphering the Claudins that Mediate Renal Calcium
Reabsorption. [Masters Thesis]. University of Alberta; 2012. Available from: https://era.library.ualberta.ca/files/7s75dd66w
University of Alberta
28.
Chow, Aaron K.Y.
A novel mouse model of acute antibody-mediated transplant
rejection shows simultaneous complement activating and
anti-inflammatory effects of donor specific IgG antibodies.
Degree: MS, Medical Sciences- Laboratory Medicine and
Pathology, 2013, University of Alberta
URL: https://era.library.ualberta.ca/files/ht24wk73f
► We developed a small animal model of pure antibody-mediated rejection (ABMR) by utilizing fully major histocompatibility complex (MHC) mismatched kidney allografts in mice. By examining…
(more)
▼ We developed a small animal model of pure
antibody-mediated rejection (ABMR) by utilizing fully major
histocompatibility complex (MHC) mismatched kidney allografts in
mice. By examining resultant ABMR pathology, we show that terminal
complement products C5a and C5b-9 are crucial in establishing
antibody-mediated allograft microvascular and tubular injury, and
the presence of proximal complement product C4d alone is not
indicative of ABMR. We demonstrate allorecognition capabilities in
NK cells to induce micro-inflammation and apoptosis in MHC
mismatched transplants. By gene expression profiling, we found that
binding of donor specific antibodies (DSA) into kidney allograft
tissues induces a ‘self-protective’ anti-inflammatory response in
kidney parenchyma. The data suggests that the anti-inflammatory
response associated with DSA may be regulated via inhibitory Fc
receptors for immunoglobulin G. In summary, we established a mouse
model demonstrating pure acute ABMR of kidney allografts mimicking
some aspects of human ABMR pathology in the absence of T
cell-mediated rejection.
Subjects/Keywords: Transplantation; Antibody; Rejection; Kidney
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APA ·
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MLA ·
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Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Chow, A. K. Y. (2013). A novel mouse model of acute antibody-mediated transplant
rejection shows simultaneous complement activating and
anti-inflammatory effects of donor specific IgG antibodies. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/ht24wk73f
Chicago Manual of Style (16th Edition):
Chow, Aaron K Y. “A novel mouse model of acute antibody-mediated transplant
rejection shows simultaneous complement activating and
anti-inflammatory effects of donor specific IgG antibodies.” 2013. Masters Thesis, University of Alberta. Accessed March 01, 2021.
https://era.library.ualberta.ca/files/ht24wk73f.
MLA Handbook (7th Edition):
Chow, Aaron K Y. “A novel mouse model of acute antibody-mediated transplant
rejection shows simultaneous complement activating and
anti-inflammatory effects of donor specific IgG antibodies.” 2013. Web. 01 Mar 2021.
Vancouver:
Chow AKY. A novel mouse model of acute antibody-mediated transplant
rejection shows simultaneous complement activating and
anti-inflammatory effects of donor specific IgG antibodies. [Internet] [Masters thesis]. University of Alberta; 2013. [cited 2021 Mar 01].
Available from: https://era.library.ualberta.ca/files/ht24wk73f.
Council of Science Editors:
Chow AKY. A novel mouse model of acute antibody-mediated transplant
rejection shows simultaneous complement activating and
anti-inflammatory effects of donor specific IgG antibodies. [Masters Thesis]. University of Alberta; 2013. Available from: https://era.library.ualberta.ca/files/ht24wk73f
Oregon State University
29.
Biuk, Abdulmajid Ahmed.
Physiological and yield responses of snap beans (Phaseolus vulgaris) to water availability.
Degree: PhD, Soil Science, 1982, Oregon State University
URL: http://hdl.handle.net/1957/42025
Subjects/Keywords: Kidney bean
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APA (6th Edition):
Biuk, A. A. (1982). Physiological and yield responses of snap beans (Phaseolus vulgaris) to water availability. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/42025
Chicago Manual of Style (16th Edition):
Biuk, Abdulmajid Ahmed. “Physiological and yield responses of snap beans (Phaseolus vulgaris) to water availability.” 1982. Doctoral Dissertation, Oregon State University. Accessed March 01, 2021.
http://hdl.handle.net/1957/42025.
MLA Handbook (7th Edition):
Biuk, Abdulmajid Ahmed. “Physiological and yield responses of snap beans (Phaseolus vulgaris) to water availability.” 1982. Web. 01 Mar 2021.
Vancouver:
Biuk AA. Physiological and yield responses of snap beans (Phaseolus vulgaris) to water availability. [Internet] [Doctoral dissertation]. Oregon State University; 1982. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/1957/42025.
Council of Science Editors:
Biuk AA. Physiological and yield responses of snap beans (Phaseolus vulgaris) to water availability. [Doctoral Dissertation]. Oregon State University; 1982. Available from: http://hdl.handle.net/1957/42025
Oregon State University
30.
Sader, Rubens.
Effect of N and P fertilizers on growth, nitrate reductase activity, seed production and seed quality of snap bean (Phaseolus vulgaris L.).
Degree: PhD, Crop Science, 1979, Oregon State University
URL: http://hdl.handle.net/1957/42775
Subjects/Keywords: Kidney bean
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APA ·
Chicago ·
MLA ·
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Export
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Manager
APA (6th Edition):
Sader, R. (1979). Effect of N and P fertilizers on growth, nitrate reductase activity, seed production and seed quality of snap bean (Phaseolus vulgaris L.). (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/42775
Chicago Manual of Style (16th Edition):
Sader, Rubens. “Effect of N and P fertilizers on growth, nitrate reductase activity, seed production and seed quality of snap bean (Phaseolus vulgaris L.).” 1979. Doctoral Dissertation, Oregon State University. Accessed March 01, 2021.
http://hdl.handle.net/1957/42775.
MLA Handbook (7th Edition):
Sader, Rubens. “Effect of N and P fertilizers on growth, nitrate reductase activity, seed production and seed quality of snap bean (Phaseolus vulgaris L.).” 1979. Web. 01 Mar 2021.
Vancouver:
Sader R. Effect of N and P fertilizers on growth, nitrate reductase activity, seed production and seed quality of snap bean (Phaseolus vulgaris L.). [Internet] [Doctoral dissertation]. Oregon State University; 1979. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/1957/42775.
Council of Science Editors:
Sader R. Effect of N and P fertilizers on growth, nitrate reductase activity, seed production and seed quality of snap bean (Phaseolus vulgaris L.). [Doctoral Dissertation]. Oregon State University; 1979. Available from: http://hdl.handle.net/1957/42775
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Open Access Theses and Dissertations
