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University of Manitoba

1. Dyck, Allison. Increased GFAP in motor cortex and bimanual coordination deficits in a rat (Rattus Norvegicus) model of repeated pediatric mild traumatic brain injury.

Degree: Psychology, 2018, University of Manitoba

Brain injury induces brain change, which is modulated by sex and developmental age. We examined brain change in juvenile rats after repeated mild brain traumatic injuries. We hypothesized the rat pups would show graded deficits in behavioural performance and a graded increase in protein expression, both increasing with the number of impacts. Three-week-old rats received 1-3 concussions over three days, compared to sham controls without concussive impact. The wire-hanging task revealed a dose-like effect of injury, with performance worsening with the addition of each injury. Glial acidic protein level was highest in the two-injury group. Corticosterone was significantly different for sex and injury status, without an interaction. Our findings suggest repetitive concussion causes rapid changes in motor behaviour and the brain in juvenile rats. Even mild brain injuries require care and attention to avoid repeated injuries and an increase to long-lasting brain disruption. Advisors/Committee Members: Ivanco, Tammy (Psychology) (supervisor), Marotta, Jonathan (Psychology) (examiningcommittee), Glazebrook, Cheryl (Kinesiology and Recreation Management) (examiningcommittee).

Subjects/Keywords: Plasticity; rat; juvenile; mTBI; concussion; Inflammation; GFAP; CORT

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APA (6th Edition):

Dyck, A. (2018). Increased GFAP in motor cortex and bimanual coordination deficits in a rat (Rattus Norvegicus) model of repeated pediatric mild traumatic brain injury. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/33356

Chicago Manual of Style (16th Edition):

Dyck, Allison. “Increased GFAP in motor cortex and bimanual coordination deficits in a rat (Rattus Norvegicus) model of repeated pediatric mild traumatic brain injury.” 2018. Masters Thesis, University of Manitoba. Accessed June 20, 2019. http://hdl.handle.net/1993/33356.

MLA Handbook (7th Edition):

Dyck, Allison. “Increased GFAP in motor cortex and bimanual coordination deficits in a rat (Rattus Norvegicus) model of repeated pediatric mild traumatic brain injury.” 2018. Web. 20 Jun 2019.

Vancouver:

Dyck A. Increased GFAP in motor cortex and bimanual coordination deficits in a rat (Rattus Norvegicus) model of repeated pediatric mild traumatic brain injury. [Internet] [Masters thesis]. University of Manitoba; 2018. [cited 2019 Jun 20]. Available from: http://hdl.handle.net/1993/33356.

Council of Science Editors:

Dyck A. Increased GFAP in motor cortex and bimanual coordination deficits in a rat (Rattus Norvegicus) model of repeated pediatric mild traumatic brain injury. [Masters Thesis]. University of Manitoba; 2018. Available from: http://hdl.handle.net/1993/33356

2. Kovac Renata. Uticaj subhroničnog tretmana akrilamidom na histološke i biohemijske karakteristike jetre juvenilnih mužjaka pacova.

Degree: 2016, University of Novi Sad

Akrilamid (CASR No. 79-06-1) predstavlja veoma reaktivni, hidrosolubilni monomer za koji se smatra da ima toksične i potencijalno kancerogene efekte po zdravlje ljudi. Štetne posledice akrilamida i njegovog još reaktivnijeg metabolita, glicidamida, su dokazane kod eksperimentalnih životinja i podrazumevale su neurotoksičnost, genotoksičnost i kancerogenost. Epidemiološke studije rađene na ljudima pokazale su da akrilamid izaziva neurotoksične efekte, dok se genotoksičnost i kancerogenost još smatraju potencijalnim efektima, a zasnivaju se na podacima koji su dobijeni u okviru istraživanja na laboratorijskim životinjama. Njegove štetne posledice na jetru, posebno kod mladog organizma, još uvek nisu dovoljno istražene. Akrilamid se spontano formira u hrani koja je bogata ugljenim hidratima, tokom termičke obrade namirnica na visokim temperaturama. Ovaj monomer se formira tokom tzv. neenzimatske Mallard-ove reakcije, kojom se dobijaju smeđe komponente u hrani. U namirnicama ovaj monomer se formira reakcijom između redukujućih šećera (uglavnom glukoze ili fruktoze) i aminokiseline (dominantno asparagina). Imajući na umu da je jetra centralni organ za metabolizam akrilamida, ovo istraživanje  je imalo za cilj da ispita glavne histološke i biohemijske promene na jetri juvenilnog organizma pacova, nakon njegove subhronične ekspozicije akrilamidu. Istraživanje je  rađeno na 3 eksperimentalne grupe peripubertalnih/juvenilnih mužjaka Wistar pacova, od kojih su dve bile tretirane vodenim rastvorom akrilamida u dozi od 25 ili 50  mg/kg telesne mase, dok je treća grupa služila kao kontrola i primala destilovanu vodu. Životinje su bile tretirane oralno, putem gavaže, 5 dana nedeljno, tokom 3 nedelje. Nakon 24 h od poslednjeg tretmana, životinje su uvedene u etarsku  anesteziju i dekapitovane, a zatim su prikupljeni krv i uzorci tkiva jetre. Tkivo jetre je uzeto iz srednjeg lobusa, fiksirano u 10% neutralnom puferisanom  formalinu tokom 24 h i obrađeno prema standardnom protokolu za parafinsko kalupljenje. Ukalupljeni uzorci jetre su zatim isečeni na serijske preseke tkiva debljine 5 µm, a zatim bojeni histohemijskim i imunohistohemijskim metodama. Uzorci krvi su pripremljeni za serološku analizu.  Histološka analiza preseka bojenih hematoksilin-eozin (H&E) metodom nije  zabeležila prisustvo značajnih razlika u opštoj arhitekturi jetre i njenoj lobularnoj  organizaciji među eksperimentalnim grupama. Stereološka analiza je ukazala na   mikrostrukturne promene kod hepatocita i jetrinih sinusoida. Rezultati sugerišu, na dozno-zavisno povećanje volumena hepatocita, njihove citoplazme i nukleusa, i doznozavsino smanjenje volumena sinusoida, u odnosu na kontrolne uzorke jetre. Analiza glikogena je rađena na presecima jetre bojenim metodom Periodic… Advisors/Committee Members: Matavulj Milica, Đolai Matilda, Ušćebrka Gordana.

Subjects/Keywords: akrilamid, subhronični tretman, jetra, juvenilni pacovi, histohemija, imunohistohemija, serološke analize; acrylamide, subchronic treatment, liver, juvenile rat, histochemistry, immunohistochemistry, biochemical analiysis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Renata, K. (2016). Uticaj subhroničnog tretmana akrilamidom na histološke i biohemijske karakteristike jetre juvenilnih mužjaka pacova. (Thesis). University of Novi Sad. Retrieved from http://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija146040209268033.pdf?controlNumber=(BISIS)100604&fileName=146040209268033.pdf&id=5326&source=OATD&language=en ; http://www.cris.uns.ac.rs/record.jsf?recordId=100604&source=OATD&language=en

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Renata, Kovac. “Uticaj subhroničnog tretmana akrilamidom na histološke i biohemijske karakteristike jetre juvenilnih mužjaka pacova.” 2016. Thesis, University of Novi Sad. Accessed June 20, 2019. http://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija146040209268033.pdf?controlNumber=(BISIS)100604&fileName=146040209268033.pdf&id=5326&source=OATD&language=en ; http://www.cris.uns.ac.rs/record.jsf?recordId=100604&source=OATD&language=en.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Renata, Kovac. “Uticaj subhroničnog tretmana akrilamidom na histološke i biohemijske karakteristike jetre juvenilnih mužjaka pacova.” 2016. Web. 20 Jun 2019.

Vancouver:

Renata K. Uticaj subhroničnog tretmana akrilamidom na histološke i biohemijske karakteristike jetre juvenilnih mužjaka pacova. [Internet] [Thesis]. University of Novi Sad; 2016. [cited 2019 Jun 20]. Available from: http://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija146040209268033.pdf?controlNumber=(BISIS)100604&fileName=146040209268033.pdf&id=5326&source=OATD&language=en ; http://www.cris.uns.ac.rs/record.jsf?recordId=100604&source=OATD&language=en.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Renata K. Uticaj subhroničnog tretmana akrilamidom na histološke i biohemijske karakteristike jetre juvenilnih mužjaka pacova. [Thesis]. University of Novi Sad; 2016. Available from: http://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija146040209268033.pdf?controlNumber=(BISIS)100604&fileName=146040209268033.pdf&id=5326&source=OATD&language=en ; http://www.cris.uns.ac.rs/record.jsf?recordId=100604&source=OATD&language=en

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


EPFL

3. Perin, Rodrigo de Campos. Emergent Dynamics in Neocortical Microcircuits.

Degree: 2010, EPFL

Interactions among neurons can take place in a wide variety of forms. It is the goal of this thesis to investigate the properties and implications of a number of these interactions that we believe are relevant for information processing in the brain. Neuroscience has progressed considerably in identifying the diverse neuronal cell-types and providing detailed information about their individual morphological, genetic and electrophysiological properties. It remains a great challenge to identify how this diversity of cells interacts at the microcircuit level. This task is made more complex by the fact that the forms of interaction are not always obvious or simple to observe, even with advanced scientific equipment. In order to achieve a better understanding and envision possible implications of the concerted activity of multiple neurons, experiments and models must often be used jointly and iteratively. In this thesis I first present the development of a computer-assisted system for multi-electrode patch-clamp that enabled new kinds of experiments, allowing qualitatively different information to be obtained concerning the interaction of multiple neurons. In the following chapters I describe the different questions addressed and approaches utilized in the investigation of neuronal interactions using multi-electrode patch-clamp experiments. The principles behind the clustered organization of synaptic connectivity in Layer V of the somatosensory cortex are the first experimental finding presented. I then quantify the ephaptic coupling between neurons and how apparently minute signals might help correlate the activity of many neurons. Next, the ubiquity of a neocortical microcircuit responsible for frequency-dependent disynaptic inhibition is demonstrated and the summation properties of this microcircuit are then analyzed. Finally a model to explain the interactions between gap junctions and synaptic transmission in the olfactory bulb is proposed. Advisors/Committee Members: Markram, Henry.

Subjects/Keywords: neocortical microcircuitry; somatosensory cortex; juvenile rat; in vitro electrophysiology; multi-electrode; patch-clamp recording; synapse; gap junction; connectivity; clustering; plasticity; ephaptic; extracellular field; excitation; frequency-dependent disynaptic inhibition; acute brain slices; pyramidal cell; Martinotti cell; microcircuit néocortical; cortex somatosensoriel; rat juvénile; électrophysiologie in-vitro; multi-électrodes; enregistrement patch-clamp; synapse; gap junction; regroupement; plasticité; ephaptique; champ extracellulaire; excitation; inhibition disynaptique fréquence-dépendante; section de cerveau; cellule pyramidale; cellule de Martinotti

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Perin, R. d. C. (2010). Emergent Dynamics in Neocortical Microcircuits. (Thesis). EPFL. Retrieved from http://infoscience.epfl.ch/record/147975

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Perin, Rodrigo de Campos. “Emergent Dynamics in Neocortical Microcircuits.” 2010. Thesis, EPFL. Accessed June 20, 2019. http://infoscience.epfl.ch/record/147975.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Perin, Rodrigo de Campos. “Emergent Dynamics in Neocortical Microcircuits.” 2010. Web. 20 Jun 2019.

Vancouver:

Perin RdC. Emergent Dynamics in Neocortical Microcircuits. [Internet] [Thesis]. EPFL; 2010. [cited 2019 Jun 20]. Available from: http://infoscience.epfl.ch/record/147975.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Perin RdC. Emergent Dynamics in Neocortical Microcircuits. [Thesis]. EPFL; 2010. Available from: http://infoscience.epfl.ch/record/147975

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.