subject:(isoflurane)

Dalhousie University

1. Wood, Leah M. REGULATION OF RETINAL ACTIVITY IN AN EX-VIVO GUINEA PIG MODEL BY EXPERIMENTAL CONDITIONS AND EFFECTS OF ISOFLURANE AND PROPOFOL ANESTHETICS.

Degree: MS, Department of Clinical Vision Science, 2011, Dalhousie University

URL: http://hdl.handle.net/10222/13187

► Electroretinoraphic signals (ERGs) are affected when recorded under isoflurane anesthesia in the operating room. We explored the effect of isoflurane and propofol in ex vivo… (more)

Subjects/Keywords: electroretinogram; isoflurane; propofol; multielectrode array; retinal activity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wood, L. M. (2011). REGULATION OF RETINAL ACTIVITY IN AN EX-VIVO GUINEA PIG MODEL BY EXPERIMENTAL CONDITIONS AND EFFECTS OF ISOFLURANE AND PROPOFOL ANESTHETICS. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/13187

Chicago Manual of Style (16^th Edition):

Wood, Leah M. “REGULATION OF RETINAL ACTIVITY IN AN EX-VIVO GUINEA PIG MODEL BY EXPERIMENTAL CONDITIONS AND EFFECTS OF ISOFLURANE AND PROPOFOL ANESTHETICS.” 2011. Masters Thesis, Dalhousie University. Accessed January 18, 2021. http://hdl.handle.net/10222/13187.

MLA Handbook (7^th Edition):

Wood, Leah M. “REGULATION OF RETINAL ACTIVITY IN AN EX-VIVO GUINEA PIG MODEL BY EXPERIMENTAL CONDITIONS AND EFFECTS OF ISOFLURANE AND PROPOFOL ANESTHETICS.” 2011. Web. 18 Jan 2021.

Vancouver:

Wood LM. REGULATION OF RETINAL ACTIVITY IN AN EX-VIVO GUINEA PIG MODEL BY EXPERIMENTAL CONDITIONS AND EFFECTS OF ISOFLURANE AND PROPOFOL ANESTHETICS. [Internet] [Masters thesis]. Dalhousie University; 2011. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10222/13187.

Council of Science Editors:

Wood LM. REGULATION OF RETINAL ACTIVITY IN AN EX-VIVO GUINEA PIG MODEL BY EXPERIMENTAL CONDITIONS AND EFFECTS OF ISOFLURANE AND PROPOFOL ANESTHETICS. [Masters Thesis]. Dalhousie University; 2011. Available from: http://hdl.handle.net/10222/13187

University of Guelph

2. Gianotti, Giacomo. ASSESSMENT OF THE EFFECT OF PRIOR NOXIOUS STIMULATION ON MINIMUM ALVEOLAR CONCENTRATION DETERMINATIONS IN THE DOG AND RABBIT.

Degree: Doctor of Veterinary Science, Department of Clinical Studies, 2012, University of Guelph

URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3247

► This thesis determines and compares the sparing effect of ketamine on the minimum alveolar concentration (MAC) of isoflurane in rabbits and dogs using two methods… (more)

▼ This thesis determines and compares the sparing effect of ketamine on the minimum alveolar concentration (MAC) of isoflurane in rabbits and dogs using two methods in a crossover random design. One method determined the MAC of isoflurane and ketamine combined after previous determination of the MAC of isoflurane during the same day. The second method determined the MAC for the combination without prior determination of the MAC of isoflurane. The concentration of ketamine and norketamine in plasma were also determined in dogs. For the first method, the MAC of isoflurane in rabbits was 2.15 ± 0.09% (mean ± SD) and decreased to 1.63 ± 0.07% during ketamine administration (1 mg/kg bolus and a constant rate infusion [CRI] of 40 µg/kg/min). In dogs, the same ketamine dose decreased the MAC of isoflurane from 1.18 ± 0.14% to 0.88 ± 0.14%. Re-determination of MAC of isoflurane performed after stopping the CRI yielded a MAC value of 2.04 ± 0.11% in rabbits and of 1.09 ± 0.16% in dogs. MAC values of the isoflurane and ketamine combination determined for the second method were 1.53 ± 0.22% in rabbits and 0.79 ± 0.11% in dogs. MAC values of isoflurane after stopping the CRI of ketamine were 1.94 ± 0.25% in rabbits and 1.10 ± 0.17% in dogs. The MAC value obtained in dogs for the isoflurane and ketamine combination with the first method was significantly higher with respect to the MAC value obtained with the second method (0.88 ± 0.14 versus 0.79 ± 0.11%); whereas in rabbits, MAC values were similar. During ketamine administration in dogs, plasma concentrations of ketamine at MAC values were similar for the first and second method (824 ± 195.7 ng/mL and 729 ± 133.4 ng/mL, respectively). After stopping the CRI, plasma concentrations during isoflurane MAC were also similar for the two methods (407 ± 176.2 ng/mL and 347 ± 81.2 ng/mL, respectively). MAC values for the isoflurane and ketamine combination obtained with both methods were statistically different in dogs but not in rabbits, however these findings may be the result of the design of the study and tolerable experimental error derived from MAC studies rather than true species differences. Advisors/Committee Members: Valverde, Alexander (advisor).

Subjects/Keywords: MAC; Anesthesia; ketamine; isoflurane; dog; rabbit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gianotti, G. (2012). ASSESSMENT OF THE EFFECT OF PRIOR NOXIOUS STIMULATION ON MINIMUM ALVEOLAR CONCENTRATION DETERMINATIONS IN THE DOG AND RABBIT. (Doctoral Dissertation). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3247

Chicago Manual of Style (16^th Edition):

Gianotti, Giacomo. “ASSESSMENT OF THE EFFECT OF PRIOR NOXIOUS STIMULATION ON MINIMUM ALVEOLAR CONCENTRATION DETERMINATIONS IN THE DOG AND RABBIT.” 2012. Doctoral Dissertation, University of Guelph. Accessed January 18, 2021. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3247.

MLA Handbook (7^th Edition):

Gianotti, Giacomo. “ASSESSMENT OF THE EFFECT OF PRIOR NOXIOUS STIMULATION ON MINIMUM ALVEOLAR CONCENTRATION DETERMINATIONS IN THE DOG AND RABBIT.” 2012. Web. 18 Jan 2021.

Vancouver:

Gianotti G. ASSESSMENT OF THE EFFECT OF PRIOR NOXIOUS STIMULATION ON MINIMUM ALVEOLAR CONCENTRATION DETERMINATIONS IN THE DOG AND RABBIT. [Internet] [Doctoral dissertation]. University of Guelph; 2012. [cited 2021 Jan 18]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3247.

Council of Science Editors:

Gianotti G. ASSESSMENT OF THE EFFECT OF PRIOR NOXIOUS STIMULATION ON MINIMUM ALVEOLAR CONCENTRATION DETERMINATIONS IN THE DOG AND RABBIT. [Doctoral Dissertation]. University of Guelph; 2012. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3247

University of Guelph

3. Uccello, Olivia. Cardiovascular Effects of Increasing Doses of Norepinephrine in Healthy Isoflurane-Anesthetized New Zealand White Rabbits.

Degree: MS, Department of Clinical Studies, 2020, University of Guelph

URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/17756

► Profound decreases in blood pressure occurs in anesthetized rabbits. Norepinephrine (NE) is a potent vasoconstrictor and inotrope, used to treat hypotension in multiple species; however,… (more)

Subjects/Keywords: Norepinephrine; Anesthesia; Isoflurane; Hypotension; Rabbits; Sympathomimetics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Uccello, O. (2020). Cardiovascular Effects of Increasing Doses of Norepinephrine in Healthy Isoflurane-Anesthetized New Zealand White Rabbits. (Masters Thesis). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/17756

Chicago Manual of Style (16^th Edition):

Uccello, Olivia. “Cardiovascular Effects of Increasing Doses of Norepinephrine in Healthy Isoflurane-Anesthetized New Zealand White Rabbits.” 2020. Masters Thesis, University of Guelph. Accessed January 18, 2021. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/17756.

MLA Handbook (7^th Edition):

Uccello, Olivia. “Cardiovascular Effects of Increasing Doses of Norepinephrine in Healthy Isoflurane-Anesthetized New Zealand White Rabbits.” 2020. Web. 18 Jan 2021.

Vancouver:

Uccello O. Cardiovascular Effects of Increasing Doses of Norepinephrine in Healthy Isoflurane-Anesthetized New Zealand White Rabbits. [Internet] [Masters thesis]. University of Guelph; 2020. [cited 2021 Jan 18]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/17756.

Council of Science Editors:

Uccello O. Cardiovascular Effects of Increasing Doses of Norepinephrine in Healthy Isoflurane-Anesthetized New Zealand White Rabbits. [Masters Thesis]. University of Guelph; 2020. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/17756

University of Texas Southwestern Medical Center

4. Mantravadi, Vasudha. Isoflurane Preserves Viability of Highly Metabolic Renal Epithelial Cells Exposed to Anoxia.

Degree: 2016, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/7075

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The general metadata – e.g., title, author, abstract, subject headings, etc. – is publicly available, but access to the submitted files is restricted to UT… (more)

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The general metadata – e.g., title, author, abstract, subject headings, etc. – is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.

BACKGROUND: Cells subjected to ischemia, whether in the context of hypoxia, hypovolemia, or circulatory collapse, undergo damage and death as a result of oxygen deprivation. Previous studies have shown that general anesthetics can protect cells from ischemic injury by lowering their aerobic metabolism and decreasing production of toxic metabolites, among other mechanisms (1, 2, 3). This very preliminary study investigated the potential protective effect of isoflurane on the survival of cells that have a fairly high baseline metabolic rate, human renal proximal tubular epithelial cells (HK-2) and human microvascular endothelial cells (HMEC), in an anoxic environment. METHODS: Cultured HK-2 and HMEC cells were incubated in a Forma Scientific Anaerobic System at 37C either in the absence (control) or presence (experimental) of 5% isoflurane for 0, 24, 48, 72, and 96 hours. Cell viability and metabolic activity were then assessed using live/dead fluorescence imaging and an MTT cell metabolism assay, respectively. RESULTS: In vitro exposure of cells to anoxia without isoflurane over a period of 96 hours, resulted in a reduction of viability of HK-2 cells from a baseline of 98%, to approximately 8-9%. Over the same period of time, viability of cells exposed to isoflurane and anoxia decreased to 35%. This represented a fourfold increase in survival of HK-2 cells exposed to isoflurane at 96 hours. At earlier time points, both cell death in anoxia, and the protective effect of isoflurane were less dramatic. HMECs did not undergo significant cell death upon exposure to either anoxia or anoxia with isoflurane, with 98% of the cells surviving the exposure to anoxia in both cases. The net metabolic activity, as assessed by absorbance using the MTT assay, decreased in HK-2 cells over increasing periods of anoxia, a trend that did not change with the addition of isoflurane. Metabolic activity of HMECs remained intact and relatively stable throughout the course of anoxic exposure. CONCLUSION: In this preliminary study, continuous exposure of HK-2 cells to 5% isoflurane during anoxic incubation had a protective effect on cell viability over a period of 96 hours. Whether this effect was also present in the less metabolically active HMECs, was not determined, as anoxia over the time period of the study had little effect on cell viability in either the experimental group or in the control group. The protective effect observed for HK-2 cells will likely vary with differences in metabolic requirements of different cell types, types and concentrations of anesthetic agents, and duration of anesthetic exposure. Anesthetic treatment may need to be tailored specifically to a cell type to confer the protective effects desired.

Advisors/Committee Members: Kojima, Koji, Ambardekar, Aditee, Lin, Xihui, Gingrich, Kevin.

Subjects/Keywords: Epithelial Cells; Hypoxia; Isoflurane; Kidney Tubules, Proximal

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mantravadi, V. (2016). Isoflurane Preserves Viability of Highly Metabolic Renal Epithelial Cells Exposed to Anoxia. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/7075

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mantravadi, Vasudha. “Isoflurane Preserves Viability of Highly Metabolic Renal Epithelial Cells Exposed to Anoxia.” 2016. Thesis, University of Texas Southwestern Medical Center. Accessed January 18, 2021. http://hdl.handle.net/2152.5/7075.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mantravadi, Vasudha. “Isoflurane Preserves Viability of Highly Metabolic Renal Epithelial Cells Exposed to Anoxia.” 2016. Web. 18 Jan 2021.

Vancouver:

Mantravadi V. Isoflurane Preserves Viability of Highly Metabolic Renal Epithelial Cells Exposed to Anoxia. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2016. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2152.5/7075.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mantravadi V. Isoflurane Preserves Viability of Highly Metabolic Renal Epithelial Cells Exposed to Anoxia. [Thesis]. University of Texas Southwestern Medical Center; 2016. Available from: http://hdl.handle.net/2152.5/7075

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

5. Païta, Lucille. Caractérisation du canal cationique TRPV1 dans les cardiomyocytes : Implication of TRPV1 in cardioprotection during ischemia reperfusion.

Degree: Docteur es, Cardiologie, 2016, Lyon

URL: http://www.theses.fr/2016LYSE1329

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L'infarctus du myocarde, une des causes majeures de mortalité à travers le monde, engendre une mort irréversible du muscle cardiaque suite à une ischémie. Cette… (more)

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L'infarctus du myocarde, une des causes majeures de mortalité à travers le monde, engendre une mort irréversible du muscle cardiaque suite à une ischémie. Cette ischémie, c'est-à-dire une privation de dioxygène et de nutriments, déclencher un stress réticulaire qui perturbe l'équilibre calcique de la cellule cardiaque. Plusieurs pompes et canaux calciques situés à la membrane plasmique ou réticulaire sont des intervenants clés dans le maintien de l'homéostasie calcique. Parmi eux, il existe des canaux de fuites calciques passives, comme les TRPs, et peu d'informations sont actuellement connus à propos de leur rôle précis au cours de l'infarctus du myocarde.TRPV1 est un canal cationique non sélectif qui est activé par la capsaïcine, le pH et la chaleur nocive (>42°C). Dans le muscle squelettique, nous avions démontré que TRPV1 est situé dans la partie longitudinale du réticulum sarcoplasmique et qu'il répond à différentes stimulations physiologiques et pharmacologiques (Lotteau et al., 2013). Ici, nous nous interrogeons sur un éventuel rôle similaire de TRPV1 dans la physiologie cardiaque. Des analyses biochimiques et des mesures de calcium intracellulaire furent réalisées sur des cardiomyocytes issus de souris WT et KO TRPV1. Nos résultats in vitro montrent que: (a) TRPV1 est exprimé dans les cellules cardiaques; (b) une activation de TRPV1 engendre une réduction de la concentration calcique réticulaire et que (c) TRPV1 pourrait être une cible directe de l'isoflurane.Dans la mesure où TRPV1 peut être modulé par de nombreuses molécules pharmacologiques, il pourrait constituer une cible thérapeutique pour réduire la taille d'infarctus. De nombreuses études antérieures ont déjà mis en évidence un rôle cardioprotecteur de TRPV1 dans le système nerveux entourant le cœur. Le but de cette étude est de décrire le fonctionnement des canaux TRPV1 dans des cardiomyocytes adultes

Acute myocardial infarction (MI), a leading cause of morbidity and mortality worldwide, is the irreversible death of heart muscle secondary to ischemia. This ischemia, i.e. oxygen and nutrients deprivation, triggers a reticular stress disrupting the Ca2+ balance of the cardiac cell. Several Ca2+ pumps and channels located at the sarcolemma or at the reticulum membrane are key players in this maintenance of Ca2+ homeostasis. Among them, we find passive leak channels, such as TRPs and little is known about their precise role in MI.TRPV1 represents a non-selective cation channel that is activated by capsaicin, pH and noxious heat. In skeletal muscle, we previously demonstrated that TRPV1 is located in the longitudinal part of the SR and respond to pharmacological and physiological activations (Lotteau et al., 2013). We questioned here whether TRPV1 might have a similar role in heart physiology. Biochemical analysis and intracellular Ca2+ measurements were performed on cardiomyocytes from wild-type and TRPV1-KO mice. Our in vitro results show that: (i) TRPV1 is expressed in cardiac cells; (ii) an increase in intracellular calcium concentration ([Ca2+]i)…

Advisors/Committee Members: Van Coppenolle, Fabien (thesis director), Ducreux, Sylvie (thesis director).

Subjects/Keywords: Coeur; TRPV1; Infarctus; Isoflurane; Cardiomyocytes; Calcium; Heart; TRPV1; Myocardial infarction; Isoflurane; Cardiomyocytes; Calcium; 571

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Païta, L. (2016). Caractérisation du canal cationique TRPV1 dans les cardiomyocytes : Implication of TRPV1 in cardioprotection during ischemia reperfusion. (Doctoral Dissertation). Lyon. Retrieved from http://www.theses.fr/2016LYSE1329

Chicago Manual of Style (16^th Edition):

Païta, Lucille. “Caractérisation du canal cationique TRPV1 dans les cardiomyocytes : Implication of TRPV1 in cardioprotection during ischemia reperfusion.” 2016. Doctoral Dissertation, Lyon. Accessed January 18, 2021. http://www.theses.fr/2016LYSE1329.

MLA Handbook (7^th Edition):

Païta, Lucille. “Caractérisation du canal cationique TRPV1 dans les cardiomyocytes : Implication of TRPV1 in cardioprotection during ischemia reperfusion.” 2016. Web. 18 Jan 2021.

Vancouver:

Païta L. Caractérisation du canal cationique TRPV1 dans les cardiomyocytes : Implication of TRPV1 in cardioprotection during ischemia reperfusion. [Internet] [Doctoral dissertation]. Lyon; 2016. [cited 2021 Jan 18]. Available from: http://www.theses.fr/2016LYSE1329.

Council of Science Editors:

Païta L. Caractérisation du canal cationique TRPV1 dans les cardiomyocytes : Implication of TRPV1 in cardioprotection during ischemia reperfusion. [Doctoral Dissertation]. Lyon; 2016. Available from: http://www.theses.fr/2016LYSE1329

University of British Columbia

6. Miu, Peter. Isoflurane induced impairment of synaptic transmission in hippocampal neurons of the guinea pig in vitro.

Degree: MS- MSc, Pharmacology, 1988, University of British Columbia

URL: http://hdl.handle.net/2429/28027

► The effects of anaesthetic applications of isoflurane on 82 CA₁ neurons were studied in in vitro preparations (guinea pigs) using intracellular recording techniques. Various parameters… (more)

Subjects/Keywords: Isoflurane; Neurons; Neural transmission; Isoflurane; Neurons – physiology; Synaptic Transmission

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Miu, P. (1988). Isoflurane induced impairment of synaptic transmission in hippocampal neurons of the guinea pig in vitro. (Masters Thesis). University of British Columbia. Retrieved from http://hdl.handle.net/2429/28027

Chicago Manual of Style (16^th Edition):

Miu, Peter. “Isoflurane induced impairment of synaptic transmission in hippocampal neurons of the guinea pig in vitro.” 1988. Masters Thesis, University of British Columbia. Accessed January 18, 2021. http://hdl.handle.net/2429/28027.

MLA Handbook (7^th Edition):

Miu, Peter. “Isoflurane induced impairment of synaptic transmission in hippocampal neurons of the guinea pig in vitro.” 1988. Web. 18 Jan 2021.

Vancouver:

Miu P. Isoflurane induced impairment of synaptic transmission in hippocampal neurons of the guinea pig in vitro. [Internet] [Masters thesis]. University of British Columbia; 1988. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2429/28027.

Council of Science Editors:

Miu P. Isoflurane induced impairment of synaptic transmission in hippocampal neurons of the guinea pig in vitro. [Masters Thesis]. University of British Columbia; 1988. Available from: http://hdl.handle.net/2429/28027

University of Rochester

7. Smith, Charles Owen. KNa1.2 as a Cardiac Mitochondrial Potassium Channel with Metabolic Impact on Energy Usage.

Degree: PhD, 2020, University of Rochester

URL: http://hdl.handle.net/1802/35807

► Mitochondrial respiration is critical for meeting the energy demand of metabolically active tissues. As such, these tissues are especially sensitive to the cessation of oxygen… (more)

▼ Mitochondrial respiration is critical for meeting the energy demand of metabolically active tissues. As such, these tissues are especially sensitive to the cessation of oxygen and substrate delivery, referred to as ischemia. Cardiac ischemia, or heart attack, is the major cause of mortality and morbidity in the US. Mitochondria have been shown to be central arbiters of ischemic damage and cell death, and our lab focuses on identifying molecular pathways that mediate protection. Within this context, several K+ channels thought to be located in the mitochondrial inner membrane have been hypothesized to be necessary for this mitochondrial impact on ischemia. Additionally activation of mitochondrial K+ channels is thought to be sufficient to protect against ischemic and subsequent reperfusion injury. The focus of this thesis is the Na+-activated K+ channel K Na1.2 and its physiologic role in mitochondria. Here, utilizing a genetically-manipulated mouse model that lacks KNa1.2 (gene: Kcnt2), together with patch-clamp electrophysiology of mitochondrial membranes, biophysical assays of purified mitochondria and ex vivo cardiac Langendorff perfusions, I provide evidence that 1) KNa1.2 is essential for cardioprotection triggered by volatile anesthetics, 2) KNa1.2 encodes a bona fide mitochondrial channel that alters membrane conductances, and 3) KNa1.2 plays a role in cardiac physiology whereby opening regulates fuel substrate selection. Of particular note, I find that channels matching the pharmacologic and biophysical properties of KNa1.2 can be found in WT but not Kcnt2-/- patches, and that a novel metabolic phenotype is observed in Kcnt2-/- mice. Specifically, mitochondria from these mice are characterized by a reduced ability to respond to increases in energetic demand when restricted to fatty acid oxidation. In conclusion, I hypothesize that KNa1.2 is a molecular rheostat that couples energetic demand to substrate utilization through regulating K+ permeability of the mitochondrial membrane.

Subjects/Keywords: Mitochondria; Slo2.1; Slick; KNA1.2; Patch clamp; Cardioprotection; Isoflurane

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Smith, C. O. (2020). KNa1.2 as a Cardiac Mitochondrial Potassium Channel with Metabolic Impact on Energy Usage. (Doctoral Dissertation). University of Rochester. Retrieved from http://hdl.handle.net/1802/35807

Chicago Manual of Style (16^th Edition):

Smith, Charles Owen. “KNa1.2 as a Cardiac Mitochondrial Potassium Channel with Metabolic Impact on Energy Usage.” 2020. Doctoral Dissertation, University of Rochester. Accessed January 18, 2021. http://hdl.handle.net/1802/35807.

MLA Handbook (7^th Edition):

Smith, Charles Owen. “KNa1.2 as a Cardiac Mitochondrial Potassium Channel with Metabolic Impact on Energy Usage.” 2020. Web. 18 Jan 2021.

Vancouver:

Smith CO. KNa1.2 as a Cardiac Mitochondrial Potassium Channel with Metabolic Impact on Energy Usage. [Internet] [Doctoral dissertation]. University of Rochester; 2020. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1802/35807.

Council of Science Editors:

Smith CO. KNa1.2 as a Cardiac Mitochondrial Potassium Channel with Metabolic Impact on Energy Usage. [Doctoral Dissertation]. University of Rochester; 2020. Available from: http://hdl.handle.net/1802/35807

University of Guelph

8. Keating, Stephanie. The cardiopulmonary effects and pharmacokinetics of fentanyl in the dog: The influence of isoflurane anesthesia and sedative administration during anesthetic recovery.

Degree: Doctor of Veterinary Science, Department of Clinical Studies, 2013, University of Guelph

URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/6548

► The objectives of this study were to determine the cardiopulmonary effects and pharmacokinetics of fentanyl in dogs during isoflurane anesthesia and during anesthetic recovery with… (more)

▼ The objectives of this study were to determine the cardiopulmonary effects and pharmacokinetics of fentanyl in dogs during isoflurane anesthesia and during anesthetic recovery with or without dexmedetomidine or acepromazine sedation. This was investigated in 7 healthy dogs using a randomized cross over study design. Dogs were given fentanyl as an initial IV loading dose (5 μg/kg) followed by an infusion (5 μg/kg/hr) for 120 minutes during isoflurane anesthesia and for 60 minutes following isoflurane discontinuation. Dogs received IV dexmedetomidine (2.5 μg/kg), acepromazine (0.05 mg/kg) or saline at the time of isoflurane discontinuation. Cardiopulmonary variables were measured and blood samples were obtained at multiple time points during the anesthetic maintenance and recovery phases. Plasma concentrations of fentanyl were measured using HPLC-MS, and subsequent population pharmacokinetic analysis was performed. During isoflurane anesthesia, fentanyl bolus administration resulted in significant changes in measured cardiopulmonary variables, however, many returned to baseline values during the maintenance of anesthesia. During anesthetic recovery, dexmedetomidine administration resulted in significant increases in PaCO2, and decreases in PvO2 and CI. Systemic arterial blood pressures were significantly lower in dogs receiving acepromazine, however CI and PvO2 were significantly higher compared to the other treatments. Analysis of fentanyl plasma concentrations showed that fentanyl pharmacokinetics best fit a 2-compartmental model, with average concentrations in the treatment groups ranging from 1.6 to 4.5 ng/mL during isoflurane anesthesia, and from 1.6 to 2.0 ng/mL during anesthetic recovery. Plasma concentrations of fentanyl were significantly higher with dexmedetomidine administration compared to the other treatments during the recovery period. Compared to the maintenance phase of anesthesia, anesthetic recovery with dexmedetomidine administration did not significantly change fentanyl pharmacokinetics, while acepromazine administration increased systemic and intercompartmental clearance, and recovery without sedation increased the central volume of distribution and systemic clearance. In conclusion, recovery from anesthesia with concurrent fentanyl administration, with or without sedation, caused clinically significant alterations in cardiopulmonary function that influenced fentanyl disposition in healthy dogs. Advisors/Committee Members: Kerr, Carolyn (advisor).

Subjects/Keywords: fentanyl; acepromazine; dexmedetomidine; recovery; sedation; isoflurane; dog; pharmacokinetics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Keating, S. (2013). The cardiopulmonary effects and pharmacokinetics of fentanyl in the dog: The influence of isoflurane anesthesia and sedative administration during anesthetic recovery. (Doctoral Dissertation). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/6548

Chicago Manual of Style (16^th Edition):

Keating, Stephanie. “The cardiopulmonary effects and pharmacokinetics of fentanyl in the dog: The influence of isoflurane anesthesia and sedative administration during anesthetic recovery.” 2013. Doctoral Dissertation, University of Guelph. Accessed January 18, 2021. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/6548.

MLA Handbook (7^th Edition):

Keating, Stephanie. “The cardiopulmonary effects and pharmacokinetics of fentanyl in the dog: The influence of isoflurane anesthesia and sedative administration during anesthetic recovery.” 2013. Web. 18 Jan 2021.

Vancouver:

Keating S. The cardiopulmonary effects and pharmacokinetics of fentanyl in the dog: The influence of isoflurane anesthesia and sedative administration during anesthetic recovery. [Internet] [Doctoral dissertation]. University of Guelph; 2013. [cited 2021 Jan 18]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/6548.

Council of Science Editors:

Keating S. The cardiopulmonary effects and pharmacokinetics of fentanyl in the dog: The influence of isoflurane anesthesia and sedative administration during anesthetic recovery. [Doctoral Dissertation]. University of Guelph; 2013. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/6548

University of Guelph

9. Sanchez, Andrea. Evaluation of Diphenhydramine as an Antihistamine in Dogs Anesthetized for Surgical Excision of Mast Cell Tumours.

Degree: Doctor of Veterinary Science, Department of Clinical Studies, 2015, University of Guelph

URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9133

► This thesis determined in phase 1 the pharmacokinetics and cardio-respiratory effects of diphenhydramine (DHP) in conscious research dogs administered 1 mg/kg, IV, or 2 mg/kg,… (more)

▼ This thesis determined in phase 1 the pharmacokinetics and cardio-respiratory effects of diphenhydramine (DHP) in conscious research dogs administered 1 mg/kg, IV, or 2 mg/kg, IM. Phase 2 consisted of a blinded clinical trial to investigate the effectiveness of DPH in anesthetized dogs to prevent the negative cardiovascular effects associated with potential histamine release during surgical excision of mast cell tumours (MCT). Dogs were anesthetized with a balanced anesthetic and analgesic technique and then allocated to receive DPH (1 mg/kg, IV) or saline. Plasma DPH and histamine concentrations were measured and correlated with cardio-respiratory parameters. Phase 1 results provided descriptive pharmacokinetics of DPH administered IV or IM in healthy dogs. Cardio-respiratory parameters remained within normal limits during the experiment and no behavioural changes were associated with DPH administration. The IV protocol was chosen for the clinical phase 2 under anesthesia, due to a shorter time to maximal concentrations (Tmax) of 6.0 ± 0.3 min versus 45 ± 5.1 min for the IM group. During the clinical phase 2, plasma concentrations of DPH remained above concentrations considered therapeutic (25 ng/mL) in humans until the end of surgery. Despite the lack of statistical differences in histamine concentrations throughout anesthesia between groups, higher histamine concentrations were measured during maximal manipulation of the tumour. Mean arterial and diastolic blood pressures were significantly lower in DPH than in the saline group during surgical excision of the tumour. These results contradict the assumption that hypotension is more likely in dogs undergoing MCT excision that have not received DPH. Values for cardio-respiratory parameters in both groups were considered within acceptable limits for anesthetized dogs. In dogs, DPH can be administered by either IV or IM routes at 1 mg/kg and 2 mg/kg, respectively, to yield plasma concentrations that exceed therapeutic concentrations in humans without noticeable adverse behavioural or cardio-respiratory side effects. The administration of DPH prior to surgical removal of MCT in dogs did not have clear clinical anesthetic differences related to cardio-respiratory responses compared to dogs receiving a saline placebo. Advisors/Committee Members: Valverde, Alexander (advisor).

Subjects/Keywords: Pharmacokinetics; Anesthesia; Antihistamines; Mast cell tumour; Histamine; Diphenhydramine; Isoflurane; Cardiovascular

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sanchez, A. (2015). Evaluation of Diphenhydramine as an Antihistamine in Dogs Anesthetized for Surgical Excision of Mast Cell Tumours. (Doctoral Dissertation). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9133

Chicago Manual of Style (16^th Edition):

Sanchez, Andrea. “Evaluation of Diphenhydramine as an Antihistamine in Dogs Anesthetized for Surgical Excision of Mast Cell Tumours.” 2015. Doctoral Dissertation, University of Guelph. Accessed January 18, 2021. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9133.

MLA Handbook (7^th Edition):

Sanchez, Andrea. “Evaluation of Diphenhydramine as an Antihistamine in Dogs Anesthetized for Surgical Excision of Mast Cell Tumours.” 2015. Web. 18 Jan 2021.

Vancouver:

Sanchez A. Evaluation of Diphenhydramine as an Antihistamine in Dogs Anesthetized for Surgical Excision of Mast Cell Tumours. [Internet] [Doctoral dissertation]. University of Guelph; 2015. [cited 2021 Jan 18]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9133.

Council of Science Editors:

Sanchez A. Evaluation of Diphenhydramine as an Antihistamine in Dogs Anesthetized for Surgical Excision of Mast Cell Tumours. [Doctoral Dissertation]. University of Guelph; 2015. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9133

10. 장, 동진. Isoflurane-induced post-conditioning in senescent hearts is attenuated by failure to activate reperfusion injury salvage kinase pathway.

Degree: 2013, Ajou University

URL: http://repository.ajou.ac.kr/handle/201003/8626 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000013446

►

BACKGROUND: We investigated the cardioprotective effects of isoflurane administered at the onset of reperfusion in senescent rat in vivo, and the activation of the reperfusion… (more)

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BACKGROUND: We investigated the cardioprotective effects of isoflurane administered at the onset of reperfusion in senescent rat in vivo, and the activation of the reperfusion injury salvage kinase (RISK) pathway to address a possible mechanism underlying age-related differences. METHODS AND RESULTS: Male Wistar rats were assigned to age groups (young, 3–5 months; old, 20–24 months), and randomly selected to receive isoflurane (1 minimum alveolar concentration) or not for 3 min before and 2 min after reperfusion (ISO postC). Rats were subjected to coronary occlusion for 30 min followed by 2 h of reperfusion. Western blot analysis was used to assess the phosphorylation of extracellular signal-regulated kinase (ERK1/2), Akt, and GSK3β 15 min after reperfusion. Brief administration of isoflurane 3min before and 2 min after the initiation of early reperfusion reducedinfarct size (56 ± 8% of left ventricular area at risk, mean ± standard deviation) compared with controls (68 ± 4%) in young rats, but had no effect in old rats (56 ± 8% in ISO postC and 56 ± 10% in control, respectively). Phosphorylation of ERK1/2, Akt, and GSK3β were increased in the young ISO postC group but not in the old ISO postC group compared with control groups of the respective ages. CONCLUSIONS: We demonstrated that isoflurane postconditions the heart in young but not in senescent rats. Failure to activate RISK pathway may contribute to attenuation of isofluraneinduced post-conditioning effect in senescent rats.

본 연구에서는 고령 쥐에서 isoflurane 을 심근의 재관류 시기에 투여하였을 때 흡입마취제의 심근보호 효과를 젊은 쥐와 비교하여 알아보고자 하였다. 또한 이러한 차이를 나타내는 이유로 reperfusion injury salvage kinase (RISK) pathway 의 활성화 정도를 측정하여 비교해 보고자 하였다. 수컷 Wistar 쥐를 나이에 따라 3-5 개월 된 젊은 쥐와 20-24 개월 된 고령 쥐로 나누고 각각을 다시 재관류 시작 3 분 전부터 2 분 후까지 5 분간 isoflurane (1최소 폐포 농도)을 투여 받는 그룹(ISO popstC 군)과 그렇지 않은 그룹(대조군)으로 무작위로 나누어 실험을 진행하였다. 모든 그룹에서 관상동맥의 결찰은 30 분간 유지하였고 이후 2 시간 동안 재관류를 하였다. 재관류 시작 후 15 분이 경과하였을 때 얻은 심근 조직으로 western blot analysis 를 시행하여 ERK1/2, Akt, GSK3β 의 인산화 정도를 측정하였다. 젊은 쥐에서는 isoflurane 을 투여한 군에서 심근 경색의 정도가 대조군에 비하여 감소하여 나타났으나 (ISO postC 군; 56±8% of left ventricle area at risk, 대조군; 68±4%, 평균±표준편차) 고령 쥐에서는 유의한 차이를 보이지 않았다 (ISO postC 군; 56±8%, 대조군; 56±10%). Isoflurane 의 투여 시 젋은 쥐에서는 ERK1/2, Akt, GSK3β 의 인산화 정도가 증가하였으나 고령 쥐에서는 차이가 없었다. Isoflurane 의 후조건화 효과가 젊은 쥐에서는 유의하게 나타났으나 고령 쥐에서는 나타나지 않았고 이것은 고령 쥐에서 RISK pathway 가 활성화 되지 못한 것과 연관이 있을 것으로 보인다.

ABSTRACT i TABLE OF CONTENTS ii LIST OF FIGURES iii LIST OF TABLES iv Ⅰ. INTRODUCTION 1 Ⅱ. MATERIALS AND METHODS 3 Ⅲ. RESULTS 7 Ⅳ. DISCUSSION 13 Ⅴ. CONCLUSION 16 REFERENCES 17 국문요약 21 Fig.1. Schematic diagram depicting the experimental protocol 4 Fig.2. Myocardial infarct size 9 Fig.3. Western blot analysis 10 Table 1. Hemodynamic data 7 Table 2. Weights and area at risk 8

Doctor

Advisors/Committee Members: 대학원 의학과, 200924408, 장, 동진.

Subjects/Keywords: Heart; isoflurane; post-conditioning; RISK pathway; 심근; 후조건화

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

장, �. (2013). Isoflurane-induced post-conditioning in senescent hearts is attenuated by failure to activate reperfusion injury salvage kinase pathway. (Thesis). Ajou University. Retrieved from http://repository.ajou.ac.kr/handle/201003/8626 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000013446

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

장, 동진. “Isoflurane-induced post-conditioning in senescent hearts is attenuated by failure to activate reperfusion injury salvage kinase pathway.” 2013. Thesis, Ajou University. Accessed January 18, 2021. http://repository.ajou.ac.kr/handle/201003/8626 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000013446.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

장, 동진. “Isoflurane-induced post-conditioning in senescent hearts is attenuated by failure to activate reperfusion injury salvage kinase pathway.” 2013. Web. 18 Jan 2021.

Vancouver:

장 �. Isoflurane-induced post-conditioning in senescent hearts is attenuated by failure to activate reperfusion injury salvage kinase pathway. [Internet] [Thesis]. Ajou University; 2013. [cited 2021 Jan 18]. Available from: http://repository.ajou.ac.kr/handle/201003/8626 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000013446.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

장 �. Isoflurane-induced post-conditioning in senescent hearts is attenuated by failure to activate reperfusion injury salvage kinase pathway. [Thesis]. Ajou University; 2013. Available from: http://repository.ajou.ac.kr/handle/201003/8626 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000013446

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

11. 김, 은정. Effect of Isoflurane Post-treatment on tPA-exaggerated Brain Injury in a Rat Ischemic Stroke Model.

Degree: 2015, Ajou University

URL: http://repository.ajou.ac.kr/handle/201003/11884 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000020434

►

Intravenous tissue-type plasminogen activator (tPA) is recognized as the standard treatment for ischemic stroke. However, its narrow therapeutic window and association with an increased risk… (more)

▼

Intravenous tissue-type plasminogen activator (tPA) is recognized as the standard treatment for ischemic stroke. However, its narrow therapeutic window and association with an increased risk of intracranial hemorrhage have required caution when used. In this context, several approaches are required to deal with the shortcomings of such a double-edged drug. Anesthetics are known to protect against ischemic reperfusion injury, and their protective role in ischemic post-conditioning is crucial for reducing ischemia-related injury. The aim of this study was to assess the effect of isoflurane post-treatment on intracranial hemorrhage and cerebral infarction after tPA treatment for transient cerebral ischemia. Cerebral ischemia was modeled in male Sprague-Dawley rats (n = 32) by occluding the right middle cerebral artery for 1 hour (h), followed by intravenous tPA administration. Rats were randomly divided into control and isoflurane post-treatment group, and isoflurane post-treatment group was post-treated by administering 1.5% isoflurane for 1 h from the start of reperfusion. 24 h after reperfusion, neurobehavioral changes were assessed. The extent of cerebral infarction and intracranial hemorrhage were also assessed by quantification of infarction volume and cerebral hemoglobin concentration from brain tissue, respectively. Neurobehavioral testing showed better functional outcomes in the isoflurane post-treatment group than the control group. The extent of cerebral infarction and intracranial hemorrhage were both reduced in isoflurane post-treatment group compared to control group. Isoflurane post-treatment may mitigate infarction volume and intracranial hemorrhage in tPA-exaggerated brain injury. Our findings provide an encouraging novel approach for enhancing clinical outcomes in tPA-exaggerated brain injury.

I. INTRODUCTION II. MATERIALS AND METHODS A. MATERIALS 1. Animals B. METHODS 1. Animal Preparation 2. Middle Cerebral Artery Occlusion Model and Grouping 3. Neurobehavioral Assessment 4. Measurement of Infarct Volume and Hemorrhagic Transformation 5. Statistical Analysis III. RESULTS IV. DISCUSSION V. CONCLUSION REFERENCES 국문요약

Doctor

Advisors/Committee Members: 대학원 의학과, 201325054, 김, 은정.

Subjects/Keywords: Tissue Plasminogen Activator; Intracranial Hemorrhages; Isoflurane; Ischemic Postconditioning; 조직플라스미노겐활성제; 두개내출혈; 허혈성후처치

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

김, �. (2015). Effect of Isoflurane Post-treatment on tPA-exaggerated Brain Injury in a Rat Ischemic Stroke Model. (Thesis). Ajou University. Retrieved from http://repository.ajou.ac.kr/handle/201003/11884 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000020434

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

김, 은정. “Effect of Isoflurane Post-treatment on tPA-exaggerated Brain Injury in a Rat Ischemic Stroke Model.” 2015. Thesis, Ajou University. Accessed January 18, 2021. http://repository.ajou.ac.kr/handle/201003/11884 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000020434.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

김, 은정. “Effect of Isoflurane Post-treatment on tPA-exaggerated Brain Injury in a Rat Ischemic Stroke Model.” 2015. Web. 18 Jan 2021.

Vancouver:

김 �. Effect of Isoflurane Post-treatment on tPA-exaggerated Brain Injury in a Rat Ischemic Stroke Model. [Internet] [Thesis]. Ajou University; 2015. [cited 2021 Jan 18]. Available from: http://repository.ajou.ac.kr/handle/201003/11884 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000020434.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

김 �. Effect of Isoflurane Post-treatment on tPA-exaggerated Brain Injury in a Rat Ischemic Stroke Model. [Thesis]. Ajou University; 2015. Available from: http://repository.ajou.ac.kr/handle/201003/11884 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000020434

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

12. Dunningham, Helen. Modelling lung and tissue gas transfer using a membrane oxygenator circuit : determining the effects of a volatile anaesthetic agent and a haemoglobin substitute on oxygen, carbon dioxide and nitric oxide diffusion.

Degree: PhD, 2011, Anglia Ruskin University

URL: http://arro.anglia.ac.uk/id/eprint/211595/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.561315

► A novel in vitro membrane oxygenator circuit was developed to test gas exchange where particular elements could be examined whilst keeping other variables constant. The… (more)

Subjects/Keywords: 612.22; membrane oxygenator; deoxygenator; isoflurane; nitric oxide; HBOC; oxyglobin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dunningham, H. (2011). Modelling lung and tissue gas transfer using a membrane oxygenator circuit : determining the effects of a volatile anaesthetic agent and a haemoglobin substitute on oxygen, carbon dioxide and nitric oxide diffusion. (Doctoral Dissertation). Anglia Ruskin University. Retrieved from http://arro.anglia.ac.uk/id/eprint/211595/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.561315

Chicago Manual of Style (16^th Edition):

Dunningham, Helen. “Modelling lung and tissue gas transfer using a membrane oxygenator circuit : determining the effects of a volatile anaesthetic agent and a haemoglobin substitute on oxygen, carbon dioxide and nitric oxide diffusion.” 2011. Doctoral Dissertation, Anglia Ruskin University. Accessed January 18, 2021. http://arro.anglia.ac.uk/id/eprint/211595/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.561315.

MLA Handbook (7^th Edition):

Dunningham, Helen. “Modelling lung and tissue gas transfer using a membrane oxygenator circuit : determining the effects of a volatile anaesthetic agent and a haemoglobin substitute on oxygen, carbon dioxide and nitric oxide diffusion.” 2011. Web. 18 Jan 2021.

Vancouver:

Dunningham H. Modelling lung and tissue gas transfer using a membrane oxygenator circuit : determining the effects of a volatile anaesthetic agent and a haemoglobin substitute on oxygen, carbon dioxide and nitric oxide diffusion. [Internet] [Doctoral dissertation]. Anglia Ruskin University; 2011. [cited 2021 Jan 18]. Available from: http://arro.anglia.ac.uk/id/eprint/211595/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.561315.

Council of Science Editors:

Dunningham H. Modelling lung and tissue gas transfer using a membrane oxygenator circuit : determining the effects of a volatile anaesthetic agent and a haemoglobin substitute on oxygen, carbon dioxide and nitric oxide diffusion. [Doctoral Dissertation]. Anglia Ruskin University; 2011. Available from: http://arro.anglia.ac.uk/id/eprint/211595/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.561315

University of Oxford

13. Northing, Richard J. An electrochemical sensor for forane.

Degree: PhD, 1989, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:4b9a19f1-919c-4fc1-a39b-8bb3ac706f9f ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238264

► This thesis is concerned with the development and laboratory assessment of an electrochemical sensor for the detection and measurement of the volatile inhalation anaesthetic, forane.… (more)

▼ This thesis is concerned with the development and laboratory assessment of an electrochemical sensor for the detection and measurement of the volatile inhalation anaesthetic, forane. Investigations were therefore based on the heterogeneous and homogeneous reduction of this agent in non-aqueous electrolyte. Preliminary experiments at a mercury and other rotating disc electrodes (RDEs) revealed that the direct reduction of forane was not possible and therefore the use of an electron transfer mediator was examined. To this end, the radical anion of the polyaromatic compound, fluoranthene, (F), was investigated as a possible electro-reduction catalyst and the mediated reduction of the anaesthetic, via a catalytic process, demonstrated. Theory was presented for the calculation of chronoamperometric and steady state responses at the RDE resulting from one electron transfer and coupled (catalytic) homogeneous kinetic processes. The latter enabled a precise mechanism to be assigned to the F + forane process, while a comparison of the former theory with experimental chronoamperometric results was used, in conjunction with AC impedance studies, to investigate the adsorption of F at the mercury/acetonitrile interface. A polymer modified electrode, based on the polymer poly-(11-vinylfluoranthene) was demonstrated to be effective in the heterogeneous reduction of forane but displayed only a limited lifetime. Therefore, a Clark-type membrane electrode was constructed and the detection and measurement of forane, in the absence of oxygen, demonstrated using this device. However, the sluggish response of this sensor, together with interference problems from oxygen encouraged the development of a device which utilised a channel electrode (ChE) sensing approach. Theory was presented for the deduction of steady state currents at the ChE resulting from coupled catalytic kinetics and this was used to demonstrate that the same mechanism for the F + forane system operated at the ChE as the RDE. The conventional ChE was then modified by the incorporation of a membrane and this sensor, which was shown to operate successfully in the presence of high concentrations of oxygen and nitrous oxide, responded linearly to forane, while displaying an excellent response time of under ten seconds. The device should find application in clinical monitoring.

Subjects/Keywords: 615.1; Electrochemical sensors : Isoflurane

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Northing, R. J. (1989). An electrochemical sensor for forane. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:4b9a19f1-919c-4fc1-a39b-8bb3ac706f9f ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238264

Chicago Manual of Style (16^th Edition):

Northing, Richard J. “An electrochemical sensor for forane.” 1989. Doctoral Dissertation, University of Oxford. Accessed January 18, 2021. http://ora.ox.ac.uk/objects/uuid:4b9a19f1-919c-4fc1-a39b-8bb3ac706f9f ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238264.

MLA Handbook (7^th Edition):

Northing, Richard J. “An electrochemical sensor for forane.” 1989. Web. 18 Jan 2021.

Vancouver:

Northing RJ. An electrochemical sensor for forane. [Internet] [Doctoral dissertation]. University of Oxford; 1989. [cited 2021 Jan 18]. Available from: http://ora.ox.ac.uk/objects/uuid:4b9a19f1-919c-4fc1-a39b-8bb3ac706f9f ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238264.

Council of Science Editors:

Northing RJ. An electrochemical sensor for forane. [Doctoral Dissertation]. University of Oxford; 1989. Available from: http://ora.ox.ac.uk/objects/uuid:4b9a19f1-919c-4fc1-a39b-8bb3ac706f9f ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238264

University of Oxford

14. Goddard, Helen. Electrophysiological effects of fentanyl, halothane and isoflurane on guinea-pig isolated ventricular myocytes.

Degree: PhD, 2002, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:58f6f4e2-aaa9-4913-a7c2-5568e2f8d72f ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270018

► Ischaemic periods which lust only several minutes can result in a reversible reduction in cardiac contractility known as cardiac stunning. This is a potentially dangerous… (more)

Subjects/Keywords: 615; Fentanyl; Halothane; Isoflurane

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Goddard, H. (2002). Electrophysiological effects of fentanyl, halothane and isoflurane on guinea-pig isolated ventricular myocytes. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:58f6f4e2-aaa9-4913-a7c2-5568e2f8d72f ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270018

Chicago Manual of Style (16^th Edition):

Goddard, Helen. “Electrophysiological effects of fentanyl, halothane and isoflurane on guinea-pig isolated ventricular myocytes.” 2002. Doctoral Dissertation, University of Oxford. Accessed January 18, 2021. http://ora.ox.ac.uk/objects/uuid:58f6f4e2-aaa9-4913-a7c2-5568e2f8d72f ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270018.

MLA Handbook (7^th Edition):

Goddard, Helen. “Electrophysiological effects of fentanyl, halothane and isoflurane on guinea-pig isolated ventricular myocytes.” 2002. Web. 18 Jan 2021.

Vancouver:

Goddard H. Electrophysiological effects of fentanyl, halothane and isoflurane on guinea-pig isolated ventricular myocytes. [Internet] [Doctoral dissertation]. University of Oxford; 2002. [cited 2021 Jan 18]. Available from: http://ora.ox.ac.uk/objects/uuid:58f6f4e2-aaa9-4913-a7c2-5568e2f8d72f ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270018.

Council of Science Editors:

Goddard H. Electrophysiological effects of fentanyl, halothane and isoflurane on guinea-pig isolated ventricular myocytes. [Doctoral Dissertation]. University of Oxford; 2002. Available from: http://ora.ox.ac.uk/objects/uuid:58f6f4e2-aaa9-4913-a7c2-5568e2f8d72f ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270018

University of Gothenburg / Göteborgs Universitet

15. Redfors, Björn. Pathophysiology and treatment in experimental stress-induced cardiomyopathy.

Degree: 2014, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/36737

► Background: Stress-induced cardiomyopathy (SIC) is an acute cardiac affliction associated with significant morbidity and mortality. It is characterized by potentially reversible regional myocardial akinesia which… (more)

▼ Background: Stress-induced cardiomyopathy (SIC) is an acute cardiac affliction associated with significant morbidity and mortality. It is characterized by potentially reversible regional myocardial akinesia which may involve up to 70% of the heart. An episode of SIC is often preceded by a strong emotional or somatic stressor. Catecholamine is implicated in the pathogenesis of SIC but the mechanisms involved are unknown. Neither American nor European guidelines provide any treatment recommendations for SIC, and no randomized clinical studies on treatment in SIC have been performed. Aims: The aim of my thesis was to develop a representative animal model of SIC that can be used to study the pathophysiology behind the syndrome and to test potential treatment strategies. Methods: We used 10-week-old male Sprague Dawley rats. The SIC models presented in the thesis are based on intraperitoneal administration of a catecholamine, given as a bolus. We infused fluid and/or pharmacological agents through the right jugular vein and measured arterial blood pressure through a catheter inserted in the right common carotid artery. We used small animal echocardiography to study cardiac morphology and function and performed histological analyses of cardiac tissue to detect perturbations in lipid metabolism. Results: In manuscript I we reproduced the clinical phenomena associated with SIC in rats by administration of catecholamine. In manuscript II we show that perfusion defects did not appear to precede the development of SIC in our rat model. In manuscript III we show that the development and morphological type of SIC appear to depend on hemodynamic factors rather than specific adrenoreceptor subtypes. In manuscript IV we show that left ventricular filling pressure and cardiac output appear to be near-normal in experimental and clinical SIC despite hypotension. We also show that interventions for pharmacologically increased blood pressure increase acute mortality in the rat model. In manuscript V we show, in two different experimental set-ups, that isoflurane anesthesia dose-dependently prevents experimental SIC. Conclusion: Clinical SIC phenomena can be reliably reproduced in rat models. Because development of SIC appears to depend on hemodynamic factors, SIC should be considered a cardiocirculatory syndrome, in which the cardiomyopathy is one component. Isoflurane could be the anesthetic of choice in patients at increased risk of developing SIC, e.g. patients with severe somatic illness.

Subjects/Keywords: adrenoceptor; cardiocirculatory syndrome; catecholamine; echocardiography; isoflurane; stress-induced cardiomyopathy; Takotsubo cardiomyopathy

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APA (6^th Edition):

Redfors, B. (2014). Pathophysiology and treatment in experimental stress-induced cardiomyopathy. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/36737

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Redfors, Björn. “Pathophysiology and treatment in experimental stress-induced cardiomyopathy.” 2014. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed January 18, 2021. http://hdl.handle.net/2077/36737.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Redfors, Björn. “Pathophysiology and treatment in experimental stress-induced cardiomyopathy.” 2014. Web. 18 Jan 2021.

Vancouver:

Redfors B. Pathophysiology and treatment in experimental stress-induced cardiomyopathy. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2014. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2077/36737.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Redfors B. Pathophysiology and treatment in experimental stress-induced cardiomyopathy. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2014. Available from: http://hdl.handle.net/2077/36737

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of South Florida

16. Pillai, Aditi. Effects of Body Temperature and General Anesthetics on Intraocular Pressure in Rats.

Degree: 2018, University of South Florida

URL: https://scholarcommons.usf.edu/etd/7351

► Ocular hypertension has been identified as the fundamental risk factor in glaucoma which is the leading cause for irreversible blindness in the world. Understanding the… (more)

▼ Ocular hypertension has been identified as the fundamental risk factor in glaucoma which is the leading cause for irreversible blindness in the world. Understanding the different factors that affect IOP is of utmost importance in clinical management as IOP is considered as the fundamental factor in assessing the efficiency of glaucoma medications. Several studies have attempted to assess factors that could affect IOP including age, body position, blood pressure, anesthetics commonly used during eye operations, etc. However, in most of these studies IOP is measured under anesthesia using rodent models and these anesthetics could affect the IOP measurements directly or indirectly. The use of tonometry in such experiments also includes certain limitations like acquiring IOP at discrete moments in time, human error while handling the instrument and stress induced spikes in IOP while handling awake animals. This study uses a wireless continuously monitoring device to eliminate these limitations while also acquiring IOP at a higher rate. Anesthesia induction is known to lower body temperature. However, previous studies on the effects of various anesthetic agents fail to take into account this drop in body temperature which could potentially lead to erroneous results. This thesis focuses on studying the effects of two commonly used anesthetic agents, isoflurane and ketamine while accounting for loss in body temperature. The effects of changing body temperature on intraocular pressure was also studied to help understand the effects of these factors accurately. There was a statistically significant drop (p<0.001) in intraocular pressure post isoflurane induction with no heat support across several animals. The addition of heat support in the next set of experiments resulted in an almost steady pressure throughout the experiment. Since the body temperature was maintained constant throughout the experiment, there was no statistically significant difference (p>0.05) among IOP’s for the awake and anesthetized condition. This conclusion was then confirmed by obtaining a direct effect of changing body temperature on IOP. There was a rise in IOP while the animal was placed on a 42 degree Celsius heating pad and a drop in IOP while the animal was placed on a 20 degree Celsius surface with no heat support. The corresponding changes in body temperature were confirmed using a rectal thermometer. There were no significant changes in the IOP measured by the sensor while measuring pressure with the iCare tonolab. Applanation tonometry however produced an average mean intraocular pressure increase of 2.11 ± 1.62 mmHg.

Subjects/Keywords: animal model; isoflurane; ketamine; tonometry; Biomedical Engineering and Bioengineering

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pillai, A. (2018). Effects of Body Temperature and General Anesthetics on Intraocular Pressure in Rats. (Thesis). University of South Florida. Retrieved from https://scholarcommons.usf.edu/etd/7351

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pillai, Aditi. “Effects of Body Temperature and General Anesthetics on Intraocular Pressure in Rats.” 2018. Thesis, University of South Florida. Accessed January 18, 2021. https://scholarcommons.usf.edu/etd/7351.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pillai, Aditi. “Effects of Body Temperature and General Anesthetics on Intraocular Pressure in Rats.” 2018. Web. 18 Jan 2021.

Vancouver:

Pillai A. Effects of Body Temperature and General Anesthetics on Intraocular Pressure in Rats. [Internet] [Thesis]. University of South Florida; 2018. [cited 2021 Jan 18]. Available from: https://scholarcommons.usf.edu/etd/7351.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pillai A. Effects of Body Temperature and General Anesthetics on Intraocular Pressure in Rats. [Thesis]. University of South Florida; 2018. Available from: https://scholarcommons.usf.edu/etd/7351

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

17. Mantziaras, Georgios. Συγκριτική δράση του ισοφλουρανίου και του σεβοφλουρανίου σε σήψη: πειραματική μελέτη σε κονίκλους.

Degree: 2012, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

URL: http://hdl.handle.net/10442/hedi/34701

► Septic patients often need to be surgically operated, in order to eliminate the source of sepsis. The choice of the proper anaesthetic protocol is difficult,… (more)

▼ Septic patients often need to be surgically operated, in order to eliminate the source of sepsis. The choice of the proper anaesthetic protocol is difficult, as the majority of anaesthetic drugs suppress even more the already depressed cardio-respiratory function.Isoflurane and sevoflurane are the most commonly used volatile anaesthetic agents in veterinary and human medicine. The aim of the present study was to compare isoflurane with sevoflurane when used for the maintenance of anaesthesia in healthy and septic rabbits as well as to evaluate the influence of sepsis in rabbit’s anaesthesia. The experimental protocol was approved by the Committee of Evaluation and Approval of Experimental Surgery Protocols of the Foundation for Biomedical Research of the Academy of Athens, and the Veterinary Directorate of the Prefecture of Athens according to the Greek legislation in accordance with the Council Directive of the European Union.A preliminary study was conducted in sixteen male rabbits, in order to standardize all the anaesthetic, surgical and echocardiographic procedures of the experiment.For the main study, thirty six (36) male, intact, New Zealand White rabbits of a mean body weight 3.3 kg were used. They were divided in the following groups:a. Group control isoflurane (CI): Isoflurane was administered for 120 minutes, in 9 clinical healthy rabbits after premedication and anaesthesia induction.b. Group control sevoflurane (CS): Sevoflurane was administered for 120 minutes, in 9 clinical healthy rabbits after premedication and anaesthesia induction.c. Group sepsis isoflurane (SI): Isoflurane was administered for 120 minutes, in 9 septic rabbits after premedication and anaesthesia induction. d. Group sepsis sevoflurane (SS): Sevoflurane was administered for 120 minutes, in 9 septic rabbits after premedication and anaesthesia induction.Sepsis was induced with the intravenous administration of a clinical strain of Escherichia coli. Induction of sepsis was confirmed by the presence of leucopenia and hypo- or hyperthermia, according to the established SIRS criteria.All the animals were premedicated with intramuscular administration of midazolam and butorphanol and anaesthesia was induced with the administration of ketamine. All the rabbits were mechanically ventilated after tracheal intubation.For each rabbit the time needed for anaesthesia induction was measured. Arterial pressure was monitored in the carotid artery, which was previously surgically catheterized. Minimum anaesthetic concentration (vaporizer setting) of isoflurane or sevoflurane for maintenance of anaesthesia was estimated individually. Anaesthesia was maintained for a total period of 2 hours. Right after the end of the administration of the volatile anaesthetic agent, recovery was monitored for a period of 1 hour, and the time needed for the recovery of several reflexes was estimated.During anaesthesia heart rate and arterial blood pressure were monitored, while the size and contractility of the heart was estimated with echocardiography.The results of the…

Subjects/Keywords: Σεβοφλουράνιο; Ισοφλουράνιο; Σήψη; Κόνικλοι; Υπερηχοκαρδιογράφημα; Sevoflurane; Isoflurane; Sepsis; Rabbits; Echocardiography

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mantziaras, G. (2012). Συγκριτική δράση του ισοφλουρανίου και του σεβοφλουρανίου σε σήψη: πειραματική μελέτη σε κονίκλους. (Thesis). Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Retrieved from http://hdl.handle.net/10442/hedi/34701

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mantziaras, Georgios. “Συγκριτική δράση του ισοφλουρανίου και του σεβοφλουρανίου σε σήψη: πειραματική μελέτη σε κονίκλους.” 2012. Thesis, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Accessed January 18, 2021. http://hdl.handle.net/10442/hedi/34701.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mantziaras, Georgios. “Συγκριτική δράση του ισοφλουρανίου και του σεβοφλουρανίου σε σήψη: πειραματική μελέτη σε κονίκλους.” 2012. Web. 18 Jan 2021.

Vancouver:

Mantziaras G. Συγκριτική δράση του ισοφλουρανίου και του σεβοφλουρανίου σε σήψη: πειραματική μελέτη σε κονίκλους. [Internet] [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2012. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10442/hedi/34701.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mantziaras G. Συγκριτική δράση του ισοφλουρανίου και του σεβοφλουρανίου σε σήψη: πειραματική μελέτη σε κονίκλους. [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2012. Available from: http://hdl.handle.net/10442/hedi/34701

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

The Ohio State University

18. Sams, Lisa Michelle. The Effect of Morphine-Lidocaine-Ketamine-Dexmedetomidine Co-infusion on Minimum Alveolar Concentration of Isoflurane in Dogs.

Degree: MS, Veterinary Clinical Sciences, 2011, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1306860828

► The purpose of this study was to determine the effects of an infusion of dexmedetomidine, a co-infusion of morphine-lidocaine-ketamine (MLK), and a co-infusion of… (more)

▼ The purpose of this study was to determine the effects of an infusion of dexmedetomidine, a co-infusion of morphine-lidocaine-ketamine (MLK), and a co-infusion of dexmedetomidine-morphine-lidocaine-ketamine (alpha-MLK) on minimum alveolar concentration (MAC) of isoflurane in dogs. The MAC of an inhalant anesthetic required to prohibit purposeful movement is a measure of anesthetic potency (Eger et al 1965). Isoflurane is the most commonly used inhalant anesthetic in veterinary practice (Lozano et al 2009), but has potent vasodilatory effects and causes a dose-dependent decrease in mean arterial pressure in anesthetized dogs (Steffey and Howland 1977). Additional drugs are used during anesthesia to decrease the inhalant anesthetic requirement, a concept referred to as balanced anesthesia. Each of the drugs we infused has a different central nervous system receptor mechanism of action. Co-infusion of MLK, as well as the infusion of each drug separately, has been shown to reduce MAC in isoflurane-anesthetized dogs (Muir et al 2003). Dexmedetomidine, an alpha-2 agonist, has been shown to reduce isoflurane MAC in dogs (Pascoe et al 2006). Dexmedetomidine is a commonly used sedative with analgesic and muscle relaxant properties. The effect of a co-infusion of alpha-MLK on isoflurane anesthesia has not been critically evaluated in the dog. Our hypothesis was that infusion of alpha-MLK would significantly decrease isoflurane MAC (MAC-Iso) compared to dexmedetomidine or MLK infusions. For this study, six dogs were anesthetized to determine MAC-Iso (baseline). Following MAC-Iso determination, each dog was anesthetized on three separate occasions with isoflurane, with a minimum of 7 days between anesthetic episodes. On each occasion, and in random order, dexmedetomidine, MLK, or alpha-MLK infusions were administered, and MAC was determined. Additionally, hemodynamic and metabolic parameters as well as bispectral index (BIS) were measured during each experiment. The investigator was blinded to the infusion given. Data were analyzed using ANOVA for repeated measures. Dunnett and Tukey posttests were performed to identify differences within and among groups, respectively, when differences were detected. The MAC-Iso was 1.3 ± 0.15%. Dexmedetomidine, MLK, and alpha-MLK significantly lowered MAC-Iso by 30, 55, and 90%, respectively. Heart rate was significantly decreased from baseline in all infusion groups. Heart rate did not differ significantly between dexmedetomidine and alpha-MLK infusion groups. Mean arterial pressure for alpha-MLK increased significantly from baseline. Systemic vascular resistance was significantly increased for the dexmedetomidine and alpha-MLK infusion groups. The BIS values increased significantly compared to baseline for the MLK and alpha-MLK infusion groups. There was no significant difference for time to extubation and sternal recumbency among groups. Infusions of dexmedetomidine, MLK, and alpha-MLK reduced MAC-Iso in dogs. Changes in cardiovascular parameters were within… Advisors/Committee Members: Lerche, Phillip (Advisor).

Subjects/Keywords: Veterinary Services; MAC; isoflurane; multimodal anesthesia; dogs; dexmedetomidine; BIS

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sams, L. M. (2011). The Effect of Morphine-Lidocaine-Ketamine-Dexmedetomidine Co-infusion on Minimum Alveolar Concentration of Isoflurane in Dogs. (Masters Thesis). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1306860828

Chicago Manual of Style (16^th Edition):

Sams, Lisa Michelle. “The Effect of Morphine-Lidocaine-Ketamine-Dexmedetomidine Co-infusion on Minimum Alveolar Concentration of Isoflurane in Dogs.” 2011. Masters Thesis, The Ohio State University. Accessed January 18, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1306860828.

MLA Handbook (7^th Edition):

Sams, Lisa Michelle. “The Effect of Morphine-Lidocaine-Ketamine-Dexmedetomidine Co-infusion on Minimum Alveolar Concentration of Isoflurane in Dogs.” 2011. Web. 18 Jan 2021.

Vancouver:

Sams LM. The Effect of Morphine-Lidocaine-Ketamine-Dexmedetomidine Co-infusion on Minimum Alveolar Concentration of Isoflurane in Dogs. [Internet] [Masters thesis]. The Ohio State University; 2011. [cited 2021 Jan 18]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1306860828.

Council of Science Editors:

Sams LM. The Effect of Morphine-Lidocaine-Ketamine-Dexmedetomidine Co-infusion on Minimum Alveolar Concentration of Isoflurane in Dogs. [Masters Thesis]. The Ohio State University; 2011. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1306860828

The Ohio State University

19. Aarnes, Turi K. Fluid administration for the treatment of isoflurane-induced hypotension in dogs.

Degree: MS, Veterinary Clinical Sciences, 2009, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1236023502

► Isoflurane is the most commonly used inhalant anesthetic in veterinary practice. Hypotension, a side effect of isoflurane anesthesia, increases morbidity and mortality. Intravenous (IV)… (more)

▼ Isoflurane is the most commonly used inhalant anesthetic in veterinary practice. Hypotension, a side effect of isoflurane anesthesia, increases morbidity and mortality. Intravenous (IV) fluid therapy is frequently proposed for correction of anesthetic-induced hypotension. The efficacy of fluid therapies for the treatment of isoflurane-induced hypotension has not been investigated. The objective of our study was to determine the effect of the IV administration of a crystalloid (Lactated Ringer’s Solution, (LRS)) or colloid (Hetastarch, HES) on isoflurane-induced hypotension in dogs. We hypothesized that IV fluid administration would correct isoflurane-induced hypotension and that HES administration would correct isoflurane-induced hypotension more rapidly, more effectively, and with a smaller volume than with LRS. Six Beagles were studied. Isoflurane minimum alveolar concentration (MAC) was individually determined. All dogs underwent each treatment in a random-ordered three-way cross-over design, separated by a minimum of 7 days: an infusion of HES, an infusion of LRS, and no IV fluid administration (NFA). Following propofol induction and isoflurane maintenance, dogs were instrumented. Dogs were maintained at 1.3 times MAC for an additional 30 minutes. Baseline data were collected. The isoflurane concentration was increased to achieve a systolic arterial blood pressure (SABP) of 80 mmHg (time 0). The isoflurane concentration required to attain a SABP of 80 mmHg was maintained for the duration of the experiment. Fluid administration in the HES and LRS groups began at time 0 at a rate of 80 mL/kg/hr. Fluid administration was discontinued if SABP returned to within 10% of baseline. If SABP did not return to within 10% of baseline values, fluid was administered to a pre-determined maximum volume: 40 mL/kg for HES and 80 mL/kg for LRS. Heart rate, SABP, mean ABP, diastolic ABP, mean pulmonary artery pressure, right atrial pressure, cardiac output, and blood volume change (BV) were measured and recorded at baseline, time 0, and at 15, 30, 45, 60, 90, and 120 minutes in all groups, and at 150 and 180 minutes in the fluid treatment groups. Blood gases, pH, lactate, electrolytes, packed cell volume (PCV), total protein (TP), albumin, colloid osmotic pressure (COP), and viscosity were determined at baseline, time 0, 15, 30, 60 and 120 minutes, and viscosity was also determined at 180 minutes in the fluid treatment groups. Blood was collected 24 hours after recovery for hemogram, PCV, TP, lactate, viscosity, and chemical profile analysis. Cardiac index (CI) and systemic vascular resistance (SVR) were calculated. Administration of 80 mL/kg of LRS did not increase SABP in any dog, while administration of 40 mL/kg or less of HES increased SABP in four of six dogs. SABP, DABP, and MABP were significantly increased in dogs that received HES compared with LRS. CI increased and SVR decreased with fluid administration. Viscosity was lower in dogs that received LRS compared with HES. PCV and TP… Advisors/Committee Members: Bednarski, Richard (Committee Chair).

Subjects/Keywords: isoflurane; anesthesia; hetastarch; hypotension

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Aarnes, T. K. (2009). Fluid administration for the treatment of isoflurane-induced hypotension in dogs. (Masters Thesis). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1236023502

Chicago Manual of Style (16^th Edition):

Aarnes, Turi K. “Fluid administration for the treatment of isoflurane-induced hypotension in dogs.” 2009. Masters Thesis, The Ohio State University. Accessed January 18, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1236023502.

MLA Handbook (7^th Edition):

Aarnes, Turi K. “Fluid administration for the treatment of isoflurane-induced hypotension in dogs.” 2009. Web. 18 Jan 2021.

Vancouver:

Aarnes TK. Fluid administration for the treatment of isoflurane-induced hypotension in dogs. [Internet] [Masters thesis]. The Ohio State University; 2009. [cited 2021 Jan 18]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1236023502.

Council of Science Editors:

Aarnes TK. Fluid administration for the treatment of isoflurane-induced hypotension in dogs. [Masters Thesis]. The Ohio State University; 2009. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1236023502

20. Keita Alassane, Ndeye Sokhna. Etude d'un modèle de neuropaludisme chez le rat et évaluation des effets pharmacologiques d'un candidat-médicament : Study of a cerebral malaria model in rats and pharmacological effects assessment of a drug-candidate.

Degree: Docteur es, Pharmacologie, 2016, Université Toulouse III – Paul Sabatier

URL: http://www.theses.fr/2016TOU30379

► Le neuropaludisme (NP) est la forme la plus mortelle du paludisme. C'est une complication neurologique observée uniquement dans les cas d'infection par Plasmodium falciparum, principalement… (more)

▼ Le neuropaludisme (NP) est la forme la plus mortelle du paludisme. C'est une complication neurologique observée uniquement dans les cas d'infection par Plasmodium falciparum, principalement chez les enfants de moins de 5 ans vivant en Afrique Sub-saharienne, et les adultes non-immuns, notamment les femmes enceintes et les touristes visitant les zones d'endémie. Les signes cliniques sont à présent bien décrits (prostration, convulsions répétées, difficultés respiratoires, coma,...), mais les mécanismes physiopathologiques conduisant au NP sont encore mal définis. Leur élucidation est rendue difficile par la localisation cérébrale de la pathologie du vivant des patients et la faible disponibilité des données nécropsiques. Bien que l'accès aux tissus humains soit limité en nombre, les résultats d'autopsie ont permis d'établir que le NP résulte d'une séquestration des globules parasités au niveau de l'endothélium intra-vasculaire, associée à une forte réaction immunitaire. La stratégie de prise en charge du NP combine un traitement étiologique à base de dérivés d'artémisinine, ou de quinine et un traitement adjuvant symptomatique destiné à pallier à la défaillance multiorganique qui est à l'origine de l'issue fatale souvent observée. Le modèle de NP expérimental actuellement le plus utilisé est le modèle souris infecté par P. berghei ANKA. La pertinence de ce modèle est toutefois remise en cause en raison notamment des différences histo-pathologiques observées par rapport à la forme humaine. En effet, les souris manifestant les symptômes du NP ne présentent que très rarement le phénomène de séquestration, caractéristique majeure du NP chez l'Homme. Par ailleurs, comparativement à la réponse immunitaire de la souris, le modèle rat s'est également révélé plus proche de la réaction de l'Homme, dans le cas d'une autre parasitose, la schistosomose. L'objectif de la première partie du projet thèse a donc été la mise en place et l'évaluation d'un modèle alternatif de NP chez le rat. Ainsi un modèle de NP chez le rat Sprague Dawley infecté par la souche murine P. berghei K173 a été caractérisé sur les plans clinique, biologique (paramètres hématologiques et biochimiques),histopathologique et du profil cytokinique (cytokines cérébrales et sériques). La forte similarité des symptômes et des lésions associées au NP du rat Sprague Dawley infecté par P. berghei K173 par rapport au NP humain permet de valider la pertinence de ce modèle pour l'étude de la physiopathologie du NP. L'objectif de la deuxième partie de mon projet de thèse a été d'évaluer les effets pharmacologiques d'un candidat-médicament, l'isoflurane, pour le traitement adjuvant du NP. Ce composé présente l'avantage d'être déjà utilisé chez l'Homme à d'autres fins thérapeutiques et dispose donc d'une autorisation de mise sur le marché. Les résultats obtenus montrent une efficacité nette de l'isoflurane avec une rémission totale des signes de paralysie pour 47.8% des rats traités ainsi qu'un gain de survie des rats NP traités de 2 à 10 jours par rapport aux rats NP non… Advisors/Committee Members: Benoît-Vical, Françoise (thesis director), Faye, Babacar (thesis director).

Subjects/Keywords: Neuropaludisme; Modèle animal; Rat Sprague Dawley; P. berghei K173; Traitement adjuvant; Isoflurane; Cerebral malaria; Animal model; Rat Sprague Dawley; P. berghei K173; Malaria adjunct treatement; Isoflurane

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Keita Alassane, N. S. (2016). Etude d'un modèle de neuropaludisme chez le rat et évaluation des effets pharmacologiques d'un candidat-médicament : Study of a cerebral malaria model in rats and pharmacological effects assessment of a drug-candidate. (Doctoral Dissertation). Université Toulouse III – Paul Sabatier. Retrieved from http://www.theses.fr/2016TOU30379

Chicago Manual of Style (16^th Edition):

Keita Alassane, Ndeye Sokhna. “Etude d'un modèle de neuropaludisme chez le rat et évaluation des effets pharmacologiques d'un candidat-médicament : Study of a cerebral malaria model in rats and pharmacological effects assessment of a drug-candidate.” 2016. Doctoral Dissertation, Université Toulouse III – Paul Sabatier. Accessed January 18, 2021. http://www.theses.fr/2016TOU30379.

MLA Handbook (7^th Edition):

Keita Alassane, Ndeye Sokhna. “Etude d'un modèle de neuropaludisme chez le rat et évaluation des effets pharmacologiques d'un candidat-médicament : Study of a cerebral malaria model in rats and pharmacological effects assessment of a drug-candidate.” 2016. Web. 18 Jan 2021.

Vancouver:

Keita Alassane NS. Etude d'un modèle de neuropaludisme chez le rat et évaluation des effets pharmacologiques d'un candidat-médicament : Study of a cerebral malaria model in rats and pharmacological effects assessment of a drug-candidate. [Internet] [Doctoral dissertation]. Université Toulouse III – Paul Sabatier; 2016. [cited 2021 Jan 18]. Available from: http://www.theses.fr/2016TOU30379.

Council of Science Editors:

Keita Alassane NS. Etude d'un modèle de neuropaludisme chez le rat et évaluation des effets pharmacologiques d'un candidat-médicament : Study of a cerebral malaria model in rats and pharmacological effects assessment of a drug-candidate. [Doctoral Dissertation]. Université Toulouse III – Paul Sabatier; 2016. Available from: http://www.theses.fr/2016TOU30379

21. Whyte, Henrietta Essie. Evaluation of the performance of photocatalytic systems for the treatment of indoor air in medical environments : Evaluation de la performance des systèmes photocatalytiques pour le traitement de l'air intérieur en milieu médical.

Degree: Docteur es, Génie des procédés et bioprocédés, 2018, Ecole nationale supérieure Mines-Télécom Atlantique Bretagne Pays de la Loire

URL: http://www.theses.fr/2018IMTA0112

►

La photocatalyse est une technologie d’oxydation avancée qui peut être utilisée pour améliorer la qualité de l'air dans les environnements intérieurs et pourrait être mise… (more)

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La photocatalyse est une technologie d’oxydation avancée qui peut être utilisée pour améliorer la qualité de l'air dans les environnements intérieurs et pourrait être mise en œuvre dans les milieux médicaux. Dans les hôpitaux, les salles d'opération sont très exigeantes en matière de qualité de l'air intérieur et nécessitent des systèmes qui minimisent les concentrations des polluants générés par les différentes activités. Dans ce travail, le devenir de deux polluants spécifiques des blocs opératoires, l’acrylonitrile (produit chimique trouvé dans la fumée chirurgicale) et l'isoflurane (gaz anesthésique) lorsqu'ils passent dans un dispositif de traitement d’air photocatalytique est étudié. Tout d'abord, une évaluation paramétrique de la dégradation de l'isoflurane et de l'acrylonitrile en étudiant l'influence de la vitesse de l'air, de l'intensité lumineuse, de la géométrie du média photocatalytique, de la concentration initiale en polluants, de la présence de co-polluants chimiques, de la présence de particules et l’humidité relative sur leur efficacité de dégradation est réalisée. En second lieu, l’innocuité de l’utilisation de ce procédé pour la dégradation de l’isoflurane et de l’acrylonitrile par l’identification des éventuels intermédiaires formés au cours de leur dégradation est étudiée. Les expériences sont menées dans un réacteur dynamique en boucle fermée conçu pour étudier les polluants à faibles concentrations. Enfin, pour mieux comprendre comment le changement de géométrie du média photocatalytique influence l'efficacité de la dégradation, des simulations avec ANSYS14.5 sont effectuées et discutées au regard des résultats expérimentaux.

Photocatalytic oxidation (PCO) is an advanced air cleaning technology that is used asa means to improve air quality in indoor environments and could potentially be used inthe operating rooms (OR). In hospitals, operating rooms (ORs) are very demanding interms of the indoor air quality (IAQ) and require systems that minimize the concentrations of pollutants. In this work, the fate of two OR pollutants acrylonitrile (chemical found insurgical smoke) and isoflurane (anesthetic gas) when they go through a PCO device was investigated. Firstly, a parametric evaluation on the degradation of isoflurane and acrylonitrile by studying the influence of air velocity, light intensity, the change in media geometry, initial pollutant concentration, presence of chemical co-pollutants, presence of particles (bioaerosols) and relative humidity on their degradation efficiencies is performed. Secondly the safety of the use of PCO for the degradation of isoflurane and acrylonitrile through the identification of possible intermediates formed during their degradation is evaluated. The experiments were conducted in a closed loop reactor which has been designed to study low concentration air pollutants and has also been recently modeled. Finally, to better understand how the change in media geometry influenced the degradation efficiency, simulations with ANSYS 14.5 were performed and discussed.

Advisors/Committee Members: Héquet, Valérie (thesis director), Subrenat, Albert (thesis director).

Subjects/Keywords: Traitement de l'air intérieur; Oxydation photocatalytique; Salle d'opération; Isoflurane; Acrylonitrile; Simulations de dynamique des fluides computationnelle; Indoor air treatment; Photocatalytic oxidation; Operating room; Isoflurane; Acrylonitrile; Computational fluid dynamics; 620

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Whyte, H. E. (2018). Evaluation of the performance of photocatalytic systems for the treatment of indoor air in medical environments : Evaluation de la performance des systèmes photocatalytiques pour le traitement de l'air intérieur en milieu médical. (Doctoral Dissertation). Ecole nationale supérieure Mines-Télécom Atlantique Bretagne Pays de la Loire. Retrieved from http://www.theses.fr/2018IMTA0112

Chicago Manual of Style (16^th Edition):

Whyte, Henrietta Essie. “Evaluation of the performance of photocatalytic systems for the treatment of indoor air in medical environments : Evaluation de la performance des systèmes photocatalytiques pour le traitement de l'air intérieur en milieu médical.” 2018. Doctoral Dissertation, Ecole nationale supérieure Mines-Télécom Atlantique Bretagne Pays de la Loire. Accessed January 18, 2021. http://www.theses.fr/2018IMTA0112.

MLA Handbook (7^th Edition):

Whyte, Henrietta Essie. “Evaluation of the performance of photocatalytic systems for the treatment of indoor air in medical environments : Evaluation de la performance des systèmes photocatalytiques pour le traitement de l'air intérieur en milieu médical.” 2018. Web. 18 Jan 2021.

Vancouver:

Whyte HE. Evaluation of the performance of photocatalytic systems for the treatment of indoor air in medical environments : Evaluation de la performance des systèmes photocatalytiques pour le traitement de l'air intérieur en milieu médical. [Internet] [Doctoral dissertation]. Ecole nationale supérieure Mines-Télécom Atlantique Bretagne Pays de la Loire; 2018. [cited 2021 Jan 18]. Available from: http://www.theses.fr/2018IMTA0112.

Council of Science Editors:

Whyte HE. Evaluation of the performance of photocatalytic systems for the treatment of indoor air in medical environments : Evaluation de la performance des systèmes photocatalytiques pour le traitement de l'air intérieur en milieu médical. [Doctoral Dissertation]. Ecole nationale supérieure Mines-Télécom Atlantique Bretagne Pays de la Loire; 2018. Available from: http://www.theses.fr/2018IMTA0112

Universiteit Utrecht

22. Metzlar, N. A comparison between the V-gel supra-glottic airway mask and the commonly used cuffed endotracheal tube in spontaneous breathing cats under isoflurane anesthesia.

Degree: 2010, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/252759

► This randomized clinical study compares the use of the endotracheal tube (golden standard) with the new laryngeal mask, the V-gel, in spontaneous breathing cats under… (more)

▼ This randomized clinical study compares the use of the endotracheal tube (golden standard) with the new laryngeal mask, the V-gel, in spontaneous breathing cats under isoflurane anesthesia, in respect to isoflurane leakage, ease of use and irritation of the upper respiratory system after surgery. Material/Methods: All cats were admitted for spaying or castration and were classified as ASA-1 or ASA-2 patient. Ten cats in the V-gel group and eleven cats in the ET-group. The cats premedicated with 20 µg/kg of dexmedetomidine and 15 µg/kg buprenorphine IM. Induction started with propofol, dosed to effect. For analgesic purposes the cats received 0.2 mg/kg metacam before surgery and 0.05mg/kg/day metacam per os by their owners, the first four days following surgery. The following variables were measured: -Required dose of propofol necessary for intubation or placing the V-gel; -Time between induction and recording of a first capnogram in seconds; -Detection of leakage of isoflurane to the environment measured with the Miran 205B Type Saphiree 100 isoflurane analizer; -Post-operative discomfort of the upper respiratory system, subjectively scored by the researcher during the recovery. -Post-operative discomfort of the upper respiratory system, subjectively scored with the owner 24 hours after surgery, by means of a questionnaire. The variables were tested by the Student-T-test and the discomfort was being tested by the Chi-Square test. The level of significance was set to P<0.05. Results: There was no significant difference when comparing the required dose propofol, ET-group (8.29±2.37mg) and V-gel group (6.61±2.93mg). There was a significant difference regarding the time between induction and first reading on the capnometer. Where the V-gel group had a shorter induction time (52.59±30.47sec.) compared to the ET-group (117. 27±27.47sec.). Both groups showed some leakage of the isoflurane, V-gel group (9.89±10.47 mg/m3) and ET-group (9.65±15.09 mg/m3), but no significant difference was found. During recovery six cats from the ET-group were found with an upper airway stridor. According to the Chi-Square test, there were statistically significant fewer cats with an upper airway stridor in the V-gel group (Chi-Square test=7.636364; p=0.005720; df=1).The discomfort scored by the owners showed no significant difference between both groups. Conclusion: The V-gel is easy to use and a good alternative for endotracheal intubation in spontaneous breathing cats under isoflurane anesthesia. Advisors/Committee Members: Oostrom, van, H., Sap, R..

Subjects/Keywords: Diergeneeskunde; V-gel, endotracheal intubation, supra-glottic airway mask, anesthesia, isoflurane lekkage, cats.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Metzlar, N. (2010). A comparison between the V-gel supra-glottic airway mask and the commonly used cuffed endotracheal tube in spontaneous breathing cats under isoflurane anesthesia. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/252759

Chicago Manual of Style (16^th Edition):

Metzlar, N. “A comparison between the V-gel supra-glottic airway mask and the commonly used cuffed endotracheal tube in spontaneous breathing cats under isoflurane anesthesia.” 2010. Doctoral Dissertation, Universiteit Utrecht. Accessed January 18, 2021. http://dspace.library.uu.nl:8080/handle/1874/252759.

MLA Handbook (7^th Edition):

Metzlar, N. “A comparison between the V-gel supra-glottic airway mask and the commonly used cuffed endotracheal tube in spontaneous breathing cats under isoflurane anesthesia.” 2010. Web. 18 Jan 2021.

Vancouver:

Metzlar N. A comparison between the V-gel supra-glottic airway mask and the commonly used cuffed endotracheal tube in spontaneous breathing cats under isoflurane anesthesia. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2010. [cited 2021 Jan 18]. Available from: http://dspace.library.uu.nl:8080/handle/1874/252759.

Council of Science Editors:

Metzlar N. A comparison between the V-gel supra-glottic airway mask and the commonly used cuffed endotracheal tube in spontaneous breathing cats under isoflurane anesthesia. [Doctoral Dissertation]. Universiteit Utrecht; 2010. Available from: http://dspace.library.uu.nl:8080/handle/1874/252759

23. Mattos Júnior, Ewaldo de. Avaliação biespectral, cardiorrespiratória e hemogasométrica em cadelas submetidas a ovariosalpingohisterectomia, tratadas com acepromazina associada ou não a meperidina e anestesiadas com halotano, isofluorano ou sevofluorano.

Degree: Mestrado, Clínica Cirúrgica Veterinária, 2008, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/10/10137/tde-17112008-153956/ ;

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O presente estudo teve como objetivo avaliar os efeitos do halotano, isofluorano e sevofluorano sobre o índice biespectral, parâmetros cardiorrespiratórios e hemogasométricos em cadelas submetidas… (more)

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O presente estudo teve como objetivo avaliar os efeitos do halotano, isofluorano e sevofluorano sobre o índice biespectral, parâmetros cardiorrespiratórios e hemogasométricos em cadelas submetidas a ovariosalpingohisterectomia. Foram utilizadas 48 cadelas, sem raça definida, com peso médio de 15,09±4,29 kg, com idade média de 3,9±1,23 anos, encaminhadas para realização do procedimento de orivariosalpingohisterectomia. Os animais foram distribuídos aleatoriamente em seis grupos de oito animais, sendo designados como AH, AMH, AI, AMI, AS e AMS. Os animais dos grupos AH, AI e AS receberam acepromazina na medicação pré-anestésica na dose de 0,1 mg.kg-1 por via intramuscular. Já os animais dos grupos AMH, AMI e AMS receberam na medicação pré-anestésica acepromazina, na dose de 0,05 mg.kg-1, associada a meperidina, na dose de 3 mg.kg-1, administrados por via intramuscular. A indução da anestesia foi realizada com o auxílio de propofol, na dose de 5 mg.kg-1, lentamente por meio da via intravenosa. Uma vez que os animais apresentaram relaxamento mandibular foi realizada a entubação orotraqueal, sendo em seguida conectada ao circuito valvular circular do aparelho de anestesia, e mantidas em respiração espontânea com halotano (grupos AH e AMH), isofluorano (grupos AI e AMI) ou sevofluorano (grupos AS e AMS), diluídos em oxigênio a 100%. Foram mensurados o índice biespectral (BIS), eletromiografia (EMG), freqüência cardíaca (FC), pressão arterial sistólica (PAS), pressão arterial diastólica (PAD), pressão arterial média (PAM), temperatura retal, freqüência respiratória (FR), tensão de dióxido de carbono no final da expiração (ETCO2), saturação periférica de oxigênio na oxi-hemoglobina (SpO2), relação entra a pressão parcial de oxigênio no sangue arterial e a fração inspirada de oxigênio hemogasometria arterial (pH, PaCO<2, PaO2, HCO3- e DB). Os parâmetros verificados e registrados em todos os grupos desde M0 até M5, sendo estes: M0; 15 minutos após a administração da medicação pré-anestésica, M1; 10 minutos de manutenção anestésica, M2; ligadura do pedículo ovariano direito, M3; sutura da musculatura, M4; sutura de pele, M5; 10 minutos após o fim da administração do anestésico. Em todos os grupos houve forte correlação do índice biespectral e a fração expirada de anestésico. Quanto ao índice biespectral, o grupo AMH apresentou índices inferiores em M2 quando comparado com AI, AMI e AS; neste mesmo momento AI apresentou índices superiores em relação a AMS. Não houve diferença entre os grupos estudados em relação aos parâmetros cardiovasculares. Todos os agentes causaram depressão respiratória, evidenciado pelo incremento na PaCO2, e a ocorrência de acidemia. Conclui-se que os três agentes avaliados possuíram correlação inversa com o índice biespectral, o grupo AMS apresentou valores inferiores de BIS, todos os agentes promoveram estabilidade cardiovascular e de maneira semelhante, desencadearam depressão respiratória e acidemia.

The objective of this study was evaluation effects of the halothane, isoflurane and…

Advisors/Committee Members: Cortopassi, Silvia Renata Gaido.

Subjects/Keywords: Anestesia geral; Cães; Dogs; General anaesthesia; Halotano; Halothane; Isofluorano; Isoflurane; Sevofluorano; Sevoflurane

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mattos Júnior, E. d. (2008). Avaliação biespectral, cardiorrespiratória e hemogasométrica em cadelas submetidas a ovariosalpingohisterectomia, tratadas com acepromazina associada ou não a meperidina e anestesiadas com halotano, isofluorano ou sevofluorano. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/10/10137/tde-17112008-153956/ ;

Chicago Manual of Style (16^th Edition):

Mattos Júnior, Ewaldo de. “Avaliação biespectral, cardiorrespiratória e hemogasométrica em cadelas submetidas a ovariosalpingohisterectomia, tratadas com acepromazina associada ou não a meperidina e anestesiadas com halotano, isofluorano ou sevofluorano.” 2008. Masters Thesis, University of São Paulo. Accessed January 18, 2021. http://www.teses.usp.br/teses/disponiveis/10/10137/tde-17112008-153956/ ;.

MLA Handbook (7^th Edition):

Mattos Júnior, Ewaldo de. “Avaliação biespectral, cardiorrespiratória e hemogasométrica em cadelas submetidas a ovariosalpingohisterectomia, tratadas com acepromazina associada ou não a meperidina e anestesiadas com halotano, isofluorano ou sevofluorano.” 2008. Web. 18 Jan 2021.

Vancouver:

Mattos Júnior Ed. Avaliação biespectral, cardiorrespiratória e hemogasométrica em cadelas submetidas a ovariosalpingohisterectomia, tratadas com acepromazina associada ou não a meperidina e anestesiadas com halotano, isofluorano ou sevofluorano. [Internet] [Masters thesis]. University of São Paulo; 2008. [cited 2021 Jan 18]. Available from: http://www.teses.usp.br/teses/disponiveis/10/10137/tde-17112008-153956/ ;.

Council of Science Editors:

Mattos Júnior Ed. Avaliação biespectral, cardiorrespiratória e hemogasométrica em cadelas submetidas a ovariosalpingohisterectomia, tratadas com acepromazina associada ou não a meperidina e anestesiadas com halotano, isofluorano ou sevofluorano. [Masters Thesis]. University of São Paulo; 2008. Available from: http://www.teses.usp.br/teses/disponiveis/10/10137/tde-17112008-153956/ ;

Universidade do Rio Grande do Sul

24. Adachi, Lauren Naomi Spezia. Avaliação dos efeitos da acupuntura e da eletroacupuntura em modelo animal de dor neuropática : parâmetros comportamentais e bioquímicos.

Degree: 2017, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/169683

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Dor neuropática (DN) é definida como “dor iniciada ou causada por lesão primária ou disfunção em sistema nervoso”, porém sua prevalência depende do tipo de… (more)

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Dor neuropática (DN) é definida como “dor iniciada ou causada por lesão primária ou disfunção em sistema nervoso”, porém sua prevalência depende do tipo de trauma e da disfunção relacionada. Apesar desta condição dolorosa ser considerada altamente prevalente e debilitante, os tratamentos disponíveis são relacionados a efeitos adversos dificultando a adesão. Devido a isso, buscam-se alternativas não farmacológicas para o tratamento deste tipo de dor, entre elas, as técnicas de neuromodulação periférica, como acupuntura (AC) e eletroacupuntura (EA). Estas técnicas podem ser combinadas com intervenções farmacológicas e não farmacológicas e têm apresentado resultados promissores no tratamento da dor neuropática. No entanto, seus mecanismos de ação não estão totalmente elucidados, desta forma a utilização de modelos animais é de grande valia para o estudo destes mecanismos no tratamento da dor neuropática e da patofisiologia deste tipo de dor crônica. É importante salientar que a aplicação de AC e EA em animais acordados é complexa, visto que gera desconforto e pode alterar a analgesia induzida pelo tratamento. Em muitos estudos a anestesia com isoflurano é utilizada durante a aplicação dos tratamentos, porém sua utilização pode gerar um viés no estudo, considerando a possível interferência do fármaco nos resultados comportamentais e neuroquímicos. Outro importante foco de estudo consiste em comparar as duas técnicas, AC e EA, buscando determinar qual destas é a mais eficaz no tratamento da dor neuropática. Considerando o exposto acima, os objetivos desta tese foram: 1) avaliar os parâmetros comportamentais e neuroquímicos dos efeitos da utilização de anestesia na aplicação de AC e EA em ratos submetidos ao modelo de DN; 2) comparar os efeitos da AC e EA em modelo animal de DN por meio de parâmentros comportamentais, neuroquímicos e histológicos. Considerando os resultados obtidos nesta tese, concluímos que o isoflurano aumenta a analgesia promovida por AC e EA, provavelmente diminuindo o efeito do estresse gerado pela aplicação dos tratamentos em animais acordados, resultado que é corroborado pela diminuição do nível de S100β periférico (marcador de morte neuronal central); Por outro lado, o isoflurano diminuiu os níveis de fator de crescimento neuronal (NGF) no nervo periférico lesado, indicando diminuição do processo de regeneração neural, enquanto a EA aumentou. Ao mesmo tempo, o isoflurano alterou os efeitos dos tratamentos nos comportamentos exploratórios e nos níveis de N-metil D-aspartato em tronco encefáfio e medula espinhal. A AC apresentou-se mais eficaz no tratamento da DN em comparação à EA, porém nenhum dos tratamentos foi capaz de alterar os danos causados pela indução da DN no músculo gastrocnemio esquerdo dos animais demonstrado na histologia. Todavia, este resultado não alterou a analgesia gerada pelos tratamentos.

Neuropathic pain (NP) is defined as "pain initiated or caused by primary injury or dysfunction in the nervous system," but its prevalence depends on the type of trauma and related…

Advisors/Committee Members: Torres, Iraci Lucena da Silva.

Subjects/Keywords: Neuralgia; Neuropathic pain; Acupuntura; Acupuncture; Eletroacupuntura; NMDA; S100b; Isoflurano; NGF; Isoflurane; Electroacupuncture

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Adachi, L. N. S. (2017). Avaliação dos efeitos da acupuntura e da eletroacupuntura em modelo animal de dor neuropática : parâmetros comportamentais e bioquímicos. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/169683

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Adachi, Lauren Naomi Spezia. “Avaliação dos efeitos da acupuntura e da eletroacupuntura em modelo animal de dor neuropática : parâmetros comportamentais e bioquímicos.” 2017. Thesis, Universidade do Rio Grande do Sul. Accessed January 18, 2021. http://hdl.handle.net/10183/169683.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Adachi, Lauren Naomi Spezia. “Avaliação dos efeitos da acupuntura e da eletroacupuntura em modelo animal de dor neuropática : parâmetros comportamentais e bioquímicos.” 2017. Web. 18 Jan 2021.

Vancouver:

Adachi LNS. Avaliação dos efeitos da acupuntura e da eletroacupuntura em modelo animal de dor neuropática : parâmetros comportamentais e bioquímicos. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2017. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10183/169683.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Adachi LNS. Avaliação dos efeitos da acupuntura e da eletroacupuntura em modelo animal de dor neuropática : parâmetros comportamentais e bioquímicos. [Thesis]. Universidade do Rio Grande do Sul; 2017. Available from: http://hdl.handle.net/10183/169683

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

25. Linou, Maria. Μελέτη της επίδρασης της αναισθησίας σε νευροεκφυλιστικές παθήσεις του εγκεφάλου: πειραματική μελέτη.

Degree: 2015, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/36408

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The aim of my PhD Thesis was to verify the effects of isoflurane whenthis is used for the anesthesia of mice subjected to permanent occlusion… (more)

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The aim of my PhD Thesis was to verify the effects of isoflurane whenthis is used for the anesthesia of mice subjected to permanent occlusion of themiddle cerebral artery (pMCAO) alone or in combination with a well-knownneuroprotective agent, simvastatin. For this study C57BL/6J mice (n=40) wereselected and were subjected to pMCAO using coagulation. For the anesthesiaketamine/xylazine or isoflurane were used in the absence or presence ofsimvastatin. A comparative analysis among the various experimental groupsbased on quantitative and qualitative analyses was performed in order toevaluate the infarct size and neuronal death within them under the variableexperimental conditions. In summary results showed a similar effect of bothinjectable and inhalational anesthetics used on the size of infarction, and on thenumber of dying neurons within them. The administration of simvastatin had astrong neuroprotective effect as expected that was not affected by the use ofthe two different anesthetics. In conclusion, this study confirmed the safe use ofisoflurane as the preferential anesthetic for this model of ischemic injury in mice,specifically in studies where different neuroprotective agents are assessed inpre-clinical settings of ischemia.

Ο σκοπός της διατριβής αυτής ήταν η διερεύνηση της επίδρασης τουισοφλουράνιου όταν αυτό χρησιμοποιείται για την αναισθησία μυών πουυποβάλλονται σε μόνιμη χειρουργική απόφραξη της μέσης εγκεφαλικήςαρτηρίας (permanent Middle Cerebral Artery Occlusion, pMCAO) μόνο του ήμετά από χορήγηση της νευροπροστατευτικής ουσίας σιμβαστατίνης σταεγκεφαλικά έμφρακτα.Για το σκοπό αυτό επιλέχθηκαν μύες της φυλής C57BL / 6J (n = 40) οιοποίοι υποβλήθηκαν σε χειρουργική μόνιμη απόφραξη της μέσης εγκεφαλικήςαρτηρίας (pMCAO) για την πρόκληση εγκεφαλικής ισχαιμίας. Για τηναναισθησία χρησιμοποιήθηκε είτε μίγμα ενέσιμων αναισθητικών ουσιών,κεταμίνη και ξυλαζίνη είτε εισπνευστικό ισοφλουράνιο, απουσία ή παρουσίασιμβαστατίνης.Ακολούθησε συγκριτική μελέτη των πειραματικών ομάδων με ποιοτικέςκαι ποσοτικές μεθοδολογίες για την αξιολόγηση των ισχαιμικών εμφράκτων καιτον θάνατο των κυττάρων του εγκεφάλου σε αυτά.Συνοπτικά τα αποτελέσματα έδειξαν παρόμοια επίδραση των δύοαναισθητικών σχημάτων στο μέγεθος των εμφράκτων καθώς και στο κυτταρικόθάνατο των νευρώνων εντός αυτών. Η χορήγηση σιμβαστατίνης είχε τοαναμενόμενο νευροπροστατευρικό αποτέλεσμα στο μοντέλο της pMCAO τοοποίο δεν δαφοροποιήθηκε χρησιμοποιώντας κεταμίνη/ξυλαζίνη ή ισοφουράνιο.Συμπερασματικά επιβεβαιώθηκε η ασφαλής χρήση του ισοφλουρανίουως αναισθητικού για την χειρουργική μόνιμη απόφραξη της μέσης εγκεφαλικήςαρτηρίας σε μύες ειδικά σε προκλινικές μελέτες αποτελεσματικότητας νευρο-προστατευτικών ουσιών στις οποίες το ισοφλουράνιο δεν «αλλοιώνει» με τηδράση του την δράση υπό εξέταση πιθανών νευροπροστατευτικών ουσιών.

Subjects/Keywords: Ισοφλουράνιο; Νευροεκφυλιστικές ασθένειες; Εγκεφαλική ισχαιμία; Πειραματική μελέτη; Isoflurane; Brain ischemia; Animal models

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APA (6^th Edition):

Linou, M. (2015). Μελέτη της επίδρασης της αναισθησίας σε νευροεκφυλιστικές παθήσεις του εγκεφάλου: πειραματική μελέτη. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/36408

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Linou, Maria. “Μελέτη της επίδρασης της αναισθησίας σε νευροεκφυλιστικές παθήσεις του εγκεφάλου: πειραματική μελέτη.” 2015. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed January 18, 2021. http://hdl.handle.net/10442/hedi/36408.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Linou, Maria. “Μελέτη της επίδρασης της αναισθησίας σε νευροεκφυλιστικές παθήσεις του εγκεφάλου: πειραματική μελέτη.” 2015. Web. 18 Jan 2021.

Vancouver:

Linou M. Μελέτη της επίδρασης της αναισθησίας σε νευροεκφυλιστικές παθήσεις του εγκεφάλου: πειραματική μελέτη. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2015. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10442/hedi/36408.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Linou M. Μελέτη της επίδρασης της αναισθησίας σε νευροεκφυλιστικές παθήσεις του εγκεφάλου: πειραματική μελέτη. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2015. Available from: http://hdl.handle.net/10442/hedi/36408

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

26. Mariana da Silva Melo. Effect of electroacupunture on female cats (felis catus domesticus) anesthetized with isoflurane and submitted to ovariosalpingohysterectomy.

Degree: 2005, Federal University of Uberlândia

URL: http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=357

►

A acupuntura consiste na inserção de agulhas em pontos específicos do corpo com finalidade terapêutica e analgésica. Dentre os métodos para estimulá-los, a eletroacupuntura (EA)… (more)

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A acupuntura consiste na inserção de agulhas em pontos específicos do corpo com finalidade terapêutica e analgésica. Dentre os métodos para estimulá-los, a eletroacupuntura (EA) destaca-se por promover analgesia com estabilidade cardiorrespiratória, além de reduzir doses de anestésicos. Nesse sentido, objetivou-se com este experimento avaliar o consumo de anestésico e parâmetros cardiorrespiratórios em 20 gatas pré-tratadas com acepromazina, anestesiadas por isofluorano, estimuladas no pré- e transoperatório com EA e submetidas à ovariosalpingohisterectomia eletiva. Os animais foram separados em dois grupos de igual número: G1 (controle) e G2 (eletroacupuntura). Uma vez adquirido o plano anestésico, nas gatas do G1 foram introduzidas agulhas em pontos falsos e o aparelho de eletroestimulação permaneceu desligado; nas do G2, foram introduzidas bilateralmente nos pontos Zusanli (E36) e Yanglingquan (VB34), e a EA foi realizada com freqüências de 2 e 100 Hz, em onda quadrada, com corrente alternada e intensidade variando de 2 a 3 mA iniciando 30 minutos antes de a cirurgia começar e finalizando ao término desta. O estudo foi cego, e como variáveis estudaram-se: consumo de isofluorano, temperatura corpórea, freqüências respiratória e cardíaca, saturação de oxi-hemoglobina e pressão arterial média. Comparativamente ao grupo controle, a EA aumentou a saturação de oxihemoglobina (p<0,05) e reduziu a pressão arterial média (p<0,05); as demais variáveis não diferiram significativamente entre os grupos.

Acupuncture is a way of treating and causing analgesia by inserting needles into the skin at certain points. Among those methods to stimulate such points, electroacupuncture (EA) distinguishes itself because it causes preemptive analgesia with cardiorespiratory stability and reduces anesthetic dosage. In this regard, the goal of this work was to evaluate anesthetic consumption and cardiorespiratory parameters in 20 female cats pretreated with acepromazine, anesthetized with isoflurane, stimulated in the pre- and transoperative periods with EA, and submitted to elective ovariosalpingohysterectomy. The cats were gathered into two groups: G1 (control) and G2 (electroacupuncture). Once reached the steadystate level, needles were inserted at false points along the G1 cats body, with the electrostimulation device being kept off. Regarding the G2 cats, needles were bilaterally inserted at the points Zusanli (ST36) and Yanglingquan (GB34), with electroacupuncture being performed at frequencies of 2 and 100 Hz, in square wave, with alternating current, and intensity ranging from 2 to 3 mA; it begun 30 minutes prior to the surgery and lasted till the end of the latter. In this double-blind study, variables studied were isoflurane consumption, body temperature, respiratory and heart rate, oxyhemoglobin saturation, and mean arterial pressure. Comparatively with the control group, electroacupuncture increased oxyhemoglobin saturation (p<0,05) and reduced mean arterial pressure (p<0,05). There was no relevant difference between G1 and G2…

Advisors/Committee Members: Stelio Pacca Loureiro Luna, Hudson Armando Nunes Canabrava, Magda Alves de Medeiros, Cirilo Antonio de Paula Lima.

Subjects/Keywords: Eletroacupuntura; Gatos; Isofluorano; Yanglingquan; Zusanli; Acupuntura veterinária; MEDICINA VETERINARIA; Electroacupuncture; Cats; Isoflurane; Yanglingquan; Zusanli

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Melo, M. d. S. (2005). Effect of electroacupunture on female cats (felis catus domesticus) anesthetized with isoflurane and submitted to ovariosalpingohysterectomy. (Thesis). Federal University of Uberlândia. Retrieved from http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=357

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Melo, Mariana da Silva. “Effect of electroacupunture on female cats (felis catus domesticus) anesthetized with isoflurane and submitted to ovariosalpingohysterectomy.” 2005. Thesis, Federal University of Uberlândia. Accessed January 18, 2021. http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=357.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Melo, Mariana da Silva. “Effect of electroacupunture on female cats (felis catus domesticus) anesthetized with isoflurane and submitted to ovariosalpingohysterectomy.” 2005. Web. 18 Jan 2021.

Vancouver:

Melo MdS. Effect of electroacupunture on female cats (felis catus domesticus) anesthetized with isoflurane and submitted to ovariosalpingohysterectomy. [Internet] [Thesis]. Federal University of Uberlândia; 2005. [cited 2021 Jan 18]. Available from: http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=357.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Melo MdS. Effect of electroacupunture on female cats (felis catus domesticus) anesthetized with isoflurane and submitted to ovariosalpingohysterectomy. [Thesis]. Federal University of Uberlândia; 2005. Available from: http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=357

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

27. Ãtila Costa. PinÃamento digital e estÃmulo elÃtrico na determinaÃÃo da ConcentraÃÃo AnestÃsica MÃnima (CAM) de isofluorano em galinhas prÃtratadas ou nÃo com meloxicam.

Degree: 2009, Universidade do Estado de Santa Catarina

URL: http://www.tede.udesc.br/tde_busca/arquivo.php?codArquivo=3358

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The toe pinch has been the nociceptive stimuli in determining the minimum anesthetic concentration (MAC) in birds. In mammals electrical simulation has been used with… (more)

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The toe pinch has been the nociceptive stimuli in determining the minimum anesthetic concentration (MAC) in birds. In mammals electrical simulation has been used with high accuracy and repeatability. The non steroid anti-inflammatory meloxicam, has been used safely in birds, but its efficacy and safety during anesthesia, is still unknown. Thirty chickens (Gallus gallus) healthy, same batch, age 30 to 45 weeks, and weight of 1.733 Â 266kg, were randomly allocated into five groups, respecting an interval of at least 10 days in birds reused. In the first part, were assessed two types of nociceptive stimulation for CAM determination, the toe pinch (P), and two forms of electrical stimulation (30mA; 50Hz); aluminium plates on the foot (E1), and hypodermic needles in the leg (E2). In the second part, we evaluated the CAM birds pre-treated with meloxicam (0.5 mg / kg, IM, 15 min. before induction), using the toe pinch (MP) and electrical stimulation with needles (ME), both about 60 minutes after meloxicam. After 15 minutes for equilibration the anestetic concentration, arterial blood gases, and cardiorespiratory parameters were obtained before and after the nociceptive stimuli. The CAM determination was through the upand- down method. Was considered significant when p <0,05. The MAC of isoflurane in group P was 1.11 Â 0.08% in E1 0.92 Â 0.21%, and E2 1.47 Â 0.10%. In the groups pre-treated with meloxicam, MP was 0.75 Â 0.08%, 32% less than P (p <0.001), and ME was 1.27 Â 0.02%, 14% to E2 (p <0.001). The stimulus in E2 was the most intense (supramaximal) and validated in the determination of MAC in birds. The toe pinch, although not supramaximal, obtained an similar precision to E2, when not pretreated. The stimulus in E1 was considered invalid. Chickens when pre-treated with meloxicam had lower values of CAM

O pinÃamento de dedo tem sido o estimulo nociceptivo na determinaÃÃo da concentraÃÃo anestÃsica mÃnima (CAM) em aves. Em mamÃferos o estÃmulo elÃtrico tem sido utilizado, buscando maior acurÃcia e repetibilidade. O anti-inflamatÃrio nÃo esteroidal meloxicam, tem sido utilizado com seguranÃa em aves, porÃm sua eficÃcia e seguranÃa durante anestesia inalatÃria, ainda Ã desconhecida. Trinta galinhas (Gallus gallus) saudÃveis, de mesmo lote, idade de 30 a 45 semanas, e peso de 1,733 Â 266kg, foram alocadas aleatoriamente em cinco grupos, sempre respeitando um intervalo de no mÃnimo 10 dias nas aves reutilizadas. Na primeira parte, foram avaliadas duas modalidades de estimulaÃÃo nociceptiva para determinaÃÃo de CAM; o pinÃamento de dedo (P), e duas formas de estÃmulo elÃtrico (30mA;50Hz), placas de alumÃnio na pata (E1), e agulhas hipodÃrmicas na coxa (E2). Na segunda parte, foi avaliada a CAM de aves prÃ-tratadas com meloxicam (0,5 mg/kg;IM;15 min. antes induÃÃo), utilizando o pinÃamento de dedo (MP), e estÃmulo elÃtrico com agulhas (ME), ambos aproximadamente 60 minutos apÃs meloxicam. ApÃs 15 minutos para equilÃbrio da concentraÃÃo anestÃsica, parÃmetros cardiorrespiratÃrios e hemogasomÃtricos foram obtidos antes, e…

Advisors/Committee Members: Aury Nunes de Moraes.

Subjects/Keywords: CAM; aves; estÃmulo elÃtrico; meloxicam; isofluorano; MAC; birds; eletrical stimulation; meloxicam; isoflurane; MEDICINA VETERINARIA

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Costa, �. (2009). PinÃamento digital e estÃmulo elÃtrico na determinaÃÃo da ConcentraÃÃo AnestÃsica MÃnima (CAM) de isofluorano em galinhas prÃtratadas ou nÃo com meloxicam. (Thesis). Universidade do Estado de Santa Catarina. Retrieved from http://www.tede.udesc.br/tde_busca/arquivo.php?codArquivo=3358

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Costa, Ãtila. “PinÃamento digital e estÃmulo elÃtrico na determinaÃÃo da ConcentraÃÃo AnestÃsica MÃnima (CAM) de isofluorano em galinhas prÃtratadas ou nÃo com meloxicam.” 2009. Thesis, Universidade do Estado de Santa Catarina. Accessed January 18, 2021. http://www.tede.udesc.br/tde_busca/arquivo.php?codArquivo=3358.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Costa, Ãtila. “PinÃamento digital e estÃmulo elÃtrico na determinaÃÃo da ConcentraÃÃo AnestÃsica MÃnima (CAM) de isofluorano em galinhas prÃtratadas ou nÃo com meloxicam.” 2009. Web. 18 Jan 2021.

Vancouver:

Costa �. PinÃamento digital e estÃmulo elÃtrico na determinaÃÃo da ConcentraÃÃo AnestÃsica MÃnima (CAM) de isofluorano em galinhas prÃtratadas ou nÃo com meloxicam. [Internet] [Thesis]. Universidade do Estado de Santa Catarina; 2009. [cited 2021 Jan 18]. Available from: http://www.tede.udesc.br/tde_busca/arquivo.php?codArquivo=3358.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Costa �. PinÃamento digital e estÃmulo elÃtrico na determinaÃÃo da ConcentraÃÃo AnestÃsica MÃnima (CAM) de isofluorano em galinhas prÃtratadas ou nÃo com meloxicam. [Thesis]. Universidade do Estado de Santa Catarina; 2009. Available from: http://www.tede.udesc.br/tde_busca/arquivo.php?codArquivo=3358

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université Laval

28. Ferron, Judy-Fay. Étude in vivo du "burst-suppression".

Degree: 2009, Université Laval

URL: http://hdl.handle.net/20.500.11794/21020

►

Tableau d’honneur de la Faculté des études supérieures et postdoctorales, 2009-2010

Cette étude résume certains concepts liés à l’anesthésie générale, détaille les mécanismes d’action de… (more)

Subjects/Keywords: Isoflurane – Mécanisme d'action; Inhibition (Neurophysiologie); Anesthésie

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ferron, J. (2009). Étude in vivo du "burst-suppression". (Thesis). Université Laval. Retrieved from http://hdl.handle.net/20.500.11794/21020

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ferron, Judy-Fay. “Étude in vivo du "burst-suppression".” 2009. Thesis, Université Laval. Accessed January 18, 2021. http://hdl.handle.net/20.500.11794/21020.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ferron, Judy-Fay. “Étude in vivo du "burst-suppression".” 2009. Web. 18 Jan 2021.

Vancouver:

Ferron J. Étude in vivo du "burst-suppression". [Internet] [Thesis]. Université Laval; 2009. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/20.500.11794/21020.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ferron J. Étude in vivo du "burst-suppression". [Thesis]. Université Laval; 2009. Available from: http://hdl.handle.net/20.500.11794/21020

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Gothenburg / Göteborgs Universitet

29. Jonatan, Oras. Stress-induced cardiomyopathy - clinical and experimental studies.

Degree: 2015, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/39562

► Background: Stress-induced cardiomyopathy (SIC) is an acute cardiac condition with akinesia in the left ventricle (LV) that can be severe. A stress-trigger, physical or emotional,… (more)

▼ Background: Stress-induced cardiomyopathy (SIC) is an acute cardiac condition with akinesia in the left ventricle (LV) that can be severe. A stress-trigger, physical or emotional, is usually identified preceding onset of symptoms and catecholamine overstimulation is involved in the pathogenesis of SIC. The akinesia seen in SIC is reversible and the short term prognosis is therefore considered to be very good. However, recent data suggest that the long term prognosis is equivalent to patients suffering from myocardial infarction. Physical triggers and critical illness are the major triggers of SIC and specially patients with subarachnoid hemorrhage (SAH) frequently develop SIC. Patients with SIC after SAH have an increased risk of secondary cerebral infarction and have a worse short-term prognosis. Aim: The aim was to evaluate if the biomarkers of myocardial injury (hsTNT) and cardiac dysfunction (NTproBNP) could be used for identification of patients with SIC after SAH and if patients with increased levels of hsTnT and NTproBNP had an increased risk of poor long-term prognosis (Paper I, II). In an experimental animal model of SIC, the aim was to evaluate cardioprotective properties of different anesthetics (Paper III, IV). Methods: The first study (Paper I) was retrospective. Data was collected from all patients admitted to the NICU, Sahlgrenska University Hospital, during almost five years. Patients with an echocardiography performed and the biomarkers hsTnT or NTproBNP were obtained were included in the analysis. The second study (Paper II) was prospective. All consecutive patients admitted to the NICU, Sahlgrenska University Hospital, during two years were enrolled in the study. hsTnT and NTproBNP were taken on admission and the three following days and clinical data were obtained. Follow-up was performed one year after onset of symptoms. In Paper III and IV, SIC was induced with an intraperitoneal bolus of isoprenaline in Sprague Dawley rats. Different anesthetics were applied prior to induction of SIC. Vital parameters were measured and small animal echocardiography was performed. A proteomic analysis was performed for assessment of cardioprotective pathways. Results: Patients with SIC after SAH could be identified with the cardiac biomarkers hsTnT and NTproBNP (Paper I). Increased levels of hsTnT were independently associated with a higher risk of poor long-term outcome when adjusted for age, neurological status on admission and cerebral infarction. Increased levels of hsTnT and NTproBNP was associated with a higher risk of delayed cerebral infarction (Paper II). In the experimental studies, isoflurane had a cardioprotective dose-response effect while propofol and ketamine were not cardioprotective. The cardioprotective mechanism was not mediated through anesthesia per se, by reducing myocardial oxygen demand or by activating the mKatp-channels described in anesthetic preconditioning. In a proteomic analysis, we found that isoflurane attenuated virtually all the pathogenic pathways induced in SIC. Isoflurane…

Subjects/Keywords: Stress-induced cardiomyopathy; Subarachnoid hemorrhage; tako-tsubo; isoflurane; outcome; cerebral infarction; hsTnT; NTproBNP; proteomics; bioinformatics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jonatan, O. (2015). Stress-induced cardiomyopathy - clinical and experimental studies. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/39562

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jonatan, Oras. “Stress-induced cardiomyopathy - clinical and experimental studies.” 2015. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed January 18, 2021. http://hdl.handle.net/2077/39562.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jonatan, Oras. “Stress-induced cardiomyopathy - clinical and experimental studies.” 2015. Web. 18 Jan 2021.

Vancouver:

Jonatan O. Stress-induced cardiomyopathy - clinical and experimental studies. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2015. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2077/39562.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jonatan O. Stress-induced cardiomyopathy - clinical and experimental studies. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2015. Available from: http://hdl.handle.net/2077/39562

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Virginia Tech

30. Wood, Melinda Anne. The Effects of Anesthesia and Surgery on Thyroid Function Tests in Dogs.

Degree: MS, Biomedical and Veterinary Sciences, 2007, Virginia Tech

URL: http://hdl.handle.net/10919/43705

► Background: Many non-thyroidal factors affect thyroid function tests. Anesthesia and surgery have been documented to affect thyroid function tests in humans but have not been… (more)

Subjects/Keywords: non-thyroidal illness; isoflurane; hypothyroidism; Thyroxine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wood, M. A. (2007). The Effects of Anesthesia and Surgery on Thyroid Function Tests in Dogs. (Masters Thesis). Virginia Tech. Retrieved from http://hdl.handle.net/10919/43705

Chicago Manual of Style (16^th Edition):

Wood, Melinda Anne. “The Effects of Anesthesia and Surgery on Thyroid Function Tests in Dogs.” 2007. Masters Thesis, Virginia Tech. Accessed January 18, 2021. http://hdl.handle.net/10919/43705.

MLA Handbook (7^th Edition):

Wood, Melinda Anne. “The Effects of Anesthesia and Surgery on Thyroid Function Tests in Dogs.” 2007. Web. 18 Jan 2021.

Vancouver:

Wood MA. The Effects of Anesthesia and Surgery on Thyroid Function Tests in Dogs. [Internet] [Masters thesis]. Virginia Tech; 2007. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10919/43705.

Council of Science Editors:

Wood MA. The Effects of Anesthesia and Surgery on Thyroid Function Tests in Dogs. [Masters Thesis]. Virginia Tech; 2007. Available from: http://hdl.handle.net/10919/43705

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