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You searched for subject:(intravenous lipid emulsion). One record found.

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University of Illinois – Chicago

1. Kuo, Ilin. Exploring the ‘Lipid Sink’ as a mechanism for Reversal of Local Anesthetic Toxicity:A PBPK Modeling Study.

Degree: 2012, University of Illinois – Chicago

Intravenous lipid emulsions (ILE) have been demonstrated to be effective mitigators of systemic toxicity caused by drug overdose, with dramatic resuscitations observed in small animals and clinical settings. The prevailing theory as to their method of action is known as the ‘lipid sink’. The theory proposes that intravenous lipid droplets create a discrete hydrophobic phase in the blood stream into which lipophilic drugs preferentially partition. This partitioning is thought to reduce the quantity of drug that is accessible to tissues and thereby reduce the drug content of tissues in vital organs such as the heart. The objective of this work is to explore the validity of the proposed mechanism by quantitatively evaluating the impact of a sequestering droplet on the exposure of vital organs to acutely toxic concentrations of drug. This is achieved by: (i) development of a predictive physiologically based pharmacokinetic model for the study of the distribution, metabolism, and elimination of the local anesthetic bupivacaine; (ii) extension of the model to simulation of bupivacaine overdose and administration of intravenous lipid; (iii) assessment of the potential efficacy of a ‘lipid sink’ with regard to reducing tissue exposure to the anesthetic. The output of the model confirmed drug redistribution from tissues to the blood stream as an effect of the ‘lipid sink’ mechanism. It was observed that the efficacy of a lipid scavenger depends on a number of factors such as the lipid metabolism and the treatment regimen. Depending on the rate of lipid metabolism, ILE may cause a reduction in tissue exposure as low as 5% or as high as 35%. The model also predicts that ILE treatment is most effective when started early. The initial concentration drop in the heart tissue can be as high as 20% (5 minute treatment delay) or <10% (20 minute delay) Given the dramatic recoveries observed clinically, ILE therapy is clearly effective, but it is not clear that the sink mechanism is the primary mechanism of action (in the case of bupivacaine toxicity). Advisors/Committee Members: Akpa, Belinda S (advisor).

Subjects/Keywords: Lipid rescue; lipid emulsion; lipid sink; bupivacaine; PBPK; drug overdose; intravenous lipid emulsion; intralipid

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Kuo, I. (2012). Exploring the ‘Lipid Sink’ as a mechanism for Reversal of Local Anesthetic Toxicity:A PBPK Modeling Study. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/9151

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Kuo, Ilin. “Exploring the ‘Lipid Sink’ as a mechanism for Reversal of Local Anesthetic Toxicity:A PBPK Modeling Study.” 2012. Thesis, University of Illinois – Chicago. Accessed October 21, 2019. http://hdl.handle.net/10027/9151.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Kuo, Ilin. “Exploring the ‘Lipid Sink’ as a mechanism for Reversal of Local Anesthetic Toxicity:A PBPK Modeling Study.” 2012. Web. 21 Oct 2019.

Vancouver:

Kuo I. Exploring the ‘Lipid Sink’ as a mechanism for Reversal of Local Anesthetic Toxicity:A PBPK Modeling Study. [Internet] [Thesis]. University of Illinois – Chicago; 2012. [cited 2019 Oct 21]. Available from: http://hdl.handle.net/10027/9151.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kuo I. Exploring the ‘Lipid Sink’ as a mechanism for Reversal of Local Anesthetic Toxicity:A PBPK Modeling Study. [Thesis]. University of Illinois – Chicago; 2012. Available from: http://hdl.handle.net/10027/9151

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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