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You searched for subject:(intra sensory). Showing records 1 – 2 of 2 total matches.

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University of Kansas

1. Pan, Pan. Differential expression of neuregulin-1 isoforms and downregulation of erbin are associated with Erb B2 receptor activation in diabetic peripheral neuropathy.

Degree: PhD, Pharmacology & Toxicology, 2014, University of Kansas

Aberrant neuron-glia interactions can contribute to a variety of neurodegenerative diseases. We have previously demonstrated that enhanced activation of Erb B2, which is a member of the epidermal growth factor receptor (EGFR) family, can contribute to the development of diabetic peripheral neuropathy (DPN). In peripheral nerves, Erb B receptors are activated by various members of the neuregulin-1 (NRG1) family including NRG1 Type I, NRG1 Type II and NRG1 Type III to regulate Schwann cell growth, migration, differentiation and dedifferentiation. Alternatively, Erb B2 activity can be negatively regulated by association with the Erb B2-interacting protein, erbin. Since the effect of diabetes on the expression of NRG1 isoforms and erbin in peripheral nerve are unknown, the current study determined whether changes in NRG1 isoforms and erbin may be associated with altered Erb B2 signaling in DPN. Swiss Webster mice were rendered diabetic with streptozotocin (STZ) and after 12 weeks of diabetes, treated with erlotinib, an inhibitor of Erb B2 activation. Inhibition of Erb B2 signaling partially reversed several pathophysiologic aspects of DPN including a pronounced sensory hypoalgesia, nerve conduction velocity deficits and the decrease in epidermal nerve fiber innervation. We also observed a decrease of NRG1 Type III but an increase of NRG1 Type I level in diabetic sural nerves at early stage of diabetes. With disease progression, we detected reduced erbin expression and enhanced MAPK pathway activity in diabetic mice. Pharmacologic inhibition of Erb B2 suppressed MAPK activity in diabetic sural nerves. These results support that hyperglycemia may impair NRG1-Erb B2 signaling by disrupting the balance between NRG1 isoforms, decreasing the expression of erbin and correspondingly activating the MAPK pathway. Together, imbalanced NRG1 isoforms and downregulated erbin may contribute to the dysregulation of Erb B2 signaling in the development of DPN Advisors/Committee Members: Dobrowsky, Rick T (advisor), Staudinger, Jeff L (cmtemember), Moise, Alexander R (cmtemember), Shi, Honglian (cmtemember), Ackley, Brian D (cmtemember).

Subjects/Keywords: Pharmacology; Erlotinib; Intra epidermal nerve fibers; Nerve conduction velocity; Sensory hypoalgesia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Pan, P. (2014). Differential expression of neuregulin-1 isoforms and downregulation of erbin are associated with Erb B2 receptor activation in diabetic peripheral neuropathy. (Doctoral Dissertation). University of Kansas. Retrieved from http://hdl.handle.net/1808/21637

Chicago Manual of Style (16th Edition):

Pan, Pan. “Differential expression of neuregulin-1 isoforms and downregulation of erbin are associated with Erb B2 receptor activation in diabetic peripheral neuropathy.” 2014. Doctoral Dissertation, University of Kansas. Accessed June 26, 2019. http://hdl.handle.net/1808/21637.

MLA Handbook (7th Edition):

Pan, Pan. “Differential expression of neuregulin-1 isoforms and downregulation of erbin are associated with Erb B2 receptor activation in diabetic peripheral neuropathy.” 2014. Web. 26 Jun 2019.

Vancouver:

Pan P. Differential expression of neuregulin-1 isoforms and downregulation of erbin are associated with Erb B2 receptor activation in diabetic peripheral neuropathy. [Internet] [Doctoral dissertation]. University of Kansas; 2014. [cited 2019 Jun 26]. Available from: http://hdl.handle.net/1808/21637.

Council of Science Editors:

Pan P. Differential expression of neuregulin-1 isoforms and downregulation of erbin are associated with Erb B2 receptor activation in diabetic peripheral neuropathy. [Doctoral Dissertation]. University of Kansas; 2014. Available from: http://hdl.handle.net/1808/21637


Utah State University

2. Pounds, David L. Inter- and Intra-sensory Modality Stimulus Scaling: A Method for the Determination of the Relative Salience of Stimuli in Poison-based Aversion Learning by Pigeons.

Degree: PhD, Psychology, 1981, Utah State University

One of the most rapidly expanding areas of research in psychology has been poison-based aversion learning (PBAL). The PBAL paradigm typically involves: exposing an animal to a novel substance; inducing illness following ingestion of that substance; and then providing access to the substance at a later time. The initial reaction to the novel substance is generally to reduce consumption, a finding labeled neophobia. The reduction of substance intake on test day is called learned aversion. Following demonstrations of cue-to-consequence specificity (i.e., the differential associability of some stimuli with certain consequences) in PBAL research with rats, recent research has focused on PBAL by avians. Such research has been instigated by speculation that avians might be specially adapted to better associate visual rather than flavor stimuli with illness. Studies to determine the relative salience of visual or flavor cues in avian PBAL have reported contradictory findings. A number of methodological differences exist between these studies including differences in stimulus intensity and type, duration between conditioning and assessment, and method of assessment. The current series of experiments made several methodological improvements to clarify the issue of cue to consequence specificity in PBAL with avians. Three experiments with pigeons as subjects are reported. The first experiment equated (scaled) stimulus intensity across different sense modalities by equating neophobic responses to various concentrations of salt, sour, and red water. The second experiment determined the extended effects of the illness-inducing stimulus alone on fluid consumption by pigeons in a restricted access to water environment. The third experiment was based upon results from the first two experiments and assessed aversion, at two different post-injection times, to one of two concentrations of either salt, sour, or red water CSs. In addition, a compound (flavor plus color) conditioning group was employed. Aversion was a function of flavor or color stimulus intensity. No differences were observed in degree of aversion demonstrated by groups receiving stimuli equated for initial suppression. Evidence for overshadowing or potentiation was not found. The results support the position that neither flavor or color stimuli are necessarily the most salient in avian PBAL. Advisors/Committee Members: Carl D. Cheney, ;.

Subjects/Keywords: inter-sensory; intra-sensory; modality; stimulus; salience; poison; aversion; pigeons; Psychology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Pounds, D. L. (1981). Inter- and Intra-sensory Modality Stimulus Scaling: A Method for the Determination of the Relative Salience of Stimuli in Poison-based Aversion Learning by Pigeons. (Doctoral Dissertation). Utah State University. Retrieved from https://digitalcommons.usu.edu/etd/5898

Chicago Manual of Style (16th Edition):

Pounds, David L. “Inter- and Intra-sensory Modality Stimulus Scaling: A Method for the Determination of the Relative Salience of Stimuli in Poison-based Aversion Learning by Pigeons.” 1981. Doctoral Dissertation, Utah State University. Accessed June 26, 2019. https://digitalcommons.usu.edu/etd/5898.

MLA Handbook (7th Edition):

Pounds, David L. “Inter- and Intra-sensory Modality Stimulus Scaling: A Method for the Determination of the Relative Salience of Stimuli in Poison-based Aversion Learning by Pigeons.” 1981. Web. 26 Jun 2019.

Vancouver:

Pounds DL. Inter- and Intra-sensory Modality Stimulus Scaling: A Method for the Determination of the Relative Salience of Stimuli in Poison-based Aversion Learning by Pigeons. [Internet] [Doctoral dissertation]. Utah State University; 1981. [cited 2019 Jun 26]. Available from: https://digitalcommons.usu.edu/etd/5898.

Council of Science Editors:

Pounds DL. Inter- and Intra-sensory Modality Stimulus Scaling: A Method for the Determination of the Relative Salience of Stimuli in Poison-based Aversion Learning by Pigeons. [Doctoral Dissertation]. Utah State University; 1981. Available from: https://digitalcommons.usu.edu/etd/5898

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