subject:(inflammation macrophage masseter mast muscle temporomandibular)

University of Florida

1. Harris, Allison. Does an Altered Inflammatory Response Have a Role in Delayed Masseter Muscle Repair?.

Degree: MS, Dental Sciences - Dentistry, 2010, University of Florida

Subjects/Keywords: Cell growth; Cytokines; Healing; Inflammation; Macrophages; Mast cells; Masticatory muscles; Muscle tissues; Muscles; Pain; inflammation, macrophage, masseter, mast, muscle, temporomandibular

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Harris, A. (2010). Does an Altered Inflammatory Response Have a Role in Delayed Masseter Muscle Repair?. (Masters Thesis). University of Florida. Retrieved from https://ufdc.ufl.edu/UFE0041443

Chicago Manual of Style (16^th Edition):

Harris, Allison. “Does an Altered Inflammatory Response Have a Role in Delayed Masseter Muscle Repair?.” 2010. Masters Thesis, University of Florida. Accessed January 21, 2021. https://ufdc.ufl.edu/UFE0041443.

MLA Handbook (7^th Edition):

Harris, Allison. “Does an Altered Inflammatory Response Have a Role in Delayed Masseter Muscle Repair?.” 2010. Web. 21 Jan 2021.

Vancouver:

Harris A. Does an Altered Inflammatory Response Have a Role in Delayed Masseter Muscle Repair?. [Internet] [Masters thesis]. University of Florida; 2010. [cited 2021 Jan 21]. Available from: https://ufdc.ufl.edu/UFE0041443.

Council of Science Editors:

Harris A. Does an Altered Inflammatory Response Have a Role in Delayed Masseter Muscle Repair?. [Masters Thesis]. University of Florida; 2010. Available from: https://ufdc.ufl.edu/UFE0041443

2. Silva, Ana Maria Bettoni Rodrigues da. Efeito do uso da placa oclusal resiliente em indivíduos portadores de disfunção temporomandibular - avaliação clínica e eletromiográfica.

Degree: PhD, Reabilitação Oral, 2009, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/58/58131/tde-26032010-093748/ ;

► Para melhor compreender a fisiopatologia que afeta a musculatura do sistema estomatognático, a análise eletromiográfica dos músculos da mastigação tem sido incluída em muitos estudos.… (more)

▼ Para melhor compreender a fisiopatologia que afeta a musculatura do sistema estomatognático, a análise eletromiográfica dos músculos da mastigação tem sido incluída em muitos estudos. A eletromiografia (EMG) permite verificar e avaliar a eficácia muscular, entre os músculos de ambos os lados do corpo (simetria) e entre pares de músculos, com um possível efeito de desvio lateral da mandíbula (torque) (Ferrario et al., 1999, 2002). O objetivo desse trabalho foi estudar por meio da EMG de superfície os músculos masseter (porção superficial) e temporal (porção anterior) bilateralmente, e verificar o efeito do uso da placa oclusal resiliente, como um dos recursos para o tratamento das desordens temporomandibulares (DTMs), e comparar com um grupo controle. Foram envolvidos 23 indivíduos com sinais e sintomas de DTM, avaliados clinicamente, que receberam depois tratamento com placas oclusais resilientes. Para estabelecer a presença ou ausência de DTM, foi utilizado o Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD); além de registrar a atividade EMG dos músculos masseter e temporal, bilateralmente, antes (inicial Etapa 1), 30 (Etapa 2) e 60 dias após o uso da placa oclusal resiliente (Etapa 3) (Pettengill et al., 1998); relacionar os achados eletromiográficos com a avaliação clínica da oclusão e das funções estomatognáticas; comparar os resultados de uma população com DTM e o grupo controle de 23 indivíduos. As avaliações EMG foram registradas por meio de movimentos de mastigação e das condições clínicas de repouso, lateralidade com contato bilateral, protrusão e apertamento dental. A análise estatística foi realizada com o emprego do software SPSS versão 15.0 (Chicago, IL, USA). Devido ao fato de que foi rejeitada a hipótese de normalidade da grande maioria das variáveis (Teste de Shapiro-Wilks) foram utilizados métodos não-paramétricos na análise. O nível de significância adotado foi p ≤0,05. Os dados dos grupos controle e DTM foram comparados por meio do teste não-paramétrico de Mann-Whitney, e as comparações intragrupo DTM (inicial, 30 e 60 dias de uso de placa) foram realizadas por meio do teste não-paramétrico de Wilcoxon. De acordo com os resultados, na condição clínica de repouso, não houve diferença estatisticamente significativa na comparação entre os grupos controle e DTM; e foi observado diferença estatisticamente significativa intra-grupo de DTM. Na condição clínica de lateralidade direita, houve diferença estatisticamente significativa na comparação entre os grupos controle e DTM, e na comparação intra-grupo de DTM, não houve diferença estatisticamente significativa. Entretanto, na condição clínica de lateralidade esquerda, não houve diferença estatisticamente significativa na comparação entre os grupos controle e DTM, e na comparação intra-grupo DTM. Na condição clínica de protrusão, na comparação entre os grupos controle e DTM, e na comparação intra-grupo de DTM, houve diferença estatisticamente significativa. Na condição clínica de apertamento de parafilme, houve diferença… Advisors/Committee Members: Vitti, Mathias.

Subjects/Keywords: disfunção temporomandibular; electromyography; eletromiografia; masseter muscle; músculo masseter; músculo temporal; occlusal splint; placa oclusal; temporal muscle; temporomandibular dysfunction

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Silva, A. M. B. R. d. (2009). Efeito do uso da placa oclusal resiliente em indivíduos portadores de disfunção temporomandibular - avaliação clínica e eletromiográfica. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/58/58131/tde-26032010-093748/ ;

Chicago Manual of Style (16^th Edition):

Silva, Ana Maria Bettoni Rodrigues da. “Efeito do uso da placa oclusal resiliente em indivíduos portadores de disfunção temporomandibular - avaliação clínica e eletromiográfica.” 2009. Doctoral Dissertation, University of São Paulo. Accessed January 21, 2021. http://www.teses.usp.br/teses/disponiveis/58/58131/tde-26032010-093748/ ;.

MLA Handbook (7^th Edition):

Silva, Ana Maria Bettoni Rodrigues da. “Efeito do uso da placa oclusal resiliente em indivíduos portadores de disfunção temporomandibular - avaliação clínica e eletromiográfica.” 2009. Web. 21 Jan 2021.

Vancouver:

Silva AMBRd. Efeito do uso da placa oclusal resiliente em indivíduos portadores de disfunção temporomandibular - avaliação clínica e eletromiográfica. [Internet] [Doctoral dissertation]. University of São Paulo; 2009. [cited 2021 Jan 21]. Available from: http://www.teses.usp.br/teses/disponiveis/58/58131/tde-26032010-093748/ ;.

Council of Science Editors:

Silva AMBRd. Efeito do uso da placa oclusal resiliente em indivíduos portadores de disfunção temporomandibular - avaliação clínica e eletromiográfica. [Doctoral Dissertation]. University of São Paulo; 2009. Available from: http://www.teses.usp.br/teses/disponiveis/58/58131/tde-26032010-093748/ ;

3. Heng, Patrick. Characterisation of macrophage capping protein as a novel inflammatory mediator.

Degree: 2017, University of Melbourne

URL: http://hdl.handle.net/11343/191467

► Immune cells such as mast cells and macrophages play important roles in initiating, perpetuating, and resolving inflammation. These cells release soluble factors that mediate the… (more)

▼ Immune cells such as mast cells and macrophages play important roles in initiating, perpetuating, and resolving inflammation. These cells release soluble factors that mediate the common features of inflammation in both health and disease. Whilst many mediators have been identified and characterised, the function of other released mediators remains unclear. Preliminary studies in our laboratory have identified macrophage capping protein (CapG) as a novel factor released from mast cells. Intracellular CapG is known to be a regulator of actin polymerisation. However, extracellular CapG is also known to be constitutively secreted from resting macrophages and found to be elevated in inflammatory disorders such as rheumatoid arthritis. However, the function of this protein at the extracellular level remains unclear. We hypothesised that CapG is a novel inflammatory mediator that contributes to inflammation. The main findings of this thesis are as below: 1. CapG is predominantly expressed intracellularly in immune cells in both primary and immortalised macrophages and mast cell lines. 2. CapG is released from activated mast cells and macrophages, including microglia. Furthermore, release of CapG from LPS-stimulated macrophages is mediated through TLR4 and is modulated by the anti-inflammatory glucocorticoid dexamethasone. 3. Messenger RNA levels of CapG are downregulated in LPS-stimulated macrophages. However, CapG message levels are elevated in tissue samples obtained from mouse models of inflammation, as well as in human brain samples obtained from post-mortem Alzheimer’s disease sufferers. 4. To facilitate an examination of the extracellular role of CapG, we have developed a human CapG mammalian expression system that was functionally validated using actin polymerisation assays. 5. Recombinant CapG was shown to significantly induce pro-inflammatory cytokine release from a variety of different cell types. In summary, we have shown CapG is released following immune cell activation and is able to trigger pro-inflammatory cytokine release from other cells. Combined, the studies in this thesis reveal extracellular CapG as a novel pro-inflammatory mediator. The regulation of CapG at the gene level also points to a role in ongoing inflammatory diseases. This thesis sets the foundation for further analysis of the role of CapG in inflammatory diseases through the use of mice with knockout of the CapG gene or with CapG neutralising antibodies. Such studies will identify if CapG is indeed a novel therapeutic target to alleviate the burden of chronic inflammatory diseases.

Subjects/Keywords: inflammation; CapG; mast cells; macrophage; neuroinflammation

10 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Heng, P. (2017). Characterisation of macrophage capping protein as a novel inflammatory mediator. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/191467

Chicago Manual of Style (16^th Edition):

Heng, Patrick. “Characterisation of macrophage capping protein as a novel inflammatory mediator.” 2017. Doctoral Dissertation, University of Melbourne. Accessed January 21, 2021. http://hdl.handle.net/11343/191467.

MLA Handbook (7^th Edition):

Heng, Patrick. “Characterisation of macrophage capping protein as a novel inflammatory mediator.” 2017. Web. 21 Jan 2021.

Vancouver:

Heng P. Characterisation of macrophage capping protein as a novel inflammatory mediator. [Internet] [Doctoral dissertation]. University of Melbourne; 2017. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/11343/191467.

Council of Science Editors:

Heng P. Characterisation of macrophage capping protein as a novel inflammatory mediator. [Doctoral Dissertation]. University of Melbourne; 2017. Available from: http://hdl.handle.net/11343/191467

4. Silva, Carolina Amorim Vieira e. Aplicação do protocolo FARC de tratamento de DTM com placa oclusal e controle eletromiográfico.

Degree: Mestrado, Odontologia Restauradora, 2008, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/58/58133/tde-27032008-170926/ ;

► A eletromiografia de superfície (EMG) pode ser considerada atualmente um instrumento muito útil, que permite a avaliação quantitativa da musculatura de pacientes com desordem temporomandibular… (more)

▼ A eletromiografia de superfície (EMG) pode ser considerada atualmente um instrumento muito útil, que permite a avaliação quantitativa da musculatura de pacientes com desordem temporomandibular (DTM). O propósito do presente estudo foi aplicar e analisar os efeitos do protocolo FARC de tratamento de DTM com placa oclusal e controle eletromiográfico, comparando os dados da avaliação, de 15 pacientes com DTM, classificados segundo o RDC / TMD, antes e após o tratamento; os resultados da EMG obtidos antes, durante e após o uso da placa por 45 dias, pelo grupo com DTM; e comparando os resultados da EMG de uma população com DTM antes e após o tratamento com placa, com um grupo controle. O exame eletromiográfico dos músculos masseter e temporal anterior foi realizado na primeira sessão de avaliação (Etapa 1), após 1 semana (Etapa 2) e após 5 semanas (Etapa 3) de tratamento, servindo para verificar a estabilidade da placa e a evolução da atividade muscular. As ondas da EMG foram analisadas, por meio do software, e os seguintes índices de EMG foram computados: coeficiente de porcentagem de sobreposição (POC) dos músculos masseter e temporal; coeficiente de torque (TORS); índice de assimetria (ASIM), índice de atividade (ATTIV) e o total da atividade elétrica (IMP). Para os dados expressos em nível intervalar de mensuração, foi empregada estatística não-paramétrica, sendo empregado o teste de Wilcoxon para dados pareados nas análises intra-grupo (entre as etapas). Os dados em nível de razão, foram analisados por meio de estatística paramétrica, sendo empregados para as análises intra-grupo o teste t para dados pareados, para as análises entre grupos o teste t para amostras independentes. O nível de significância estabelecido foi de 5%. Após o tratamento, foi encontrada diferença estatística na capacidade de abertura da boca, assim como na remissão da dor a palpação de grande parte da musculatura avaliada e na ATM. Foi obtida diferença significante no valor de POC do masseter e de IMP, imediatamente após o primeiro ajuste da placa. Quando comparada a etapa 1, sem a placa, com a etapa 2, com a placa ajustada, foi obtida diferença significante nos valores de POC do masseter, de ASIM e de IMP. Houve diferença significante entre as etapas 1, sem placa, e a etapa 3, com placa, nos valores de POC dos músculos masseter e temporal, de ASIM, ATTIV e IMP. Durante todo o tratamento não houve diferença significativa nos índices de EMG dos exames realizados sem a placa. Houve diferença estatística entre os grupos DTM e controle no início e ao final do tratamento, sendo observada diferença significante nos valores de EMG para POC de ambos os músculos e ATTIV. A placa oclusal, embora não tenha mostrado mudanças permanentes, mostrou ser efetiva para promover equilíbrio das atividades da EMG durante seu uso, e eficiente no alívio dos sintomas. Os parâmetros de pesquisa com EMG permitiram seu uso no âmbito cientifico na identificação do desequilíbrio neuromuscular, desta forma este instrumento de avaliação permitiu analisar e avaliar de forma… Advisors/Committee Members: Silva, Marco Antonio Moreira Rodrigues da.

Subjects/Keywords: Electromyography; Eletromiografia; Masseter muscle; Masticatory muscles; Músculo masseter; Músculo temporal; Músculos mastigatórios; Occlusal splints; Placas Oclusais; Síndrome da Disfunção da Articulação Temporomandibular; Temporomandibular Joint Dysfunction Syndrome; Temporomandibular muscle; Terapia; Therapy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Silva, C. A. V. e. (2008). Aplicação do protocolo FARC de tratamento de DTM com placa oclusal e controle eletromiográfico. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/58/58133/tde-27032008-170926/ ;

Chicago Manual of Style (16^th Edition):

Silva, Carolina Amorim Vieira e. “Aplicação do protocolo FARC de tratamento de DTM com placa oclusal e controle eletromiográfico.” 2008. Masters Thesis, University of São Paulo. Accessed January 21, 2021. http://www.teses.usp.br/teses/disponiveis/58/58133/tde-27032008-170926/ ;.

MLA Handbook (7^th Edition):

Silva, Carolina Amorim Vieira e. “Aplicação do protocolo FARC de tratamento de DTM com placa oclusal e controle eletromiográfico.” 2008. Web. 21 Jan 2021.

Vancouver:

Silva CAVe. Aplicação do protocolo FARC de tratamento de DTM com placa oclusal e controle eletromiográfico. [Internet] [Masters thesis]. University of São Paulo; 2008. [cited 2021 Jan 21]. Available from: http://www.teses.usp.br/teses/disponiveis/58/58133/tde-27032008-170926/ ;.

Council of Science Editors:

Silva CAVe. Aplicação do protocolo FARC de tratamento de DTM com placa oclusal e controle eletromiográfico. [Masters Thesis]. University of São Paulo; 2008. Available from: http://www.teses.usp.br/teses/disponiveis/58/58133/tde-27032008-170926/ ;

5. Crosio, Daniel Mazzetto. Eletromiografia dos músculos temporais e masseteres em pacientes com disfunção temporomandibular tratados com placa interoclusal.

Degree: Mestrado, Odontologia Restauradora, 2010, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/58/58133/tde-19102010-083418/ ;

►

Os objetivos do presente estudo foram analisar os efeitos do tratamento de pacientes com Desordem temporomandibular (DTM) articular crônica com a placa interoclusal estabilizadora modelo… (more)

▼

Os objetivos do presente estudo foram analisar os efeitos do tratamento de pacientes com Desordem temporomandibular (DTM) articular crônica com a placa interoclusal estabilizadora modelo Michigan por meio dos índices eletromiográficos POC dos temporais, POC dos masseteres, TORS, ASSIM, Ativação, Ativação absoluta, TORQUE, Impacto, em máximo apertamento dental voluntário (MCV) em máxima intercuspidação habitual (MIH) e máximo apertamento voluntário com algodão entre os dentes (MAA). Foram também analisados os sinais e sintomas de DTM. Participaram do estudo 20 sujeitos, jovens e adultos, sendo 10 com DTM articular crônica, que receberão tratamento com placa oclusal modelo Michigan (Grupo DTM) e 10 sujeitos sem sinais e sintomas de DTM (Grupo Controle). Os sujeitos passarão por exame clínico e responderão ao Protocolo para Determinação dos Sinais e Sintomas de DTM para Centros Multiprofissionais (Felício et al., 2006). Os registros e cálculos dos índices eletromiográficos serão realizados com o Eletromiógrafo Freely de oito canais (De Götzen srl; Legano, Milano, Italy). Foram comparados os dados do grupo DTM na fase de diagnóstico (FD) e na fase final (FF) de tratamento, bem como os dados deste grupo com os do grupo controle. Para os dados expressos em nível intervalar de mensuração, como os dos exames clínicos, foi empregada estatística não-paramétrica. Os dados em nível de razão, isto é os dados eletromiográficos, foram analisados por meio de estatística paramétrica. O nível de significância estabelecido foi de 5%.

The objectives of this study were to analyze the effects of treatment of patients with temporomandibular disorder (TMD) joint with chronic plaque-stabilizing model interocclusal Michigan through electromyographic indices of temporal POC, the POC masseter, TORS, SO, Activation, Activation absolute TORQUE, Impact, for maximum voluntary tooth clenching (MCV) in maximum intercuspal usual (MHI) and maximum voluntary clenching with cotton between teeth (MAA). We also analyzed the signs and symptoms of TMD. The study included 20 subjects, young people and adults, and 10 with chronic articular TMD, which would be treated with occlusal splints Michigan model (DTM Group) and 10 subjects without signs and symptoms of TMD (control group). The subjects will undergo clinical examination and respond to the Protocol for the Determination of the signs and symptoms of TMD for multi Centers (Felicio et al., 2006). Records and calculations of indices electromyographic out with the electromyograph Freely eight channels (De Götzen srl; Legano, Milano, Italy). We compared the data from the DTM group stage of diagnosis (FD) and the final stage (FF) treatment, as well as data from this group with the control group. For data expressed as interval level of measurement, such as clinical examination, was used non-parametric statistics. Data on level of reason, ie electromyographic data were analyzed using parametric statistics. The significance level was set at 5%.

Advisors/Committee Members: Silva, Marco Antonio Moreira Rodrigues da.

Subjects/Keywords: electromyography; eletromiografia; masseter muscle; músculo masséter; músculo temporal; occlusal splints; placas oclusais; temporal muscle; temporomandibular joint disorders; transtornos da articulação temporomandibular

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Crosio, D. M. (2010). Eletromiografia dos músculos temporais e masseteres em pacientes com disfunção temporomandibular tratados com placa interoclusal. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/58/58133/tde-19102010-083418/ ;

Chicago Manual of Style (16^th Edition):

Crosio, Daniel Mazzetto. “Eletromiografia dos músculos temporais e masseteres em pacientes com disfunção temporomandibular tratados com placa interoclusal.” 2010. Masters Thesis, University of São Paulo. Accessed January 21, 2021. http://www.teses.usp.br/teses/disponiveis/58/58133/tde-19102010-083418/ ;.

MLA Handbook (7^th Edition):

Crosio, Daniel Mazzetto. “Eletromiografia dos músculos temporais e masseteres em pacientes com disfunção temporomandibular tratados com placa interoclusal.” 2010. Web. 21 Jan 2021.

Vancouver:

Crosio DM. Eletromiografia dos músculos temporais e masseteres em pacientes com disfunção temporomandibular tratados com placa interoclusal. [Internet] [Masters thesis]. University of São Paulo; 2010. [cited 2021 Jan 21]. Available from: http://www.teses.usp.br/teses/disponiveis/58/58133/tde-19102010-083418/ ;.

Council of Science Editors:

Crosio DM. Eletromiografia dos músculos temporais e masseteres em pacientes com disfunção temporomandibular tratados com placa interoclusal. [Masters Thesis]. University of São Paulo; 2010. Available from: http://www.teses.usp.br/teses/disponiveis/58/58133/tde-19102010-083418/ ;

University of Dundee

6. Atassi, Mounir. Mechanical monitoring of inhibitory jaw reflexes in health and simulated dysfunction.

Degree: PhD, 2014, University of Dundee

URL: https://discovery.dundee.ac.uk/en/studentTheses/abca297e-8951-447b-8c9e-0bb529d211a9 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.642901

► Objectives: Previous studies in the Oral Neurophysiology Laboratories in Dundee have defined the electromyographic properties of the inhibitory jaw reflex that can be evoked in… (more)

▼ Objectives: Previous studies in the Oral Neurophysiology Laboratories in Dundee have defined the electromyographic properties of the inhibitory jaw reflex that can be evoked in human subjects by electrical stimulation of the lip. This reflex, in contrast with the more widely studied biphasic inhibitory reflexes evoked by stimulation of intra-oral nerves, consists of just a single phase of inhibition and usually requires the application of stimuli which excite nociceptive nerves. The aims of the present studies were to define the mechanical manifestations of this reflex in the form of changes in biting forces, and to investigate whether the mechanical manifestation of the inhibitory jaw reflex evoked by stimulation of the human upper lip, can be modulated by experimentally-controlled conditions that mimic symptoms of a myogenous temporomandibular disorder. Methods: Three series of experiments were performed on 49 volunteer subjects in total. The experiments involved recording bite forces between the anterior teeth and electromyograms (EMGs) from the masseter muscles. Transcutaneous electrical stimuli were applied to the hairy skin of upper lip while the subjects maintained a biting force of around 50N with the aid of visual feedback. In the first series of experiments, a range of electrical stimuli below and above the nociceptive threshold was delivered. In the second set of experiments, double stimuli with a range of different inter-stimulus intervals were applied. Finally in a third series of experiments, electrical stimulation was repeated before, immediately after, and 5 and 10 minutes following a 3-minute accelerated chewing task. This task consisted of chewing 1.5g of a tough chewing gum at 1.5 times the subject’s natural chewing rate and in 18 cases, muscle fatigue and/or pain were reported by the subjects. Results: Following stimulation at intensities that were described as sharp or painful, all the subjects showed both a suppression of the masseter EMG and a reduction of biting force. When analysing the maximum responses in each subject, the mean reduction in the EMG inhibition was to 15.78 ± 14.4% and 10.39 ± 7.92% of the baseline (for the ipsi- and contra-lateral EMGs respectively), whereas the biting force was reduced only to 83.98 ± 11.04% of baseline (+ S.D.). The latencies of onset of these responses were: 38.17 ± 3.58ms, 38.97 ± 4.49ms and 51.83 ± 6.23ms respectively. The response observed in the force record was weaker than in that observed in either EMG (Paired t tests, P < 0.005 in both cases). When applying double stimuli, it was found that the prolongation of the EMG inhibitory jaw reflex (to 144.70 ± 46.93% of the control level) evoked by double stimulation of the upper lip (with a 10 ms inter-stimulus interval) resulted in a greater increase in the depth of the accompanied relaxation (to 223.63 ± 70.88% of that seen in the control responses) compared to a relatively smaller increase in the duration of the relaxation (to 128.32 ± 27.23% of that seen in the control responses). Following the…

Subjects/Keywords: 617.6; Jaw reflex; TMD; Pain; Bite force; Temporomandibular Disorders; Masseter muscle; Mastication

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Atassi, M. (2014). Mechanical monitoring of inhibitory jaw reflexes in health and simulated dysfunction. (Doctoral Dissertation). University of Dundee. Retrieved from https://discovery.dundee.ac.uk/en/studentTheses/abca297e-8951-447b-8c9e-0bb529d211a9 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.642901

Chicago Manual of Style (16^th Edition):

Atassi, Mounir. “Mechanical monitoring of inhibitory jaw reflexes in health and simulated dysfunction.” 2014. Doctoral Dissertation, University of Dundee. Accessed January 21, 2021. https://discovery.dundee.ac.uk/en/studentTheses/abca297e-8951-447b-8c9e-0bb529d211a9 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.642901.

MLA Handbook (7^th Edition):

Atassi, Mounir. “Mechanical monitoring of inhibitory jaw reflexes in health and simulated dysfunction.” 2014. Web. 21 Jan 2021.

Vancouver:

Atassi M. Mechanical monitoring of inhibitory jaw reflexes in health and simulated dysfunction. [Internet] [Doctoral dissertation]. University of Dundee; 2014. [cited 2021 Jan 21]. Available from: https://discovery.dundee.ac.uk/en/studentTheses/abca297e-8951-447b-8c9e-0bb529d211a9 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.642901.

Council of Science Editors:

Atassi M. Mechanical monitoring of inhibitory jaw reflexes in health and simulated dysfunction. [Doctoral Dissertation]. University of Dundee; 2014. Available from: https://discovery.dundee.ac.uk/en/studentTheses/abca297e-8951-447b-8c9e-0bb529d211a9 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.642901

University of Toronto

7. Samaan, M. Constantine. Muscle-macrophage & Macrophage-macrophage Interactions in Diabetogenic Environment.

Degree: 2011, University of Toronto

URL: http://hdl.handle.net/1807/27543

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Diabetes and obesity are associated with inflammation and activation of the immune system with infiltration of adipose tissue by macrophages. This is mainly studied in… (more)

Subjects/Keywords: Obesity; Inflammation; Diabetes; Macrophage; Muscle; 0379

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Samaan, M. C. (2011). Muscle-macrophage & Macrophage-macrophage Interactions in Diabetogenic Environment. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/27543

Chicago Manual of Style (16^th Edition):

Samaan, M Constantine. “Muscle-macrophage & Macrophage-macrophage Interactions in Diabetogenic Environment.” 2011. Masters Thesis, University of Toronto. Accessed January 21, 2021. http://hdl.handle.net/1807/27543.

MLA Handbook (7^th Edition):

Samaan, M Constantine. “Muscle-macrophage & Macrophage-macrophage Interactions in Diabetogenic Environment.” 2011. Web. 21 Jan 2021.

Vancouver:

Samaan MC. Muscle-macrophage & Macrophage-macrophage Interactions in Diabetogenic Environment. [Internet] [Masters thesis]. University of Toronto; 2011. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/1807/27543.

Council of Science Editors:

Samaan MC. Muscle-macrophage & Macrophage-macrophage Interactions in Diabetogenic Environment. [Masters Thesis]. University of Toronto; 2011. Available from: http://hdl.handle.net/1807/27543

8. Sawai, Akiho; Ito, Yasuhiko; Mizuno, Masashi; Suzuki, Yasuhiro; Toda, Susumu; Ito, Isao; Hattori, Ryohei; Matsukawa, Yoshihisa; Gotoh, Momokazu; Takei, Yoshifumi; Yuzawa, Yukio. Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients.

Degree: 2018, Nagoya University / 名古屋大学

URL: http://hdl.handle.net/2237/14924

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Background: High baseline peritoneal solute transport rate is reportedly associated with reduced patient and technique survival in continuous peritoneal dialysis (PD) patients. However, the determinants… (more)

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Background: High baseline peritoneal solute transport rate is reportedly associated with reduced patient and technique survival in continuous peritoneal dialysis (PD) patients. However, the determinants of baseline peritoneal solute transport rate remain uncertain. The aim of this study was to investigate the relationship between peritoneal local inflammation, angiogenesis and systemic inflammation and baseline peritoneal permeability. Methods: Peritoneal biopsy specimens from 42 pre-dialysis uraemic patients and 11 control individuals were investigated. Immunohistochemistry for CD68-positive macrophages, chymase- and tryptase-positive mast cells, interleukin-6 (IL-6)-positive cells, CD3-positive T cells, CD20-positive B cells, neutrophils and CD31- and pathologische anatomie Leiden-endothelium (PAL-E)- positive blood vessels in the peritoneum was performed. Baseline dialysate-to-plasma ratio for creatinine (D/P Cr) was determined within 6 months of PD induction. Clinical and laboratory parameters were measured at the time of peritoneal biopsy. Factors associated with peritoneal permeability were assessed by multiple linear regression analysis. Results: Pre-dialysis uraemic peritoneum showed infiltration by CD68-positive macrophages, and mast cells, as compared with controls. Baseline D/P Cr was correlated with density of CD68-positive macrophages (P < 0.001), IL-6-positive cells (P < 0.001), CD31-positive (P < 0.05) and PAL-E-positive blood vessels (P < 0.05) and serum albumin (P < 0.05). However, baseline peritoneal permeability was not correlated with infiltration by mast cells, B cells, T cells, neutrophils, serum C-reactive protein or other clinical factors. On multiple linear regression analysis, the number of CD68-positive macrophages in peritoneum was an independent predictor for baseline peritoneal permeability (P = 0.009). Conclusions: Peritoneal macrophage infiltration is predominant in uraemic patients and is an important factor in predicting baseline peritoneal permeability.

名古屋大学博士学位論文学位の種類 : 博士(医学)(課程) 学位授与年月日:平成23年3月25日澤井晶穂氏の博士論文として提出された

[First published online] 2010-11-22

Subjects/Keywords: blood vessel; D/P Cr; inflammation; macrophage; mast cell

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APA (6^th Edition):

Sawai, Akiho; Ito, Yasuhiko; Mizuno, Masashi; Suzuki, Yasuhiro; Toda, Susumu; Ito, Isao; Hattori, Ryohei; Matsukawa, Yoshihisa; Gotoh, Momokazu; Takei, Yoshifumi; Yuzawa, Y. (2018). Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients. (Thesis). Nagoya University / 名古屋大学. Retrieved from http://hdl.handle.net/2237/14924

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sawai, Akiho; Ito, Yasuhiko; Mizuno, Masashi; Suzuki, Yasuhiro; Toda, Susumu; Ito, Isao; Hattori, Ryohei; Matsukawa, Yoshihisa; Gotoh, Momokazu; Takei, Yoshifumi; Yuzawa, Yukio. “Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients.” 2018. Thesis, Nagoya University / 名古屋大学. Accessed January 21, 2021. http://hdl.handle.net/2237/14924.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sawai, Akiho; Ito, Yasuhiko; Mizuno, Masashi; Suzuki, Yasuhiro; Toda, Susumu; Ito, Isao; Hattori, Ryohei; Matsukawa, Yoshihisa; Gotoh, Momokazu; Takei, Yoshifumi; Yuzawa, Yukio. “Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients.” 2018. Web. 21 Jan 2021.

Vancouver:

Sawai, Akiho; Ito, Yasuhiko; Mizuno, Masashi; Suzuki, Yasuhiro; Toda, Susumu; Ito, Isao; Hattori, Ryohei; Matsukawa, Yoshihisa; Gotoh, Momokazu; Takei, Yoshifumi; Yuzawa Y. Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients. [Internet] [Thesis]. Nagoya University / 名古屋大学; 2018. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/2237/14924.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sawai, Akiho; Ito, Yasuhiko; Mizuno, Masashi; Suzuki, Yasuhiro; Toda, Susumu; Ito, Isao; Hattori, Ryohei; Matsukawa, Yoshihisa; Gotoh, Momokazu; Takei, Yoshifumi; Yuzawa Y. Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients. [Thesis]. Nagoya University / 名古屋大学; 2018. Available from: http://hdl.handle.net/2237/14924

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Duquesne University

9. Saleem, Muzamil. Nanomedicine-driven neuropathic pain relief in rat model is associated with macrophage polarity and mast cell activation.

Degree: PhD, Biological Sciences, 2019, Duquesne University

URL: https://dsc.duq.edu/etd/1854

► We explored the immune neuropathology underlying multi-day relief from neuropathic pain in a rat model initiated at the sciatic nerve by using a nanoemulsion-based… (more)

▼ We explored the immune neuropathology underlying multi-day relief from neuropathic pain in a rat model initiated at the sciatic nerve by using a nanoemulsion-based nanomedicine as a biological probe. The nanomedicine is theranostic: both therapeutic (containing celecoxib drug) and diagnostic (containing near-infrared fluorescent (NIRF) dye) and is small enough to be phagocytosed by circulating monocytes. A model of neuropathic pain is initiated by tying four 1mm spaced knots around the sciatic nerve with chromic gut suture, which results in neuroinflammation, and a resultant pain-like behavior manifests. We show that pain-like behavior reaches a plateau of maximum hypersensitivity 8 days post-surgery, and is the rationale for intravenous delivery at this time-point. Pain relief is evident within 24 hours, lasting approximately 6 days. The ipsilateral sciatic nerve and associated L4 and L5 dorsal root ganglia (DRG) tissue of both nanomedicine and control (nanoemulsion without drug) treated animals was investigated by immunofluorescence and confocal microscopy at the peak of pain relief (day 12 post-surgery), and when pain-like hypersensitivity returns (day 18 post-surgery). At day 12, a significant reduction of infiltrating macrophages, mast cells and mast cell degranulation was observed at the sciatic nerve following treatment. In the DRG, there was no effect of treatment at both day 12 and day 18 on the numbers of macrophages and mast cells. Conversely, at the DRG, there is a significant increase in macrophage infiltration and mast cell degranulation at day 18. The treatment effect on immune pathology in the sciatic nerve was investigated further by assessing the expression of macrophage cyclooxygenase-2 (COX-2)—the drug target – and extracellular prostaglandin E2 (PGE2), as well as the proportion of M1 (pro-inflammatory) and M2 (anti-inflammatory) macrophages. At day 12, there is a significant reduction of COX-2 positive macrophages, extracellular PGE2, and a striking reversal of macrophage polarity. At day 18, these measures revert to levels observed in control-treated animals. Here we present a new paradigm of immune neuropathology research, by employing a nanomedicine to target a mechanism of neuropathic pain—resulting in long-lasting pain relief – whilst revealing novel immune pathology at the injured nerve and associated DRG. The pathology of pain relief that these studies reveal, highlights a crucial concept: that a single nanomedicine dose targeted to general peripheral neuroinflammation, may not be sufficient—that a treatment plan could be modified to firstly include additional treatment points, and secondly target the associated DRG in order to dampen the inflammation and pain signaling emanating there. Advisors/Committee Members: Dr. John A. Pollock, Dr. Jelena M. Janjic, Dr. Benedict J. Kolber, Dr. Nicholas F. Fitz.

Subjects/Keywords: Inflammation; Nanomedicine; Neuropathic pain; Chronic pain; Macrophage; Mast cell; Molecular and Cellular Neuroscience

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Saleem, M. (2019). Nanomedicine-driven neuropathic pain relief in rat model is associated with macrophage polarity and mast cell activation. (Doctoral Dissertation). Duquesne University. Retrieved from https://dsc.duq.edu/etd/1854

Chicago Manual of Style (16^th Edition):

Saleem, Muzamil. “Nanomedicine-driven neuropathic pain relief in rat model is associated with macrophage polarity and mast cell activation.” 2019. Doctoral Dissertation, Duquesne University. Accessed January 21, 2021. https://dsc.duq.edu/etd/1854.

MLA Handbook (7^th Edition):

Saleem, Muzamil. “Nanomedicine-driven neuropathic pain relief in rat model is associated with macrophage polarity and mast cell activation.” 2019. Web. 21 Jan 2021.

Vancouver:

Saleem M. Nanomedicine-driven neuropathic pain relief in rat model is associated with macrophage polarity and mast cell activation. [Internet] [Doctoral dissertation]. Duquesne University; 2019. [cited 2021 Jan 21]. Available from: https://dsc.duq.edu/etd/1854.

Council of Science Editors:

Saleem M. Nanomedicine-driven neuropathic pain relief in rat model is associated with macrophage polarity and mast cell activation. [Doctoral Dissertation]. Duquesne University; 2019. Available from: https://dsc.duq.edu/etd/1854

Malmö University

10. Dawson, Andreas. Experimental tooth clenching : a model for studying mechanisms of muscle pain .

Degree: Malmö University. Faculty of Odontology, 2013, Malmö University

URL: http://hdl.handle.net/2043/15410

► The overall goal of this thesis was to broaden knowledge of pain mechanisms in myofascial temporomandibular disorders (M-TMD). The specific aims were to: • Develop… (more)

▼ The overall goal of this thesis was to broaden knowledge of pain mechanisms in myofascial temporomandibular disorders (M-TMD). The specific aims were to: • Develop a quality assessment tool for experimental bruxism studies (study I). • Investigate proprioceptive allodynia after experimental tooth clenching exercises (study II). • Evaluate the release of serotonin (5-HT), glutamate, pyruvate, and lactate in healthy subjects (study III) and in patients with M-TMD (study IV), after experimental tooth clenching exercises. In (I), tool development comprised 5 steps: (i) preliminary decisions, (ii) item generation, (iii) face-validity assessment, (iv) reliability and discriminative validity testing, and (v) instrument refinement. After preliminary decisions and a literature review, a list of 52 items to be considered for inclusion in the tool was generated. Eleven experts were invited to participate on the Delphi panel, of which 10 agreed. After four Delphi rounds, 8 items remained and were included in the Quality Assessment Tool for Experimental Bruxism Studies (Qu-ATEBS). Inter-observer reliability was acceptable (k = 0.77), and discriminative validity high (phi coefficient 0.79; P < 0.01). During refinement, 1 item was removed; the final tool comprised 7 items. In (II), 16 healthy females participated in three 60-min sessions, each with 24- and 48-h follow-ups. Participants were randomly assigned to a repetitive experimental tooth clenching task with 10 a clenching level of 10%, 20%, or 40% of maximal voluntary clenching force (MVCF). Pain intensity, fatigue, perceived intensity of vibration (PIV), perceived discomfort (PD), and pressure pain threshold (PPT) were measured throughout. A significant increase in pain intensity and fatigue but not in PD was observed over time. A significant increase in PIV was only observed at 40 min, and PPT decreased significantly over time at 50 and 60 min compared to baseline. In (III), 30 healthy subjects (16 females, and 14 males) participated in two sessions at a minimum interval of 1 wk. Microdialysis was done to collect 5-HT, glutamate, pyruvate, and lactate and to measure masseter muscle blood flow. Two hours after the start of microdialysis, participants were randomized to a 20- min repetitive experimental tooth clenching task (50% of MVCF) or a control session (no clenching). Pain intensity was measured throughout the experiment. Substance levels and blood flow were unaltered at all time points between sessions, and between genders in each session. Pain intensity was significantly higher after clenching in the clenching session compared to the same time point in the control session. In (IV), 15 patients with M-TMD and 15 healthy controls participated in one session and the methodology described above was used. M-TMD patients had significantly higher levels of 5-HT and significantly lower blood flows than healthy controls. No significant differences for any substance at any time point were observed between groups. Time and group…

Subjects/Keywords: tooth clenching; muscle pain; bruxism; Delphi technique; pain measurement; masticatory muscles; experimental pain; proprioceptive allodynia; temporomandibular disorders; serotonin; glutamate; masseter muscle; microdialysis

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APA (6^th Edition):

Dawson, A. (2013). Experimental tooth clenching : a model for studying mechanisms of muscle pain . (Thesis). Malmö University. Retrieved from http://hdl.handle.net/2043/15410

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dawson, Andreas. “Experimental tooth clenching : a model for studying mechanisms of muscle pain .” 2013. Thesis, Malmö University. Accessed January 21, 2021. http://hdl.handle.net/2043/15410.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dawson, Andreas. “Experimental tooth clenching : a model for studying mechanisms of muscle pain .” 2013. Web. 21 Jan 2021.

Vancouver:

Dawson A. Experimental tooth clenching : a model for studying mechanisms of muscle pain . [Internet] [Thesis]. Malmö University; 2013. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/2043/15410.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dawson A. Experimental tooth clenching : a model for studying mechanisms of muscle pain . [Thesis]. Malmö University; 2013. Available from: http://hdl.handle.net/2043/15410

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

11. Ebrahimi, Eric. Musculo-aponeurotic Architecture of the Human Masseter Muscle: A Three-dimensional Cadaveric Study.

Degree: 2015, University of Toronto

URL: http://hdl.handle.net/1807/70284

►

Masseter muscle (MM) has been found to undergo morphological changes in temporomandibular disorders (TMDs). These changes are poorly understood even though muscle architecture is an… (more)

Subjects/Keywords: Architecture; Masseter; Modeling; Temporomandibular Disorders; 0567

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ebrahimi, E. (2015). Musculo-aponeurotic Architecture of the Human Masseter Muscle: A Three-dimensional Cadaveric Study. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/70284

Chicago Manual of Style (16^th Edition):

Ebrahimi, Eric. “Musculo-aponeurotic Architecture of the Human Masseter Muscle: A Three-dimensional Cadaveric Study.” 2015. Masters Thesis, University of Toronto. Accessed January 21, 2021. http://hdl.handle.net/1807/70284.

MLA Handbook (7^th Edition):

Ebrahimi, Eric. “Musculo-aponeurotic Architecture of the Human Masseter Muscle: A Three-dimensional Cadaveric Study.” 2015. Web. 21 Jan 2021.

Vancouver:

Ebrahimi E. Musculo-aponeurotic Architecture of the Human Masseter Muscle: A Three-dimensional Cadaveric Study. [Internet] [Masters thesis]. University of Toronto; 2015. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/1807/70284.

Council of Science Editors:

Ebrahimi E. Musculo-aponeurotic Architecture of the Human Masseter Muscle: A Three-dimensional Cadaveric Study. [Masters Thesis]. University of Toronto; 2015. Available from: http://hdl.handle.net/1807/70284

Brigham Young University

12. Sorensen, Jacob R. Repair and Adaptation of Aged Skeletal Muscle to Nonpathological Muscle Damage: The Influence of Macrophage Polarization.

Degree: PhD, 2018, Brigham Young University

URL: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=8691&context=etd

► The age-related loss of skeletal muscle mass and function is accompanied by a decline in regenerative capacity. The processes that facilitate healthy muscle repair are… (more)

Subjects/Keywords: satellite cells; macrophage; inflammation; exercise-induced muscle damage; extracellular matrix; Life Sciences

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APA (6^th Edition):

Sorensen, J. R. (2018). Repair and Adaptation of Aged Skeletal Muscle to Nonpathological Muscle Damage: The Influence of Macrophage Polarization. (Doctoral Dissertation). Brigham Young University. Retrieved from https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=8691&context=etd

Chicago Manual of Style (16^th Edition):

Sorensen, Jacob R. “Repair and Adaptation of Aged Skeletal Muscle to Nonpathological Muscle Damage: The Influence of Macrophage Polarization.” 2018. Doctoral Dissertation, Brigham Young University. Accessed January 21, 2021. https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=8691&context=etd.

MLA Handbook (7^th Edition):

Sorensen, Jacob R. “Repair and Adaptation of Aged Skeletal Muscle to Nonpathological Muscle Damage: The Influence of Macrophage Polarization.” 2018. Web. 21 Jan 2021.

Vancouver:

Sorensen JR. Repair and Adaptation of Aged Skeletal Muscle to Nonpathological Muscle Damage: The Influence of Macrophage Polarization. [Internet] [Doctoral dissertation]. Brigham Young University; 2018. [cited 2021 Jan 21]. Available from: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=8691&context=etd.

Council of Science Editors:

Sorensen JR. Repair and Adaptation of Aged Skeletal Muscle to Nonpathological Muscle Damage: The Influence of Macrophage Polarization. [Doctoral Dissertation]. Brigham Young University; 2018. Available from: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=8691&context=etd

University of Adelaide

13. Scutter, Sheila Doreen. H-reflex in human masseter / by Sheila Doreen Scutter.

Degree: 1999, University of Adelaide

URL: http://hdl.handle.net/2440/19483

► H-relexes are used to determine the reflex connections of muscle spindle afferents, the exitability of the motorneuron pool and the integrity of the reflex pathways.… (more)

Subjects/Keywords: Masseter muscle Physiology.

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APA (6^th Edition):

Scutter, S. D. (1999). H-reflex in human masseter / by Sheila Doreen Scutter. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/19483

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Scutter, Sheila Doreen. “H-reflex in human masseter / by Sheila Doreen Scutter.” 1999. Thesis, University of Adelaide. Accessed January 21, 2021. http://hdl.handle.net/2440/19483.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Scutter, Sheila Doreen. “H-reflex in human masseter / by Sheila Doreen Scutter.” 1999. Web. 21 Jan 2021.

Vancouver:

Scutter SD. H-reflex in human masseter / by Sheila Doreen Scutter. [Internet] [Thesis]. University of Adelaide; 1999. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/2440/19483.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Scutter SD. H-reflex in human masseter / by Sheila Doreen Scutter. [Thesis]. University of Adelaide; 1999. Available from: http://hdl.handle.net/2440/19483

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Cornell University

14. Sinha, Siddhartha. Role Of Substrate Stiffness In Driving Atherogenic Behavior In Macrophages.

Degree: M.S., Physiology, Physiology, 2014, Cornell University

URL: http://hdl.handle.net/1813/37128

► Atherosclerosis is a decades-long process whose patients often remain asymptomatic until after a heart attack or stroke. Novel therapeutic approaches focus on tuning the body's… (more)

Subjects/Keywords: Atherosclerosis; Inflammation; Macrophage

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APA (6^th Edition):

Sinha, S. (2014). Role Of Substrate Stiffness In Driving Atherogenic Behavior In Macrophages. (Masters Thesis). Cornell University. Retrieved from http://hdl.handle.net/1813/37128

Chicago Manual of Style (16^th Edition):

Sinha, Siddhartha. “Role Of Substrate Stiffness In Driving Atherogenic Behavior In Macrophages.” 2014. Masters Thesis, Cornell University. Accessed January 21, 2021. http://hdl.handle.net/1813/37128.

MLA Handbook (7^th Edition):

Sinha, Siddhartha. “Role Of Substrate Stiffness In Driving Atherogenic Behavior In Macrophages.” 2014. Web. 21 Jan 2021.

Vancouver:

Sinha S. Role Of Substrate Stiffness In Driving Atherogenic Behavior In Macrophages. [Internet] [Masters thesis]. Cornell University; 2014. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/1813/37128.

Council of Science Editors:

Sinha S. Role Of Substrate Stiffness In Driving Atherogenic Behavior In Macrophages. [Masters Thesis]. Cornell University; 2014. Available from: http://hdl.handle.net/1813/37128

Vanderbilt University

15. Stouch, Ashley Nicole. NF-kappa B signaling and inflammasome activation in developing fetal lung macrophages.

Degree: PhD, Cell and Developmental Biology, 2014, Vanderbilt University

URL: http://hdl.handle.net/1803/15353

► Bronchopulmonary dysplasia is a life-threatening lung disease affecting low birth weight preterm infants. While the occurrence of BPD is correlated with chorioamnionitis, the origination and… (more)

Subjects/Keywords: macrophage; inflammasome; inflammation

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APA (6^th Edition):

Stouch, A. N. (2014). NF-kappa B signaling and inflammasome activation in developing fetal lung macrophages. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/15353

Chicago Manual of Style (16^th Edition):

Stouch, Ashley Nicole. “NF-kappa B signaling and inflammasome activation in developing fetal lung macrophages.” 2014. Doctoral Dissertation, Vanderbilt University. Accessed January 21, 2021. http://hdl.handle.net/1803/15353.

MLA Handbook (7^th Edition):

Stouch, Ashley Nicole. “NF-kappa B signaling and inflammasome activation in developing fetal lung macrophages.” 2014. Web. 21 Jan 2021.

Vancouver:

Stouch AN. NF-kappa B signaling and inflammasome activation in developing fetal lung macrophages. [Internet] [Doctoral dissertation]. Vanderbilt University; 2014. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/1803/15353.

Council of Science Editors:

Stouch AN. NF-kappa B signaling and inflammasome activation in developing fetal lung macrophages. [Doctoral Dissertation]. Vanderbilt University; 2014. Available from: http://hdl.handle.net/1803/15353

16. Botelho, André Luís. Coordenação neuromuscular e assimetria de atividade eletromiográfica em sujeitos assintomáticos para disfunção temporomandibular.

Degree: Mestrado, Odontologia Restauradora, 2009, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/58/58133/tde-19022009-171237/ ;

►

O padrão de contração de músculos pares pode ser investigado usando eletromiografia (EMG) de superfície. Isto torna possível saber quando e como um músculo é… (more)

▼

O padrão de contração de músculos pares pode ser investigado usando eletromiografia (EMG) de superfície. Isto torna possível saber quando e como um músculo é ativado e ainda determinar como se estabelece a coordenação de diferentes músculos envolvidos no movimento. Além disso, a influência da condição oclusal sobre a função estomatognática também pode ser avaliada por meio da eletromiografia. Este trabalho teve por objetivo analisar e descrever as características de coordenação e (as)simetria, nos músculos masseter e temporal anterior durante os testes estático e dinâmico em uma população brasileira de sujeitos jovens adultos saudáveis, assintomáticos para disfunção temporomandibular, por meio de um novo instrumento de registro eletromiográfico. Para isso, participaram da pesquisa 100 sujeitos. Todos realizaram o teste estático e 60 sujeitos foram selecionados para realizar o teste dinâmico da mandíbula. Os resultados demonstraram que os sujeitos jovens adultos avaliados apresentaram valores médios dos índices eletromiográficos dentro dos padrões de normalidade já estabelecidos previamente para outras populações. Este padrão de normalidade parece refletir em um bom desempenho funcional do sistema estomatognático, como o encontrado na avaliação miofuncional. Provavelmente os valores sejam válidos para a população brasileira, porém estudos com amostras mais numerosas deverão ser realizados.

The contraction pattern of paired muscles can be investigated using surface electromyography (EMG). This makes it possible to know when and how a muscle is activated as well as determine the coordination of different muscles involved in the movement. Furthermore, the influence of occlusal condition on the stomatognathic function can also be evaluated by electromyography. This study aimed to examine and describe the characteristics of coordination and (a)symmetry in the masseter and temporal muscles during the previous static and dynamic tests in a population of subjects young healthy adults, asymptomatic for temporomandibular dysfunction, using a new electromyographic instrument. For this, 100 subjects participated in the study. All performed the static test and 60 subjects were selected to perform the dynamic test of the jaw. The results showed that the young adults subjects evaluated showed average values of the electromyographic index within the normal range already set previously for other people. This pattern of normality seems to reflect a good performance of the stomatognathic system, as found in myofunctional evaluation. Probably the figures are valid for the Brazilian population, but studies with larger samples should be conducted.

Advisors/Committee Members: Silva, Marco Antonio Moreira Rodrigues da.

Subjects/Keywords: asymptomatic subjects; electromyography; eletromiografia; masseter muscle; músculo masseter; músculo temporal; sujeitos assintomáticos; temporal muscle

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APA (6^th Edition):

Botelho, A. L. (2009). Coordenação neuromuscular e assimetria de atividade eletromiográfica em sujeitos assintomáticos para disfunção temporomandibular. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/58/58133/tde-19022009-171237/ ;

Chicago Manual of Style (16^th Edition):

Botelho, André Luís. “Coordenação neuromuscular e assimetria de atividade eletromiográfica em sujeitos assintomáticos para disfunção temporomandibular.” 2009. Masters Thesis, University of São Paulo. Accessed January 21, 2021. http://www.teses.usp.br/teses/disponiveis/58/58133/tde-19022009-171237/ ;.

MLA Handbook (7^th Edition):

Botelho, André Luís. “Coordenação neuromuscular e assimetria de atividade eletromiográfica em sujeitos assintomáticos para disfunção temporomandibular.” 2009. Web. 21 Jan 2021.

Vancouver:

Botelho AL. Coordenação neuromuscular e assimetria de atividade eletromiográfica em sujeitos assintomáticos para disfunção temporomandibular. [Internet] [Masters thesis]. University of São Paulo; 2009. [cited 2021 Jan 21]. Available from: http://www.teses.usp.br/teses/disponiveis/58/58133/tde-19022009-171237/ ;.

Council of Science Editors:

Botelho AL. Coordenação neuromuscular e assimetria de atividade eletromiográfica em sujeitos assintomáticos para disfunção temporomandibular. [Masters Thesis]. University of São Paulo; 2009. Available from: http://www.teses.usp.br/teses/disponiveis/58/58133/tde-19022009-171237/ ;

17. Sousa, Carla. O efeito da técnica de inibição de Jones nos músculos Masseter e temporal nas disfunções temporomandibulares.

Degree: 2013, Instituto Politécnico do Porto

URL: http://www.rcaap.pt/detail.jsp?id=oai:recipp.ipp.pt:10400.22/2497

►

Introdução: A disfunção temporomandibular (DTM), de causa muscular, caracteriza-se por uma dor músculo-esquelética crónica, com sinais e sintomas específicos como a presença de Trigger Points… (more)

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Introdução: A disfunção temporomandibular (DTM), de causa muscular, caracteriza-se por uma dor músculo-esquelética crónica, com sinais e sintomas específicos como a presença de Trigger Points (TrPs). Objetivo: Avaliar o efeito da Técnica de Inibição de Jones (TIJ) nos músculos masseter e temporal em indivíduos com DTM, e a identificação dos sinais e sintomas, a relação entre a severidade da DTM, a ansiedade e a qualidade de sono. Métodos: Estudo quasi-experimental, constituído por 16 indivíduos no grupo experimental (GE) e 17 grupo controle (GC). O grau de severidade foi avaliado pelo Índice de Helkimo e as alterações do sono pelo questionário de Pittsburgh sobre a qualidade do sono. Apenas o GE foi sujeito a uma TIJ nos TrPs latentes dos músculos masseter e temporal. Os dois grupos foram avaliados pré-intervenção (M0), pós-intervenção (M1) e 3 semanas após (M2), as amplitudes de movimento ativas de abertura, lateralidade direita/esquerda e protusão da boca bem como a dor (EVA) em repouso e na abertura máxima. Resultados: Foi possível observar que quanto maior o grau de DTM, maior a frequência de ansiedade e pior a qualidade do sono. Observou-se um decréscimo de TrPs, no GE, após a aplicação da técnica, principalmente no masseter. Não foi possível verificar diferenças inter-grupos. Contudo, observou-se no GE uma melhoria em todas as amplitudes avaliadas entre o M0 e o M2. Em relação à EVA em repouso e na abertura máxima, o GE demonstrou diminuição da dor no M1 e manteve valores inferiores no M2. Conclusão: Verifica-se uma diminuição dos TrPs, uma melhoria das amplitudes ativas bem como uma diminuição da dor após a aplicação da TIJ no GE. Já ao longo do tempo, o efeito é menos expressivo contudo observam-se valores inferiores comparativamente a M0.

The temporomandibular dysfunction (TMD), by muscle cause, is characterized by a chronic musculoskeletal pain, with specific signs and symptoms such as the presence of Trigger Points (TrPs). Objective: To evaluate the effect of Inhibition Technique of Jones (ITJ) in the masseter and temporal muscles in TMD patients, and the identification of signs and symptoms, the relation between TMD severity, anxiety and sleep quality. Methods: A quasi-experimental study, with 16 subjects in the experimental group (EG) and 17 in the control group (CG). The degree of severity was assessed by Helkimo Index and sleep disorders by Pittsburgh’s Sleep Quality Questionnaire. Only GE has been subject to ICJ on latent TRPs in the masseter and temporal muscles. The two groups were assessed pre-intervention (M0), post-intervention (M1) and 3 weeks after (M2), range of motion active opening, laterality left / right and protrusion of the mouth and pain (VAS) in rest and at maximum aperture. Conclusion: It was observed that the greater the degree of TMD, the higher the frequency of anxiety and poor sleep quality. There was a decrease of TRPs in GE, after application of the technique, especially in masseter. Unable to verify differences between groups. However, there was an improvement in GE in all…

Advisors/Committee Members: Mesquita, Cristina.

Subjects/Keywords: Disfunção temporomandibular; Masseter; Temporal; Técnica de Jones; Temporomandibular disorders; Inhibition technique of Jones

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sousa, C. (2013). O efeito da técnica de inibição de Jones nos músculos Masseter e temporal nas disfunções temporomandibulares. (Thesis). Instituto Politécnico do Porto. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:recipp.ipp.pt:10400.22/2497

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sousa, Carla. “O efeito da técnica de inibição de Jones nos músculos Masseter e temporal nas disfunções temporomandibulares.” 2013. Thesis, Instituto Politécnico do Porto. Accessed January 21, 2021. http://www.rcaap.pt/detail.jsp?id=oai:recipp.ipp.pt:10400.22/2497.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sousa, Carla. “O efeito da técnica de inibição de Jones nos músculos Masseter e temporal nas disfunções temporomandibulares.” 2013. Web. 21 Jan 2021.

Vancouver:

Sousa C. O efeito da técnica de inibição de Jones nos músculos Masseter e temporal nas disfunções temporomandibulares. [Internet] [Thesis]. Instituto Politécnico do Porto; 2013. [cited 2021 Jan 21]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:recipp.ipp.pt:10400.22/2497.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sousa C. O efeito da técnica de inibição de Jones nos músculos Masseter e temporal nas disfunções temporomandibulares. [Thesis]. Instituto Politécnico do Porto; 2013. Available from: http://www.rcaap.pt/detail.jsp?id=oai:recipp.ipp.pt:10400.22/2497

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Houston

18. Zhang, Wanyu. Macrophages in Corneal Epithelial Wound Healing.

Degree: PhD, Physiological Optics and Vision Science, 2014, University of Houston

URL: http://hdl.handle.net/10657/4731

► Purpose: After corneal epithelial injury, the ensuing inflammatory response is necessary for efficient wound healing. While beneficial healing effects are attributed to recruited neutrophils and… (more)

▼ Purpose: After corneal epithelial injury, the ensuing inflammatory response is necessary for efficient wound healing. While beneficial healing effects are attributed to recruited neutrophils and platelets, little is known regarding the relative distribution of macrophage phenotypes within the cornea and whether macrophages contribute to the inflammatory cascade that is so important for corneal wound healing. The objectives of this research were: (1) To characterize macrophages in normal and wounded mouse corneas; (2) To determine if macrophage-derived IL-20 plays a beneficial role in corneal wound healing; (3) To determine if oncomodulin, a potent stimulus for nerve regeneration known to be present in macrophages and neutrophils, plays a beneficial role in corneal wound healing. Methods: In all wounded corneas, a 2mm diameter central epithelial region was mechanically debrided with a gulf-club spud. (1) Fluorescently tagged antibodies raised against mouse macrophage markers (F4/80, CD115, CX3CR1 and CD206) together with known M1 (CD80, CD86) and M2 (CD301) pro- and anti-inflammatory markers, respectively, were used to identify and localize macrophages within corneal wholemounts of wildtype mice before and after injury (24, 48, 72h and 7days). To enumerate different macrophage phenotypes within the cornea, whole mounts were sub-divided into five regions: (a) limbus (L), (b) paralimbus (PL), (c) parawound (PW), (d) wound (W) and (e) wound center (WC). Within each region, a single camera field (40X, 150 x 150 µm) was recorded and cells staining positively for macrophage markers were counted. (2) Injured female wildtype C57BL/6 mouse corneas were topically treated every 4h up to 24h with 10l of neutralizing IL-20 antibody (200g/ml) or control antibody (non-immune isotype matched IgG). To examine the effects of recombinant IL-20 (rIl-20) on epithelial wound healing, wildtype mice, neutrophil-depleted wildtype mice (anti-Ly6G antibody pre-treatment) , and mutant mice known to have reduced neutrophil infiltration (ɣδ T cell deficient mice (TCR-/-) and CD11a deficient mice (CD11a-/-)) received 10µL of rIL-20 dissolved in phosphate buffered saline (200ng/mL) every 4h up to 24h, while appropriate control mice received buffer only. The rate of corneal wound closure, the numbers of dividing basal epithelial cells, infiltrating neutrophils, and platelets, and the density of epithelial nerves were evaluated. Some corneas were prepared for immunofluorescence microscopy to localize IL-20 and its receptor, IL-20R1. (3) Some wildtype mice receiving corneal epithelial abrasions were topically treated with oncomodulin-specific blocking peptide P1 (100ng/5ul) or control peptide P3 (100ng/5ul), respectively. The process was repeated every 6 hours for 24 hours. The rate of corneal wound closure, epithelial nerve density, and number of dividing epithelial cells were evaluated to assess the functional contribution of oncomodulin on epithelial wound healing. Some dissected mouse corneas were immunostained with anti-oncomodulin antibody… Advisors/Committee Members: Burns, Alan R. (advisor), Miller, William L. (committee member), Redfern, Rachel (committee member), Smith, C. Wayne (committee member).

Subjects/Keywords: Macrophage; IL-20; Oncomodulin; Mast cells

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zhang, W. (2014). Macrophages in Corneal Epithelial Wound Healing. (Doctoral Dissertation). University of Houston. Retrieved from http://hdl.handle.net/10657/4731

Chicago Manual of Style (16^th Edition):

Zhang, Wanyu. “Macrophages in Corneal Epithelial Wound Healing.” 2014. Doctoral Dissertation, University of Houston. Accessed January 21, 2021. http://hdl.handle.net/10657/4731.

MLA Handbook (7^th Edition):

Zhang, Wanyu. “Macrophages in Corneal Epithelial Wound Healing.” 2014. Web. 21 Jan 2021.

Vancouver:

Zhang W. Macrophages in Corneal Epithelial Wound Healing. [Internet] [Doctoral dissertation]. University of Houston; 2014. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/10657/4731.

Council of Science Editors:

Zhang W. Macrophages in Corneal Epithelial Wound Healing. [Doctoral Dissertation]. University of Houston; 2014. Available from: http://hdl.handle.net/10657/4731

19. Campolongo, Gabriel Denser. Avaliação eletromiográfica do músculo masseter nos pacientes portadores de fratura de face.

Degree: PhD, Cirurgia e Traumatologia Buco-Maxilo-Faciais, 2012, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/23/23149/tde-11092012-131536/ ;

►

Este estudo analisou por meio de um eletromiógrafo de superfície as atividades dos músculos masseteres, direito e esquerdo, de 30 pacientes com diagnóstico de fratura… (more)

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Este estudo analisou por meio de um eletromiógrafo de superfície as atividades dos músculos masseteres, direito e esquerdo, de 30 pacientes com diagnóstico de fratura de ossos da face, com uma média de 1,33 fraturas por paciente, em quatro momentos, no pré-operatório e nos pós-operatórios equivalentes ao 7°, 30° e 60° dias posteriores à cirurgia. Considerou-se o valor de cada medida, a média entre três contrações máximas isométricas voluntárias de duração de cinco segundos cada uma. Os paciente foram agrupados de acordo com o diagnóstico da fratura, sendo com fratura da mandíbula 50%, fratura do zigomático 33%, fratura da maxila 10% e com fraturas associadas 6,7%. Os pacientes apresentaram menor atividade dos músculo masseter no período pré-operatório, quando comparado a valores considerados normais, em todos os grupos de fraturas, seguida de queda acentuada no pós operatório de 07 dias, sendo que todos os grupos apresentaram recuperação da atividade em 60 dias, porém abaixo do valor normal encontrado na literatura. Os valores médio observados foram em ordem decrescente: fratura de zigomático, fratura de mandíbula, fratura de maxila e fraturas associadas. As fraturas de mandíbulas unilaterais apresentaram maiores valores que as fraturas bilaterais na maioria dos tempos. Houve diferença altamente significante na comparação da evolução da atividade do músculo masseter direito e esquerdo para as fraturas de mandíbula e de zigomático, sendo que na comparação par a par houve diferença significante entre a maioria dos grupos.

This study analyzed using a surface electromyographic activity of the masseter muscles, right and left, of 30 patients with fractures of facial bones, with an average of 1.33 fractures per patient, four times, the pre-operative and postoperative equivalent to the 7th, 30th and 60th days after surgery. It was considered the value of each measurement, the average of three isometric maximum voluntary contractions for five seconds each. Patients were grouped according to the diagnosis of fracture, 50% of the mandible fracture, 33% of the zygomatic fracture, 10% of maxilla fracture and 6,7% with associated fractures. The patients showed lower activity of the masseter muscle in the preoperative period, when compared to normal values in all groups of fractures, followed by a sharp drop in the postoperative period of 07 days, and all groups showed a recovery of activity in 60 days, but below the normal value found in the literature. The average values were observed in decreasing order: zygomatic fracture, mandible fracture, maxilla fracture and associated fractures. The unilateral jaw fractures showed higher values than the bilateral fractures in most of the times. There was a highly significant difference in comparing the evolution of the activity of the masseter muscle right and left to the mandibular and zygomatic fractures, if compared pairwise significant difference between most groups.

Advisors/Committee Members: Luz, Joao Gualberto de Cerqueira.

Subjects/Keywords: Electromyographic surface; Eletromiografia de superfície; Facial fracture; Fratura de face; Masseter muscle; Músculo masseter

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Campolongo, G. D. (2012). Avaliação eletromiográfica do músculo masseter nos pacientes portadores de fratura de face. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/23/23149/tde-11092012-131536/ ;

Chicago Manual of Style (16^th Edition):

Campolongo, Gabriel Denser. “Avaliação eletromiográfica do músculo masseter nos pacientes portadores de fratura de face.” 2012. Doctoral Dissertation, University of São Paulo. Accessed January 21, 2021. http://www.teses.usp.br/teses/disponiveis/23/23149/tde-11092012-131536/ ;.

MLA Handbook (7^th Edition):

Campolongo, Gabriel Denser. “Avaliação eletromiográfica do músculo masseter nos pacientes portadores de fratura de face.” 2012. Web. 21 Jan 2021.

Vancouver:

Campolongo GD. Avaliação eletromiográfica do músculo masseter nos pacientes portadores de fratura de face. [Internet] [Doctoral dissertation]. University of São Paulo; 2012. [cited 2021 Jan 21]. Available from: http://www.teses.usp.br/teses/disponiveis/23/23149/tde-11092012-131536/ ;.

Council of Science Editors:

Campolongo GD. Avaliação eletromiográfica do músculo masseter nos pacientes portadores de fratura de face. [Doctoral Dissertation]. University of São Paulo; 2012. Available from: http://www.teses.usp.br/teses/disponiveis/23/23149/tde-11092012-131536/ ;

University of Kansas

20. Chao, Jie. MECHANISMS OF MICROVASCULAR INFLAMMATION INDUCED BY ALVEOLAR HYPOXIA.

Degree: PhD, Molecular & Integrative Physiology, 2010, University of Kansas

URL: http://hdl.handle.net/1808/7425

► Alveolar hypoxia is observed in a number of clinical settings, and is frequently associated with systemic effects, many of which present an inflammatory component. Reduction… (more)

Subjects/Keywords: Biology; Physiology; Alveolar macrophage; Hypoxia; Inflammation; Mast cell; Mcp-1; Microcirculation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chao, J. (2010). MECHANISMS OF MICROVASCULAR INFLAMMATION INDUCED BY ALVEOLAR HYPOXIA. (Doctoral Dissertation). University of Kansas. Retrieved from http://hdl.handle.net/1808/7425

Chicago Manual of Style (16^th Edition):

Chao, Jie. “MECHANISMS OF MICROVASCULAR INFLAMMATION INDUCED BY ALVEOLAR HYPOXIA.” 2010. Doctoral Dissertation, University of Kansas. Accessed January 21, 2021. http://hdl.handle.net/1808/7425.

MLA Handbook (7^th Edition):

Chao, Jie. “MECHANISMS OF MICROVASCULAR INFLAMMATION INDUCED BY ALVEOLAR HYPOXIA.” 2010. Web. 21 Jan 2021.

Vancouver:

Chao J. MECHANISMS OF MICROVASCULAR INFLAMMATION INDUCED BY ALVEOLAR HYPOXIA. [Internet] [Doctoral dissertation]. University of Kansas; 2010. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/1808/7425.

Council of Science Editors:

Chao J. MECHANISMS OF MICROVASCULAR INFLAMMATION INDUCED BY ALVEOLAR HYPOXIA. [Doctoral Dissertation]. University of Kansas; 2010. Available from: http://hdl.handle.net/1808/7425

Texas A&M University

21. Xu, Hang. Circadian and Metabolic Control of Macrophage Activation in Obesity.

Degree: PhD, Nutrition, 2016, Texas A&M University

URL: http://hdl.handle.net/1969.1/174292

► Macrophage inflammatory status governs inflammatory responses in metabolic tissues including adipose and liver tissues, and critically contributes to the development of diet-induced obesity and systemic… (more)

Subjects/Keywords: Obesity; Macrophage; Circadian; PFKFB3; Inflammation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Xu, H. (2016). Circadian and Metabolic Control of Macrophage Activation in Obesity. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/174292

Chicago Manual of Style (16^th Edition):

Xu, Hang. “Circadian and Metabolic Control of Macrophage Activation in Obesity.” 2016. Doctoral Dissertation, Texas A&M University. Accessed January 21, 2021. http://hdl.handle.net/1969.1/174292.

MLA Handbook (7^th Edition):

Xu, Hang. “Circadian and Metabolic Control of Macrophage Activation in Obesity.” 2016. Web. 21 Jan 2021.

Vancouver:

Xu H. Circadian and Metabolic Control of Macrophage Activation in Obesity. [Internet] [Doctoral dissertation]. Texas A&M University; 2016. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/1969.1/174292.

Council of Science Editors:

Xu H. Circadian and Metabolic Control of Macrophage Activation in Obesity. [Doctoral Dissertation]. Texas A&M University; 2016. Available from: http://hdl.handle.net/1969.1/174292

North Carolina State University

22. Summers, Caroline Rueda. Modulation of Inflammatory Responses by Green and Black Tea in LPS-induced RAW 264.7 Cells.

Degree: MS, Nutrition, 2010, North Carolina State University

URL: http://www.lib.ncsu.edu/resolver/1840.16/6332

► Recently, the World Health Organization estimated that chronic diseases are responsible for 46% of disease occurrence and 59% of all deaths worldwide. Growing evidence suggests… (more)

▼ Recently, the World Health Organization estimated that chronic diseases are responsible for 46% of disease occurrence and 59% of all deaths worldwide. Growing evidence suggests that increasing chronic disease incidence is dependent upon several factors, including inadequate consumption of antioxidant-rich fruits and vegetables and chronic inflammation. Many researchers have previously investigated potential health benefits associated with consuming plant-based foods, and the ability of these foods to prevent or suppress the pathologies linked to chronic diseases. Specifically, plant-based bioactive compounds called polyphenols have been widely studied, and show promise as a therapeutic agent against chronic diseases. Tea is produced from the leaves of the Camellia sinensis plant and, aside from water, is the most popular beverage in the world. Green tea, black tea, and oolong tea are the three major types of commercially produced tea. Black tea comprises over 75% of global tea production and consumption, followed by green tea at approximately 20%, and oolong tea at less than 2%. For centuries, tea has been known for its health effects. It has historically been used as a medicine in China and Japan. Tea polyphenols are particularly thought to have chemopreventive and cardioprotective effects due to their antioxidant and anti-inflammatory properties. Previous in vitro and animal studies have analyzed the anti-inflammatory activity of polyphenols, and the specific mechanisms by which these compounds suppress inflammation. But, to our knowledge, few studies have investigated teaâ€™s anti-inflammatory capacity as a whole food, or compared the potential anti-inflammatory effects of different tea types. Therefore, the objectives of the following study were to evaluate total phenol content in green tea (GT) and black tea (BT); to assess viability of cells exposed to GT, BT, and LPS; and to measure the modulation of inflammatory responses in lipopolysaccharide (LPS)-induced RAW 264.7 mouse macrophages by GT and BT. We predicted that GT and BT would differentially modulate inflammation because of differences in composition. First, the total phenolic content in commercially produced GT and BT was measured using the Folin-Ciocalteu method. Freshly prepared GT had a significantly higher phenolic content than freshly prepared BT (1317.1 + 6.0 GAE, 918.9 + 10.7 GAE). Stored at -80Â° C, the phenolic content of GT and BT significantly increased at one month (1770.0 + 35.2 GAE, 1124.0 + 19.1 GAE) and two months post-preparation (1587.2 + 21.5 GAE, 1003.2 + 8.6 GAE), then decreased at 3 months post-preparation (1407.8 + 13.4 GAE, 941.8 + 0.5 GAE) (p < 0.05). The second goal of our study was to assess viability in RAW 264.7 cells treated with GT, BT, and LPS. Viability was colorimetrically determined by the Trypan Blue assay and by measured absorbance values from the MTT assay. The GT, BT, and LPS treatments did not produce a cytotoxic effect, and cell viability values for each treatment were not significantly… Advisors/Committee Members: Dr. Brenda P. Alston-Mills, Committee Member (advisor), Dr. Jonathan C. Allen, Committee Co-Chair (advisor), Dr. Gabriel Keith Harris, Committee Chair (advisor).

Subjects/Keywords: LPS; tea; mouse macrophage; inflammation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Summers, C. R. (2010). Modulation of Inflammatory Responses by Green and Black Tea in LPS-induced RAW 264.7 Cells. (Thesis). North Carolina State University. Retrieved from http://www.lib.ncsu.edu/resolver/1840.16/6332

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Summers, Caroline Rueda. “Modulation of Inflammatory Responses by Green and Black Tea in LPS-induced RAW 264.7 Cells.” 2010. Thesis, North Carolina State University. Accessed January 21, 2021. http://www.lib.ncsu.edu/resolver/1840.16/6332.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Summers, Caroline Rueda. “Modulation of Inflammatory Responses by Green and Black Tea in LPS-induced RAW 264.7 Cells.” 2010. Web. 21 Jan 2021.

Vancouver:

Summers CR. Modulation of Inflammatory Responses by Green and Black Tea in LPS-induced RAW 264.7 Cells. [Internet] [Thesis]. North Carolina State University; 2010. [cited 2021 Jan 21]. Available from: http://www.lib.ncsu.edu/resolver/1840.16/6332.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Summers CR. Modulation of Inflammatory Responses by Green and Black Tea in LPS-induced RAW 264.7 Cells. [Thesis]. North Carolina State University; 2010. Available from: http://www.lib.ncsu.edu/resolver/1840.16/6332

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Boston College

23. Walker, Joshua Aaron. The Role of Monocytes and Macrophages Pathogenesis of HIV and SIV-Associated Cardiovascular Disease.

Degree: PhD, Biology, 2016, Boston College

URL: http://dlib.bc.edu/islandora/object/bc-ir:107030

► HIV associated cardiovascular disease is likely due to multiple factors ranging from accelerated aging, the direct effects of HIV proteins, and increased inflammation and immune… (more)

Subjects/Keywords: Cardiovascular; HIV; Inflammation; Macrophage; SIV

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Walker, J. A. (2016). The Role of Monocytes and Macrophages Pathogenesis of HIV and SIV-Associated Cardiovascular Disease. (Doctoral Dissertation). Boston College. Retrieved from http://dlib.bc.edu/islandora/object/bc-ir:107030

Chicago Manual of Style (16^th Edition):

Walker, Joshua Aaron. “The Role of Monocytes and Macrophages Pathogenesis of HIV and SIV-Associated Cardiovascular Disease.” 2016. Doctoral Dissertation, Boston College. Accessed January 21, 2021. http://dlib.bc.edu/islandora/object/bc-ir:107030.

MLA Handbook (7^th Edition):

Walker, Joshua Aaron. “The Role of Monocytes and Macrophages Pathogenesis of HIV and SIV-Associated Cardiovascular Disease.” 2016. Web. 21 Jan 2021.

Vancouver:

Walker JA. The Role of Monocytes and Macrophages Pathogenesis of HIV and SIV-Associated Cardiovascular Disease. [Internet] [Doctoral dissertation]. Boston College; 2016. [cited 2021 Jan 21]. Available from: http://dlib.bc.edu/islandora/object/bc-ir:107030.

Council of Science Editors:

Walker JA. The Role of Monocytes and Macrophages Pathogenesis of HIV and SIV-Associated Cardiovascular Disease. [Doctoral Dissertation]. Boston College; 2016. Available from: http://dlib.bc.edu/islandora/object/bc-ir:107030

Boston University

24. Byles, Vanessa A. The role of mammalian target of rapamycin (mTOR) in macrophage polarization.

Degree: MA, Medicine, 2013, Boston University

URL: http://hdl.handle.net/2144/17122

► Macrophages are key orchestrators of the innate immune response with a dynamic role in the promotion and resolution of inflammation. Macrophage polarization to a pro-inflammatory… (more)

▼ Macrophages are key orchestrators of the innate immune response with a dynamic role in the promotion and resolution of inflammation. Macrophage polarization to a pro-inflammatory or anti-inflammatory phenotype must be tightly controlled to maintain appropriate responses to stimuli as well as to maintain tissue homeostasis. The nutrient and energy sensor Mammalian Target of Rapamycin (mTOR) integrates upstream signals from the PI3K/Akt pathway to orchestrate cellular protein, lipid, and glucose metabolism. This key metabolic pathway has been implicated in T-helper cell skewing and in the innate immune regulation. The mechanisms of innate immune regulation by mTOR are currently unclear as most studies use pharmacological inhibitors with potential off target effects. In this study, we use a novel model of TSC1 deficiency in myeloid lineage cells to elucidate a role for mTOR in macrophage polarization. We show, for the first time, that Tsc1-deficiency and constitutive mTORC1 activity in macrophages leads to a marked defect in M2 polarization when stimulated with the Th2 cytokine IL-4. Tsc1-deficient macrophages display attenuated Akt signaling in response to IL-4 consistent with negative feedback of mTORC1 on upstream IRS2/PI3K signaling, and we demonstrate that this parallel signaling pathway is critical for induction of a subset of M2 markers. Tsc1-deficient macrophages fail to upregulate the M2 genes Pgc-1!, Arg-1, Fizz-1, and Mgl1 in addition to other M2 markers despite normal STAT6 signaling in response to IL-4. Consistent with downregulation of Pgc-1!, Tsc1-deficient macrophages also display defects in fatty acid metabolism and mitchochondrial biogenesis. Furthermore, LPS stimulation in Tsc-1 deficient macrophages leads to an enhanced inflammatory response with increased production of pro-inflammatory cytokines. We believe that Tsc1-deficient macrophages are a model of constitutive mTORC1 activity akin to obesity, where chronic nutrient excess leads to increases in mTORC1 activity, attenuation of IRS/PI3K/Akt signaling, and defective M2 polarization of macrophages in metabolic tissues.

Subjects/Keywords: Macrophage; Polarization; Rapamycin (mTOR); Inflammation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Byles, V. A. (2013). The role of mammalian target of rapamycin (mTOR) in macrophage polarization. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/17122

Chicago Manual of Style (16^th Edition):

Byles, Vanessa A. “The role of mammalian target of rapamycin (mTOR) in macrophage polarization.” 2013. Masters Thesis, Boston University. Accessed January 21, 2021. http://hdl.handle.net/2144/17122.

MLA Handbook (7^th Edition):

Byles, Vanessa A. “The role of mammalian target of rapamycin (mTOR) in macrophage polarization.” 2013. Web. 21 Jan 2021.

Vancouver:

Byles VA. The role of mammalian target of rapamycin (mTOR) in macrophage polarization. [Internet] [Masters thesis]. Boston University; 2013. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/2144/17122.

Council of Science Editors:

Byles VA. The role of mammalian target of rapamycin (mTOR) in macrophage polarization. [Masters Thesis]. Boston University; 2013. Available from: http://hdl.handle.net/2144/17122

University of Edinburgh

25. Zhang, Zhenguang. Role of macrophage 11β-HSD1 in inflammation mediated angiogenesis, arthritis and obesity.

Degree: PhD, 2014, University of Edinburgh

URL: http://hdl.handle.net/1842/9553

► 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1, encoded by Hsd11b1) is an enzyme that predominantly converts inactive glucocorticoids (cortisone in human and most mammals, 11dehydro-corticosterone in mice… (more)

▼ 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1, encoded by Hsd11b1) is an enzyme that predominantly converts inactive glucocorticoids (cortisone in human and most mammals, 11dehydro-corticosterone in mice and rats) into their active forms (cortisol and corticosterone, respectively). Thus 11β-HSD1 amplifies intracellular levels of glucocorticoids. Studies in globally 11β-HSD1 deficient mice have revealed changes in glucocorticoid-regulated physiological and pathological processes, including metabolism, aging, arthritis and angiogenesis. The function of macrophages, which play an important role in inflammation, is also altered. For example, 11β-HSD1 deficiency in macrophages causes a delay in their acquisition of phagocytic capacity. To dissect the role of macrophage 11β-HSD1 in angiogenesis, arthritis and obesity, both in vitro macrophage stimulation and in vivo functional assays in macrophage-specific 11β-HSD1 knockout mice, were conducted. Thioglycollate-elicited peritoneal macrophages from globally 11β-HSD1 deficient and control C57BL/6 mice were used for in vitro studies. In M1/M2 macrophage polarisation experiments, 11β-HSD1 deficient macrophages showed increased expression of mRNAs encoding pro-inflammatory factors upon lipopolysaccharide and interferon-ϒ treatment and decreased expression of pro-resolution genes with interleukin-4 stimulation. However, at cytokine or protein levels, there was little difference between the genotypes except for decrease IL12 p40 levels in 11β-HSD1 deficient macrophages. Hypoxic stress failed to show differences between genotypes in hypoxia-regulated gene expression. These data do not support a strong role for macrophage 11β-HSD1 in inflammation regulation, nor in response to hypoxia, at least when measured in vitro. The discrepancy between transcriptional and translational responses is currently unexplained, but may reflect altered posttranscriptional activity. To investigate the role of macrophage 11β-HSD1 in vivo, macrophage-specific Hsd11b1 knockout mice, LysM-Cre Hsd11b1 flox/flox (MKO) mice and Hsd11b1flox/flox littermate controls were generated. In MKO mice, 11β-HSD1 protein levels and enzyme activity were reduced by >80% in resident peritoneal macrophages. However, 11β-HSD1 protein and enzyme activity levels were unchanged or only modestly reduced in thioglycocollate-elicited peritoneal neutrophils, monocytes/macrophages, or in bone marrow-derived macrophages, despite >80% decrease in Hsd11b1 mRNA levels in these cells. A relatively long half-life of 11β-HSD1 protein compared to that of circulating myeloid cells may underlie this mismatch between transcriptional and translational expression. Furthermore, following 12 days of inflammatory arthritis induced by K/BxN serum transfer, the reduction in 11β-HSD1 protein levels in circulating neutrophils of MKO mice is consistently around 50%, which corroborates the above explanation. MKO mice and littermate controls were subjected to inflammatory models which may involve resident macrophages. First, to address the role of…

Subjects/Keywords: 616.07; 11ß-HSD1; macrophage; inflammation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zhang, Z. (2014). Role of macrophage 11β-HSD1 in inflammation mediated angiogenesis, arthritis and obesity. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/9553

Chicago Manual of Style (16^th Edition):

Zhang, Zhenguang. “Role of macrophage 11β-HSD1 in inflammation mediated angiogenesis, arthritis and obesity.” 2014. Doctoral Dissertation, University of Edinburgh. Accessed January 21, 2021. http://hdl.handle.net/1842/9553.

MLA Handbook (7^th Edition):

Zhang, Zhenguang. “Role of macrophage 11β-HSD1 in inflammation mediated angiogenesis, arthritis and obesity.” 2014. Web. 21 Jan 2021.

Vancouver:

Zhang Z. Role of macrophage 11β-HSD1 in inflammation mediated angiogenesis, arthritis and obesity. [Internet] [Doctoral dissertation]. University of Edinburgh; 2014. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/1842/9553.

Council of Science Editors:

Zhang Z. Role of macrophage 11β-HSD1 in inflammation mediated angiogenesis, arthritis and obesity. [Doctoral Dissertation]. University of Edinburgh; 2014. Available from: http://hdl.handle.net/1842/9553

Duke University

26. Stanek IV, Edward John. Premotor Mechanisms for Orofacial Coordination .

Degree: 2016, Duke University

URL: http://hdl.handle.net/10161/12829

► The mouth, throat, and face contain numerous muscles that participate in a large variety of orofacial behaviors. The jaw and tongue can move independently,… (more)

▼ The mouth, throat, and face contain numerous muscles that participate in a large variety of orofacial behaviors. The jaw and tongue can move independently, and thus require a high degree of coordination among the muscles that move them to prevent self-injury. However, different orofacial behaviors require distinct patterns of coordination between these muscles. The method through which motor control circuitry might coordinate this activity has yet to be determined. Electrophysiological, immunohistochemical, and retrograde tracing studies have attempted to identify populations of premotor neurons which directly send information to orofacial motoneurons in an effort to identify sources of coordination. Yet these studies have not provided a complete picture of the population of neurons which monosynaptically connect to jaw and tongue motoneurons. Additionally, while many of these studies have suggested that premotor neurons projecting to multiple motor pools may play a role in coordination of orofacial muscles, no clear functional roles for these neurons in the coordination of natural orofacial movements has been identified. In this dissertation, I took advantage of the recently developed monosynaptic rabies virus to trace the premotor circuits for the jaw-closing masseter muscle and tongue-protruding genioglossus muscle in the neonatal mouse, uncovering novel premotor inputs in the brainstem. Furthermore, these studies identified a set of neurons which form boutons onto motor neurons in multiple motor pools, providing a premotor substrate for orofacial coordination. I then combined a retrogradely traveling lentivirus with a split-intein mediated split-Cre recombinase system to isolate and manipulate a population of neurons which project to both left and right jaw-closing motor nuclei. I found that these bilaterally projecting neurons also innervate multiple other orofacial motor nuclei, premotor regions, and midbrain regions implicated in motor control. I anatomically and physiologically characterized these neurons and used optogenetic and chemicogenetic approaches to assess their role in natural jaw-closing behavior, specifically with reference to bilateral masseter muscle electromyogram (EMG) activity. These studies identified a population of bilaterally projecting neurons in the supratrigeminal nucleus as essential for maintenance of an appropriate level of masseter activation during natural chewing behavior in the freely moving mouse. Moreover, these studies uncovered two distinct roles of supratrigeminal bilaterally projecting neurons in bilaterally synchronized activation of masseter muscles, and active balancing of bilateral masseter muscle tone against an excitatory input. Together, these studies identify neurons which project to multiple motor nuclei as a mechanism by which the brain coordinates orofacial muscles during natural behavior. Advisors/Committee Members: Wang, Fan (advisor), Mooney, Richard (advisor).

Subjects/Keywords: Neurosciences; genioglossus muscle; masseter muscle; monosynaptic rabies virus; muscle tone; orofacial coordination; supratrigeminal nucleus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stanek IV, E. J. (2016). Premotor Mechanisms for Orofacial Coordination . (Thesis). Duke University. Retrieved from http://hdl.handle.net/10161/12829

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Stanek IV, Edward John. “Premotor Mechanisms for Orofacial Coordination .” 2016. Thesis, Duke University. Accessed January 21, 2021. http://hdl.handle.net/10161/12829.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Stanek IV, Edward John. “Premotor Mechanisms for Orofacial Coordination .” 2016. Web. 21 Jan 2021.

Vancouver:

Stanek IV EJ. Premotor Mechanisms for Orofacial Coordination . [Internet] [Thesis]. Duke University; 2016. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/10161/12829.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Stanek IV EJ. Premotor Mechanisms for Orofacial Coordination . [Thesis]. Duke University; 2016. Available from: http://hdl.handle.net/10161/12829

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

27. Lévêque, Manuella. Résolution de l'inflammation - infection dans les macrophages de patients atteints de mucoviscidose : impact de la membrane : Inflammation - infection in macrophages from patients with Cystic Fibrosis : membrane involvement.

Degree: Docteur es, Biologie et sciences de la santé, 2016, Rennes 1

URL: http://www.theses.fr/2016REN1B041

►

Les macrophages sont en première ligne de la défense innée et jouent un rôle important dans l’initiation de la réponse immunitaire puisque régulant l’inflammation et… (more)

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Les macrophages sont en première ligne de la défense innée et jouent un rôle important dans l’initiation de la réponse immunitaire puisque régulant l’inflammation et permettant la clairance des pathogènes. Dans la mucoviscidose, ces phénomènes sont exacerbés et deviennent chronique sans pouvoir être résolus. Les objectifs de cette thèse ont été de déterminer des cibles potentielles responsables des altérations du macrophage dans la mucoviscidose. Dans le contexte inflammatoire, la forme soluble du CD14 (sCD14), dont la sécrétion est augmentée par les macrophages de patients atteints de la mucoviscidose, est caractérisé comme un DAMP puisqu’il contribue à l’entretien de l’inflammation au niveau tissulaire. Dans le contexte infectieux, l’activité de TRPV2, impliqué dans la phagocytose, est altérée. Dans la mucoviscidose, l’inflammation et l’infection sont aussi intimement liées par l’intermédiaire d’une altération des microstructures de la membrane plasmique impliquée dans la production du sCD14 et dans le processus de phagocytose. En conclusion, les modifications des fonctions du macrophage affaiblissent la défense innée des patients atteints de mucoviscidose et peuvent être impliqués dans la progression de la maladie. Par conséquent, les interventions visant à réduire l’inflammation et l’infection pourraient être bénéfiques afin de préserver la fonction pulmonaire des patients. Ainsi, les approches thérapeutiques visant à corriger les dysfonctions du macrophage de patients atteints de mucoviscidose pourrait fournir une meilleure résolution de l'infection et l'inflammation.

Macrophages play a significant role in the initiating stages of immune responses regulating inflammation and clearance of the pathogens. In cystic fibrosis, inability of the macrophage to act as a suppressor cell leading to chronic inflammation/infection cannot be resolved. The aims of this work was to find new targets responsible for alterations in cystic fibrosis macrophages. Regarding inflammation, the soluble form of CD14 (sCD14), find overproduced by cystic fibrosis macrophages, is characterized to be a DAMP as it contributes for maintenance of inflammation in tissues. Regarding infection, the activity of TRPV2, involved in phagocytic capacity of macrophage, is impaired. In cystic fibrosis, inflammation and infection were closely linked to the alteration of the plasma membrane microstructures involved in the production of sCD14 and in the phagocytosis process. In conclusion, the alterations of macrophage weaken innate defense of cystic fibrosis patients and may be involved in cystic fibrosis disease progression and lung damage. Consequently, interventions aimed to reduce ongoing infection and destructive inflammatory response may be beneficial in order to preserve their lung function. In this way, therapeutic approaches aimed to correct cystic fibrosis macrophages dysfunctions might provide improved resolution of infection and inflammation.

Advisors/Committee Members: Chouly-Martin, Corinne (thesis director).

Subjects/Keywords: Mucoviscidose; Macrophage; Inflammation; Infection; Cystic fibrosis; Macrophage; Inflammation; Infection

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lévêque, M. (2016). Résolution de l'inflammation - infection dans les macrophages de patients atteints de mucoviscidose : impact de la membrane : Inflammation - infection in macrophages from patients with Cystic Fibrosis : membrane involvement. (Doctoral Dissertation). Rennes 1. Retrieved from http://www.theses.fr/2016REN1B041

Chicago Manual of Style (16^th Edition):

Lévêque, Manuella. “Résolution de l'inflammation - infection dans les macrophages de patients atteints de mucoviscidose : impact de la membrane : Inflammation - infection in macrophages from patients with Cystic Fibrosis : membrane involvement.” 2016. Doctoral Dissertation, Rennes 1. Accessed January 21, 2021. http://www.theses.fr/2016REN1B041.

MLA Handbook (7^th Edition):

Lévêque, Manuella. “Résolution de l'inflammation - infection dans les macrophages de patients atteints de mucoviscidose : impact de la membrane : Inflammation - infection in macrophages from patients with Cystic Fibrosis : membrane involvement.” 2016. Web. 21 Jan 2021.

Vancouver:

Lévêque M. Résolution de l'inflammation - infection dans les macrophages de patients atteints de mucoviscidose : impact de la membrane : Inflammation - infection in macrophages from patients with Cystic Fibrosis : membrane involvement. [Internet] [Doctoral dissertation]. Rennes 1; 2016. [cited 2021 Jan 21]. Available from: http://www.theses.fr/2016REN1B041.

Council of Science Editors:

Lévêque M. Résolution de l'inflammation - infection dans les macrophages de patients atteints de mucoviscidose : impact de la membrane : Inflammation - infection in macrophages from patients with Cystic Fibrosis : membrane involvement. [Doctoral Dissertation]. Rennes 1; 2016. Available from: http://www.theses.fr/2016REN1B041

Université Paris-Sud – Paris XI

28. Peyvandi, Sanam. Les cellules Myéloïdes Dans le Microenvironnement Tumoral : Rôle de FasL : Myeloid cells in tumoral microenvironnement : Rôle of Fas ligand.

Degree: Docteur es, Immunologie-Cancérologie, 2013, Université Paris-Sud – Paris XI

URL: http://www.theses.fr/2013PA11T042

►

La voie Fas-FasL est la voie majeure d’apoptose dont le rôle est indispensable pour l’homéostasie des cellules hématopoïétiques et la tolérance périphérique. Mon projet de… (more)

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La voie Fas-FasL est la voie majeure d’apoptose dont le rôle est indispensable pour l’homéostasie des cellules hématopoïétiques et la tolérance périphérique. Mon projet de thèse consiste à étudier le rôle de FasL dans la réponse anti tumorale, notamment le rôle de son expression sur les cellules myéloïdes, en l’occurrence les macrophages et les cellules myéloïdes suppressives.Les souris Fasl KO sont caractérisées par une accumulation des différentes populations de cellules hématopoïétiques dans les organes lymphoïdes périphériques. Cependant, elles ne développent pas de tumeurs spontanées. De façon intéressante, nos résultats montrent que lors qu’elles sont transplantées par les cellules tumorales, leur survie est significativement diminuée par rapport aux souris contrôles (Fasl fl/fl), ce qui suggère un rôle de FasL dans la réponse anti-tumorale. Une caractérisation fine de la répartition des cellules myéloïdes chez les souris Fasl KO porteuses de tumeur, montre une répartition différentielle des cellules Gr1+, par une accumulation des M-MDSC, dans la rate de ces souris. En plus, un enrichissement de l’infiltrat tumoral par les macrophages TAM chez les souris Fasl KO a été observé. Ces macrophages, indépendamment de génotype exècrent une forte activité d’arginase et iNOS et une inhibition de la prolifération des cellules T in vitro. Ainsi, la mortalité plus importante chez les souris Fasl KO pourrait, en partie, être associée à cet enrichissement des TAM dans l’infiltrat des souris déficientes en FasL.Afin de déterminer si cette accumulation des cellules myéloïdes immunosuppressives déficientes en FasL est spécifique d’un environnement tumoral ou le reflet d’un état inflammatoire, nous avons examiné le phénotype des macrophages dans un modèle d’inflammation induite par le thioglycollate. Les résultats montrent que les macrophages CD11b+F480+, recrutés sur le site de l’inflammation, lorsqu’elles sont déficientes en FasL, sur-expriment les gènes anti-inflammatoires comme IL-10, Arg1, CCL17. La caractérisation plus fine de cette population de macrophages a montré que la population responsable de ce phénotype suppressive est F480+CD115+IL-4R+. Chez les souris Fasl KO, le pourcentage des macrophages F480+CD115+IL-4R+ est significativement augmenté en comparaison avec les souris contrôles. L’analyse fonctionnelle de cette population CD115+ a montré que ces cellules, inhibent la prolifération et la production d’IFN- des cellules T activées. Ces caractéristiques fonctionnelles sont en faveur d’un phénotype anti-inflammatoire de ces macrophages, qui lorsqu’ils sont déficients en FasL, leur recrutement sur le site de l’inflammation est plus important.L’ensemble de ces résultats suggère que l’expression de FasL sur les cellules myéloïdes pourrait jouer un rôle dans leur polarisation vers un phénotype pro inflammatoire. Ainsi, ce travail pourrait apporter de nouvelles approches de levée de l’immunosuppression pour une immunothérapie efficace.

Fas-FasL pathway is the major pathway of apoptosis, the role of which is essential…

Advisors/Committee Members: Karray, Saoussen (thesis director).

Subjects/Keywords: Fasl; Macrophage; Tumeur; Inflammation; Fasl; Macrophage; Tumor; Inflammation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Peyvandi, S. (2013). Les cellules Myéloïdes Dans le Microenvironnement Tumoral : Rôle de FasL : Myeloid cells in tumoral microenvironnement : Rôle of Fas ligand. (Doctoral Dissertation). Université Paris-Sud – Paris XI. Retrieved from http://www.theses.fr/2013PA11T042

Chicago Manual of Style (16^th Edition):

Peyvandi, Sanam. “Les cellules Myéloïdes Dans le Microenvironnement Tumoral : Rôle de FasL : Myeloid cells in tumoral microenvironnement : Rôle of Fas ligand.” 2013. Doctoral Dissertation, Université Paris-Sud – Paris XI. Accessed January 21, 2021. http://www.theses.fr/2013PA11T042.

MLA Handbook (7^th Edition):

Peyvandi, Sanam. “Les cellules Myéloïdes Dans le Microenvironnement Tumoral : Rôle de FasL : Myeloid cells in tumoral microenvironnement : Rôle of Fas ligand.” 2013. Web. 21 Jan 2021.

Vancouver:

Peyvandi S. Les cellules Myéloïdes Dans le Microenvironnement Tumoral : Rôle de FasL : Myeloid cells in tumoral microenvironnement : Rôle of Fas ligand. [Internet] [Doctoral dissertation]. Université Paris-Sud – Paris XI; 2013. [cited 2021 Jan 21]. Available from: http://www.theses.fr/2013PA11T042.

Council of Science Editors:

Peyvandi S. Les cellules Myéloïdes Dans le Microenvironnement Tumoral : Rôle de FasL : Myeloid cells in tumoral microenvironnement : Rôle of Fas ligand. [Doctoral Dissertation]. Université Paris-Sud – Paris XI; 2013. Available from: http://www.theses.fr/2013PA11T042

29. Iguchi, Hiroko. Changes in muscle activity and physical property of foods with different textures during chewing : 咀嚼中の筋活動ならびに食品物性の変化.

Degree: 博士（歯学）, 2015, Niigata University / 新潟大学

URL: http://hdl.handle.net/10191/35568

►

学位の種類: 博士（歯学）. 報告番号: 甲第4073号. 学位記番号: 新大院博（歯）甲第333号. 学位授与年月日: 平成27年9月24日

This study aimed to investigate how the activity of the masseter (Mas) and suprahyoid (Hyoid) muscle are… (more)

▼

学位の種類: 博士（歯学）. 報告番号: 甲第4073号. 学位記番号: 新大院博（歯）甲第333号. 学位授与年月日: 平成27年9月24日

This study aimed to investigate how the activity of the masseter (Mas) and suprahyoid (Hyoid) muscle are influenced by the condition of food, how changes in rheological property differ in the process of food reduction between different foods, and how different salivary flow rates affect bolus-making capability during chewing in healthy humans. Ten healthy adult males participated. Electromyographic (EMG) recordings were obtained in the Mas and Hyoid muscles, and 15 g steamed rice and rice cake were prepared as test foods. In the ingestion test, the subjects were asked to eat each food in their usual manner. The chewing duration, number of chewing cycles before the first swallow, Mas and Hyoid EMG activity, and chewing cycle time were compared between the foods. The chewing duration was divided into three substages: early, middle, and late; chewing cycle time and EMG activity per chewing cycle of each substage were compared between the foods and among the substages. In the spitting test, the rheological property of the bolus at the end of each substage was compared between the foods and among the substages. Finally, stimulated salivary flow rate was measured and the relationships between the salivary flow rate and chewing duration, EMG activity, changes in the physical properties, and EMG activity were investigated. There were significant differences in the chewing duration and number of chewing cycles between the foods with similar hardness, but not in the chewing cycle time. The Mas and Hyoid EMG activity per chewing cycle for the rice cake was significantly greater than for steamed rice throughout the recording periods. While the Mas activity did not change among the substages during chewing, the Hyoid EMG activity decreased as chewing progressed. Chewing cycle time also gradually decreased as chewing progressed. The hardness of both foods initially increased, then gradually decreased back to baseline. Adhesiveness of the rice cake initially increased, and did not fall throughout the recording period; adhesiveness did not significantly change for the steamed rice. Cohesiveness barely changed for the two foods during chewing, but was significantly greater for the rice cake than for steamed rice. Finally, a correlation between the stimulated salivary flow rate and chewing performance was noted only in change in Mas EMG activity. The current results demonstrate that the Mas and Hyoid muscle activity changed as chewing progressed, and was affected by hardness, adhesiveness, and cohesiveness. Salivary flow rate may affect the changes in Mas activity in the process of bolus formation.

Subjects/Keywords: mastication; masseter muscle; suprahyoid muscles; physical property; electromyography; salivary flow rate

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Iguchi, H. (2015). Changes in muscle activity and physical property of foods with different textures during chewing : 咀嚼中の筋活動ならびに食品物性の変化. (Thesis). Niigata University / 新潟大学. Retrieved from http://hdl.handle.net/10191/35568

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Iguchi, Hiroko. “Changes in muscle activity and physical property of foods with different textures during chewing : 咀嚼中の筋活動ならびに食品物性の変化.” 2015. Thesis, Niigata University / 新潟大学. Accessed January 21, 2021. http://hdl.handle.net/10191/35568.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Iguchi, Hiroko. “Changes in muscle activity and physical property of foods with different textures during chewing : 咀嚼中の筋活動ならびに食品物性の変化.” 2015. Web. 21 Jan 2021.

Vancouver:

Iguchi H. Changes in muscle activity and physical property of foods with different textures during chewing : 咀嚼中の筋活動ならびに食品物性の変化. [Internet] [Thesis]. Niigata University / 新潟大学; 2015. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/10191/35568.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Iguchi H. Changes in muscle activity and physical property of foods with different textures during chewing : 咀嚼中の筋活動ならびに食品物性の変化. [Thesis]. Niigata University / 新潟大学; 2015. Available from: http://hdl.handle.net/10191/35568

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

30. Gheorghe, Teodora-Iunia. An In Vivo Study of the Musculo-Aponeurotic Architecture of Human Masseter Muscle.

Degree: 2018, University of Toronto

URL: http://hdl.handle.net/1807/91406

►

It has been suggested that architectural changes occur in masseter muscle (MM) in conditions of facial pain. To understand pathological changes, it is necessary to… (more)

Subjects/Keywords: aponeuroses; architectural parameter; fiber bundle length; masseter; muscle architecture; ultrasound; 0567

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gheorghe, T. (2018). An In Vivo Study of the Musculo-Aponeurotic Architecture of Human Masseter Muscle. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/91406

Chicago Manual of Style (16^th Edition):

Gheorghe, Teodora-Iunia. “An In Vivo Study of the Musculo-Aponeurotic Architecture of Human Masseter Muscle.” 2018. Masters Thesis, University of Toronto. Accessed January 21, 2021. http://hdl.handle.net/1807/91406.

MLA Handbook (7^th Edition):

Gheorghe, Teodora-Iunia. “An In Vivo Study of the Musculo-Aponeurotic Architecture of Human Masseter Muscle.” 2018. Web. 21 Jan 2021.

Vancouver:

Gheorghe T. An In Vivo Study of the Musculo-Aponeurotic Architecture of Human Masseter Muscle. [Internet] [Masters thesis]. University of Toronto; 2018. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/1807/91406.

Council of Science Editors:

Gheorghe T. An In Vivo Study of the Musculo-Aponeurotic Architecture of Human Masseter Muscle. [Masters Thesis]. University of Toronto; 2018. Available from: http://hdl.handle.net/1807/91406

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