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You searched for subject:(immuno proteasome). Showing records 1 – 2 of 2 total matches.

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Universiteit Utrecht

1. Willems, L. Immunoproteasomes and their functions in immunity and cell viability.

Degree: 2014, Universiteit Utrecht

Proteasomes are large protein complexes capable of degrading poly-ubiquitylated proteins. They function in the degradation of misfolded and damaged proteins and in many other cellular processes. Upon induction of the immunomodulatory cytokine interferon γ, the proteasomal catalytic subunits are substituted for the catalytic immunosubunits. These proteasomes are called immunoproteasomes and possess altered cleavage site specificity. For a long time they have only been implicated in antigen presentation. Immunoproteasomes were shown to be more efficient in the generation of antigenic peptides presented by MHC class I molecules. However, processing of several antigenic peptides required the presence of the standard proteasome and they were destroyed by immunoproteasomes, indicating that immunoproteasomes do not solely function in antigen presentation. Immunoproteasomes have indeed been implicated in other immune-related processes, including cytokine production. Interestingly, immunoproteasome expression has also been observed in non-immune cells and immune-privileged tissues, suggesting a function beyond immunity. Indeed, these proteasomes were found to be more efficient in the clearance of poly-ubiquitylated proteins and aggresomes upon stress and thereby in the maintenance of protein homeostasis and cell viability. Which of the immune or non-immune functions is executed by the immunoproteasomes might be dependent on the cell type expressing these proteasomes. Understanding the mechanisms of immunoproteasome functioning will be an important field of research and may help in the development of new treatments for many diseases. Advisors/Committee Members: Sijts, E.J.A.M..

Subjects/Keywords: (immuno)proteasome; antigen presentation; cytokine production; protein homeostasis; cell viability

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APA (6th Edition):

Willems, L. (2014). Immunoproteasomes and their functions in immunity and cell viability. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/297571

Chicago Manual of Style (16th Edition):

Willems, L. “Immunoproteasomes and their functions in immunity and cell viability.” 2014. Masters Thesis, Universiteit Utrecht. Accessed December 16, 2019. http://dspace.library.uu.nl:8080/handle/1874/297571.

MLA Handbook (7th Edition):

Willems, L. “Immunoproteasomes and their functions in immunity and cell viability.” 2014. Web. 16 Dec 2019.

Vancouver:

Willems L. Immunoproteasomes and their functions in immunity and cell viability. [Internet] [Masters thesis]. Universiteit Utrecht; 2014. [cited 2019 Dec 16]. Available from: http://dspace.library.uu.nl:8080/handle/1874/297571.

Council of Science Editors:

Willems L. Immunoproteasomes and their functions in immunity and cell viability. [Masters Thesis]. Universiteit Utrecht; 2014. Available from: http://dspace.library.uu.nl:8080/handle/1874/297571


University of Oxford

2. Hutchinson, Sarah Louise. Role of the immuno-proteasome in CD8 responses to MCMV.

Degree: PhD, 2009, University of Oxford

Subjects/Keywords: 579.2; Immunology; Viruses; Infectious diseases; Murine cytomegalovirus; immuno-proteasome

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Hutchinson, S. L. (2009). Role of the immuno-proteasome in CD8 responses to MCMV. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:e3bbf79a-95b1-41fd-9f3e-ce55d42fb16c ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.504483

Chicago Manual of Style (16th Edition):

Hutchinson, Sarah Louise. “Role of the immuno-proteasome in CD8 responses to MCMV.” 2009. Doctoral Dissertation, University of Oxford. Accessed December 16, 2019. http://ora.ox.ac.uk/objects/uuid:e3bbf79a-95b1-41fd-9f3e-ce55d42fb16c ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.504483.

MLA Handbook (7th Edition):

Hutchinson, Sarah Louise. “Role of the immuno-proteasome in CD8 responses to MCMV.” 2009. Web. 16 Dec 2019.

Vancouver:

Hutchinson SL. Role of the immuno-proteasome in CD8 responses to MCMV. [Internet] [Doctoral dissertation]. University of Oxford; 2009. [cited 2019 Dec 16]. Available from: http://ora.ox.ac.uk/objects/uuid:e3bbf79a-95b1-41fd-9f3e-ce55d42fb16c ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.504483.

Council of Science Editors:

Hutchinson SL. Role of the immuno-proteasome in CD8 responses to MCMV. [Doctoral Dissertation]. University of Oxford; 2009. Available from: http://ora.ox.ac.uk/objects/uuid:e3bbf79a-95b1-41fd-9f3e-ce55d42fb16c ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.504483

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