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Freie Universität Berlin

1. Reichelt, Ulrike. Epizootiological investigations in horses with Borna disease (BD) in Bavaria and description of the monoclonal antibody 38/15H7.

Degree: 2010, Freie Universität Berlin

In this retrospective study n=451 cases of BD in horses in Bavaria which occurred between 1990 - 2008 were considered for an epizootiologic and diagnostic analysis. 421 cases were diagnosed post mortem as having BD through histological examination and/or immunhistologic tests and/or virus detection. Of the thirty cases not confirmed by post mortem examination, fifteen showed spontaneous recovery. In the remaining fifteen cases, the diagnosis BD was solely based on results from the intra vitam diagnostics. These cases displayed the typical clinical signs, a seropositive titer pair and/or a positive test of the cerebrospinal fluid (CSF). Based on the confirmation by the post mortem examinations, it was possible to evaluate the results from the intra vitam diagnostic methods. Hereby, the significance of the intra vitam diagnostics becomes evident, especially the indirect immunofluorescence test (IIFT) has proven to be a reliable method for the detection of Borna disease virus (BVD) antibodies. The sensitivity of this method for serum is reported to be 89.9%. Furthermore, it is described, that a single detection of antibodies is not sufficient for a diagnosis, only a rise in the titer of the least three steps, within a period of 10 to 14 days, or a seroconversion can be considered indicative of an acute infection. In the majority of the cases, examinating the CSF was a most valuable diagnostic tool. The sensitivity of the diagnostic method in the IIFT was determined to be 85% for CSF. Additionally, the different progressions of BD are shown in this work. It was found, that 93.1% of the BD cases showed acute to subacute development, 3.5% of the cases progressed peracutely and 3.4% healed spontaneously. The epidemiological study consists of an analysis of the BD cases by breed, age, and sex as well as a description of the endemic region. Then an analysis of the secular dynamics and the seasonal rhythm is presented. It is found, that BD affects many breeds, with a disposition for warmbloods, ponies and Haflingers. The results from the age distribution reveal a higher incidence of BD in the group of young horses up to an age of nine years and are most likely related to a normal age structure of the population. The distribution according to sex points to a slightly higher incidence in mares with 54.9%. Evaluation of the secular dynamics of BD during the monitored time span, indicate that there is a rise in cases every 3 - 5 years. This study shows a seasonal increase of BD cases during spring and early summer (April, May, June) and a decrease during August, September, October and November as stated in literature. The study also confirms that BD is a territorial disease. Furthermore, an enlargement as well as a shift of the main endemic area was shown. When comparing the 1990 – 1999 time span to that of 2000 – 2008 a remission of BD cases in the district of Mittelfranken becomes visible, whereas the endemic region expanded to southern and eastern Bavaria. Advisors/Committee Members: w (gender), Univ.-Prof. Dr. Arthur Grabner (firstReferee), Univ.-Prof. Dr. Klaus Osterrieder (furtherReferee), Univ.-Prof. Dr. Leo Brunnberg (furtherReferee).

Subjects/Keywords: borna disease virus; horse diseases; epidemiology; monoclonal antibodies; immunhistology; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA (6th Edition):

Reichelt, U. (2010). Epizootiological investigations in horses with Borna disease (BD) in Bavaria and description of the monoclonal antibody 38/15H7. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/13550

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Reichelt, Ulrike. “Epizootiological investigations in horses with Borna disease (BD) in Bavaria and description of the monoclonal antibody 38/15H7.” 2010. Thesis, Freie Universität Berlin. Accessed September 19, 2020. https://refubium.fu-berlin.de/handle/fub188/13550.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Reichelt, Ulrike. “Epizootiological investigations in horses with Borna disease (BD) in Bavaria and description of the monoclonal antibody 38/15H7.” 2010. Web. 19 Sep 2020.

Vancouver:

Reichelt U. Epizootiological investigations in horses with Borna disease (BD) in Bavaria and description of the monoclonal antibody 38/15H7. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2020 Sep 19]. Available from: https://refubium.fu-berlin.de/handle/fub188/13550.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Reichelt U. Epizootiological investigations in horses with Borna disease (BD) in Bavaria and description of the monoclonal antibody 38/15H7. [Thesis]. Freie Universität Berlin; 2010. Available from: https://refubium.fu-berlin.de/handle/fub188/13550

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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