You searched for subject:(image guided surgery).
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Vanderbilt University
1.
Pheiffer, Thomas Steven.
Surgical Navigation Using Tracked Ultrasound.
Degree: PhD, Biomedical Engineering, 2014, Vanderbilt University
URL: http://hdl.handle.net/1803/12516 
► Ultrasound is an imaging modality which provides spatial measurements of subsurface targets during surgical interventions without the radiation or logistical concerns of CT or MR…
(more)
▼ Ultrasound is an imaging modality which provides spatial measurements of subsurface targets during surgical interventions without the radiation or logistical concerns of CT or MR imaging, respectively. However,
image interpretation is known to be a challenging task without other sources of information. This is not only because of the noise characteristics of ultrasound, but also because manipulation and compression of soft tissue during imaging with an ultrasound probe can distort the size and position of targets. A system for tracking ultrasound images in 3D space was implemented with a novel framework for addressing these issues.
A novel laser range scanner was first characterized with respect to its ability to create textured point clouds tracked in physical space. The geometric point cloud accuracy was determined using phantoms to be submillimetric, and the tracking accuracy of the system was found to be similar to other passive optical tracking tools. This study established a gold standard registration and surface measurement tool to be used in the tracked ultrasound framework.
A strategy was developed for correcting tissue compression by using the pose of the ultrasound probe within the tissue. An initial
image-to-physical registration of the tracked ultrasound to a patient-specific model was done to calculate this pose. After registration, the pose of the probe was used to assign boundary conditions to the tissue model. The solution of the model was then reversed to estimate the tissue in the uncompressed state. This strategy was found to be capable of reducing errors of approximately 1 cm to 2-3 mm.
The correction strategy was then generalized to use a block mesh calibrated to the tip of the ultrasound probe. This strategy did not require a patient-specific mesh, and only required an intraoperative measurement of compression depth. The formulation of the generic model was also significantly faster than the patient-specific method and gave nearly the same correction accuracy. Future work will involve incorporation of accurate material properties into the model correction, as well as real-time surface point cloud information from stereovision cameras.
Advisors/Committee Members: Benoit Dawant (committee member), Bob Galloway (committee member), Brett Byram (committee member), Reid Thompson (committee member), Michael I. Miga (Committee Chair).
Subjects/Keywords: ultrasound; image-guided surgery; finite element modeling
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APA (6th Edition):
Pheiffer, T. S. (2014). Surgical Navigation Using Tracked Ultrasound. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/12516
Chicago Manual of Style (16th Edition):
Pheiffer, Thomas Steven. “Surgical Navigation Using Tracked Ultrasound.” 2014. Doctoral Dissertation, Vanderbilt University. Accessed January 18, 2021.
http://hdl.handle.net/1803/12516.
MLA Handbook (7th Edition):
Pheiffer, Thomas Steven. “Surgical Navigation Using Tracked Ultrasound.” 2014. Web. 18 Jan 2021.
Vancouver:
Pheiffer TS. Surgical Navigation Using Tracked Ultrasound. [Internet] [Doctoral dissertation]. Vanderbilt University; 2014. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/1803/12516.
Council of Science Editors:
Pheiffer TS. Surgical Navigation Using Tracked Ultrasound. [Doctoral Dissertation]. Vanderbilt University; 2014. Available from: http://hdl.handle.net/1803/12516
University of Houston
2.
Kensicher, Thibault H. 1990-.
Towards MRI-Guided and Actuated Tetherless Milli-Robots.
Degree: MS, Computer Science, 2017, University of Houston
URL: http://hdl.handle.net/10657/4568
► Image-guided and robot-assisted surgical procedures are rapidly evolving due to their potential to improve patient management and cost effectiveness. Magnetic Resonance Imaging (MRI) is used…
(more)
▼ Image-
guided and robot-assisted surgical procedures are rapidly evolving due to their potential to improve patient management and cost effectiveness. Magnetic Resonance Imaging (MRI) is used for pre-operative planning and is also investigated for realtime intra-operative guidance. A new type of technology is emerging that uses the magnetic-field gradients of the MR scanner to maneuver ferromagnetic agents for local delivery of therapeutics. With this approach, MRI is both a sensor and forms a closed-loop controlled entity that behaves as a robot (we refer to them as MRbots). The objective of this thesis is to introduce a computational framework for preoperative planning using MRI and modeling of MRbot maneuvering inside tortuous blood vessels. This platform generates a virtual corridor that represents a safety zone inside the vessel that is then used to access the safety of the MRbot maneuvering. In addition, to improve safety we introduce a control that sets speed based on the local curvature of the vessel. The functionality of the framework was then tested on a realistic operational scenario of accessing a neurological lesion, a meningioma. This virtual case study demonstrated the functionality and potential of MRbots as well as revealed two primary challenges: real-time MRI (during propulsion) and the need of very-strong gradients for small MRbots for maneuvering inside narrow cerebral vessels. Our ongoing research focuses on further developing the computational core, MR tracking methods, and on-line interfacing to the MR scanner.
Advisors/Committee Members: Tsekos, Nikolaos V. (advisor), Becker, Aaron T. (committee member), Leiss, Ernst L. (committee member).
Subjects/Keywords: MRI; Image Guided Surgery; MR-actuated Robot
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APA (6th Edition):
Kensicher, T. H. 1. (2017). Towards MRI-Guided and Actuated Tetherless Milli-Robots. (Masters Thesis). University of Houston. Retrieved from http://hdl.handle.net/10657/4568
Chicago Manual of Style (16th Edition):
Kensicher, Thibault H 1990-. “Towards MRI-Guided and Actuated Tetherless Milli-Robots.” 2017. Masters Thesis, University of Houston. Accessed January 18, 2021.
http://hdl.handle.net/10657/4568.
MLA Handbook (7th Edition):
Kensicher, Thibault H 1990-. “Towards MRI-Guided and Actuated Tetherless Milli-Robots.” 2017. Web. 18 Jan 2021.
Vancouver:
Kensicher TH1. Towards MRI-Guided and Actuated Tetherless Milli-Robots. [Internet] [Masters thesis]. University of Houston; 2017. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/10657/4568.
Council of Science Editors:
Kensicher TH1. Towards MRI-Guided and Actuated Tetherless Milli-Robots. [Masters Thesis]. University of Houston; 2017. Available from: http://hdl.handle.net/10657/4568
University of Toronto
3.
Guha, Daipayan.
Feasibility of Spinal Neuronavigation and Evaluation of Registration and Application Error Modalities Using Optical Topographic Imaging.
Degree: PhD, 2018, University of Toronto
URL: http://hdl.handle.net/1807/97774
► Intra-operative navigation began with the localization of subsurface structures in cranial neurosurgery using frame-based stereotaxy. Advances in imaging and computing power have led to the…
(more)
▼ Intra-operative navigation began with the localization of subsurface structures in cranial neurosurgery using frame-based stereotaxy. Advances in imaging and computing power have led to the development of modern frameless three-dimensional (3D) computer-assisted navigation (CAN), employed across multiple surgical disciplines. In spinal surgery, CAN may guide implant placement, bony decompression and soft-tissue resection. However, adoption of 3D CAN by spinal surgeons has been limited by cumbersome registration protocols, workflow disruption, high capital cost, and questionable quantitative and clinical utility. A novel technique for image-to-patient registration has recently been developed, based on optical topographic imaging (OTI). Whether OTI-based CAN is able to provide accurate intra-operative image-guidance for common spinal procedures, while addressing current limitations of CAN techniques, warrants study. First, we explored the current paradigms of reporting CAN accuracy in the context of spinal procedures, finding that quantitative application accuracy and radiographic screw placement do not correlate. We therefore proposed a combined quantitative and radiographic system of reporting CAN accuracy. Second, we examined the registration workflow and accuracy of OTI-CAN in open posterior thoracolumbar instrumentation, in pre-clinical swine and cadaveric models and subsequently in clinical in-vivo testing. We found that OTI-CAN is comparably accurate to but significantly faster than existing 3D CAN techniques. We subsequently found that OTI-CAN was similarly accurate, with maintained workflow improvements, in minimally-invasive (MIS) thoracolumbar and open cervical approaches. Finally, we explored mechanisms by which current CAN and specifically surface-based registration techniques, including OTI, may fail. We found that navigation error increases with greater working distance to the dynamic reference frame (DRF), and with greater geometric symmetry over the osseous posterior elements. Taken together, this body of work demonstrates that OTI is a feasible technique for spinal CAN, and may alleviate the primary issues plaguing current systems to allow increased adoption into settings where CAN may be most useful.
2019-11-16 00:00:00
Advisors/Committee Members: Yang, Victor XD, Medical Science.
Subjects/Keywords: Image guided surgery; Navigation; Spine; 0576
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APA (6th Edition):
Guha, D. (2018). Feasibility of Spinal Neuronavigation and Evaluation of Registration and Application Error Modalities Using Optical Topographic Imaging. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/97774
Chicago Manual of Style (16th Edition):
Guha, Daipayan. “Feasibility of Spinal Neuronavigation and Evaluation of Registration and Application Error Modalities Using Optical Topographic Imaging.” 2018. Doctoral Dissertation, University of Toronto. Accessed January 18, 2021.
http://hdl.handle.net/1807/97774.
MLA Handbook (7th Edition):
Guha, Daipayan. “Feasibility of Spinal Neuronavigation and Evaluation of Registration and Application Error Modalities Using Optical Topographic Imaging.” 2018. Web. 18 Jan 2021.
Vancouver:
Guha D. Feasibility of Spinal Neuronavigation and Evaluation of Registration and Application Error Modalities Using Optical Topographic Imaging. [Internet] [Doctoral dissertation]. University of Toronto; 2018. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/1807/97774.
Council of Science Editors:
Guha D. Feasibility of Spinal Neuronavigation and Evaluation of Registration and Application Error Modalities Using Optical Topographic Imaging. [Doctoral Dissertation]. University of Toronto; 2018. Available from: http://hdl.handle.net/1807/97774
University of Oxford
4.
Barnes, Thomas George.
Uses of near-infrared light for real time image guided surgery.
Degree: PhD, 2019, University of Oxford
URL: http://ora.ox.ac.uk/objects/uuid:64e8fece-ee57-4e8a-b308-22c8c2d02735
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780704
► Fluorescence is a technology where a fluorophore is excited by light at a specific wavelength and light is emitted at a longer wavelength and can…
(more)
▼ Fluorescence is a technology where a fluorophore is excited by light at a specific wavelength and light is emitted at a longer wavelength and can be detected. This has been applied for imaging in surgery because in the near infra-red spectrum, light can penetrate through overlying tissue and provide information to the surgeon about underlying structures. Two important applications of fluorescence include identification of critical anatomical structures to prevent injury and guide dissection, and identification of tumours to aid diagnostics. During colorectal surgery, it is essential for surgeons to be aware of the location of the structures in the urinary tract. The ureter is an essential landmark of the correct dissection plane as well as its injury being a devastating complication. To date, fluorescence identification of the ureter has only been described in technical papers. This thesis explores ureteric fluorescence further with a large cohort of patients using methylene blue and a first in man study assessing IRDye 800BK (Chapter 3). Urethral identification with NIR light is also explored from proof of principle to in vivo assessment using methylene blue, ICG and a NIR light emitting device (Chapter 4). During oesophagectomy, the thoracic duct can be injured complicating the post-operative course with chylothorax. Fluorescence of the duct for prevention and identification of intraoperative injuries is, for the first time, described (Chapter 5). Finally, WFA as a target for sugars in the mucus is explored to highlight cancer and dysplasia during colonoscopy and TEMS. Autofluorescence in the colon provides difficulties in fluorescent imaging and is explored as well as the struggles with utilising mucus as a target with WFA. However, an additional potential marker, GPA33, could provide a future for in vivo colonic imaging.
Subjects/Keywords: Molecular imaging; Fluorescence; Fluorescence guided surgery; Virtual reality; Image guided surgery; Surgery
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APA (6th Edition):
Barnes, T. G. (2019). Uses of near-infrared light for real time image guided surgery. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:64e8fece-ee57-4e8a-b308-22c8c2d02735 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780704
Chicago Manual of Style (16th Edition):
Barnes, Thomas George. “Uses of near-infrared light for real time image guided surgery.” 2019. Doctoral Dissertation, University of Oxford. Accessed January 18, 2021.
http://ora.ox.ac.uk/objects/uuid:64e8fece-ee57-4e8a-b308-22c8c2d02735 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780704.
MLA Handbook (7th Edition):
Barnes, Thomas George. “Uses of near-infrared light for real time image guided surgery.” 2019. Web. 18 Jan 2021.
Vancouver:
Barnes TG. Uses of near-infrared light for real time image guided surgery. [Internet] [Doctoral dissertation]. University of Oxford; 2019. [cited 2021 Jan 18].
Available from: http://ora.ox.ac.uk/objects/uuid:64e8fece-ee57-4e8a-b308-22c8c2d02735 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780704.
Council of Science Editors:
Barnes TG. Uses of near-infrared light for real time image guided surgery. [Doctoral Dissertation]. University of Oxford; 2019. Available from: http://ora.ox.ac.uk/objects/uuid:64e8fece-ee57-4e8a-b308-22c8c2d02735 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780704
UCLA
5.
Cheng, Harrison.
Translational Research for Biophotonics Image-Guided Surgery.
Degree: Bioengineering, 2018, UCLA
URL: http://www.escholarship.org/uc/item/06h07815
► There are many challenges to translating bench-top research biophotonics imaging system into the clinical setting. One commonality amongst many of these systems is that they…
(more)
▼ There are many challenges to translating bench-top research biophotonics imaging system into the clinical setting. One commonality amongst many of these systems is that they fall short in the final in vivo clinical translation, which is the most critical step to truly have aclinical impact. The intent of this PhD thesis is to offer a comprehensive view of a project cycle and to provide insight that are important to successful clinical translation of research systems into the clinic setting. Many of these issues are typically neglected in academic setting due to the lack of academic novelty and publication possibilities; but is necessary for successful clinical translation. Some of these issues includes poor clinical practicality, high system complexity, and inconsistent results. The thesis will use the system development and clinical translation of Dynamic Optical Contrast Imaging (DOCi), a novel imaging system that uses fluorescence decay as the contrast mechanism to differentiate tissue types; as an example to address translational challenges. The research can be divided into a few distinct sections such as the development of DOCi system, challenges and considerations for clinical translation, and algorithm development for image processing and interpreting data. Each of the sections will entail solutions to improve clinical practicality, reduce system complexity,or attempts to standardize results across multiple systems.
Subjects/Keywords: Biomedical engineering; Electrical engineering; Surgery; Biophotonics; Image-Guided Surgery; Translational Research
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APA (6th Edition):
Cheng, H. (2018). Translational Research for Biophotonics Image-Guided Surgery. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/06h07815
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Cheng, Harrison. “Translational Research for Biophotonics Image-Guided Surgery.” 2018. Thesis, UCLA. Accessed January 18, 2021.
http://www.escholarship.org/uc/item/06h07815.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Cheng, Harrison. “Translational Research for Biophotonics Image-Guided Surgery.” 2018. Web. 18 Jan 2021.
Vancouver:
Cheng H. Translational Research for Biophotonics Image-Guided Surgery. [Internet] [Thesis]. UCLA; 2018. [cited 2021 Jan 18].
Available from: http://www.escholarship.org/uc/item/06h07815.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Cheng H. Translational Research for Biophotonics Image-Guided Surgery. [Thesis]. UCLA; 2018. Available from: http://www.escholarship.org/uc/item/06h07815
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Toronto
6.
Manbachi, Amir.
On the Development of a 2MHz Radial Imaging Ultrasound Array for Potential Use in Guiding Pedicle Screw Insertion.
Degree: PhD, 2015, University of Toronto
URL: http://hdl.handle.net/1807/69430
► Spinal fusion surgeries often require the insertion of screw implants into the pedicle bone. Although the procedure is somewhat routine, there is an inherent error…
(more)
▼ Spinal fusion surgeries often require the insertion of screw implants into the pedicle bone. Although the procedure is somewhat routine, there is an inherent error rate when surgeons employ manual feedback techniques in the operating room. An alternative
image guidance technique to reduce the error rate is an ultrasound transducer, which could be incorporated with the surgical toolkit to
image the pedicle bone from within. This allows for real-time, non-radiating visualization of the anatomy and bone boundaries relative to the tip of the toolkit.
The primary objective of this thesis is to describe the design and fabrication of 2MHz ultrasound probes for pedicle screw guidance. Three single-element transducer designs (3.5mm diameter) are explored in order to arrive at an acoustic design (backing, active, matching layer) that enables intra-pedicular imaging. To eliminate the need for manual rotation of the transducer, we have successfully designed and fabricated a 2MHz radial array that consists of 32 elements (3.2mm outer diameter). Using a commercial platform, we have obtained radial images from successive groupings of four array elements, when the array was placed in various fluids. Although this work has not demonstrated intra-pedicular imaging, we believe that it represents an important step in this direction.
A secondary objective of this work is to investigate the directionality distribution in the pedicle's trabecular bone. This stems from the need to better understand the manner in which it can affect ultrasound propagation. In this thesis, we have estimated the direction distribution of pedicle trabecular bone from micro-CT images using Gabor filters. The Gabor filter was tested for suitability in detecting trabecular structures first through simulated 2-D line tests then through 3-D bone models. When applied to micro-CT images of six human pedicle bones, the final results are an estimation of the main directions of trabecular structures in both the coronal and sagittal planes. However, since the pedicles tested were from just one cadaver, more general conclusions cannot be drawn concerning the directionality distribution. Nonetheless, a reliable quantitative method has been developed that should have considerable potential in a variety of applications.
Advisors/Committee Members: Cobbold, Richard S.C., Ginsberg, Howard J., Biomedical Engineering.
Subjects/Keywords: Bone; Image guided surgery; Imaging Arrays; Spine Surgery; Transducers; Ultrasound; 0541
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APA (6th Edition):
Manbachi, A. (2015). On the Development of a 2MHz Radial Imaging Ultrasound Array for Potential Use in Guiding Pedicle Screw Insertion. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/69430
Chicago Manual of Style (16th Edition):
Manbachi, Amir. “On the Development of a 2MHz Radial Imaging Ultrasound Array for Potential Use in Guiding Pedicle Screw Insertion.” 2015. Doctoral Dissertation, University of Toronto. Accessed January 18, 2021.
http://hdl.handle.net/1807/69430.
MLA Handbook (7th Edition):
Manbachi, Amir. “On the Development of a 2MHz Radial Imaging Ultrasound Array for Potential Use in Guiding Pedicle Screw Insertion.” 2015. Web. 18 Jan 2021.
Vancouver:
Manbachi A. On the Development of a 2MHz Radial Imaging Ultrasound Array for Potential Use in Guiding Pedicle Screw Insertion. [Internet] [Doctoral dissertation]. University of Toronto; 2015. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/1807/69430.
Council of Science Editors:
Manbachi A. On the Development of a 2MHz Radial Imaging Ultrasound Array for Potential Use in Guiding Pedicle Screw Insertion. [Doctoral Dissertation]. University of Toronto; 2015. Available from: http://hdl.handle.net/1807/69430
Vanderbilt University
7.
Collins, Jarrod Alan.
Uncertainty in Image-to-Physical Registration for Soft-Tissue Image Guided Surgery.
Degree: MS, Biomedical Engineering, 2015, Vanderbilt University
URL: http://hdl.handle.net/1803/14664
► Image-guided surgical methods have been investigated as techniques to increase the localization accuracy of hepatic cancer treatments such as resection and ablation. Mathematical registration methods…
(more)
▼ Image-
guided surgical methods have been investigated as techniques to increase the localization accuracy of hepatic cancer treatments such as resection and ablation. Mathematical registration methods are currently used to align intraoperative physical space with preoperative
image space, providing the physician with more information in the surgical setting. These methods rely upon accurate digitization of the intraoperative organ surface. Across the data collection of a series of clinical cases, we observed a high variability in the pattern and density of acquired surfaces. The goal of this work was to characterize the extent to which variation of input data affects the output of
image-to-physical registration methods. In order to do so, a data set consisting of multiple realistic surface acquisitions of the same intraoperative organ was realized by virtually projecting the collection pattern of 14 clinically acquired hepatic surfaces onto an anthropomorphic liver phantom. With this simulated set of data, we observed that varying surface collection has an effect on the accuracy and repeatability of registration methods. In addition, a strategy for normalizing, or resampling, collected surface data was developed and applied to the simulated data sets. Results of this work suggest (1) the technique of surface acquisition has downstream effects on registration error and (2) a surface resampling strategy may be used to normalize data acquisition across cases, and users, to further increase the accuracy of current clinical methods.
Advisors/Committee Members: Robert L Galloway (committee member), Michael I Miga (Committee Chair).
Subjects/Keywords: surgical navigation; registration; surface registration; image guided liver surgery; image-guidance
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Manager
APA (6th Edition):
Collins, J. A. (2015). Uncertainty in Image-to-Physical Registration for Soft-Tissue Image Guided Surgery. (Thesis). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/14664
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Collins, Jarrod Alan. “Uncertainty in Image-to-Physical Registration for Soft-Tissue Image Guided Surgery.” 2015. Thesis, Vanderbilt University. Accessed January 18, 2021.
http://hdl.handle.net/1803/14664.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Collins, Jarrod Alan. “Uncertainty in Image-to-Physical Registration for Soft-Tissue Image Guided Surgery.” 2015. Web. 18 Jan 2021.
Vancouver:
Collins JA. Uncertainty in Image-to-Physical Registration for Soft-Tissue Image Guided Surgery. [Internet] [Thesis]. Vanderbilt University; 2015. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/1803/14664.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Collins JA. Uncertainty in Image-to-Physical Registration for Soft-Tissue Image Guided Surgery. [Thesis]. Vanderbilt University; 2015. Available from: http://hdl.handle.net/1803/14664
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Vanderbilt University
8.
Kumar, Ankur N.
Quantifying in vivo motion in video sequences using image registration.
Degree: PhD, Electrical Engineering, 2014, Vanderbilt University
URL: http://hdl.handle.net/1803/14690
► Image registration is a pivotal part of many medical imaging analysis systems that provide clinically relevant medical information. One fundamental problem addressed by image registration…
(more)
▼ Image registration is a pivotal part of many medical imaging analysis systems that provide clinically relevant medical information. One fundamental problem addressed by
image registration is the accounting of a subject’s motion. This dissertation broadly addresses the problem of quantifying in vivo motion in video sequences for two different applications using
image registration. The first problem involves the correction of motion in in vivo time-series microscopy imaging of islets of Langerhans in mice. The second problem focuses on delivering near real-time 3D intraoperative movements of the cortical surface to a computational biomechanical model framework for the compensation of brain shift during brain tumor
surgery. For the first application, a fully automatic algorithm is developed for the correction of in vivo time-series microscopy images of islets of Langerhans. The second application focuses on delivering near real-time 3D intraoperative movements of the cortical surface to a computational biomechanical model framework for the compensation of brain shift during brain tumor
surgery. This dissertation demonstrates a clinical microscope-based digitization platform capable of reliably providing temporally dense 3D textured point clouds in near real-time of the FOV for the entire duration and under realistic conditions of neurosurgery. A fully automatic technique has been developed for robustly digitizing 3D points intraoperatively using an operating microscope at 1Hz. Another algorithm has been developed for tracking points on the cortical surface intraoperatively, which can potentially deliver intraoperative 3D displacements of the cortical surface at different time points during brain tumor
surgery.
Advisors/Committee Members: Dr. Michael Miga (committee member), Dr. Reid Thompson (committee member), Dr. Alan Peters (committee member), Dr. Bobby Bodenheimer (committee member), Dr. Dave Piston (committee member), Dr. Benoit Dawant (Committee Chair).
Subjects/Keywords: stereovision; image registration; in vivo; brain tumor surgery; image guided surgery; magnification
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APA (6th Edition):
Kumar, A. N. (2014). Quantifying in vivo motion in video sequences using image registration. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/14690
Chicago Manual of Style (16th Edition):
Kumar, Ankur N. “Quantifying in vivo motion in video sequences using image registration.” 2014. Doctoral Dissertation, Vanderbilt University. Accessed January 18, 2021.
http://hdl.handle.net/1803/14690.
MLA Handbook (7th Edition):
Kumar, Ankur N. “Quantifying in vivo motion in video sequences using image registration.” 2014. Web. 18 Jan 2021.
Vancouver:
Kumar AN. Quantifying in vivo motion in video sequences using image registration. [Internet] [Doctoral dissertation]. Vanderbilt University; 2014. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/1803/14690.
Council of Science Editors:
Kumar AN. Quantifying in vivo motion in video sequences using image registration. [Doctoral Dissertation]. Vanderbilt University; 2014. Available from: http://hdl.handle.net/1803/14690
Vanderbilt University
9.
Ding, Siyi.
Intraoperative brain shift estimation using vessel segmentation registration and tracking.
Degree: PhD, Electrical Engineering, 2011, Vanderbilt University
URL: http://hdl.handle.net/1803/11393
► A typical image-guided neurosurgery system (IGNS) presents images acquired pre-operatively to the surgeons to assist in planning and executing the procedure. The major issue with…
(more)
▼ A typical
image-
guided neurosurgery system (IGNS) presents images acquired pre-operatively to the surgeons to assist in planning and executing the procedure. The major issue with IGNSs is the fact that the brain shifts during the procedure due to a number of reasons ranging from loss of cerebrospinal fluid, medications, and/or resection of abnormal tissues. Updating the pre-operative images to compensate for brain shift using computational models is an active area of research. In this dissertation, we have developed and evaluated techniques that permit estimating cortical displacements from laser range scanner (LRS) images and intra-operative microscope video sequences. Cortical displacements can be used subsequently as input to computational models. The set of techniques that were developed include novel vessel segmentation algorithms, new registration methods for pre- and post-resection LRS data and new tracking algorithms for microscope video sequences recorded during a tumor resection
surgery. Results show that combining LRS images and video sequences is a promising approach to estimate intra-operative brain shift.
Advisors/Committee Members: Reid C. Thompson (committee member), Bobby Bodenheimer (committee member), J. Michael Fitzpatrick (committee member), Benoit M. Dawant (Committee Chair), michael I. Miga (Committee Chair).
Subjects/Keywords: tracking; segmentation; registration; image guided surgery; brain shift
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APA (6th Edition):
Ding, S. (2011). Intraoperative brain shift estimation using vessel segmentation registration and tracking. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/11393
Chicago Manual of Style (16th Edition):
Ding, Siyi. “Intraoperative brain shift estimation using vessel segmentation registration and tracking.” 2011. Doctoral Dissertation, Vanderbilt University. Accessed January 18, 2021.
http://hdl.handle.net/1803/11393.
MLA Handbook (7th Edition):
Ding, Siyi. “Intraoperative brain shift estimation using vessel segmentation registration and tracking.” 2011. Web. 18 Jan 2021.
Vancouver:
Ding S. Intraoperative brain shift estimation using vessel segmentation registration and tracking. [Internet] [Doctoral dissertation]. Vanderbilt University; 2011. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/1803/11393.
Council of Science Editors:
Ding S. Intraoperative brain shift estimation using vessel segmentation registration and tracking. [Doctoral Dissertation]. Vanderbilt University; 2011. Available from: http://hdl.handle.net/1803/11393
Washington University in St. Louis
10.
Mondal, Suman Bikash.
Goggle Augmented Imaging and Navigation System for Fluorescence-Guided Surgery.
Degree: PhD, Biomedical Engineering, 2016, Washington University in St. Louis
URL: https://openscholarship.wustl.edu/eng_etds/173
► Surgery remains the only curative option for most solid tumors. The standard-of-care usually involves tumor resection and sentinel lymph node biopsy for cancer staging.…
(more)
▼ Surgery remains the only curative option for most solid tumors. The standard-of-care usually involves tumor resection and sentinel lymph node biopsy for cancer staging. Surgeons rely on their vision and touch to distinguish healthy from cancer tissue during
surgery, often leading to incomplete tumor resection that necessitates repeat
surgery. Sentinel lymph node biopsy by conventional radioactive tracking exposes patients and caregivers to ionizing radiation, while blue dye tracking stains the tissue highlighting only superficial lymph nodes. Improper identification of sentinel lymph nodes may misdiagnose the stage of the cancer. Therefore there is a clinical need for accurate intraoperative tumor and sentinel lymph node visualization.
Conventional imaging modalities such as x-ray computed tomography, positron emission tomography, magnetic resonance imaging, and ultrasound are excellent for preoperative cancer diagnosis and surgical planning. However, they are not suitable for intraoperative use, due to bulky complicated hardware, high cost, non-real-time imaging, severe restrictions to the surgical workflow and lack of sufficient resolution for tumor boundary assessment. This has propelled interest in fluorescence-
guided surgery, due to availability of simple hardware that can achieve real-time, high resolution and sensitive imaging. Near-infrared fluorescence imaging is of particular interest due to low background absorbance by photoactive biomolecules, enabling thick tissue assessment. As a result several near-infrared fluorescence-
guided surgery systems have been developed. However, they are limited by bulky hardware, disruptive information display and non-matched field of view to the user.
To address these limitations we have developed a compact, light-weight and wearable goggle augmented imaging and navigation system (GAINS). It detects the near-infrared fluorescence from a tumor accumulated contrast agent, along with the normal color view and displays accurately aligned, color-fluorescence images via a head-mounted display worn by the surgeon, in real-time. GAINS is a platform technology and capable of very sensitive fluorescence detection.
Image display options include both video see-through and optical see-through head-mounted displays for high-contrast
image guidance as well as direct visual access to the surgical bed.
Image capture options from large field of view camera as well high magnification handheld microscope, ensures macroscopic as well as microscopic assessment of the tumor bed. Aided by tumor targeted near-infrared contrast agents, GAINS
guided complete tumor resection in subcutaneous, metastatic and spontaneous mouse models of cancer with high sensitivity and specificity, in real-time. Using a clinically-approved near-infrared contrast agent, GAINS provided real-time
image guidance for accurate visualization of lymph nodes in a porcine model and sentinel lymph nodes in human breast cancer and melanoma patients with high sensitivity. This work has addressed issues that have…
Advisors/Committee Members: Samuel Achilefu, Lihong Wang, Mark Anastasio, Joseph Culver, Viktor Gruev.
Subjects/Keywords: Fluorescence imaging; Image-guided surgery; Real-time imaging; Biomedical; Optics
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APA (6th Edition):
Mondal, S. B. (2016). Goggle Augmented Imaging and Navigation System for Fluorescence-Guided Surgery. (Doctoral Dissertation). Washington University in St. Louis. Retrieved from https://openscholarship.wustl.edu/eng_etds/173
Chicago Manual of Style (16th Edition):
Mondal, Suman Bikash. “Goggle Augmented Imaging and Navigation System for Fluorescence-Guided Surgery.” 2016. Doctoral Dissertation, Washington University in St. Louis. Accessed January 18, 2021.
https://openscholarship.wustl.edu/eng_etds/173.
MLA Handbook (7th Edition):
Mondal, Suman Bikash. “Goggle Augmented Imaging and Navigation System for Fluorescence-Guided Surgery.” 2016. Web. 18 Jan 2021.
Vancouver:
Mondal SB. Goggle Augmented Imaging and Navigation System for Fluorescence-Guided Surgery. [Internet] [Doctoral dissertation]. Washington University in St. Louis; 2016. [cited 2021 Jan 18].
Available from: https://openscholarship.wustl.edu/eng_etds/173.
Council of Science Editors:
Mondal SB. Goggle Augmented Imaging and Navigation System for Fluorescence-Guided Surgery. [Doctoral Dissertation]. Washington University in St. Louis; 2016. Available from: https://openscholarship.wustl.edu/eng_etds/173
11.
Ji, Wenzhi.
Reconfigurable Fiducial-Integrated Modular Needle Driver For MRI-Guided Percutaneous Interventions.
Degree: MS, 2013, Worcester Polytechnic Institute
URL: etd-042513-154212
;
https://digitalcommons.wpi.edu/etd-theses/303
► Needle-based interventions are pervasive in Minimally Invasive Surgery (MIS), and are often used in a number of diagnostic and therapeutic procedures, including biopsy and brachytherapy…
(more)
▼ Needle-based interventions are pervasive in Minimally Invasive
Surgery (MIS), and are often used in a number of diagnostic and therapeutic procedures, including biopsy and brachytherapy seed placement. Magnetic Resonance Imaging (MRI) which can provide high quality, real time and high soft tissue contrast imaging, is an ideal guidance tool for
image-
guided therapy (IGT). Therefore, a MRI-
guided needle-based surgical robot proves to have great potential in the application of percutaneous interventions. Presented here is the design of reconfigurable fiducial-integrated modular needle driver for MRI-
guided percutaneous interventions. Further, an MRI-compatible hardware control system has been developed and enhanced to drive piezoelectric ultrasonic motors for a previously developed base robot designed to support the modular needle driver. A further contribution is the development of a fiber optic sensing system to detect robot position and joint limits. A transformer printed circuit board (PCB) and an interface board with integrated fiber optic limit sensing have been developed and tested to integrate the robot with the piezoelectric actuator control system designed by AIM Lab for closed loop control of ultrasonic Shinsei motors. A series of experiments were performed to evaluate the feasibility and accuracy of the modular needle driver. Bench top tests were conducted to validate the transformer board, fiber optic limit sensing and interface board in a lab environment. Finally, the whole robot control system was tested inside the MRI room to evaluate its MRI compatibility and stability.
Advisors/Committee Members: Stephen S. Nestinger, Committee Member, Glenn R. Gaudette, Committee Member, Gregory S. Fischer, Advisor.
Subjects/Keywords: medical robot; MRI; needle steering; image-guided surgery; registration
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APA (6th Edition):
Ji, W. (2013). Reconfigurable Fiducial-Integrated Modular Needle Driver For MRI-Guided Percutaneous Interventions. (Thesis). Worcester Polytechnic Institute. Retrieved from etd-042513-154212 ; https://digitalcommons.wpi.edu/etd-theses/303
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Ji, Wenzhi. “Reconfigurable Fiducial-Integrated Modular Needle Driver For MRI-Guided Percutaneous Interventions.” 2013. Thesis, Worcester Polytechnic Institute. Accessed January 18, 2021.
etd-042513-154212 ; https://digitalcommons.wpi.edu/etd-theses/303.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Ji, Wenzhi. “Reconfigurable Fiducial-Integrated Modular Needle Driver For MRI-Guided Percutaneous Interventions.” 2013. Web. 18 Jan 2021.
Vancouver:
Ji W. Reconfigurable Fiducial-Integrated Modular Needle Driver For MRI-Guided Percutaneous Interventions. [Internet] [Thesis]. Worcester Polytechnic Institute; 2013. [cited 2021 Jan 18].
Available from: etd-042513-154212 ; https://digitalcommons.wpi.edu/etd-theses/303.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Ji W. Reconfigurable Fiducial-Integrated Modular Needle Driver For MRI-Guided Percutaneous Interventions. [Thesis]. Worcester Polytechnic Institute; 2013. Available from: etd-042513-154212 ; https://digitalcommons.wpi.edu/etd-theses/303
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Wayne State University
12.
King, Brady.
Optimal Port Placement And Automated Robotic Positioning For Instrumented Laparoscopic Biosensors.
Degree: PhD, Electrical and Computer Engineering, 2011, Wayne State University
URL: https://digitalcommons.wayne.edu/oa_dissertations/214
► OPTIMAL SURGICAL PORT PLACEMENT AND AUTOMATED ROBOTIC POSITIONING FOR RAMAN AND OTHER BIOSENSORS by BRADY KING January 2011 Advisors: Dr. Abhilash Pandya, Dr. Darin…
(more)
▼ OPTIMAL SURGICAL PORT PLACEMENT AND AUTOMATED ROBOTIC POSITIONING FOR RAMAN AND OTHER BIOSENSORS
by
BRADY KING
January 2011
Advisors: Dr. Abhilash Pandya, Dr. Darin Ellis, Dr. Le Yi Wang, and Dr. Greg Auner
Major: Computer Engineering
Degree: Doctor of Philosophy
Medical biosensors can provide new information during minimally invasive and robotic surgical procedures. However, these biosensors have significant physical limitations that make it difficult to find optimal port locations and place them
in vivo. This dissertation explores the application of robotics and virtual/augmented reality to biosensors to enable their optimal use
in vivo.
In the first study, human performance in the task of port placement was evaluated to determine if computer intervention and assistance was needed. Using a virtual surgical environment, we present a number of targets on one or more tissue surfaces. A human factors study was conducted with 20 subjects that analyzed the
subject's placement of a port with the goal of scanning as many targets as possible with a biosensor. The study showed performance to be less than optimal with significant degradation in several specific scenarios.
In the second study, an automated intelligent port placement system for biosensor use was developed. Patient data was displayed in an environment in which a surgeon could indicate areas of interest. The system utilized biosensor physical limitations and provided the best port location from which the biosensor could reach the targets on a collision-free path. The study showed that it is possible to find an optimal port location for proper biosensor data capture.
In the final study, a surgical robot was investigated for potential use in holding and positioning a biosensor
in vivo. A full control suite was developed for an AESOP 1000, enabling the positioning of the biosensor without hand manipulation. It was found that the robot lacks the accuracy needed for proper biosensor utilization. Specific causes for the inaccuracies were identified for analysis and consideration in future robotic platforms.
Overall, the results show that the application of medical robotics and virtual/augmented reality is able to overcome of the significant physical limitations inherent to biosensor design that currently limit their use in
surgery. We conjecture that a complete system, with a more accurate robot, could be used
in vivo. We believe that results taken from the individual studies will result in improvements to pre-operative port placement and robotic design.
Advisors/Committee Members: Abhilash Pandya.
Subjects/Keywords: Image-Guided Surgery; Medical Robotics; Port Placement; Raman Spectroscopy; Sensor Integration; Computer Engineering; Robotics; Surgery
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APA (6th Edition):
King, B. (2011). Optimal Port Placement And Automated Robotic Positioning For Instrumented Laparoscopic Biosensors. (Doctoral Dissertation). Wayne State University. Retrieved from https://digitalcommons.wayne.edu/oa_dissertations/214
Chicago Manual of Style (16th Edition):
King, Brady. “Optimal Port Placement And Automated Robotic Positioning For Instrumented Laparoscopic Biosensors.” 2011. Doctoral Dissertation, Wayne State University. Accessed January 18, 2021.
https://digitalcommons.wayne.edu/oa_dissertations/214.
MLA Handbook (7th Edition):
King, Brady. “Optimal Port Placement And Automated Robotic Positioning For Instrumented Laparoscopic Biosensors.” 2011. Web. 18 Jan 2021.
Vancouver:
King B. Optimal Port Placement And Automated Robotic Positioning For Instrumented Laparoscopic Biosensors. [Internet] [Doctoral dissertation]. Wayne State University; 2011. [cited 2021 Jan 18].
Available from: https://digitalcommons.wayne.edu/oa_dissertations/214.
Council of Science Editors:
King B. Optimal Port Placement And Automated Robotic Positioning For Instrumented Laparoscopic Biosensors. [Doctoral Dissertation]. Wayne State University; 2011. Available from: https://digitalcommons.wayne.edu/oa_dissertations/214
University of Washington
13.
White, Jedediah Keith.
Patient-Specific Guides: Improved Point-Registration Accuracy for Surgical Navigation and Robotic-Assisted Surgery.
Degree: 2017, University of Washington
URL: http://hdl.handle.net/1773/39949
► Image-based surgical navigation offers improved integration of preoperative planning with intraoperative execution and documentation. Registration is a fundamental step in all surgical navigation procedures and…
(more)
▼ Image-based surgical navigation offers improved integration of preoperative planning with intraoperative execution and documentation. Registration is a fundamental step in all surgical navigation procedures and entails the alignment of preoperative
image map with intraoperative physical anatomy. While implanted fiducial markers are the gold standard for registration, they either require an extra procedure or intraoperative imaging that add time and cost to the course of care. It is imperative to find an alternative that reduces the burden on patient, clinician, and the health care system. Paired-point matching using anatomic landmarks and surface mapping have been used as alternatives, but distinct landmarks or surfaces are needed for their effectiveness. A patient-specific point-registration guide was thus developed and evaluated for accuracy and precision in an idealized model. Results were encouraging and further work is recommended.
Advisors/Committee Members: Ching, Randal P. (advisor).
Subjects/Keywords: image-guided surgery; patient-specific guides; rapid prototyping; registration; surgical navigation; Biomedical engineering; Surgery; Bioengineering
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APA (6th Edition):
White, J. K. (2017). Patient-Specific Guides: Improved Point-Registration Accuracy for Surgical Navigation and Robotic-Assisted Surgery. (Thesis). University of Washington. Retrieved from http://hdl.handle.net/1773/39949
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
White, Jedediah Keith. “Patient-Specific Guides: Improved Point-Registration Accuracy for Surgical Navigation and Robotic-Assisted Surgery.” 2017. Thesis, University of Washington. Accessed January 18, 2021.
http://hdl.handle.net/1773/39949.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
White, Jedediah Keith. “Patient-Specific Guides: Improved Point-Registration Accuracy for Surgical Navigation and Robotic-Assisted Surgery.” 2017. Web. 18 Jan 2021.
Vancouver:
White JK. Patient-Specific Guides: Improved Point-Registration Accuracy for Surgical Navigation and Robotic-Assisted Surgery. [Internet] [Thesis]. University of Washington; 2017. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/1773/39949.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
White JK. Patient-Specific Guides: Improved Point-Registration Accuracy for Surgical Navigation and Robotic-Assisted Surgery. [Thesis]. University of Washington; 2017. Available from: http://hdl.handle.net/1773/39949
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Western Ontario
14.
Vassallo, Reid.
Video Processing for the Evaluation of Vascular Dynamics in Neurovascular Interventions.
Degree: 2020, University of Western Ontario
URL: https://ir.lib.uwo.ca/etd/6995
► An arteriovenous malformation (AVM) is an abnormal collection of blood vessels which causes blood to travel from arteries to veins through an abnormal twisted network…
(more)
▼ An arteriovenous malformation (AVM) is an abnormal collection of blood vessels which causes blood to travel from arteries to veins through an abnormal twisted network of vessels. This network has an elevated risk of rupture, which can lead to permanent disability and death if the rupture occurs in the brain. The gold standard treatment for AVM is surgical resection, and it is crucial to know which vessels are bringing blood towards and away from the AVM. Unfortunately, it is almost impossible to know this by looking at the surgical scene. The primary limitations of current methods to address this are requirements for extra hardware and a lack of intraoperative blood flow information.
Here, preliminary results are presented for two video-based methods to provide this important clinical information. Videos from routinely-used surgical microscopes are enhanced and analyzed to determine the identity of vessels of interest and guide AVM resection surgery.
Subjects/Keywords: Cerebrovascular surgery; Video enhancement; Image-guided surgery; Arteriovenous malformation; Surgical guidance; Bioimaging and Biomedical Optics
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APA (6th Edition):
Vassallo, R. (2020). Video Processing for the Evaluation of Vascular Dynamics in Neurovascular Interventions. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/6995
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Vassallo, Reid. “Video Processing for the Evaluation of Vascular Dynamics in Neurovascular Interventions.” 2020. Thesis, University of Western Ontario. Accessed January 18, 2021.
https://ir.lib.uwo.ca/etd/6995.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Vassallo, Reid. “Video Processing for the Evaluation of Vascular Dynamics in Neurovascular Interventions.” 2020. Web. 18 Jan 2021.
Vancouver:
Vassallo R. Video Processing for the Evaluation of Vascular Dynamics in Neurovascular Interventions. [Internet] [Thesis]. University of Western Ontario; 2020. [cited 2021 Jan 18].
Available from: https://ir.lib.uwo.ca/etd/6995.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Vassallo R. Video Processing for the Evaluation of Vascular Dynamics in Neurovascular Interventions. [Thesis]. University of Western Ontario; 2020. Available from: https://ir.lib.uwo.ca/etd/6995
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Toronto
15.
Daly, Michael John.
An Image-Guided Computational Framework for Intraoperative Fluorescence Quantification.
Degree: PhD, 2018, University of Toronto
URL: http://hdl.handle.net/1807/102851
► Fluorescence-guided surgery uses molecular agents that target tumors, lymph nodes, or blood vessels. Optical devices measure fluorescence light emissions from these functional biomarkers to help…
(more)
▼ Fluorescence-guided surgery uses molecular agents that target tumors, lymph nodes, or blood vessels. Optical devices measure fluorescence light emissions from these functional biomarkers to help surgeons differentiate diseased and healthy anatomy. Clinical indications for fluorescence guidance continue to expand, and are being spurred by the rapid development of new agents that improve biological targeting. To capitalize fully on these advances, there is a corresponding need to engineer high-resolution imaging systems that provide objective measurements of fluorescence.
The key innovation in this thesis is the development of a computational framework for image-guided fluorescence quantification. The underlying principle is to directly incorporate spatial localization of patient anatomy and optical devices into multi-stage models of fluorescence light transport. This technique leverages technology for intraoperative cone-beam CT (CBCT) imaging and surgical navigation to account for tissue deformation and surgical excision. A novel calibration algorithm enables real-time compensation for fluorescence variations due to illumination inhomogeneities, tissue topography, and camera response. In endoscopic images of realistic oral cavity phantoms, navigated light transport modeling not only improved fluorescence quantification accuracy at the tissue surface, but also reduced tissue misclassification in a simulated model of surgical decision making (e.g., tumor vs. normal, perfused vs. necrotic) in comparison to an unguided approach. The image-guidance framework was also applied to a finite-element implementation of diffuse fluorescence tomography. Camera and laser tracking enabled adaptive, non-contact acquisition. Sub-surface spatial priors from CBCT imaging improved the depth-resolved spatial resolution and fluorescence quantification accuracy in liquid phantom experiments.
These investigations elucidate the deleterious effects of view-dependent illumination inhomogeneities and depth-dependent diffuse tissue transport on fluorescence quantification accuracy. Moreover, the direct use of 3D data from a CBCT-guided surgical navigation system in computational light transport models improves fluorescence quantification and tissue classification accuracy in pre-clinical experiments. Future clinical translation of these fluorescence-guided surgery techniques is an essential next step to further assess the potential impact on intraoperative decision making and cancer patient care.
2020-11-16 00:00:00
Advisors/Committee Members: Jaffray, David A, Medical Science.
Subjects/Keywords: Biophotonics; Cancer Surgery; Computational Light Transport; Fluorescence Quantification; Image-Guided Surgery; Intraoperative Imaging; 0541
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APA (6th Edition):
Daly, M. J. (2018). An Image-Guided Computational Framework for Intraoperative Fluorescence Quantification. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/102851
Chicago Manual of Style (16th Edition):
Daly, Michael John. “An Image-Guided Computational Framework for Intraoperative Fluorescence Quantification.” 2018. Doctoral Dissertation, University of Toronto. Accessed January 18, 2021.
http://hdl.handle.net/1807/102851.
MLA Handbook (7th Edition):
Daly, Michael John. “An Image-Guided Computational Framework for Intraoperative Fluorescence Quantification.” 2018. Web. 18 Jan 2021.
Vancouver:
Daly MJ. An Image-Guided Computational Framework for Intraoperative Fluorescence Quantification. [Internet] [Doctoral dissertation]. University of Toronto; 2018. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/1807/102851.
Council of Science Editors:
Daly MJ. An Image-Guided Computational Framework for Intraoperative Fluorescence Quantification. [Doctoral Dissertation]. University of Toronto; 2018. Available from: http://hdl.handle.net/1807/102851
University of Melbourne
16.
Dixon, Benjamin J.
Optimising real-time surgical navigation interface design: enhancing spatial awareness while limiting distraction.
Degree: 2017, University of Melbourne
URL: http://hdl.handle.net/11343/123744
► Modern diagnostic imaging techniques allow surgeons to preoperatively scrutinise anatomy and pathology in an ever more precise fashion. Surgical planning may be honed to minimise…
(more)
▼ Modern diagnostic imaging techniques allow surgeons to preoperatively scrutinise anatomy and pathology in an ever more precise fashion. Surgical planning may be honed to minimise access and perform targeted yet thorough procedures.
Image guided surgery systems help integrate this valuable data into the operating theatre to aid spatial awareness during surgery. Advanced navigational displays show promise in providing surgeons with real-time image guidance presented in an intuitive manner during a procedure. In addition to standard 2-dimensional cross-sectional views, options for visual presentation include 3-dimensional virtual views and augmented reality.
Live computer-assisted feedback may include a 3-dimensional visual representation of tool position and critical structure’s with proximity auditory alerts.
Although orientation may be enhanced, additional stimuli inherently demand some attention from the operator. An ideal user interface would provide accurate and accessible navigational data with minimal distraction. This thesis explores, through pre-clinical navigation and dissection trials, ways to provide the potential benefits of surgical precision and efficiency while mitigating distracting cues.
Cadaver dissection trials allowed structured testing of the new technology, which is directly compared to conventional systems.
Real-time surgical navigation systems are shown to enhance spatial awareness while reducing task workload during complex endoscopic skull base surgery. These systems showed particular promise where there was high spatial demand, compromised visual landmarks and proximity to critical structures.
World first surgical studies investigating the attentional cost of advanced navigational displays highlight the potential dangers of this technology. The concept of inattentional blindness is introduced into the surgical literature with experimental evidence of its existence. Augmented reality advanced navigational displays are shown to increase inattentional blindness with a reduced detection of unexpected but salient findings.
The findings serve to caution injudicious adoption of this technology and reinforce the need for pre-clinical human factors testing.
Subjects/Keywords: surgery; surgical navigation; image guided surgery; augmented reality; inattentional blindness; virtual reality; skull base surgery; computer assisted surgery
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APA (6th Edition):
Dixon, B. J. (2017). Optimising real-time surgical navigation interface design: enhancing spatial awareness while limiting distraction. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/123744
Chicago Manual of Style (16th Edition):
Dixon, Benjamin J. “Optimising real-time surgical navigation interface design: enhancing spatial awareness while limiting distraction.” 2017. Doctoral Dissertation, University of Melbourne. Accessed January 18, 2021.
http://hdl.handle.net/11343/123744.
MLA Handbook (7th Edition):
Dixon, Benjamin J. “Optimising real-time surgical navigation interface design: enhancing spatial awareness while limiting distraction.” 2017. Web. 18 Jan 2021.
Vancouver:
Dixon BJ. Optimising real-time surgical navigation interface design: enhancing spatial awareness while limiting distraction. [Internet] [Doctoral dissertation]. University of Melbourne; 2017. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/11343/123744.
Council of Science Editors:
Dixon BJ. Optimising real-time surgical navigation interface design: enhancing spatial awareness while limiting distraction. [Doctoral Dissertation]. University of Melbourne; 2017. Available from: http://hdl.handle.net/11343/123744
Penn State University
17.
Khare, Rahul Shashikant.
Global Registration for Image-guided Bronchoscopy.
Degree: 2012, Penn State University
URL: https://submit-etda.libraries.psu.edu/catalog/15750
► Image guided intervention systems have been found to be very effective in carrying out accurate and skill-independent bronchoscopies. A vital aspect of such systems that…
(more)
▼ Image guided intervention systems have been found to be very effective in carrying out accurate and skill-independent bronchoscopies. A vital aspect of such systems that is essential for success during a live procedure is the registration of the bronchoscope in the multi-detector computed-tomography (MDCT) derived virtual space. This registration of the bronchoscope enables navigational pathplanning to guide the physician to the diagnostic regions of interest (ROIs). When the ROI is reached, which is very often beyond the airway walls, the registration aids in localization for effective biopsy sampling.
During a live bronchoscopy procedure, adverse events such as patient coughing lead to the bronchoscope moving to an unknown location. Such events disrupt bronchoscopy guidance. Manual intervention by an assisting technician often helps in recovering from such a disruption, but this results in extra procedure time and some potential uncertainty in the registered position. Furthermore, at some bifurcations, physicians are forced to carry out bronchoscope maneuvers spanning across several airway generations. Previously proposed local registration-based systems find it difficult to handle these maneuvers. To address these situations, we propose a global registration system for
image-
guided bronchoscopy. This system identifies the bronchoscope position without the need for significant bronchoscope maneuvers or technician intervention. The algorithm involves a fast local registration search over all the branches in a global airway-bifurcation search space, with the weighted normalized sum of squares distance metric used for finding the best match. The algorithm was tested using virtual cases, airway phantoms and also video frames from live patients. The algorithm was implemented in a parallel paradigm and takes less than 2 seconds to execute making it feasible for use in a clinical setting. Experiments also show that the performance of the algorithm can be improved by incorporating multiple frames.
We also proposed a technician-free system-level solution for
image-
guided bronchoscopy with two main features. The first feature is a system-level guidance strategy that incorporates a global registration algorithm to provide the physician with updated navigational and guidance information during bronchoscopy. The system can handle general navigation to a region of interest(ROI), as well as adverse events, and it requires minimal commands so that it can be directly controlled by the physician. The second feature visualizes the global picture of all the bifurcations and their relative orientations in advance and suggests the maneuvers needed by the bronchoscope to approach the ROI. The guidance system was tested during live bronchoscopy for nine patients and was able to guide the physician to the ROIs with a success rate of more than 97%. We also validated the system using airway phantoms and found it to be effective in guidance to ROIs at peripheral lung regions up to airway generation 12.
Advisors/Committee Members: William Evan Higgins, Dissertation Advisor/Co-Advisor, William Evan Higgins, Committee Chair/Co-Chair, Kenneth Jenkins, Committee Member, Vishal Monga, Committee Member, Robert Collins, Committee Member.
Subjects/Keywords: global registration; image-guided surgery; virtual endoscopy; virtual bronchoscopy; 3D imaging; image registration
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Manager
APA (6th Edition):
Khare, R. S. (2012). Global Registration for Image-guided Bronchoscopy. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/15750
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Khare, Rahul Shashikant. “Global Registration for Image-guided Bronchoscopy.” 2012. Thesis, Penn State University. Accessed January 18, 2021.
https://submit-etda.libraries.psu.edu/catalog/15750.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Khare, Rahul Shashikant. “Global Registration for Image-guided Bronchoscopy.” 2012. Web. 18 Jan 2021.
Vancouver:
Khare RS. Global Registration for Image-guided Bronchoscopy. [Internet] [Thesis]. Penn State University; 2012. [cited 2021 Jan 18].
Available from: https://submit-etda.libraries.psu.edu/catalog/15750.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Khare RS. Global Registration for Image-guided Bronchoscopy. [Thesis]. Penn State University; 2012. Available from: https://submit-etda.libraries.psu.edu/catalog/15750
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Vanderbilt University
18.
Kratchman, Louis Beryl.
Image-Guided Targeting and Control of Implantable Electrodes.
Degree: PhD, Mechanical Engineering, 2015, Vanderbilt University
URL: http://hdl.handle.net/1803/11785
► Implantable electrodes are used to diagnose and treat a growing list of conditions, including deafness, chronic pain, and neurodegenerative disorders. This dissertation introduces robotic methods…
(more)
▼ Implantable electrodes are used to diagnose and treat a growing list of conditions, including deafness, chronic pain, and neurodegenerative disorders. This dissertation introduces robotic methods to make electrode implantation less invasive, safer, and easier for clinicians to perform. We focus on implantation through a narrow hole under
image guidance, and contribute methods to both guide instruments along a straight insertion path and to steer electrodes that are inserted through such a hole.
We present the first bone-attached robot to accurately guide instruments to the cochlea. This system removes the need to fabricate a stereotactic guide in the operating room and reduces dependence on a surgeon's skill. Results from a phantom targeting experiment show this system to be sufficiently accurate for cochlear implantation
surgery. Manually adjusted stereotactic frames are used to implant deep brain stimulation (DBS) electrodes, but encumber the patient and are prone to operator errors. Smaller targeting devices are available for DBS
surgery, but require offsite manufacturing or expensive
image guidance systems. We introduce robotically adjusted, disposable microstereotactic frames that are rapidly adjusted, locked, and then transferred to a patient in a single visit. A phantom validation experiment shows that the targeting error of a robotically adjusted frame was below the clinically accepted threshold.
Sensitive tissues can be damaged by the force of electrode implantation. Robotic insertion devices have the potential to detect and react to excessive insertion forces, but the relationship between forces and trauma is poorly understood. Presently, we rely on surgeons to judge when forces are too large, but the ability of surgeons to sense small forces when implanting electrodes has not been studied. We introduce a method to measure intraocochlear puncture forces and report the first force measurements obtained from fresh cadaveric specimens. To put these forces into a clinical perspective, we present a protocol to measure tactile thresholds in a model of CI
surgery, and present the first experimental characterization of surgeons' tactile force thresholds.
An electrode can be actively steered to reduce trauma and avoid obstacles. We present the first method to guide a magnet-tipped electrode along arbitrary three-dimensional trajectories using a compact, robot-manipulated magnet located external to the patient. We model rod deflections by combining Kirchhoff rod theory with permanent magnet models, and compute trajectories using a resolved-rate approach. Experiments demonstrate accurate execution of three-dimensional tip trajectories in an open-loop configuration and obstacle avoidance.
This dissertation provides a complementary set of methods for improving electrode implantation. These methods could benefit both patients and clinicians who perform minimally invasive procedures.
Advisors/Committee Members: J. Michael Fitzpatrick (committee member), Pietro Valdastri (committee member), Nabil Simaan (committee member), Robert F. Labadie (committee member), Robert J. Webster III (Committee Chair).
Subjects/Keywords: deep brain stimulation surgery; magnetic manipulation; magnetic guidance.; image-guided surgery; Stereotactic devices; cochlear implantation surgery
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APA (6th Edition):
Kratchman, L. B. (2015). Image-Guided Targeting and Control of Implantable Electrodes. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/11785
Chicago Manual of Style (16th Edition):
Kratchman, Louis Beryl. “Image-Guided Targeting and Control of Implantable Electrodes.” 2015. Doctoral Dissertation, Vanderbilt University. Accessed January 18, 2021.
http://hdl.handle.net/1803/11785.
MLA Handbook (7th Edition):
Kratchman, Louis Beryl. “Image-Guided Targeting and Control of Implantable Electrodes.” 2015. Web. 18 Jan 2021.
Vancouver:
Kratchman LB. Image-Guided Targeting and Control of Implantable Electrodes. [Internet] [Doctoral dissertation]. Vanderbilt University; 2015. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/1803/11785.
Council of Science Editors:
Kratchman LB. Image-Guided Targeting and Control of Implantable Electrodes. [Doctoral Dissertation]. Vanderbilt University; 2015. Available from: http://hdl.handle.net/1803/11785
Vanderbilt University
19.
Conley, Rebekah Helene.
A Comprehensive Framework for Image Guided Breast Surgery.
Degree: MS, Biomedical Engineering, 2015, Vanderbilt University
URL: http://hdl.handle.net/1803/10894
► Unfortunately, the current re-excision rates for breast conserving surgeries due to positive margins average 20-40%. The high re-excision rates arise from difficulty in localizing tumor…
(more)
▼ Unfortunately, the current re-excision rates for breast conserving surgeries due to positive margins average 20-40%. The high re-excision rates arise from difficulty in localizing tumor boundaries intraoperatively and lack of real time information on the presence of residual disease. The work presented here introduces the use of supine magnetic resonance (MR) images, digitization technology, and biomechanical models to investigate the capability of using an
image guidance system to localize tumors intraoperatively. Two studies are presented in which preoperative supine MR images were registered to a mock intraoperative setup. In the mock intraoperative setup, a laser range scanner was used to digitize the breast surface and tracked ultrasound was used to digitize the chest wall and tumor. In the first study, a rigid registration was performed and validated using subsurface error metrics between the registered preoperative tumor and the intraoperative tumor as identified by tracked ultrasound. In the second study, a novel nonrigid correction technique was employed to correct for deformations occurring between the preoperative and intraoperative states. Tumor localizations by tracked ultrasound were again used to evaluate the fidelity of aligning preoperative MR tumor contours to physical patient space. Using our prototype
image guided surgery platform, we were able to align intraoperative data with preoperative patient specific models with clinically relevant accuracy.
Advisors/Committee Members: Robert L. Galloway (committee member), Michael I. Miga (Committee Chair).
Subjects/Keywords: nonrigid registration; tracked ultrasound; biomechanical models; image guided surgery; lumpectomy; breast conservation therapy
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Manager
APA (6th Edition):
Conley, R. H. (2015). A Comprehensive Framework for Image Guided Breast Surgery. (Thesis). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/10894
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Conley, Rebekah Helene. “A Comprehensive Framework for Image Guided Breast Surgery.” 2015. Thesis, Vanderbilt University. Accessed January 18, 2021.
http://hdl.handle.net/1803/10894.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Conley, Rebekah Helene. “A Comprehensive Framework for Image Guided Breast Surgery.” 2015. Web. 18 Jan 2021.
Vancouver:
Conley RH. A Comprehensive Framework for Image Guided Breast Surgery. [Internet] [Thesis]. Vanderbilt University; 2015. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/1803/10894.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Conley RH. A Comprehensive Framework for Image Guided Breast Surgery. [Thesis]. Vanderbilt University; 2015. Available from: http://hdl.handle.net/1803/10894
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Vanderbilt University
20.
Dillon, Neal Patrick.
Analysis, Design, and Modeling of Image-Guided Robotic Systems for Otologic Surgery.
Degree: PhD, Mechanical Engineering, 2017, Vanderbilt University
URL: http://hdl.handle.net/1803/10477
► Otology and neurotology are surgical specialties focusing on the treatment of ear diseases. A key component of many otologic and neurotologic surgical procedures is the…
(more)
▼ Otology and neurotology are surgical specialties focusing on the treatment of ear diseases. A key component of many otologic and neurotologic surgical procedures is the
removal of a portion of the skull behind the ear to gain access to subsurface anatomy.
This process, called a mastoidectomy, is performed manually with a high speed surgical drill. Many vital structures, including nerves and blood vessels, are embedded
within the temporal bone near the region of bone that must be removed, which makes
the procedure difficult, time consuming, and in some cases, overly invasive.
Image-
guided and robotic systems have the potential to improve otologic procedures using medical imaging to guide their interventions, enabling patient-specific treatments that reduce invasiveness and save valuable operating room time. However, since damage to the complex vital structures within the surgical field could result in severe consequences to the patient, any
image-
guided or robotic surgical system must be extremely safe and accurate. These requirements, along with the small surgical workspace and difficulty integrating systems into the current clinical workflow, have limited the adoption of such systems in otologic
surgery to date.
This dissertation presents the design, experimentation, and analyses of
image-
guided, robotic systems under development for otologic
surgery in an effort to bring these systems closer to clinical realization. The specific goals of the work are to better understand the technical requirements of various otologic surgical procedures, to improve the safety and efficiency of
image-
guided and robotic
surgery by incorporating system modeling and medical
image data into the surgical planning process, and to show feasibility and provide insights into practical issues through experimentation.
Two
image-
guided otologic procedures are explored in this work: (1) robotic mastoidectomy and (2) minimally invasive cochlear implantation. The technical requirements of robotic mastoidectomy are first explored to determine the necessary robot workspace and the required milling forces. Using these design requirements, a bone-attached robotic system is developed and tested in temporal bone specimens and fresh human cadaver heads. Next, planning algorithms to improve the safety and efficiency of robotic mastoidectomy are described. A method for building patient-specific safety margins around vital anatomy based on probabilistic error models of the robotic system, required safety rates, and simulations of the
surgery is provided. A second planning algorithm is presented, which improves robot trajectory generation for milling porous bone in close proximity to vital anatomy by using CT
image-based force modeling to optimize tool orientation and velocity.
The focus then shifts to minimally invasive,
image-
guided cochlear implantation. Two key safety issues are investigated: the positional accuracy of drilling a narrow tunnel towards the cochlea for electrode insertion and the heat rise near vital nerves during drilling. A method…
Advisors/Committee Members: Thomas J. Withrow (committee member), Robert F. Labadie (committee member), Nabil Simaan (committee member), Michael I. Miga (committee member), Robert J. Webster III (Committee Chair).
Subjects/Keywords: Image-guided surgery; medical robotics; cochlear implantation; mastoidectomy; robotic bone milling; robot trajectory planning
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APA (6th Edition):
Dillon, N. P. (2017). Analysis, Design, and Modeling of Image-Guided Robotic Systems for Otologic Surgery. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/10477
Chicago Manual of Style (16th Edition):
Dillon, Neal Patrick. “Analysis, Design, and Modeling of Image-Guided Robotic Systems for Otologic Surgery.” 2017. Doctoral Dissertation, Vanderbilt University. Accessed January 18, 2021.
http://hdl.handle.net/1803/10477.
MLA Handbook (7th Edition):
Dillon, Neal Patrick. “Analysis, Design, and Modeling of Image-Guided Robotic Systems for Otologic Surgery.” 2017. Web. 18 Jan 2021.
Vancouver:
Dillon NP. Analysis, Design, and Modeling of Image-Guided Robotic Systems for Otologic Surgery. [Internet] [Doctoral dissertation]. Vanderbilt University; 2017. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/1803/10477.
Council of Science Editors:
Dillon NP. Analysis, Design, and Modeling of Image-Guided Robotic Systems for Otologic Surgery. [Doctoral Dissertation]. Vanderbilt University; 2017. Available from: http://hdl.handle.net/1803/10477
Vanderbilt University
21.
Chen, Ishita.
Evaluation of atlas-based brain shift model for improved adaptation to intraoperative neurosurgical conditions.
Degree: PhD, Biomedical Engineering, 2012, Vanderbilt University
URL: http://hdl.handle.net/1803/12200
► Image guidance utilizes a rigid registration between the preoperative images and physical space of the operating room and it is now the standard of care…
(more)
▼ Image guidance utilizes a rigid registration between the preoperative images and physical space of the operating room and it is now the standard of care in neurosurgical procedures. The fidelity of the
image guidance system is known to be compromised by the extensively studied phenomenon of brain shift. A considerable body of work in literature has focused on solving this problem either through intraoperative imaging or by updating preoperative images with mathematical models. The factors that affect the magnitude and the direction of tissue deformation cannot be predicted to exact precision before the procedure and are often difficult to measure during the procedure. In previous literature, to account for this uncertainty, a statistical atlas-based method was used to capture the range of possible solutions. This work was validated using postoperative magnetic resonance (MR) data. Postoperative MR images are typically acquired after a lapse of 24 hours of
surgery, during which period a shift recovery is known to occur. As a result, the postoperative measurements are typically smaller than what would be observed intraoperatively. Moreover the surgical environment is quite dynamic due to active tissue resection and retraction, which affect the observed displacements in the region of the craniotomy. The goal of this work was to systematically study the differences between the pre- and post-operative MR deformation and preoperative MR and intraoperative laser range scan deformation and devise strategies to better adapt the atlas-based model for intraoperative conditions. Strategies for improving the subsurface accuracy by accounting for the dural septa were studied. In order to make the atlas-based method feasible for intraoperative implementation, methods for automation of brain and dural septa segmentation were developed. Sensitivity analysis was performed to determine the impact of atlas resolution on accuracy. Lastly, preliminary studies for integration of intraoperative forces of retraction and resection into the atlas-based model were conducted. The results of these studies provide important conclusions to advance the goal of implementation of an efficient and cost-effective brain shift correction strategy for the neurosurgical
image guidance.
Advisors/Committee Members: Reid Thompson (committee member), Robert Galloway, Jr. (committee member), Benoit Dawant (committee member), Robert Webster, III (committee member), Michael Miga (Committee Chair).
Subjects/Keywords: image guided surgery; inverse model; finite element; computational model; brain shift; neurosurgery
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Manager
APA (6th Edition):
Chen, I. (2012). Evaluation of atlas-based brain shift model for improved adaptation to intraoperative neurosurgical conditions. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/12200
Chicago Manual of Style (16th Edition):
Chen, Ishita. “Evaluation of atlas-based brain shift model for improved adaptation to intraoperative neurosurgical conditions.” 2012. Doctoral Dissertation, Vanderbilt University. Accessed January 18, 2021.
http://hdl.handle.net/1803/12200.
MLA Handbook (7th Edition):
Chen, Ishita. “Evaluation of atlas-based brain shift model for improved adaptation to intraoperative neurosurgical conditions.” 2012. Web. 18 Jan 2021.
Vancouver:
Chen I. Evaluation of atlas-based brain shift model for improved adaptation to intraoperative neurosurgical conditions. [Internet] [Doctoral dissertation]. Vanderbilt University; 2012. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/1803/12200.
Council of Science Editors:
Chen I. Evaluation of atlas-based brain shift model for improved adaptation to intraoperative neurosurgical conditions. [Doctoral Dissertation]. Vanderbilt University; 2012. Available from: http://hdl.handle.net/1803/12200
Vanderbilt University
22.
Hartmann, Steven L.
Intraoperative identification and display of cortical brain function.
Degree: PhD, Biomedical Engineering, 2002, Vanderbilt University
URL: http://hdl.handle.net/1803/10975
► The objective of this research was to design and develop a system capable of displaying cortical brain function during image-guided neurosurgery. Brain function was determined…
(more)
▼ The objective of this research was to design and develop a system capable of displaying cortical brain function during
image-
guided neurosurgery. Brain function was determined using a cortical stimulator, classified according to function type, and displayed along with pre-operative tomographic and rendered images of the brain. In addition to displaying brain function acquired from the patient undergoing
surgery, a probabilistic map of functional information acquired from a database or previous patients may also be displayed. This information is stored in an atlas coordinate system and can be mapped to the patient's coordinate system for display during
surgery.
The entire system was tested and evaluated during three human neurosurgery procedures. Functional information corresponding to speech, motor, and sensory regions was identified and displayed during
surgery. This data was then mapped to a common reference database using a non-linear registration algorithm to evaluate the feasibility of using this system to create a functional atlas of the human brain.
Advisors/Committee Members: Peter E. Konrad (committee member), J. Michael Fitzpatrick (committee member), Michael I. Miga (committee member), Robert L. Galloway (Committee Chair), Benoit M. Dawant (Committee Chair).
Subjects/Keywords: registration; image-guided surgery; brain function
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APA (6th Edition):
Hartmann, S. L. (2002). Intraoperative identification and display of cortical brain function. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/10975
Chicago Manual of Style (16th Edition):
Hartmann, Steven L. “Intraoperative identification and display of cortical brain function.” 2002. Doctoral Dissertation, Vanderbilt University. Accessed January 18, 2021.
http://hdl.handle.net/1803/10975.
MLA Handbook (7th Edition):
Hartmann, Steven L. “Intraoperative identification and display of cortical brain function.” 2002. Web. 18 Jan 2021.
Vancouver:
Hartmann SL. Intraoperative identification and display of cortical brain function. [Internet] [Doctoral dissertation]. Vanderbilt University; 2002. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/1803/10975.
Council of Science Editors:
Hartmann SL. Intraoperative identification and display of cortical brain function. [Doctoral Dissertation]. Vanderbilt University; 2002. Available from: http://hdl.handle.net/1803/10975
Queens University
23.
Chen, Kuiran.
An Automated Ultrasound Calibration Framework Incorporating Elevation Beamwidth for Tracked Ultrasound Interventions
.
Degree: Computing, 2012, Queens University
URL: http://hdl.handle.net/1974/7614
► Image-guided surgeries employ advanced imaging and computing technologies to assist the surgeon when direct visualization is inadequate or unavailable. As modern surgeries continue to move…
(more)
▼ Image-guided surgeries employ advanced imaging and computing technologies to assist the surgeon when direct visualization is inadequate or unavailable. As modern surgeries continue to move toward minimally invasive procedures, tracked ultrasound (US), an emerging technology that uniquely combines US imaging and position tracking, has been increasingly used for intraoperative guidance in surgical interventions.
The intrinsic accuracy of a tracked US system is primarily determined by a unique procedure called ``probe calibration", where a spatial registration between the coordinate systems of the transducer (provided by a tracking device affixed to the probe) and the US image plane must be established prior to imaging. Inaccurate system calibration causes misalignments between the US image and the surgical end-effectors, which may directly contribute to treatment failure. The probe calibration quality is further reduced by the "elevation beamwidth" or "slice thickness", a unique feature of the ultrasound beam pattern that gives rise to localization errors and imaging uncertainties.
In this thesis, we aim to provide an automated, pure-computation-based, intraoperative calibration solution that also incorporates the slice thickness to improve the calibration accuracy, precision and reliability. The following contributions have been made during the course of this research. First, we have designed and developed an automated, freehand US calibration system with instant feedback on its calibration accuracy. The system was able to consistently achieve submillimeter accuracy with real-time performance.
Furthermore, we have developed a novel beamwidth-weighted calibration framework (USB-FW) that incorporates US slice thickness to improve the estimation of calibration parameters. The new framework provides an effective means of quality control for calibration results. Extensive phantom validation demonstrated that USB-FW introduces statistically significant reduction (p = 0.001) in the calibration errors and produces calibration outcomes that are less variable than a conventional, non-beamwidth-weighted calibration.
Finally, we were the first to introduce an automated, intraoperative Transrectal Ultrasound (TRUS) calibration technology for needle guidance in prostate brachytherapy. Our tests with multiple commercial TRUS scanners and brachytherapy stepper systems demonstrated that the proposed method is practical in use and can achieve high calibration accuracy, precision and robustness.
Subjects/Keywords: ultrasound elevation beamwidth
;
ultrasound slice thickness
;
probe calibration
;
image-guided surgery
;
tracked ultrasound
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Manager
APA (6th Edition):
Chen, K. (2012). An Automated Ultrasound Calibration Framework Incorporating Elevation Beamwidth for Tracked Ultrasound Interventions
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/7614
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Chen, Kuiran. “An Automated Ultrasound Calibration Framework Incorporating Elevation Beamwidth for Tracked Ultrasound Interventions
.” 2012. Thesis, Queens University. Accessed January 18, 2021.
http://hdl.handle.net/1974/7614.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Chen, Kuiran. “An Automated Ultrasound Calibration Framework Incorporating Elevation Beamwidth for Tracked Ultrasound Interventions
.” 2012. Web. 18 Jan 2021.
Vancouver:
Chen K. An Automated Ultrasound Calibration Framework Incorporating Elevation Beamwidth for Tracked Ultrasound Interventions
. [Internet] [Thesis]. Queens University; 2012. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/1974/7614.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Chen K. An Automated Ultrasound Calibration Framework Incorporating Elevation Beamwidth for Tracked Ultrasound Interventions
. [Thesis]. Queens University; 2012. Available from: http://hdl.handle.net/1974/7614
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
24.
Certo, Francesco.
Technological innovations in multimodal management of glioblastoma: from nano-drugs to imaging guided surgery and supra-maximal resection.
Degree: 2018, Università degli Studi di Catania
URL: http://hdl.handle.net/10761/4189
► Primary brain tumors are a major cause of morbidity and mortality in the United States. Approximately one-third of tumors are malignant and the remaining are…
(more)
▼ Primary brain tumors are a major cause of morbidity and mortality in the United States. Approximately one-third of tumors are malignant and the remaining are benign or borderline malignant. High-grade glioma, in particular glioblastoma, management is a great challenge for both neurosurgeons and patients. More than 45% of CNS primary malignant tumours are glioblastoma and their 5 year-survival is only 5% on average. Although biomolecular differences between glioblastoma IDH-WT and IDH-mutant might account for different outcomes, treatment strategies, including surgical EOR, chemiotherapy and radiotherapy, are currently considered important factors associated with PFS and OS.
objective of this thesis is the definition of a neuro-oncological protocol, to be reserved for patients with glioblastoma, which can establish a therapeutic path that starts with a safe and effective surgery and continues with a pharmacological treatment that may lead to the limitations of current antitumor therapy schemes.
Two main research lines have been conducted, with these purposes: the first one, essentially clinical, has been analysed in two consecutive studies, first retrospectively, then prospectively, the results of the application of an intraoperative imaging protocol that foresees the use of Advanced neuronavigation, intraoperative fluorescence and intraoperative CT. The second line of research was instead based on the attempt to obtain a pharmacological preparation which provided for the combination of temozolomide with nano-vectors, able to increase its antiblastic efficacy and to increase its chances of delivery at the intracranial level.
Subjects/Keywords: Area 06 - Scienze mediche; Glioblastoma, image-guided surgery, drug-delivery, nose-to brain pathway.
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APA (6th Edition):
Certo, F. (2018). Technological innovations in multimodal management of glioblastoma: from nano-drugs to imaging guided surgery and supra-maximal resection. (Thesis). Università degli Studi di Catania. Retrieved from http://hdl.handle.net/10761/4189
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Certo, Francesco. “Technological innovations in multimodal management of glioblastoma: from nano-drugs to imaging guided surgery and supra-maximal resection.” 2018. Thesis, Università degli Studi di Catania. Accessed January 18, 2021.
http://hdl.handle.net/10761/4189.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Certo, Francesco. “Technological innovations in multimodal management of glioblastoma: from nano-drugs to imaging guided surgery and supra-maximal resection.” 2018. Web. 18 Jan 2021.
Vancouver:
Certo F. Technological innovations in multimodal management of glioblastoma: from nano-drugs to imaging guided surgery and supra-maximal resection. [Internet] [Thesis]. Università degli Studi di Catania; 2018. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/10761/4189.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Certo F. Technological innovations in multimodal management of glioblastoma: from nano-drugs to imaging guided surgery and supra-maximal resection. [Thesis]. Università degli Studi di Catania; 2018. Available from: http://hdl.handle.net/10761/4189
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Georgia State University
25.
Levitz, Andrew R.
Synthesis of Various Classes of Cyanine Fluorophores and Their Application In In Vivo Tissue Imaging.
Degree: PhD, Chemistry, 2017, Georgia State University
URL: https://scholarworks.gsu.edu/chemistry_diss/130
► A novel series of near-infrared fluorescent contrast agents was developed and characterized. Their physicochemical and optical properties were measured. By altering functional groups of…
(more)
▼ A novel series of near-infrared fluorescent contrast agents was developed and characterized. Their physicochemical and optical properties were measured. By altering functional groups of cyanine fluorophores, the selective targeting of endocrine glands, exocrine glands, cartilage and bone using NIR fluorescence to visualize the targeted tissue has been reported. These agents have high specificity for tissue targeting inherent to the chemical structure of the fluorophore. After a single low-dose intravenous injection these agents have high specificity for tissue targeting inherent to the chemical structure of the fluorophore. The results lay the foundation for future improvements in optical imaging in endocrine
surgery, tissue engineering, joint
surgery, and cartilage-specific drug development.
Advisors/Committee Members: Dr. Maged Henary, Dr. Suazette Mooring, Dr. Donald Hamelberg.
Subjects/Keywords: Fluorophores; Imaging agents; NIR fluorescence; Targeted dyes; Cell tracking; Image-guided surgery
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Manager
APA (6th Edition):
Levitz, A. R. (2017). Synthesis of Various Classes of Cyanine Fluorophores and Their Application In In Vivo Tissue Imaging. (Doctoral Dissertation). Georgia State University. Retrieved from https://scholarworks.gsu.edu/chemistry_diss/130
Chicago Manual of Style (16th Edition):
Levitz, Andrew R. “Synthesis of Various Classes of Cyanine Fluorophores and Their Application In In Vivo Tissue Imaging.” 2017. Doctoral Dissertation, Georgia State University. Accessed January 18, 2021.
https://scholarworks.gsu.edu/chemistry_diss/130.
MLA Handbook (7th Edition):
Levitz, Andrew R. “Synthesis of Various Classes of Cyanine Fluorophores and Their Application In In Vivo Tissue Imaging.” 2017. Web. 18 Jan 2021.
Vancouver:
Levitz AR. Synthesis of Various Classes of Cyanine Fluorophores and Their Application In In Vivo Tissue Imaging. [Internet] [Doctoral dissertation]. Georgia State University; 2017. [cited 2021 Jan 18].
Available from: https://scholarworks.gsu.edu/chemistry_diss/130.
Council of Science Editors:
Levitz AR. Synthesis of Various Classes of Cyanine Fluorophores and Their Application In In Vivo Tissue Imaging. [Doctoral Dissertation]. Georgia State University; 2017. Available from: https://scholarworks.gsu.edu/chemistry_diss/130
Leiden University
26.
Tummers, Q.R.J.G.
Fluorescence-guided cancer surgery using clinical available and innovative tumor-specific contrast agents.
Degree: 2017, Leiden University
URL: http://hdl.handle.net/1887/53235
► Intraoperative NIRF imaging using ICG and MB was explored in multiple important indications in cancersurgery. Imaging using ICG resulted in accurate tumor imaging of liver…
(more)
▼ Intraoperative NIRF imaging using ICG and MB was explored
in multiple important indications in cancersurgery. Imaging using ICG
resulted in accurate tumor imaging of liver metastases and SLN detection in
gastriccancer, with high TBRs and prolonged fluorescent signal. For these
indications, our data suggests that fluorescence imaging should be
implemented in the clinic. MB allowed successful imaging of parathyroid
adenomas, neuro-endocrine tumors and breast cancer lesions, but accuracy and
imaging characteristics can be improved by the introduction of more
tumor-specifc contrastagents. However, in the meantime MB can be used for
intraoperative guidance.
Intraoperative imaging of ovarian cancer using the FRα specific EC17 and
OTL38 showed highly specific and accurate tumor imaging with a high TBR and
prolonged fluorescent signal in malignant lesions. Administration of these
low molecular weight contrast agents resulted in rapid accumulation in tumor
tissue and fast clearance from the rest of the body. Moreover, with the NIR
fluorescent contrast agent OTL38 almost no background signal or auto
uorescence was seen. Clinical translation using both healthy subjects and
patients allowed a rapid determination of the optimal dose, formulation, and
time-window for intraoperative imaging, facilitating fast clinical
introduction of newly developed contrast agents in clinical trials
Advisors/Committee Members: Supervisor: Velde C.J.H. van de Co-Supervisor: Vahrmeijer A.L..
Subjects/Keywords: Fluorescence-guided surgery; Image-guided surgery; Cancer surgery; Indocyanine green; Methylene blue; Fluorescence-guided surgery; Image-guided surgery; Cancer surgery; Indocyanine green; Methylene blue
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APA (6th Edition):
Tummers, Q. R. J. G. (2017). Fluorescence-guided cancer surgery using clinical available and innovative tumor-specific contrast agents. (Doctoral Dissertation). Leiden University. Retrieved from http://hdl.handle.net/1887/53235
Chicago Manual of Style (16th Edition):
Tummers, Q R J G. “Fluorescence-guided cancer surgery using clinical available and innovative tumor-specific contrast agents.” 2017. Doctoral Dissertation, Leiden University. Accessed January 18, 2021.
http://hdl.handle.net/1887/53235.
MLA Handbook (7th Edition):
Tummers, Q R J G. “Fluorescence-guided cancer surgery using clinical available and innovative tumor-specific contrast agents.” 2017. Web. 18 Jan 2021.
Vancouver:
Tummers QRJG. Fluorescence-guided cancer surgery using clinical available and innovative tumor-specific contrast agents. [Internet] [Doctoral dissertation]. Leiden University; 2017. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/1887/53235.
Council of Science Editors:
Tummers QRJG. Fluorescence-guided cancer surgery using clinical available and innovative tumor-specific contrast agents. [Doctoral Dissertation]. Leiden University; 2017. Available from: http://hdl.handle.net/1887/53235
Queens University
27.
Anand, Manjunath.
Design And Development of Mobile Image Overlay System For Image-Guided Interventions
.
Degree: Mechanical and Materials Engineering, 2014, Queens University
URL: http://hdl.handle.net/1974/12255
► Numerous studies have demonstrated the potential efficacy of percutaneous image-guided interventions over open surgical interventions. The conventional image-guided procedures are limited by the freehand technique,…
(more)
▼ Numerous studies have demonstrated the potential efficacy of percutaneous image-guided interventions over open surgical interventions. The conventional image-guided procedures are limited by the freehand technique, requiring mental 3D registration and hand-eye coordination for needle placement. The outcomes of these procedures are associated with longer duration and increased patient discomfort with high radiation exposure. Previously, a static image overlay system was proposed for aiding needle interventions. Certain drawbacks associated with the static system limited the clinical translation.
To overcome the ergonomic issues and longer calibration duration associated with static system, an adjustable image overlay system was proposed. The system consisted of monitor and semi-transparent mirror, attached together to an articulated mobile arm. The 90-degree mirror-monitor configuration was proposed to improve the physician access around the patient. MicronTracker was integrated for dynamic tracking of the patient and device. A novel method for auto-direct calibration of the virtual image overlay plane was proposed. Due to large mechanical structure, the precise movement was limited and consumed useful space in the procedure room. A mobile image overlay system with reduced system weight and smaller dimensions was proposed to eliminate the need for mechanical structure. A tablet computer and beamsplitter were used as the display device and mirror respectively. An image overlay visualization module of the 3D Slicer was developed to project the correct image slice upon the tablet device.
The system weight was reduced to 1 kg and the image overlay plane tracking precision (0.11mm STD=0.05) was similar to the printed physical markers. The auto-calibration of the image overlay plane can be done in two simple steps, away from the patient table and without additional phantom. Based on the successful pre-clinical testing of the previous static system, the mobile image overlay system with reduced weight, increased tracking precision and easier maneuverability, can be possibly hand-held by the physician to explore the image volume over the patient and be used for a wide range of procedures. The mobile image overlay system shall be classified as Class II device as per FDA regulations, do not require extensive verification and validation efforts and further improves the commercialization opportunities.
Subjects/Keywords: Percutaneous Surgery
;
Mobile Image Overlay System
;
Computer Assisted Surgery
;
Minimally Invasive Surgery
;
X-ray Vision
;
Image-Guided Needle Interventions
;
Biopsies
;
Image overlay
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APA (6th Edition):
Anand, M. (2014). Design And Development of Mobile Image Overlay System For Image-Guided Interventions
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/12255
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Anand, Manjunath. “Design And Development of Mobile Image Overlay System For Image-Guided Interventions
.” 2014. Thesis, Queens University. Accessed January 18, 2021.
http://hdl.handle.net/1974/12255.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Anand, Manjunath. “Design And Development of Mobile Image Overlay System For Image-Guided Interventions
.” 2014. Web. 18 Jan 2021.
Vancouver:
Anand M. Design And Development of Mobile Image Overlay System For Image-Guided Interventions
. [Internet] [Thesis]. Queens University; 2014. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/1974/12255.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Anand M. Design And Development of Mobile Image Overlay System For Image-Guided Interventions
. [Thesis]. Queens University; 2014. Available from: http://hdl.handle.net/1974/12255
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
28.
Dorval, Paul.
Miniaturisation des technologies d'imagerie de fluorescence pour assister la chirurgie mini-invasive : The miniaturization of fluorescence image guided technologies to assist minimally invasive surgery.
Degree: Docteur es, Signal, image, automatique et robotique (SIAR), 2015, Université de Strasbourg
URL: http://www.theses.fr/2015STRAD005
► L’imagerie de fluorescence est une technique d’imagerie médicale permettant de visualiser l’émission d’un traceur, ou fluorophore, à l’aide d’une excitation de type Laser ou LED.…
(more)
▼ L’imagerie de fluorescence est une technique d’imagerie médicale permettant de visualiser l’émission d’un traceur, ou fluorophore, à l’aide d’une excitation de type Laser ou LED. Les domaines d’application de la technologie sont la chirurgie oncologique, la chirurgie reconstructive ou encore la chirurgie cardiaque. Bien que les besoins en chirurgie ouverte soient importants, l’évolution des pratiques tend à démocratiser la chirurgie dite minimalement invasive. La chirurgie endoscopique va dans ce sens, le but étant de limiter les traumatismes opératoires rencontrés en chirurgie ouverte. Parmi les avantages de cette techniques on note une diminution des saignements et de la douleur, ou encore une réduction de la durée d’hospitalisation.Lors d’une intervention de type chirurgie ouverte, le praticien peur se contenter de la seuls information de fluorescence fournie par le système d’imagerie. Cependant, tout l’enjeu de l’imagerie de fluorescence pour la chirurgie mini-invasive est de venir greffer ne information relative au fluorophore sur une image couleur de très bonne qualité, essentielle au chirurgien. Pour une première évaluation, un système deux caméras a été réalisé. Un capteur est dédié à l’acquisition de l’image couleur et un autre à l’information de fluorescence. Cependant, notamment pour conserver pour conserver un système compact et proposer la meilleure ergonomie possible au chirurgien, l’endoscope final ne devra comporter qu’un seul imageur. Le principe de base est d’utiliser des impulsions de lumière d’excitation et de lumière blanche afin de séquentiellement acquérir les données de fluorescence et les images couleur. Il convient ensuite de traiter les informations recueillies pour reconstruire l’image désirée en temps réel.
Fluorescence image-guided surgery is a medical imaging modality which allows the surgeon to visualize a fluorescent probe previously injected to the patient. The probe could be specific or not and the technology is useful in a wide range of application from oncologic procedures to reconstructive surgeries or cardiac procedures. Despite the important needs of this technology in open-procedures, the surgery in general is more and more minimally invasive. The goal of mini-invasive surgery is to limit patient's per and post operation trauma. The advantages of the technique are a decrease of bleeding and pain and a decreasing hospitalization time.During an open surgery, the B&W fluorescence information given by the fluorescence image-guided surgery system is enough for the surgeon. For mini-invasive procedures, the in-game is to overlay the fluorescence information to high quality color image, compulsory for the surgeon to perform his procedure. As a first evaluation, a 2-sensors system has been rapidly developed. One sensor is dedicated to the acquisition of the color image and the other to the fluorescence information. In order to make the system more compact and improve the quality of the color image furnished to the surgeon, the final system should be composed of only one sensor. To…
Advisors/Committee Members: Poulet, Patrick (thesis director).
Subjects/Keywords: Imagerie médicale; Imagerie de fluorescence peropératoire; Chirurgie mini-invasive; Medical imaging; Fluorescence image-guided surgery; Mini-invasive surgery; 535; 621.3
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APA ·
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APA (6th Edition):
Dorval, P. (2015). Miniaturisation des technologies d'imagerie de fluorescence pour assister la chirurgie mini-invasive : The miniaturization of fluorescence image guided technologies to assist minimally invasive surgery. (Doctoral Dissertation). Université de Strasbourg. Retrieved from http://www.theses.fr/2015STRAD005
Chicago Manual of Style (16th Edition):
Dorval, Paul. “Miniaturisation des technologies d'imagerie de fluorescence pour assister la chirurgie mini-invasive : The miniaturization of fluorescence image guided technologies to assist minimally invasive surgery.” 2015. Doctoral Dissertation, Université de Strasbourg. Accessed January 18, 2021.
http://www.theses.fr/2015STRAD005.
MLA Handbook (7th Edition):
Dorval, Paul. “Miniaturisation des technologies d'imagerie de fluorescence pour assister la chirurgie mini-invasive : The miniaturization of fluorescence image guided technologies to assist minimally invasive surgery.” 2015. Web. 18 Jan 2021.
Vancouver:
Dorval P. Miniaturisation des technologies d'imagerie de fluorescence pour assister la chirurgie mini-invasive : The miniaturization of fluorescence image guided technologies to assist minimally invasive surgery. [Internet] [Doctoral dissertation]. Université de Strasbourg; 2015. [cited 2021 Jan 18].
Available from: http://www.theses.fr/2015STRAD005.
Council of Science Editors:
Dorval P. Miniaturisation des technologies d'imagerie de fluorescence pour assister la chirurgie mini-invasive : The miniaturization of fluorescence image guided technologies to assist minimally invasive surgery. [Doctoral Dissertation]. Université de Strasbourg; 2015. Available from: http://www.theses.fr/2015STRAD005
29.
Novellino, Marcelo Michele.
Desvios lineares e angulares de implantes com guias prototipadas fixadas em modelos experimentais.
Degree: Mestrado, Prótese Dentária, 2011, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/23/23150/tde-26092011-155156/
;
► Considerando as dificuldades que ocorrem com a localização e o posicionamento de implantes e, ainda, o risco de deslocamento das guias, tomográfica e cirúrgica, durante…
(more)
▼ Considerando as dificuldades que ocorrem com a localização e o posicionamento de implantes e, ainda, o risco de deslocamento das guias, tomográfica e cirúrgica, durante os procedimentos de diagnóstico e cirúrgico, foi objetivo desta pesquisa avaliar, se a alternativa de introduzir dispositivos para retenção e suporte, nas guias da técnica de cirurgia guiada convencional, interfere na posição e inclinação de implantes no momento da sua colocação. Foram confeccionados 10 modelos simulando tecido ósseo, divididos aleatoriamente em 2 grupos: 5 com a guia tomográfica e cirúrgica da técnica convencional, denominado grupo controle (M); 5 com as guias fixadas a ortoimplantes modificados associados ao sistema de encaixe o ring, representando o grupo experimental (MI). A avaliação dos resultados foi pela sobreposição dos planejamentos virtuais (Implant Viewer), derivados de tomografias computadorizadas pré-cirúrgicas, com as realizadas após a colocação dos implantes. Os resultados obtidos mostraram que não houve diferenças estatisticamente significantes para os desvios angulares (Teste Tukey F= 1,06 e p= 0, 3124) e lineares (Teste ANOVA F = 2,54 e p = 0,11). No entanto, os valores angulares individuais do grupo experimental (MI), mostraram ser mais próximos entre si, com menor variabilidade, quando comparados ao grupo controle. Concluiuse, que o uso de ortoimplantes associados ao sistema de encaixe o ring, pode trazer benefícios à técnica da cirurgia guiada convencional, reduzindo as alterações de posicionamento dos implantes no momento da sua colocação.
Computer guided surgery is an excellent alternative to the proper insertion of implants in patients with an edentulous arch or a partially edentulous area and with appropriate quantity of bone. Considering the difficulties that occur with implants placement and the risk of displacement of radiographic and surgical template during the diagnostic and surgical procedures, the aim of this research was to assess if an alternative devices for retention of radiographic and surgical templates can bring benefits for a more accurate implant placement. Ten models made by a material that simulates bone tissue were randomly divided into 2 groups: 5 with the conventional radiographic and surgical guide, which was called control group (M); 5 with modified orthodontic implants that fixed the radiographic and the surgical templates, representing the experimental group (MI). The evaluation of the results was by matching virtual plans (Implant Viewer), derived from pre-operative cone-beam CT images, with post-operative ones to calculate the deviation between planned and installed implants. The results showed that there was no statistically significant differences for angular (Tukey F = 1.06 and p = 0, 3124) and linear deviations (test ANOVA F = 2.54 and p = 0.11). However, the individual angular values of experimental group (MI) showed to be closer to each other, with lower variability when compared to control group. It was concluded that the use of modified orthodontic implant with o ring…
Advisors/Committee Members: Lagana, Dalva Cruz.
Subjects/Keywords: Cirurgia assistida por computador; Cirurgia guiada por imagem; Computer-assisted surgery; Dental implants; Image guided surgery; Implantes dentários
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APA (6th Edition):
Novellino, M. M. (2011). Desvios lineares e angulares de implantes com guias prototipadas fixadas em modelos experimentais. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/23/23150/tde-26092011-155156/ ;
Chicago Manual of Style (16th Edition):
Novellino, Marcelo Michele. “Desvios lineares e angulares de implantes com guias prototipadas fixadas em modelos experimentais.” 2011. Masters Thesis, University of São Paulo. Accessed January 18, 2021.
http://www.teses.usp.br/teses/disponiveis/23/23150/tde-26092011-155156/ ;.
MLA Handbook (7th Edition):
Novellino, Marcelo Michele. “Desvios lineares e angulares de implantes com guias prototipadas fixadas em modelos experimentais.” 2011. Web. 18 Jan 2021.
Vancouver:
Novellino MM. Desvios lineares e angulares de implantes com guias prototipadas fixadas em modelos experimentais. [Internet] [Masters thesis]. University of São Paulo; 2011. [cited 2021 Jan 18].
Available from: http://www.teses.usp.br/teses/disponiveis/23/23150/tde-26092011-155156/ ;.
Council of Science Editors:
Novellino MM. Desvios lineares e angulares de implantes com guias prototipadas fixadas em modelos experimentais. [Masters Thesis]. University of São Paulo; 2011. Available from: http://www.teses.usp.br/teses/disponiveis/23/23150/tde-26092011-155156/ ;
30.
Δασκαλάκη, Αναστασία.
Υπολογισμός οπτικού πεδίου ενδοσκοπικής κάμερας και εφαρμογή σε σύστημα επαυξημένης πραγματικότητας για υποβοήθηση του χειρουργού.
Degree: 2012, University of Patras
URL: http://hdl.handle.net/10889/5276
► Ο σκοπός της διπλωματικής εργασίας ήταν η ανάπτυξη ενός μοντέλου Επαυξημένης Πραγματικότητας για την υποβοήθηση του χειρουργού-χειριστή ρομποτικού μηχανήματος. Το μοντέλο αυτό παρουσιάστηκε για την…
(more)
▼ Ο σκοπός της διπλωματικής εργασίας ήταν η ανάπτυξη ενός μοντέλου Επαυξημένης Πραγματικότητας για την υποβοήθηση του χειρουργού-χειριστή ρομποτικού μηχανήματος. Το μοντέλο αυτό παρουσιάστηκε για την εύρεση του οπτικού πεδίου του ειδικού ενδοσκοπίου. Για τον σκοπό αυτό κατασκευάστηκαν δύο προγράμματα τα οποία μπορούν να χειριστούν ιατρικά δεδομένα και να προσφέρουν εικόνες από το εσωτερικό του μοντέλου του ασθενούς.
Συγκεκριμένα, έγινε μελέτη των βασικών μεθόδων εφαρμογής Επαυξημένης Πραγματικότητας στην χειρουργική, όπως η εγγραφή του ασθενούς, η κατάτμηση των ιατρικών δεδομένων, η τρισδιάστατη ανακατασκευή τους και η ανίχνευση των ενδοσκοπικών εργαλείων και της κάμερας. Παρουσιάστηκε το πλήρες θεωρητικό μοντέλο εφαρμογής επαυξημένης πραγματικότητας και έγινε ανάλυση των επιμέρους διαδικασιών. Κατασκευάστηκαν με την βοήθεια της Matlab δύο προγράμματα με τα αντίστοιχα GUIs για τον προεγχειρητικό σχεδιασμό και την διεγχειρητική καθοδήγηση/επαύξηση αντίστοιχα. Τέλος έγινε δοκιμή των προγραμμάτων χρησιμοποιώντας 22 τομές μαγνητικής τομογραφίας (μορφής DICOM) εγκεφάλου με εμφανή καρκίνο στην αριστερή κοιλία. Επίσης καταγράφηκαν οι εικόνες και τα δεδομένα που παίρνουμε σε κάθε βήμα εφαρμογής των προγραμμάτων με στόχο την αξιολόγηση τους.
Το μοντέλο αυτό κατασκευάστηκε με στόχο την εφαρμογή του σε επεμβάσεις μέσω του ρομποτικού μηχανήματος daVinci. Παρόλα αυτά η γενικότερη εφαρμογή της μεθοδολογίας που αναπτύσσεται μπορεί να βρει εφαρμογές και σε άλλες ενδοσκοπικές επεμβάσεις.
The purpose of this thesis was to develop a model of Augmented Reality to assist the surgeon-operator of a robotic machine. The model has been presented for finding the field of special endoscope. For this purpose we built two programs that can manipulate medical data and provide images of the interior of the patient’s model.
Specifically, a study was done in the basic methods of Augmented Reality application in Surgery such as, the registration of the patient, the segmentation of medical data, their 3D reconstruction and the detection of endoscopic instruments and the camera. Has been presented the complete theoretical model for applying augmented reality and an analysis of individual procedures was done. Moreover we constructed with the help of Matlab two programs with their GUIs, for preoperative planning and intraoperative guidance/augmentation, respectively. Finally the programs were tested, using 22 MRI slices (format DICOM) with visible brain cancer in the left ventricle. Also were recorded images and data that we get at each step of programs implementation in order to evaluate them.
This model was constructed to implement the operations through the daVinci robotic machine. Nevertheless, the general application of the methodology developed in this study may find applications also in other endoscopic procedures
Advisors/Committee Members: Κουτσούρης, Δημήτρης, Daskalaki, Anastasia, Παυλόπουλος, Σωτήρης, Τσανάκας, Παναγιώτης, Κουτσούρης, Δημήτρης.
Subjects/Keywords: Επαυξημένη πραγματικότητα; Ρομποτική χειρουργική; Εγχείρηση καθοδηγούμενη από εικόνα; 610.284; Augmented reality; Robotic surgery; Image guided surgery
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APA ·
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APA (6th Edition):
Δασκαλάκη, . (2012). Υπολογισμός οπτικού πεδίου ενδοσκοπικής κάμερας και εφαρμογή σε σύστημα επαυξημένης πραγματικότητας για υποβοήθηση του χειρουργού. (Masters Thesis). University of Patras. Retrieved from http://hdl.handle.net/10889/5276
Chicago Manual of Style (16th Edition):
Δασκαλάκη, Αναστασία. “Υπολογισμός οπτικού πεδίου ενδοσκοπικής κάμερας και εφαρμογή σε σύστημα επαυξημένης πραγματικότητας για υποβοήθηση του χειρουργού.” 2012. Masters Thesis, University of Patras. Accessed January 18, 2021.
http://hdl.handle.net/10889/5276.
MLA Handbook (7th Edition):
Δασκαλάκη, Αναστασία. “Υπολογισμός οπτικού πεδίου ενδοσκοπικής κάμερας και εφαρμογή σε σύστημα επαυξημένης πραγματικότητας για υποβοήθηση του χειρουργού.” 2012. Web. 18 Jan 2021.
Vancouver:
Δασκαλάκη . Υπολογισμός οπτικού πεδίου ενδοσκοπικής κάμερας και εφαρμογή σε σύστημα επαυξημένης πραγματικότητας για υποβοήθηση του χειρουργού. [Internet] [Masters thesis]. University of Patras; 2012. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/10889/5276.
Council of Science Editors:
Δασκαλάκη . Υπολογισμός οπτικού πεδίου ενδοσκοπικής κάμερας και εφαρμογή σε σύστημα επαυξημένης πραγματικότητας για υποβοήθηση του χειρουργού. [Masters Thesis]. University of Patras; 2012. Available from: http://hdl.handle.net/10889/5276
◁ [1] [2] [3] ▶
. 
Open Access Theses and Dissertations