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Universitat Pompeu Fabra

1. Aragón Manresa, Ferran. The role of vHnf1 and Fgf Signaling in the caudal Hindbrain Patterning.

Degree: Departament de Ciències Experimentals i de la Salut, 2008, Universitat Pompeu Fabra

During early embryonic development of chordates, the hindbrain, which is the caudalmost brain vesicle, is transiently organized along the AP axis in a series of segments called rhombomeres (r). This segmental organization serves as scaffold for several structures that develop within the hindbrain in repeated patterns. Each rhombomere has a molecular identity given by a specific combination of gene expression. Rhombomeric identity is the result of a progressively refined patterning that involves the interplay of different cell signaling pathways and rhombomere-specific transcription factors. In the present project the role of vHnf1, one of the earliest transcription factors expressed in the hindbrain, and its interplay with FGF signaling has been analyzed during the chick embryo development. The results show that vHnf1 is very early expressed in the chick neuroepithelium with a sharp boundary of expression coinciding with the presumptive r4/r5 interrhombomeric boundary. Gain-of-function experiments demonstrated that vHnf1 is able to confer partial caudal character to rostral rhombomeres through the mediation of FGF signaling. We also analyzed the expression of genes of the FGF synexpression group in the caudal hindbrain. Finally, we determined that the role of FGF signaling in regulating the caudal rhombomeric markers Krox20 and MafB is mediated through the Ras-ERK1/2 intracellular pathway. The results of this project provide new information about the molecular mechanisms involved in patterning the vertebrate caudal hindbrain. Interestingly, while requirement of vHnf1 and FGF signaling for caudal hindbrain patterning is an evolutionary conserved feature, the ways by which FGF signals are regulated during this process differ across species. Advisors/Committee Members: [email protected] (authoremail), true (authoremailshow), Pujades Corbi, Cristina (director).

Subjects/Keywords: interrhombomeric boundary; in situ hybridization technique; homeotic change; hindbrain/rombencephalon; gene regulation; embryonic development; central nervous system; cellular compartment; cell signaling; cell fate; cell-autonomous effect; anteroposterior axis; factor de transcripció; segmentació; centre de senyalització; rombòmer; especificació regional; identitat posicional; sobrexpressió; placa neural/tub neural; epiteli neural/ectoderm neural; morfògen /mol·lècula de senyalització; frontera interrombomèrica; tècnica d'hibridació in situ; canvi homeòtic; cervell posterior/ romboencèfal; regulació gènica; desenvolupament embrionari; sistema nerviós central; compartiment cel·lular; senyalització cel·lular; destí cel·lular; effecte autònom cel·lular; eix anteroposterior; morphogen/signaling molecule; neuroepithelium/neuroectoderm; neural plate/neural tube; overexpression; positional identity; regional specification/patterning; rhombomere; signaling center; segmentation; transcription factor; 577; 59

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APA (6th Edition):

Aragón Manresa, F. (2008). The role of vHnf1 and Fgf Signaling in the caudal Hindbrain Patterning. (Thesis). Universitat Pompeu Fabra. Retrieved from http://hdl.handle.net/10803/7147

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Aragón Manresa, Ferran. “The role of vHnf1 and Fgf Signaling in the caudal Hindbrain Patterning.” 2008. Thesis, Universitat Pompeu Fabra. Accessed July 21, 2019. http://hdl.handle.net/10803/7147.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Aragón Manresa, Ferran. “The role of vHnf1 and Fgf Signaling in the caudal Hindbrain Patterning.” 2008. Web. 21 Jul 2019.

Vancouver:

Aragón Manresa F. The role of vHnf1 and Fgf Signaling in the caudal Hindbrain Patterning. [Internet] [Thesis]. Universitat Pompeu Fabra; 2008. [cited 2019 Jul 21]. Available from: http://hdl.handle.net/10803/7147.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Aragón Manresa F. The role of vHnf1 and Fgf Signaling in the caudal Hindbrain Patterning. [Thesis]. Universitat Pompeu Fabra; 2008. Available from: http://hdl.handle.net/10803/7147

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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