subject:(high glucose)

1. 奥⽥, ⿇貴⼦. Effects of High Glucose for Hard Tissue Formation on Type II Diabetes Model Rat Bone Marrow Cells In Vitro : Ⅱ型糖尿病モデルラット骨髄細胞の硬組織形成に及ぼす高濃度グルコースの影響.

Degree: 博士（歯学）, 2016, Osaka Dental University / 大阪歯科大学

URL: http://id.nii.ac.jp/1392/00000079/

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Diabetes mellitus (DM) is one of the main etiologies and risk factors for periodontal disease, and is an important concern in periodontal medicine. It has… (more)

Subjects/Keywords: Hard tissue differentiation; High glucose; Inflammatory cytokine; Hard tissue differentiation; High glucose; Inflammatory cytokine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

奥⽥, �. (2016). Effects of High Glucose for Hard Tissue Formation on Type II Diabetes Model Rat Bone Marrow Cells In Vitro : Ⅱ型糖尿病モデルラット骨髄細胞の硬組織形成に及ぼす高濃度グルコースの影響. (Thesis). Osaka Dental University / 大阪歯科大学. Retrieved from http://id.nii.ac.jp/1392/00000079/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

奥⽥, ⿇貴⼦. “Effects of High Glucose for Hard Tissue Formation on Type II Diabetes Model Rat Bone Marrow Cells In Vitro : Ⅱ型糖尿病モデルラット骨髄細胞の硬組織形成に及ぼす高濃度グルコースの影響.” 2016. Thesis, Osaka Dental University / 大阪歯科大学. Accessed January 17, 2021. http://id.nii.ac.jp/1392/00000079/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

奥⽥, ⿇貴⼦. “Effects of High Glucose for Hard Tissue Formation on Type II Diabetes Model Rat Bone Marrow Cells In Vitro : Ⅱ型糖尿病モデルラット骨髄細胞の硬組織形成に及ぼす高濃度グルコースの影響.” 2016. Web. 17 Jan 2021.

Vancouver:

奥⽥ �. Effects of High Glucose for Hard Tissue Formation on Type II Diabetes Model Rat Bone Marrow Cells In Vitro : Ⅱ型糖尿病モデルラット骨髄細胞の硬組織形成に及ぼす高濃度グルコースの影響. [Internet] [Thesis]. Osaka Dental University / 大阪歯科大学; 2016. [cited 2021 Jan 17]. Available from: http://id.nii.ac.jp/1392/00000079/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

奥⽥ �. Effects of High Glucose for Hard Tissue Formation on Type II Diabetes Model Rat Bone Marrow Cells In Vitro : Ⅱ型糖尿病モデルラット骨髄細胞の硬組織形成に及ぼす高濃度グルコースの影響. [Thesis]. Osaka Dental University / 大阪歯科大学; 2016. Available from: http://id.nii.ac.jp/1392/00000079/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Sapienza, Andréia David. Fatores preditores do uso de insulina em pacientes com diabetes melito gestacional diagnosticado pelo teste de tolerância à glicose oral de 100 gramas.

Degree: Mestrado, Obstetrícia e Ginecologia, 2009, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5139/tde-29042009-132253/ ;

► Objetivo: O objetivo desse estudo foi identificar a associação entre fatores clínicos e laboratoriais com o uso de insulina em gestantes com DMG no momento… (more)

▼ Objetivo: O objetivo desse estudo foi identificar a associação entre fatores clínicos e laboratoriais com o uso de insulina em gestantes com DMG no momento do diagnóstico e analisar os possíveis fatores preditores do uso de insulina. Método: Foram estudadas, de forma retrospectiva, 294 pacientes com diabetes melito gestacional (DMG) diagnosticado por meio do teste de tolerância à glicose oral de 100 gramas (TTGO-100g) entre 24 e 33 semanas completas de gestação, cujo seguimento pré-natal foi realizado ambulatorialmente pelo setor de Endocrinopatias e Gestação da Clínica Obstétrica do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, no período de 1 de julho de 2002 a 30 de junho de 2008. Os seguintes fatores clínicos e laboratoriais, que pudessem estar associados ao uso de insulina para controle glicêmico, foram analisados: idade materna, obesidade pré-gestacional - índice de massa corpórea (IMC) > 30 Kg/m2, antecedente familiar de diabetes melito (DM), tabagismo, hipertensão arterial, uso de corticosteróides sistêmicos, antecedente obstétrico de DMG e de macrossomia fetal, nuliparidade, multiparidade, antecedente obstétricos de natimortos e neomortos, idade gestacional no momento do diagnóstico, gemelidade, índice de líquido amniótico (ILA) aumentado ILA > 18 cm, polidrâmnio (ILA > 25 cm), número de valores anormais do TTGO-100g, glicemia de jejum anormal no TTGO- 100g glicemia de jejum > 95 mg/dL; média das quatro glicemias aferidas no TTGO-100g; valor da glicemia de jejum, de 1ª, 2ª e 3ª horas do TTGO-100g e hemoglobina glicada (HbA1c). A associação entre cada fator e a necessidade de insulinoterapia foi analisada individualmente (2 de Pearson / teste exato de Fisher e teste t de Student). O modelo de regressão logística para a análise multivariada foi usado para predizer a probabilidade desses fatores em relação ao uso de insulina. Resultados: Das 294 pacientes avaliadas, 39,8% (117/294) necessitaram de insulinoterapia para controle glicêmico. Observou-se correlação positiva entre o uso de insulina e obesidade pré-gestacional, antecedente familiar de DM, hipertensão arterial, antecedente obstétrico de DMG e de macrossomia fetal, número de valores anormais no TTGO-100g, glicemia de jejum > 95 mg/dL no TTGO-100g; média das quatro glicemias aferidas no TTGO-100g; valor da glicemia de jejum, de 1ª, 2ª e 3ª horas do TTGO-100g e HbA1c pela análise univariada (P<0,05). Na análise do modelo de regressão logística foram desenvolvidos dois modelos que incluíam os seguintes fatores preditores do uso de insulina: obesidade pré-gestacional, antecedente familiar de DM, número de valores anormais no TTGO-100g (só modelo 1) e valor da glicemia de jejum do TTGO-100g (só modelo 2). Os dois primeiros modelos foram novamente analisados, incluindo-se a variável HbA1c para verificação de sua contribuição na predição do uso de insulina. Curvas de probabilidade e escores foram construídos com base nas quatro combinações de fatores preditores. Conclusões: É possível estimar a probabilidade do uso de… Advisors/Committee Members: Francisco, Rossana Pulcineli Vieira.

Subjects/Keywords: Diabetes gestacional; Gestational diabetes; Glucose intolerance; Glucose tolerance test; Gravidez de alto risco; High risk pregnancy; Insulin; Insulina; Intolerância à glucose; Logistic model; Modelos logísticos; Teste de tolerância a glucose

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sapienza, A. D. (2009). Fatores preditores do uso de insulina em pacientes com diabetes melito gestacional diagnosticado pelo teste de tolerância à glicose oral de 100 gramas. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5139/tde-29042009-132253/ ;

Chicago Manual of Style (16^th Edition):

Sapienza, Andréia David. “Fatores preditores do uso de insulina em pacientes com diabetes melito gestacional diagnosticado pelo teste de tolerância à glicose oral de 100 gramas.” 2009. Masters Thesis, University of São Paulo. Accessed January 17, 2021. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-29042009-132253/ ;.

MLA Handbook (7^th Edition):

Sapienza, Andréia David. “Fatores preditores do uso de insulina em pacientes com diabetes melito gestacional diagnosticado pelo teste de tolerância à glicose oral de 100 gramas.” 2009. Web. 17 Jan 2021.

Vancouver:

Sapienza AD. Fatores preditores do uso de insulina em pacientes com diabetes melito gestacional diagnosticado pelo teste de tolerância à glicose oral de 100 gramas. [Internet] [Masters thesis]. University of São Paulo; 2009. [cited 2021 Jan 17]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5139/tde-29042009-132253/ ;.

Council of Science Editors:

Sapienza AD. Fatores preditores do uso de insulina em pacientes com diabetes melito gestacional diagnosticado pelo teste de tolerância à glicose oral de 100 gramas. [Masters Thesis]. University of São Paulo; 2009. Available from: http://www.teses.usp.br/teses/disponiveis/5/5139/tde-29042009-132253/ ;

3. 池,菊芳. Effects of Eplerenone on the Activation of Matrix Metalloprotainase-2 Stimulated by High Glucose and Interleukin-1β in Human Cardiac Fibroblasts : ヒト心臓線維芽細胞における高グルコース及びインターロイキン-1βの刺激によるマトリックスメタロプロテアーゼ-2活性に対するエプレレノンの効果.

Degree: 博士(医学), 2014, University of Fukui / 福井大学

URL: http://hdl.handle.net/10098/8454

以下に掲載 : Genetics and Molecular Research : GMR 13(3) pp.4845-4855 2014. The Ribeirao Preto foundation for Scientific Research. DOI:10.4238/2014.January.24.4 共著者 : J. Chi, H. Uzui, H. Guo, T. Ueda, J. D. Lee

Subjects/Keywords: Fibroblasts; High glucose; Matrix metalloproteinase-2; Interleukin-1b; Mineralocorticoid receptor antagonists

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

池,菊芳. (2014). Effects of Eplerenone on the Activation of Matrix Metalloprotainase-2 Stimulated by High Glucose and Interleukin-1β in Human Cardiac Fibroblasts : ヒト心臓線維芽細胞における高グルコース及びインターロイキン-1βの刺激によるマトリックスメタロプロテアーゼ-2活性に対するエプレレノンの効果. (Thesis). University of Fukui / 福井大学. Retrieved from http://hdl.handle.net/10098/8454

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

池,菊芳. “Effects of Eplerenone on the Activation of Matrix Metalloprotainase-2 Stimulated by High Glucose and Interleukin-1β in Human Cardiac Fibroblasts : ヒト心臓線維芽細胞における高グルコース及びインターロイキン-1βの刺激によるマトリックスメタロプロテアーゼ-2活性に対するエプレレノンの効果.” 2014. Thesis, University of Fukui / 福井大学. Accessed January 17, 2021. http://hdl.handle.net/10098/8454.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

池,菊芳. “Effects of Eplerenone on the Activation of Matrix Metalloprotainase-2 Stimulated by High Glucose and Interleukin-1β in Human Cardiac Fibroblasts : ヒト心臓線維芽細胞における高グルコース及びインターロイキン-1βの刺激によるマトリックスメタロプロテアーゼ-2活性に対するエプレレノンの効果.” 2014. Web. 17 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

池,菊芳. Effects of Eplerenone on the Activation of Matrix Metalloprotainase-2 Stimulated by High Glucose and Interleukin-1β in Human Cardiac Fibroblasts : ヒト心臓線維芽細胞における高グルコース及びインターロイキン-1βの刺激によるマトリックスメタロプロテアーゼ-2活性に対するエプレレノンの効果. [Internet] [Thesis]. University of Fukui / 福井大学; 2014. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10098/8454.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

池,菊芳. Effects of Eplerenone on the Activation of Matrix Metalloprotainase-2 Stimulated by High Glucose and Interleukin-1β in Human Cardiac Fibroblasts : ヒト心臓線維芽細胞における高グルコース及びインターロイキン-1βの刺激によるマトリックスメタロプロテアーゼ-2活性に対するエプレレノンの効果. [Thesis]. University of Fukui / 福井大学; 2014. Available from: http://hdl.handle.net/10098/8454

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

University of Rochester

4. Gorman-Wheeler, Sadie Grayce. Mice Lacking the Organic Solute Transporter Ostα-Ostβ have Altered Lipid and Glucose Homeostasis.

Degree: PhD, 2014, University of Rochester

URL: http://hdl.handle.net/1802/28973

► The organic solute transporter alpha-beta (Ostα-Ostβ) is an important transporter in the enterohepatic circulation of bile acids. Located on the basolateral side of ileal enterocytes,… (more)

▼ The organic solute transporter alpha-beta (Ostα-Ostβ) is an important transporter in the enterohepatic circulation of bile acids. Located on the basolateral side of ileal enterocytes, it mediates the efflux of bile acids from enterocytes into portal circulation for return to the liver. Ostα-Ostβ mice have reduced bile acid synthesis, as evidenced by lower expression of the rate-limiting enzyme in the classical pathway of bile acid synthesis, Cyp7a1, and their bile acid pool size is greatly diminished. Consistent with reduced bile acid levels, these mice have an impairment in dietary lipid absorption. These studies aimed to characterize Ostα-Ostβ mice in terms of their lipid accumulation and glucose homeostasis. Because wild type C57Bl6 mice exhibit weight gain and insulin desensitization with age and initial studies in neonatal mice indicated a growth retardation in Ostα-Ostβ mice, we hypothesized that Ostα-Ostβ mice are resistant to the agerelated weight gain and insulin desensitization that wild type mice exhibit. Interestingly, particularly in males, Ostα-Ostβ mice gained less weight with age than wild type mice, had smaller fat pads at 12 months, did not accumulate increased liver lipids or exhibit insulin desensitization with age, and lived slightly longer than wild type mice. At both 5 and 12 months, male Ostα-Ostβ mice had increased fecal lipid levels and had lower muscle triglyceride content, and at 5 months, had slightly improved glucose tolerance over wild type. Insulin-stimulated AKT phosphorylation was measured in livers and muscle tissue from 12 month mice, and both male and female Ostα-Ostβ mice showed greater insulin responsiveness. Food consumption, energy expenditure, and activity levels appeared to be normal, suggesting that impaired dietary lipid absorption is an important factor in decreased lipid accumulation. Gene expression analysis showed changes consistent with decreased dietary lipid absorption, with decreased expression of the cholesterol uptake transporter Npc1L1 in the distal portion of the small intestine, and decreased expression of the cholesterol efflux tranporter Abca1 in each section of the small intestine, each observed at both 5 and 12 months of age. In addition, hepatic expression of the cholesterol synthesis enzymes Hmgcr, Mvd, and Fdft was increased, suggesting cholesterol synthesis may be increased to compensate for decreased absorption from the diet. Together, these data indicate that Ost!-/- mice are resistant to many of the agerelated impairments in lipid and glucose homeostasis that wild type mice exhibit and suggest that impaired dietary lipid absorption is an important factor in these changes. To test whether Ostα-Ostβ mice are resistant to diet-induced weight gain, mice were placed on a high fat western diet or a low fat diet control. Interestingly, while Ostα-Ostβ mice on the low fat diet control were significantly smaller than wild type mice, after 12 weeks on the western diet, there was no significant difference in body weight even though…

Subjects/Keywords: Bile Acid; Glucose Homeostasis; Lipid Homeostasis; Insulin Sensitivity; High Fat Diet

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gorman-Wheeler, S. G. (2014). Mice Lacking the Organic Solute Transporter Ostα-Ostβ have Altered Lipid and Glucose Homeostasis. (Doctoral Dissertation). University of Rochester. Retrieved from http://hdl.handle.net/1802/28973

Chicago Manual of Style (16^th Edition):

Gorman-Wheeler, Sadie Grayce. “Mice Lacking the Organic Solute Transporter Ostα-Ostβ have Altered Lipid and Glucose Homeostasis.” 2014. Doctoral Dissertation, University of Rochester. Accessed January 17, 2021. http://hdl.handle.net/1802/28973.

MLA Handbook (7^th Edition):

Gorman-Wheeler, Sadie Grayce. “Mice Lacking the Organic Solute Transporter Ostα-Ostβ have Altered Lipid and Glucose Homeostasis.” 2014. Web. 17 Jan 2021.

Vancouver:

Gorman-Wheeler SG. Mice Lacking the Organic Solute Transporter Ostα-Ostβ have Altered Lipid and Glucose Homeostasis. [Internet] [Doctoral dissertation]. University of Rochester; 2014. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/1802/28973.

Council of Science Editors:

Gorman-Wheeler SG. Mice Lacking the Organic Solute Transporter Ostα-Ostβ have Altered Lipid and Glucose Homeostasis. [Doctoral Dissertation]. University of Rochester; 2014. Available from: http://hdl.handle.net/1802/28973

Loyola University Chicago

5. Goodman, Abigail. Expression and Regulation of Osteopontin in the Diabetic Heart.

Degree: PhD, Physiology, 2011, Loyola University Chicago

URL: https://ecommons.luc.edu/luc_diss/218

► Diabetes leads to several alterations in cardiac structure, one of which is fibrosis of the ventricular myocardium. Myocardial fibrosis is a common underlying factor… (more)

▼ Diabetes leads to several alterations in cardiac structure, one of which is fibrosis of the ventricular myocardium. Myocardial fibrosis is a common underlying factor in most cardiac pathologies. Osteopontin (OPN) is a small phospho-protein that has been implicated in fibrotic tissue remodeling. In the heart, the expression of OPN protein is increased after acute and chronic pathologies. Upregulation of OPN coincides with a transition to heart failure and a direct role for OPN in the progression of diabetic cardiomyopathy to heart failure has been reported. The overall objective of this project is to determine if OPN is upregulated in the heart in a model of type 2 diabetes and if OPN is increased in cardiac cells in response to high glucose. The hypotheses of the project are that OPN expression is increased in the type 2 diabetic heart, cardiac cells contribute to the increased OPN expression in the heart, and high glucose increases OPN expression in cardiac cells. Our proposed pathway of high glucose induced OPN expression is mediated by Angiotensin II (Ang II) and protein kinase C (PKC). In this study I use a type 2 diabetic rat model to determine if OPN expression is increased in the LV. Isolated neonatal rat ventricular myocytes and fibroblasts were used to determine upregulation of high glucose in cardiac cells and to elucidate the regulation of OPN expression in response to high glucose by Ang II and PKC. My results show that OPN expression is increased in the LV of a model of type 2 diabetes. Further I determined that both myocytes and fibroblasts increase OPN expression in response to high glucose. Inhibition of Ang II receptors and production decreased OPN expression in response to high glucose. To determine PKC regulation of OPN expression general and classical PKC inhibitors were used, both of which inhibited increased OPN expression in response to high glucose. A role for PKC in OPN expression was determined by overexpressing constitutively active and dominant negative recombinant PKC proteins. These results provide a better understanding of the signal transduction pathways leading to the cardiac dysfunction seen in diabetic patients.

Subjects/Keywords: Cardiac; Cardiac fibroblasts; Cardiomyocytes; Diabetes; High Glucose; Osteopontin; Physiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Goodman, A. (2011). Expression and Regulation of Osteopontin in the Diabetic Heart. (Doctoral Dissertation). Loyola University Chicago. Retrieved from https://ecommons.luc.edu/luc_diss/218

Chicago Manual of Style (16^th Edition):

Goodman, Abigail. “Expression and Regulation of Osteopontin in the Diabetic Heart.” 2011. Doctoral Dissertation, Loyola University Chicago. Accessed January 17, 2021. https://ecommons.luc.edu/luc_diss/218.

MLA Handbook (7^th Edition):

Goodman, Abigail. “Expression and Regulation of Osteopontin in the Diabetic Heart.” 2011. Web. 17 Jan 2021.

Vancouver:

Goodman A. Expression and Regulation of Osteopontin in the Diabetic Heart. [Internet] [Doctoral dissertation]. Loyola University Chicago; 2011. [cited 2021 Jan 17]. Available from: https://ecommons.luc.edu/luc_diss/218.

Council of Science Editors:

Goodman A. Expression and Regulation of Osteopontin in the Diabetic Heart. [Doctoral Dissertation]. Loyola University Chicago; 2011. Available from: https://ecommons.luc.edu/luc_diss/218

Vanderbilt University

6. Suarez, Sandra. An Investigation of the GAPDH/Siah1 Pathway in Human Retinal Pericyte Apoptosis.

Degree: PhD, Cell and Developmental Biology, 2015, Vanderbilt University

URL: http://hdl.handle.net/1803/15158

► Diabetic Retinopathy (DR) is a leading cause of blindness worldwide, and its prevalence is growing. Current therapies for DR address only the later stages of… (more)

Subjects/Keywords: Diabetic retinopathy; cell death; apoptosis; high glucose; GAPDH; Siah1; cell signaling

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Suarez, S. (2015). An Investigation of the GAPDH/Siah1 Pathway in Human Retinal Pericyte Apoptosis. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/15158

Chicago Manual of Style (16^th Edition):

Suarez, Sandra. “An Investigation of the GAPDH/Siah1 Pathway in Human Retinal Pericyte Apoptosis.” 2015. Doctoral Dissertation, Vanderbilt University. Accessed January 17, 2021. http://hdl.handle.net/1803/15158.

MLA Handbook (7^th Edition):

Suarez, Sandra. “An Investigation of the GAPDH/Siah1 Pathway in Human Retinal Pericyte Apoptosis.” 2015. Web. 17 Jan 2021.

Vancouver:

Suarez S. An Investigation of the GAPDH/Siah1 Pathway in Human Retinal Pericyte Apoptosis. [Internet] [Doctoral dissertation]. Vanderbilt University; 2015. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/1803/15158.

Council of Science Editors:

Suarez S. An Investigation of the GAPDH/Siah1 Pathway in Human Retinal Pericyte Apoptosis. [Doctoral Dissertation]. Vanderbilt University; 2015. Available from: http://hdl.handle.net/1803/15158

Penn State University

7. Huang, Kuan-Hsun. Exogenous Lipids Regulate the Development of Hepatic Steatosis in a Lean NAFLD model-fed a High Carbohydrate Diet.

Degree: 2016, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/13342kxh359

► Non-alcoholic fatty liver disease (NAFLD), an umbrella term that encompasses hepatic steatosis, steatohepatitis, fibrosis, and cirrhosis, has become the most common chronic liver disease in… (more)

▼ Non-alcoholic fatty liver disease (NAFLD), an umbrella term that encompasses hepatic steatosis, steatohepatitis, fibrosis, and cirrhosis, has become the most common chronic liver disease in the developed countries. NAFLD has been shown to be positively associated with obesity, and thus not surprisingly the majority of NAFLD studies have utilized obese models to explore NAFLD causality. However, previous studies indicated that 25% of patients with NAFLD are not obese and that 7.4% of lean adults have steatosis, and they are more likely to be younger and female, suggesting that these people with lean NAFLD were metabolically obese. Additionally, insulin resistance is an independent risk factor to the development of lean NAFLD, which has been shown to be related to cardiovascular disease and diabetes mellitus. Therefore, understanding the etiology of lean NAFLD in the early stage of the development of steatosis becomes an urgent need. On the other hand, lifestyle modification intervention including diet and physical activity is believed to improve NAFLD or even reverse it, but very few studies have focused on the reversal of hepatic steatosis in the lean NAFLD model. Thus, the overall research hypothesis in this dissertation is that the exogenous lipids as a form of lipid emulsion (LE) and physical activity are capable to reverse hepatic triacylglycerol (TG) accumulation in the lean mouse model with preexisting steatosis. Previous work in our laboratory indicated that 13.5% (percent of total energy, en-%) Intralipid® given orally ameliorated TG accumulation in the liver of nonobese mice fed a high carbohydrate diet (HCD) for 5 weeks. Here, in my first study (chapter 3) I examined whether HCD can induce hepatic steatosis in a short period of time (8d) and whether Intralipid® and voluntary exercise can prevent liver triacylglycerol (TG) accumulation by regulating the de novo lipogenesis-associated transcripts and the concentrations of total fatty acids, in 8 d, on the development of steatosis in a lean mouse model. The results revealed that hepatic TG contents in the HCD-fed mice were significantly increased, confirmed by Oil Red O staining, suggesting the 8d period of induction of steatosis was sufficient to induce mild steatosis. Supplementation with 13.5% Intralipid®, with or without exercise, also suppressed HCD-induced steatosis. qRT-PCR analysis showed that including 13.5% Intralipid® to the HCD significantly decreased the transcript levels for lipogenesis-associated genes, whereas mice-fed HCD with exercise had less beneficial effect in the early stage of steatosis, as compared to HCD supplemented with 13.5% Intralipid®. Fatty acid profiling also showed a consistency with transcriptional data that the concentration of monounsaturated FA was decreased significantly. As noted in the previous study that HCD is capable to induce mild hepatic steatosis within 8d, I conducted a second study (chapter 4) to test whether the beneficial effect contributed by 13.5% Intralipid® supplementation will be extended to the mouse… Advisors/Committee Members: A. Catharine Ross, Dissertation Advisor/Co-Advisor, A. Catharine Ross, Committee Chair/Co-Chair, Michael H. Green, Committee Member, Connie J. Rogers, Committee Member, Andrew D. Patterson, Outside Member.

Subjects/Keywords: Lean NAFLD; Glucose metabolism; lipidmetabolism; hepatic steatosis; metabolomics; high carbohydrate diet

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Huang, K. (2016). Exogenous Lipids Regulate the Development of Hepatic Steatosis in a Lean NAFLD model-fed a High Carbohydrate Diet. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/13342kxh359

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Huang, Kuan-Hsun. “Exogenous Lipids Regulate the Development of Hepatic Steatosis in a Lean NAFLD model-fed a High Carbohydrate Diet.” 2016. Thesis, Penn State University. Accessed January 17, 2021. https://submit-etda.libraries.psu.edu/catalog/13342kxh359.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Huang, Kuan-Hsun. “Exogenous Lipids Regulate the Development of Hepatic Steatosis in a Lean NAFLD model-fed a High Carbohydrate Diet.” 2016. Web. 17 Jan 2021.

Vancouver:

Huang K. Exogenous Lipids Regulate the Development of Hepatic Steatosis in a Lean NAFLD model-fed a High Carbohydrate Diet. [Internet] [Thesis]. Penn State University; 2016. [cited 2021 Jan 17]. Available from: https://submit-etda.libraries.psu.edu/catalog/13342kxh359.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Huang K. Exogenous Lipids Regulate the Development of Hepatic Steatosis in a Lean NAFLD model-fed a High Carbohydrate Diet. [Thesis]. Penn State University; 2016. Available from: https://submit-etda.libraries.psu.edu/catalog/13342kxh359

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

8. LaPierre, Mary Patricia. Glucagon Action in the Dorsal Vagal Complex and the Regulation of Glucose Homeostasis during High-protein Feeding.

Degree: 2015, University of Toronto

URL: http://hdl.handle.net/1807/74726

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High-protein feeding acutely lowers plasma glucose compared to low-protein feeding, despite a seemingly dichotomous stimulation of circulating glucagon concentration. The physiological function of this postprandial… (more)

Subjects/Keywords: Dorsal Vagal Complex; Glucagon; Glucose Homeostasis; High-protein Feeding; 0719

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APA (6^th Edition):

LaPierre, M. P. (2015). Glucagon Action in the Dorsal Vagal Complex and the Regulation of Glucose Homeostasis during High-protein Feeding. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/74726

Chicago Manual of Style (16^th Edition):

LaPierre, Mary Patricia. “Glucagon Action in the Dorsal Vagal Complex and the Regulation of Glucose Homeostasis during High-protein Feeding.” 2015. Masters Thesis, University of Toronto. Accessed January 17, 2021. http://hdl.handle.net/1807/74726.

MLA Handbook (7^th Edition):

LaPierre, Mary Patricia. “Glucagon Action in the Dorsal Vagal Complex and the Regulation of Glucose Homeostasis during High-protein Feeding.” 2015. Web. 17 Jan 2021.

Vancouver:

LaPierre MP. Glucagon Action in the Dorsal Vagal Complex and the Regulation of Glucose Homeostasis during High-protein Feeding. [Internet] [Masters thesis]. University of Toronto; 2015. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/1807/74726.

Council of Science Editors:

LaPierre MP. Glucagon Action in the Dorsal Vagal Complex and the Regulation of Glucose Homeostasis during High-protein Feeding. [Masters Thesis]. University of Toronto; 2015. Available from: http://hdl.handle.net/1807/74726

Colorado State University

9. Smith, Whitney. Effects of a single bout of exercise on plasma triglycerides, glucose, and insulin following consumption of a high-fat mixed macronutrient meal, The.

Degree: MS(M.S.), Food Science and Human Nutrition, 2011, Colorado State University

URL: http://hdl.handle.net/10217/48139

► Purpose: The aim of the present study was to examine the effect of a single, acute bout of exercise with caloric replacement compared to a… (more)

▼ Purpose: The aim of the present study was to examine the effect of a single, acute bout of exercise with caloric replacement compared to a sedentary condition on plasma triglyceride, glucose, and insulin concentrations in response to a high-fat, mixed macronutrient (HFMM) meal challenge. Methods: Eight non-obese, sedentary females aged 19.6 ± 1.3 years participated in two trials: sedentary (SED) and exercise (EX). For the SED trial, subjects refrained from exercise the evening prior to the next morning's HFMM meal. The EX trial was designed to have subjects cycle at 65% of their VO2peak to produce a net energy cost of 400 calories, with a snack provided shortly after to replace the extra calories expended with exercise. However, due to a methodological error, the net energy cost of exercise was less than the targeted value by approximately 100 kcal, which when accompanied by the replacement energy snack, likely resulted in a small acute positive energy balance. Thus, the unintended research question addressed was whether or not a low intensity bout of exercise could attenuate the postprandial lipemic response to a HFMM meal when subjects slightly overcompensated for their exercise energy expenditure. During the trial day subjects reported to the laboratory following a 12-hour overnight fast. Blood samples were obtained by intravenous cannulation before ingestion of the HFMM meal challenge and at 30, 60, 90, 120, 150, 180, 210, 240, 300, and 360 minutes after ingestion. Plasma was analyzed for triglyceride, glucose, and insulin concentrations, with these variables compared across the SED and EX conditions using a repeated measures analysis of variance. Results: There were no significant treatment by time interactions for any of the dependent variables. Low intensity exercise with modest energy overconsumption failed to attenuate the postprandial triglyceride, glucose, and insulin responses to a HFMM meal challenge in comparison to the SED condition. Conclusion: A low intensity exercise bout accompanied by modest energy overconsumption failed to improve the postprandial response to a HFMM meal challenge compared to the HFMM meal challenge without exercise. Exercise alone may not be beneficial in attenuating postprandial lipemia unless it is accompanied by a resulting acute caloric deficit. Advisors/Committee Members: Melby, Chris (advisor), Hickey, Matt (advisor), Nelson, Tracy (committee member).

Subjects/Keywords: triglyceride; caloric replacement; glucose; high-fat mixed macronutrient; insulin

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APA (6^th Edition):

Smith, W. (2011). Effects of a single bout of exercise on plasma triglycerides, glucose, and insulin following consumption of a high-fat mixed macronutrient meal, The. (Masters Thesis). Colorado State University. Retrieved from http://hdl.handle.net/10217/48139

Chicago Manual of Style (16^th Edition):

Smith, Whitney. “Effects of a single bout of exercise on plasma triglycerides, glucose, and insulin following consumption of a high-fat mixed macronutrient meal, The.” 2011. Masters Thesis, Colorado State University. Accessed January 17, 2021. http://hdl.handle.net/10217/48139.

MLA Handbook (7^th Edition):

Smith, Whitney. “Effects of a single bout of exercise on plasma triglycerides, glucose, and insulin following consumption of a high-fat mixed macronutrient meal, The.” 2011. Web. 17 Jan 2021.

Vancouver:

Smith W. Effects of a single bout of exercise on plasma triglycerides, glucose, and insulin following consumption of a high-fat mixed macronutrient meal, The. [Internet] [Masters thesis]. Colorado State University; 2011. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10217/48139.

Council of Science Editors:

Smith W. Effects of a single bout of exercise on plasma triglycerides, glucose, and insulin following consumption of a high-fat mixed macronutrient meal, The. [Masters Thesis]. Colorado State University; 2011. Available from: http://hdl.handle.net/10217/48139

University of Kansas

10. Raider, Kayla. Effects of a high fat diet on brain metabolism in rats: An in vivo 1H-MRS study.

Degree: MS, Molecular & Integrative Physiology, 2014, University of Kansas

URL: http://hdl.handle.net/1808/23950

► Diet-induced obesity and its metabolic consequences can lead to neurological dysfunction and increase the risk of developing Alzheimer's disease (AD) and Parkinson's disease (PD). Despite… (more)

Subjects/Keywords: Physiology; Brain metabolism; diet-induced obesity; glucose; high fat; imaging

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APA (6^th Edition):

Raider, K. (2014). Effects of a high fat diet on brain metabolism in rats: An in vivo 1H-MRS study. (Masters Thesis). University of Kansas. Retrieved from http://hdl.handle.net/1808/23950

Chicago Manual of Style (16^th Edition):

Raider, Kayla. “Effects of a high fat diet on brain metabolism in rats: An in vivo 1H-MRS study.” 2014. Masters Thesis, University of Kansas. Accessed January 17, 2021. http://hdl.handle.net/1808/23950.

MLA Handbook (7^th Edition):

Raider, Kayla. “Effects of a high fat diet on brain metabolism in rats: An in vivo 1H-MRS study.” 2014. Web. 17 Jan 2021.

Vancouver:

Raider K. Effects of a high fat diet on brain metabolism in rats: An in vivo 1H-MRS study. [Internet] [Masters thesis]. University of Kansas; 2014. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/1808/23950.

Council of Science Editors:

Raider K. Effects of a high fat diet on brain metabolism in rats: An in vivo 1H-MRS study. [Masters Thesis]. University of Kansas; 2014. Available from: http://hdl.handle.net/1808/23950

11. Duraffourd, Céline. Rôle des récepteurs μ-opioïdes dans l’induction de la néoglucogenèse intestinale observée lors d’un régime hyperprotéique : Role of Mu opioid receptors in induction of intestinal glucose production observed on high-protein diets.

Degree: Docteur es, Physiologie, 2010, Université Claude Bernard – Lyon I

URL: http://www.theses.fr/2010LYO10321

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Une alimentation HP permet une importante diminution de la prise alimentaire, chez l’Homme et l’animal, par rapport à une alimentation STD. Les précédents travaux du… (more)

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Une alimentation HP permet une importante diminution de la prise alimentaire, chez l’Homme et l’animal, par rapport à une alimentation STD. Les précédents travaux du laboratoire montrent que le mécanisme d’action des protéines implique une induction de la PIG chez le rat en période post-absorptive. Ce glucose, libéré et détecté dans la veine porte, permet l’activation de noyaux hypothalamiques impliqués dans la régulation des sensations de satiété. L’objectif de ce travail consistait à mettre en évidence le type de peptides pouvant induire la PIG en régime HP et d’essayer de découvrir leur mécanisme d’action. L’activité de la Glc6Pase et de l’expression des protéines Glc6Pase et PEPCK ont été quantifiées chez des rats nourris en régime STD ou HP et perfusés avec des perfusions d’acides aminés, de peptides µ-opioïdes et des solutions de di- ou tri-peptides. Les résultats montrent que le même mécanisme d’action est utilisé par les protéines et les antagonistes µ-opioïdes pour induire la PIG. Des expériences de dénervation portale et une étude immunohistochimique ont démontré la présence de récepteurs µ-opioïdes dans la veine porte probablement impliqués dans cette induction. Des perfusions de di ou tri-peptides chez le rat ont démontré que la PIG était induite par tous les di ou tri-peptides testés. L’étude phénotypique de la souris KO µ-opioïde nourrie en régime STD, HP ou ayant subi des perfusions portales de di ou tri-peptides, ont confirmé que la PIG pouvait être induite par des di ou tri-peptides et que leur mécanisme d’action nécessitait la présence de récepteurs µ-opioïdes. Cette étude suggère que tous les di- ou tri-peptides produits par la dégradation des protéines pourraient induire la PIG par un mécanisme dépendant des récepteurs µ-opioïdes

Protein feeding promotes an important decrease of food intake in humans and animals, compared on chow diet. Previous data show that this mechanism implicates intestinal glucose production (IPG) induction in rat during the post-absorptive time. Glucose released and detected into the portal vein produces an activation of hypothalamic nuclei implicated in the regulation of satiety sensations. The aim of this study was to highlight peptides which could induce IPG on HP diet and try to discoverer them mechanism. Quantification of Glc6Pase and protein expression of Glc6Pase and PEPCK were assessed in rats fed on chow or HP diet and infused with amino acids, µ-opioïd peptides and di- or tri-peptides. Our results show that the same mechanism is shared by both proteins and µ-opioïd antagonists to induce IGP. Experiments of portal vein denervation and an immunochemistry study showed that µ-opioïd receptors are present in the portal vein, probably implicated in this induction. Di or tri-peptides infusions in rat exhibited that the IGP was induced by all tested di or tri-peptides. Phenotypic study of µ-opioid mice fed on chow, HP diet or having undergone portal vein infusions of di or tri-peptides, confirmed that IGP could be induced by di or tri-peptides and their mechanism takes…

Advisors/Committee Members: Mithieux, Gilles (thesis director).

Subjects/Keywords: Régimes hyperprotéiques; Production de glucose; Récepteurs µ-opioïdes; Obésité; Diabète; High-protein diets; Glucose production; Μ-opioïd receptors; Obesity; Diabetes; 612.33

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APA (6^th Edition):

Duraffourd, C. (2010). Rôle des récepteurs μ-opioïdes dans l’induction de la néoglucogenèse intestinale observée lors d’un régime hyperprotéique : Role of Mu opioid receptors in induction of intestinal glucose production observed on high-protein diets. (Doctoral Dissertation). Université Claude Bernard – Lyon I. Retrieved from http://www.theses.fr/2010LYO10321

Chicago Manual of Style (16^th Edition):

Duraffourd, Céline. “Rôle des récepteurs μ-opioïdes dans l’induction de la néoglucogenèse intestinale observée lors d’un régime hyperprotéique : Role of Mu opioid receptors in induction of intestinal glucose production observed on high-protein diets.” 2010. Doctoral Dissertation, Université Claude Bernard – Lyon I. Accessed January 17, 2021. http://www.theses.fr/2010LYO10321.

MLA Handbook (7^th Edition):

Duraffourd, Céline. “Rôle des récepteurs μ-opioïdes dans l’induction de la néoglucogenèse intestinale observée lors d’un régime hyperprotéique : Role of Mu opioid receptors in induction of intestinal glucose production observed on high-protein diets.” 2010. Web. 17 Jan 2021.

Vancouver:

Duraffourd C. Rôle des récepteurs μ-opioïdes dans l’induction de la néoglucogenèse intestinale observée lors d’un régime hyperprotéique : Role of Mu opioid receptors in induction of intestinal glucose production observed on high-protein diets. [Internet] [Doctoral dissertation]. Université Claude Bernard – Lyon I; 2010. [cited 2021 Jan 17]. Available from: http://www.theses.fr/2010LYO10321.

Council of Science Editors:

Duraffourd C. Rôle des récepteurs μ-opioïdes dans l’induction de la néoglucogenèse intestinale observée lors d’un régime hyperprotéique : Role of Mu opioid receptors in induction of intestinal glucose production observed on high-protein diets. [Doctoral Dissertation]. Université Claude Bernard – Lyon I; 2010. Available from: http://www.theses.fr/2010LYO10321

University of Otago

12. Francois, Monique Emily. Exercise Snacking before meals as a novel approach to glycaemic control in pre diabetes .

Degree: 2013, University of Otago

URL: http://hdl.handle.net/10523/4282

► Introduction: An acute bout of exercise increases glucose uptake into skeletal muscle, an effect that persists for several hours and which is insulin-independent. Contraction-stimulated skeletal… (more)

▼ Introduction: An acute bout of exercise increases glucose uptake into skeletal muscle, an effect that persists for several hours and which is insulin-independent. Contraction-stimulated skeletal muscle glucose uptake is unimpaired in individuals with insulin resistance (i.e., pre diabetes). Meal times elicit large perturbations in glucose concentrations in individuals with pre diabetes. These postprandial glucose excursions, the so-called ‘hyperglycaemic spikes’ that are an early and often undetected feature of the insulin resistant state are more predictive for the onset of CVD complications than elevated fasting plasma glucose and are strongly associated with HbA1c content in individuals with pre diabetes. Therefore, pre-meal exercise bouts may be an effective strategy to control blood glucose throughout the day. Such ‘exercise snacking’ might also be effective in lowering blood pressure (BP) and oxidative stress and improving insulin sensitivity. The aims of this study were to examine whether (i) Exercise Snacking would be more effective than traditional exercise guidelines for blood glucose homeostasis and other risk factors of type 2 diabetes, and (ii) the combination of aerobic and resistance intervals (Composite Exercise Snacking, CES) would be as effective as an aerobic interval Exercise Snacking (ES) regime. Methods: Nine participants (7 M & 2 F; 48 ± 6 y; BMI 36 ± 8 kg.m-2, OGTT: FG 6.3 ± 1.2 mmol.L-1 & 2-h GT 9.3 ± 2.6 mmol.L-1) completed three experimental trials, in a randomised order. Trials were conducted over 5 days, under free-living conditions, with exercise performed on the third day, as either: i) Exercise Feasting (EF), comprising 30 min of moderate (60% HRmax) intensity incline walking; ii) Exercise Snacking (ES), 3*(6 x 1-min @ 90% HRmax) incline walking with 1-min min rests (which matched the energy use of EF), or iii) Composite Exercise Snacking (CES), 3*(6 x 1-min -min intervals alternating aerobic (90% HRmax incline walking) and resistance (resistance band exercises). ES and CES were completed 30 min before breakfast, lunch and dinner, whilst EF was prior to dinner only. Blood [glucose] was measured continuously across the 5 days (Medtronic iPro2 CGM), and ambulatory blood pressure was measured hourly across 4 days (Oscar 2 SunTech Medical). Plasma samples (fasting and 1-h postprandial evening meal) provided measures of insulin sensitivity ([glucose]/[insulin]), oxidative stress ([MDA] & [AOPP]) and antioxidant capacity (ORAC) the days before, of and following exercise. Effects of exercise and type were examined using two-way, repeated measures ANOVA (Bonferroni corrected). Results: ES reduced mean 24-h [glucose] on the exercise day and the day following, by 0.6 ± 0.4 mmol.L-1 (p = 0.01) and 0.6 ± 0.6 mmol.L-1 (p = 0.03), respectively compared to EF, relative to the control day before. ES reduced glycaemic variability (SD) by 35% (p = 0.05), postprandial glucose (sum of 3 h: by 0.85 mmol.L-1, p = 0.03), and consequently hyperglycaemia (Area above 6.1 mmol.L-1 by 28%, p = 0.06) on the… Advisors/Committee Members: Cotter, James (advisor).

Subjects/Keywords: Exercise; Diabetes; continuous-blood-glucose-monitoring; glycaemic-control; high-intensity-interval-training; blood-pressure

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Francois, M. E. (2013). Exercise Snacking before meals as a novel approach to glycaemic control in pre diabetes . (Masters Thesis). University of Otago. Retrieved from http://hdl.handle.net/10523/4282

Chicago Manual of Style (16^th Edition):

Francois, Monique Emily. “Exercise Snacking before meals as a novel approach to glycaemic control in pre diabetes .” 2013. Masters Thesis, University of Otago. Accessed January 17, 2021. http://hdl.handle.net/10523/4282.

MLA Handbook (7^th Edition):

Francois, Monique Emily. “Exercise Snacking before meals as a novel approach to glycaemic control in pre diabetes .” 2013. Web. 17 Jan 2021.

Vancouver:

Francois ME. Exercise Snacking before meals as a novel approach to glycaemic control in pre diabetes . [Internet] [Masters thesis]. University of Otago; 2013. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10523/4282.

Council of Science Editors:

Francois ME. Exercise Snacking before meals as a novel approach to glycaemic control in pre diabetes . [Masters Thesis]. University of Otago; 2013. Available from: http://hdl.handle.net/10523/4282

13. 이, 연정. Cellular Mechanism of High Glucose/Palmitate-induced INS-1 Beta Cell Death.

Degree: 2008, Ajou University

URL: http://repository.ajou.ac.kr/handle/201003/1815 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000009214

► Type 2 diabetes is considered to be in most cases a polygenic disease with a strong involvement of environmental factors, such as diet and exercise.… (more)

▼ Type 2 diabetes is considered to be in most cases a polygenic disease with a strong involvement of environmental factors, such as diet and exercise. Chronic exposure of high glucose and free fatty acids (FFAs) induces pancreatic beta cell dysfunction and death, which may contribute to the development of type 2 diabetes. A deficiency of insulin through loss of beta cell mass, and subsequent impaired compensation against insulin resistance is believed to be a pathogenic cause of type 2 diabetes. Pancreatic β-cell mass is regulated by at least four independent mechanisms(i) β-cell replication (i.e., the mitogenic division of existing β cells), (ii) β-cell size, (iii) β-cell neogenesis and (iv) β-cell apoptosis. The sum of the rates of β-cell replication, size, and neogenesis, minus the rate of β-cell apoptosis gives the net rate of β-cell growth(Rhodes et al, 2005). Increased free fatty acid (FFAs), in conjunction with hyperglycemia, have been proposed to provide stimuli triggering the insulin deficiency in type 2 diabetes, since several in vitro studies demonstrated that long-term exposure to saturated FFAs and could induce cell death in cultured beta cells and also in isolated islets. The cellular injury, through excess FFA accompanied by triglyceride accumulation, was termed beta cell glucolipotoxicity. The cellular mechanisms involved in FFA-induced beta cell apoptosis are not fully understood. FFAs are usually non-toxic to beta cells if they are oxidized. However, the accumulation of long chain acyl-CoAs or lipid derivatives, such as, diacylglycerol, lysophosphatidic acid, and sphingolipids, are thought to promote beta cell apoptosis (Assimacopulos et al, 2004). Ceramide has been suggested to be an important mediator of FFA-induced beta cell death (Lupi et al, 2002; Maedler et al, 2001; Shimabukuro et al, 1998; Okuyama et al, 2003). Nuclear translocation and activation of PKC-δ were reported to be necessary for saturated fatty acid-induced beta cell apoptosis (Eitel, 2003). Elevated concentrations of FFAs were found to produce reactive oxygen species (ROS) (Wang et al, 2004) and therefore, ROS and oxidative stress were believed to be involved in FFA-induced beta cell death. On the other hand, inhibition of the IRS/PI3 kinase/Akt signaling pathway was reported to be critical in FFA-induced beta cell apoptosis (Lingohr et al, 2003; Wrede et al, 2002). Recently, endoplasmic reticulum (ER) stress was postulated to be a critical mediator of FFA-induced beta cell apoptosis (Kharroubi et al, 2004; Karaskov et al, 2006) and the involvement of calcium-mediated apoptotic signals was also reported (Choi et al, 2007). To investigate the mechanisms of HG/PA-induced INS-1 beta cells death, we tested the effect of several pharmacological inhibitors. Chronic exposure of free fatty acids (FFAs) in conjunction with high glucose (HG) has been reported to be cytotoxic to beta cells. These works were initiated to elucidate how lipid metabolism elicits glucose/palmitate-induced beta cell cytotoxicity. When the INS-1 beta cells were… Advisors/Committee Members: 대학원 의학과, 200624454, 이, 연정.

Subjects/Keywords: High Glucose; Palmitate; anaplerosis; energy depletion

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APA (6^th Edition):

이, �. (2008). Cellular Mechanism of High Glucose/Palmitate-induced INS-1 Beta Cell Death. (Thesis). Ajou University. Retrieved from http://repository.ajou.ac.kr/handle/201003/1815 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000009214

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

이, 연정. “Cellular Mechanism of High Glucose/Palmitate-induced INS-1 Beta Cell Death.” 2008. Thesis, Ajou University. Accessed January 17, 2021. http://repository.ajou.ac.kr/handle/201003/1815 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000009214.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

이, 연정. “Cellular Mechanism of High Glucose/Palmitate-induced INS-1 Beta Cell Death.” 2008. Web. 17 Jan 2021.

Vancouver:

이 �. Cellular Mechanism of High Glucose/Palmitate-induced INS-1 Beta Cell Death. [Internet] [Thesis]. Ajou University; 2008. [cited 2021 Jan 17]. Available from: http://repository.ajou.ac.kr/handle/201003/1815 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000009214.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

이 �. Cellular Mechanism of High Glucose/Palmitate-induced INS-1 Beta Cell Death. [Thesis]. Ajou University; 2008. Available from: http://repository.ajou.ac.kr/handle/201003/1815 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000009214

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brigham Young University

14. Chen, Ting. LKB1 Regulation of High-Fat Diet-induced Adaptation in Mouse Skeletal Muscle.

Degree: PhD, 2017, Brigham Young University

URL: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7682&context=etd

► Ad libitum high-fat diet (HFD)-induced obesity leads to insulin resistance in skeletal muscle, altered gene expression, and altered growth signaling, all of which contributes to… (more)

▼ Ad libitum high-fat diet (HFD)-induced obesity leads to insulin resistance in skeletal muscle, altered gene expression, and altered growth signaling, all of which contributes to pathological changes in metabolism. Liver kinase B1 (LKB1) is an important metabolism regulator. The purpose of this dissertation was to understand how knocking out LKB1 influences HFD induced adaptations in mouse skeletal muscle. To do so, control and skeletal muscle LKB1 knock-out (LKB1-KO) mice were put on either standard diet (STD) or HFD for 1 week or 14 weeks, or put on the HFD for 14 weeks and then switched to STD for 1 week (switched diet). The major differences in adaptation in the LKB1-KO mice include: 1) lower fasting blood glucose levels but impaired glucose tolerance compared to WT mice (although conflicting results are generated if the data is not normalized to fasting blood glucose levels), 2) altered expression of 16 HFD-induced genes, and 3) decreased muscle weight. The lower fasting blood glucose in LKB1-KO mice was likely due to elevated serum insulin levels, and the impaired glucose tolerance was associated with decreased phosphorylation of TBC1D1, an important regulator of insulin stimulated glucose uptake. 16 potential important target genes (metabolism, mitochondrial, cytoskeleton, cell cycle, cell-cell interactions, enzyme, ion channel) were identified in the context of HFD feeding and LKB1-KO. These genes were quantified by RT-PCR and grouped according to changes in their patterns of expression among the different groups. Among several other interesting changes in gene expression, the muscle growth-related protein, Ky was not affected by short-term HFD, but increased after long-term HFD, and did not decrease after switched diet, showing that its expression may be an important long-term adaptation to HFD. LKB1-KO promoted anabolic signaling through increasing t-eIF2α and eIF4E expression, and promoted protein degradation through increasing protein ubiquitination. Because the degradation is the main effect and lead to muscle weight decrease. The effect of HFD and/or LKB1-KO on the LKB1-AMPK system was also determined. The results showed that knocking-out LKB1 decreased AMPK activity, decreased nuclear distribution for AMPK α2 and increased AMPK α1 expression. Long-term HFD increased t-AMPK expression in LKB1-KO mice, decreased the cytoplasm p-AMPK and nuclear p/t-AMPK ratio in CON mice. Together the findings of this dissertation demonstrated HFD induced glucose/insulin tolerance, while LKB1-KO had a controversial effect on glucose/insulin sensitivity. Both HFD and LKB1-KO affect AMPK expression and cellular location, while LKB1-KO also affects AMPK activity. LKB1-KO promoted protein degradation through ubiquitination in skeletal muscle.

Subjects/Keywords: high-fat diet; LKB1; skeletal muscle; AMPK; insulin/glucose tolerance test; GLUT4; Physiology

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APA (6^th Edition):

Chen, T. (2017). LKB1 Regulation of High-Fat Diet-induced Adaptation in Mouse Skeletal Muscle. (Doctoral Dissertation). Brigham Young University. Retrieved from https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7682&context=etd

Chicago Manual of Style (16^th Edition):

Chen, Ting. “LKB1 Regulation of High-Fat Diet-induced Adaptation in Mouse Skeletal Muscle.” 2017. Doctoral Dissertation, Brigham Young University. Accessed January 17, 2021. https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7682&context=etd.

MLA Handbook (7^th Edition):

Chen, Ting. “LKB1 Regulation of High-Fat Diet-induced Adaptation in Mouse Skeletal Muscle.” 2017. Web. 17 Jan 2021.

Vancouver:

Chen T. LKB1 Regulation of High-Fat Diet-induced Adaptation in Mouse Skeletal Muscle. [Internet] [Doctoral dissertation]. Brigham Young University; 2017. [cited 2021 Jan 17]. Available from: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7682&context=etd.

Council of Science Editors:

Chen T. LKB1 Regulation of High-Fat Diet-induced Adaptation in Mouse Skeletal Muscle. [Doctoral Dissertation]. Brigham Young University; 2017. Available from: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7682&context=etd

Univerzitet u Beogradu

15. Prodanović, Radiša, 1981-. Insulinska rezistencija kod krava Holštajn rase tokom perioda zasušenja i rane laktacije.

Degree: Fakultet veterinarske medicine, 2015, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:8045/bdef:Content/get

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Veterinarska medicina - Bolesti papkara / Veterinary Medicine - Ruminants and Swine Diseases

Cilj istraživanja u okviru ove disertacije je bio da se ispita da… (more)

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Veterinarska medicina - Bolesti papkara / Veterinary Medicine - Ruminants and Swine Diseases

Cilj istraživanja u okviru ove disertacije je bio da se ispita da li u periodu oko teljenja postoje razlike u stepenu insulinske rezistencije kod visokomlečnih krava različite telesne kondicije. U tu svrhu je, 30. dana pre očekivanog teljenja, odabrano 16 krava holštajn rase različite telesne kondicije. Prvu grupu (kontrolna, n = 8) činile su krave optimalne telesne kondicije (ОТК = 3,00 до 3,25), a drugu (ogledna, n = 8) ugojene životinje (ОТК = 4,25 до 4,50). Sve životinje uključene u ogled podvrgnute su intravenskom testu opterećenja glukozom (GTT) četiri puta: 28. i 10. dana pre očekivanog termina teljenja, kao i 14. i 28. dana posle teljenja. Uzorci krvi su uzimani neposredno (0. minut) pre aplikacije rastvora glukoze, kao i 15., 30., 60., 90., 120. i 180. minuta nakon davanja glukoze. U uzorcima uzetim 0. minuta određivane su koncentracije ukupnih proteina, albumina, BHBA, ukupnog bilirubina, uree, Ca i P, dok je u svim uzetim uzorcima krvi određivana koncentracija glukoze, insulina i NEFA. Deset dana pre, kao i 14. dana posle teljenja uzeti su uzorci tkiva jetre, masnog i mišićnog tkiva od svih ispitanih životinja. U uzorcima tkiva jetre određivan je stepen zamašćenja jetre, a u uzorcima masnog tkiva dijametar adipocita. Zastupljenost proteina receptora za insulin i transportnog molekula za glukozu (GLUT 4) ispitana je u mišićnom i masnom tkivu. Za procenu stepena insulinske rezistencije tokom izvođenja GTT korišćeni su matematički izvedeni parametri metabolizma glukoze (k, T1/2, Pikgluk i AUCgluk), insulina (ΔMaxins, Pikins i AUCins), NEFA (AUCNEFA), kao i RQUICKY indeks. Rezultati su pokazali da antepartalno nije bilo značajne razlike u vrednostima ispitivanih biohemijskih parametara između dve grupe krava, dok je postpartalno utvrđena značajno viša koncentracija ukupnog bilirubina (p < 0,05) 14. dana, a značajno niža koncentracija albumina (p < 0,05) 28. dana laktacije kod oglednih u odnosu na kontrolne krave. Rezultati dobijeni tokom izvođenja prvog GTT su pokazali da je glikemija bila značajno veća (p < 0,05) kod oglednih nego kontrolnih krava jedino 180. minuta, dok se koncentracije insulina i NEFA nisu značajno razlikovale između dve grupe krava...°

Advisors/Committee Members: Šamanc, Horea, 1948-.

Subjects/Keywords: high-yielding dairy cows; body condition; insulin resistance; glucose tolerance test; insulin receptor; GLUT 4

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Prodanović, Radiša, 1. (2015). Insulinska rezistencija kod krava Holštajn rase tokom perioda zasušenja i rane laktacije. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:8045/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Prodanović, Radiša, 1981-. “Insulinska rezistencija kod krava Holštajn rase tokom perioda zasušenja i rane laktacije.” 2015. Thesis, Univerzitet u Beogradu. Accessed January 17, 2021. https://fedorabg.bg.ac.rs/fedora/get/o:8045/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Prodanović, Radiša, 1981-. “Insulinska rezistencija kod krava Holštajn rase tokom perioda zasušenja i rane laktacije.” 2015. Web. 17 Jan 2021.

Vancouver:

Prodanović, Radiša 1. Insulinska rezistencija kod krava Holštajn rase tokom perioda zasušenja i rane laktacije. [Internet] [Thesis]. Univerzitet u Beogradu; 2015. [cited 2021 Jan 17]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:8045/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Prodanović, Radiša 1. Insulinska rezistencija kod krava Holštajn rase tokom perioda zasušenja i rane laktacije. [Thesis]. Univerzitet u Beogradu; 2015. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:8045/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Univerzitet u Beogradu

16. Kovačević, Gordana N., 1987-. Proteinski inženjering i razvoj visoko efikasnih metoda za pretraživanje biblioteke gena glukoza-oksidaze iz Aspergillus niger u cilju povećanja enzimske aktivnosti i stabilnosti.

Degree: Hemijski fakultet, 2019, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:19139/bdef:Content/get

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Hemija - Biohemija / Chemistry - Biochemistry

Glukoza-oksidaza (GOx) je vaţan industrijski enzim koji se predominantno koristi kao biokatalizator u industriji hrane za proizvodnju glukonske… (more)

Subjects/Keywords: glucose oxidase; high-throughput screening; oxidative stability; yeast surface display; green fluorescent protein; Pichia pastoris

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APA (6^th Edition):

Kovačević, Gordana N., 1. (2019). Proteinski inženjering i razvoj visoko efikasnih metoda za pretraživanje biblioteke gena glukoza-oksidaze iz Aspergillus niger u cilju povećanja enzimske aktivnosti i stabilnosti. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:19139/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kovačević, Gordana N., 1987-. “Proteinski inženjering i razvoj visoko efikasnih metoda za pretraživanje biblioteke gena glukoza-oksidaze iz Aspergillus niger u cilju povećanja enzimske aktivnosti i stabilnosti.” 2019. Thesis, Univerzitet u Beogradu. Accessed January 17, 2021. https://fedorabg.bg.ac.rs/fedora/get/o:19139/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kovačević, Gordana N., 1987-. “Proteinski inženjering i razvoj visoko efikasnih metoda za pretraživanje biblioteke gena glukoza-oksidaze iz Aspergillus niger u cilju povećanja enzimske aktivnosti i stabilnosti.” 2019. Web. 17 Jan 2021.

Vancouver:

Kovačević, Gordana N. 1. Proteinski inženjering i razvoj visoko efikasnih metoda za pretraživanje biblioteke gena glukoza-oksidaze iz Aspergillus niger u cilju povećanja enzimske aktivnosti i stabilnosti. [Internet] [Thesis]. Univerzitet u Beogradu; 2019. [cited 2021 Jan 17]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:19139/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kovačević, Gordana N. 1. Proteinski inženjering i razvoj visoko efikasnih metoda za pretraživanje biblioteke gena glukoza-oksidaze iz Aspergillus niger u cilju povećanja enzimske aktivnosti i stabilnosti. [Thesis]. Univerzitet u Beogradu; 2019. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:19139/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – San Francisco

17. Liang, Xiaomin. The Pharmacologic and Biologic Roles of Transporters for Metformin.

Degree: Pharmaceutical Sciences and Pharmacogenomics, 2016, University of California – San Francisco

URL: http://www.escholarship.org/uc/item/79x9t9ww

► Membrane transporters are widely expressed throughout the body, transporting nutrients, metabolites, toxins, and drugs across cellular membranes. In drug development, transporters are clinically important for… (more)

▼ Membrane transporters are widely expressed throughout the body, transporting nutrients, metabolites, toxins, and drugs across cellular membranes. In drug development, transporters are clinically important for drug absorption and disposition, and play significant roles in pharmacokinetics and treatment response. In addition, there is a growing interest in physiologic roles of transporters as polymorphisms in many drug transporters have been significantly associated with human diseases. Metformin is widely used as first-line treatment of type 2 diabetes. It exists primarily as a hydrophilic cation at physiological pHs, and therefore, membrane transporters are involved in its intestinal absorption, tissues distribution, and renal elimination. Multiple organic cation transporters play roles in the pharmacokinetics of metformin, and many of them play important roles in its pharmacological response, as mediators of metformin entry into target tissues. Here, we investigated transporters of metformin, with an emphasis on the pharmacological and biological roles of transporters in the intestine and liver. We characterized the human thiamine transporter (THTR-2; SLC19A3), which plays a major role in the intestinal absorption of thiamine (Vitamin B1). We found that human THTR-2 is capable of transporting other compounds including the drugs metformin and famotidine, and the neurotoxin MPP+. Other chemical agents including phenformin, chloroquine, verapamil, famotidine, amprolium, and pyrithiamine were inhibitors of hTHTR-2 mediated uptake of both thiamine and metformin. Interestingly, previous studies from our laboratory and others identified thiamine as an endogenous substrate for several organic cation transporters including OCT1, OCT2, and MATE1. In our second study, we focused on the endogenous role of OCT1, which is the major hepatic transporter for metformin. Through extensive experiments in Oct1 knockout mice, our data support the notion that hepatic thiamine deficiency is the underlying mechanism for the clinical phenotypes associated with reduced OCT1 function, particularly elevated LDL- cholesterol and total cholesterol levels. Our data suggest that reduced OCT1-mediated thiamine uptake in the liver leads to reduced levels of thiamine pyrophosphate, TPP, and a decreased activity of key TPP-dependent enzymes. As a result, there is a shift from glucose to fatty acid oxidation in the liver, which disrupts key metabolic flux pathways. In parallel, through analysis of published genomewide association studies, we show that reduced function OCT1 polymorphisms are associated with several metabolic traits in humans. Taken together, our studies suggest that changes in OCT1 activity modulate the disposition of thiamine and its active metabolite, TPP, which results in alterations in hepatic energy metabolism, ultimately affecting total body energy homeostasis. Finally, we developed a comparative structural model of OCT1 that discriminates ligands from non-ligands and is the model together with an in vitro high-throughput screening…

Subjects/Keywords: Pharmacology; Glucose metabolism; High-throughput screening; Metformin; OCT1; Organic cation transporters; Thiamine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Liang, X. (2016). The Pharmacologic and Biologic Roles of Transporters for Metformin. (Thesis). University of California – San Francisco. Retrieved from http://www.escholarship.org/uc/item/79x9t9ww

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Liang, Xiaomin. “The Pharmacologic and Biologic Roles of Transporters for Metformin.” 2016. Thesis, University of California – San Francisco. Accessed January 17, 2021. http://www.escholarship.org/uc/item/79x9t9ww.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Liang, Xiaomin. “The Pharmacologic and Biologic Roles of Transporters for Metformin.” 2016. Web. 17 Jan 2021.

Vancouver:

Liang X. The Pharmacologic and Biologic Roles of Transporters for Metformin. [Internet] [Thesis]. University of California – San Francisco; 2016. [cited 2021 Jan 17]. Available from: http://www.escholarship.org/uc/item/79x9t9ww.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Liang X. The Pharmacologic and Biologic Roles of Transporters for Metformin. [Thesis]. University of California – San Francisco; 2016. Available from: http://www.escholarship.org/uc/item/79x9t9ww

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

18. Frick, Hannah. The Effect of an Acute Bout of Exercise on Postprandial Metabolic Responses in Younger and Older Adults.

Degree: 2019, James Madison University

URL: https://commons.lib.jmu.edu/master201019/638

► Over 370,000 Americans, primarily between the ages of 60 and 79, die annually as a result of cardiovascular disease caused by physical inactivity and a… (more)

▼ Over 370,000 Americans, primarily between the ages of 60 and 79, die annually as a result of cardiovascular disease caused by physical inactivity and a diet that is calorically dense and high in fat. Current findings in young and middle-aged adults suggest that acute exercise with energy expenditure in excess of 500 kcals, may attenuate the deleterious health effects caused by consuming the typical American meal. Purpose:The purpose of this study was to examine the effects of acute exercise and aging on postprandial lipemia (PPL) and postprandial glycemia (PPG). We hypothesized that aerobic exercise performed prior to the consumption of a high-fat meal will attenuate PPL and PPG in younger and older adults. Methods: 12 younger adults (Y: 20-32 yrs) and 12 older adults (O: 61-77 yrs) completed an exercise test to determine peak oxygen consumption (VO2peak). On two separate occasions subjects consumed a high fat meal (HFM) consisting of 12 kcals/kg bodyweight. Blood samples were collected at 30-minute intervals over a 6-hour period to determine postprandial triglycerides, cholesterol, and glucose. Twelve hours prior to one of the HFM challenges, subjects exercised on a cycle ergometer at 65% VO2peakto expend 75% of the kilocalories they would be consuming in the HFM the next day. Results:There was a significant main effect for time for PPTG where PPTG levels increased postprandially (p < 0.001), regardless of exercise condition. There was a significant time x condition interaction for glucose where acute exercise significantly attenuated PPG in Y, but not in O (p = 0.041). There was no significant main effect for time for total cholesterol (p = 0.082). There were no time x age x condition interactions for any measures. Conclusions: The difference in time to peak PPTG in O suggests that an acute exercise session performed prior to consuming a HFM can help to shorten the duration that older adults experience elevated plasma triglycerides after a high fat meal. The reduction in PPG in Y but not in O suggests that in healthy older individuals, aging may reduce the impact of acute exercise on PPG. Advisors/Committee Members: Elizabeth S. Edwards, Stephanie P. Kurti, Nicholas D. Luden.

Subjects/Keywords: postprandial; acute exercise; high fat meal; triglycerides; glucose; older adults; Exercise Science; Kinesiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Frick, H. (2019). The Effect of an Acute Bout of Exercise on Postprandial Metabolic Responses in Younger and Older Adults. (Masters Thesis). James Madison University. Retrieved from https://commons.lib.jmu.edu/master201019/638

Chicago Manual of Style (16^th Edition):

Frick, Hannah. “The Effect of an Acute Bout of Exercise on Postprandial Metabolic Responses in Younger and Older Adults.” 2019. Masters Thesis, James Madison University. Accessed January 17, 2021. https://commons.lib.jmu.edu/master201019/638.

MLA Handbook (7^th Edition):

Frick, Hannah. “The Effect of an Acute Bout of Exercise on Postprandial Metabolic Responses in Younger and Older Adults.” 2019. Web. 17 Jan 2021.

Vancouver:

Frick H. The Effect of an Acute Bout of Exercise on Postprandial Metabolic Responses in Younger and Older Adults. [Internet] [Masters thesis]. James Madison University; 2019. [cited 2021 Jan 17]. Available from: https://commons.lib.jmu.edu/master201019/638.

Council of Science Editors:

Frick H. The Effect of an Acute Bout of Exercise on Postprandial Metabolic Responses in Younger and Older Adults. [Masters Thesis]. James Madison University; 2019. Available from: https://commons.lib.jmu.edu/master201019/638

York University

19. Uthayakumar, Abinas. The Effect of High-Fat Diet and Exercise on Non-Alcoholic Fatty Liver Disease and Glycemic Control.

Degree: MSc -MS, Kinesiology & Health Science, 2015, York University

URL: http://hdl.handle.net/10315/30735

► This study investigates the effects of chronic high-fat diet (HFD) and endurance training on Non-Alcoholic Fatty Liver Disease (NAFLD) and glycemic control. Here we report… (more)

Subjects/Keywords: Kinesiology; Physiology; obesity; exercise; high-fat diet; hepatic glucose production; gluconeogenesis; glycogen synthesis; hepatic steatosis; non-alcoholic fatty liver disease; insulin resistance; lipogenesis; liver; lipid oxidation; chronic endurance training; glucose 6-phosphate; glucose; metabolism; glucose tolerance test; pyruvate tolerance test; insulin signalling; diabetes; NAFLD

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Uthayakumar, A. (2015). The Effect of High-Fat Diet and Exercise on Non-Alcoholic Fatty Liver Disease and Glycemic Control. (Masters Thesis). York University. Retrieved from http://hdl.handle.net/10315/30735

Chicago Manual of Style (16^th Edition):

Uthayakumar, Abinas. “The Effect of High-Fat Diet and Exercise on Non-Alcoholic Fatty Liver Disease and Glycemic Control.” 2015. Masters Thesis, York University. Accessed January 17, 2021. http://hdl.handle.net/10315/30735.

MLA Handbook (7^th Edition):

Uthayakumar, Abinas. “The Effect of High-Fat Diet and Exercise on Non-Alcoholic Fatty Liver Disease and Glycemic Control.” 2015. Web. 17 Jan 2021.

Vancouver:

Uthayakumar A. The Effect of High-Fat Diet and Exercise on Non-Alcoholic Fatty Liver Disease and Glycemic Control. [Internet] [Masters thesis]. York University; 2015. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10315/30735.

Council of Science Editors:

Uthayakumar A. The Effect of High-Fat Diet and Exercise on Non-Alcoholic Fatty Liver Disease and Glycemic Control. [Masters Thesis]. York University; 2015. Available from: http://hdl.handle.net/10315/30735

20. Nguyen, Phuong Nga. Caractérisation de la fonction vasculaire dans les vaisseaux sanguins isolés en réponse au glucose élevé et de l'artère mammaire interne de patients diabétiques : Characterization of vascular function of isolated blood vessels in response to high glucose and internal mammary artery from diabetic patients.

Degree: Docteur es, Pharmacologie cardiovasculaire, 2017, Université de Strasbourg

URL: http://www.theses.fr/2017STRAJ004

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D’abord, nous avons visé à établir un modèle ex vivo de la dysfonction endothéliale induite par le glucose élevé (HG) dans les artères isolées de… (more)

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D’abord, nous avons visé à établir un modèle ex vivo de la dysfonction endothéliale induite par le glucose élevé (HG) dans les artères isolées de rat Wistar mâle et porc. Notre but était de clarifier le rôle des SGLT1/2 dans les cellules endothéliales dans les conditions HG pour évaluer l'effet protecteur des gliflozines sur la fonction endothéliale. Cependant, HG n'a pas affecté la relaxation dépendant de l'endothélium. L'absence d'effet d’HG pourrait être liée aux facteurs, tels que les conditions d'incubation, le genre, l'âge, la souche, l’espèce d'animal et les conditions de logement. Enfin, nous avons caractérisé les artères mammaires internes humaines (AMI) de 58 patients ayant subi un pontage coronarien au Nouvel Hôpital Civil de Strasbourg. Nous avons trouvé l'association du diabète et de l'hypertension au niveau accru du stress oxydatif dans les AMI humaines. Les niveaux d'expression de la eNOS, des SGLT et du système d’angiotensine local doivent être étudiés plus en détail.

Firstly, we aimed to establish an ex vivo model of high glucose (HG)-induced endothelial dysfunction in isolated arteries from male Wistar rat and porc. Then, our goal was to clarify the contribution of SGLT1/2 in endothelial cells under HG conditions to evaluate the protective effect of gliflozins on the endothelial function. However, HG did not affect the endothelium-dependent relaxation response in all tested types of artery. The lack of effect of HG might be related to certain factors, such as the incubation conditions, gender, age, strain, species of studied animals, and conditions of housing of animals. Secondly, we characterized human internal mammary arteries (IMA) of 58 patients underwent coronary artery bypass grafting in the New Civil Hospital of Strasbourg. We found the association of diabetes and hypertension in the enhanced level of oxidative stress in human IMA. The expression levels of eNOS, SGLTs and the components of angiotensin system need to be further investigated.

Advisors/Committee Members: Schini-Kerth, Valérie (thesis director).

Subjects/Keywords: Glucose élevé; Dysfonction endothéliale; Stress oxydatif; SGLT; Artères mammaires internes humaines; High glucose; Endothelial dysfunction; Oxidative stress; Human internal mammary arteries; 615.7; 616.13

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nguyen, P. N. (2017). Caractérisation de la fonction vasculaire dans les vaisseaux sanguins isolés en réponse au glucose élevé et de l'artère mammaire interne de patients diabétiques : Characterization of vascular function of isolated blood vessels in response to high glucose and internal mammary artery from diabetic patients. (Doctoral Dissertation). Université de Strasbourg. Retrieved from http://www.theses.fr/2017STRAJ004

Chicago Manual of Style (16^th Edition):

Nguyen, Phuong Nga. “Caractérisation de la fonction vasculaire dans les vaisseaux sanguins isolés en réponse au glucose élevé et de l'artère mammaire interne de patients diabétiques : Characterization of vascular function of isolated blood vessels in response to high glucose and internal mammary artery from diabetic patients.” 2017. Doctoral Dissertation, Université de Strasbourg. Accessed January 17, 2021. http://www.theses.fr/2017STRAJ004.

MLA Handbook (7^th Edition):

Nguyen, Phuong Nga. “Caractérisation de la fonction vasculaire dans les vaisseaux sanguins isolés en réponse au glucose élevé et de l'artère mammaire interne de patients diabétiques : Characterization of vascular function of isolated blood vessels in response to high glucose and internal mammary artery from diabetic patients.” 2017. Web. 17 Jan 2021.

Vancouver:

Nguyen PN. Caractérisation de la fonction vasculaire dans les vaisseaux sanguins isolés en réponse au glucose élevé et de l'artère mammaire interne de patients diabétiques : Characterization of vascular function of isolated blood vessels in response to high glucose and internal mammary artery from diabetic patients. [Internet] [Doctoral dissertation]. Université de Strasbourg; 2017. [cited 2021 Jan 17]. Available from: http://www.theses.fr/2017STRAJ004.

Council of Science Editors:

Nguyen PN. Caractérisation de la fonction vasculaire dans les vaisseaux sanguins isolés en réponse au glucose élevé et de l'artère mammaire interne de patients diabétiques : Characterization of vascular function of isolated blood vessels in response to high glucose and internal mammary artery from diabetic patients. [Doctoral Dissertation]. Université de Strasbourg; 2017. Available from: http://www.theses.fr/2017STRAJ004

University of Exeter

21. Cruz, A. M. The integrated physiology of glucose homeostasis : regulation by extracellular and intracellular nucleotide sensors.

Degree: PhD, 2020, University of Exeter

URL: http://hdl.handle.net/10871/120731

► Physiological glucose levels are maintained by the complex integration of neuroendocrine, hormonal and nutritional signals controlled by multiple tissues in the body. A dysregulation in… (more)

▼ Physiological glucose levels are maintained by the complex integration of neuroendocrine, hormonal and nutritional signals controlled by multiple tissues in the body. A dysregulation in these mechanisms leads to increasingly prevalent conditions characterised by an inability to regulate blood glucose levels, such as diabetes. Maintaining glycaemia within a target range remains a daily challenge for individuals with both Type 1 and Type 2 diabetes and a better understanding of the pathophysiology of impaired glucose homeostasis in these conditions is still required to identify more effective and targeted therapeutic approaches. Work in this thesis focused on elucidating the mechanisms by which lipid overflow, be it from increasingly sedentary behaviour or overfeeding, leads to the development of insulin and anabolic resistance in skeletal muscle. Loss of insulin-stimulated glucose clearance by skeletal muscle is a main driver for impaired glucose disposal in Type 2 diabetes and a role for excessive lipid availability in this pathology is well established. Here, muscle cells were treated with high concentrations of a saturated fatty acid and data demonstrated that lipid overflow led to impaired anabolic sensitivity, inflammatory cytokine release and mitochondrial dysfunction. Furthermore, these experiments elucidated a novel role for adenosine tri-phosphate, acting as a signalling molecule, in the regulation of muscle glucose metabolism, identifying insulin and exercise mimetic roles of the nucleotide that could be therapeutically targetable. This work was translated into humans, where the effect of lipid overflow by high-fat overfeeding was assessed in an experimental model of inactivity-induced insulin and anabolic resistance. Data suggested that two days of disuse (by forearm immobilisation) were sufficient to cause substantial muscle insulin resistance. After 7 days, muscle strength was significantly reduced and anabolic resistance was evident due to decreased forearm balance of potent anabolic amino acids such as leucine. Contrary to the hypothesis, high-fat overfeeding did not accelerate or exacerbate these impairments, suggesting that removal of contraction represents a potent stimulus for loss of substrate demand by muscle, irrespective of energy balance. Insulin replacement therapy has been the cornerstone of treatment for Type 1 and advanced Type 2 diabetes for over 8 decades. A serious and inadvertent consequence of prolonged insulin therapy is the increased risk of hypoglycaemia. Hypoglycaemia can lead to impaired physiological defences against a decrease in blood glucose and loss of awareness of these changes. AMP-activated protein kinase activators, which are widely used (to target peripheral tissues) as anti-hyperglycaemic agents in Type 2 diabetes have demonstrated central effects that amplify the first defence against hypoglycaemia, or counterregulatory response. Data presented here demonstrated that peripheral administration of a brain permeable AMP-activated protein kinase activator amplified the…

Subjects/Keywords: Glucose homeostasis; Nucleotides; Skeletal muscle; Diabetes; Hypoglycaemia; AMPK; High-fat diet; Lipid; Palmitate; C2C12 myotubes; Sprague-Dawley rats; Glucose clamp; Nucleotide sensor; ATP

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cruz, A. M. (2020). The integrated physiology of glucose homeostasis : regulation by extracellular and intracellular nucleotide sensors. (Doctoral Dissertation). University of Exeter. Retrieved from http://hdl.handle.net/10871/120731

Chicago Manual of Style (16^th Edition):

Cruz, A M. “The integrated physiology of glucose homeostasis : regulation by extracellular and intracellular nucleotide sensors.” 2020. Doctoral Dissertation, University of Exeter. Accessed January 17, 2021. http://hdl.handle.net/10871/120731.

MLA Handbook (7^th Edition):

Cruz, A M. “The integrated physiology of glucose homeostasis : regulation by extracellular and intracellular nucleotide sensors.” 2020. Web. 17 Jan 2021.

Vancouver:

Cruz AM. The integrated physiology of glucose homeostasis : regulation by extracellular and intracellular nucleotide sensors. [Internet] [Doctoral dissertation]. University of Exeter; 2020. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10871/120731.

Council of Science Editors:

Cruz AM. The integrated physiology of glucose homeostasis : regulation by extracellular and intracellular nucleotide sensors. [Doctoral Dissertation]. University of Exeter; 2020. Available from: http://hdl.handle.net/10871/120731

Michigan State University

22. Campbell, Barbara Baker. Effect of dietary fiber on glucose tolerance in rats.

Degree: PhD, Department of Food Science and Human Nutrition, 1984, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:29103

Subjects/Keywords: Fiber in animal nutrition; Glucose tolerance tests; High-fiber diet; Glucose; Rats – Physiology

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APA (6^th Edition):

Campbell, B. B. (1984). Effect of dietary fiber on glucose tolerance in rats. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:29103

Chicago Manual of Style (16^th Edition):

Campbell, Barbara Baker. “Effect of dietary fiber on glucose tolerance in rats.” 1984. Doctoral Dissertation, Michigan State University. Accessed January 17, 2021. http://etd.lib.msu.edu/islandora/object/etd:29103.

MLA Handbook (7^th Edition):

Campbell, Barbara Baker. “Effect of dietary fiber on glucose tolerance in rats.” 1984. Web. 17 Jan 2021.

Vancouver:

Campbell BB. Effect of dietary fiber on glucose tolerance in rats. [Internet] [Doctoral dissertation]. Michigan State University; 1984. [cited 2021 Jan 17]. Available from: http://etd.lib.msu.edu/islandora/object/etd:29103.

Council of Science Editors:

Campbell BB. Effect of dietary fiber on glucose tolerance in rats. [Doctoral Dissertation]. Michigan State University; 1984. Available from: http://etd.lib.msu.edu/islandora/object/etd:29103

RMIT University

23. Almrhag, O. Structural studies of biopolymers/co-solute interactions in high-solid preparations.

Degree: 2012, RMIT University

URL: http://researchbank.rmit.edu.au/view/rmit:160135

► High-solid biomaterials increasingly include a number of non-starchy polysaccharides, i.e dietary fibre to deliver a range of properties such as structure, storage stability, processability, etc.… (more)

▼ High-solid biomaterials increasingly include a number of non-starchy polysaccharides, i.e dietary fibre to deliver a range of properties such as structure, storage stability, processability, etc. The first type of high-solid biomaterials analysed this Thesis consists of agarose and co-solute (polydextrose), with the investigation dealing with changes in network morphology of agarose when mixed with polydextrose from low to high-solid preparations. There was a central observation of decline in the mechanical strength of aqueous agarose preparation upon addition of high levels of polydextrose, which was accompanied by a reduced enthalpic content of the coil-to-helix transition in the polysaccharide network. Glass transition phenomena were observed at subzero temperatures in condensed preparations, hence further arguing for the formation of a lightly cross-linked agarose network with changing solvent quality. The second system consists of high methoxy pectin and co-solute in the form of polydextrose or glucose syrup, with a view to examining the potential of replacing sugar with polydextrose in commercial formulations. Structural properties of pectin preparations were recorded in relation to the molecular weight and concentration of added co-solute in an acidic environment (pH ~ 3.0). High levels of co-solute induce formation of weak pectin gels at elevated temperatures (even at 95Â°C), which upon subsequent cooling exhibit increasing strength and convert to a clear glass at subzero temperatures. Glucose syrup is an efficient plasticiser leading to a reduction in the glass transition temperature of the pectin network, whereas polydextrose assists in the formation of stronger pectin gels in the rubbery state and accelerated vitrification properties. The investigation on the third system, gelatin and polydextrose as the co-solute, focused on the understanding of structural behaviour in the presence of the non-sugar co-solute and in comparison with polysaccharides. A progression in the mechanical strength and thermal stability of the gelatin network was observed with the addition of polydextrose to the system, which was distinct from that of polysaccharide/co-systems. Combined thermomechanical and microscopy evidence argues for the development of phase separation phenomenon between protein and co-solute in high-solid preparations, where gelatin maintains helical conformation to provide network integrity as well as glassy consistency at subzero temperature. Again, that was distinct from the state of a single-phase system and â€œmolecular dissolutionâ€ of polysaccharides in a high-content co-solute environment. At the high solids regime, glassy consistency was treated with theoretical frameworks from the synthetic polymer research to pinpoint the glass transition temperature of the gelatin/co-solute preparation. The fourth system consisting of agarose, gelatin, and co-solute (polydextrose) was investigated from low to high levels of total solids, with a view to examining the phase behaviour of binary biopolymer mixtures…

Subjects/Keywords: Fields of Research; Polydextrose; glucose syrup; gelatin; high methoxy pectin; agarose; rheology; calorimetry; FTIR; microscopy; X-ray

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APA (6^th Edition):

Almrhag, O. (2012). Structural studies of biopolymers/co-solute interactions in high-solid preparations. (Thesis). RMIT University. Retrieved from http://researchbank.rmit.edu.au/view/rmit:160135

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Almrhag, O. “Structural studies of biopolymers/co-solute interactions in high-solid preparations.” 2012. Thesis, RMIT University. Accessed January 17, 2021. http://researchbank.rmit.edu.au/view/rmit:160135.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Almrhag, O. “Structural studies of biopolymers/co-solute interactions in high-solid preparations.” 2012. Web. 17 Jan 2021.

Vancouver:

Almrhag O. Structural studies of biopolymers/co-solute interactions in high-solid preparations. [Internet] [Thesis]. RMIT University; 2012. [cited 2021 Jan 17]. Available from: http://researchbank.rmit.edu.au/view/rmit:160135.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Almrhag O. Structural studies of biopolymers/co-solute interactions in high-solid preparations. [Thesis]. RMIT University; 2012. Available from: http://researchbank.rmit.edu.au/view/rmit:160135

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

24. Pataky, Mark. Mechanisms for Exercise, High-Fat Diet, and Muscle Fiber-Type Effects on Insulin-Stimulated Glucose Uptake in Skeletal Muscle.

Degree: PhD, Kinesiology, 2019, University of Michigan

URL: http://hdl.handle.net/2027.42/151424

► Insulin resistance of skeletal muscle, a tissue which accounts for up to 85% of insulin-mediated glucose disposal, is a primary and essential precursor that leads… (more)

▼ Insulin resistance of skeletal muscle, a tissue which accounts for up to 85% of insulin-mediated glucose disposal, is a primary and essential precursor that leads to type 2 diabetes. A single bout of exercise can subsequently enhance insulin-stimulated glucose uptake (ISGU) in insulin-resistant skeletal muscle. Although much work has been performed in healthy muscle, the mechanisms which lead to increased post-exercise insulin sensitivity in insulin-resistant muscle are far less understood. Therefore, the main objective of this dissertation was to provide insights into the mechanisms for enhanced post-exercise ISGU in muscle from insulin-resistant rats. Further complicating our understanding of post-exercise insulin sensitivity is the fact that skeletal muscle is a heterogeneous tissue composed of multiple fiber types with varied metabolic properties. Therefore, research in this thesis exploited the metabolic heterogeneity of different fiber types to investigate potential mechanisms for enhanced post-exercise ISGU in insulin-resistant muscle at a cellular level. Study 1 revealed that a 2-week high-fat diet (HFD), which causes whole muscle insulin resistance, results in fiber type-specific decrements in ISGU. Study 2 uncovered that acute exercise by HFD-fed rats results in increased ISGU of all type II fiber types (including IIB, IIBX, IIX, IIAX, and IIA), but ISGU was unaltered post-exercise in type I fibers, the only fiber type to maintain normal insulin sensitivity on a HFD. The striking fiber type-specific results of both a HFD and of acute exercise on ISGU revealed a need to better understand mechanisms for enhanced post-exercise ISGU at a cellular level. Studies 3 and 4 assessed key post-exercise signaling events in whole muscle and different fiber types, respectively, from HFD-fed rats. The results from insulin-resistant whole muscle tissue support the concept that increased γ3-AMPK activity is an important post-exercise event which eventually leads to enhanced insulin-stimulated AS160 phosphorylation. Further, the results revealed that fiber type-specific insulin-stimulated AS160 phosphorylation was site-specific. The fiber type-specific AS160 phosphorylation in Study 4 roughly corresponded with the observed fiber type-specific ISGU in Study 2. Therefore, these results support the idea, at least in some fiber types from insulin-resistant muscle, that AS160 plays a key role in mediating enhanced post-exercise ISGU. Further studies are warranted to assess the direct effect of site-specific AS160 phosphorylation and γ3-AMPK activity on post-exercise ISGU. A better understanding of the mechanisms for enhanced ISGU following exercise in insulin-resistant skeletal muscle will facilitate the development and implementation of novel therapies and interventions to mitigate the deleterious effects of insulin resistance. Advisors/Committee Members: Cartee, Gregory Dean (committee member), Bridges, Dave (committee member), Horowitz, Jeffrey F (committee member), Mendias, Christopher Louis (committee member).

Subjects/Keywords: exercise; muscle fiber type; insulin-stimulated glucose uptake; skeletal muscle; high-fat diet; insulin signaling; Kinesiology and Sports; Health Sciences

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APA (6^th Edition):

Pataky, M. (2019). Mechanisms for Exercise, High-Fat Diet, and Muscle Fiber-Type Effects on Insulin-Stimulated Glucose Uptake in Skeletal Muscle. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/151424

Chicago Manual of Style (16^th Edition):

Pataky, Mark. “Mechanisms for Exercise, High-Fat Diet, and Muscle Fiber-Type Effects on Insulin-Stimulated Glucose Uptake in Skeletal Muscle.” 2019. Doctoral Dissertation, University of Michigan. Accessed January 17, 2021. http://hdl.handle.net/2027.42/151424.

MLA Handbook (7^th Edition):

Pataky, Mark. “Mechanisms for Exercise, High-Fat Diet, and Muscle Fiber-Type Effects on Insulin-Stimulated Glucose Uptake in Skeletal Muscle.” 2019. Web. 17 Jan 2021.

Vancouver:

Pataky M. Mechanisms for Exercise, High-Fat Diet, and Muscle Fiber-Type Effects on Insulin-Stimulated Glucose Uptake in Skeletal Muscle. [Internet] [Doctoral dissertation]. University of Michigan; 2019. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/2027.42/151424.

Council of Science Editors:

Pataky M. Mechanisms for Exercise, High-Fat Diet, and Muscle Fiber-Type Effects on Insulin-Stimulated Glucose Uptake in Skeletal Muscle. [Doctoral Dissertation]. University of Michigan; 2019. Available from: http://hdl.handle.net/2027.42/151424

Penn State University

25. Troy, Amanda Erin. Diet-induced modulation of vagal sensory signaling.

Degree: 2014, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/23416

► As obesity levels continue to rise in developed nations, it becomes increasingly important to determine the mechanisms underlying obesity. Ingested food induces the release of… (more)

▼ As obesity levels continue to rise in developed nations, it becomes increasingly important to determine the mechanisms underlying obesity. Ingested food induces the release of various neurohormones and neuropeptides, such as 5-HT, that activate the sensory vagus, which then relays the signal to the brain. These vagally-mediated satiety signals are capable of a substantial amount plasticity and modulation in response to physiological demands. The present work will investigate the effects of high fat diet (HFD) exposure on the ability of glucose to modulate the 5-HT-induced response of gastric projecting vagal afferent neurons. In response to changing circulating glucose levels, vagal afferent neurons are able to alter their membrane-associated 5-HT3 receptor profile and afferent nerve function centrally at the level of the nucleus of the tractus solitaries and peripherally at the level of the nodose ganglion. In several peripheral and central tissues, protein kinase C (PKC) activity is correlated with glucose level and, in the present study, the glucose-dependent modulation of 5-HT3 receptor density and function appears to be mediated via a PKC and/or PKC pathway. The rapid timescale of electrophysiological effects suggest that glucose may modulate vagal sensory signaling on a minute-to-minute basis. Therefore, by regulating the number of functional 5-HT3 receptors associated with the membrane of gastric vagal afferent neurons, extracellular glucose is able to adapt its own ‘perception’, allowing for amplification and prolongation of its own signaling. While exposure to a HFD does not affect either the proportion of gastric vagal afferent neurons that respond to 5-HT, or the magnitude of the 5-HT-induced response, the ability of glucose to modulate 5-HT3 receptor density and function is disrupted, even after relatively short periods of HFD exposure, well in advance of the development of obesity or dysregulation of blood glucose levels, suggesting that diet may profoundly affect vagal afferent responsiveness independent of obesity. While short periods of HFD exposure disrupt and attenuate the ability of glucose to modulate 5-HT-mediated vagal signaling, restoration of a normal diet permits recovery although the time-scale for recovery appears to be much longer than that required to induce the initial reduced sensitivity. This provides additional support for the concept that vago-vagal neurocircuits are sensitive to diet-induced modulation and adaptation. Furthermore, the reversibility of the adverse effects of HFD exposure suggests that peripheral vagal afferents may be a more readily accessible and attractive target for obesity research, potentially opening the door to new treatment options and preventative techniques. Advisors/Committee Members: Kirsteen Nairn Browning, Dissertation Advisor/Co-Advisor, Gregory Michael Holmes, Committee Member, Andras Hajnal, Committee Member, Patricia Mc Laughlin, Committee Member, Ann Ouyang, Committee Chair/Co-Chair.

Subjects/Keywords: vagus; vagal afferent; 5-HT; glucose; high fat diet; protein kinase C; electrophysiology; immunocytochemistry; 5-HT3 receptor

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APA (6^th Edition):

Troy, A. E. (2014). Diet-induced modulation of vagal sensory signaling. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/23416

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Troy, Amanda Erin. “Diet-induced modulation of vagal sensory signaling.” 2014. Thesis, Penn State University. Accessed January 17, 2021. https://submit-etda.libraries.psu.edu/catalog/23416.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Troy, Amanda Erin. “Diet-induced modulation of vagal sensory signaling.” 2014. Web. 17 Jan 2021.

Vancouver:

Troy AE. Diet-induced modulation of vagal sensory signaling. [Internet] [Thesis]. Penn State University; 2014. [cited 2021 Jan 17]. Available from: https://submit-etda.libraries.psu.edu/catalog/23416.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Troy AE. Diet-induced modulation of vagal sensory signaling. [Thesis]. Penn State University; 2014. Available from: https://submit-etda.libraries.psu.edu/catalog/23416

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

26. Turner, Maddison. The Effects of High Glucose Exposure on Endothelial Microparticles .

Degree: 2017, University of Ottawa

URL: http://hdl.handle.net/10393/36660

► Individuals with diabetes have an increased mortality due to the macro- and microvascular complications, which are commonly preceded by endothelial dysfunction. We have shown that… (more)

▼ Individuals with diabetes have an increased mortality due to the macro- and microvascular complications, which are commonly preceded by endothelial dysfunction. We have shown that endothelial microparticles (eMPs) are markers and mediators of vascular injury and pathology. However, their utility as a biomarker of hyperglycemia-induced endothelial damage and their influence on the vasculature remains unclear. We hypothesized that high glucose (HG) exposure alters eMPs protein composition, making them reflective of active signalling processes characteristic of a hyperglycemic environment. In addition, HG alters eMPs bioactivity, making them more potent inducers of oxidative stress, thrombosis and endothelial damage. Therefore, we assessed the exclusive effects of HG on eMPs formation, composition, and signalling. Results: Exposure of endothelial cells to high glucose for 24 hours caused a 3-fold increase in eMPs formation, increased mean vesicle size and their absolute electronegativity. Proteomic analysis of eMPs identified 1,212 independent proteins, with 68 exclusive to HG and associated with signalling processes related to metabolic processes, oxidation-reduction reactions, hemostasis and thrombosis and cellular interactions at the vascular wall. Compared to eMPs formed under normal conditions, eMPs formed in response to HG possess a ~3-fold greater procoagulant activity, induced a greater production of cellular ROS and were more potent inhibitors of endothelial-dependent relaxation. Conclusions/Interpretation: Taken together our results indicate HG alters the composition of eMPs, making them more potent mediators of endothelial damage. With similar changes in bioactivity being evident in the protein composition and the associated enriched biological processes, eMPs protein content may provide insight into the pathophysiological status of the cells in a hyperglycemic environment and provide use clinically, to identify dysregulated pathways for therapeutic targeting.

Subjects/Keywords: Microparticles; Extracellular Vesicles; High Glucose; Endothelial Dysfunction

…High Glucose) eMPs Cultured in 25mM L-Glucose (Osmotic Control) eMPs Cultured… …Endothelial Cells High D-Glucose Human Microvascular Endothelial Cells High Performance Liquid… …Munkonda MN., Akbari S., & K.D. Burns. (2017). High glucose increases the formation and… …resulting in impaired glucose uptake and high circulating levels of glucose. 1.1.2. Insulin… …high glucose levels, glycolytic mechanisms cannot compensate for the intense influx. Excess…

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APA (6^th Edition):

Turner, M. (2017). The Effects of High Glucose Exposure on Endothelial Microparticles . (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/36660

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Turner, Maddison. “The Effects of High Glucose Exposure on Endothelial Microparticles .” 2017. Thesis, University of Ottawa. Accessed January 17, 2021. http://hdl.handle.net/10393/36660.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Turner, Maddison. “The Effects of High Glucose Exposure on Endothelial Microparticles .” 2017. Web. 17 Jan 2021.

Vancouver:

Turner M. The Effects of High Glucose Exposure on Endothelial Microparticles . [Internet] [Thesis]. University of Ottawa; 2017. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10393/36660.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Turner M. The Effects of High Glucose Exposure on Endothelial Microparticles . [Thesis]. University of Ottawa; 2017. Available from: http://hdl.handle.net/10393/36660

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Nova

27. Mata, Ana Cristina Dias da. The agroindustrial residue valorisation with high pressure CO2 within biorefinery concept.

Degree: 2014, Universidade Nova

URL: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/12165

Dissertação para obtenção do Grau de Mestre em Engenharia Química e Bioquímica Advisors/Committee Members: Bogel-Lukasik, Rafal.

Subjects/Keywords: High pressure; Xylo-oligosaccharides; Enzymatic hydrolysis; Glucose; Wheat straw

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APA (6^th Edition):

Mata, A. C. D. d. (2014). The agroindustrial residue valorisation with high pressure CO2 within biorefinery concept. (Thesis). Universidade Nova. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/12165

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mata, Ana Cristina Dias da. “The agroindustrial residue valorisation with high pressure CO2 within biorefinery concept.” 2014. Thesis, Universidade Nova. Accessed January 17, 2021. http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/12165.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mata, Ana Cristina Dias da. “The agroindustrial residue valorisation with high pressure CO2 within biorefinery concept.” 2014. Web. 17 Jan 2021.

Vancouver:

Mata ACDd. The agroindustrial residue valorisation with high pressure CO2 within biorefinery concept. [Internet] [Thesis]. Universidade Nova; 2014. [cited 2021 Jan 17]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/12165.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mata ACDd. The agroindustrial residue valorisation with high pressure CO2 within biorefinery concept. [Thesis]. Universidade Nova; 2014. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/12165

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Connecticut

28. Novak, Marc J. Chemically Modified Proteins as Highly Stable Building Blocks For Functional Bionanomaterials.

Degree: MS, Molecular and Cell Biology, 2014, University of Connecticut

URL: https://opencommons.uconn.edu/gs_theses/597

► Enzymes are key molecular machines that catalyze biologically important chemical reactions. The use of these powerful catalysts has recently been investigated for more industrial… (more)

Subjects/Keywords: glucose oxidase; chemical modification; graphene oxide; bio-hybrid; stability; half-life; high temperature; circular dicroism; activity

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APA (6^th Edition):

Novak, M. J. (2014). Chemically Modified Proteins as Highly Stable Building Blocks For Functional Bionanomaterials. (Masters Thesis). University of Connecticut. Retrieved from https://opencommons.uconn.edu/gs_theses/597

Chicago Manual of Style (16^th Edition):

Novak, Marc J. “Chemically Modified Proteins as Highly Stable Building Blocks For Functional Bionanomaterials.” 2014. Masters Thesis, University of Connecticut. Accessed January 17, 2021. https://opencommons.uconn.edu/gs_theses/597.

MLA Handbook (7^th Edition):

Novak, Marc J. “Chemically Modified Proteins as Highly Stable Building Blocks For Functional Bionanomaterials.” 2014. Web. 17 Jan 2021.

Vancouver:

Novak MJ. Chemically Modified Proteins as Highly Stable Building Blocks For Functional Bionanomaterials. [Internet] [Masters thesis]. University of Connecticut; 2014. [cited 2021 Jan 17]. Available from: https://opencommons.uconn.edu/gs_theses/597.

Council of Science Editors:

Novak MJ. Chemically Modified Proteins as Highly Stable Building Blocks For Functional Bionanomaterials. [Masters Thesis]. University of Connecticut; 2014. Available from: https://opencommons.uconn.edu/gs_theses/597

University of Manchester

29. Namvar, Sara. Investigating the role of corticosterone in meal anticipatory behaviour, metabolism and glucosetolerance.

Degree: 2011, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:103865

► Daily rhythms in physiology and behaviour are orchestrated by theautonomously rhythmic cells of the suprachiasmatic nucleus (SCN).Restricting food intake to the rest phase of nocturnal… (more)

▼ Daily rhythms in physiology and behaviour are orchestrated by theautonomously rhythmic cells of the suprachiasmatic nucleus (SCN).Restricting food intake to the rest phase of nocturnal rodents, leads to thedevelopment of meal anticipatory behaviour, corticosterone and bodytemperature. Given that lesions to the SCN fail to abolish meal anticipation, asecond oscillator of unknown location, referred to as the food-entrainableoscillator (FEO) is thought to exist. Although the site of the FEO is unknown,several hypothalamus nuclei, including the dorsomedial hypothalamus(DMH) are thought to play a role in meal anticipation. Given thatadrenalectomy is reported to abolish meal anticipation, an intact HPA axis isalso thought to contribute to the functioning of the FEO. Some forms ofobesity are characterised by high basal levels of circulating corticosterone. Inaddition, limited access to high fat diet, fails to induce the development ofrobust meal anticipation in rats.During our initial studies, the effect of a standard and 45% high fat diet onthe development of meal anticipatory behaviour and hypothalamic c-Fosexpression were investigated. Restricted access to high fat diet led toattenuation of meal anticipation compared to those fed standard diet. Thiswas concurrent with a failure to develop an anticipatory rise in DMH c-Fosexpression. A meal anticipatory rise in corticosterone is thought to benecessary for the presence of meal anticipation as well as adaptation ofmetabolism to daily restricted feeding. In the next set of studies, weconfirmed that restricted access to standard diet leads to the development ofa meal anticipatory rise in plasma corticosterone. In contrast we observed adramatic post-anticipatory rise in plasma corticosterone in rats givenrestricted access to the 45% high fat diet. We hypothesised that the highcorticosterone levels resulting from high fat diet were a contributing factor tothe lack of meal anticipation in high fat fed rats. With the aid of apharmacokinetic study, a suitable experiment was designed for daily dosingof a potent glucocorticoid receptor antagonist, RU486, with the aim ofrescuing meal anticipation in high fat fed rats. Interestingly, treatment withRU486 successfully rescued meal anticipation in high fat fed rats, butattenuated meal anticipation in standard diet restricted fed rats. In the finalseries of studies the effect of diet and feeding regime on glucose toleranceand metabolism were investigated. High fat feeding was found to reduceglucose tolerance in both ad lib and restricted fed rats, with RU486 treatmentimproving glucose tolerance in a time dependant manner. Restricted accessto food was found to induce post satiation lipogenesis in both standard dietfed and to a lesser extent in high fat fed rats, an effect which may bebeneficial in reducing obesity. Overall the results provide further insight intothe complex role of corticosterone in promoting or preventing mealanticipatory behaviour. An anticipatory rise in plasma corticosterone isrequired for meal anticipation, as… Advisors/Committee Members: Piggins, Hugh.

Subjects/Keywords: Circadian; hypothalamus; Food entrainable oscillator; Meal anticipation; Corticosterone; glucose tolerance; RU486; HPA axis; High fat feeding

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APA (6^th Edition):

Namvar, S. (2011). Investigating the role of corticosterone in meal anticipatory behaviour, metabolism and glucosetolerance. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:103865

Chicago Manual of Style (16^th Edition):

Namvar, Sara. “Investigating the role of corticosterone in meal anticipatory behaviour, metabolism and glucosetolerance.” 2011. Doctoral Dissertation, University of Manchester. Accessed January 17, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:103865.

MLA Handbook (7^th Edition):

Namvar, Sara. “Investigating the role of corticosterone in meal anticipatory behaviour, metabolism and glucosetolerance.” 2011. Web. 17 Jan 2021.

Vancouver:

Namvar S. Investigating the role of corticosterone in meal anticipatory behaviour, metabolism and glucosetolerance. [Internet] [Doctoral dissertation]. University of Manchester; 2011. [cited 2021 Jan 17]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:103865.

Council of Science Editors:

Namvar S. Investigating the role of corticosterone in meal anticipatory behaviour, metabolism and glucosetolerance. [Doctoral Dissertation]. University of Manchester; 2011. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:103865

University of Adelaide

30. Schelbach, Cheryl J. An investigation into the effect of glucosamine on reproductive outcomes in the mouse.

Degree: 2012, University of Adelaide

URL: http://hdl.handle.net/2440/83569

► It is well established that conditions experienced in utero by the developing fetus can elicit permanent effects on the post natal period. Although not as… (more)

▼ It is well established that conditions experienced in utero by the developing fetus can elicit permanent effects on the post natal period. Although not as well understood, a growing body of research also suggests that this can also occur in response to peri-conceptional insult. Glucosamine (GlcN) is a popular dietary supplement that is also used experimentally as a hyperglycaemic mimetic. The work contained in this thesis tests the hypothesis that pre and peri-conceptional exposure to GlcN has adverse effects on reproductive outcomes in the mouse. Preliminary experiments (Chapter 2) confirmed that the inclusion of GlcN into the in vitro maturation (IVM) media used for mouse cumulus oocyte complex (COC) maturation, reduced oocyte developmental potential. Subsequent experiments (Chapter 3) demonstrated that the inhibition of O-linked glycosylation of unknown proteins reversed the effects of GlcN. It was also shown that GlcN exposure during IVM altered Pentose phosphate pathway (PPP) activity within the oocyte. As predicted, preliminary in vivo experiments performed in Chapter 4 showed that maternal, peri-conceptional GlcN administration compromised fetal development. This was seen by a decreased mean implantation rate and litter size as well as an increase in the proportion of fetal resorptions on gestational day 18 (d18), and provided the impetus to examine the in vivo effects of GlcN exposure more carefully. It was subsequently hypothesized that these adverse effects would be heightened if given to mice with overweight-induced metabolic pathologies. In contrast to Chapter 4 outcomes, GlcN elicited no effects on d18 implantation, resorption or litter size parameters, but did reduce fetal weight. Furthermore, birth defects were higher in mice given GlcN and maintained on a low fat (LF) diet. An additional cohort of mice was allowed to give birth, and offspring were assessed for 16 weeks. There was an unexpectedly high death rate in the offspring of mice maintained on a high fat (HF) diet but not given GlcN, therefore preventing optimally controlled post natal analyses to occur. Of the remaining mice, a number of physiological differences were detected within GlcN-exposed groups. Since the principle difference between mice in Chapters 4 and 5 was maternal age, an addition experiment investigating the effects of peri-conceptional GlcN exposure in 8 week and 16 week old mice was undertaken (Chapter 6). Consistent with previous results, GlcN treatment reduced mean implantation rate and litter size only in 8 week old mice and reduced fetal weigh and length solely in 16 week old mice. Increased birth defects were also detected in the HF group given GlcN. Collectively these results provide important insights into the importance of optimal conditions during the peri-conceptional period to facilitate successful subsequent development. They also provide evidence that GlcN is a simple but effective tool that can be used to further elucidate the impact of hyperglycaemic exposure during the early developmental period. This is of… Advisors/Committee Members: Thompson, Jeremy Gilbert E. (advisor), Kind, Karen Lee (advisor), School of Paediatrics and Reproductive Health (school).

Subjects/Keywords: glucosamine; COC; embryo; high fat diet; hyperglycaemia; glucose; HBP; PPP; mouse; IVM; embryo culture; peri-conceptional; reproductive outcomes

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APA (6^th Edition):

Schelbach, C. J. (2012). An investigation into the effect of glucosamine on reproductive outcomes in the mouse. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/83569

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Schelbach, Cheryl J. “An investigation into the effect of glucosamine on reproductive outcomes in the mouse.” 2012. Thesis, University of Adelaide. Accessed January 17, 2021. http://hdl.handle.net/2440/83569.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Schelbach, Cheryl J. “An investigation into the effect of glucosamine on reproductive outcomes in the mouse.” 2012. Web. 17 Jan 2021.

Vancouver:

Schelbach CJ. An investigation into the effect of glucosamine on reproductive outcomes in the mouse. [Internet] [Thesis]. University of Adelaide; 2012. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/2440/83569.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Schelbach CJ. An investigation into the effect of glucosamine on reproductive outcomes in the mouse. [Thesis]. University of Adelaide; 2012. Available from: http://hdl.handle.net/2440/83569

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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