subject:(high cholesterol)

University of Illinois – Chicago

1. Guadamuz, Jenny. Use of Antihyperlipidemics among Adults with Cardiovascular Disease in the US and England from 2003-2012.

Degree: 2017, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/22082

► Antihyperlipidemics are proven effective for the secondary prevention of cardiovascular disease (CVD). Comparative analysis on the prevalence of antihyperlipidemic use for secondary prevention of CVD… (more)

Subjects/Keywords: high cholesterol; statins; use of medicines

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APA (6^th Edition):

Guadamuz, J. (2017). Use of Antihyperlipidemics among Adults with Cardiovascular Disease in the US and England from 2003-2012. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/22082

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Guadamuz, Jenny. “Use of Antihyperlipidemics among Adults with Cardiovascular Disease in the US and England from 2003-2012.” 2017. Thesis, University of Illinois – Chicago. Accessed January 24, 2021. http://hdl.handle.net/10027/22082.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Guadamuz, Jenny. “Use of Antihyperlipidemics among Adults with Cardiovascular Disease in the US and England from 2003-2012.” 2017. Web. 24 Jan 2021.

Vancouver:

Guadamuz J. Use of Antihyperlipidemics among Adults with Cardiovascular Disease in the US and England from 2003-2012. [Internet] [Thesis]. University of Illinois – Chicago; 2017. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/10027/22082.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Guadamuz J. Use of Antihyperlipidemics among Adults with Cardiovascular Disease in the US and England from 2003-2012. [Thesis]. University of Illinois – Chicago; 2017. Available from: http://hdl.handle.net/10027/22082

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Gomes, Ana Lúcia Flora Santos. A Saliva como potencial meio de diagnóstico.

Degree: 2015, RCAAP

URL: https://www.rcaap.pt/detail.jsp?id=oai:repositorio.cespu.pt:20.500.11816/2625

► Os múltiplos constituintes salivares podem ser utilizados como biomarcadores de doenças e condições sistémicas do indivíduo. A natureza não invasiva da colheita da saliva é… (more)

▼ Os múltiplos constituintes salivares podem ser utilizados como biomarcadores de doenças e condições sistémicas do indivíduo. A natureza não invasiva da colheita da saliva é atrativa como método alternativo ao usado para o sangue. Alguns analitos são difíceis de detetar devido à sua baixa concentração na saliva. Este estudo tem como objetivo avaliar a correlação entre os níveis de PCR de alta sensibilidade (asPCR), Colesterol total, Colesterol LDL, Colesterol HDL, Triglicerídeos, Ácido Úrico e Ureia em amostras de saliva e sangue, assegurando a reprodutibilidade dos métodos. Participaram neste estudo 42 indivíduos saudáveis (21 do sexo masculino e 21 do sexo feminino). As metodologias utilizadas foram: o método enzimático colorimétrico (colesterol total, colesterol LDL, colesterol HDL, triglicerídeos e ácido úrico), método UV cinético (ureia) e nefelometria (asPCR). Os valores de concentração do colesterol total, colesterol LDL, colesterol HDL, triglicerídeos e asPCR foram inferiores ao limite de deteção do método. Na determinação quantitativa do ácido úrico e ureia observaram-se diferenças estatisticamente significativas (p<0,05), entre o soro e a saliva. A concentração de ácido úrico obtida na saliva resultou numa mediana 2,0 (Percentil 25-75; 1,2-2,4) mg/dL, sendo inferior à verificada no soro, 4,7 (4,0-5,2) mg/dL. Contrariamente, a concentração da ureia na saliva, com mediana de 35 (27-48) mg/dL, foi superior à verificada no soro 28 (26-32) mg/dL. Obteve-se uma correlação positiva fraca no ácido úrico (rs=0,16) e ureia (r2=0,40) , entre a saliva e o soro. O uso da saliva como meio de diagnóstico, é promissora para aplicação clínica, podendo este estudo contribuir para este propósito, juntamente com outros com maior numero de amostras, com valores de referência e curvas de calibração adaptados e que simultaneamente garantam a reprodutibilidade dos métodos. Advisors/Committee Members: Farinha, Rui Miguel Ribeiro Barbosa.

Subjects/Keywords: Saliva; Venous blood; Total cholesterol; LDL cholesterol; HDL cholesterol; Triglycerides; High senditive C-reactive protein (hs-CRP); Uric acid and urea

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APA (6^th Edition):

Gomes, A. L. F. S. (2015). A Saliva como potencial meio de diagnóstico. (Thesis). RCAAP. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:repositorio.cespu.pt:20.500.11816/2625

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gomes, Ana Lúcia Flora Santos. “A Saliva como potencial meio de diagnóstico.” 2015. Thesis, RCAAP. Accessed January 24, 2021. https://www.rcaap.pt/detail.jsp?id=oai:repositorio.cespu.pt:20.500.11816/2625.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gomes, Ana Lúcia Flora Santos. “A Saliva como potencial meio de diagnóstico.” 2015. Web. 24 Jan 2021.

Vancouver:

Gomes ALFS. A Saliva como potencial meio de diagnóstico. [Internet] [Thesis]. RCAAP; 2015. [cited 2021 Jan 24]. Available from: https://www.rcaap.pt/detail.jsp?id=oai:repositorio.cespu.pt:20.500.11816/2625.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gomes ALFS. A Saliva como potencial meio de diagnóstico. [Thesis]. RCAAP; 2015. Available from: https://www.rcaap.pt/detail.jsp?id=oai:repositorio.cespu.pt:20.500.11816/2625

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Gupta, Dinesh. Evaluation of a Hypolipidaemic/Cardioprotective drug of dabur india limited in treatment of Hyperlipidaemia; -.

Degree: Medicine, 1993, Bundelkhand University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/11514

None

Bibliography p. 87-99, Appendices p. 100-111

Advisors/Committee Members: Agarwal, Navnit, Arora, R C, Arora, Sunita.

Subjects/Keywords: Cardioprotective; Medicine; Hyperlipidaemia; High Cholesterol

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APA (6^th Edition):

Gupta, D. (1993). Evaluation of a Hypolipidaemic/Cardioprotective drug of dabur india limited in treatment of Hyperlipidaemia; -. (Thesis). Bundelkhand University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/11514

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gupta, Dinesh. “Evaluation of a Hypolipidaemic/Cardioprotective drug of dabur india limited in treatment of Hyperlipidaemia; -.” 1993. Thesis, Bundelkhand University. Accessed January 24, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/11514.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gupta, Dinesh. “Evaluation of a Hypolipidaemic/Cardioprotective drug of dabur india limited in treatment of Hyperlipidaemia; -.” 1993. Web. 24 Jan 2021.

Vancouver:

Gupta D. Evaluation of a Hypolipidaemic/Cardioprotective drug of dabur india limited in treatment of Hyperlipidaemia; -. [Internet] [Thesis]. Bundelkhand University; 1993. [cited 2021 Jan 24]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/11514.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gupta D. Evaluation of a Hypolipidaemic/Cardioprotective drug of dabur india limited in treatment of Hyperlipidaemia; -. [Thesis]. Bundelkhand University; 1993. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/11514

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

4. Bashiri, Amir. Cholesterol Plays a Crucial Role in High-fat-diet Induced ER stress and Non-alcoholic Fatty Liver Disease.

Degree: 2014, University of Toronto

URL: http://hdl.handle.net/1807/74632

►

By comparing C57 mice with two dyslipidemic models, LDL-receptor null (LDLR-/-) and LCAT/LDL-receptor null mice (LCAT-/-xLDLR-/-), our lab showed an observation of ER-membrane cholesterol being… (more)

Subjects/Keywords: Cholesterol; ER-stress; High fat diet; Murine; NAFLD/NASH; Obesity; 0719

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APA (6^th Edition):

Bashiri, A. (2014). Cholesterol Plays a Crucial Role in High-fat-diet Induced ER stress and Non-alcoholic Fatty Liver Disease. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/74632

Chicago Manual of Style (16^th Edition):

Bashiri, Amir. “Cholesterol Plays a Crucial Role in High-fat-diet Induced ER stress and Non-alcoholic Fatty Liver Disease.” 2014. Masters Thesis, University of Toronto. Accessed January 24, 2021. http://hdl.handle.net/1807/74632.

MLA Handbook (7^th Edition):

Bashiri, Amir. “Cholesterol Plays a Crucial Role in High-fat-diet Induced ER stress and Non-alcoholic Fatty Liver Disease.” 2014. Web. 24 Jan 2021.

Vancouver:

Bashiri A. Cholesterol Plays a Crucial Role in High-fat-diet Induced ER stress and Non-alcoholic Fatty Liver Disease. [Internet] [Masters thesis]. University of Toronto; 2014. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/1807/74632.

Council of Science Editors:

Bashiri A. Cholesterol Plays a Crucial Role in High-fat-diet Induced ER stress and Non-alcoholic Fatty Liver Disease. [Masters Thesis]. University of Toronto; 2014. Available from: http://hdl.handle.net/1807/74632

5. Hirano, Masatoshi. Low high density lipoprotein cholesterol level is a significant risk factor for development of type 2 diabetes : Data from the Hawaii-Los Angeles-Hiroshima study : 低HDLコレステロール値は、2型糖尿病発症の危険因子である : ハワイ・ロサンゼルス・広島スタディより.

Degree: 博士(医学), 2014, Hiroshima University / 広島大学

URL: http://ir.lib.hiroshima-u.ac.jp/00036282

► Aims/Introduction: A low level of high-density lipoprotein cholesterol (HDLC) is a common feature of metabolic syndrome. We have reported that Japanese-Americans who share a virtually… (more)

Subjects/Keywords: High-density lipoprotein cholesterol; Type 2 diabetes; Westernized lifestyle

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APA (6^th Edition):

Hirano, M. (2014). Low high density lipoprotein cholesterol level is a significant risk factor for development of type 2 diabetes : Data from the Hawaii-Los Angeles-Hiroshima study : 低HDLコレステロール値は、2型糖尿病発症の危険因子である : ハワイ・ロサンゼルス・広島スタディより. (Thesis). Hiroshima University / 広島大学. Retrieved from http://ir.lib.hiroshima-u.ac.jp/00036282

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hirano, Masatoshi. “Low high density lipoprotein cholesterol level is a significant risk factor for development of type 2 diabetes : Data from the Hawaii-Los Angeles-Hiroshima study : 低HDLコレステロール値は、2型糖尿病発症の危険因子である : ハワイ・ロサンゼルス・広島スタディより.” 2014. Thesis, Hiroshima University / 広島大学. Accessed January 24, 2021. http://ir.lib.hiroshima-u.ac.jp/00036282.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hirano, Masatoshi. “Low high density lipoprotein cholesterol level is a significant risk factor for development of type 2 diabetes : Data from the Hawaii-Los Angeles-Hiroshima study : 低HDLコレステロール値は、2型糖尿病発症の危険因子である : ハワイ・ロサンゼルス・広島スタディより.” 2014. Web. 24 Jan 2021.

Vancouver:

Hirano M. Low high density lipoprotein cholesterol level is a significant risk factor for development of type 2 diabetes : Data from the Hawaii-Los Angeles-Hiroshima study : 低HDLコレステロール値は、2型糖尿病発症の危険因子である : ハワイ・ロサンゼルス・広島スタディより. [Internet] [Thesis]. Hiroshima University / 広島大学; 2014. [cited 2021 Jan 24]. Available from: http://ir.lib.hiroshima-u.ac.jp/00036282.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hirano M. Low high density lipoprotein cholesterol level is a significant risk factor for development of type 2 diabetes : Data from the Hawaii-Los Angeles-Hiroshima study : 低HDLコレステロール値は、2型糖尿病発症の危険因子である : ハワイ・ロサンゼルス・広島スタディより. [Thesis]. Hiroshima University / 広島大学; 2014. Available from: http://ir.lib.hiroshima-u.ac.jp/00036282

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Columbia University

6. Lee, Samuel. Insulin Regulation of Reverse Cholesterol Transport.

Degree: 2019, Columbia University

URL: https://doi.org/10.7916/d8-yzmw-9347

► Insulin resistance and type 2 diabetes are pathogenetically linked to increased risk of cardiovascular disease. While insulin resistance is defined by a dysregulation in hepatic… (more)

Subjects/Keywords: Nutrition; Biology; High density lipoproteins – Metabolism; Insulin resistance; Cholesterol

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APA (6^th Edition):

Lee, S. (2019). Insulin Regulation of Reverse Cholesterol Transport. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/d8-yzmw-9347

Chicago Manual of Style (16^th Edition):

Lee, Samuel. “Insulin Regulation of Reverse Cholesterol Transport.” 2019. Doctoral Dissertation, Columbia University. Accessed January 24, 2021. https://doi.org/10.7916/d8-yzmw-9347.

MLA Handbook (7^th Edition):

Lee, Samuel. “Insulin Regulation of Reverse Cholesterol Transport.” 2019. Web. 24 Jan 2021.

Vancouver:

Lee S. Insulin Regulation of Reverse Cholesterol Transport. [Internet] [Doctoral dissertation]. Columbia University; 2019. [cited 2021 Jan 24]. Available from: https://doi.org/10.7916/d8-yzmw-9347.

Council of Science Editors:

Lee S. Insulin Regulation of Reverse Cholesterol Transport. [Doctoral Dissertation]. Columbia University; 2019. Available from: https://doi.org/10.7916/d8-yzmw-9347

East Carolina University

7. Yaeger, Michael. A NOVEL ROLE FOR HDL AND D-HDL IN PULMONARY IMMUNITY.

Degree: MS, MS-Biomedical Engineering, 2018, East Carolina University

URL: http://hdl.handle.net/10342/6943

► Cardiovascular and pulmonary diseases are leading causes of morbidity and mortality worldwide. Studies report an inverse correlation between levels of serum high-density lipoprotein (HDL) and… (more)

Subjects/Keywords: HDL; LPS; Pulmonary; Dysfunctional HDL; Cholesterol; High density lipoproteins; Heart – Diseases

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APA (6^th Edition):

Yaeger, M. (2018). A NOVEL ROLE FOR HDL AND D-HDL IN PULMONARY IMMUNITY. (Masters Thesis). East Carolina University. Retrieved from http://hdl.handle.net/10342/6943

Chicago Manual of Style (16^th Edition):

Yaeger, Michael. “A NOVEL ROLE FOR HDL AND D-HDL IN PULMONARY IMMUNITY.” 2018. Masters Thesis, East Carolina University. Accessed January 24, 2021. http://hdl.handle.net/10342/6943.

MLA Handbook (7^th Edition):

Yaeger, Michael. “A NOVEL ROLE FOR HDL AND D-HDL IN PULMONARY IMMUNITY.” 2018. Web. 24 Jan 2021.

Vancouver:

Yaeger M. A NOVEL ROLE FOR HDL AND D-HDL IN PULMONARY IMMUNITY. [Internet] [Masters thesis]. East Carolina University; 2018. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/10342/6943.

Council of Science Editors:

Yaeger M. A NOVEL ROLE FOR HDL AND D-HDL IN PULMONARY IMMUNITY. [Masters Thesis]. East Carolina University; 2018. Available from: http://hdl.handle.net/10342/6943

Georgia State University

8. Smith, Morgan. The Association Between a History of Prior Experience with Meditation and the Prevalence of Chronic Health Conditions: Evidence from the 2012 NHIS.

Degree: MPH, Public Health, 2017, Georgia State University

URL: https://scholarworks.gsu.edu/iph_theses/489

► The use of Complementary and Alternative Medicine (CAM) has grown in popularity since the 1990’s. One possible explanation is the Western medicine’s inability to… (more)

Subjects/Keywords: Meditation; Chronic Health; Hypertension; Diabetes; High Cholesterol; BMI

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APA (6^th Edition):

Smith, M. (2017). The Association Between a History of Prior Experience with Meditation and the Prevalence of Chronic Health Conditions: Evidence from the 2012 NHIS. (Thesis). Georgia State University. Retrieved from https://scholarworks.gsu.edu/iph_theses/489

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Smith, Morgan. “The Association Between a History of Prior Experience with Meditation and the Prevalence of Chronic Health Conditions: Evidence from the 2012 NHIS.” 2017. Thesis, Georgia State University. Accessed January 24, 2021. https://scholarworks.gsu.edu/iph_theses/489.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Smith, Morgan. “The Association Between a History of Prior Experience with Meditation and the Prevalence of Chronic Health Conditions: Evidence from the 2012 NHIS.” 2017. Web. 24 Jan 2021.

Vancouver:

Smith M. The Association Between a History of Prior Experience with Meditation and the Prevalence of Chronic Health Conditions: Evidence from the 2012 NHIS. [Internet] [Thesis]. Georgia State University; 2017. [cited 2021 Jan 24]. Available from: https://scholarworks.gsu.edu/iph_theses/489.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Smith M. The Association Between a History of Prior Experience with Meditation and the Prevalence of Chronic Health Conditions: Evidence from the 2012 NHIS. [Thesis]. Georgia State University; 2017. Available from: https://scholarworks.gsu.edu/iph_theses/489

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cincinnati

9. Phetteplace, Janel E. Familial Hypercholesterolemia: Characterization of a pediatric population and evaluation of parental knowledge and attitudes.

Degree: MS, Medicine: Genetic Counseling, 2015, University of Cincinnati

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427813032

► Background: Familial Hypercholesterolemia (FH) is estimated to affect one in every five hundred people. FH is a lifelong condition that if untreated can lead to… (more)

▼ Background: Familial Hypercholesterolemia (FH) is estimated to affect one in every five hundred people. FH is a lifelong condition that if untreated can lead to premature coronary heart disease (CHD) and possibly death. In spite of the high prevalence, internationally FH is both underdiagnosed and undertreated, leaving a large population of people at a greatly increased risk for premature CHD. There are effective treatments available that can significantly improve long term survival. Methods: The prevalence of FH at CCHMC for individuals between age 2 and 21 was calculated using i2b2, a research data warehouse at CCHMC. A chart review was completed on 180 patients who were seen between 1/1/2011 and 7/15/2013 at CCHMC and met the inclusion criteria. A 42 item survey was developed to evaluate parental knowledge, attitudes and interest in genetic counseling and genetic testing. 171 surveys were sent out, 86 included an educational brochure created by the FH Foundation and 85 did not include the brochure. Results: The prevalence of FH in the selected population was 0.04%. 1% of individuals between the ages of 9 and 11 received cholesterol screening at CCHMC. Of the 180 individuals included in the chart review, 146 (81%) had seen a lipid specialist, 47 (26%) had a diagnosis of FH, 105 (58%) had a diagnosis of dyslipidemia or hyperlipidemia, 28 (16%) had been prescribed a statin, 0 (0%) had discussed FH with a genetic counselor. Of the 171 surveys sent, 76 surveys were completed with a response rate of 44%. Respondents whose child had been prescribed a statin had a higher mean knowledge score than respondents who children had not been prescribed a statin (p = 0.0267). If the respondent reported that a healthcare provider had talked to them about FH there was a trend towards significant associated with knowledge score (p = 0.0606). Receiving the educational brochure, having a diagnosis of FH, reported use of the internet to look up FH, annual house hold income and a reported family history of hypercholesterolemia were not associated with increased knowledge. Conclusions: Results from this study supports existing data regarding the under diagnosis of FH and the lack of adherence to routine cholesterol screening. Participants who reported a health care provider had previously spoken to them about FH were more knowledgeable compared to those who had not. Given the important role healthcare providers play in patient education, incorporating genetic counselors into the counseling and risk assessment of these patients and families may increase overall disease knowledge as well as adherence to cholesterol screening and genetic testing guidelines. Advisors/Committee Members: Urbina, Elaine (Committee Chair).

Subjects/Keywords: Genetics; Familial hypercholesterolemia; high cholesterol; dyslipidemia; parental attitudes; genetic counseling; knowledge

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APA (6^th Edition):

Phetteplace, J. E. (2015). Familial Hypercholesterolemia: Characterization of a pediatric population and evaluation of parental knowledge and attitudes. (Masters Thesis). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427813032

Chicago Manual of Style (16^th Edition):

Phetteplace, Janel E. “Familial Hypercholesterolemia: Characterization of a pediatric population and evaluation of parental knowledge and attitudes.” 2015. Masters Thesis, University of Cincinnati. Accessed January 24, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427813032.

MLA Handbook (7^th Edition):

Phetteplace, Janel E. “Familial Hypercholesterolemia: Characterization of a pediatric population and evaluation of parental knowledge and attitudes.” 2015. Web. 24 Jan 2021.

Vancouver:

Phetteplace JE. Familial Hypercholesterolemia: Characterization of a pediatric population and evaluation of parental knowledge and attitudes. [Internet] [Masters thesis]. University of Cincinnati; 2015. [cited 2021 Jan 24]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427813032.

Council of Science Editors:

Phetteplace JE. Familial Hypercholesterolemia: Characterization of a pediatric population and evaluation of parental knowledge and attitudes. [Masters Thesis]. University of Cincinnati; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427813032

10. Cooke, Allison L, B.A. The Molecular Interaction of Apolipoprotein A-I and Lecithin: Cholesterol Acyl Transferase.

Degree: PhD, Medicine: Pathobiology and Molecular Medicine, 2018, University of Cincinnati

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1543580636448357

► Background: Atherosclerosis is a multifactorial inflammatory disease that begins with the accumulation of lipid in arterial endothelium. Atherosclerosis is the leading cause of deaths attributable… (more)

▼ Background: Atherosclerosis is a multifactorial inflammatory disease that begins with the accumulation of lipid in arterial endothelium. Atherosclerosis is the leading cause of deaths attributable to cardiovascular disease in the United States. Epidemiological studies showing high-density lipoprotein (HDL) cholesterol is inversely correlated with atherosclerosis has made it a pharmacological target for preventing cardiovascular disease. However, outcomes from clinical trials have raised questions about HDL’s protective properties. Investigating the molecular interactions of apolipoprotein (apo)A-I, which accounts for approximately 70% of total HDL protein, can help translate HDL structure to cardioprotective function. Lecithin: cholesterol acyl transferase (LCAT) is a critical HDL-modifying protein that performs a key function in reverse cholesterol transport by using apoA-I as a cofactor to esterify cholesterol. Data from our lab and others demonstrate that apoA-I molecules dimerize into an antiparallel stacked ring-structure that encapsulates lipid in reconstituted (r)HDL. Cross-linking analysis of rHDL implies that apoA-I molecules exist in at least two distinct organizations: one with helix 5 of an apoA-I molecule adjacent to helix 5 of its antiparallel partner (5/5 helical registry), and the other in a 5/2 registry. We hypothesized that the orientation of apoA-I molecules on rHDL modulates LCAT activity. Objective: Identify the mechanism by which apoA-I activates LCAT to determine how HDL interacts with its immense proteome. Linking HDL structure and function will allow for therapeutic development that targets HDL-associated inflammatory diseases. Major Findings: 1)Antiparallel apoA-I molecules adopt a thumbwheel mechanism to generate a discontinuous epitope for LCAT activation. Site-directed cysteine mutagenesis was used to “lock” two apoA-I molecules into an antiparallel 5/5, 5/2, and 5/1 helical registry on rHDL. The 5/5 mutant demonstrated higher LCAT activity than wildtype (WT) rHDL, while the 5/2 and 5/1 mutants showed dramatically lower LCAT activity (p<0.001). Surface plasmon resonance (SPR) analysis revealed no differences in the binding affinity of LCAT to rHDL mutants versus WT. Chemical cross-linking of LCAT and WT rHDL resulted in identification of intermolecular interaction sites between K240 of LCAT and helices (H)4-H7 of apoA-I. We propose that LCAT binds to rHDL particles of comparable size and lipid composition, but is activated by a discontinuous epitope comprised of two antiparallel apoA-I molecules operating in a thumbwheel mechanism on rHDL. Altering the 5/5 registry disrupts this epitope and prevents LCAT activation. These studies provide a basis for understanding how apoA-I structure may modulate the association and activity of HDL associated-proteins. 2)Helix-helix cooperation in antiparallel apoA-I molecules is essential for LCAT activation. Point-mutations in H3 and H4 of apoA-I inhibited LCAT activation to the same extent as point-mutations in H6 and H7 (p<0.001). Potential… Advisors/Committee Members: Davidson, William Sean (Committee Chair).

Subjects/Keywords: Pathology; apolipoprotein A-I; LCAT; high density lipoprotein; subspecies; cholesterol; atherosclerosis

10 more images…

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APA (6^th Edition):

Cooke, Allison L, B. A. (2018). The Molecular Interaction of Apolipoprotein A-I and Lecithin: Cholesterol Acyl Transferase. (Doctoral Dissertation). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1543580636448357

Chicago Manual of Style (16^th Edition):

Cooke, Allison L, B A. “The Molecular Interaction of Apolipoprotein A-I and Lecithin: Cholesterol Acyl Transferase.” 2018. Doctoral Dissertation, University of Cincinnati. Accessed January 24, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1543580636448357.

MLA Handbook (7^th Edition):

Cooke, Allison L, B A. “The Molecular Interaction of Apolipoprotein A-I and Lecithin: Cholesterol Acyl Transferase.” 2018. Web. 24 Jan 2021.

Vancouver:

Cooke, Allison L BA. The Molecular Interaction of Apolipoprotein A-I and Lecithin: Cholesterol Acyl Transferase. [Internet] [Doctoral dissertation]. University of Cincinnati; 2018. [cited 2021 Jan 24]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1543580636448357.

Council of Science Editors:

Cooke, Allison L BA. The Molecular Interaction of Apolipoprotein A-I and Lecithin: Cholesterol Acyl Transferase. [Doctoral Dissertation]. University of Cincinnati; 2018. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1543580636448357

11. Paulo Wharton Negri. PREVALÊNCIA DOS FATORES DE RISCO PARA DOENÇAS CARDIOVASCULARES ENTRE TRABALHADORES ADMINISTRATIVOS DA COMPANHIA DE SANEAMENTO DO ESTADO DE GOIÁS S/A.

Degree: 2008, Universidade Católica de Goiás

URL: http://tede.biblioteca.ucg.br/tde_busca/arquivo.php?codArquivo=531

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The impact of non-transmissible chronic diseases in the population has been growing worldwide and creating serious problems of public health. The purpose of this study… (more)

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The impact of non-transmissible chronic diseases in the population has been growing worldwide and creating serious problems of public health. The purpose of this study was to identify the prevalence of the risk factors to cardiac disease and to analyze the association between these risk factors to cardiac disease. Three hundred and five employees of the administrative area of Companhia de Saneamento do Estado de Goiás were examined. The data was undertaken between September and November 2007 through form and blood sample. Identification and measurable data like weight, height, body mass index, and blood pressure were obtained during the form application. After the form application, blood was collected to analyze glucose and total cholesterol. The majority of the 305 participants were male. Most of the males had between 50 and 60 year-old and most of the females had between 40 and 50 year-old. There was no significant statistic difference in the education level between gender. The total prevalence of hypertension was 30,8%. It increased according to the age and was more common in males. The total obesity prevalence was 18,7%. It was also more frequent in males. The bigger prevalence of obesity was between 20 and 40 years (23,4%) and older than 60 years (23,5%). The prevalence of high cholesterol was elevated (60,0%), and more common in males. There was no difference in the cholesterol medium rates in both sexes. The prevalence of high glicemia was prominent (20,3%) and more frequent in males. The glicemia was higher in older people, especially after 50 year-old. The estimated risk of an obese person to have hypertension was 4,675. The estimated risk of a hypertension individual to have high cholesterol and elevated glicemia was bigger than normal one. The prevalence of hypertension was high in obese male group. Analysis by multiple logistic regression demonstrated the correlation between hypertension, obesity and sex. It is recommended to include in the company health programs to the employees paying special attention to those with risk factors to well established cardiac disease. Moreover, programs of prevention should also be done to minimize the prevalence of risk factors to cardiac diseases.

O impacto das doenças crônicas não-transmissíveis na saúde das populações é crescente em todo o mundo gerando sério problema de saúde pública. Trata-se de um estudo transversal realizado no período de setembro a novembro de 2007. Teve como objetivo identificar a prevalência de fatores de risco para doença cardíaca e analisar associação entre os fatores de risco para doença cardíaca; fizeram parte do estudo 305 empregados da área administrativa da Companhia de Saneamento do Estado de Goiás. Os dados foram coletados por meio da aplicação de formulário e coleta da amostra de sangue. Dados de identificação e os mensuráveis como peso, altura, índice de massa corporal, pressão arterial, obtidos no momento da aplicação do formulário, após o que realizou-se a coleta de sangue para realização da glicemia de jejum e colesterol total…

Advisors/Committee Members: ELINE JONAS, José Rodrigues do Carmo Filho, IRMTRAUT ARACI HOFFMANN PFRIMER, Ana Luiza Lima Sousa.

Subjects/Keywords: high glicemia; Hypertension; Hiperglicemia; CIENCIAS DA SAUDE; Hipercolesterolemia; Obesidade; Hipertensão arterial; SANEAGO; high cholesterol; obesity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Negri, P. W. (2008). PREVALÊNCIA DOS FATORES DE RISCO PARA DOENÇAS CARDIOVASCULARES ENTRE TRABALHADORES ADMINISTRATIVOS DA COMPANHIA DE SANEAMENTO DO ESTADO DE GOIÁS S/A. (Thesis). Universidade Católica de Goiás. Retrieved from http://tede.biblioteca.ucg.br/tde_busca/arquivo.php?codArquivo=531

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Negri, Paulo Wharton. “PREVALÊNCIA DOS FATORES DE RISCO PARA DOENÇAS CARDIOVASCULARES ENTRE TRABALHADORES ADMINISTRATIVOS DA COMPANHIA DE SANEAMENTO DO ESTADO DE GOIÁS S/A.” 2008. Thesis, Universidade Católica de Goiás. Accessed January 24, 2021. http://tede.biblioteca.ucg.br/tde_busca/arquivo.php?codArquivo=531.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Negri, Paulo Wharton. “PREVALÊNCIA DOS FATORES DE RISCO PARA DOENÇAS CARDIOVASCULARES ENTRE TRABALHADORES ADMINISTRATIVOS DA COMPANHIA DE SANEAMENTO DO ESTADO DE GOIÁS S/A.” 2008. Web. 24 Jan 2021.

Vancouver:

Negri PW. PREVALÊNCIA DOS FATORES DE RISCO PARA DOENÇAS CARDIOVASCULARES ENTRE TRABALHADORES ADMINISTRATIVOS DA COMPANHIA DE SANEAMENTO DO ESTADO DE GOIÁS S/A. [Internet] [Thesis]. Universidade Católica de Goiás; 2008. [cited 2021 Jan 24]. Available from: http://tede.biblioteca.ucg.br/tde_busca/arquivo.php?codArquivo=531.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Negri PW. PREVALÊNCIA DOS FATORES DE RISCO PARA DOENÇAS CARDIOVASCULARES ENTRE TRABALHADORES ADMINISTRATIVOS DA COMPANHIA DE SANEAMENTO DO ESTADO DE GOIÁS S/A. [Thesis]. Universidade Católica de Goiás; 2008. Available from: http://tede.biblioteca.ucg.br/tde_busca/arquivo.php?codArquivo=531

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

12. Kopřivová, Hana. Charakterizace katanionických vesikulárních systémů s využitím HRUS: Characterization catanionic vesicular system by HRUS.

Degree: 2020, Brno University of Technology

URL: http://hdl.handle.net/11012/195046

► This bachelor thesis is about catanionic vesicular systems, which could serve as carriers of drugs or genes in the future. These systems are prepared from… (more)

Subjects/Keywords: katanionické vesikulární systémy; ultrazvuková spektroskopie s vysokým rozlišením; densitometrie; cholesterol; catanionic vesicular systems; high resolution ultrasonic spectroscopy; densitometry; cholesterol

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kopřivová, H. (2020). Charakterizace katanionických vesikulárních systémů s využitím HRUS: Characterization catanionic vesicular system by HRUS. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/195046

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kopřivová, Hana. “Charakterizace katanionických vesikulárních systémů s využitím HRUS: Characterization catanionic vesicular system by HRUS.” 2020. Thesis, Brno University of Technology. Accessed January 24, 2021. http://hdl.handle.net/11012/195046.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kopřivová, Hana. “Charakterizace katanionických vesikulárních systémů s využitím HRUS: Characterization catanionic vesicular system by HRUS.” 2020. Web. 24 Jan 2021.

Vancouver:

Kopřivová H. Charakterizace katanionických vesikulárních systémů s využitím HRUS: Characterization catanionic vesicular system by HRUS. [Internet] [Thesis]. Brno University of Technology; 2020. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/11012/195046.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kopřivová H. Charakterizace katanionických vesikulárních systémů s využitím HRUS: Characterization catanionic vesicular system by HRUS. [Thesis]. Brno University of Technology; 2020. Available from: http://hdl.handle.net/11012/195046

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

13. Shang, Xianwen. Associations between dietary consumption and cardiometabolic disorders among community-dwelling Australian adults.

Degree: 2017, University of Melbourne

URL: http://hdl.handle.net/11343/192281

► Background: Cardiometabolic disorders including atherosclerosis, diabetes, and metabolic syndrome (MetS) are major causes of mortality and morbidity. Nutrition is a lifestyle factor that plays an… (more)

▼ Background: Cardiometabolic disorders including atherosclerosis, diabetes, and metabolic syndrome (MetS) are major causes of mortality and morbidity. Nutrition is a lifestyle factor that plays an important role in the development of cardiometabolic disorders. Objective: The research project aimed to examine the association of omega-3 fatty acid intake and dietary quality with abdominal aortic calcification (AAC) among community-dwelling adults from a subset of the Melbourne Collaborative Cohort Study (MCCS) and whether protein intakes from different sources are differently associated with the incident diabetes and MetS in the whole population of the MCCS. Methods: Analyses regarding association of omega-3 fatty acid intakes and dietary quality with AAC were based on a subset (n=312) of the MCCS with diet assessed at baseline (1990-1994) and follow-up (2010-2011) and AAC measured using radiography and dual-energy x-ray absorptiometry (DXA) at follow-up (2010-2011). Analyses regarding protein intakes, diabetes and MetS were conducted using data from the MCCS of 41,514 participants. Dietary intakes, diabetes, and MetS were assessed at both baseline (1990-1994) and follow-up (2003-2007). A meta-analysis of the association between protein intakes and incident diabetes was also conducted. Results: Baseline energy-adjusted alpha linolenic acid (ALA) intake showed inverse associations with AAC severity by both radiography (odds ratio (OR) (95% CI) for tertiles 3 vs 1: 0.49 (0.23, 1.02)) and DXA (0.37 (0.16, 0.83)) in women. Women in the third tertile of total omega-3 fatty acid intake had lower AAC severity by radiography with OR (95% CI) 0.33 (0.16, 0.71) and DXA with OR (95% CI) 0.27 (0.12, 0.62) compared with those in the first tertile. Omega-3 fatty acid intake was not associated with AAC severity in men. Higher baseline dietary quality assessed by Alternate Healthy Eating Index-2010 was associated with lower AAC severity by both radiography (OR (95% CI) for tertiles 3 vs 1: 0.53 (0.29, 0.99)) and DXA (0.38 (0.20, 0.70)). Multivariate-adjusted ORs (95% CIs) of incident MetS for the highest compared with lowest quartile of percentage energy intake from total, animal and plant protein were 1.46 (1.01, 2.10), 1.67 (1.13, 2.48) and 0.60 (0.37, 0.97), respectively. The multivariate-adjusted OR (95% CI) for incident type 2 diabetes in the highest compared with the lowest quintile of animal protein intake as % energy was 1.29 (0.99, 1.67). In the meta-analysis of 11 prospective cohort studies, the pooled relative risks for type 2 diabetes comparing the highest with the lowest category of total, animal, and plant protein intakes were 1.09 (1.06, 1.13), 1.19 (1.11, 1.28), and 0.95 (0.89, 1.02), respectively. Conclusion: Higher intakes of ALA and total omega-3 fatty acids and high quality diets were associated with lower risk of AAC in adults. Higher plant protein and lower animal protein consumption, and substitution of animal protein, were associated with lower incidence of MetS and diabetes. This research…

Subjects/Keywords: abdominal aortic calcification; diabetes; metabolic syndrome; obesity; blood pressure; glucose; cholesterol; high-density lipoprotein cholesterol; low-density lipoprotein cholesterol; dietary protein; dietary quality; omega-3 fatty acid

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shang, X. (2017). Associations between dietary consumption and cardiometabolic disorders among community-dwelling Australian adults. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/192281

Chicago Manual of Style (16^th Edition):

Shang, Xianwen. “Associations between dietary consumption and cardiometabolic disorders among community-dwelling Australian adults.” 2017. Doctoral Dissertation, University of Melbourne. Accessed January 24, 2021. http://hdl.handle.net/11343/192281.

MLA Handbook (7^th Edition):

Shang, Xianwen. “Associations between dietary consumption and cardiometabolic disorders among community-dwelling Australian adults.” 2017. Web. 24 Jan 2021.

Vancouver:

Shang X. Associations between dietary consumption and cardiometabolic disorders among community-dwelling Australian adults. [Internet] [Doctoral dissertation]. University of Melbourne; 2017. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/11343/192281.

Council of Science Editors:

Shang X. Associations between dietary consumption and cardiometabolic disorders among community-dwelling Australian adults. [Doctoral Dissertation]. University of Melbourne; 2017. Available from: http://hdl.handle.net/11343/192281

Edith Cowan University

14. Kanyenda, Limbikani J. Investigating the impact of CD147 and its expression on neurodegenaration and Alzheimer's disease (AD).

Degree: 2012, Edith Cowan University

URL: https://ro.ecu.edu.au/theses/499

► CD147, also known as basigin, extracellular matrix metalloproteinase inducer, neurothelin, tumour cell-derived collagenase stimulatory factor, M6, HT7, OX47 or gp42, is a transmembrane glycoprotein of… (more)

▼ CD147, also known as basigin, extracellular matrix metalloproteinase inducer, neurothelin, tumour cell-derived collagenase stimulatory factor, M6, HT7, OX47 or gp42, is a transmembrane glycoprotein of the immunoglobulin super-family. It is expressed in many neuronal and non-neuronal tissues with high expression in the hippocampus, pre-frontal cortex, thyroid, heart, early erythroid, amygdala and placenta. This protein is involved in various cellular and biological functions such as lymphocyte migration and maturation, tissue repair, cancer progression, T and B lymphocyte activation and induction of extracellular matrix metalloproteinase. The CD147 protein interacts with with cyclophilin A, cyclophilin B, sterol carrier protein, caveolin-1 and integrins, and can influence beta amyloid peptide levels, a protein that is central to Alzheimer’s disease pathology. Mechanisms through which CD147 regulates bata amyloid levels still remain unclear, thus the current study investigated the impact of high cholesterol and beta amyloid 42 loading on CD147 expression in rat primary cortical neuronal cultures. Its expression in human brain tissue from Alzheimer’s disease and non-Alzheimer’s disease dementias and APPswe transgenic mice fed on a high fat/high cholesterol diet were also determined. CD147 over expression experiments in rat primary cortical neuronal and SH-SY5Y cultures using recombinant adenoviruses (AdRSV-CD147 and AdRSV-Empty) in the presence and/or absence of cyclophilin A were employed to determine level of proection against oxidative stress and toxicity. Finally sequencing of the CD147 promoter region (-392 to -242 nucleotides) was perfomed to identify possible single neucrotide polymorphysims that may be linked to Alzheimer’s disease pathology. The in vitro experiments conducted in this study have shown that cholesterol and beta amyloid loading and oxidative stress result in increased CD147 expression in rat primary cortical neuronal cultures and that CD147 protects neuronal cultures from beta amyloid toxicity only in the presence of cylophilin A. However in vivo experiments in animal model have shown that a high fat/high cholesterol diet does not affect brain CD147 levels as evidenced by unchanged expression levels in APPswe mice. Human studies have revealed a correlation between CD147 and γ-secretase complex components (nicastrin and presenilin 1) in the hippocampus. However, there is no difference in CD147 protein expression between hippocampus and frontal cortex from Alzheimer’s disease patients. Sequencing of the CD147 promoter region, where sterol carrier protein binds to initiate CD147 transcription, has identified two novel single neucrotide polymorphysims (-61A>G and 37C>G). However, single neucrotide polymorphysims within this region are not associated with Alzheimer’s disease pathology.

Subjects/Keywords: Alzheimer's Disease; Pathophysiology; Nervous system degeneration; Cholesterol; CD antigens; CD147; Beta Amyloid; High fat /high cholesterol diet; Medical Pathology; Nervous System Diseases; Neurology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kanyenda, L. J. (2012). Investigating the impact of CD147 and its expression on neurodegenaration and Alzheimer's disease (AD). (Thesis). Edith Cowan University. Retrieved from https://ro.ecu.edu.au/theses/499

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kanyenda, Limbikani J. “Investigating the impact of CD147 and its expression on neurodegenaration and Alzheimer's disease (AD).” 2012. Thesis, Edith Cowan University. Accessed January 24, 2021. https://ro.ecu.edu.au/theses/499.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kanyenda, Limbikani J. “Investigating the impact of CD147 and its expression on neurodegenaration and Alzheimer's disease (AD).” 2012. Web. 24 Jan 2021.

Vancouver:

Kanyenda LJ. Investigating the impact of CD147 and its expression on neurodegenaration and Alzheimer's disease (AD). [Internet] [Thesis]. Edith Cowan University; 2012. [cited 2021 Jan 24]. Available from: https://ro.ecu.edu.au/theses/499.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kanyenda LJ. Investigating the impact of CD147 and its expression on neurodegenaration and Alzheimer's disease (AD). [Thesis]. Edith Cowan University; 2012. Available from: https://ro.ecu.edu.au/theses/499

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

RMIT University

15. Li, S. Dietary fat and cholesterol in the pathogenesis of obesity and non-alcoholic fatty liver disease.

Degree: 2016, RMIT University

URL: http://researchbank.rmit.edu.au/view/rmit:161886

► The overall aim of this thesis was to investigate the role of dietary fat and cholesterol in the development of obesity, glucose intolerance and non-alcoholic… (more)

▼ The overall aim of this thesis was to investigate the role of dietary fat and cholesterol in the development of obesity, glucose intolerance and non-alcoholic fatty liver disease (NAFLD) and to investigate possible new mechanisms unravelled from the study. Firstly, this thesis evaluated the metabolic characteristics of mice fed a high-fat (HF) diet and a moderate cholesterol diet (0.2% w/w), alone or in combination, for 17 weeks in light of the gaps of the current knowledge regarding the effect of cholesterol on obesity and related metabolic disorders. The results showed that chronic HF feeding induced obesity, glucose intolerance and simple hepatic steatosis but did not induce signs of non-alcoholic steatohepatitis (NASH). However, mice fed a combination of the HF diet with cholesterol displayed signs of liver injury and hepatic inflammation (indications of NASH) without the exacerbation of obesity and glucose intolerance. Mechanistic investigations suggest that dietary cholesterol may play a critical role in the transition from HF-induced hepatic steatosis towards NASH possibly by activating inflammation reactions within the liver. Furthermore, the study revealed, for the first time, cholesterol blunted mitochondrial function and this phenotype persisted after removing cholesterol from the HF diet. The second part of thesis followed up this new finding of the sustained metabolic phenotype that has a similar feature to the “legacy effect” described in a long-term clinical trial. In this latter study, mice were intermittently fed two episodes of the HF diet with added cholesterol to induce metabolic preconditioning. Intriguingly, the results showed that the preconditioning was protective against obesity and glucose intolerance (but not fatty liver) during subsequent exposure to the same HF diet (with cholesterol) without decreasing calorie intake. Further investigation of the mechanisms underlying the amelioration of obesity showed a transformation of white adipose tissue towards brown adipose tissue (termed “browning”) as indicated by the expression of uncoupling protein 1, a specialised protein to promote energy expenditure as heat. There was an upregulation of some key proteins in the upstream pathway such as SIRT1 in the liver and plasma levels of FGF21 that are known to promote the “browning” of white adipose tissue. These findings suggest that preconditioning with a HF diet with cholesterol may exert “legacy effects” in lessening obesity and glucose intolerance possibly via increasing the capacity of energy expenditure of adipose tissue. In summary, firstly, our studies suggest that cholesterol can precipitate asymptomatic hepatic steatosis towards NASH to worsen the outcome of NAFLD. Secondly, preconditioning may lessen the effects of the HF diet with cholesterol on obesity and glucose intolerance possibly via increasing the capacity of energy expenditure of adipose tissue. These findings provide a scientific rationale for a…

Subjects/Keywords: Fields of Research; Obesity; Non-alcoholic fatty liver disease; Cholesterol; High-fat diet; Legacy effect

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Li, S. (2016). Dietary fat and cholesterol in the pathogenesis of obesity and non-alcoholic fatty liver disease. (Thesis). RMIT University. Retrieved from http://researchbank.rmit.edu.au/view/rmit:161886

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Li, S. “Dietary fat and cholesterol in the pathogenesis of obesity and non-alcoholic fatty liver disease.” 2016. Thesis, RMIT University. Accessed January 24, 2021. http://researchbank.rmit.edu.au/view/rmit:161886.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Li, S. “Dietary fat and cholesterol in the pathogenesis of obesity and non-alcoholic fatty liver disease.” 2016. Web. 24 Jan 2021.

Vancouver:

Li S. Dietary fat and cholesterol in the pathogenesis of obesity and non-alcoholic fatty liver disease. [Internet] [Thesis]. RMIT University; 2016. [cited 2021 Jan 24]. Available from: http://researchbank.rmit.edu.au/view/rmit:161886.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Li S. Dietary fat and cholesterol in the pathogenesis of obesity and non-alcoholic fatty liver disease. [Thesis]. RMIT University; 2016. Available from: http://researchbank.rmit.edu.au/view/rmit:161886

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Technical University of Lisbon

16. Medeiros, Ricardo Miguel Pedroso. Caracterização preliminar dos níveis de colesterol plasmático em canídeos em função do sexo, raça, idade e condição corporal.

Degree: 2011, Technical University of Lisbon

URL: http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/3580

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Dissertação de Mestrado Integrado em Medicina Veterinária

Envolvido em múltiplas funções da homeostasia do corpo, o colesterol, depois de absorvido no lúmen intestinal e processado… (more)

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Dissertação de Mestrado Integrado em Medicina Veterinária

Envolvido em múltiplas funções da homeostasia do corpo, o colesterol, depois de absorvido no lúmen intestinal e processado nos enterócitos, entra na corrente sanguínea onde é transportado sob a forma de lipoproteínas as quais se classificam de acordo com a sua densidade, resultante da quantidade e do tipo de apoproteínas e de colesterol que as constituem, em quilomicras, lipoproteínas de muito baixa densidade (VLDL), lipoproteínas de densidade intermédia (IDL), lipoproteínas de baixa densidade (LDL) e lipoproteínas de alta densidade (HDL), sendo esta última a fracção predominante no cão. É sabido que os valores de colesterol e o perfil das lipoproteínas plasmáticas variam em função de um conjunto de factores intrínsecos e extrínsecos ao indivíduo. O presente estudo utilizou uma amostra de 20 indivíduos (n=20) da espécie Canis lupus familiaris, e teve por objectivos: 1) Caracterizar os indivíduos incluídos no estudo quanto ao sexo, raça, idade e condição corporal; 2) Determinar a relação entre os valores plasmáticos de COL e as variáveis consideradas em 1); 3) Determinar a relação entre os valores plasmáticos de HDL-C e as variáveis consideradas em 1); 4) Determinar a relação entre os valores plasmáticos de COL e HDL-C. Os resultados obtidos permitiram concluir que na amostra a média dos valores de COL foi de 223,20±85,54mg/dL, encontrando-se a maioria dos indivíduos (95%) numa situação de normocolesterolémia. Os indivíduos mais velhos, os mais obesos e as fêmeas inteiras, foram os que apresentaram os valores de COL mais elevados. Para o HDL-C, a média foi de 86,02±10,37mg/dL, tendo sido os valores mais elevados registados em fêmeas inteiras, e os mais baixos nos indivíduos obesos. Os testes estatísticos realizados não permitiram contudo excluir a hipótese nula da ausência de diferenças nos valores de COL e de HDL-C, considerando os parâmetros sexo, raça e condição corporal para ambos e ainda, para o HDL-C, o factor idade.

ABSTRACT - Preliminary characterization of plasmatic cholesterol values in dogs based on gender, age, breed and body condition - Playing a role in multiple functions of the body homeostasis, the cholesterol, after being absorbed at intestinal lumen and processed by the enterocyte, reaches bloodstream, where its transport is performed by lipoproteins, classified by their density, which result from its constitution in apoproteins and cholesterol, in chylomicrons, very-low density lipoproteins (VLDL), intermediate density lipoproteins (IDL), low-density lipoproteins (LDL) and high-density lipoproteins (HDL), being this last one the predominant fraction in the dog. It is well known that total cholesterol and the profile of plasmatic lipoproteins vary in function of a set of factors, intrinsic and extrinsic to the individuals. The present study used a sample of 20 individuals of Canis lupus familiaris specie, to achieve the following objectives: 1) characterize the individuals included according to their gender, breed, age and body…

Advisors/Committee Members: Vicente, Gonçalo Eduardo Vítor, Carreira, Luís Miguel Alves.

Subjects/Keywords: Canídeo; Lipoproteínas plasmáticas; Colesterol; Lipoproteínas de alta densidade; Dog; Plasmatic Lipoproteins; Cholesterol; High-density lipoproteins

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Medeiros, R. M. P. (2011). Caracterização preliminar dos níveis de colesterol plasmático em canídeos em função do sexo, raça, idade e condição corporal. (Thesis). Technical University of Lisbon. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/3580

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Medeiros, Ricardo Miguel Pedroso. “Caracterização preliminar dos níveis de colesterol plasmático em canídeos em função do sexo, raça, idade e condição corporal.” 2011. Thesis, Technical University of Lisbon. Accessed January 24, 2021. http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/3580.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Medeiros, Ricardo Miguel Pedroso. “Caracterização preliminar dos níveis de colesterol plasmático em canídeos em função do sexo, raça, idade e condição corporal.” 2011. Web. 24 Jan 2021.

Vancouver:

Medeiros RMP. Caracterização preliminar dos níveis de colesterol plasmático em canídeos em função do sexo, raça, idade e condição corporal. [Internet] [Thesis]. Technical University of Lisbon; 2011. [cited 2021 Jan 24]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/3580.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Medeiros RMP. Caracterização preliminar dos níveis de colesterol plasmático em canídeos em função do sexo, raça, idade e condição corporal. [Thesis]. Technical University of Lisbon; 2011. Available from: http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/3580

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Minnesota

17. Ford, Kristen A. Molecular mechanism of the anti-inflammatory effect of fenofibrate.

Degree: MS, Clinical Laboratory Science, 2010, University of Minnesota

URL: http://purl.umn.edu/90887

University of Minnesota M.S. thesis. April 2010. Major: Clinical Laboratory Science. Advisor: Michael Y. Tsai. 1 computer file (PDF); vii, 62 pages. Ill. (some col.)

Summary abstract not available.

Advisors/Committee Members: Michael Y. Tsai.

Subjects/Keywords: Cardiovascular disease; LpPLA2; Reverse Cholesterol transport; High density lipoprotein; Clinical Laboratory Science

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APA (6^th Edition):

Ford, K. A. (2010). Molecular mechanism of the anti-inflammatory effect of fenofibrate. (Masters Thesis). University of Minnesota. Retrieved from http://purl.umn.edu/90887

Chicago Manual of Style (16^th Edition):

Ford, Kristen A. “Molecular mechanism of the anti-inflammatory effect of fenofibrate.” 2010. Masters Thesis, University of Minnesota. Accessed January 24, 2021. http://purl.umn.edu/90887.

MLA Handbook (7^th Edition):

Ford, Kristen A. “Molecular mechanism of the anti-inflammatory effect of fenofibrate.” 2010. Web. 24 Jan 2021.

Vancouver:

Ford KA. Molecular mechanism of the anti-inflammatory effect of fenofibrate. [Internet] [Masters thesis]. University of Minnesota; 2010. [cited 2021 Jan 24]. Available from: http://purl.umn.edu/90887.

Council of Science Editors:

Ford KA. Molecular mechanism of the anti-inflammatory effect of fenofibrate. [Masters Thesis]. University of Minnesota; 2010. Available from: http://purl.umn.edu/90887

University of Michigan

18. Fawaz, Maria. Apolipoprotein A-I Mimetics for the Treatment of Niemann-Pick Disease.

Degree: PhD, Medicinal Chemistry, 2020, University of Michigan

URL: http://hdl.handle.net/2027.42/155067

► Niemann-Pick disease (NPD) is a fatal lipid storage disorder that results in an accumulation of unesterified cholesterol (type C) or sphingomyelin (types A and B)… (more)

▼ Niemann-Pick disease (NPD) is a fatal lipid storage disorder that results in an accumulation of unesterified cholesterol (type C) or sphingomyelin (types A and B) in late endosomes and lysosomes. Inherited defects in NPC1 or NPC2 genes are responsible for NPD type C (NPC) while mutations in SMPD1 gene cause NPD types A (NPA) and B (NPB). To date, NPD management is largely symptomatic with only few therapies in clinical trials. Therefore, the main objective of this dissertation was to develop safe and effective therapeutics for the treatment of NPA/B and NPC. In NPD, the defects in cholesterol and sphingomyelin metabolism cause a panel of cellular problems including markedly decreased levels of high-density lipoproteins (HDL) responsible for the extracellular lipid transport. The body produces HDL as an 8-12 nm nanoparticle composed of a lipid membrane wrapped around by a belt of Apolipoprotein A-I (ApoA-I). Several synthetic HDL (sHDL) particles made of ApoA-I or ApoA-I mimetic peptides complexed with various phospholipids have been previously tested in patients for the treatment of atherosclerosis, where sHDL has been found safe at doses up to 100 mg/kg following intravenous administration. Applying the same strategy to NPD, we proposed that ApoA-I mimetics (peptide or sHDL) could be effective and rapidly translatable therapeutic approaches for the treatment of NPD. In the second chapter, we investigated the therapeutic potential of ApoA-I mimetic peptides and sHDL in NPC. Nanoparticles, particularly 5A-SM sHDL, were effective at reducing cholesterol accumulations in human NPC cells and resulted in the rescue of peripheral disease with intraperitoneal route in NPC1 mice. However, the correction of motor function was not detected. A direct brain administration of sHDL reduced cholesterol storage in neurons of NPC1 mice suggesting that the alternative delivery routes, treatment durations, or sHDL composition were still needed to be investigated. In the third chapter, we used a similar strategy to NPC. We identified a peptide, 22A, and sHDL capable of reducing sphingomyelin levels in human NPA cells. Moreover, the ATP-binding cassette A1 transporter was found to be involved in sphingomyelin efflux from cells. Intravenous administration of 22A to wild type mice rapidly mobilized sphingomyelin from tissues into circulation. In addition to sphingomyelin, peptide and sHDL could both mobilize cholesterol, which was found to be elevated in NPA disease. Together, our data showed that ApoA-I mimetics might represent a novel therapeutic approach for NPA disease. In the fourth chapter, we systematically evaluated the effect of both peptide sequence and phospholipid composition of sHDL on nanoparticle’s ability to mobilize and esterify cholesterol in vitro and in vivo. Historically, sHDL drug discovery efforts were mainly focused on optimizing peptide sequences rather than understanding how both, peptide and lipid, influence sHDL pharmacokinetic and pharmacodynamic profiles. Two sets of sHDL were designed having either… Advisors/Committee Members: Schwendeman, Anna A S (committee member), Carlson, Heather A (committee member), Lieberman, Andrew P (committee member), Neamati, Nouri (committee member).

Subjects/Keywords: Apolipoprotein A-I mimetics; Niemann-Pick disease; High-density lipoprotein; Cholesterol trafficking; Sphingomyelin; Chemistry; Science

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APA (6^th Edition):

Fawaz, M. (2020). Apolipoprotein A-I Mimetics for the Treatment of Niemann-Pick Disease. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/155067

Chicago Manual of Style (16^th Edition):

Fawaz, Maria. “Apolipoprotein A-I Mimetics for the Treatment of Niemann-Pick Disease.” 2020. Doctoral Dissertation, University of Michigan. Accessed January 24, 2021. http://hdl.handle.net/2027.42/155067.

MLA Handbook (7^th Edition):

Fawaz, Maria. “Apolipoprotein A-I Mimetics for the Treatment of Niemann-Pick Disease.” 2020. Web. 24 Jan 2021.

Vancouver:

Fawaz M. Apolipoprotein A-I Mimetics for the Treatment of Niemann-Pick Disease. [Internet] [Doctoral dissertation]. University of Michigan; 2020. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/2027.42/155067.

Council of Science Editors:

Fawaz M. Apolipoprotein A-I Mimetics for the Treatment of Niemann-Pick Disease. [Doctoral Dissertation]. University of Michigan; 2020. Available from: http://hdl.handle.net/2027.42/155067

University of South Carolina

19. Ruiz-Ramie, Jonathan Joseph Pulama Kupaianaha. Lipoprotein Discordance: Associations With Diabetes, Metabolic Syndrome, and Response to Exercise.

Degree: PhD, Exercise Science, 2020, University of South Carolina

URL: https://scholarcommons.sc.edu/etd/5677

► Purpose: To compare baseline CVD risk factor profiles among groups of individuals with discordant levels of high- and low-density lipoprotein cholesterol (HDL-C and LDL-C… (more)

▼ Purpose: To compare baseline CVD risk factor profiles among groups of individuals with discordant levels of high- and low-density lipoprotein cholesterol (HDL-C and LDL-C respectively) compared to lipoprotein particle concentration (HDL-P and LDL-P respectively) and examine the associations between lipoprotein discordance and incident type 2 diabetes mellitus (T2D) and metabolic syndrome (MetS). Furthermore, to examine the association between lipoprotein discordance and exercise induced changes in CVD risk factors. Methods: Standard lipid panels as well as lipoprotein subclass profiles via nuclear magnetic resonance spectroscopy were measured among three previously completed studies (CARDIA cohort, HERITAGE Family Study, and HART-D study) spanning over 4,000 male and female participants. 1) Aerobic training only (AT), 2) Resistance training only (RT), 3) Combined AT/RT. Four exclusive HDL and LDL discordance groups were created based on baseline median lipoprotein cholesterol/particle concentrations as follows: 1) low/low (< median for both cholesterol and particle), 2) low/high (< median cholesterol, ≥ median particle), 3) high/low, and 4) high/high. Cross-sectional associations between baseline discordance group and CVD risk factors were assessed via multivariable linear regression. Continuous discordance levels were created by subtracting individual particle percentile ranking from cholesterol percentile ranking (e.g. HDL-C – HDL-P). The association between continuous lipoprotein discordance and cross-sectional CVD risk factors was assessed correlational analysis, while the association of incident T2D or MetS with lipoprotein discordance was assessed via multivariable proportional hazards regression. The relationship between lipoprotein discordance and exercise induced changes in CVD risk factors was assessed via multivariable linear regression. Results: Cross sectional analyses revealed that for HDL discordance, more favorable risk profiles (e.g. lower BMI, larger mean HDL-P and LDL-P size) were associated with higher HDL-C, while in LDL discordance groups more favorable risk factors were associated with lower LDL-P. In women only, both HDL and LDL discordance were associated with T2D and MetS risk with higher risk being associated with lower HDL-C and higher LDL-P. Associations of lipoprotein discordance with exercise induced changes in CVD risk factors were primarily limited to lipoprotein specific variables (e.g. HDL discordance significantly associated with changes in mean HDL-P size). Conclusions: Lipoprotein discordance is associated with cross-sectional differences in CVD risk factors with more favorable risk factor profiles being found in those with high HDL-C and low LDL-P regardless of discordance status. Lipoprotein concordant/discordant status is also a significant risk factor for both T2D and MetS in women only, although racial disparities may be present. Furthermore, lipoprotein discordance status is… Advisors/Committee Members: Mark A. Sarzynski.

Subjects/Keywords: Exercise Science; cholesterol; discordance; high density lipoprotein; lipoprotein; low density lipoprotein; NMR

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APA (6^th Edition):

Ruiz-Ramie, J. J. P. K. (2020). Lipoprotein Discordance: Associations With Diabetes, Metabolic Syndrome, and Response to Exercise. (Doctoral Dissertation). University of South Carolina. Retrieved from https://scholarcommons.sc.edu/etd/5677

Chicago Manual of Style (16^th Edition):

Ruiz-Ramie, Jonathan Joseph Pulama Kupaianaha. “Lipoprotein Discordance: Associations With Diabetes, Metabolic Syndrome, and Response to Exercise.” 2020. Doctoral Dissertation, University of South Carolina. Accessed January 24, 2021. https://scholarcommons.sc.edu/etd/5677.

MLA Handbook (7^th Edition):

Ruiz-Ramie, Jonathan Joseph Pulama Kupaianaha. “Lipoprotein Discordance: Associations With Diabetes, Metabolic Syndrome, and Response to Exercise.” 2020. Web. 24 Jan 2021.

Vancouver:

Ruiz-Ramie JJPK. Lipoprotein Discordance: Associations With Diabetes, Metabolic Syndrome, and Response to Exercise. [Internet] [Doctoral dissertation]. University of South Carolina; 2020. [cited 2021 Jan 24]. Available from: https://scholarcommons.sc.edu/etd/5677.

Council of Science Editors:

Ruiz-Ramie JJPK. Lipoprotein Discordance: Associations With Diabetes, Metabolic Syndrome, and Response to Exercise. [Doctoral Dissertation]. University of South Carolina; 2020. Available from: https://scholarcommons.sc.edu/etd/5677

University of Technology, Sydney

20. Kasz, Robert. Investigating DHCR24 as a protector against cellular stress : more than just a cholesterol-synthesising enzyme.

Degree: 2017, University of Technology, Sydney

URL: http://hdl.handle.net/10453/90267

► Atherosclerosis and insulin resistance are globally prevalent metabolic diseases, primarily driven by endothelial and hepatic inflammation, respectively. High density lipoprotein (HDL) reduces the inflammation in… (more)

▼ Atherosclerosis and insulin resistance are globally prevalent metabolic diseases, primarily driven by endothelial and hepatic inflammation, respectively. High density lipoprotein (HDL) reduces the inflammation in models of atherosclerosis and insulin sensitivity, and in doing so, improves these conditions. Our laboratory has demonstrated that in human coronary artery endothelial cells (HCAECs), HDL’s suppression of the inflammatory response is a gene-regulated process and that 3β-hydroxysteroid-Δ24 reductase (DHCR24) is one of the most upregulated genes by HDL. DHCR24 is a cholesterol biosynthesis enzyme however, recent work in various cell types shows DHCR24 emerging as a potent multifaceted protein protecting against cellular stress. This study commenced with confirming apolipoprotein I (apoA-I) rHDL increases DHCR24 expression in HCAECs, while revealing for the first time that HDL also increases DHCR24 expression in human hepatoma 7 (HuH7) cells. This study next questioned whether DHCR24 mimics apoA-I rHDL’s suppression of the inflammatory response in these cell types. The data presented provides proof-of-principle that DHCR24 replicates HDL’s suppression of tumour necrosis factor-alpha (TNF-α)-induced intracellular cell adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) levels in HCAECs, and interleukin 8 (IL-8) levels in HuH7 cells. Characterising DHCR24’s role was explored to learn more about how DHCR24 suppresses a TNF-α-induced inflammatory response in HCAECs and HuH7 cells. This study showed that DHCR24’s oxidoreductase region mediates DHCR24’s suppression of a TNF-α-induced inflammatory response in these cell types. This effect occurred without DHCR24 increasing cholesterol levels, despite the oxidoreductase site’s integral role in cholesterol biosynthesis. These are exciting results as they indicate that DHCR24 is more than just a cholesterol biosynthesis enzyme in HCAECs and HuH7 cells. Elucidating the mechanisms by which DHCR24 suppresses a TNF-α-induced inflammatory response in HCAECs and HuH7 cells highlighted a cell type-specific nature of DHCR24’s activity, which is in keeping with reports in the literature. In keeping with this cell type-specificity, a TNF-α-induced inflammatory response was suppressed, in part, by a decreased endoplasmic reticulum (ER) stress response in HCAECs. Interestingly, this did not occur in HuH7 cells. The work here suggests that this is attributed to the increased cholesterol content in HuH7 cells compared to HCAECs. DHCR24’s cell type-specific effects are reinforced by the cellular response of DHCR24 levels to TNF-α-activation – in HCAECs, DHCR24 levels were modestly increased; conversely in HuH7 cells, TNF-α-activation markedly decreased DHCR24 levels. Moreover, TNF-α-activation caused DHCR24’s translocation from its ER-localisation to the cytoplasm and nucleus, while in HuH7 cells, DHCR24 remained localised peri-nuclearly. This data provides novel mechanistic insight into DHCR24’s multifunctional role in two different cell types, laying the…

Subjects/Keywords: Atherosclerosis.; Insulin resistance.; Cholesterol biosynthesis enzyme DHCR24; High density lipoprotein (HDL); HCAECs and HuH7 cells.

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APA (6^th Edition):

Kasz, R. (2017). Investigating DHCR24 as a protector against cellular stress : more than just a cholesterol-synthesising enzyme. (Thesis). University of Technology, Sydney. Retrieved from http://hdl.handle.net/10453/90267

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kasz, Robert. “Investigating DHCR24 as a protector against cellular stress : more than just a cholesterol-synthesising enzyme.” 2017. Thesis, University of Technology, Sydney. Accessed January 24, 2021. http://hdl.handle.net/10453/90267.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kasz, Robert. “Investigating DHCR24 as a protector against cellular stress : more than just a cholesterol-synthesising enzyme.” 2017. Web. 24 Jan 2021.

Vancouver:

Kasz R. Investigating DHCR24 as a protector against cellular stress : more than just a cholesterol-synthesising enzyme. [Internet] [Thesis]. University of Technology, Sydney; 2017. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/10453/90267.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kasz R. Investigating DHCR24 as a protector against cellular stress : more than just a cholesterol-synthesising enzyme. [Thesis]. University of Technology, Sydney; 2017. Available from: http://hdl.handle.net/10453/90267

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Arizona

21. Hassel, Craig Alan. LIPOPROTEIN RECEPTORS IN COPPER-DEFICIENT RATS: IN VITRO BINDING OF HIGH DENSITY LIPOPROTEIN SUBFRACTIONS TO LIVER MEMBRANES.

Degree: 1986, University of Arizona

URL: http://hdl.handle.net/10150/183955

► Three studies were conducted to determine whether the elevated plasma and HDL cholesterol levels observed in copper-deficient rats could be explained by the interaction of… (more)

Subjects/Keywords: Copper – Nutrition.; Cholesterol.; High density lipoproteins.

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APA (6^th Edition):

Hassel, C. A. (1986). LIPOPROTEIN RECEPTORS IN COPPER-DEFICIENT RATS: IN VITRO BINDING OF HIGH DENSITY LIPOPROTEIN SUBFRACTIONS TO LIVER MEMBRANES. (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/183955

Chicago Manual of Style (16^th Edition):

Hassel, Craig Alan. “LIPOPROTEIN RECEPTORS IN COPPER-DEFICIENT RATS: IN VITRO BINDING OF HIGH DENSITY LIPOPROTEIN SUBFRACTIONS TO LIVER MEMBRANES. ” 1986. Doctoral Dissertation, University of Arizona. Accessed January 24, 2021. http://hdl.handle.net/10150/183955.

MLA Handbook (7^th Edition):

Hassel, Craig Alan. “LIPOPROTEIN RECEPTORS IN COPPER-DEFICIENT RATS: IN VITRO BINDING OF HIGH DENSITY LIPOPROTEIN SUBFRACTIONS TO LIVER MEMBRANES. ” 1986. Web. 24 Jan 2021.

Vancouver:

Hassel CA. LIPOPROTEIN RECEPTORS IN COPPER-DEFICIENT RATS: IN VITRO BINDING OF HIGH DENSITY LIPOPROTEIN SUBFRACTIONS TO LIVER MEMBRANES. [Internet] [Doctoral dissertation]. University of Arizona; 1986. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/10150/183955.

Council of Science Editors:

Hassel CA. LIPOPROTEIN RECEPTORS IN COPPER-DEFICIENT RATS: IN VITRO BINDING OF HIGH DENSITY LIPOPROTEIN SUBFRACTIONS TO LIVER MEMBRANES. [Doctoral Dissertation]. University of Arizona; 1986. Available from: http://hdl.handle.net/10150/183955

22. Jahani, Mehrnoosh. Studies on Lipoprotein Specificity of Human Plasma Lecithin Cholesterol Acyltransferase.

Degree: 1981, North Texas State University

URL: https://digital.library.unt.edu/ark:/67531/metadc504553/

► Huian plasma high-density lipoprotein (HDL) were isolated by a procedure employing polyanion precipitation and column chromatography. Lipid and protein composition of the HDL isolated by… (more)

Subjects/Keywords: high-density lipoprotein; human plasma; HDL; LCAT; lecithin cholesterol acyltransferase; Blood lipoproteins.; Cholesterol – Metabolism.; Lecithin cholesterol acyltransferase.

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APA (6^th Edition):

Jahani, M. (1981). Studies on Lipoprotein Specificity of Human Plasma Lecithin Cholesterol Acyltransferase. (Thesis). North Texas State University. Retrieved from https://digital.library.unt.edu/ark:/67531/metadc504553/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jahani, Mehrnoosh. “Studies on Lipoprotein Specificity of Human Plasma Lecithin Cholesterol Acyltransferase.” 1981. Thesis, North Texas State University. Accessed January 24, 2021. https://digital.library.unt.edu/ark:/67531/metadc504553/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jahani, Mehrnoosh. “Studies on Lipoprotein Specificity of Human Plasma Lecithin Cholesterol Acyltransferase.” 1981. Web. 24 Jan 2021.

Vancouver:

Jahani M. Studies on Lipoprotein Specificity of Human Plasma Lecithin Cholesterol Acyltransferase. [Internet] [Thesis]. North Texas State University; 1981. [cited 2021 Jan 24]. Available from: https://digital.library.unt.edu/ark:/67531/metadc504553/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jahani M. Studies on Lipoprotein Specificity of Human Plasma Lecithin Cholesterol Acyltransferase. [Thesis]. North Texas State University; 1981. Available from: https://digital.library.unt.edu/ark:/67531/metadc504553/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

23. Kamlesh Kumar. To evaluate the changes in lipid lipoprotein prfile induced after ingestion of high cholesterol and fat diaet in healthy females; -.

Degree: Medicine, 1988, Bundelkhand University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/15320

None

Bibliography p.76-89

Advisors/Committee Members: Arora, R C.

Subjects/Keywords: Medicine; fat diaet; high cholesterol; healthy females

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APA (6^th Edition):

Kumar, K. (1988). To evaluate the changes in lipid lipoprotein prfile induced after ingestion of high cholesterol and fat diaet in healthy females; -. (Thesis). Bundelkhand University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/15320

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kumar, Kamlesh. “To evaluate the changes in lipid lipoprotein prfile induced after ingestion of high cholesterol and fat diaet in healthy females; -.” 1988. Thesis, Bundelkhand University. Accessed January 24, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/15320.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kumar, Kamlesh. “To evaluate the changes in lipid lipoprotein prfile induced after ingestion of high cholesterol and fat diaet in healthy females; -.” 1988. Web. 24 Jan 2021.

Vancouver:

Kumar K. To evaluate the changes in lipid lipoprotein prfile induced after ingestion of high cholesterol and fat diaet in healthy females; -. [Internet] [Thesis]. Bundelkhand University; 1988. [cited 2021 Jan 24]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15320.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kumar K. To evaluate the changes in lipid lipoprotein prfile induced after ingestion of high cholesterol and fat diaet in healthy females; -. [Thesis]. Bundelkhand University; 1988. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15320

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

24. Prasanthi, P. Hypolipidemic effect of high fiber and omega 3 rich foods; -.

Degree: Nutrition, 2014, Avinashilingam Deemed University For Women

URL: http://shodhganga.inflibnet.ac.in/handle/10603/27454

►

Proper nutrition and exercise are widely known to prevent and reverse the ubiquitous national degenerative disease In the present context hyperlipidemia one of the major… (more)

▼

Proper nutrition and exercise are widely known to prevent and reverse the ubiquitous national degenerative disease In the present context hyperlipidemia one of the major underlying causes for several chronic diseases including coronary artery disease and thus leading to cardiovascular diseases newlineis an elevation in atherogenic lipoprotein particles including cholesterol cholesterol esters and triglycerides and low HDLcholesterol level The present study was carried with an objective to reduce newlinethe lipid parameter levels with food based approach The study was conducted at Care Hospitals Hyderabad and 1000 subjects of both sexes were selected in the age group of 35 to 75 years and had a cholesterol level of greater than 200 mg dl Data was collected on demographic profile dietary pattern lifestyle pattern anthropometric and biochemical parameters using well structured questionnaire and interview method Omega 3 and high fibre rich foods like nuts almonds walnuts and flaxseeds were used for the newlineintervention Among 441 male and 559 female hyperlipidemics most of them had education upto professional degree holding higher positions doing business and some retired personnel They were involved in sedentary activity belongs to nuclear family system with high income level Most of them newlineare nonvegetarians and used sunflower oil for cooking Alcohol consumption and smoking pattern was observed only among male hyperlipidemics Majority of the hyperlipidemics were involved in mild newlineexercise and had personal history of the disorder for 5 to 10 years along with family history and were taking allopathy as mode of treatment Body mass index showed that majority of them are under overweight newlinecategory and found to be obese Lipid parameters were high in both the sexes For the intervention study 150 hyperlipidemics in the age of 40 to 60 years were selected whose total cholesterol level was greatet than 240mg dl of which four are experimental and one control group

-

Advisors/Committee Members: Amirthaveni, M.

Subjects/Keywords: Hyperlipidemia; CVD; cholesterol; nuts; omega 3 fatty acids and high fiber foods; Food Science and Nutrition

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APA (6^th Edition):

Prasanthi, P. (2014). Hypolipidemic effect of high fiber and omega 3 rich foods; -. (Thesis). Avinashilingam Deemed University For Women. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/27454

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Prasanthi, P. “Hypolipidemic effect of high fiber and omega 3 rich foods; -.” 2014. Thesis, Avinashilingam Deemed University For Women. Accessed January 24, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/27454.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Prasanthi, P. “Hypolipidemic effect of high fiber and omega 3 rich foods; -.” 2014. Web. 24 Jan 2021.

Vancouver:

Prasanthi P. Hypolipidemic effect of high fiber and omega 3 rich foods; -. [Internet] [Thesis]. Avinashilingam Deemed University For Women; 2014. [cited 2021 Jan 24]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/27454.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Prasanthi P. Hypolipidemic effect of high fiber and omega 3 rich foods; -. [Thesis]. Avinashilingam Deemed University For Women; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/27454

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

25. C. Sensi. LCAT MOLECULAR MODELING:APPLICATIONS TO STRUCTURE-FUNCTION RELATIONSHIPS AND TO INHIBITOR DISCOVERY.

Degree: 2013, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/216122

► A series of large population studies have revealed the existence of a strong inverse correlation between plasma levels of high-density lipoprotein cholesterol (HDL-C) and cardiovascular… (more)

▼ A series of large population studies have revealed the existence of a strong inverse correlation between plasma levels of high-density lipoprotein cholesterol (HDL-C) and cardiovascular risk. Accordingly, HDL has become a major target for the development of novel therapies for the treatment of atherosclerotic cardiovascular disease. LCAT catalyzes cholesteryl ester synthesis and plays a central role in HDL structure and metabolism. Also, LCAT promotes the reverse cholesterol transport, and mediates its atheroprotective effects. Recent studies demonstrated that decreasing LCAT activity possibly has positive effects on HDL structure/function, and may represent a novel therapeutic strategy to reduce cardiovascular risk. To exploit LCAT therapeutic prospects, the availability of new potent and selective LCAT modulators is mandatory. With the present work, we identified molecules able to inhibit LCAT enzymatic activity implementing an in silico strategy. The computational approach can be deployed in two different ways: i) the availability of large chemical databases, and the computational power of the new computers allow a very efficient in silico high-throughput screening starting from the target structure and independently of any pharmacophoric hypothesis; ii) the knowledge of the active site and of the catalytic mechanism of a target can be exploited for ab initio computer-aided drug design. We have designed, through a de novo approach, an irreversible inhibitor, which is the first specific LCAT inhibitor known, and can be considered as a lead compound for the identification of new active molecules belonging to the same chemical family. In parallel, the high-throughput screening carried out on LCAT identified some very potent reversible inhibitors, which can be of interest in further drug development steps. Globally, this project produced innovative pharmacological entities to be further developed for a completely new therapeutic approach to the treatment of atherosclerotic cardiovascular diseases. Advisors/Committee Members: tutor: E. Gianazza, I. Eberini, A. Ferraretto, coordinatore: A. Pagani, GIANAZZA, ELISABETTA, PAGANI, MARIA AMBROGINA.

Subjects/Keywords: cholesterol; cardiovascular disease; atherosclerosis; HDL; LCAT; molecular modeling; high-throughput screening; computer-aided molecular design; Settore BIO/10 - Biochimica

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APA (6^th Edition):

Sensi, C. (2013). LCAT MOLECULAR MODELING:APPLICATIONS TO STRUCTURE-FUNCTION RELATIONSHIPS AND TO INHIBITOR DISCOVERY. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/216122

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sensi, C.. “LCAT MOLECULAR MODELING:APPLICATIONS TO STRUCTURE-FUNCTION RELATIONSHIPS AND TO INHIBITOR DISCOVERY.” 2013. Thesis, Università degli Studi di Milano. Accessed January 24, 2021. http://hdl.handle.net/2434/216122.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sensi, C.. “LCAT MOLECULAR MODELING:APPLICATIONS TO STRUCTURE-FUNCTION RELATIONSHIPS AND TO INHIBITOR DISCOVERY.” 2013. Web. 24 Jan 2021.

Vancouver:

Sensi C. LCAT MOLECULAR MODELING:APPLICATIONS TO STRUCTURE-FUNCTION RELATIONSHIPS AND TO INHIBITOR DISCOVERY. [Internet] [Thesis]. Università degli Studi di Milano; 2013. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/2434/216122.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sensi C. LCAT MOLECULAR MODELING:APPLICATIONS TO STRUCTURE-FUNCTION RELATIONSHIPS AND TO INHIBITOR DISCOVERY. [Thesis]. Università degli Studi di Milano; 2013. Available from: http://hdl.handle.net/2434/216122

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manitoba

26. Wu, Nan. Regulation of hepatic inflammatory response and lipid metabolism in metabolic disease.

Degree: Physiology, 2009, University of Manitoba

URL: http://hdl.handle.net/1993/23352

► Hyperhomocysteinemia, an elevation of blood homocysteine levels, is a metabolic disorder associated with dysfunction of multiple organs. Previous studies have shown that hyperhomocysteinemia is related… (more)

▼ Hyperhomocysteinemia, an elevation of blood homocysteine levels, is a metabolic disorder associated with dysfunction of multiple organs. Previous studies have shown that hyperhomocysteinemia is related to fatty liver. However, the underlying mechanism remains speculative. The objective of the present study is to investigate the regulatory mechanism of hepatic inflammatory response and cholesterol metabolism during metabolic disorders. In the present study, hyperhomocysteinemia was induced in Sprague-Dawley rats by feeding a high-methionine diet. The mRNA and protein expression of cyclooxygenase-2 (COX-2), a pro-inflammatory factor, were significantly elevated in the liver of hyperhomocysteinemic rats. An activation of NF-B and a stimulation of oxidative stress were observed in the same liver tissue in which COX-2 was induced. Inhibition of NF-B or oxidative stress effectively abolished hepatic COX-2 expression, inhibited the formation of inflammatory foci, and improved liver function. Activity of HMG-CoA reductase, the rate-limiting enzyme of cholesterol biosynthesis, was markedly elevated in the liver of hyperhomocysteinemic rats, which may contribute to the hepatic lipid accumulation induced by hyperhomocysteinemia. Administration of Berberine (5mg/ kg body weight/ day for 5 days) inhibited HMG-CoA reductase activity via upregulating AMP-activated protein kinase (AMPK)-mediated phosphorylation of HMG-CoA reductase. Berberine treatment reduced hepatic cholesterol content and ameliorated liver function. In addition, the regulatory mechanism of HMG-CoA reductase activation was investigated in C57BL/6 mice fed a high-fat diet. There was a significant increase in hepatic HMG-CoA reductase mRNA and protein expression as well as enzyme activity. The DNA binding activity of sterol regulatory element binding protein (SREBP)-2 (a transcription factor of HMG-CoA reductase) and Sp1 (a transcription factor of SREBP-2) were both increased in the liver of mice fed a high-fat diet. The in vitro study in palmitic acid-treated HepG2 cells further confirmed that inhibition of Sp1 by siRNA transfection abolished palmitic acid-induced SREBP-2 and HMG-CoA reductase mRNA expression. In conclusion, the present study have demonstrated that (1) Hepatic COX-2 expression is induced via oxidative stress mediated NF-B activation during hyperhomocysteinemia; (2) Dietary berberine reduces cholesterol biosynthesis by elevating AMPK-mediated HMG-CoA reductase phosphorylation; (3) HMG-CoA reductase is upregulated by Sp1-mediated SREBP-2 activation in the liver during high-fat diet feeding. Advisors/Committee Members: O, Karmin (Physiology) (supervisor), Hatch, Grant (Biochem & Med Genetics) Pierce, Grant (Physiology) Shiu, Robert (Physiology) Man, Ricky Y.K. (University of Hong Kong) (examiningcommittee).

Subjects/Keywords: Liver; inflammatory response; cholesterol biosynthesis; hyperhomocysteinemia; high fat diet

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wu, N. (2009). Regulation of hepatic inflammatory response and lipid metabolism in metabolic disease. (Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/23352

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wu, Nan. “Regulation of hepatic inflammatory response and lipid metabolism in metabolic disease.” 2009. Thesis, University of Manitoba. Accessed January 24, 2021. http://hdl.handle.net/1993/23352.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wu, Nan. “Regulation of hepatic inflammatory response and lipid metabolism in metabolic disease.” 2009. Web. 24 Jan 2021.

Vancouver:

Wu N. Regulation of hepatic inflammatory response and lipid metabolism in metabolic disease. [Internet] [Thesis]. University of Manitoba; 2009. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/1993/23352.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wu N. Regulation of hepatic inflammatory response and lipid metabolism in metabolic disease. [Thesis]. University of Manitoba; 2009. Available from: http://hdl.handle.net/1993/23352

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Boston University

27. Lai, Lana Yin Hui. Association of Apolipoprotein E (Apo E) polymorphism with the prevalence of metabolic syndrome (MetS): the National Heart, Lung and Blood Institute Family Heart Study.

Degree: MA, Clinical Investigation, 2013, Boston University

URL: http://hdl.handle.net/2144/17153

► BACKGROUND & AIMS - Metabolic syndrome (MetS), characterized by abdominal obesity, atherogenic dyslipidemia, elevated blood pressure, and insulin resistance is a major public health concern… (more)

Subjects/Keywords: Apolipoprotein E (Apo E) polymorphism; Metabolic syndrome; Blood pressure; Glucose; Waist circumference; Triglycerides; High-density lipoprotein cholesterol

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lai, L. Y. H. (2013). Association of Apolipoprotein E (Apo E) polymorphism with the prevalence of metabolic syndrome (MetS): the National Heart, Lung and Blood Institute Family Heart Study. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/17153

Chicago Manual of Style (16^th Edition):

Lai, Lana Yin Hui. “Association of Apolipoprotein E (Apo E) polymorphism with the prevalence of metabolic syndrome (MetS): the National Heart, Lung and Blood Institute Family Heart Study.” 2013. Masters Thesis, Boston University. Accessed January 24, 2021. http://hdl.handle.net/2144/17153.

MLA Handbook (7^th Edition):

Lai, Lana Yin Hui. “Association of Apolipoprotein E (Apo E) polymorphism with the prevalence of metabolic syndrome (MetS): the National Heart, Lung and Blood Institute Family Heart Study.” 2013. Web. 24 Jan 2021.

Vancouver:

Lai LYH. Association of Apolipoprotein E (Apo E) polymorphism with the prevalence of metabolic syndrome (MetS): the National Heart, Lung and Blood Institute Family Heart Study. [Internet] [Masters thesis]. Boston University; 2013. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/2144/17153.

Council of Science Editors:

Lai LYH. Association of Apolipoprotein E (Apo E) polymorphism with the prevalence of metabolic syndrome (MetS): the National Heart, Lung and Blood Institute Family Heart Study. [Masters Thesis]. Boston University; 2013. Available from: http://hdl.handle.net/2144/17153

University of Western Ontario

28. Cuddy, Leah K. Regulation of the High-Affinity Choline Transporter Activity and Trafficking in Alzheimer’s Disease-Related Pathological Conditions.

Degree: 2014, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/2513

► Cholinergic neurons play a key role in cognitive processes through the action of the neurotransmitter acetylcholine (ACh). Dysfunction of these neurons occurs in several neurodegenerative… (more)

▼ Cholinergic neurons play a key role in cognitive processes through the action of the neurotransmitter acetylcholine (ACh). Dysfunction of these neurons occurs in several neurodegenerative disorders, including Alzheimer’s disease (AD). The high-affinity choline transporter CHT recycles choline back into synaptic terminals, which is the rate-limiting step to ACh production. CHT proteins traffic between the cell surface and subcellular organelles in a constitutive manner, which maintains plasma membrane transporter levels, thereby regulating CHT activity and maintaining cholinergic transmission. Pathological conditions associated with AD may alter CHT function in a manner that reduces choline uptake activity and impairs cholinergic neurotransmission. Thus, my experiments focused on understanding the mechanisms regulating the subcellular distribution and activity of CHT in neural cells stably expressing the transporter exposed to AD-related pathological conditions. Important AD risk factors that can lead to pathological changes in the cholinergic nerve terminal microenvironment include increased generation of the reactive oxygen species (ROS) peroxynitrite (ONOO-), high serum cholesterol level at midlife and mutations in genes encoding the amyloid precursor protein (APP). My investigation revealed that ONOO- alters CHT function through changes to CHT subcellular trafficking, as opposed to nitrosative or oxidative modification to CHT itself. Moreover, CHT movement through subcellular endosomes and lysosomes was not altered by ONOO-, but blocking proteasome function attenuated ONOO- mediated inhibition of CHT function. Second, I evaluated how CHT activity and trafficking is regulated by plasma membrane cholesterol and its association with cholesterol-rich lipid rafts. The results of these experiments showed that membrane cholesterol and lipid rafts play an important role in regulating CHT trafficking and activity by retaining functional CHT at the cell surface. Finally, my studies revealed that CHT function is inhibited by both wild-type and Swedish mutant APP but the underlying mechanisms differ. Wild-type APP facilitates CHT endocytosis, whereas Swedish mutant APP mediated inhibition of CHT function is caused by the susceptibility of CHT to Aβ released into the extracellular environment. My studies help define the molecular regulation of CHT proteins under pathological conditions. Information from studies such as these will aid the design of therapeutic strategies to treat pathologies involving cholinergic dysfunction.

Subjects/Keywords: Alzheimer’s disease; cholinergic neurons; high-affinity choline transporter; oxidative stress; cholesterol; amyloid precursor protein; Medical Molecular Biology; Medical Pharmacology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cuddy, L. K. (2014). Regulation of the High-Affinity Choline Transporter Activity and Trafficking in Alzheimer’s Disease-Related Pathological Conditions. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/2513

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cuddy, Leah K. “Regulation of the High-Affinity Choline Transporter Activity and Trafficking in Alzheimer’s Disease-Related Pathological Conditions.” 2014. Thesis, University of Western Ontario. Accessed January 24, 2021. https://ir.lib.uwo.ca/etd/2513.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cuddy, Leah K. “Regulation of the High-Affinity Choline Transporter Activity and Trafficking in Alzheimer’s Disease-Related Pathological Conditions.” 2014. Web. 24 Jan 2021.

Vancouver:

Cuddy LK. Regulation of the High-Affinity Choline Transporter Activity and Trafficking in Alzheimer’s Disease-Related Pathological Conditions. [Internet] [Thesis]. University of Western Ontario; 2014. [cited 2021 Jan 24]. Available from: https://ir.lib.uwo.ca/etd/2513.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cuddy LK. Regulation of the High-Affinity Choline Transporter Activity and Trafficking in Alzheimer’s Disease-Related Pathological Conditions. [Thesis]. University of Western Ontario; 2014. Available from: https://ir.lib.uwo.ca/etd/2513

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

29. Chen, Yinan. Characterization of oxysterols produced in macrophages and mechanisms of regulation : Caractérisation des oxystérols produites dans les macrophages et les mécanismes de régulation.

Degree: Docteur es, Biochimie, 2016, Lyon

URL: http://www.theses.fr/2016LYSEI102

►

Les macrophages jouent un rôle clé dans l'athérosclérose. Après la captation massive des LDL oxydées (oxLDL), les macrophages sous-endothéliaux sont chargés en cholestérol et se… (more)

▼

Les macrophages jouent un rôle clé dans l'athérosclérose. Après la captation massive des LDL oxydées (oxLDL), les macrophages sous-endothéliaux sont chargés en cholestérol et se transforment ainsi en cellules spumeuses qui contribuent à la formation de la plaque d'athérome. Les oxystérols, produits d'oxydation du cholestérol, sont retrouvés en quantité importante dans les oxLDL. Au niveau cellulaire, ils sont impliqués dans la régulation de l'homéostasie du cholestérol, l'induction du stress oxydatif cellulaire et de la cytotoxicité. Notre travail montre que le cholestérol, associé aux LDL et d'origine cellulaire, est fortement oxydé par les macrophages lors d'une exposition aux oxLDL. Les principaux produits d'oxydation sont le 7-cétocholesterol et 7α/β-hydroxycholestérol. De plus, nous démontrons que ces oxystérols sont exportés hors des macrophages via les HDL, mais pas l'apoA1. Nous avons aussi caractérisé les oxystérols formés dans les HDL suite à des modifications oxydatives et les HDL issues de patients diabétiques. Nous avons en outre montré que ces modifications sont associées à une diminution de la capacité des HDL à exporter les oxystérols.

Macrophages play a key role in atherosclerosis. After massive uptake of oxidized LDL (oxLDL), subendothelial macrophages are overloaded with cholesterol thereby leading to the formation of foam cells, which is one characteristic of atherogenesis. Oxysterols, the oxidation products of cholesterol, are one of major components of oxLDL; they are involved in the regulation of cholesterol homeostasis, induction of cellular oxidative stress and cytotoxicity. Our works show that both LDL derived-cholesterol and cellular cholesterol can be strongly oxidized in human THP1 and murine RAW macrophages, especially during exposure of oxLDL. The major oxidative products are 7-ketocholesterol and 7α/β-hydroxycholesterol. Moreover, we demonstrate that both oxysterols derived from LDL cholesterol and cellular cholesterol can be exported to HDL, whereas not to apoA1. Then, we studied the functionality of modified HDL and diabetic HDL on oxysterols efflux. A decrease of oxysterols efflux was observed with oxidized and glycoxidized HDL. Compared to the HDL of healthy controls, the HDL of diabetic subjects are less efficient to efflux oxysterols. Taken together, the increased production of oxysterols in presence of oxLDL and their lower efflux by modified HDL support the detrimental role of these oxidative compounds in pathophysiological conditions like diabetes.

Advisors/Committee Members: Vandenbroucke, Isabelle (thesis director).

Subjects/Keywords: Biosciences; Lipoprotéines; Cholestérol; Athérosclérose; Lipoprotéines de haute densité; Biosciences; Lipoproteins; Cholesterol; Atherosclerosis; High density lipoproteins; 572.507 2

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chen, Y. (2016). Characterization of oxysterols produced in macrophages and mechanisms of regulation : Caractérisation des oxystérols produites dans les macrophages et les mécanismes de régulation. (Doctoral Dissertation). Lyon. Retrieved from http://www.theses.fr/2016LYSEI102

Chicago Manual of Style (16^th Edition):

Chen, Yinan. “Characterization of oxysterols produced in macrophages and mechanisms of regulation : Caractérisation des oxystérols produites dans les macrophages et les mécanismes de régulation.” 2016. Doctoral Dissertation, Lyon. Accessed January 24, 2021. http://www.theses.fr/2016LYSEI102.

MLA Handbook (7^th Edition):

Chen, Yinan. “Characterization of oxysterols produced in macrophages and mechanisms of regulation : Caractérisation des oxystérols produites dans les macrophages et les mécanismes de régulation.” 2016. Web. 24 Jan 2021.

Vancouver:

Chen Y. Characterization of oxysterols produced in macrophages and mechanisms of regulation : Caractérisation des oxystérols produites dans les macrophages et les mécanismes de régulation. [Internet] [Doctoral dissertation]. Lyon; 2016. [cited 2021 Jan 24]. Available from: http://www.theses.fr/2016LYSEI102.

Council of Science Editors:

Chen Y. Characterization of oxysterols produced in macrophages and mechanisms of regulation : Caractérisation des oxystérols produites dans les macrophages et les mécanismes de régulation. [Doctoral Dissertation]. Lyon; 2016. Available from: http://www.theses.fr/2016LYSEI102

30. LOKE SAU YEEN. CHOLESTEROL INDUCED GENE EXPRESSION CHANGES IN THE BRAIN AND CEREBRAL VESSELS.

Degree: 2015, National University of Singapore

URL: http://scholarbank.nus.edu.sg/handle/10635/120416

Subjects/Keywords: Cholesterol; oxysterol; Alzheimer's disease; stroke; ICLAD; high blood pressure

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

YEEN, L. S. (2015). CHOLESTEROL INDUCED GENE EXPRESSION CHANGES IN THE BRAIN AND CEREBRAL VESSELS. (Thesis). National University of Singapore. Retrieved from http://scholarbank.nus.edu.sg/handle/10635/120416

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

YEEN, LOKE SAU. “CHOLESTEROL INDUCED GENE EXPRESSION CHANGES IN THE BRAIN AND CEREBRAL VESSELS.” 2015. Thesis, National University of Singapore. Accessed January 24, 2021. http://scholarbank.nus.edu.sg/handle/10635/120416.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

YEEN, LOKE SAU. “CHOLESTEROL INDUCED GENE EXPRESSION CHANGES IN THE BRAIN AND CEREBRAL VESSELS.” 2015. Web. 24 Jan 2021.

Vancouver:

YEEN LS. CHOLESTEROL INDUCED GENE EXPRESSION CHANGES IN THE BRAIN AND CEREBRAL VESSELS. [Internet] [Thesis]. National University of Singapore; 2015. [cited 2021 Jan 24]. Available from: http://scholarbank.nus.edu.sg/handle/10635/120416.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

YEEN LS. CHOLESTEROL INDUCED GENE EXPRESSION CHANGES IN THE BRAIN AND CEREBRAL VESSELS. [Thesis]. National University of Singapore; 2015. Available from: http://scholarbank.nus.edu.sg/handle/10635/120416

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations