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University of Hong Kong
1.
Seto, Wai-kay, Walter.
Virologic and serologic kinetics in the natural history
and treatment of chronic hepatitis B.
Degree: Doctor of Medicine, 2012, University of Hong Kong
URL: Seto,
W.
W.
[司徒偉基].
(2012).
Virologic
and
serologic
kinetics
in
the
natural
history
and
treatment
of
chronic
hepatitis
B.
(Thesis).
University
of
Hong
Kong,
Pokfulam,
Hong
Kong
SAR.
Retrieved
from
http://dx.doi.org/10.5353/th_b4867107 
;
http://dx.doi.org/10.5353/th_b4867107
;
http://hdl.handle.net/10722/180104
► This thesis investigated how virologic and serologic kinetics of the hepatitis B virus (HBV) could influence the natural history and treatment of chronic hepatitis B…
(more)
▼ This thesis investigated how virologic and
serologic kinetics of the hepatitis B virus (HBV) could influence
the natural history and treatment of chronic hepatitis B (CHB).
Virologic kinetics were described in the first five studies, with
serologic kinetics being described in the next five.
The first
study delineated the HBV DNA profiles of 1,400 treatment-naive
Asian CHB patients. Increasing viremia was noted with increasing
age, highlighting the large therapeutic demand in Asian patients
with hepatitis B e antigen (HBeAg)-negative CHB. The second study
analyzed the association between viral load and liver histology in
319 patients, showing HBV DNA levels to have strong association
with HBeAg-negative disease severity.
The next three studies
investigated the efficacy of baseline and on-treatment HBV DNA
levels in predicting clinical outcomes in 117, 165 and 222 patients
on telbivudine, lamivudine plus adefovir and entecavir
respectively. Absolute on-treatment HBV DNA levels at week 12 or 24
predicted favorable outcome with telbivudine and lamivudine /
adefovir therapy, while excellent viremic suppression with very low
rate of resistance development was shown in the entecavir study.
The following three studies examined the role of serum HBsAg
measurements in different disease phases of CHB. First, histology
specimens of 140 HBeAg-positive patients were analyzed together
with HBsAg levels. High HBsAg titers (>25,000 IU/mL) were found
to be predictive of insignificant fibrosis. In the next study
involving 300 treatment-naive HBeAg-negative patients stratified by
their viral loads, combination of low HBsAg and HBV DNA levels
predicted significant HBsAg decline. This is followed by a study
comparing HBsAg levels of 203 CHB patients achieving HBsAg
seroclearance with 203 age- and sex-matched controls over a 3-year
period. Serum HBsAg <200 IU/mL and a significant annual HBsAg
reduction were found to be predictive of HBsAg seroclearance.
The
penultimate study investigated the usage of two novel HBV serologic
markers, linearized HBsAg and hepatitis B core-related antigen, in
329 CHB patients achieving HBsAg seroclearance with a conventional
HBsAg assay. More than 40% of patients had seropositivity to one or
both serologic tests. Finally, the last study of this thesis
investigated and compared the changes in serum HBsAg, intrahepatic
HBV DNA and covalently closed circular DNA (cccDNA) after 1 year of
nucleoside analogue therapy. Minimal changes in both serum HBsAg
and intrahepatic cccDNA were noted after 1 year of therapy, but in
patients with a significant decline in serum HBsAg levels, there
was a corresponding significant reduction in cccDNA.
This series
of studies illustrated how the monitoring of serum HBV DNA and
HBsAg levels could assist in optimizing management strategies for
CHB.
published_or_final_version
Medicine
Master
Doctor of Medicine
Subjects/Keywords: Hepatitis B.; Hepatitis B virus.
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APA (6th Edition):
Seto, Wai-kay, W. (2012). Virologic and serologic kinetics in the natural history
and treatment of chronic hepatitis B. (Doctoral Dissertation). University of Hong Kong. Retrieved from Seto, W. W. [司徒偉基]. (2012). Virologic and serologic kinetics in the natural history and treatment of chronic hepatitis B. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4867107 ; http://dx.doi.org/10.5353/th_b4867107 ; http://hdl.handle.net/10722/180104
Chicago Manual of Style (16th Edition):
Seto, Wai-kay, Walter. “Virologic and serologic kinetics in the natural history
and treatment of chronic hepatitis B.” 2012. Doctoral Dissertation, University of Hong Kong. Accessed December 10, 2019.
Seto, W. W. [司徒偉基]. (2012). Virologic and serologic kinetics in the natural history and treatment of chronic hepatitis B. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4867107 ; http://dx.doi.org/10.5353/th_b4867107 ; http://hdl.handle.net/10722/180104.
MLA Handbook (7th Edition):
Seto, Wai-kay, Walter. “Virologic and serologic kinetics in the natural history
and treatment of chronic hepatitis B.” 2012. Web. 10 Dec 2019.
Vancouver:
Seto, Wai-kay W. Virologic and serologic kinetics in the natural history
and treatment of chronic hepatitis B. [Internet] [Doctoral dissertation]. University of Hong Kong; 2012. [cited 2019 Dec 10].
Available from: Seto, W. W. [司徒偉基]. (2012). Virologic and serologic kinetics in the natural history and treatment of chronic hepatitis B. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4867107 ; http://dx.doi.org/10.5353/th_b4867107 ; http://hdl.handle.net/10722/180104.
Council of Science Editors:
Seto, Wai-kay W. Virologic and serologic kinetics in the natural history
and treatment of chronic hepatitis B. [Doctoral Dissertation]. University of Hong Kong; 2012. Available from: Seto, W. W. [司徒偉基]. (2012). Virologic and serologic kinetics in the natural history and treatment of chronic hepatitis B. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4867107 ; http://dx.doi.org/10.5353/th_b4867107 ; http://hdl.handle.net/10722/180104
University of Melbourne
2.
Lim, Lucy.
The role of Hepatitis B surface antigen in the development of severe liver disease and hepatocellular carcinoma.
Degree: 2016, University of Melbourne
URL: http://hdl.handle.net/11343/129770
► Hepatitis B virus (HBV) infection continues to be a major public health issue worldwide, affecting an estimated 2 billion people globally. In spite of safe…
(more)
▼ Hepatitis B virus (HBV) infection continues to be a major public health issue worldwide, affecting an estimated 2 billion people globally. In spite of safe vaccination and effective therapy, there is still a large burden of disease due to chronic hepatitis B (CHB), affecting an estimated 240 million people, which may lead to cirrhosis and or the development of hepatocellular carcinoma (HCC). Liver cancer is rapidly emerging as the single greatest challenge in hepatology and liver transplantation and the burden of disease is set to explode in the next 20-30 years.
Viral hepatitis is ranked as the seventh leading cause of death worldwide, resulting in at least 1.2 million deaths annually from liver cirrhosis and HCC. HCC is currently the sixth most common cancer and the second leading cause of cancer-related deaths globally. Case-control studies have shown that chronic HBV carriers have more than 100-fold increased risk of HCC compared with non-infected individuals. Approximately 80% of all HCC cases can be attributed to viral hepatitis, more than half of that due to HBV, which is the second most potent carcinogen after tobacco (World Health Organization), and this is despite remarkable improvement in therapy with the advent of nucleos(t)ide analogues (NA).
The global reservoir of HBV infection serves as the basis for the generation of HBV variants via recombination and a high frequency of mutation in the HBV genome. Due to the inherent molecular biology of this virus which replicates its DNA genome via a low fidelity viral reverse transcriptase (rt)/polymerase, a population of closely related genetic variants known as a quasispecies is produced. The last two decades have seen a significant increase in the emergence of mutants as the virus responds to selective pressures, such as vaccination and antiviral therapy. Surveillance for clinically significant HBV mutations and an improved understanding of the impact of these emerging variants on the natural history of the disease and its diagnosis, control and management will pose a challenge to global health care in the foreseeable future. This is because these mutants have the potential to alter current diagnostic and treatment algorithms.
NA therapy was approved in 1998, which efficiently lowers the HBV DNA viral load in HBV-infected patients. Given that the HCC risk is particularly high in the presence of cirrhosis and/or persistent high HBV DNA replication, NA should be a rational treatment to prevent liver disease progression including liver cancer in such patients. However since the introduction of antiviral therapy, the HCC incidence has continued to rise. Registration for the liver transplant waiting list due to HBV-related HCC in the U.S. has increased in the NA era, which may in part be due to patients no longer dying of liver disease. There is clearly a need for a greater understanding of the role that NA therapy might play in the development of HCC.
Numerous risk factors for HBV-related HCC development have been identified. However the…
Subjects/Keywords: Hepatitis B
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APA (6th Edition):
Lim, L. (2016). The role of Hepatitis B surface antigen in the development of severe liver disease and hepatocellular carcinoma. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/129770
Chicago Manual of Style (16th Edition):
Lim, Lucy. “The role of Hepatitis B surface antigen in the development of severe liver disease and hepatocellular carcinoma.” 2016. Doctoral Dissertation, University of Melbourne. Accessed December 10, 2019.
http://hdl.handle.net/11343/129770.
MLA Handbook (7th Edition):
Lim, Lucy. “The role of Hepatitis B surface antigen in the development of severe liver disease and hepatocellular carcinoma.” 2016. Web. 10 Dec 2019.
Vancouver:
Lim L. The role of Hepatitis B surface antigen in the development of severe liver disease and hepatocellular carcinoma. [Internet] [Doctoral dissertation]. University of Melbourne; 2016. [cited 2019 Dec 10].
Available from: http://hdl.handle.net/11343/129770.
Council of Science Editors:
Lim L. The role of Hepatitis B surface antigen in the development of severe liver disease and hepatocellular carcinoma. [Doctoral Dissertation]. University of Melbourne; 2016. Available from: http://hdl.handle.net/11343/129770
University of Hong Kong
3.
Zhu, Sheng.
Effect of the health belief model in explaining HBV
screening and vaccination health behaviour : a systematic
review.
Degree: MPH, 2013, University of Hong Kong
URL: Zhu,
S.
[朱晟].
(2013).
Effect
of
the
health
belief
model
in
explaining
HBV
screening
and
vaccination
health
behaviour
:
a
systematic
review.
(Thesis).
University
of
Hong
Kong,
Pokfulam,
Hong
Kong
SAR.
Retrieved
from
http://dx.doi.org/10.5353/th_b5099022
;
http://dx.doi.org/10.5353/th_b5099022
;
http://hdl.handle.net/10722/193831
► Objectives To systematically review all studies HBV screening and vaccination health behaviour according to the Health Belief Model theoretical framework including perceived susceptibility, severity, barriers…
(more)
▼ Objectives
To systematically review all studies
HBV screening and vaccination health behaviour according to the
Health Belief Model theoretical framework including perceived
susceptibility, severity, barriers and benefits, cues to action and
self-efficacy.
Methodology
The literature search used PUBMED,
MEDLINE, CINAHL plus, Wan Fang database, and Chinese Journal Net
with English and Chinese language. About 73 studies (PUBMED: 33
MEDLINE: 10, CINAHL plus: 3, Wan Fang database: 16, Chinese journal
net: 11) in total were identified; after applying the inclusion and
exclusion criteria, 11 studies met the criteria and in the final
analysis. The target group included high infection rate groups
(pregnant women, unprotected sexual behaviour, and immigrant group)
and illness groups (chronic Hepatitis B and Hepatitis B virus
carriers).
Results and Discussion
HBV screening and vaccination
behaviour were determined by perceived the susceptibility,
perceived severity, perceived barriers and benefits, and cues to
action. The self-efficacy was seldom designed in the questionnaire
of the reviewed articles. The Health belief model was a useful
model for explaining HBV screening and vaccination behaviour.
Screening- and vaccination-related beliefs of the screening and
vaccination vary by high risk groups. From the review more
attention to self-efficacy and perceived control may improve
vaccination uptake. There were contrast results with the social
economic characteristics, such as age, gender, income, in
determining the HBV screening and vaccination behaviour.
Conclusion and Implication
As the policy maker, health care
providers need to develop specific interventions paying attention
to the different aspects of the Health Belief Model to improve the
perceived of Hepatitis B virus.
published_or_final_version
Public Health
Master
Master of Public Health
Subjects/Keywords: Hepatitis B - Diagnosis; Hepatitis B - Vaccination
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APA ·
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APA (6th Edition):
Zhu, S. (2013). Effect of the health belief model in explaining HBV
screening and vaccination health behaviour : a systematic
review. (Masters Thesis). University of Hong Kong. Retrieved from Zhu, S. [朱晟]. (2013). Effect of the health belief model in explaining HBV screening and vaccination health behaviour : a systematic review. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5099022 ; http://dx.doi.org/10.5353/th_b5099022 ; http://hdl.handle.net/10722/193831
Chicago Manual of Style (16th Edition):
Zhu, Sheng. “Effect of the health belief model in explaining HBV
screening and vaccination health behaviour : a systematic
review.” 2013. Masters Thesis, University of Hong Kong. Accessed December 10, 2019.
Zhu, S. [朱晟]. (2013). Effect of the health belief model in explaining HBV screening and vaccination health behaviour : a systematic review. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5099022 ; http://dx.doi.org/10.5353/th_b5099022 ; http://hdl.handle.net/10722/193831.
MLA Handbook (7th Edition):
Zhu, Sheng. “Effect of the health belief model in explaining HBV
screening and vaccination health behaviour : a systematic
review.” 2013. Web. 10 Dec 2019.
Vancouver:
Zhu S. Effect of the health belief model in explaining HBV
screening and vaccination health behaviour : a systematic
review. [Internet] [Masters thesis]. University of Hong Kong; 2013. [cited 2019 Dec 10].
Available from: Zhu, S. [朱晟]. (2013). Effect of the health belief model in explaining HBV screening and vaccination health behaviour : a systematic review. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5099022 ; http://dx.doi.org/10.5353/th_b5099022 ; http://hdl.handle.net/10722/193831.
Council of Science Editors:
Zhu S. Effect of the health belief model in explaining HBV
screening and vaccination health behaviour : a systematic
review. [Masters Thesis]. University of Hong Kong; 2013. Available from: Zhu, S. [朱晟]. (2013). Effect of the health belief model in explaining HBV screening and vaccination health behaviour : a systematic review. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5099022 ; http://dx.doi.org/10.5353/th_b5099022 ; http://hdl.handle.net/10722/193831
University of Helsinki
4.
Laivuori, Tove.
Lasten krooninen B- ja C-hepatiitti Helsingin ja Uudenmaan sairaanhoitopiirissä vuosina 1996-2006.
Degree: Institute of Clinical Medicine; Helsingfors universitet, Medicinska fakulteten, Institutionen för klinisk medicin, 2010, University of Helsinki
URL: http://hdl.handle.net/10138/16241
► Tutkimuksen tarkoituksena oli kartoittaa Helsingin ja Uudenmaan sairaanhoitopiirin (HUS) sairaaloissa hoidettujen lasten kroonisten B- ja C-hepatiittien tartuntareittejä ja tartunnan riskitekijöitä sekä selvittää, miten hepatiittien seuranta…
(more)
▼ Tutkimuksen tarkoituksena oli kartoittaa Helsingin ja Uudenmaan sairaanhoitopiirin (HUS) sairaaloissa hoidettujen lasten kroonisten B- ja C-hepatiittien tartuntareittejä ja tartunnan riskitekijöitä sekä selvittää, miten hepatiittien seuranta ja hoito on HUS-piirissä toteutunut. Tutkimusaineisto kerättiin retrospektiivisesti strukturoitua tiedonkeruulomaketta käyttäen HUS-piirin sairaaloiden ja HUSLAB:n arkisto- ja sairauskertomustiedostoja. Potilaiden valintakriteereinä olivat alle 16 vuoden ikä ja laboratoriotutkimuksin varmennettu krooninen B- tai C-hepatiitti vuosien 1996-2006 aikana. B-hepatiittia sairastavista lapsista 61/66 oli syntynyt Suomen ulkopuolella, ja valtaosa heidän tartunnoistaan todettiin maahantulotarkastuksen yhteydessä. C-hepatiittia sairastavista lapsista 28/40 oli syntynyt Suomessa. Maahantulotarkastus sekä päihteiden käyttöön liittyvä seulonta olivat tärkeimmät diagnoosiin johtaneet tutkimustilanteet. Antiviraalisesta lääkehoidosta hyötyi 6/13 B-hepatiittia ja 2/4 C-hepatiittia sairastavista lapsista. HUS-piirissä B-hepatiittia esiintyy lähinnä maahanmuuttajataustaisilla lapsilla. Krooninen C-hepatiitti liittyi lapsen tai hänen vanhempiensa huumeiden käyttöön. Tutkimus korostaa lasten B- ja C-hepatiitin seulonta-, seuranta- ja hoitokäytäntöjä selkeyttävän ohjeistuksen tarvetta.
Subjects/Keywords: Hepatitis B; Hepatitis C; child; Hepatitis B; Hepatitis C; child
Record Details
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APA ·
Chicago ·
MLA ·
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CSE |
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APA (6th Edition):
Laivuori, T. (2010). Lasten krooninen B- ja C-hepatiitti Helsingin ja Uudenmaan sairaanhoitopiirissä vuosina 1996-2006. (Masters Thesis). University of Helsinki. Retrieved from http://hdl.handle.net/10138/16241
Chicago Manual of Style (16th Edition):
Laivuori, Tove. “Lasten krooninen B- ja C-hepatiitti Helsingin ja Uudenmaan sairaanhoitopiirissä vuosina 1996-2006.” 2010. Masters Thesis, University of Helsinki. Accessed December 10, 2019.
http://hdl.handle.net/10138/16241.
MLA Handbook (7th Edition):
Laivuori, Tove. “Lasten krooninen B- ja C-hepatiitti Helsingin ja Uudenmaan sairaanhoitopiirissä vuosina 1996-2006.” 2010. Web. 10 Dec 2019.
Vancouver:
Laivuori T. Lasten krooninen B- ja C-hepatiitti Helsingin ja Uudenmaan sairaanhoitopiirissä vuosina 1996-2006. [Internet] [Masters thesis]. University of Helsinki; 2010. [cited 2019 Dec 10].
Available from: http://hdl.handle.net/10138/16241.
Council of Science Editors:
Laivuori T. Lasten krooninen B- ja C-hepatiitti Helsingin ja Uudenmaan sairaanhoitopiirissä vuosina 1996-2006. [Masters Thesis]. University of Helsinki; 2010. Available from: http://hdl.handle.net/10138/16241
University of Hong Kong
5.
Lin, Shing-cho.
Hepatitis B virus covalently closed circular DNA is
associated with methylated histones H3 and H4 and heterochromatin
complex proteins : implication of their roles in viral
replication.
Degree: M. Phil., 2013, University of Hong Kong
URL: Lin,
S.
[連承祖].
(2013).
Hepatitis
B
virus
covalently
closed
circular
DNA
is
associated
with
methylated
histones
H3
and
H4
and
heterochromatin
complex
proteins
:
implication
of
their
roles
in
viral
replication.
(Thesis).
University
of
Hong
Kong,
Pokfulam,
Hong
Kong
SAR.
Retrieved
from
http://dx.doi.org/10.5353/th_b5137974
;
http://dx.doi.org/10.5353/th_b5137974
;
http://hdl.handle.net/10722/194622
► Hepatitis B virus covalently closed circular DNA (HBV cccDNA) forms a mini-chromosome structure inside infected hepatocyte nuclei and plays an important role in chronic hepatitis…
(more)
▼ Hepatitis B virus covalently closed circular DNA
(HBV cccDNA) forms a mini-chromosome structure inside infected
hepatocyte nuclei and plays an important role in chronic hepatitis
B infection. Methylation of cccDNA-bound histone and the
associations of heterochromatin HP1 complex related proteins with
cccDNA were investigated in this thesis using transient
transfection study system and chromatin immunoprecipitation assay.
Di- and tri-methylation of histone H3 lysine 4 residue (H3K4),
which plays an activating role in eukaryotic transcription, were
found to associate with cccDNA in a way in parallel to the level of
HBV replication in our system. On the other hand, tri-methylation
of H3K9, which plays an inhibitory role in eukaryotic
transcription, was found to associate with cccDNA during decline of
HBV replication. During the decline of HBV replication, cccDNA was
associated with histone methyltransferases SUV39H1 and SUV420H1 and
histone demethylase PLU1.
The dynamic of the association of
heterochromatin protein 1 (HP1) to cccDNA was similar to that of
SUV39H1. The association of cccDNA with five HP1 complex-related
proteins (three DNA methyltransferases Dnmt3a, Dnmt3b and Dnmt1 and
two methylated DNA binding proteins MBD1 and MeCP2) was studied,
and their associations could be roughly divided into two stages.
From 72 hours to 96 hours post-transfection, there was an increased
association of cccDNA with Dnmt3a, Dnmt3b and MBD1, which was in
parallel to the increased association of HP1 and SUV39H1with
-cccDNA. From 96 hours to 120 hours after transfection, an
increased association of Dnmt1 and MeCP2 with cccDNA was detected,
which was correlated to that of SUV420H1. At the time when HBV
replication was declining at 120 hours post-transfection, a highest
association of SUV39H1, SUV420H1, HP1 and all 5 HP1 complex-related
proteins with cccDNA was found.
In conclusion, methylation of
cccDNA-bound histone was associated with HBV replication.
Activating H3K4 methylation was found to correlate with increase in
HBV replication, while inhibitory H3K9 methylation correlated with
decrease in HBV replication. The association of HP1 was in parallel
to that of SUV39H1, indicating that HP1-SUV39H1 complex might be
involved, and thereby recruiting other proteins for transcription
suppression. Recruitment of DNA methyltransferases and methylated
DNA binding proteins to cccDNA provided further evidence that
methylation of cccDNA plays a role in transcription suppression.
This study identified the associations of methylated histone and
other related proteins with cccDNA and their correlations with
viral replication. These results enhance our knowledge in HBV
replication cycles and transcription regulation. It may show a
novel area in development of antiviral drugs such as histone
methyltransferase modulators.
published_or_final_version
Medicine
Master
Master of Philosophy
Subjects/Keywords: Hepatitis B virus
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APA ·
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MLA ·
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CSE |
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Manager
APA (6th Edition):
Lin, S. (2013). Hepatitis B virus covalently closed circular DNA is
associated with methylated histones H3 and H4 and heterochromatin
complex proteins : implication of their roles in viral
replication. (Masters Thesis). University of Hong Kong. Retrieved from Lin, S. [連承祖]. (2013). Hepatitis B virus covalently closed circular DNA is associated with methylated histones H3 and H4 and heterochromatin complex proteins : implication of their roles in viral replication. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5137974 ; http://dx.doi.org/10.5353/th_b5137974 ; http://hdl.handle.net/10722/194622
Chicago Manual of Style (16th Edition):
Lin, Shing-cho. “Hepatitis B virus covalently closed circular DNA is
associated with methylated histones H3 and H4 and heterochromatin
complex proteins : implication of their roles in viral
replication.” 2013. Masters Thesis, University of Hong Kong. Accessed December 10, 2019.
Lin, S. [連承祖]. (2013). Hepatitis B virus covalently closed circular DNA is associated with methylated histones H3 and H4 and heterochromatin complex proteins : implication of their roles in viral replication. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5137974 ; http://dx.doi.org/10.5353/th_b5137974 ; http://hdl.handle.net/10722/194622.
MLA Handbook (7th Edition):
Lin, Shing-cho. “Hepatitis B virus covalently closed circular DNA is
associated with methylated histones H3 and H4 and heterochromatin
complex proteins : implication of their roles in viral
replication.” 2013. Web. 10 Dec 2019.
Vancouver:
Lin S. Hepatitis B virus covalently closed circular DNA is
associated with methylated histones H3 and H4 and heterochromatin
complex proteins : implication of their roles in viral
replication. [Internet] [Masters thesis]. University of Hong Kong; 2013. [cited 2019 Dec 10].
Available from: Lin, S. [連承祖]. (2013). Hepatitis B virus covalently closed circular DNA is associated with methylated histones H3 and H4 and heterochromatin complex proteins : implication of their roles in viral replication. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5137974 ; http://dx.doi.org/10.5353/th_b5137974 ; http://hdl.handle.net/10722/194622.
Council of Science Editors:
Lin S. Hepatitis B virus covalently closed circular DNA is
associated with methylated histones H3 and H4 and heterochromatin
complex proteins : implication of their roles in viral
replication. [Masters Thesis]. University of Hong Kong; 2013. Available from: Lin, S. [連承祖]. (2013). Hepatitis B virus covalently closed circular DNA is associated with methylated histones H3 and H4 and heterochromatin complex proteins : implication of their roles in viral replication. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5137974 ; http://dx.doi.org/10.5353/th_b5137974 ; http://hdl.handle.net/10722/194622
University of Adelaide
6.
Teoh, Chee Quin (Devin).
Development and assessment of novel vaccination strategies for hepatitis B virus infection.
Degree: 2014, University of Adelaide
URL: http://hdl.handle.net/2440/92807
► The current hepatitis B virus (HBV) vaccine is of no benefit in the treatment of patients with chronic HBV infection, and current antiviral therapies which…
(more)
▼ The current
hepatitis B virus (HBV) vaccine is of no benefit in the treatment of patients with chronic HBV infection, and current antiviral therapies which inhibit the virus polymerase are not highly effective. The ultimate aim of this Ph.D. project was to develop and assess therapeutic vaccination strategies that induce immune responses that target virus infected hepatocytes and allow successful control of chronic HBV infection. To this end, a number of vaccination strategies were tested using the duck
hepatitis B virus (DHBV) model. The DHBV model provides a versatile and reproducible experimental system for testing vaccination strategies as the outcomes of DHBV infection in ducks of different ages infected with different doses of virus have been well characterised. In initial studies described in Chapter 3, recombinant DHBV core antigen (rDHBcAg) expressed in E. coli, was purified and used to immunise rabbits and mice to produce specific polyclonal and monoclonal antibodies for the detection of DHBV core antigen (DHBcAg). Immuno-staining techniques using these anti-DHBcAg-specific antibodies were then optimised. Immunoperoxidase detection of DHBcAg in duck liver sections was an essential part of this analysis as it allowed comparison with detection of DHBV surface antigen (DHBsAg) and confirmation of the percentage of DHBV-infected hepatocytes. Western Blot and immunofluorescent detection of DHBcAg were also developed and optimised and then all 3 immuno-staining techniques were used in subsequent Chapters to assess the efficacy of the different vaccination strategies. As described in Chapter 4, duck CD40L (DuCD40L), was assessed as an immunological adjuvant in a protective DNA vaccine study. In humans, CD40L acts as a co-stimulatory molecule in the CD40-signalling pathway that is involved in the activation of antigen presenting cells (APC) and the generation of humoral and cell mediated immune (CMI) responses. In the current studies the DuCD40L cDNA sequence was cloned using mRNA from duck peripheral blood mononuclear cells (PBMC) into the expression construct, pcDNA3, to yield pcDNA3-DuCD40L. Cells and supernatants of cells transfected with pcDNA3-DuCD40L were subsequently tested for bioactivity using in vitro assays. The cloning and analysis of expression of the DuCD40L was performed in our laboratory by Dr Feng Feng. The DuCD40L expression construct was then co-administered intramuscularly with DNA vaccines expressing the DHBV surface and core antigens to ducks at 14 and 28 days of age. Two weeks after the second vaccination, ducks were challenged intravenously (i.v.) with 4.5x10¹⁰ DHBV genomes. Administration of the DuCD40L expression construct and the DHBV DNA vaccines in combination resulted in a 10-fold greater anti-DHBs antibody response and a significant decrease in the number of DHBV-infected hepatocytes at day 4 post-challenge (p.c.) compared to ducks that received DHBV DNA vaccines alone. Ultimately, as expected, all of the ducks successfully cleared their DHBV infection. Nevertheless, we determined…
Advisors/Committee Members: Jilbert, Allison Rae (advisor), Feng, Feng (advisor), School of Molecular and Biomedical Science (school).
Subjects/Keywords: Hepatitis B; Vaccination
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APA (6th Edition):
Teoh, C. Q. (. (2014). Development and assessment of novel vaccination strategies for hepatitis B virus infection. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/92807
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Teoh, Chee Quin (Devin). “Development and assessment of novel vaccination strategies for hepatitis B virus infection.” 2014. Thesis, University of Adelaide. Accessed December 10, 2019.
http://hdl.handle.net/2440/92807.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Teoh, Chee Quin (Devin). “Development and assessment of novel vaccination strategies for hepatitis B virus infection.” 2014. Web. 10 Dec 2019.
Vancouver:
Teoh CQ(. Development and assessment of novel vaccination strategies for hepatitis B virus infection. [Internet] [Thesis]. University of Adelaide; 2014. [cited 2019 Dec 10].
Available from: http://hdl.handle.net/2440/92807.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Teoh CQ(. Development and assessment of novel vaccination strategies for hepatitis B virus infection. [Thesis]. University of Adelaide; 2014. Available from: http://hdl.handle.net/2440/92807
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Georgia Tech
7.
Perez Cuevas, Monica Beatriz.
Hepatitis B vaccination using a dissolvable microneedle patch.
Degree: MS, Chemical and Biomolecular Engineering, 2017, Georgia Tech
URL: http://hdl.handle.net/1853/59807
► Despite improved vaccination rates against hepatitis B, there remain critical barriers to addressing gaps in vaccination coverage. The need of an effective supply chain, vaccine…
(more)
▼ Despite improved vaccination rates against
hepatitis B, there remain critical barriers to addressing gaps in vaccination coverage. The need of an effective supply chain, vaccine waste management, trained healthcare providers and cost are all issues that impede mass vaccination campaigns around the world. Microneedle patches have been proposed as an alternative mode of vaccination. Microneedle patches consist of micron-scale projections that are capable of disrupting the stratum corneum by creating holes in the skin to deliver therapeutic agents. Small and lightweight, microneedle patches are a promising alternative to the bulky multi-dose vials and syringes currently used in mass vaccination campaigns. Furthermore, the high density of antigen presenting cells in the the skin make transcutaneous immunization via microneedles advantageous, as they target vaccine cargo to the topmost layer of the skin. The key goal of this project was to develop a microneedle patch for
hepatitis B vaccination that is simple to administer and of comparable immunogenicity to conventional intramuscular vaccination. Trehalose was used as a stabilizing excipient for both coated metal and dissolvable microneedles. Moreover, patches were used in vivo to compare the elicited immune response in both mice and rhesus macaques. Additionally, the mechanical properties of our microneedle patch were evaluated via both theoretical and experimental approaches to predict failure force. This work shows that microneedle patches can successfully encapsulate and deliver
hepatitis B antigen to generate a strong and sustained immune response in multiple animal models.
Advisors/Committee Members: Prausnitz, Mark R. (advisor), Garcia, Andres J. (committee member), Bommarius, Andreas S. (committee member).
Subjects/Keywords: Microneedles; Hepatitis b
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APA (6th Edition):
Perez Cuevas, M. B. (2017). Hepatitis B vaccination using a dissolvable microneedle patch. (Masters Thesis). Georgia Tech. Retrieved from http://hdl.handle.net/1853/59807
Chicago Manual of Style (16th Edition):
Perez Cuevas, Monica Beatriz. “Hepatitis B vaccination using a dissolvable microneedle patch.” 2017. Masters Thesis, Georgia Tech. Accessed December 10, 2019.
http://hdl.handle.net/1853/59807.
MLA Handbook (7th Edition):
Perez Cuevas, Monica Beatriz. “Hepatitis B vaccination using a dissolvable microneedle patch.” 2017. Web. 10 Dec 2019.
Vancouver:
Perez Cuevas MB. Hepatitis B vaccination using a dissolvable microneedle patch. [Internet] [Masters thesis]. Georgia Tech; 2017. [cited 2019 Dec 10].
Available from: http://hdl.handle.net/1853/59807.
Council of Science Editors:
Perez Cuevas MB. Hepatitis B vaccination using a dissolvable microneedle patch. [Masters Thesis]. Georgia Tech; 2017. Available from: http://hdl.handle.net/1853/59807
University of Zambia
8.
Mungandi, Namwaka.
Hepatitis B Vaccination coverage and the determinants of vaccination in Health Care Workers in seleted Health facilities
.
Degree: 2017, University of Zambia
URL: http://dspace.unza.zm:8080/xmlui/handle/123456789/4868
► Background: Hepatitis B is a viral infection of the liver and causes both acute and chronic disease. It is transmitted through contact with an infected…
(more)
▼ Background: Hepatitis B is a viral infection of the liver and causes both acute and chronic disease. It is transmitted through contact with an infected person’s bodily fluids. It is an occupational hazard for health care workers (HCWs) and can be prevented by the administration of a vaccine. The vaccine is administered in three doses over a six-month period. The Centre for Disease Control recommends that HCWs must be vaccinated against vaccine preventable diseases including hepatitis B. In Zambia, the Ministry of Health acknowledges that this policy exists but is not implemented to its full potential. The objective of the study was to determine the prevalence and determinants of hepatitis B vaccination among HCWs in selected health facilities in Lusaka.
Methods: This was a cross sectional study that consisted of 331 HCWs from seven different health facilities across Lusaka district. The study group consisted of nurses, doctors, laboratory personnel and general workers. Data was collected through a self-administered structured questionnaire. The dependent variable was vaccination status and the independent variables were; age, sex, sharp injuries per year, work experience, knowledge in hepatitis B, profession, training in infection control, skector and facility level. Investigator led stepwise approach was used to select the best predictor variables in a multiple logistic regression model and this was performed using STATA version 12.
Results: Only 19.3% of the HCWs were vaccinated against hepatitis B, with 54.7% being fully vaccinated and 45.3% being partially vaccinated. The analysis showed that; age of the HCW, sharp injuries per year and training in infection control were the variables that were statistically significant in predicting whether a HCW is vaccinated or not vaccinated against hepatitis B. Older HCWs were more likely to be vaccinated against hepatitis B compared to their younger counterparts. HCWs who experienced more sharp injuries in a year were also more likely to be vaccinated against hepatitis B. HCWs who had undergone training in infection control were more likely to be vaccinated against hepatitis B compared to those that had not under gone any training.
Conclusion: There is a low prevalence of hepatitis B vaccination among Zambia’s HCWs. To increase the number of HCWs vaccinated against hepatitis B, health institutions should bear the cost for vaccinating their staff and efforts should also be made to impart appropriate health education regarding hepatitis B infection and its prevention. Establishment of policies on compulsory hepatitis B vaccination of all HCWs in Zambia is recommended.
Subjects/Keywords: Hepatitis B-Lusaka,Zambia;
Hepatitis B-Vaccination-Lusaka,Zambia;
Hepatitis B
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APA (6th Edition):
Mungandi, N. (2017). Hepatitis B Vaccination coverage and the determinants of vaccination in Health Care Workers in seleted Health facilities
. (Thesis). University of Zambia. Retrieved from http://dspace.unza.zm:8080/xmlui/handle/123456789/4868
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mungandi, Namwaka. “Hepatitis B Vaccination coverage and the determinants of vaccination in Health Care Workers in seleted Health facilities
.” 2017. Thesis, University of Zambia. Accessed December 10, 2019.
http://dspace.unza.zm:8080/xmlui/handle/123456789/4868.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mungandi, Namwaka. “Hepatitis B Vaccination coverage and the determinants of vaccination in Health Care Workers in seleted Health facilities
.” 2017. Web. 10 Dec 2019.
Vancouver:
Mungandi N. Hepatitis B Vaccination coverage and the determinants of vaccination in Health Care Workers in seleted Health facilities
. [Internet] [Thesis]. University of Zambia; 2017. [cited 2019 Dec 10].
Available from: http://dspace.unza.zm:8080/xmlui/handle/123456789/4868.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mungandi N. Hepatitis B Vaccination coverage and the determinants of vaccination in Health Care Workers in seleted Health facilities
. [Thesis]. University of Zambia; 2017. Available from: http://dspace.unza.zm:8080/xmlui/handle/123456789/4868
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Zambia
9.
Nchimba, Lweendo.
Prevalence of Hepatitis B and C in Sickle-Cell disease patients at University Teaching Hospital, Lusaka, Zambia
.
Degree: 2015, University of Zambia
URL: http://hdl.handle.net/123456789/3726
► Background: Sickle Cell Disease (SCD) is highly prevalent in Africans. The SCD trait is 18% in the general population in Zambia and University Teaching Hospital…
(more)
▼ Background: Sickle Cell Disease (SCD) is highly prevalent in Africans. The SCD trait is 18% in the general population in Zambia and University Teaching Hospital in Lusaka has under its care over 1500 SCD patients. SCD causes high morbidity and mortality. Patients with SCD often have pathologies that require a blood transfusion. Specific indications for blood transfusion in SCD include acute splenic sequestration, aplastic crises, cardiopulmonary symptoms or signs (e.g. high-output heart failure or hypoxemia), preoperative use, priapism, and life-threatening events that would benefit from improved oxygen delivery such as sepsis, severe infection, acute chest syndrome, stroke, and acute organ ischemia. In addition, blood transfusion remains the first-line therapy for primary and secondary stroke prevention in children with SCD. Transfusion is usually performed when haemoglobin is less than five g/dL.
Both hepatitis B and C are blood-borne and therefore can be transmitted by blood transfusion. SCD patients are a special population that requires frequent blood transfusions. Thus, they are prone to acquiring hepatitis B and C. Screening services have greatly reduced the risk of infection via blood transfusion, but transmissions still occur.
Methods: A cross-sectional study was done to determine the prevalence of hepatitis B (HBV) and / or hepatitis C (HCV) infection in the SCD population at UTH in Lusaka. Basic demographic characteristics, medical information and laboratory data were collected and used to determine the predictors for hepatitis B and HCV infections in SCD children and adults.
A total of 138 patients were screened for Hepatitis B surface antigen, which is a marker for HBV infection, as well as for hepatitis C antibody, the surrogate marker for HCV infection. Human-immuno-deficiency virus or HIV testing was done on all the samples.Findings: Fifty-nine percent of the participants enrolled were female. The mean age at diagnosis was 2years 9 months ± 2.5. The mean haemoglobin level was 7.2g/dL. Only 37% had confirmation of SCD diagnosis on their medical record. HBV prevalence amongst the SCD is 2.2%. Its prevalence is not associated with blood transfusions, age, tattoos or gender. It has a non-significant association with increasing age and sexual activity. HBV infection has been markedly reduced due to vaccination introduced in 2005 in Zambia. The prevalence of HCV is 0.7% and could not be subjected to much statistical manipulation.
Conclusion: HBV prevalence amongst the SCD is 2.2%. Its prevalence was not associated with increase in number of blood transfusions. There was a non-significant association between HBV prevalence and increase in age as well as sexual activity. The prevalence of HCV is 0.7%.
Subjects/Keywords: Sickle-Cell Anemia;
Hepatitis B;
Hepatitis C
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APA (6th Edition):
Nchimba, L. (2015). Prevalence of Hepatitis B and C in Sickle-Cell disease patients at University Teaching Hospital, Lusaka, Zambia
. (Thesis). University of Zambia. Retrieved from http://hdl.handle.net/123456789/3726
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Nchimba, Lweendo. “Prevalence of Hepatitis B and C in Sickle-Cell disease patients at University Teaching Hospital, Lusaka, Zambia
.” 2015. Thesis, University of Zambia. Accessed December 10, 2019.
http://hdl.handle.net/123456789/3726.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Nchimba, Lweendo. “Prevalence of Hepatitis B and C in Sickle-Cell disease patients at University Teaching Hospital, Lusaka, Zambia
.” 2015. Web. 10 Dec 2019.
Vancouver:
Nchimba L. Prevalence of Hepatitis B and C in Sickle-Cell disease patients at University Teaching Hospital, Lusaka, Zambia
. [Internet] [Thesis]. University of Zambia; 2015. [cited 2019 Dec 10].
Available from: http://hdl.handle.net/123456789/3726.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Nchimba L. Prevalence of Hepatitis B and C in Sickle-Cell disease patients at University Teaching Hospital, Lusaka, Zambia
. [Thesis]. University of Zambia; 2015. Available from: http://hdl.handle.net/123456789/3726
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
10.
O'CONNELL, SARAH.
Novel Screening Strategies for HIV, Hepatitis B and C Infection.
Degree: School of Medicine. Discipline of Clinical Medicine, 2018, Trinity College Dublin
URL: http://hdl.handle.net/2262/85303
► Abstract Title: Novel Screening Strategies for HIV, Hepatitis B and C Infection. Author: Dr Sarah O?Connell Introduction: Despite prevention measures in place, rates of HIV…
(more)
▼ Abstract Title: Novel Screening Strategies for HIV,
Hepatitis B and C Infection.
Author: Dr Sarah O?Connell
Introduction: Despite prevention measures in place, rates of HIV infection have failed to decline in Ireland in recent years. From 2015 to 2016, a 6% increase was seen in notifications of newly diagnosed HIV infection. High numbers of chronic
hepatitis B infection continue to be diagnosed in Ireland every year and rates of newly diagnosed
hepatitis C infection have fallen slightly in recent years. The HIV UNAIDS 90-90-90 plan outlines a target for 2020, where 90% of those with HIV infection be diagnosed, 90% of those are linked to care and 90% of those are on effective anti-retroviral therapy. The National
Hepatitis C Treatment Programme aims to see progression towards eradication of
hepatitis C by 2026. Risk based screening nationally are the most common screening practices in Ireland. I proposed to undertake a research programme to understand current HIV presentation patterns and the current landscape of blood borne virus cascade of care, to introduce a pilot blood borne virus screening programme, to examine the feasibility and acceptability of such a programme and to examine the sero-prevalence of infection in a high-prevalence cohort. I aimed to understand the demographics of those diagnosed, measure linkage to care rates, monitor patients through their treatment pathways and examine ways to improve the testing and follow up service.
Methods: Retrospective cohort studies examining HIV,
hepatitis B and C retention in care rates and treatment outcomes were undertaken at our centre. A nested case control study examining factors associated with non-retention in HIV care was performed. A retrospective cohort study of those who presented with late HIV infection at our centre from 2002 and 2014 was then performed. A cross sectional pilot study was then undertaken, where 10,000 patient samples in St James?s Hospital Emergency Department were tested on an opt-out basis for HIV,
hepatitis B and C infection. Uptake rate of testing was recorded. Given high rates of poor engagement to
hepatitis C care, a retrospective cohort study of those with known
hepatitis C infection was then performed to understand factors associated with non-engagement in
hepatitis C care. Success of this pilot study led to the implementation of blood-borne virus testing as routine care. Referrals to the Department of Genito-Urinary Medicine and Infectious Diseases were recorded and tracked to monitor retention in care and triage/treatment outcomes. A quality improvement programme was then undertaken to explore ways to improve
hepatitis C retention in care.
Results: Patients with heterosexual mode of acquisition and of an older age were more likely to present at a late point in their HIV illness, suggesting a non-risk based HIV screening approach is necessary. In our BBV cohort, retention in HIV care rates are comparable with international standards, but can be improved upon to meet the UNAIDS 90-90-90 target.
Hepatitis B and C retention in…
Advisors/Committee Members: Bergin, Colm.
Subjects/Keywords: HIV; Hepatitis B; Hepatitis C; Screening
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APA (6th Edition):
O'CONNELL, S. (2018). Novel Screening Strategies for HIV, Hepatitis B and C Infection. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/85303
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
O'CONNELL, SARAH. “Novel Screening Strategies for HIV, Hepatitis B and C Infection.” 2018. Thesis, Trinity College Dublin. Accessed December 10, 2019.
http://hdl.handle.net/2262/85303.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
O'CONNELL, SARAH. “Novel Screening Strategies for HIV, Hepatitis B and C Infection.” 2018. Web. 10 Dec 2019.
Vancouver:
O'CONNELL S. Novel Screening Strategies for HIV, Hepatitis B and C Infection. [Internet] [Thesis]. Trinity College Dublin; 2018. [cited 2019 Dec 10].
Available from: http://hdl.handle.net/2262/85303.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
O'CONNELL S. Novel Screening Strategies for HIV, Hepatitis B and C Infection. [Thesis]. Trinity College Dublin; 2018. Available from: http://hdl.handle.net/2262/85303
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Addis Ababa University
11.
Yared, Hailaye.
Hepatitis B virus infection among HIV infected individuals with and without antiretroviral therapy in North Shoa Zone, Amhara region, Ethiopia
.
Degree: 2012, Addis Ababa University
URL: http://etd.aau.edu.et/dspace/handle/123456789/2921
► Background- The introduction of highly active antiretroviral treatment (HAART) has greatly decreased morbidity and mortality in HIV-infected individuals. In this regard, HBV co infection with…
(more)
▼ Background- The introduction of highly active antiretroviral treatment (HAART) has greatly
decreased morbidity and mortality in HIV-infected individuals. In this regard, HBV co
infection with HIV is becoming a major challenge. Because of shared routes of transmission,
90% of people living with HIV have serological markers of HBV infection and 5-15% of them
chronically infected with
Hepatitis B Virus. Conditions associated with
hepatitis B infection
are currently among the leading causes of hospital admission and recent studies have shown
increasing rates of liver disease and related death among those with HIV.
The impact of co-infection is especially apparent in regions with widespread use of highly
active antiretroviral therapy (HAART) where HBV co infection increase hepatotoxicity of
HAART and delay immune recovery
Objective- To determine the prevalence of
hepatitis B virus (HBV) infection among
HIV/infected individuals attending care and treatment services in North Shoa zone
Methods – A Cohort study was conducted in North Shoa zone from November 2010 to May
2011.HIV infected individuals who were grouped into antiretroviral treatment initiated and
Pre- treatment follow up were included in the study. Socio-demographic and clinical data were
collected from patient interview, intake form, follow up form and medical record review using
structured questionnaire. HBV sero-status was determined by testing presence of
Hepatitis B
surface antigen using 100ul of serum or plasma detected by SD BIOLINE HBsAg rapid kit
confirmed with AxSYM HBsAg(V2) confirmatory test from blood collected for patients
follow up. Levels of Alanine transaminase and Aspartate transaminase enzymes and CD4+
count were recorded from laboratory registry and patient follow up forms. Usage of HAART
was included to assess if treatment change the natural history of HBV infection. Comparison
groups were HBV positive antiretroviral receiving patients and HBV positive antiretroviral
Naïve ones.
VI
Results- The cumulative prevalence of HBsAg in HIV infected individuals was 3.9%.The
prevalence was higher in ART initiated than Pre-ART groups, 5.3% and 2.6%, respectively.
Despite the difference is not significant. Sex was independently associated with HBsAg
prevalence (P=0.03). Males were in increased risk of developing a positive HBsAg test result.
(RR=2.32 95%CI: 1.09, 4.96) HBV/HIV co infection was a strong predictor of sharp drop in
CD4 cell recovery before starting ART (RR=3.98 95%CI: 1.02,15.48) There was no significant
difference observed in the rate of immune recovery and incidence of hepatotoxicity between
hepatitis B virus Co-infected and non infected individuals after initiation of ART.
Hepatitis B Co-infected individuals isolated were found to be in the chronic
Hepatitis B stage
with low or moderate Alanine and Aspartate transaminases levels. (41.5IU/L)
Conclusion- The prevalence of
hepatitis B infection is higher in ART initiated individuals
than Pre-ART. Neither HBsAg sero positivity nor a particular ART regimen affect immune
recovery in ART…
Advisors/Committee Members: Dr. Solomon Gebre-Selassie (MD, MSc,Associate professor) (advisor).
Subjects/Keywords: Hepatitis B virus infection
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APA (6th Edition):
Yared, H. (2012). Hepatitis B virus infection among HIV infected individuals with and without antiretroviral therapy in North Shoa Zone, Amhara region, Ethiopia
. (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/2921
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Yared, Hailaye. “Hepatitis B virus infection among HIV infected individuals with and without antiretroviral therapy in North Shoa Zone, Amhara region, Ethiopia
.” 2012. Thesis, Addis Ababa University. Accessed December 10, 2019.
http://etd.aau.edu.et/dspace/handle/123456789/2921.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Yared, Hailaye. “Hepatitis B virus infection among HIV infected individuals with and without antiretroviral therapy in North Shoa Zone, Amhara region, Ethiopia
.” 2012. Web. 10 Dec 2019.
Vancouver:
Yared H. Hepatitis B virus infection among HIV infected individuals with and without antiretroviral therapy in North Shoa Zone, Amhara region, Ethiopia
. [Internet] [Thesis]. Addis Ababa University; 2012. [cited 2019 Dec 10].
Available from: http://etd.aau.edu.et/dspace/handle/123456789/2921.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Yared H. Hepatitis B virus infection among HIV infected individuals with and without antiretroviral therapy in North Shoa Zone, Amhara region, Ethiopia
. [Thesis]. Addis Ababa University; 2012. Available from: http://etd.aau.edu.et/dspace/handle/123456789/2921
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Addis Ababa University
12.
DANIEL, MEKONNEN.
PREVALENCE OF HEPATITIS B VIRUS IN PATIENTS WITH DIABETES MELLITUS: A COMPARATIVE CROSS SECTIONAL STUDY AT WOLDIYA GENERAL HOSPITAL ETHIOPIA
.
Degree: 2012, Addis Ababa University
URL: http://etd.aau.edu.et/dspace/handle/123456789/2932
► Background: Hepatitis B Virus (HBV) infection and its sequelae (cirrhosis and liver cancer) are major global health problems. Overall prevalence in Ethiopia varies from 4.7-16.8%…
(more)
▼ Background:
Hepatitis B Virus (HBV) infection and its sequelae (cirrhosis and liver cancer) are major global health problems. Overall prevalence in Ethiopia varies from 4.7-16.8% for HBsAg and 70-76.4% for at least one marker positive. During recent years evidence has accumulated that in patients with diabetes mellitus, phagocytosis by polymorpho nuclear leukocytes is impaired and disturbances in cell-mediated immune responses can be demonstrated. Cell-mediated immunity is involved in the defense against viruses as well as in that against Mycobacterium and Fungi. However, no increased incidence of viral infections like HBV has yet been reported in patients with diabetes.
Objective: To determine the prevalence of HBsAg in patients with diabetes mellitus and to compare those with the non diabetes. It also asses associated factors and liver function tests (LFT); and compare Diabetic and non Diabetic subjects; and HBV positive and negative participants.
Methods: The study was a comparative cross sectional study design conducted at Woldiya General Hospital using 108 consented study populations from each study group during the period November, 2010 through January, 2011. A convenience sampling method was used. A total of 216 samples were tested for HBsAg serostatus using VISITECT HBsAg rapid test kit and LFT tests using Humastat 80 chemistry analyzer. Data entered to SPSS-16 and then analyzed using the same soft ware. Multivariate logistic regression was used to see the association of HBV with clinical history of participants and sociodemographic variables. All tests were two-sided with α-level of 0.05 and 80% power.
Results: prevalence of HBsAg was equal between diabetes and non diabetes, 3.7% indicating that there was no difference between the two groups. No any Sociodemographic and clinical history of participants were associated with HBV infection (p>0.05) except chronic liver disease.
Conclusion: In this study a positive relation was not indicated between HBV and Diabetes and DM in the study area did not predisposed to HBV infection than the rest of the population.
Advisors/Committee Members: Dr Solomon Gebre-Selassie (MD, M.Sc) (advisor).
Subjects/Keywords: hepatitis B virus;
prevalence,association
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APA (6th Edition):
DANIEL, M. (2012). PREVALENCE OF HEPATITIS B VIRUS IN PATIENTS WITH DIABETES MELLITUS: A COMPARATIVE CROSS SECTIONAL STUDY AT WOLDIYA GENERAL HOSPITAL ETHIOPIA
. (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/2932
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
DANIEL, MEKONNEN. “PREVALENCE OF HEPATITIS B VIRUS IN PATIENTS WITH DIABETES MELLITUS: A COMPARATIVE CROSS SECTIONAL STUDY AT WOLDIYA GENERAL HOSPITAL ETHIOPIA
.” 2012. Thesis, Addis Ababa University. Accessed December 10, 2019.
http://etd.aau.edu.et/dspace/handle/123456789/2932.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
DANIEL, MEKONNEN. “PREVALENCE OF HEPATITIS B VIRUS IN PATIENTS WITH DIABETES MELLITUS: A COMPARATIVE CROSS SECTIONAL STUDY AT WOLDIYA GENERAL HOSPITAL ETHIOPIA
.” 2012. Web. 10 Dec 2019.
Vancouver:
DANIEL M. PREVALENCE OF HEPATITIS B VIRUS IN PATIENTS WITH DIABETES MELLITUS: A COMPARATIVE CROSS SECTIONAL STUDY AT WOLDIYA GENERAL HOSPITAL ETHIOPIA
. [Internet] [Thesis]. Addis Ababa University; 2012. [cited 2019 Dec 10].
Available from: http://etd.aau.edu.et/dspace/handle/123456789/2932.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
DANIEL M. PREVALENCE OF HEPATITIS B VIRUS IN PATIENTS WITH DIABETES MELLITUS: A COMPARATIVE CROSS SECTIONAL STUDY AT WOLDIYA GENERAL HOSPITAL ETHIOPIA
. [Thesis]. Addis Ababa University; 2012. Available from: http://etd.aau.edu.et/dspace/handle/123456789/2932
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Hong Kong
13.
Chong, Chun-kong.
Role of Hepatitis B core and X proteins in HBV
transcription and recruitment of histone modifying enzymes to HBV
covalently closed circular DNA.
Degree: M. Phil., 2017, University of Hong Kong
URL: http://hdl.handle.net/10722/249907
► The hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) exists as a minichromosomal conformation and is the transcriptional template of all HBV RNA. During…
(more)
▼ The hepatitis B virus (HBV) covalently closed
circular DNA (cccDNA) exists as a minichromosomal conformation and
is the transcriptional template of all HBV RNA. During HBV
replication, both the hepatitis B core (HBc) and X (HBx) proteins
are recruited to the cccDNA minichromosome. Both proteins play
multiple roles in viral replication. HBc has been demonstrated to
be a component of the cccDNA minichromosome and exert epigenetic
regulation onviral transcription. HBx is also suggested to
associate with cccDNA and play a role in the maintenance of HBV
replication. This thesis aimed to identify specific amino acid
residue(s) of HBc and HBx that are responsible for their
interaction with cccDNA and their roles in transcriptional
regulation.
For the study of HBc, 17 HBc mutants with either
substitution of arginine to alanine residues or replacement of
nearby residue to bulky phenylalanine in the C-terminal region
(amino acid 150-181) were created. While for HBx, 30 mutants with
consecutive amino acid substitutions at the HBx transactivating
domain (amino acid 51-154) expression plasmids were created. These
HBc or HBx expression plasmids, in wild-type or mutant forms, were
transiently co-transfected with HBc-null or HBx-null plasmid-free
HBV DNA into hepatoma cells. The effects of HBc and HBx mutations
on viral replication were assessed by measuring the levels of
nuclear circularized HBV DNA, intracellular encapsidated HBV DNA,
total HBV RNA, and secretory HBsAg. Furthermore, the recruitment
levels of the histone modifying enzymes towards cccDNA
minichromosome were assessed by measurement of association degree
between specific enzymes and cccDNA.
In this plasmid-free HBV DNA
transient transfection system, a complete HBV replication cycle,
starting from cccDNA-initiated transcription to the secretion of
HBV viral antigens, could be demonstrated. Compared with the
wild-type HBc strain, HBc mutants with mutations in arginine
cluster III and IV (amino acid 164-167; 172-175 respectively) had
significantly lower levels of total HBV RNA, encapsidated HBV DNA,
and secretory HBsAg. Similarly, a lower-than-wild-type level of
total HBV RNA, encapsidated HBV DNA, secretory HBsAg was also
detected in the HBx mutants with mutations at amino acid 55-64 and
121-126.Chromatin immunoprecipitation experiments revealed that
both these HBc and HBx mutants had a lower degree of association
with cccDNA when compared with wild-type. Furthermore, the
recruitment of histone acetyltransferases (HATs) to cccDNA in the
HBc arginine clusters III and IV mutants was lower than that of
wild-type. For the HBx mutants, in addition to the reduced
recruitment of HATs, an augmented recruitment of histone
deacetylases (HDACs) was observed in HBx mutants with mutations at
amino acid 55-64 and 121-126.
In conclusion, this study presented
the importance of specific HBc amino acid residues (164-167 and
172-175) and HBx amino acid residues (55-60and 121-126) in
regulating viral transcription via their interaction with cccDNA
and modulation of the recruitment of…
Subjects/Keywords: Viral proteins; Hepatitis B virus
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
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to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Chong, C. (2017). Role of Hepatitis B core and X proteins in HBV
transcription and recruitment of histone modifying enzymes to HBV
covalently closed circular DNA. (Masters Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/249907
Chicago Manual of Style (16th Edition):
Chong, Chun-kong. “Role of Hepatitis B core and X proteins in HBV
transcription and recruitment of histone modifying enzymes to HBV
covalently closed circular DNA.” 2017. Masters Thesis, University of Hong Kong. Accessed December 10, 2019.
http://hdl.handle.net/10722/249907.
MLA Handbook (7th Edition):
Chong, Chun-kong. “Role of Hepatitis B core and X proteins in HBV
transcription and recruitment of histone modifying enzymes to HBV
covalently closed circular DNA.” 2017. Web. 10 Dec 2019.
Vancouver:
Chong C. Role of Hepatitis B core and X proteins in HBV
transcription and recruitment of histone modifying enzymes to HBV
covalently closed circular DNA. [Internet] [Masters thesis]. University of Hong Kong; 2017. [cited 2019 Dec 10].
Available from: http://hdl.handle.net/10722/249907.
Council of Science Editors:
Chong C. Role of Hepatitis B core and X proteins in HBV
transcription and recruitment of histone modifying enzymes to HBV
covalently closed circular DNA. [Masters Thesis]. University of Hong Kong; 2017. Available from: http://hdl.handle.net/10722/249907
University of Debrecen
14.
Kontér, Anita.
A krónikus B vírus Hepatitis epidemiológiája,diagnosztikája és kezelése
.
Degree: DE – Népegészségügyi Kar, University of Debrecen
URL: http://hdl.handle.net/2437/253021
► Diplomamunkámban bemutatom a krónikus Hepatitis B vírusfertőzés diagnosztizálására alkalmas módszereket, gyógyszeres terápiáját, prevenciójának fontosságát illetve a globális epidemiológiai viszonyokat. Továbbá felhívom a figyelmet a védőoltás…
(more)
▼ Diplomamunkámban bemutatom a krónikus
Hepatitis B vírusfertőzés diagnosztizálására alkalmas módszereket, gyógyszeres terápiáját, prevenciójának fontosságát illetve a globális epidemiológiai viszonyokat. Továbbá felhívom a figyelmet a védőoltás fontosságára illetve bemutatom a WHO Globális Hepatitisz programját, amely megoldást jelenthet a HBV fertőzés megakadályozására.
Advisors/Committee Members: Tornai, István (advisor), Debreceni Egyetem::Általános Orvostudományi Kar (advisor).
Subjects/Keywords: Hepatitis B
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Kontér, A. (n.d.). A krónikus B vírus Hepatitis epidemiológiája,diagnosztikája és kezelése
. (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/253021
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kontér, Anita. “A krónikus B vírus Hepatitis epidemiológiája,diagnosztikája és kezelése
.” Thesis, University of Debrecen. Accessed December 10, 2019.
http://hdl.handle.net/2437/253021.
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kontér, Anita. “A krónikus B vírus Hepatitis epidemiológiája,diagnosztikája és kezelése
.” Web. 10 Dec 2019.
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Vancouver:
Kontér A. A krónikus B vírus Hepatitis epidemiológiája,diagnosztikája és kezelése
. [Internet] [Thesis]. University of Debrecen; [cited 2019 Dec 10].
Available from: http://hdl.handle.net/2437/253021.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.
Council of Science Editors:
Kontér A. A krónikus B vírus Hepatitis epidemiológiája,diagnosztikája és kezelése
. [Thesis]. University of Debrecen; Available from: http://hdl.handle.net/2437/253021
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.
University of Hong Kong
15.
Zhang, Anye.
Analysis of hepatitis B virus genetic heterogeneity in
chronic hepatitis B patients with hepatocellular
carcinoma.
Degree: PhD, 2015, University of Hong Kong
URL: Zhang,
A.
[张安业].
(2015).
Analysis
of
hepatitis
B
virus
genetic
heterogeneity
in
chronic
hepatitis
B
patients
with
hepatocellular
carcinoma.
(Thesis).
University
of
Hong
Kong,
Pokfulam,
Hong
Kong
SAR.
Retrieved
from
http://dx.doi.org/10.5353/th_b5610984
;
http://hdl.handle.net/10722/221167
► The involvement of hepatitis B virus (HBV) genetic heterogeneity in liver disease progression to hepatocellular carcinoma (HCC) is not fully understood. We aimed to analyze…
(more)
▼ The involvement of hepatitis B virus (HBV) genetic
heterogeneity in liver disease progression to hepatocellular
carcinoma (HCC) is not fully understood. We aimed to analyze HBV
genetic heterogeneity in chronic hepatitis B (CHB) patients with
HCC.
Full-length HBV genome sequences were characterized in both
tumor and non-tumor tissues from 14 HCC patients by direct
sequencing. HBV DNA sequences from HCC tumor tissues displayed
different mutation patterns from those in non-tumor tissues.
Hotspot mutations at HBx aa130-131 and preS deletions were detected
in 13 (93%) and 6 (43%) patients, respectively. Deletions in the
X/preC/C gene were more frequently detected in the tumor tissues
than non-tumor tissues (p=0.031).
HBV quasispecies
characteristics within the preS region were further investigated in
the HCC tumor and non-tumor tissues using clonal sequencing.
Compared with the nontumor tissues, tumor tissues had a lower
quasispecies complexity and lower diversity at both the nucleotide
and amino acid levels (all p<0.05). Phylogenetic analysis showed
that HBV sequences derived from tumor and non-tumor tissues were
separately clustered, suggesting the occurrence of
compartmentalization, which was confirmed by correlation
coefficient testing (all p<0.02).
The prevalence and
evolutionary changes of HBV preS mutations in up to 10 years prior
to the development of HCC were studied in 74 HCC and 148 age- and
sex-matched HCC-free CHB patients. Higher frequencies of preS
deletions and point-mutations at 11 codon positions were observed
in the HCC patients than in the HCC-free patients (all p<0.05).
Multiple logistic regression analysis showed that preS deletions,
and pointmutations at codons 51 and 167 were independent risk
factors for HCC development. Longitudinal observation showed that
preS deletions and most of the 11 point-mutations existed at least
10 years before HCC development, and were more prevalent in HCC
patients than in HCC-free patients. The number of HCC-associated
preS point-mutations increased over time prior to HCC development,
and correlated positively with the time to HCC diagnosis (r=0.194,
p=0.006).
Deep sequencing analysis of HBV quasispecies
characteristics in preS region prior to HCC was performed in the
sera of 32 HCC and 32 matched HCC-free CHB patients. Compared with
the HCC-free patients, patients who eventually developed HCC had a
higher quasispecies complexity (p=0.001 and 0.002, at the
nucleotide and amino acid levels, respectively) and greater
diversity (p=0.005 and 0.007, at the nucleotide and amino acid
levels, respectively). HCC patients also had a higher intrapatient
prevalence of preS deletions and point-mutations compared to
HCC-free patients (all p<0.05). Longitudinal observation in the
sera of 14 HCC patients and 14 matched HCC-free patients showed
that quasispecies complexity and diversity increased as the disease
progressed to HCC development.
In summary, this study identified
a dynamic change of viral heterogeneity (pointmutations, deletions
and quasispecies…
Subjects/Keywords: Liver - Cancer; Hepatitis B virus
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Zhang, A. (2015). Analysis of hepatitis B virus genetic heterogeneity in
chronic hepatitis B patients with hepatocellular
carcinoma. (Doctoral Dissertation). University of Hong Kong. Retrieved from Zhang, A. [张安业]. (2015). Analysis of hepatitis B virus genetic heterogeneity in chronic hepatitis B patients with hepatocellular carcinoma. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5610984 ; http://hdl.handle.net/10722/221167
Chicago Manual of Style (16th Edition):
Zhang, Anye. “Analysis of hepatitis B virus genetic heterogeneity in
chronic hepatitis B patients with hepatocellular
carcinoma.” 2015. Doctoral Dissertation, University of Hong Kong. Accessed December 10, 2019.
Zhang, A. [张安业]. (2015). Analysis of hepatitis B virus genetic heterogeneity in chronic hepatitis B patients with hepatocellular carcinoma. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5610984 ; http://hdl.handle.net/10722/221167.
MLA Handbook (7th Edition):
Zhang, Anye. “Analysis of hepatitis B virus genetic heterogeneity in
chronic hepatitis B patients with hepatocellular
carcinoma.” 2015. Web. 10 Dec 2019.
Vancouver:
Zhang A. Analysis of hepatitis B virus genetic heterogeneity in
chronic hepatitis B patients with hepatocellular
carcinoma. [Internet] [Doctoral dissertation]. University of Hong Kong; 2015. [cited 2019 Dec 10].
Available from: Zhang, A. [张安业]. (2015). Analysis of hepatitis B virus genetic heterogeneity in chronic hepatitis B patients with hepatocellular carcinoma. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5610984 ; http://hdl.handle.net/10722/221167.
Council of Science Editors:
Zhang A. Analysis of hepatitis B virus genetic heterogeneity in
chronic hepatitis B patients with hepatocellular
carcinoma. [Doctoral Dissertation]. University of Hong Kong; 2015. Available from: Zhang, A. [张安业]. (2015). Analysis of hepatitis B virus genetic heterogeneity in chronic hepatitis B patients with hepatocellular carcinoma. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5610984 ; http://hdl.handle.net/10722/221167
University of Hong Kong
16.
Chung, Tien-jung, Albert.
Hepatitis B and glucose metabolism : a systematic
review.
Degree: MPH, 2014, University of Hong Kong
URL: Chung,
T.
A.
[鍾典融].
(2014).
Hepatitis
B
and
glucose
metabolism
:
a
systematic
review.
(Thesis).
University
of
Hong
Kong,
Pokfulam,
Hong
Kong
SAR.
Retrieved
from
http://dx.doi.org/10.5353/th_b5320246
;
http://dx.doi.org/10.5353/th_b5320246
;
http://hdl.handle.net/10722/206934
► Background/Aim: Hepatitis C virus infection is a known risk factor of impaired glucose metabolism and diabetes mellitus. Whether hepatitis B virus (HBV) infection is also…
(more)
▼ Background/Aim: Hepatitis C virus infection is a
known risk factor of impaired glucose metabolism and diabetes
mellitus. Whether hepatitis B virus (HBV) infection is also
associated with impaired glucose tolerance remains uncertain. The
aim of the study was to conduct a systematic review on the
association between HBV infection and impaired glucose metabolism
Methods: Studies reporting the association between HBV infection
and markers of impaired glucose metabolism were identified through
keyword search in PubMed and Google Scholar. 10 studies (out of
320) were included in this systematic review.
Results were
included. Majority (n=7) of the included studies were conducted
among the Asian populations. Of the 10 included studies, eight
studies reported a significant association between HBV infection
and impaired glucose metabolism, proxied by impaired glucose
tolerance, impaired fasting glucose, diabetes mellitus, insulin
resistance, and metabolic syndromes. The remaining two studies
using diabetes mellitus and insulin resistance as outcome measures
did not find a positive association with HBV infection.
Conclusions: The association between HBV and impaired glucose
metabolism is suggestive from the evidence compiled from included
articles. However, whether the development of glucose intolerance
or diabetes mellitus is linked to an infectious cause of HBV is
still inconclusive. Further studies that could improve on the
current understanding of the associations between HBV infection and
impaired glucose metabolism are necessary.
published_or_final_version
Public Health
Master
Master of Public Health
Subjects/Keywords: Hepatitis B; Glucose - Metabolism
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Chung, Tien-jung, A. (2014). Hepatitis B and glucose metabolism : a systematic
review. (Masters Thesis). University of Hong Kong. Retrieved from Chung, T. A. [鍾典融]. (2014). Hepatitis B and glucose metabolism : a systematic review. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5320246 ; http://dx.doi.org/10.5353/th_b5320246 ; http://hdl.handle.net/10722/206934
Chicago Manual of Style (16th Edition):
Chung, Tien-jung, Albert. “Hepatitis B and glucose metabolism : a systematic
review.” 2014. Masters Thesis, University of Hong Kong. Accessed December 10, 2019.
Chung, T. A. [鍾典融]. (2014). Hepatitis B and glucose metabolism : a systematic review. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5320246 ; http://dx.doi.org/10.5353/th_b5320246 ; http://hdl.handle.net/10722/206934.
MLA Handbook (7th Edition):
Chung, Tien-jung, Albert. “Hepatitis B and glucose metabolism : a systematic
review.” 2014. Web. 10 Dec 2019.
Vancouver:
Chung, Tien-jung A. Hepatitis B and glucose metabolism : a systematic
review. [Internet] [Masters thesis]. University of Hong Kong; 2014. [cited 2019 Dec 10].
Available from: Chung, T. A. [鍾典融]. (2014). Hepatitis B and glucose metabolism : a systematic review. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5320246 ; http://dx.doi.org/10.5353/th_b5320246 ; http://hdl.handle.net/10722/206934.
Council of Science Editors:
Chung, Tien-jung A. Hepatitis B and glucose metabolism : a systematic
review. [Masters Thesis]. University of Hong Kong; 2014. Available from: Chung, T. A. [鍾典融]. (2014). Hepatitis B and glucose metabolism : a systematic review. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5320246 ; http://dx.doi.org/10.5353/th_b5320246 ; http://hdl.handle.net/10722/206934
University of Hong Kong
17.
Lu, Qiuying, Sandy.
Health economic evaluation of universal infant hepatitis
B vaccination programmes in China.
Degree: PhD, 2014, University of Hong Kong
URL: Lu,
Q.
S.
[呂秋瑩].
(2014).
Health
economic
evaluation
of
universal
infant
hepatitis
B
vaccination
programmes
in
China.
(Thesis).
University
of
Hong
Kong,
Pokfulam,
Hong
Kong
SAR.
Retrieved
from
http://dx.doi.org/10.5353/th_b5334854
;
http://dx.doi.org/10.5353/th_b5334854
;
http://hdl.handle.net/10722/207183
► Introduction: China has about 120 million hepatitis B virus (HBV) carriers and a 7.2% hepatitis B surface antigen (HBsAg) prevalence in 2006.This creates a huge…
(more)
▼ Introduction: China has about 120 million hepatitis
B virus (HBV) carriers and a 7.2% hepatitis B surface antigen
(HBsAg) prevalence in 2006.This creates a huge disease burden and
also leads to significant economic losses. Since 2002, a free
universal infant hepatitis B vaccination programme has provideda
3-dose primary vaccination for all infants. Although some economic
evaluations of this programme have been conducted, a comprehensive
cost-effectiveness analysis (CEA) to estimate long-term benefit
using mathematical modeling would aid understanding of population
strategies for hepatitis B control in large populations. Moreover,
the most common mode of infection is perinataltransmission at
birth. However the more effective immunization programme involving
screening women during pregnancy for HBV-carrier status and
providing passive-active vaccination for newborns has not been
implemented in China.
Aims: To identify the most cost-effective
universal infant hepatitis B vaccination strategy for China.
Method: A hospital-based survey was conducted during 2010-2011 in a
general hospital in Shenzhen, China, in order to obtain costing
data to estimate the economic burden of chronic hepatitis B
patients. Annual direct and indirect costs from this study were
used as cost parameters in the CEA models. Mathematical models were
developed to simulate perinatal transmission, vaccination
programmes and disease progression using Markov modeling and
decision trees. Quality-adjusted life year (QALYs) as well as
health and monetary outcomes were also assessed. Univariate
sensitivity analysis and probabilistic sensitivity analysis using
Monte Carlo simulation were performed to test parameter
uncertainty. Two programmes of screening of pregnant women for both
HBsAg and/or HBeAg and the infant passive-active vaccination were
compared with the current vaccine-only programme in one CEA, while
the other CEA estimated the effect of the current infant programme
compared with no vaccination.
Findings: The estimated total
economic burden including annual direct and indirect cost among
hepatitis B patients of RMB 43104.5 (US$6340.8). The economic
burdens of associated disease states of hepatitis B infection were
highest for hepatocellular carcinoma (HCC) (RMB 77297.1),
decompensated cirrhosis (RMB 50725.7), chronic active hepatitis B
(CAH) (RMB 37449.5) and finally compensated cirrhosis (RMB
37276.9). The average total economic burden per hepatitis B patient
amounted to 46% of Shenzhen GDP per capitain 2010, and 5.4% of the
city’s annual per capita income. The current vaccine-only infant
vaccination programme was justified by costsavings, from both a
societal and health care payer’s perspective, reducing new HBV
infections by about 76%. This has produced a gain of 743,000
life-years and 620,000 QALYs given current numbers and savings of
US$2~3billion saved over the lifetime of a national cohortof
10,000,000 newborns. A universal control programme involving the
screening of pregnant women for HBsAg and passive-active
vaccination, would reduce…
Subjects/Keywords: Hepatitis B - Vaccination - China
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Lu, Qiuying, S. (2014). Health economic evaluation of universal infant hepatitis
B vaccination programmes in China. (Doctoral Dissertation). University of Hong Kong. Retrieved from Lu, Q. S. [呂秋瑩]. (2014). Health economic evaluation of universal infant hepatitis B vaccination programmes in China. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5334854 ; http://dx.doi.org/10.5353/th_b5334854 ; http://hdl.handle.net/10722/207183
Chicago Manual of Style (16th Edition):
Lu, Qiuying, Sandy. “Health economic evaluation of universal infant hepatitis
B vaccination programmes in China.” 2014. Doctoral Dissertation, University of Hong Kong. Accessed December 10, 2019.
Lu, Q. S. [呂秋瑩]. (2014). Health economic evaluation of universal infant hepatitis B vaccination programmes in China. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5334854 ; http://dx.doi.org/10.5353/th_b5334854 ; http://hdl.handle.net/10722/207183.
MLA Handbook (7th Edition):
Lu, Qiuying, Sandy. “Health economic evaluation of universal infant hepatitis
B vaccination programmes in China.” 2014. Web. 10 Dec 2019.
Vancouver:
Lu, Qiuying S. Health economic evaluation of universal infant hepatitis
B vaccination programmes in China. [Internet] [Doctoral dissertation]. University of Hong Kong; 2014. [cited 2019 Dec 10].
Available from: Lu, Q. S. [呂秋瑩]. (2014). Health economic evaluation of universal infant hepatitis B vaccination programmes in China. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5334854 ; http://dx.doi.org/10.5353/th_b5334854 ; http://hdl.handle.net/10722/207183.
Council of Science Editors:
Lu, Qiuying S. Health economic evaluation of universal infant hepatitis
B vaccination programmes in China. [Doctoral Dissertation]. University of Hong Kong; 2014. Available from: Lu, Q. S. [呂秋瑩]. (2014). Health economic evaluation of universal infant hepatitis B vaccination programmes in China. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5334854 ; http://dx.doi.org/10.5353/th_b5334854 ; http://hdl.handle.net/10722/207183
Queen Mary, University of London
18.
Dias, Aruna.
Chronic hepatitis B infection in the immigrant communities of East London.
Degree: Thesis (M.D.), 2014, Queen Mary, University of London
URL: http://qmro.qmul.ac.uk/xmlui/handle/123456789/8963
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667311
► Worldwide there are 350 million people with chronic hepatitis B infection and globally it causes up to half of the liver cancer deaths and one…
(more)
▼ Worldwide there are 350 million people with chronic hepatitis B infection and globally it causes up to half of the liver cancer deaths and one third of deaths from cirrhosis. Only a fraction of sufferers will develop these complications. Various studies have implicated socio-demographic, biochemical and viral factors in disease progression but research has been limited to local populations in endemic countries. Our aim was to study the prevalence and factors associated with advanced disease of hepatitis B infection in immigrants living in East London. I completed a retrospective analysis of notes and electronic health records of 1209 immigrant patients attending hospitals in East London, 217 of whom were from Bangladesh and Pakistan. Screening of volunteers attending local mosques using oral mucosal transudate swabs and national statistics data allowed us to calculate prevalence rates in these populations. Those 13 patients from Bangladesh and Pakistan admitted over 30 months with decompensated disease were men aged > 40. Age, sex, ALT, smoking, alcohol and diabetes were significant predictors for cirrhosis and decompensated disease but not viral markers. Similar analyses were performed for other ethnicities with similar outcomes. The scale of under diagnosis of hepatitis B for all ethnicities was estimated and the reasons explored. This work has scrutinised the epidemiology of chronic hepatitis B in East London and the difficulties encountered exploring it. We provide differing results to published studies and suggestions for how this domain can be examined further.
Subjects/Keywords: 616.3; Medicine; Hepatitis B
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APA (6th Edition):
Dias, A. (2014). Chronic hepatitis B infection in the immigrant communities of East London. (Doctoral Dissertation). Queen Mary, University of London. Retrieved from http://qmro.qmul.ac.uk/xmlui/handle/123456789/8963 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667311
Chicago Manual of Style (16th Edition):
Dias, Aruna. “Chronic hepatitis B infection in the immigrant communities of East London.” 2014. Doctoral Dissertation, Queen Mary, University of London. Accessed December 10, 2019.
http://qmro.qmul.ac.uk/xmlui/handle/123456789/8963 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667311.
MLA Handbook (7th Edition):
Dias, Aruna. “Chronic hepatitis B infection in the immigrant communities of East London.” 2014. Web. 10 Dec 2019.
Vancouver:
Dias A. Chronic hepatitis B infection in the immigrant communities of East London. [Internet] [Doctoral dissertation]. Queen Mary, University of London; 2014. [cited 2019 Dec 10].
Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/8963 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667311.
Council of Science Editors:
Dias A. Chronic hepatitis B infection in the immigrant communities of East London. [Doctoral Dissertation]. Queen Mary, University of London; 2014. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/8963 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667311
Stellenbosch University
19.
King, Jeanmari.
A survey to assess the prevalence of Hepatitis B in the adult HIV positive population of the TC Newman ARV centre, Paarl.
Degree: Interdisciplinary Health Sciences, 2015, Stellenbosch University
URL: http://hdl.handle.net/10019.1/97222
► Background: Hepatitis B Virus (HBV) and Human Immunodeficiency Virus (HIV) co-infection in South Africa is estimated between 5-17%; however research determining this prevalence is lacking.…
(more)
▼ Background:
Hepatitis B Virus (HBV) and Human Immunodeficiency Virus (HIV) co-infection in South Africa is estimated between 5-17%; however research determining this prevalence is lacking. With co-infection there is increased risk of liver cirrhosis, end stage liver disease, death as well as higher rates of chronic
Hepatitis B infection. Chronic HBV develops in 20% of HIV positive individuals when compared to less than 5% in HIV negative individuals. This also further complicates Highly Active AntiRetroviral Treatment (HAART).
Methods: A retrospective observational quantitative, cross-sectional, analytical study was done at the TC Newman Antiretroviral (ARV) centre in Paarl. All adult HIV positive patients that were started on antiretroviral therapy for the time period the new protocol was implemented were analyzed according to their
Hepatitis B Antigen (HBsAg) result as well as for any association with gender, CD4 and age. The new protocol stated that all patients who were to start ARV’s had to be tested for
Hepatitis B by testing their HBsAg.
Results: A total of 498 participants were identified of which 40% were male and 60% were female. The HBsAg positivity rate was established at 7.6%. A higher prevalence was found among men as well as in the age group 50-59 years and those with a CD4 of 50/μL and less.
Conclusions: With a prevalence of almost 8% there should definitely be a recommendation towards routine testing of HIV positive patients for
Hepatitis B. If not before commencing ART then at least when switching from a regimen containing Lamivudine (3TC) or Tenofovir (TDF) to a regimen not containing these drugs in order to prevent acute flare ups of
hepatitis.
Advisors/Committee Members: Hagemeister, Dirk, University of Stellenbosch. Faculty of Health Sciences. Dept. of Interdisciplinary Health Sciences.
Subjects/Keywords: Hepatitis B; adult HIV positive
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APA (6th Edition):
King, J. (2015). A survey to assess the prevalence of Hepatitis B in the adult HIV positive population of the TC Newman ARV centre, Paarl. (Thesis). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/97222
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
King, Jeanmari. “A survey to assess the prevalence of Hepatitis B in the adult HIV positive population of the TC Newman ARV centre, Paarl.” 2015. Thesis, Stellenbosch University. Accessed December 10, 2019.
http://hdl.handle.net/10019.1/97222.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
King, Jeanmari. “A survey to assess the prevalence of Hepatitis B in the adult HIV positive population of the TC Newman ARV centre, Paarl.” 2015. Web. 10 Dec 2019.
Vancouver:
King J. A survey to assess the prevalence of Hepatitis B in the adult HIV positive population of the TC Newman ARV centre, Paarl. [Internet] [Thesis]. Stellenbosch University; 2015. [cited 2019 Dec 10].
Available from: http://hdl.handle.net/10019.1/97222.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
King J. A survey to assess the prevalence of Hepatitis B in the adult HIV positive population of the TC Newman ARV centre, Paarl. [Thesis]. Stellenbosch University; 2015. Available from: http://hdl.handle.net/10019.1/97222
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Johannesburg
20.
Caldwell, Sarah.
The production of the antibody to the surface antigen of Hepatitis B (anti-HBs) due to Hepatitis B 12cH nosode administration.
Degree: 2014, University of Johannesburg
URL: http://hdl.handle.net/10210/10202
► M.Tech. (Homoeopathy)
According to the World Health Organisation (2008), an estimated two billion individuals globally, are infected with Hepatitis B (HBV). South Africa reported 864…
(more)
▼ M.Tech. (Homoeopathy)
According to the World Health Organisation (2008), an estimated two billion individuals globally, are infected with Hepatitis B (HBV). South Africa reported 864 notified new cases between 2001 and 2004 (Department Of Health, 2005), with an estimated 3-4 million chronic HBV infected black South Africans (Kew, 2008). Kwa-Zulu Natal and Free State were the most affected provinces; while 20-39 years was the most affected age group as of 2005 (Department Of Health, 2005). Workers in the health industry, intravenous drug users and children of women who have Hepatitis B are at the most risk for contracting this disease from blood products and body fluids (Immunization Action Coalition, 2007; Boon et al., 2006), where contraction of the disease can lead to liver cirrhosis, fibrosis and hepato-cellular carcinoma (Highleyman, 2008). The Expanded Program on Immunization (EPI) of the South African Department of Health (2009) suggests vaccination for Hepatitis B should be administered at six, ten and fourteen weeks, or a dose every month for 3 months. Adverse reactions associated with the vaccine include “Guillain-Barre Syndrome, arthritis, demyelinating nervous system disease” (Pratt, 2008) and anaphylaxis (Danis & Halm, 1997). Alternatives that may assist in avoiding such symptoms include: waiting until adolescence to vaccinate (Slonim et al., 2005); only vaccinating high risk groups (Francois et al., 2002); or researching an alternative (Romm, 2001). Homeoprophylaxis is the use of homeopathy to prevent the contraction or development of disease (Zoltan, 2000) and its successful use has been recorded in various disease types and locations. There have been very few studies to show the effect of individual homeopathic nosodes used as prophylactic treatment in their related diseases, with almost none of these utilising any means of serological testing (Bevan-Jones, 2009; Frost et al., 2003; Sheffield, 2006). The aim of this study was to determine the production of the antibody to the surface antigen of Hepatitis B (anti-Hbs) due to Hepatitis B 12cH nosode administration. Forty-three participants ranging, in ages 18 to 65 years, who tested negative for the presence of anti-HBs, took part in this four week long, double-blind, placebo controlled study. Participants were randomly placed into either the Verum or Placebo group, each group receiving four lactose powders to be taken weekly for four weeks. The Active group received lactose powders medicated with Hepatitis B 12cH, whereas the Placebo group received lactose powders medicated with 96% alcohol. Participants underwent a repeat of the serum/plasma antibody testing at the conclusion of the study to determine if there were anti-HBs present in their blood. The results were then statistically analysed using nonparametric testing: Chi-squared independent test, Mann-Whitney test and Sign test. These showed that there was no change measurable effect on the surface antigen of hepatitis B (anti-HBs) of either the Verum (active medication) or Placebo group.…
Subjects/Keywords: Hepatitis B - Prevention; Immunoglobulins; Homeopathy
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APA (6th Edition):
Caldwell, S. (2014). The production of the antibody to the surface antigen of Hepatitis B (anti-HBs) due to Hepatitis B 12cH nosode administration. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/10202
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Caldwell, Sarah. “The production of the antibody to the surface antigen of Hepatitis B (anti-HBs) due to Hepatitis B 12cH nosode administration.” 2014. Thesis, University of Johannesburg. Accessed December 10, 2019.
http://hdl.handle.net/10210/10202.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Caldwell, Sarah. “The production of the antibody to the surface antigen of Hepatitis B (anti-HBs) due to Hepatitis B 12cH nosode administration.” 2014. Web. 10 Dec 2019.
Vancouver:
Caldwell S. The production of the antibody to the surface antigen of Hepatitis B (anti-HBs) due to Hepatitis B 12cH nosode administration. [Internet] [Thesis]. University of Johannesburg; 2014. [cited 2019 Dec 10].
Available from: http://hdl.handle.net/10210/10202.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Caldwell S. The production of the antibody to the surface antigen of Hepatitis B (anti-HBs) due to Hepatitis B 12cH nosode administration. [Thesis]. University of Johannesburg; 2014. Available from: http://hdl.handle.net/10210/10202
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
21.
Stanković, Ana.
SPREMLJANJE GIBANJA HEPATITISA B V SLOVENIJI V DESETLETNEM OBDOBJU.
Degree: 2015, Univerza v Mariboru
URL: https://dk.um.si/IzpisGradiva.php?id=46751
;
https://dk.um.si/Dokument.php?id=69543&dn=
;
https://plus.si.cobiss.net/opac7/bib/2064804?lang=sl
► V magistrskem delu smo predstavili virus hepatitisa B, opisali njegove poti prenosa, simptome, diagnostiko ter zdravljenje. Opisali smo cepljenje proti hepatitisu B ter vlogo medicinske…
(more)
▼ V magistrskem delu smo predstavili virus hepatitisa B, opisali njegove poti prenosa, simptome, diagnostiko ter zdravljenje. Opisali smo cepljenje proti hepatitisu B ter vlogo medicinske sestre pri preprečevanju okužbe. Namen magistrskega dela je bil analizirati novejše statistične podatke o spremljanju gibanja hepatitisa B v Sloveniji in po svetu. S pomočjo podatkov Nacionalnega inštituta za javno zdravje Republike Slovenije smo dobljene podatke analizirali in jih primerjali z državami Evropske unije.
Raziskovalna metodologija. Magistrsko delo temelji na deskriptivni epidemiološki metodi. Statistično je bila izvedena demografska (prijava bolezni po starostnih skupinah), kronološka (skupen prikaz incidence in mortalitete po letih) in topografska analiza (prijava bolezni po zdravstvenih regijah) primerov hepatitisa B v Sloveniji.
Rezultati. V Sloveniji je pogostost hepatitisa B v primerjavi z Evropo nizka, pri čemer je incidenca kroničnega hepatitisa B na 100.000 prebivalcev višja od akutnega hepatitisa B. V Sloveniji bistveno bolj obolevajo moški kot ženske. Akutni hepatitis B se najpogosteje pojavlja v starosti od 25 do 44 let, kronični hepatitis B pa od rojstva do starosti 24 let. Za akutnim hepatitisom B jih je v obdobju desetih let največ zbolelo v mariborski regiji, za kroničnim pa v ljubljanski regiji.
Sklep. V Sloveniji je v skladu z Zakonom o nalezljivih boleznih prijava hepatitisa B obvezna, na ta način se tudi ocenjuje razširjenost bolezni. Prav gotovo je število okužb višje, saj nekateri ljudje ne iščejo zdravstvene pomoči ali prijava ni popolna, okužba pa lahko poteka brez zunanjih znakov.
In this master's thesis we presented the virus hepatitis B, described its ways of transmission, its symptoms, diagnosis and treatment. We described the vaccination against hepatitis B and the nurse's role in preventing infections. The purpose of this master's thesis was to analyze resent statistic data about tracing the movement of hepatitis B in Slovenia and around the world. With the data from the National Institute of Public Health of the Republic of Slovenia we could analyze gathered data and compare it to other European countries.
Research methodology. The master's thesis is based on the descriptive epidemiologic method. Demographic (registration of the disease in certain age groups), chronological (combined presentation of incidence and mortality by certain ages) and topographic analysis (registration of the disease in our health regions) of hepatitis B cases in Slovenia were statistically carried out.
Results. In comparison to other European countries the frequency and occurrence of hepatitis B in Slovenia is low, however the incidence of chronical hepatitis B on 100.000 people is higher than the incidence of acute hepatitis. In Slovenia men get infected more often than women. Acute hepatitis B most frequently affects people between 25 and 44 years of age, but chronical hepatitis B affects people birth to the age of 24. In the period of 10 years most infections with acute hepatitis B were reported in the…
Advisors/Committee Members: Fijan, Sabina.
Subjects/Keywords: hepatitis B; akutni hepatitis B; kronični hepatitis B; nalezljiva bolezen; cepljenje.; hepatitis B; acute hepatitis; chronic hepatitis; contagious disease; vaccination.; info:eu-repo/classification/udc/616.36-002
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APA ·
Chicago ·
MLA ·
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Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Stanković, A. (2015). SPREMLJANJE GIBANJA HEPATITISA B V SLOVENIJI V DESETLETNEM OBDOBJU. (Masters Thesis). Univerza v Mariboru. Retrieved from https://dk.um.si/IzpisGradiva.php?id=46751 ; https://dk.um.si/Dokument.php?id=69543&dn= ; https://plus.si.cobiss.net/opac7/bib/2064804?lang=sl
Chicago Manual of Style (16th Edition):
Stanković, Ana. “SPREMLJANJE GIBANJA HEPATITISA B V SLOVENIJI V DESETLETNEM OBDOBJU.” 2015. Masters Thesis, Univerza v Mariboru. Accessed December 10, 2019.
https://dk.um.si/IzpisGradiva.php?id=46751 ; https://dk.um.si/Dokument.php?id=69543&dn= ; https://plus.si.cobiss.net/opac7/bib/2064804?lang=sl.
MLA Handbook (7th Edition):
Stanković, Ana. “SPREMLJANJE GIBANJA HEPATITISA B V SLOVENIJI V DESETLETNEM OBDOBJU.” 2015. Web. 10 Dec 2019.
Vancouver:
Stanković A. SPREMLJANJE GIBANJA HEPATITISA B V SLOVENIJI V DESETLETNEM OBDOBJU. [Internet] [Masters thesis]. Univerza v Mariboru; 2015. [cited 2019 Dec 10].
Available from: https://dk.um.si/IzpisGradiva.php?id=46751 ; https://dk.um.si/Dokument.php?id=69543&dn= ; https://plus.si.cobiss.net/opac7/bib/2064804?lang=sl.
Council of Science Editors:
Stanković A. SPREMLJANJE GIBANJA HEPATITISA B V SLOVENIJI V DESETLETNEM OBDOBJU. [Masters Thesis]. Univerza v Mariboru; 2015. Available from: https://dk.um.si/IzpisGradiva.php?id=46751 ; https://dk.um.si/Dokument.php?id=69543&dn= ; https://plus.si.cobiss.net/opac7/bib/2064804?lang=sl
University of Alberta
22.
Zimmerman, Kimberley Anne.
Designed zinc finger proteins as novel therapeutics
inhibiting the transcription of hepatitis B and duck hepatitis B
viruses.
Degree: PhD, Department of Medical Microbiology and
Immunology, 2010, University of Alberta
URL: https://era.library.ualberta.ca/files/cr56n098w
► The Hepatitis B virus (HBV) chronically infects 350 million individuals worldwide, leading to mortality by end-stage liver disease, liver cirrhosis, and hepatocellular carcinoma. The vaccine…
(more)
▼ The Hepatitis B virus (HBV) chronically infects 350
million individuals worldwide, leading to mortality by end-stage
liver disease, liver cirrhosis, and hepatocellular carcinoma. The
vaccine to prevent HBV infection is highly effective but is not
extensively available in endemic areas, resulting in high infection
rates. Nucleoside analogue treatment of HBV has allowed for higher
rates of viral clearance in infected individuals, but most patients
must remain on therapy long term and viral resistance to the drugs
is growing. The HBV viral genome is an episome in the nucleus of
infected hepatocytes. It is called covalently closed circular (ccc)
DNA and is highly stable, has a long half-life, and is the template
for all viral transcription and progeny production. Nucleoside
analogues do not directly target cccDNA, therefore many patients
experience rebound when antiviral therapy is stopped. I have
designed novel DNA binding proteins called zinc finger proteins
(ZFPs) to specifically bind to the cccDNA in infected cells and
inhibit viral transcription. Seven ZFPs targeting the model duck
HBV (DHBV) and ten ZFPs targeting HBV were developed. Kinetic
analyses of the purified ZFPs were performed, characterizing their
specificity and binding properties. Using the DHBV tissue culture
model system, I have demonstrated that the DHBV-specific ZFPs can
specifically inhibit transcription from the viral template,
resulting in reduced viral RNA, protein products and progeny
virions. The DHBV-specific ZFPs were tested in primary duck
hepatocytes (PDH) and in vivo in the Pekin duck model. ZFPs failed
to express in PDH transduced by baculovirus vectors when DHBV was
present in the cells. In vivo gene delivery of the ZFPs was carried
out by portal vein injection of chitosan-based nanospheres.
Unfortunately, non-specific reductions in viral levels masked any
direct effect by the ZFPs. Testing of the HBV-specific ZFPs in
tissue culture was hindered by a lack of transfectable cell culture
model. A number of different transfection methods were tested to
express the HBV-specific ZFPs, all without success. Further work is
being carried out using baculovirus vectors to deliver the
HBV-specific ZFPs to HBV-harbouring cell lines and HBV-infected
scid-Alb/uPA chimeric mice with human liver cells.
Subjects/Keywords: zinc finger protein; duck hepatitis B; inhibition; cccDNA; hepatitis B
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Zimmerman, K. A. (2010). Designed zinc finger proteins as novel therapeutics
inhibiting the transcription of hepatitis B and duck hepatitis B
viruses. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/cr56n098w
Chicago Manual of Style (16th Edition):
Zimmerman, Kimberley Anne. “Designed zinc finger proteins as novel therapeutics
inhibiting the transcription of hepatitis B and duck hepatitis B
viruses.” 2010. Doctoral Dissertation, University of Alberta. Accessed December 10, 2019.
https://era.library.ualberta.ca/files/cr56n098w.
MLA Handbook (7th Edition):
Zimmerman, Kimberley Anne. “Designed zinc finger proteins as novel therapeutics
inhibiting the transcription of hepatitis B and duck hepatitis B
viruses.” 2010. Web. 10 Dec 2019.
Vancouver:
Zimmerman KA. Designed zinc finger proteins as novel therapeutics
inhibiting the transcription of hepatitis B and duck hepatitis B
viruses. [Internet] [Doctoral dissertation]. University of Alberta; 2010. [cited 2019 Dec 10].
Available from: https://era.library.ualberta.ca/files/cr56n098w.
Council of Science Editors:
Zimmerman KA. Designed zinc finger proteins as novel therapeutics
inhibiting the transcription of hepatitis B and duck hepatitis B
viruses. [Doctoral Dissertation]. University of Alberta; 2010. Available from: https://era.library.ualberta.ca/files/cr56n098w
University of Zambia
23.
Nsokolo, Bright.
The correlation between baseline serum hepatitis B surface antigen level and levels of other baseline markers of viral activity in patients with chronic hepatitis B viral infection at the University Teaching Hospital
.
Degree: 2015, University of Zambia
URL: http://dspace.unza.zm:8080/xmlui/handle/123456789/4313
► Title: The correlation between baseline serum hepatitis B surface antigen level and levels of other baseline markers of viral activity in chronic hepatitis B viral…
(more)
▼ Title: The correlation between baseline serum hepatitis B surface antigen level and levels of other baseline markers of viral activity in chronic hepatitis B viral infection at the University Teaching Hospital.
Background: Hepatitis B viral (HBV) infection rate among healthy blood donors in Zambia is about 8%, with about 100 000 patients requiring treatment. Effective monitoring of these patients requires the use of the technically difficult and expensive serum HBV DNA levels. Quantifying serum Hepatitis B surface antigen (HBsAg) which is produced by the covalently closed circular DNA (cccDNA), may be a more reliable, simple, inexpensive and non-invasive way of monitoring patients with chronic hepatitis b (CHB) infection. There is a correlation between reduction in serum HBsAg and in cccDNA and total intrahepatic HBV DNA among patients on treatment. However, it remains inconclusive whether serum HBsAg correlates with serum HBV DNA, which would make it helpful in predicting serum viral load.
Objective: To determine whether baseline serum HBsAg quantification correlates with other baseline serum hepatitis B viral markers
Methodology: This was a cross sectional study. Patients with hepatitis B infection were recruited under the STEP-HEP Study from blood donors in Lusaka, Zambia, medical wards and out-patient medical clinics at UTH over a 15 month period. We screened 49 Patients (HBeAg positive: n=14, HBeAg negative: n=35) with chronic HBV (HBsAg positive for at least 24 weeks) for other causes of liver disease and those with alternative causes of hepatitis were excluded. Blood testing was performed for baseline ALT, serum viral load, HBeAg status and serum HBsAg level. Patients with HBV DNA >2000IU/ml and ALT above the upper limit of normal (35U/L) who did not have radiological evidence of cirrhosis were included in the study. Serum HBV DNA and HBsAg were logarithmically transformed for analysis. Categorical variables were compared by the Pearson chi-square test or the Fisher exact test as appropriate. The Pearson and Spearman correlation coefficients were tested for parametric and non-parametric variables respectively. Statistical significance was defined as a P value of less than 0.05
Results: There was a significant inverse correlation between baseline HBsAg and serum HBV DNA (r = -0.38, P= 0.02). The correlation between serum HBsAg and ALT was not significant (p= 0.94). There was no significant difference in HBsAg level between HBeAg positive and HBeAg negative patients (p= 0.06). The correlation between serum viral load and ALT was also not significant (p=0.26). There was significantly higher ALT in HBeAg positive than in HBeAg negative patients (p=0.016). The serum viral load was significantly higher in HBeAg positive than in HBeAg negative patients (p=0.0001)
Conclusion: The inverse correlation between baseline serum HBsAg level and serum HBV DNA may reflect the inadequacy of serum HBV DNA to represent the level of intrahepatic HBV DNA which correlates with serum HBsAg. However, there was no significant…
Subjects/Keywords: Hepatitis B Virus – Research;
Hepatitis B virus – Physiopathology
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Nsokolo, B. (2015). The correlation between baseline serum hepatitis B surface antigen level and levels of other baseline markers of viral activity in patients with chronic hepatitis B viral infection at the University Teaching Hospital
. (Thesis). University of Zambia. Retrieved from http://dspace.unza.zm:8080/xmlui/handle/123456789/4313
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Nsokolo, Bright. “The correlation between baseline serum hepatitis B surface antigen level and levels of other baseline markers of viral activity in patients with chronic hepatitis B viral infection at the University Teaching Hospital
.” 2015. Thesis, University of Zambia. Accessed December 10, 2019.
http://dspace.unza.zm:8080/xmlui/handle/123456789/4313.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Nsokolo, Bright. “The correlation between baseline serum hepatitis B surface antigen level and levels of other baseline markers of viral activity in patients with chronic hepatitis B viral infection at the University Teaching Hospital
.” 2015. Web. 10 Dec 2019.
Vancouver:
Nsokolo B. The correlation between baseline serum hepatitis B surface antigen level and levels of other baseline markers of viral activity in patients with chronic hepatitis B viral infection at the University Teaching Hospital
. [Internet] [Thesis]. University of Zambia; 2015. [cited 2019 Dec 10].
Available from: http://dspace.unza.zm:8080/xmlui/handle/123456789/4313.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Nsokolo B. The correlation between baseline serum hepatitis B surface antigen level and levels of other baseline markers of viral activity in patients with chronic hepatitis B viral infection at the University Teaching Hospital
. [Thesis]. University of Zambia; 2015. Available from: http://dspace.unza.zm:8080/xmlui/handle/123456789/4313
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Adelaide
24.
Noordeen, Faseeha.
Development of antiviral therapies for chronic hepatitis B virus infection.
Degree: 2010, University of Adelaide
URL: http://hdl.handle.net/2440/62330
► Acute hepatitis B virus (HBV) infection is self-limiting but leaves a residual infection that can become active in an individual under conditions of immunosuppression. In…
(more)
▼ Acute
hepatitis B virus (HBV) infection is self-limiting but leaves a residual infection that can become active in an individual under conditions of immunosuppression. In chronic HBV infection, the virus persistently replicates in hepatocytes and this leads to immune mediated hepatocyte damage. Chronic HBV infection, which occurs worldwide in more than 400 million people, is associated with liver disease, fibrosis, cirrhosis and hepatocellular carcinoma (HCC) (
Hepatitis B Fact Sheet 2009). There is a significant need for treatment intervention in chronic HBV infection.
Despite the inability to remove the virus in more than 70% of patients, current treatments for chronic HBV infection, which include interferon alpha (IFN-α) and antiviral nucleotide/nucleoside analogues (NAs), aim to reduce levels of viral replication and to prevent or at least delay the progression of disease and the development of cirrhosis and HCC. Current NA therapy involves monotherapy with a conventional NA as a single antiviral agent (Sasadeusz et al. 2007). In the recent past, poor response to monotherapies with NAs and adverse effects to IFN-α have stimulated research into novel therapeutic strategies and enhancing the efficacy of exsisting NA therapy.
The duck HBV (DHBV) in its natural host, the Pekin duck (Anas domesticus platyrhynchos), has been used as an animal model to study treatment outcomes and antiviral studies at the pre-clinical level. Much of what is known about viral replication and outcomes of hepadnavirus infection has been discovered using the DHBV model (Schultz et al. 2004; Zoulim et al. 2008) and several immunotherapeutic and antiviral studies have been performed recently in our laboratory (Foster et al. 2003; Miller et al. 2004; Foster et al. 2005; Miller et al. 2006a; Miller et al. 2006b; Miller et al. 2008).
The studies described in this Ph.D. thesis focused on the development and testing of novel therapies for chronic HBV infection using the DHBV model. The first approach involved the use of novel amphipathic DNA polymers (APDPs) developed by REPLICor Inc. The second approach tested a combination of NAs developed by Gilead Sciences Pty. Ltd.
APDPs developed by REPLICor Inc. have been used as a novel therapeutic approach against human immunodeficiency virus type 1 (HIV-1) and have been shown to inhibit HIV-1-mediated membrane fusion and HIV-1 replication in a size dependent but sequence independent manner (Vaillant et al. 2006). HIV-1 entry is well characterised and involves fusion of the virus to its target cells using a type 1 fusion protein. APDPs are thought to inhibit HIV-1 infection by acting as fusion inhibitors that bind to the V3 loop of the HIV-1 gp41 domain preventing its interaction with the T cell receptor, CD4.
Phosphorothioation of oligonucleotides increases their hydrophobicity (amphipathicity) and also makes them more resistant to degradation by nucleases. The amphipathicity of APDPs plays a major role in their antiviral activity. Longer APDPs with lengths of ≥30 bases have a greater amphipathicity…
Advisors/Committee Members: Jilbert, Allison Rae (advisor), Beard, Michael Robert (advisor), School of Molecular and Biomedical Science (school).
Subjects/Keywords: antiviral therapies; hepatitis B; virus; chronic hepatitis B
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APA (6th Edition):
Noordeen, F. (2010). Development of antiviral therapies for chronic hepatitis B virus infection. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/62330
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Noordeen, Faseeha. “Development of antiviral therapies for chronic hepatitis B virus infection.” 2010. Thesis, University of Adelaide. Accessed December 10, 2019.
http://hdl.handle.net/2440/62330.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Noordeen, Faseeha. “Development of antiviral therapies for chronic hepatitis B virus infection.” 2010. Web. 10 Dec 2019.
Vancouver:
Noordeen F. Development of antiviral therapies for chronic hepatitis B virus infection. [Internet] [Thesis]. University of Adelaide; 2010. [cited 2019 Dec 10].
Available from: http://hdl.handle.net/2440/62330.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Noordeen F. Development of antiviral therapies for chronic hepatitis B virus infection. [Thesis]. University of Adelaide; 2010. Available from: http://hdl.handle.net/2440/62330
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
25.
Dakić Zoran.
Značaj primene definicije slučaja za unapređenje epidemiološkog nadzora nad hepatitisima B i C.
Degree: 2017, University of Novi Sad
URL: http://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija145923723116719.pdf?controlNumber=(BISIS)100362&fileName=145923723116719.pdf&id=5188&source=OATD&language=en
;
http://www.cris.uns.ac.rs/record.jsf?recordId=100362&source=OATD&language=en
► Adekvatni nadzor nad zaraznim bolestima predstavlja aktuelni izazov ne samo kod nas već i u razvijenim zemljama. Savremeni epidemiološki nadzor nad zaraznim bolestima zasniva…
(more)
▼ Adekvatni nadzor nad zaraznim bolestima predstavlja aktuelni izazov ne samo kod nas već i u razvijenim zemljama. Savremeni epidemiološki nadzor nad zaraznim bolestima zasniva se na odgovarajućim definicijama slučaja. Njihova osnovna funkcija je olakšavanje prepoznavanja određenih bolesti i njihovo registrovanje na jednoobrazan način. Definisanje slučajeva zaraznih bolesti nije jednostavno, jer uključuje kliničke, epidemiološke i laboratorijske parametre, uz istovremeno očekivanje visoke senzitivnosti i specifičnosti. Ciljevi istraživanja su bili da se utvrdi primenljivost definicija slučaja hepatitisa B i C na Klinici za infektivne bolesti Kliničkog centra Vojvodine, te da se utvrdi senzitivnost i specifičnost primenjenih definicija slučaja hepatitisa B i C. Uz postojeći dijagnostički algoritam Klinike za infektivne bolesti Kliničkog centra Vojvodine, uvedena su tri seta definicija hepatitisa B i C: Evropskog centra za prevenciju i kontrolu bolesti (ECDC) iz 2008. i 2012.godine kao i američkih Centara za kontrolu bolesti (CDC) iz 2012. godine. Istraživanje je sprovedeno na Klinici za infektivne bolesti Kliničkog centra Vojvodine i tokom 12 meseci, u skladu sa predloženim definicijama slučaja, identifikovano je 150 ispitanika obolelih od hepatitisa B i C. Utvrđene su sledeće činjenice: preporučene definicije slučaja su primenljive u Republici Srbiji za laboratorijske i kliničke kriterijume, dok uključivanje epidemiološke povezanosti u definicije slučaja ima malo praktičnog značaja za prijavljivanje hepatitisa; definicije slučaja koje uključuju i obavezno prisustvo kliničkih kriterijuma (najčešće definicije verovatnog slučaja) imaju nisku senzitivnost, a visoku specifičnost, kao posledica prisustva infekcije i u odsustvu bilo kakvih kliničkih manifestacija; definicije slučaja koje se zasnivaju samo na laboratorijskim kriterijumima imaju maksimalnu senzitivnost i specifičnost.
Adequate surveillance of communicable diseases is the actual challenge, not only in our country but also in developed countries. Modern epidemiological surveillance of communicable diseases is based on the appropriate case definitions. Their main purpose of them is to facilitate the recognition of certain diseases and their registration in a uniform manner. Case definition of communicable diseases is not easy, because it involves clinical, epidemiological and laboratory parameters, along with the expectated high sensitivity and specificity.The objectives of the study were to determine the applicability of the casedefinitions for hepatitis B and C in the Clinic for Infectious Diseases of the Clinical Center of Vojvodina and to determine the sensitivity and specificity of the applied definition of cases of hepatitis B and C. In addition to existing diagnostic algorithm of the Clinic for Infectious Diseases, three sets of hepatitis B and C case definitions were introduced: the European Centre for Disease Prevention and Control in 2008 and 2012 as well as the US Centers for Disease Control in 2012. The…
Advisors/Committee Members: Đurić Predrag, Fabri Milotka, Dragovac Gorana, Kocić Biljana, Turkulov Vesna, Dugandžija Tihomir, Petrović Vladimir.
Subjects/Keywords: hepatitis B; hepatitis C; dijagnoza; epidemiologija; javno zdravlje; Hepatitis B; Hepatitis C; Diagnosis; Epidemiology; Public Health
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APA ·
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CSE |
Export
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APA (6th Edition):
Zoran, D. (2017). Značaj primene definicije slučaja za unapređenje epidemiološkog nadzora nad hepatitisima B i C. (Thesis). University of Novi Sad. Retrieved from http://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija145923723116719.pdf?controlNumber=(BISIS)100362&fileName=145923723116719.pdf&id=5188&source=OATD&language=en ; http://www.cris.uns.ac.rs/record.jsf?recordId=100362&source=OATD&language=en
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Zoran, Dakić. “Značaj primene definicije slučaja za unapređenje epidemiološkog nadzora nad hepatitisima B i C.” 2017. Thesis, University of Novi Sad. Accessed December 10, 2019.
http://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija145923723116719.pdf?controlNumber=(BISIS)100362&fileName=145923723116719.pdf&id=5188&source=OATD&language=en ; http://www.cris.uns.ac.rs/record.jsf?recordId=100362&source=OATD&language=en.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Zoran, Dakić. “Značaj primene definicije slučaja za unapređenje epidemiološkog nadzora nad hepatitisima B i C.” 2017. Web. 10 Dec 2019.
Vancouver:
Zoran D. Značaj primene definicije slučaja za unapređenje epidemiološkog nadzora nad hepatitisima B i C. [Internet] [Thesis]. University of Novi Sad; 2017. [cited 2019 Dec 10].
Available from: http://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija145923723116719.pdf?controlNumber=(BISIS)100362&fileName=145923723116719.pdf&id=5188&source=OATD&language=en ; http://www.cris.uns.ac.rs/record.jsf?recordId=100362&source=OATD&language=en.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Zoran D. Značaj primene definicije slučaja za unapređenje epidemiološkog nadzora nad hepatitisima B i C. [Thesis]. University of Novi Sad; 2017. Available from: http://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija145923723116719.pdf?controlNumber=(BISIS)100362&fileName=145923723116719.pdf&id=5188&source=OATD&language=en ; http://www.cris.uns.ac.rs/record.jsf?recordId=100362&source=OATD&language=en
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
26.
長岡, 進矢.
Hepatic flares promote rapid decline of serum hepatitis B surface antigen (HBsAg) in patients with HBsAg seroclearance: A long-term follow-up study : B型肝炎長期観察例におけるHBsAg陰性化までのHBsAgの減衰と肝機能上昇との関連.
Degree: 博士(医学), 2016, Nagasaki University / 長崎大学
URL: http://hdl.handle.net/10069/36232
► Aim: Serum hepatitis B surface antigen (HBsAg) seroclearance is one of the ultimate goals of management of chronic hepatitis B. We investigated the kinetics of…
(more)
▼ Aim: Serum hepatitis B surface antigen (HBsAg) seroclearance is one of the ultimate goals of management of chronic hepatitis B. We investigated the kinetics of serum HBsAg before HBsAg seroclearance in patients with chronic hepatitis B. Methods: We retrospectively analyzed 392 Japanese chronic hepatitis B patients who had been followed for 5 years or more between 1980 and 2000. Serum HBsAg levels were measured annually using chemiluminescent enzyme immunoassay. Results: During a median follow up of 14 years, 50 patients demonstrated HBsAg seroclearance (annual incidence rate, 0.91%). Multivariate analysis with baseline characteristics revealed that HBsAg of less than 3.3 log IU/mL (hazard ratio [HR],
2.22; P = 0.008) and treatmentwith nucleoside/nucleotide analog (HR, 0.12; P = 0.001) were independent predictive factors for seroclearance. The median HBsAg levels at 20, 10, 5, 3 and 1 year prior to seroclearance were 3.89, 2.84, 1.84, 0.78 and −1.10 log IU/mL, respectively. The rapid decline group, comprising patients who achieved HBsAg seroclearance within 5 years after confirmed HBsAg levels of 2 log IU/mL, demonstrated: (i) high alanine aminotransferase (ALT) levels; and (ii) a low frequency of liver cirrhosis progression. A significant reduction
in annual HBsAg levels was found in years marked by at least one ALT flare (ALT ≥200 IU/L) (flare [+], n = 62) than in those without (flare [−], n = 323) (0.29 vs 0.17 log IU/mL/year, P=0.003). Conclusion: Hepatic flares promoted rapid declines and greater annual reductions of HBsAg levels in patients with HBsAg seroclearance.
Subjects/Keywords: alanine aminotransferase flare; chronic hepatitis B; hepatitis B surface antigen seroclearance; hepatitis B surface antigen quantification
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APA ·
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Export
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APA (6th Edition):
長岡, . (2016). Hepatic flares promote rapid decline of serum hepatitis B surface antigen (HBsAg) in patients with HBsAg seroclearance: A long-term follow-up study : B型肝炎長期観察例におけるHBsAg陰性化までのHBsAgの減衰と肝機能上昇との関連. (Thesis). Nagasaki University / 長崎大学. Retrieved from http://hdl.handle.net/10069/36232
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
長岡, 進矢. “Hepatic flares promote rapid decline of serum hepatitis B surface antigen (HBsAg) in patients with HBsAg seroclearance: A long-term follow-up study : B型肝炎長期観察例におけるHBsAg陰性化までのHBsAgの減衰と肝機能上昇との関連.” 2016. Thesis, Nagasaki University / 長崎大学. Accessed December 10, 2019.
http://hdl.handle.net/10069/36232.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
長岡, 進矢. “Hepatic flares promote rapid decline of serum hepatitis B surface antigen (HBsAg) in patients with HBsAg seroclearance: A long-term follow-up study : B型肝炎長期観察例におけるHBsAg陰性化までのHBsAgの減衰と肝機能上昇との関連.” 2016. Web. 10 Dec 2019.
Vancouver:
長岡 . Hepatic flares promote rapid decline of serum hepatitis B surface antigen (HBsAg) in patients with HBsAg seroclearance: A long-term follow-up study : B型肝炎長期観察例におけるHBsAg陰性化までのHBsAgの減衰と肝機能上昇との関連. [Internet] [Thesis]. Nagasaki University / 長崎大学; 2016. [cited 2019 Dec 10].
Available from: http://hdl.handle.net/10069/36232.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
長岡 . Hepatic flares promote rapid decline of serum hepatitis B surface antigen (HBsAg) in patients with HBsAg seroclearance: A long-term follow-up study : B型肝炎長期観察例におけるHBsAg陰性化までのHBsAgの減衰と肝機能上昇との関連. [Thesis]. Nagasaki University / 長崎大学; 2016. Available from: http://hdl.handle.net/10069/36232
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Dalhousie University
27.
Dawson, Paul WH.
Hepatitis B Virus X Protein Induces Cellular Senescence and
Autophagy.
Degree: MS, Department of Microbiology &
Immunology, 2011, Dalhousie University
URL: http://hdl.handle.net/10222/14156
► Hepatitis B virus (HBV) is a significant global threat to human health due to its ability to cause chronic infections that can lead to hepatocellular…
(more)
▼ Hepatitis B virus (HBV) is a significant global threat
to human health due to its ability to cause chronic infections that
can lead to hepatocellular carcinoma (HCC). While the process by
which HBV increases the risk of HCC is unclear, evidence suggests
that the
hepatitis B X protein (HBx) may be a contributing factor.
Cellular senescence is an important barrier to tumorigenesis,
blocking the proliferation of cells that harbor excessive DNA
damage or contain activated oncogenes. Autophagy is a
non-proteasomal degradative pathway used by cells to recycle
cytoplasmic contents under periods of nutrient starvation. This
pathway is induced in response to a wide range of cellular stress
factors, and has also been characterized as an effector mechanism
for the establishment of cellular senescence. In this study,
retroviral transduction of HepG2 cells with HBx resulted in the
induction of cellular senescence and autophagy. The mechanism by
which HBx can induce senescence is unclear. However, an increase in
the accumulation of DNA damage was observed. HBx did not modulate
the levels of the anti-apoptotic proteins Bcl-2, Bcl-xL, or Mcl-1,
which can inhibit autophagy through interactions with the autophagy
regulator Beclin 1. As well, the activity and phosphorylation
status of JNK/SAPK, an inducer of autophagy via Bcl-2
phosphorylation, was unchanged. These results suggest that
senescence may act as a barrier to HBx-induced oncogenesis, and may
offer some explanation as to why HBx does not function as a more
potent oncogene. Also, we propose that HBx modulates autophagy
through a mechanism other than Bcl-2 phosphorylation or expression
over the time course of this study.
Advisors/Committee Members: John Rohde (external-examiner), Rafael Garduno (graduate-coordinator), Craig McCormick (thesis-reader), Roy Duncan (thesis-reader), Chris Richardson (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: Hepatitis B; Autophagy; Cellular Senescence; HBx
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APA ·
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APA (6th Edition):
Dawson, P. W. (2011). Hepatitis B Virus X Protein Induces Cellular Senescence and
Autophagy. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/14156
Chicago Manual of Style (16th Edition):
Dawson, Paul WH. “Hepatitis B Virus X Protein Induces Cellular Senescence and
Autophagy.” 2011. Masters Thesis, Dalhousie University. Accessed December 10, 2019.
http://hdl.handle.net/10222/14156.
MLA Handbook (7th Edition):
Dawson, Paul WH. “Hepatitis B Virus X Protein Induces Cellular Senescence and
Autophagy.” 2011. Web. 10 Dec 2019.
Vancouver:
Dawson PW. Hepatitis B Virus X Protein Induces Cellular Senescence and
Autophagy. [Internet] [Masters thesis]. Dalhousie University; 2011. [cited 2019 Dec 10].
Available from: http://hdl.handle.net/10222/14156.
Council of Science Editors:
Dawson PW. Hepatitis B Virus X Protein Induces Cellular Senescence and
Autophagy. [Masters Thesis]. Dalhousie University; 2011. Available from: http://hdl.handle.net/10222/14156
University of Aberdeen
28.
Tachtatzis, Phaedra Maria.
Accelerated ageing, senescence and the natural history of chronic hepatitis B virus infection.
Degree: Thesis (M.D.), 2015, University of Aberdeen
URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=228557
;
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.680959
► Hepatitis B virus infection (HBV) is an important health problem worldwide, with a significant rate of chronic infection, which can lead to cirrhosis and hepatocellular…
(more)
▼ Hepatitis B virus infection (HBV) is an important health problem worldwide, with a significant rate of chronic infection, which can lead to cirrhosis and hepatocellular carcinoma (HCC). Increased age is an important determinant of progression to cirrhosis and HCC, possibly because age is a crude measure of the duration of HBV infection. Increasing age is associated with changes in liver structure, blood flow and function and with reduced response to injury, impaired regeneration and increased mortality in acute liver disease. Age has been identified as a co‐factor in several chronic liver diseases including chronic hepatitis C infection (HCV). Available evidence suggests differential ageing of various intrahepatic cell types in different liver diseases and the ageing process may be more complex in the liver than originally thought. Telomeres are DNA structures located at the end of each chromosome, which protect the underlying coding DNA from breaks and fusions and shorten with increasing age. Both DNA damage and cell proliferation lead to progressive telomere shortening, which ultimately leads to cell cycle arrest and a state of replicative senescence. Persistent HCV and HBV infections lead to cell cycle arrest, providing a favourable environment for viral replication. Evidence suggests that progressive telomere shortening occurs with advancing stage of liver disease in HBV and specifically from cirrhosis through large cell dysplasia to small cell dysplasia and to HCC. Whether cell cycle arrest leads to a senescent‐like state or whether this is the result of oxidative stress is unknown. Unpublished data using cell cycle phase markers in chronic HBV infection reveal that hepatocytes, which support HBV replication, are arrested in G1, which is mediated by hepatocyte p21 expression. I hypothesise that: 1. In normal liver tissue, different cell types age at different rates and this is altered during disease; 2. Hepatocyte senescence plays a significant role in the natural course of chronic HBV infection and underlies HBV antigen expression. I developed and optimised large volume Q‐FISH methodology to measure telomere length and nuclear size in a variety of intrahepatic cell lineages. In normal liver tissue, cholangiocytes had longer telomeres compared with all other intrahepatic lineages over a wide age range. Hepatocytes did not show any age‐related telomere shortening, in contrast to Kupffer and hepatic stellate cells. In chronic HBV infection, all hepatocytes had shortened telomeres when compared to age and sex‐matched controls consistent with accelerated ageing. HBV replication was confined to those hepatocytes with longer telomeres, suggesting that HBV entry or replication is less efficient in older hepatocytes and compatible with the fall in serum HBV DNA and HBsAg titre seen with advancing age. There may be two populations of hepatocytes in chronic HBV infection; hepatocytes that are growth arrested with short telomeres not supporting HBV replication and biologically 'younger' hepatocytes with longer telomeres…
Subjects/Keywords: 616.9; Hepatitis B virus; Liver cells; Fibrosis
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APA ·
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APA (6th Edition):
Tachtatzis, P. M. (2015). Accelerated ageing, senescence and the natural history of chronic hepatitis B virus infection. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=228557 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.680959
Chicago Manual of Style (16th Edition):
Tachtatzis, Phaedra Maria. “Accelerated ageing, senescence and the natural history of chronic hepatitis B virus infection.” 2015. Doctoral Dissertation, University of Aberdeen. Accessed December 10, 2019.
http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=228557 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.680959.
MLA Handbook (7th Edition):
Tachtatzis, Phaedra Maria. “Accelerated ageing, senescence and the natural history of chronic hepatitis B virus infection.” 2015. Web. 10 Dec 2019.
Vancouver:
Tachtatzis PM. Accelerated ageing, senescence and the natural history of chronic hepatitis B virus infection. [Internet] [Doctoral dissertation]. University of Aberdeen; 2015. [cited 2019 Dec 10].
Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=228557 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.680959.
Council of Science Editors:
Tachtatzis PM. Accelerated ageing, senescence and the natural history of chronic hepatitis B virus infection. [Doctoral Dissertation]. University of Aberdeen; 2015. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=228557 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.680959
Univerzitet u Beogradu
29.
Kanazir, Milena S., 1964-.
Ispitivanje prediktora vakcinalnog statusa povezanog sa
imunizacijom protiv hepatitisa B kod osoba zaposlenih u
zdravstvenim ustanovama.
Degree: Medicinski fakultet, 2016, Univerzitet u Beogradu
URL: https://fedorabg.bg.ac.rs/fedora/get/o:14069/bdef:Content/get
► Medicina - Epidemiologija / Medicine - Epidemiology
Uvod: Osobe zaposlene u zdravstvenim ustanovama predstavljaju kohortu visokog rizika za nastanak infekcije izazvane virusom hepatitisa B (HBV).…
(more)
▼ Medicina - Epidemiologija / Medicine -
Epidemiology
Uvod: Osobe zaposlene u zdravstvenim ustanovama
predstavljaju kohortu visokog rizika za nastanak infekcije izazvane
virusom hepatitisa B (HBV). Procenjuje se da se, na globalnom
nivou, svake godine 600.000-800.000 osoba zaposlenih u zdravstvenim
ustanovama poseče ili ubode iglom na radnom mestu. Takođe, prema
ovim procenama, oko 5,9% zdravstvenih radnika biva izloženo HBV što
rezulira sa oko 66.000 novoinficiranih. U zemljama u razvoju za
40-60% svih HBV infekcija u grupi zdravstvenih radnika odgovorna je
profesionalna ekspozicija. U razvijenim zemljama je nešto manje od
10% slučajeva hepatitisa B u grupi zdravstvenih radanika povezano
sa kontaktom sa krvlju i krvnim derivatima na radnom mestu, što se
dovodi u vezu sa značajno većim vakcinalnim obuhvatom. Iako je
bezbedna i efektivna vakcina dostupna od 1982. godine, veliki broj
zdravstvenih radnika na globalnom nivou se ne vakciniše protiv ove
bolesti. Istraživanja na nivou svetske populacije su pokazala da je
oko 90% zdravstvenih radnika svesno činjenice da je potrebno da se
vakcinišu, ali da samo nešto više od 50% to i uradi. Stoga, danas
se smatra da se u pozadini prijemčivosti vakcine protiv hepatitisa
B u grupi zdravstvenih radnika nalazi čitav niz psiholoških,
profesionalnih i bihejvioralnih faktora koji potencijalno utiču na
ovu komplesnu sliku. Ciljevi: (I) Procena prevalencije vakcinacije
protiv hepatitisa B u grupi osoba zaposlenih u ustanovama
tercijarnog nivoa zdravstvene zaštite u Beogradu; (II) Ispitivanje
znanja, stavova i ponašanja osoba zaposlenih u zdravstvenim
ustanovama u vezi sa vakcinacijom protiv hepatitisa B; (III)
Ispitivanje prediktora vakcinalnog statusa povezanog sa
imunizacijom protiv hepatitisa B kod osoba zaposlenih u
zdravstvenim ustanovama. Materijal i metod: Istraživanje je
dizajnirano po tipu studije preseka. Target grupu činili su svi
zaposleni u Kliničkom centru Srbije (KCS) u Beogradu, koji su
metodom slučajnog izbora, po principu formiranja višefaznog uzorka,
selektovani za uključivanje u studiju tokom decembra 2015. godine.
Uzorak je činio 7,1% svih zaposlenih u KCS. Osnovni instrument za
prikupljanje podataka bio je strukturirani upitnik, koji je
sastavljen na bazi literaturnih podataka. Prvi deo upitnika
obuhvatio je socijalno-demografske i profesionalne karakteristike
ispitanika: pol, uzrast, bračni status, obrazovanje, zanimanje, tip
radnog mesta i ukupan broj godina radnog staža. Drugi deo sadržao
je upitnik o znanju o hepatitisu B...
Advisors/Committee Members: Kisić-Tepavčević, Darija, 1975-.
Subjects/Keywords: hepatitis B; vaccination; health-care workers;
acceptance
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APA (6th Edition):
Kanazir, Milena S., 1. (2016). Ispitivanje prediktora vakcinalnog statusa povezanog sa
imunizacijom protiv hepatitisa B kod osoba zaposlenih u
zdravstvenim ustanovama. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:14069/bdef:Content/get
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kanazir, Milena S., 1964-. “Ispitivanje prediktora vakcinalnog statusa povezanog sa
imunizacijom protiv hepatitisa B kod osoba zaposlenih u
zdravstvenim ustanovama.” 2016. Thesis, Univerzitet u Beogradu. Accessed December 10, 2019.
https://fedorabg.bg.ac.rs/fedora/get/o:14069/bdef:Content/get.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kanazir, Milena S., 1964-. “Ispitivanje prediktora vakcinalnog statusa povezanog sa
imunizacijom protiv hepatitisa B kod osoba zaposlenih u
zdravstvenim ustanovama.” 2016. Web. 10 Dec 2019.
Vancouver:
Kanazir, Milena S. 1. Ispitivanje prediktora vakcinalnog statusa povezanog sa
imunizacijom protiv hepatitisa B kod osoba zaposlenih u
zdravstvenim ustanovama. [Internet] [Thesis]. Univerzitet u Beogradu; 2016. [cited 2019 Dec 10].
Available from: https://fedorabg.bg.ac.rs/fedora/get/o:14069/bdef:Content/get.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kanazir, Milena S. 1. Ispitivanje prediktora vakcinalnog statusa povezanog sa
imunizacijom protiv hepatitisa B kod osoba zaposlenih u
zdravstvenim ustanovama. [Thesis]. Univerzitet u Beogradu; 2016. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:14069/bdef:Content/get
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
30.
Aguilar Pianto, Eddy Anderson.
Relación entre el nivel de conocimientos y actitudes hacia la hepatitis B en estudiantes de pregrado de la Facultad de Odontología de la UNMSM, 2015.
Degree: 2016, National University of San Marcos
URL: http://cybertesis.unmsm.edu.pe/handle/cybertesis/4892
;
http://cybertesis.unmsm.edu.pe/bitstream/cybertesis%2F4892/2/bitstream
;
http://cybertesis.unmsm.edu.pe/bitstream/cybertesis%2F4892/1/bitstream
► Determina la relación entre el nivel de conocimiento y la actitud hacia la Hepatitis B que presentan los estudiantes de pre grado de la Facultad…
(more)
▼ Determina la relación entre el nivel de conocimiento y la actitud hacia la
Hepatitis B que presentan los estudiantes de pre grado de la Facultad de Odontología de la Universidad Nacional Mayor de San Marcos, en el año 2015. La hipótesis planteaba una relación directa entre el nivel de conocimiento y la actitud. El tipo de estudio es descriptivo transversal. La muestra está constituida por 135 estudiantes. Aplica una encuesta tipo cuestionario con 15 preguntas de alternativas múltiple para la variable conocimiento y un cuestionario tipo Lickert con 18 items para la variable actitud. Determina que el nivel de conocimiento es mayoritariamente regular (93.3%), los items relacionados a conocimientos sobre medidas preventivas para evitar una infección con
Hepatitis B son los que menos respuestas correctas tuvieron (38,1%). La pregunta con menos respuestas correctas se refiere al esquema de vacunación contra la
Hepatitis B (14 alumnos), el origen viral del
Hepatitis B es el ítem que obtuvo mayor número de respuestas correctas (133 alumnos). La mayoría muestra un nivel de actitud indiferente hacia la
Hepatitis B (93.3%). El 25% de los alumnos piensa que no deberían atender pacientes con
Hepatitis B, un 66% de los alumnos piensan que a pesar de tomar todas las medidas de bioseguridad sienten temor de atender pacientes con
Hepatitis B. Según los datos obtenidos se concluye que no existe relación entre el nivel de conocimiento y la actitud hacia la
Hepatitis B en los estudiantes de la Facultad de Odontología de la Universidad Nacional Mayor de San Marcos.
Advisors/Committee Members: Madrid Chumacero, Marco Tulio.
Subjects/Keywords: Hepatitis B; Estudiantes de odontología - Actitudes
Record Details
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Record Details
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« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Aguilar Pianto, E. A. (2016). Relación entre el nivel de conocimientos y actitudes hacia la hepatitis B en estudiantes de pregrado de la Facultad de Odontología de la UNMSM, 2015. (Thesis). National University of San Marcos. Retrieved from http://cybertesis.unmsm.edu.pe/handle/cybertesis/4892 ; http://cybertesis.unmsm.edu.pe/bitstream/cybertesis%2F4892/2/bitstream ; http://cybertesis.unmsm.edu.pe/bitstream/cybertesis%2F4892/1/bitstream
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Aguilar Pianto, Eddy Anderson. “Relación entre el nivel de conocimientos y actitudes hacia la hepatitis B en estudiantes de pregrado de la Facultad de Odontología de la UNMSM, 2015.” 2016. Thesis, National University of San Marcos. Accessed December 10, 2019.
http://cybertesis.unmsm.edu.pe/handle/cybertesis/4892 ; http://cybertesis.unmsm.edu.pe/bitstream/cybertesis%2F4892/2/bitstream ; http://cybertesis.unmsm.edu.pe/bitstream/cybertesis%2F4892/1/bitstream.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Aguilar Pianto, Eddy Anderson. “Relación entre el nivel de conocimientos y actitudes hacia la hepatitis B en estudiantes de pregrado de la Facultad de Odontología de la UNMSM, 2015.” 2016. Web. 10 Dec 2019.
Vancouver:
Aguilar Pianto EA. Relación entre el nivel de conocimientos y actitudes hacia la hepatitis B en estudiantes de pregrado de la Facultad de Odontología de la UNMSM, 2015. [Internet] [Thesis]. National University of San Marcos; 2016. [cited 2019 Dec 10].
Available from: http://cybertesis.unmsm.edu.pe/handle/cybertesis/4892 ; http://cybertesis.unmsm.edu.pe/bitstream/cybertesis%2F4892/2/bitstream ; http://cybertesis.unmsm.edu.pe/bitstream/cybertesis%2F4892/1/bitstream.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Aguilar Pianto EA. Relación entre el nivel de conocimientos y actitudes hacia la hepatitis B en estudiantes de pregrado de la Facultad de Odontología de la UNMSM, 2015. [Thesis]. National University of San Marcos; 2016. Available from: http://cybertesis.unmsm.edu.pe/handle/cybertesis/4892 ; http://cybertesis.unmsm.edu.pe/bitstream/cybertesis%2F4892/2/bitstream ; http://cybertesis.unmsm.edu.pe/bitstream/cybertesis%2F4892/1/bitstream
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
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Open Access Theses and Dissertations