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Universidade de Brasília

1. Mariana Laundry de Mesquita. Potencial antitumoral de substâncias isoladas de plantas do Cerrado brasileiro: estudos preliminares do mecanismo de ação da atividade citotóxica.

Degree: 2009, Universidade de Brasília

Cancer is an ailment that affects more or less 200 different types of cells. Its major characteristic is the lack of proliferation control, differentiation and apoptosis, with an uncontrolled multiplication of cells, with the ability of invading organs and tissues. There are many difficulties in the cancer treatment, with the most frequent being the drug resistance, toxicity and low specificity. As most of the molecules are water insoluble, the administration of the drug in the blood stream may cause edema and necrosis. The substances obtained from the Brazilian Cerrado plants are interesting models for the development of new anticancer molecules. The present study investigated the cytotoxic potential of 412 Cerrado plant extracts against three human cancer cell lines: MDA-MB-435 (melanoma), HCT-8 (colon) and SF-295 (glioblastome). Of the tested extracts, 28 demonstrated a substantial antiproliferative effect, inhibiting significantly the tumor cell proliferation at 50 μg/ml. Complete dose-response curves were generated and IC50 values (concentration causing 50% inhibition of parasite growth) were calculated for these extracts against four cell lines MDA-MB-435, HCT-8, SF-295 and HL-60 (Promielocitic Leukemia). The extracts that showed IC50 values <20 g/ml, in at least three cell lines were considered very actives. Among them, the hexane extracts of Kielmeyera coriacea and Simarouba versicolor root bark, and the dichloromethane extract of Schinus terebinthifolius var. raddianus leaves. These extracts were submitted to a bioassay-guided fractionation and anticancer substances were isolated. From the hexane extract of Simarouba versicolor root bark we isolated the glaucarubinone, a substance with remarked anticancer activity. The bioassay-guided fractionation of the dichloromethane extract of Schinus terebinthifolius var. raddianus leaves resulted in the isolation of five compounds, including an alkyl resorcinol obtained for the first time from this species, and beta-sytosterol. From the hexane extract of Kielmeyera coriacea root bark were obtained a mixture of the vitamin E derivative, δ-tocotrienol and its peroxydimer. This mixture showed antiproliferative and cytotoxic effects against the cells, through DNA synthesis inhibition and induction of cell death by apoptosis and necrosis. It is a promising sample to have its structure-activity relationship investigated.

O Câncer é uma doença, que atinge mais ou menos 200 tipos de células, caracterizada pelo desvio no controle da proliferação, diferenciação e morte celular, com multiplicação desordenada das células, podendo invadir órgãos e tecidos. As dificuldades encontradas no seu tratamento são a resistência medicamentosa, toxicidade, baixa especificidade, além da maioria das formulações serem injetáveis, pois são moléculas insolúveis em água, causando edemas e necrose. As substâncias de plantas do Cerrado podem constituir modelos interessantes para o desenvolvimento de novas moléculas anticancerígenas. Neste estudo foi realizada uma triagem com…

Advisors/Committee Members: José Carlos Tavares Carvalho, Eloisa Dutra Caldas, Laila Salmen Espindola Darvenne, Celio Lopes Silva, Raphael Grougnet.

Subjects/Keywords: Kielmeyera coriacea; Simarouba versicolor; Schinus terebinthifolius var. radiannus; glaucarubinona; MEDICINA; Cerrado; Kielmeyera coriacea; Simarouba versicolor; Schinus terebinthifolius var. radiannus; glaucarubinone; cancer cells; delta-tocotrienol; Cerrado; células cancerígenas

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APA (6th Edition):

Mesquita, M. L. d. (2009). Potencial antitumoral de substâncias isoladas de plantas do Cerrado brasileiro: estudos preliminares do mecanismo de ação da atividade citotóxica. (Thesis). Universidade de Brasília. Retrieved from http://bdtd.bce.unb.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=5035

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Mesquita, Mariana Laundry de. “Potencial antitumoral de substâncias isoladas de plantas do Cerrado brasileiro: estudos preliminares do mecanismo de ação da atividade citotóxica.” 2009. Thesis, Universidade de Brasília. Accessed September 20, 2020. http://bdtd.bce.unb.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=5035.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Mesquita, Mariana Laundry de. “Potencial antitumoral de substâncias isoladas de plantas do Cerrado brasileiro: estudos preliminares do mecanismo de ação da atividade citotóxica.” 2009. Web. 20 Sep 2020.

Vancouver:

Mesquita MLd. Potencial antitumoral de substâncias isoladas de plantas do Cerrado brasileiro: estudos preliminares do mecanismo de ação da atividade citotóxica. [Internet] [Thesis]. Universidade de Brasília; 2009. [cited 2020 Sep 20]. Available from: http://bdtd.bce.unb.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=5035.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mesquita MLd. Potencial antitumoral de substâncias isoladas de plantas do Cerrado brasileiro: estudos preliminares do mecanismo de ação da atividade citotóxica. [Thesis]. Universidade de Brasília; 2009. Available from: http://bdtd.bce.unb.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=5035

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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