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1. Stam, P. The effect of initial linkage disequilibrium and natural selection in pooled populations : experiments with Tribolium and simulation.

Degree: 1972, Landbouwhogeschool Wageningen

<p/>In chapter 2 a number of the mechanisms are discussed through which genetic polymorphisms can be maintained in natural populations: overdominance, frequency dependent selection and neutral alleles with associative overdominance. The overdominance model is emphasized because overdominance is also the basic feature of the associative overdominance model. Different theoretical relationships between number of heterozygous loci and fitness are explored, including their implications with regard to mean population fitness and selection coefficients at individual loci in an ideal population. From these, King's threshold model for multiple gene action on fitness proved to be the most satisfactory in all respects: it accomodates fairly high selection coefficients at individual loci without implying too heavy a load; it further explains different inbreeding depressions for different organisms and for different environments, as well as genotype by environment interaction. The model of associative overdominance, with the incorporation of King's threshold model for multiple gene action, has been chosen as an operational hypothesis for explanation of my experimental results (chapter 3) and as a basis for the simulation study (chapter 4).<p/>Chapter 2 further discusses the implications of associative overdominance (which is a result of overall linkage disequilibrium in finite populations) when linkage disequilibrium is generated artificially by using a small sample to found a new population. In this situation pseudo-frequency dependent selection is expected to occur at selectively neutral loci. An experimental design is proposed which distinguishes between apparent and real frequency dependent selection.<p/>Chapter 3 presents the experiments: individuals from two laboratory stocks of Tribolium castaneum HERBST, together with their F 1 , were used to initiate a set of polymorphic populations (for the black locus) with different frequencies of the marker allele. These experiments, jointly taken, indicate that the black locus itself is selectively neutral under the current experimental conditions and rule out the possibility of real frequency dependent selection. There was however apparent selection against the mutant allele due to initial linkage disequilibrium. This linkage disequilibrium is described in terms of the different genotypic backgrounds of the components (wild type and mutant stock and F 1 ) of the founder population: in the mutant stock there is an excess of homozygosity which may be randomly distributed over the chromosomes or may be partially or wholly concentrated in a chromosome region near the marker locus. This confirms the expectation formulated in the Introduction (chapter 1). The initial linkage disequilibrium, in these experiments is not so much due to small samples from the founder stocks as to the different genotypic backgrounds of the founder stocks, and, with respect to neutral loci, implies associative dominance rather than… Advisors/Committee Members: J.H. van der Veen.

Subjects/Keywords: biometrie; dominantie; genen; genetica; heritability; overerving; koppeling; recessieve genen; recessiviteit; geslachtskoppeling; tenebrionidae; statistische analyse; kernerfelijkheid; Genetica (algemeen); biometry; dominance; genes; genetics; heritability; inheritance; linkage; recessive genes; recessiveness; sex linkage; tenebrionidae; statistical analysis; nuclear inheritance; Genetics (General)

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APA (6th Edition):

Stam, P. (1972). The effect of initial linkage disequilibrium and natural selection in pooled populations : experiments with Tribolium and simulation. (Doctoral Dissertation). Landbouwhogeschool Wageningen. Retrieved from http://library.wur.nl/WebQuery/wurpubs/421747 ; urn:nbn:nl:ui:32-421747 ; urn:nbn:nl:ui:32-421747 ; http://library.wur.nl/WebQuery/wurpubs/421747

Chicago Manual of Style (16th Edition):

Stam, P. “The effect of initial linkage disequilibrium and natural selection in pooled populations : experiments with Tribolium and simulation.” 1972. Doctoral Dissertation, Landbouwhogeschool Wageningen. Accessed May 09, 2021. http://library.wur.nl/WebQuery/wurpubs/421747 ; urn:nbn:nl:ui:32-421747 ; urn:nbn:nl:ui:32-421747 ; http://library.wur.nl/WebQuery/wurpubs/421747.

MLA Handbook (7th Edition):

Stam, P. “The effect of initial linkage disequilibrium and natural selection in pooled populations : experiments with Tribolium and simulation.” 1972. Web. 09 May 2021.

Vancouver:

Stam P. The effect of initial linkage disequilibrium and natural selection in pooled populations : experiments with Tribolium and simulation. [Internet] [Doctoral dissertation]. Landbouwhogeschool Wageningen; 1972. [cited 2021 May 09]. Available from: http://library.wur.nl/WebQuery/wurpubs/421747 ; urn:nbn:nl:ui:32-421747 ; urn:nbn:nl:ui:32-421747 ; http://library.wur.nl/WebQuery/wurpubs/421747.

Council of Science Editors:

Stam P. The effect of initial linkage disequilibrium and natural selection in pooled populations : experiments with Tribolium and simulation. [Doctoral Dissertation]. Landbouwhogeschool Wageningen; 1972. Available from: http://library.wur.nl/WebQuery/wurpubs/421747 ; urn:nbn:nl:ui:32-421747 ; urn:nbn:nl:ui:32-421747 ; http://library.wur.nl/WebQuery/wurpubs/421747

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