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1. Kolundžić Nikola. Galectin-1 and functional properties of human trophoblast cells in vitro.

Degree: PhD, Biology, 2012, University of Belgrade

Galectin-1 (gal-1) is expressed at the fetomaternal interface in a manner suggestive of a potential involvement in cell adhesion, migration and invasion of the human trophoblast. These processes are considered essential for the embryo implantation and formation of the functional placenta. However, no studies have examined the role of the gal-1 in the human placenta. Hypothesis that gal-1 may be relevant for trophoblast invasion was addressed by this thesis for the first time. To this end appropriate functional tests of cell adhesion, migration and invasion were performed in vitro, using invasive trophoblast models (isolated first trimester cytotrophoblast, immortalized extravillous HTR-8/SVneo cell line and choriocarcinoma JAr cell line). Since gal-1 is synthesised by both extravillous cytotrophoblast and decidual stromal cells in vivo, selected approaches addressed possible effect of both endogenous and exogenous gal-1. Use of function blocking anti-gal-1 antibody provided an insight into participation of endogenous gal-1, while supplementation by either molecular form of biologically active recombinant human gal-1, CS-gal-1 (with lectin activity) or Ox-gal-1 (without lectin activity) indicated relevance of exogenous gal-1 for trophoblast invasion in vitro. The importance of lectin-type interactions was investigated primarily using lactose (an inhibitory sugar for galectins). Since the expression patterns and functions of galectins often overlap, galectin profile of the invasive trophoblast at RNA and protein levels was established here. This is the first study to address the functional relevance of any galectin for human trophoblast invasivness in vitro, qualifying gal-1 as an important member of the trophoblast cell invasion machinery. It is documented here that endogenous gal-1, as well as additional exogenous gal-1 (both forms, but particularly the form with lectin activity) participate in trophoblast invasion, suggesting possible involvement of trophoblastic and decidual gal-1 in this process in vivo. Galectin profile of the invasive trophoblast was established here for the first time, which comprised of gal-1, gal-3 and gal-8. The obtained findings improve current understanding of the biological relevance of the gal-1 for the trophoblast function in vitro. These results provide the basis for further investigation of the mechanisms and effector molecules involved in gal-1 induced processes. Potential relevance of other expressed members of the galectin family for the invasive trophoblast remains to be elucidated.

U zoni interakcije majke i fetusa galektin-1 (gal-1) je eksprimiran na način koji ukazuje na njegovu moguću ulogu u ćelijskoj adheziji, migraciji i invaziji trofoblasta, procesima koji su ključni za implantaciju embriona i formiranje funkcionalne placente. Međutim, uloga gal-1 u trofoblastu čoveka dosada nije bila ispitivana, što je predmet istraživanja ovog doktorskog rada. U tu svrhu korišćeni su odgovarajući funkcionalni in vitro testovi adhezije,…

Subjects/Keywords: gal-1; trophoblast; cell invasion; isolated cytotrophoblast; HTR-8/SVneo; JAr; galectin profile; gal-8; gal-1; trofoblast; ćelijska invazija; izolovani citotrofoblast; HTR-8/SVneo; JAr; galektinski profil; gal-8

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Nikola, K. (2012). Galectin-1 and functional properties of human trophoblast cells in vitro. (Doctoral Dissertation). University of Belgrade. Retrieved from http://dx.doi.org/10.2298/BG20121226KOLUNDZIC ; http://eteze.bg.ac.rs/application/showtheses?thesesId=154 ; https://fedorabg.bg.ac.rs/fedora/get/o:5390/bdef:Content/get ; http://vbs.rs/scripts/cobiss?command=SEARCH&base=99999&select=ID=1024554930

Chicago Manual of Style (16th Edition):

Nikola, Kolundžić. “Galectin-1 and functional properties of human trophoblast cells in vitro.” 2012. Doctoral Dissertation, University of Belgrade. Accessed September 22, 2019. http://dx.doi.org/10.2298/BG20121226KOLUNDZIC ; http://eteze.bg.ac.rs/application/showtheses?thesesId=154 ; https://fedorabg.bg.ac.rs/fedora/get/o:5390/bdef:Content/get ; http://vbs.rs/scripts/cobiss?command=SEARCH&base=99999&select=ID=1024554930.

MLA Handbook (7th Edition):

Nikola, Kolundžić. “Galectin-1 and functional properties of human trophoblast cells in vitro.” 2012. Web. 22 Sep 2019.

Vancouver:

Nikola K. Galectin-1 and functional properties of human trophoblast cells in vitro. [Internet] [Doctoral dissertation]. University of Belgrade; 2012. [cited 2019 Sep 22]. Available from: http://dx.doi.org/10.2298/BG20121226KOLUNDZIC ; http://eteze.bg.ac.rs/application/showtheses?thesesId=154 ; https://fedorabg.bg.ac.rs/fedora/get/o:5390/bdef:Content/get ; http://vbs.rs/scripts/cobiss?command=SEARCH&base=99999&select=ID=1024554930.

Council of Science Editors:

Nikola K. Galectin-1 and functional properties of human trophoblast cells in vitro. [Doctoral Dissertation]. University of Belgrade; 2012. Available from: http://dx.doi.org/10.2298/BG20121226KOLUNDZIC ; http://eteze.bg.ac.rs/application/showtheses?thesesId=154 ; https://fedorabg.bg.ac.rs/fedora/get/o:5390/bdef:Content/get ; http://vbs.rs/scripts/cobiss?command=SEARCH&base=99999&select=ID=1024554930


Univerzitet u Beogradu

2. Kolundžić, Nikola M., 1983-. Galektin-1 i funkcionalna svojstva ćelija trofoblasta čoveka in vitro.

Degree: Biološki fakultet, 2013, Univerzitet u Beogradu

Biologija - Biogija reprodukcije / Biology - Biology of reproduction

U zoni interakcije majke i fetusa galektin-1 (gal-1) je eksprimiran na način koji ukazuje na njegovu moguću ulogu u ćelijskoj adheziji, migraciji i invaziji trofoblasta, procesima koji su ključni za implantaciju embriona i formiranje funkcionalne placente. Međutim, uloga gal-1 u trofoblastu čoveka dosada nije bila ispitivana, što je predmet istraživanja ovog doktorskog rada. U tu svrhu korišćeni su odgovarajući funkcionalni in vitro testovi adhezije, migracije i invazije na modelima invazivnog trofoblasta (izolovanom citotrofoblastu iz placenti prvog trimestra normalne trudnoće, imortalizovanoj ekstravilusnoj ćelijskoj linija HTR-8/SVneo, i, u manjoj meri, na horiokarcinomskoj ćelijskoj liniji JAr). Obzirom da gal-1 sintetišu i ekstravilusne trofoblastne i decidualne stromalne ćelije in vivo, u ovom radu je ispitivan mogući uticaj kako endogenog (upotrebom antitela prema gal-1 koja blokiraju i funkciju gal-1), tako i egzogenog gal-1 (upotrebom dveju molekulskih formi rekombinantnog humanog gal-1 dokazane biološke aktivnosti, od kojih jedna poseduje lektinsku aktivnost - CS-gal-1, a druga ne - Ox-gal-1) na funkcionalna svojstva trofoblasta in vitro. Značaj lektinskih interakcija za funkciju trofoblastnih ćelija ispitivan je funkcionalnim testovima u prisustvu laktoze (inhibitornog šećera za lektinski tip interakcija galektina). Zbog činjenice da se obrasci ekspresije, kao i funkcije galektina često znatno preklapaju, utvrđen je galektinskog profila invazivnog trofoblasta na nivou RNK i proteina. U ovom radu je po prvi put pokazan funkcionalni značaj nekog od galektina za invazivnost trofoblasta čoveka in vitro, kvalifikujući gal-1 za važnog člana grupe molekula koji učestvuju u trofoblastnoj invaziji. Pokazali smo da endogeni gal-1, kao i dodatni egzogeni gal-1 (obe ispitivane molekulske forme) stimulišu invaziju trofoblasta, što ukazuje na mogućnost da bi i u uslovima in vivo, gal-1, kako trofoblastnog, tako i decidualnog porekla, mogao biti uključen u ovaj proces. Dobijeni rezultati su pokazali i da se ovaj uticaj gal-1 na invazivnu sposobnost trofoblasta ostvaruje pre svega njegovom lektinskom aktivnošću. Ovim radom je po prvi put utvrđen galektinski profil invazivnog trofoblasta koji čine gal-1, gal-3, i do sada u trofoblastu čoveka neidentifikovani član galektinske familije, gal-8.

Advisors/Committee Members: Vićovac-Panić, Ljiljana.

Subjects/Keywords: gal-1; trophoblast; cell invasion; isolated cytotrophoblast; HTR-8/SVneo; JAr; galectin profile; gal-8

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Kolundžić, Nikola M., 1. (2013). Galektin-1 i funkcionalna svojstva ćelija trofoblasta čoveka in vitro. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:5390/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Kolundžić, Nikola M., 1983-. “Galektin-1 i funkcionalna svojstva ćelija trofoblasta čoveka in vitro.” 2013. Thesis, Univerzitet u Beogradu. Accessed September 22, 2019. https://fedorabg.bg.ac.rs/fedora/get/o:5390/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Kolundžić, Nikola M., 1983-. “Galektin-1 i funkcionalna svojstva ćelija trofoblasta čoveka in vitro.” 2013. Web. 22 Sep 2019.

Vancouver:

Kolundžić, Nikola M. 1. Galektin-1 i funkcionalna svojstva ćelija trofoblasta čoveka in vitro. [Internet] [Thesis]. Univerzitet u Beogradu; 2013. [cited 2019 Sep 22]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:5390/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kolundžić, Nikola M. 1. Galektin-1 i funkcionalna svojstva ćelija trofoblasta čoveka in vitro. [Thesis]. Univerzitet u Beogradu; 2013. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:5390/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Westerlund, Björn. Att svära eder i Nya testamentet : -hur Jesus, Petrus och Paulus förhåller sig till edssvärande.

Degree: philosophical and religious studies, 2019, Umeå University

Subjects/Keywords: Nya testamentet; Jesus; Petrus; Paulus; Ed; Eder; Svära; Horkos; Omnyo; Omnymi; Gud är mitt vittne; Bergspredikan; Matt 5:33-37; Matt 26:74; Mark 14:71; Rom 1:9; 2 Kor 1:18; 23; Gal 1:20; Fil 1:8; 1 Tess 2:5; 2:10; 1 Tess 5:27; lagen; evangelium; Matteus; autentiska brev; antiteser; triadstruktur; Stassen; DesRosiers; Religious Studies; Religionsvetenskap

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Westerlund, B. (2019). Att svära eder i Nya testamentet : -hur Jesus, Petrus och Paulus förhåller sig till edssvärande. (Thesis). Umeå University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-162067

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Westerlund, Björn. “Att svära eder i Nya testamentet : -hur Jesus, Petrus och Paulus förhåller sig till edssvärande.” 2019. Thesis, Umeå University. Accessed September 22, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-162067.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Westerlund, Björn. “Att svära eder i Nya testamentet : -hur Jesus, Petrus och Paulus förhåller sig till edssvärande.” 2019. Web. 22 Sep 2019.

Vancouver:

Westerlund B. Att svära eder i Nya testamentet : -hur Jesus, Petrus och Paulus förhåller sig till edssvärande. [Internet] [Thesis]. Umeå University; 2019. [cited 2019 Sep 22]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-162067.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Westerlund B. Att svära eder i Nya testamentet : -hur Jesus, Petrus och Paulus förhåller sig till edssvärande. [Thesis]. Umeå University; 2019. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-162067

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.